KR20100004977A - 세포사멸을 유도하는 이미다졸 유도체와 그것의 치료적 용도 - Google Patents
세포사멸을 유도하는 이미다졸 유도체와 그것의 치료적 용도 Download PDFInfo
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- KR20100004977A KR20100004977A KR1020097017486A KR20097017486A KR20100004977A KR 20100004977 A KR20100004977 A KR 20100004977A KR 1020097017486 A KR1020097017486 A KR 1020097017486A KR 20097017486 A KR20097017486 A KR 20097017486A KR 20100004977 A KR20100004977 A KR 20100004977A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P35/00—Antineoplastic agents
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
- C07D233/12—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D233/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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Abstract
Description
Claims (17)
- 세포사멸을 유도하기 위한 활성 성분으로써 하기 구조를 갖는 일반식(I)의 화합물을 포함하는 약학적 조성물:일반식 (I)(여기서, R1은 수소, C0-4 알킬아릴, C1-6 알킬, C3-8 시클로알킬 또는 -[(CH2)2-O]0-3-(CH2)2-NH2를 포함하지만, 이들에 한정되는 것은 아니며;R2는 알킬, C3-8 시클로알킬, C0-4 알킬아릴 또는 알케닐아릴을 포함하지만, 이들에 한정되는 것은 아니며;R3는 알킬, C3-8 시클로알킬, C0-4 알킬아릴 또는 알케닐아릴을 포함하지만, 이들에 한정되는 것은 아니며;R4는 알킬, C3-8 시클로알킬, C0-4 알킬아릴 또는 알케닐아릴을 포함하지만, 이들에 한정되는 것은 아니다.)
- 제3항 내지 제8항 중 어느 하나 기재의 화합물을 암 치료용 활성 성분으로 포함하는 약학적 조성물
- 제3항 내지 제8항 중 어느 하나 기재의 화합물로 암세포를 처리하여 암세포 사멸에 이르게 하는 세포사멸 유도 방법.
- 제 10항에 있어서,암세포의 사멸을 검출하는 단계를 더 포함하는 세포사멸 유도 방법.
- 제 11항에 있어서,암세포의 사멸 검출은 상기 암세포의 원형질막 상에서 인지질의 비대칭의 소멸을 측정하는 것으로 된 세포사멸 유도 방법.
- 제3항 내지 제8항 중 어느 하나 기재의 화합물을 자가면역질환 억제용 활성 성분으로 포함하는 약학적 조성물.
- 제3항 내지 제8항 중 어느 하나 기재의 화합물로 림프구를 처리하여 림프구를 비활성화시키는 인간 림프구 비활성화 방법.
- 제3항 내지 제8항 중 어느 하나 기재의 화합물을 낭포성 섬유증 치료용 활성 성분으로 포함하는 약학적 조성물.
- 제3항 내지 제8항 중 어느 하나 기재의 화합물로 돌연변이 낭포성 섬유증 트랜스멤브레인 전도성 조절 단백질(cystic fibrosis transmembrane conductance regulator, CFTR)을 발현하는 세포를 처리하여 돌연변이 단백질을 세포막에 위치하도록 하는 낭포성 섬유증의 치료 방법.
- 세포를 제3항 내지 제8항 중 어느 하나 기재의 화합물과 함께 배양하고, 검출하여 세포사멸을 유도하기 위한 추가적인 유용한 화합물을 동정하는 스크리닝 방법.
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PCT/KR2007/000970 WO2008105565A1 (en) | 2007-02-26 | 2007-02-26 | Imidazole derivatives that induce apoptosis and their therapeutic uses |
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US (1) | US8163791B2 (ko) |
JP (1) | JP5128615B2 (ko) |
KR (1) | KR101090850B1 (ko) |
DE (1) | DE112007003375B4 (ko) |
GB (1) | GB2462715B (ko) |
WO (1) | WO2008105565A1 (ko) |
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US8252789B2 (en) | 2007-11-29 | 2012-08-28 | Neuraltus Pharmaceuticals, Inc. | Compositions and methods for treating lysosomal disorders |
JP5855003B2 (ja) * | 2010-09-01 | 2016-02-09 | 国立大学法人京都大学 | 血液凝固調節物質のスクリーニング方法 |
CN103254134B (zh) * | 2012-06-29 | 2015-09-02 | 苏州大学 | 一种多取代咪唑的合成方法 |
KR101761660B1 (ko) * | 2013-09-27 | 2017-07-26 | 연세대학교 산학협력단 | 신규한 이미다졸 유도체 및 이의 치료학적 용도 |
CN103992276B (zh) * | 2014-06-03 | 2016-08-24 | 吉林省药物研究院 | 4’-{[(2,4,5-三取代苯基)-1h-咪唑-1-基]甲基}联苯-2-甲酸衍生物 |
WO2017179018A1 (en) * | 2016-04-15 | 2017-10-19 | University Of Ottawa | Tg2 inhibitor compounds and uses thereof |
WO2021143806A1 (zh) * | 2020-01-17 | 2021-07-22 | 中国人民解放军军事科学院军事医学研究院 | Hsp70抑制剂广谱抗黄病毒活性的应用 |
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US5700826A (en) * | 1995-06-07 | 1997-12-23 | Ontogen Corporation | 1,2,4,5-tetra substituted imidazoles as modulators of multi-drug resistance |
EP0812829A1 (en) * | 1996-06-14 | 1997-12-17 | Ontogen Corporation | Substituted imidazoles as modulators of multi-drug resistance |
JPH107660A (ja) * | 1996-06-18 | 1998-01-13 | Ontogen Corp | 多剤耐性の調節剤である置換イミダゾール類 |
DK1692113T3 (en) * | 2003-11-14 | 2018-01-08 | Lorus Therapeutics Inc | ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES |
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- 2007-02-26 WO PCT/KR2007/000970 patent/WO2008105565A1/en active Application Filing
- 2007-02-26 US US12/528,680 patent/US8163791B2/en not_active Expired - Fee Related
- 2007-02-26 GB GB0914199A patent/GB2462715B/en not_active Expired - Fee Related
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US20100105726A1 (en) | 2010-04-29 |
WO2008105565A1 (en) | 2008-09-04 |
GB2462715B (en) | 2011-08-03 |
GB2462715A (en) | 2010-02-24 |
JP2010521421A (ja) | 2010-06-24 |
DE112007003375T5 (de) | 2009-12-24 |
DE112007003375B4 (de) | 2013-11-07 |
GB0914199D0 (en) | 2009-09-16 |
JP5128615B2 (ja) | 2013-01-23 |
US8163791B2 (en) | 2012-04-24 |
GB2462715A8 (en) | 2010-03-24 |
KR101090850B1 (ko) | 2011-12-08 |
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