KR20090092461A - Antioxidant cosmetic composition - Google Patents

Abstract

A cosmetic composition having antioxidative effect is provided to have ability of removing free radical and activation effect of superoxide dismutation without skin irritation, allergy, and cytotoxicity. A cosmetic composition having antioxidative effect comprises 0.05~40 weight% of extracts of Herba Sauaaureae Involucratae, Cyperi Rhizoma, Anemarrhenae Rhizoma and Persicae Semen as active ingredients. The weight ratio of Herba Sauaaureae Involucratae, Cyperi Rhizoma, Anemarrhenae Rhizoma and Persicae Semen is 1:0.1-10:0.1-10:0.1-10. The cosmetic composition is used in the form of lotion, nutrition cream, massage cream, essence, pack, gel, ointment, patch or spray.

Description

Cosmetic composition having antioxidant effect {ANTIOXIDANT COSMETIC COMPOSITION}

The present invention relates to a cosmetic composition having an antioxidant effect, and more particularly, free radical scavenging activity and superoxide dismutation (SOD) activity effect is excellent, at the same time there is no specific odor, cytotoxicity, allergy compared with conventional antioxidants There is little irritation to the skin, and relates to a cosmetic composition having an excellent antioxidant stability when formulated in a cosmetic.

Generally, there are many theories explaining skin aging, but among them, the free radical theory that the skin ages due to free radicals caused by various factors in and out of the body is accepted as the most valid theory.

Free radicals are chemically highly reactive chemicals that occur when the skin is irradiated with UV light or during the respiration of cells in the skin. Most of the free radicals associated with aging of the skin are reactive oxygen species (ROS), which include superoxide radicals, hydrogen peroxide (H ₂ O ₂ ) and hydroxy radicals. And single oxygen.

These reactive oxygen species are generated during UV irradiation or respiratory process to cause peroxidation of lipids, which are components of cell membranes, through a multi-step chain reaction. Lipid peroxidation generates various active species such as radicals, peroxides, aldehydes and epoxides and damages DNA, RNA, proteins, cell membranes and cellular structures. Toxicity of these reactive oxygen species is considered to be a major cause of cancer, tissue damage, and aging (Black HS, Photochem photobiol, 46 (2), 213, 1987).

Peroxidation of the membrane lipids that make up the cell changes in cell membrane structure and fluidity, increases cellular permeability, leaks of lysosome enzymes, inactivation of membrane and transport proteins, and covalent crosslinking of lipids and proteins. ), Protein chain cleavage, DNA damage, and mutations, which are known to be most closely associated with skin aging and peroxidation of skin cell membranes.

Aerobic organisms have protective mechanisms to prevent the formation of these oxidants and lipid peroxidation, which include enzymes such as superoxide dismutase (SOD) and catalase and α-tocopherol (α- fat-soluble and water-soluble antioxidants or radical scavengers such as tocopherol, Vitamin E), β-carotene, ascorbic acid (vitamin C), glutathione and the like.

Since free radicals or reactive oxygen species are deeply related to skin aging as mentioned above, conventionally, superoxide dismuase (SOD), vitamin-E derivatives, vitamin C and derivatives thereof, flavonoids, and the like are incorporated into cosmetics in cosmetics. There have been many efforts to obtain the anti-aging effect. However, the conventional methods are difficult to stabilize or poor solubility, which makes it difficult to achieve a substantial effect due to the limitation of concentration in the actual product application. Thus, antioxidants known to date have most problems in terms of skin safety and stability in cosmetic formulation. It has a situation that its use is limited.

In order to solve the problems of the prior art as described above, an object of the present invention is to provide a cosmetic composition having an antioxidant effect excellent in free radical scavenging activity and superoxide dismutation (SOD) activity.

Another object of the present invention is to provide a cosmetic composition which has no specific odor, has little cytotoxicity, allergy, and irritation to the skin as compared with conventional antioxidants, and has an excellent antioxidant effect when formulated in cosmetics.

Another object of the present invention is to provide a cosmetic composition having an excellent antioxidant effect by adding to various types of cosmetic composition.

In order to achieve the above object, the present invention provides a cosmetic composition having an antioxidant effect, characterized in that, in the cosmetic composition having an antioxidant effect, including sulphurization, fragrant, Gimo, and Doin extract as an active ingredient.

The cosmetic composition according to the present invention not only has excellent free radical scavenging activity and superoxide dismutation (SOD) activity effect, but at the same time has no specific odor, and has little cytotoxicity, allergy, and irritation to skin as compared to conventional antioxidants. When formulated into cosmetics, the stability is excellent.

Hereinafter, the present invention will be described in detail.

The cosmetic composition having an antioxidant effect of the present invention is characterized in that it comprises a sulphurization, hyangbuja, gimo, and doujinshi extract as an active ingredient.

The lotus flower (Herbal Sauaaureae Involucratae, English name: Snow Lotus) used in the present invention is also called sublingual flower (雪 荷花), the mountain of the mountain river Uighur region, the Himalayan mountains and the Kulon of Tibet It is the only plant and medicinal plant collected only in a part of the mountain range. Its native habitats grow between the high and rugged rocks of the highlands over 4,000 m above sea level, and are difficult to harvest due to poor habitats, making it rare for only ancient emperors or gods to eat. For this reason it has long been called "the emperor's herb".

Sulling flowers usually take 6-8 years to bloom and bloom, and the flowering period is from July to August, so it is a very rare plant to wait several years to harvest. Breeding takes place through the excrement excreted by birds after ingesting sullenaceae. Females and males grow separately, but underlines are connected to each other by 5-6 m. It is a mysterious plant told by the legend that flowers can't be found in snow.

The shape of the sulyeonhwa is less than the lotus, but the petals are thin, narrow and long, and when the flowers are blooming, its straight and elegant appearance resembles a lotus, so it is called sulyeonhwa (雪 蓮花), and the appearance of the flower is beautiful. In addition to the pleasure of the crab, it contains a useful ingredient that helps a lot to the human body from ancient times is called the king Cho (Chinese chief of all plants).

Types of lotus flowers include cannon lotus flowers, cotton bean snow flowers, and scalloped flowers. Cannon sulyunhwa is called cheonsan sulyunhwa and has the best efficacy. It grows wild in the Tianshan Mountains of Xinjiang Uygur and is generally representative of this plant. This cannon canal is effective not only on flowers but also on leaves, stems, and roots. Also, the name of the head of the lotus flower is named after the flower part is like cotton, and grows mainly in the Himalaya Mountains of Tibet. Sleep perilla is mainly grown in Qinghai Province, and only the flower part is collected and used.

The main component of such sulphation contains 16 basic substances essential for the human body such as alkaloid, sterol, flavonoid, raculin, essential oil and polysaccharide.

Generally, sulphurization has an excellent nutrient tonic effect, and foods with nourishment tonic effect are effective only after a long time after drinking, whereas sulphurization is highly effective and does not mix with other foods. Ingestion alone can provide sufficient efficacy.

The hyangbuja used in the present invention is 10 to 30 cm in height of the rice paddy and perennial herb, the stem grows straight, the rhizome extends to the side, the tubers are formed at the end, the beard root falls. The flesh of the tuber is white with fragrance. The leaves are gathered from the root stem and have a string shape, and the bottom part is a leaf shop and surrounds the flower stem. Flowers bloom in July-August and form stalks of 20-30 cm in height. Small spikes are row-shaped, 20-40 flowers in 2 rows, red. Scales obliquely upward, narrow eggflower, with apical veins green and brown on both sides. Fruits are achene, long oval, black brown, pistil split into three.

The homeland of Hyangbuja is distributed all over the world, including Korea, China and Japan. The harvest time is August-October, and the main components are tuber root stem, essential oil (about 1%), tannin, coumarin, fat, sugar, etc. The main components of the essential oils are ciperene, ciferol, isociferol, A-ciferol, B-ciferol, ciferontundon, sugenol, sugettriol, ciferolone, cobuson, aikobuson and the like. In addition, essential oils (0.5 to 0.6%), alkaloids (0.21 to 0.24%), cardiac glycosides (0.6 to 0.8%), flavonoids (1.5%), carbohydrates (13%), and pectin (8-9%) Fats (2-3%), resins (about 4%), organic acids and the like.

Such hyangbuja in oriental medicine, dried tubers are called hyangbuja is used in molars (治 寒), warming agents (거), expectoration, asthma, pain, women's diseases. In Indonesia, pulmonary tuberculosis is used as an antitussive agent. In addition, Hyangbuja turns well and stops the pain, evens menstruation, has an excellent antioxidant effect, has antibacterial and antiparasitic action.

The hair used in the present invention is a perennial herb of the genus Lilium, and is 20 to 70 cm in height. Root stock is thick and stretches laterally, leaves gather at the end. The leaves are rope-shaped and the ends are thin like threads. The flowers bloom in June-July, and are gathered in the shape of barrels with two to three waters. The length is 7-8 mm, and the upper part is divided into six pieces. A flower stem comes out from the leaves and grows about 60 ~ 90 ㎝. Po is egg-shaped and long pointed, and 3 stamens. Fruits are capsules, long oval, 12 mm long, narrow at both ends.

The hair is distributed in Seoheung province of Hwanghaedo, Korea and China. The main ingredient is when the steroid saponin, aponin, is decomposed into the root stem, resulting in asporgenin and galactose. Root stems also include materiferrin (about 0.5%), isomangiferrin and nicotinic acid (20 mg%), pantopeic acid (1.6 mg%), mucus, tannins and the like. The leaves also contain 0.7% maturinine.

This type of hair has anti-inflammatory and anti-allergic effects, which helps to prevent skin itching and hypersensitivity, and has excellent anti-inflammatory and antioxidant effects.

The said fertilizer used in the present invention is a lump of peach seed, an egg-shaped uncompressed mass of slightly pointed one end, having a length of 1.2 cm, a diameter of 0.6 to 1.2 cm, and a thickness of 3 to 7 mm. When the peach ripens around July-August, the seeds are collected, the hard seed husks are broken, and Zain (子 仁) is taken out and used mainly as a herbal medicine. The cabbage skin is reddish brown and peels off well, and the ginseng is white, rich in oil, bitter, and chewable to give the direction of benzoaldehyde.

The main components of the phosphorus include amigdaline (1.5%), emulsine (3%), fatty oils (40-45%), other proteins, 24-methylenecycloartanol, Δ ⁷ -avenasterol, citrostadienol and the like. It contains. For medicinal, it is good to have a lot of self-sustaining and maintenance, and as an anti-inflammatory spoken blood bloating and pain in the lower abdomen, dysmenorrhea, dysmenorrhea, low back pain, constipation is mainly used. Also, in Chinese medicine prescription with Zain, Donugi Seunggitang, Rhubarb Moranpitang, Gyeji Bokryeonghwan, Haerheoltang, and Yunjangtang ).

Such indoin acts on the heart, liver and colon, and actively moves the blood to eliminate the blood, so menstrual irregularities, menstrual pain is mainly used. In addition, the skin is itchy and dry, or applied to blemishes and freckles, and is also good for constipation diarrhea. In addition, there is an anti-inflammatory effect and an antioxidant action.

The sulphurization, saengbuja, gimo, and doujin extract can be prepared in a conventional manner, for example, after washing the washed sulhwahwa, saengbuja, jimo, and doujin, here, purified water, 1,3-butyl It can be prepared by a conventional method of filtering and concentrating an extract stock extracted by adding a common solvent such as len glycol and ethanol.

The sulphurization, hyangbuja, gimo, and cabbage extract is preferably included in the cosmetic composition of the present invention in each of 0.01 to 30% by weight, more preferably 0.5 to 20% by weight, sulphurization, hyangbuja It is preferable that the total amount of extracts, hairs, and causal extracts is within 0.05 to 40% by weight of the cosmetic composition of the present invention. If the content is less than 0.05% by weight, there is a problem that it is difficult to expect a substantial antioxidant effect. If the content exceeds 40% by weight, the color is dark and difficult to mask the smell, and the economic value compared to the efficacy due to the cost decreases. Rather, there is a problem that can adversely affect the skin. More preferably, the content ratio of sulphurization, saengbuja, gimo, and causal extract is preferably mixed in a weight ratio of 1: 0.1-10: 0.1-10: 0.1-10.

The formulation of the cosmetic composition having an antioxidant effect containing the sulphurization, saengbuja, Jamo, and Doin extract of the present invention as an active ingredient is not particularly limited, and may be appropriately selected as desired. Specifically, the cosmetic composition may be prepared in the form of a flexible cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, pack, gel, lotion, ointment, patch, or spray.

Hereinafter, preferred examples are provided to help understanding of the present invention, but the following examples are merely to illustrate the present invention, and the scope of the present invention is not limited to the following examples.

EXAMPLE

Example 1

Dried sullenite, saengbuja, gimo, and caucus were washed with water and chopped finely. 1.5 kg of butylene glycol and 3.5 kg of ultrapure water were added per 1 kg of the mixture of the fine sulphurization, hyangbuja, gimo, and doin in a weight ratio of 1: 1: 1: 1, followed by extraction for 3-7 days. It was aged at 1 ° C. for 7 days. Then, the extract was first filtered through a 0.4 μm filter, passed through an ion exchange resin, filtered through a 0.2 μm filter, and then again filtered through a 0.1 μm filter to obtain final sulphation, Hyangbuja. , Jimmy, and Doin extracts were prepared.

(Cytotoxicity test)

Method of MTT test by culturing V79-4 cells (Chinese hamster, continuous cell line of lung tissue fibroblasts) to verify the primary safety of the preparations of sullenhwa, hyangbuja, gimo, and ginko extract (Reference: Mossman T. Rapid colorimetric assay for cellular growth & survival: application to proliferation & cytotoxicity assays.Journal of Immunological Methods , 1983, 65, 55-63 ) was performed to test the cytotoxicity, and the results are shown in Table 1 below. At this time, SLS (sodium lauryl sulfate) and squalane were used as a control.

TABLE 1

sample IC ₅₀ (%, w / v) SLS 0.005 Squalane 0.05 Sesame, Hyangbuja, Hair, and Doin Extract 5.00 IC ₅₀ (Inhibitory Concentration 50)-50% cell killing concentration

Through Table 1, the IC ₅₀ value of the sullenized, flavored, gimo, and cabbage extract used in the cosmetic composition of the present invention is 5.00, which is more than 1,000 times lower than cytotoxicity compared to SLS, and is excellent in safety. Cytotoxicity was lower by more than 100 times than that of the excellent safety.

(Allergy assessment (LLNA))

Experiments using acetone: olive oil (4: 1) as a transport medium were carried out to confirm the allergen incidence of the preparations of sullenhwa, hyangbuja, gimo, and ginko extract (Reference: Kimber (1990)) : Identification of contact allergens using the murine local lymph node assay, J. Appl. Toxicol. 10 (3), 173-180).

First, the sullenization, hyangbuja, gimo, and ginko extracts were prepared in 20%, 40%, and 60% solutions, and 50 μl was applied to both ears of the mouse (Balb / c) for 3 days. lymph nodes) were isolated. The isolated lymph nodes were pulverized into a single cell state, incubated for 24 hours with the addition of radioisotope [ ³ H] -thymidine, and then the dpm and amplification degree of cell proliferation were measured, and the results were measured. It is shown in Table 2 below.

TABLE 2

division Concentration (% by weight) Lymph node count (cells / mL × 107) dpm1 (average) S.I.2 (Amplitude) Acetone: Olive Oil (4: 1) 1.90 3011 Transportation Sesame, Hyangbuja, Hair, and Doin Extract 20 2.00 3650 1.20 40 2.05 3652 1.21 60 3.20 5739 1.90 [Note] 1. dpm (disintegraion per minute)-the amount of [3H] -methylthymidine is inserted into the cell 2. S.I. (stimulation index)-the average dpm of the sample divided by the average dpm of the control group

The allergy evaluation result indicates the lymphocyte amplification of the sample group compared to the control group, and if the amplification degree (SI) of the sample is 3 or more at one concentration and shows a tendency to increase in a concentration-dependent manner, it is regarded as an allergen. As shown, the sulphurization, fragrance extract, hair loss, and sinus extract used in the cosmetic composition of the present invention were shown to have an amplification degree (SI) of 2 or less, which is not allergenic.

(Skin irritation test)

Patch test using guinea pig (Guinea Pig) was performed for the skin irritation test of the preparations of sullenhwa, hyangbuja, gimo, and stalk extract (Reference: ① Draize, JH (1959): Dermal toxicity Assoc.Food and Drug officials, US.Appraisal of the safety of chemicals in Food, Drugs and Cosmetics., Pp46-59, Texas State Dept of Health, Austin, Texas. (2) Federal Register (1973): Method of testing primary irritant substances 38 (187): pp 1500-1541). Samples were tested by preparations of sulphated, saengbuja, gimo, and stalk extracts with different concentrations of oil-in-water emulsions.

First, the hair at the sample application site (back) was removed and acclimated to the environment for 24 hours to minimize skin irritation. Then, the sample application site was set (1.5 cm × 1.5 cm) to apply the sulphurization, fragrance, hair loss, and porcelain extract and gauze, and then sealed with a solid foil to prevent evaporation and loss of the sample. Fixed for 48 hours with elastic bandage. After fixing for 48 hours, the closed patch was removed, and the degree of stimulation was determined at 2 hours and 24 hours (48 hours and 72 hours after the patch), and the results are shown in Table 3 below. At this time, purified water was used as a control.

TABLE 3

division Concentration (%) Irritation index (PII *) Stimulus Control 0.50 Non-irritation Sesame, Hyangbuja, Hair, and Doin Extract 0.1 0.50 Microstimulation 1.0 0.58 Microstimulation 20 0.65 Microstimulation 30 0.90 Microstimulation [Primary] * PII-Primary cutaneous Irritation Index

As shown in Table 3, the sulphurization, fragrance, Gi, and Doin extract used in the cosmetic composition of the present invention are very safe, and even when used in an excessive concentration such as 30%, it can be confirmed that there is almost no skin irritation. there was.

(First irritation test on human body (closed patch))

1.0% by weight of the prepared sulphurized, flavored, gimo, and phosphorus extract, 1.0% by weight of sodium lauryl sulfate, and 10% by weight of ethanol, 1.0% by weight of sodium lauryl sulfate, 10% by weight of ethanol In order to find out, the first stimulation test was performed on the human body through a human patch test as follows. Fifty healthy men and women were tested according to CTFA guidelines (Ref .: The Cosmetic, Toility and Fragrance Association. Inc. Washington, D.C., 20036, 1991).

First, a sample containing 1.0% by weight of sulphurized, flavored, gimo, and phosphorus extract, 1.0% by weight of sodium lauryl sulfate, and 10% by weight of ethanol, 1.0% by weight of sodium lauryl sulfate in a Finn Chamber, and 20 μl of a 10% by weight ethanol solution was added dropwise, and the tape was placed on the test subject's back. Subsequently, after patching for 24 hours, after removing the patch and passing 4 hours again, the skin reaction of the test site was determined according to the following criteria, and the results are shown in Table 4. At this time, the degree of stimulation was measured according to the following equation (1).

Criteria - No erythema or unusual symptoms ± Slightly redder than the surroundings + Significantly redder than the surroundings ++ Severe redness and swelling than around

[Equation 2]

Stimulus = {((±) Number × 1) + ((+) Number × 2) + ((++) Number × 3)} / Number of Subjects

TABLE 4

sample The number of the subjects Judgment Result (persons) Stimulus ++ + ± - 1.0% by weight of sulphurized, scented, chymo, and saline extract + 1.0% by weight of sodium lauryl sulfate + 10% by weight of ethanol 50 - - 3 47 0.06 Sodium Lauryl Sulfate 1.0 wt% 50 2 8 12 28 0.68 10% by weight of ethanol 50 - - 10 40 0.20

Through Table 4, a sample of 1.0% by weight of sulphurization, saengbuja, gimo, and Doin extract, 1.0% by weight of sodium lauryl sulfate, and 10% by weight of ethanol used in the cosmetic composition of the present invention greatly alleviated irritation. It was confirmed that the ingredients safe to the skin.

(Free radical scavenging ability test)

In order to test the free radical scavenging ability of the sulphurization, saengbuja, gimosae, and causal extracts prepared by the 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) method (Blois, MS Nature 181, 1990 (1958)) ). DPPH is a relatively stable free radical that exhibits maximum absorption at 517 nm when present in the radical state and loses absorbance when erased. In this test, Sigma company was used as DPPH, and dissolved in methyl alcohol at a concentration of 0.15 mM.

First, the sullenization, saengbuja, gimo, and doujin extract prepared above were prepared at concentrations of 1-100 μl / mL, and 100 μl was added to each well of a 96-well plate. 100 μl of DPPH solution was added thereto, and the mixture was left at room temperature for 30 minutes, and then absorbance was measured at 540 nm using a Micro plate reader (BioTek EL-340). In this case, 100 μl of ascorbic acid was used as a control in place of the extracts of sullenization, saengbuja, gimo, and doin. As described above, the concentration of the sulfonylated extract when the absorbance of the treated group was half the absorbance of the control group was expressed as IC ₅₀ (inhibitory Concentration 50), and the results are shown in Table 5 below.

TABLE 5

division Ascorbic acid Sesame, Hyangbuja, Hair, and Doin Extract IC ₅₀ at 30 min 0.0005% 0.003% IC ₅₀ at 60 min - 0.003% IC ₅₀ at 17 hr - 0.002%

As shown in Table 5, the sulphurization, fragrance, Gi, and Doin extract used in the cosmetic composition of the present invention was found to be a very powerful free radical scavenger, and its durability was also excellent.

(SOD activation effect test)

Antioxidant activity is measured by radical generator (XOD / Xanthin) and Nitroblue terrazolium (NBT). Antioxidant Screening System with Superoxide Radical Scavenging Activity is applied to measuring the activity of Superoxide Dismutation (SOD), an enzyme that eliminates superoxide by dismutating superoxide. It is a method using terrazolium (NBT). Antioxidant activity was calculated by the degree of NBT reduction that was observed as a result of superoxide radical scavenging. In addition, the SOD activity effect of the above-mentioned sulphurization, hyangbuja, gimo, and causal extracts was measured by using the SOD activity calculation method in which the change in light absorbance was reduced by 50%.

First, 100 μl of 50 mM potassium phosphate buffer (pH 7.5), 50 μl of 16% Triton X-100, 50 μl of 1 mM EDTA, 150 μl of 1.2 mM Neotetrazolium chloride, Xanthin oxidase ) 100 μl, 1 mM hypoxanthin, 100 μl, Stop solution (3M TCA and 2.5N HCl in a 1: 1 mixture), sulphization, saengbuja, gimo, and saline extract-SOD 100 μl , And reacted at 37 ° C. for 20 minutes to measure absorbance at 540 nm. The results are shown in Table 6 below. In this case, 100 μl of potassium phosphate buffer was used as a control in place of the sullenization, saengbuja, gimo, and doin extract.

TABLE 6

sample Concentration (%) SOD (16.5 unit) 95.67 Sulwhahwa, Hyangbuja, Jimo, and Doin Extract 5.0% 81.83 Sulwhahwa, Hyangbuja, Jimo, and Doin Extract 1.0% 41.17 Sulwhahwa, Hyangbuja, Jimo, and Doin Extract 0.01% 4.09 Sulwhahwa, Hyangbuja and Balm Extract 5.0% 42.1 Sullenized, Bald and Guin Extract 5.0% 47.1 Sulwhahwa, Hyangbuja and Doin Extract 5.0% 45.5 Hyangbuja, Jimmy, and Doin Extract 5.0% 40.1

As shown in Table 6, the sulphurization, fragrance, Gi, and Doin extract used in the cosmetic composition of the present invention showed an excellent SOD activity effect of 81.83% at a concentration of 5.0% and 41.17% at a concentration of 1.0%. I could confirm it.

Example 2. Makeup

1.0% by weight of sulphurized, flavored, gimo, and phosphorus extract prepared in Example 1, glycerin 6.0% by weight, dipropylene glycol 4.0% by weight, hyaluronic acid 0.3% by weight, polyoxyethylene hydrogenated castor oil 0.1% by weight, polyethylene 0.1% by weight of oleyl ethyl, 5.0% by weight of ethanol, 0.15% of preservatives, a proper amount of perfume and pigments, and the remaining amount of purified water were mixed to prepare a lotion.

Example 3. Essence Preparation

3.0% by weight of sulphurized, saengbuja, gimo, and phosphorus extract prepared in Example 1, 1.0% by weight of cetostearyl alcohol, 1.0% by weight of self-emulsifying monostearic acid, 0.5% by weight of beeswax, 6.0% by weight of squalane, isocetyl Octanoate 3.0 wt%, dimethylsiloxane 0.3 wt%, monostearate sorbitan 0.5 wt%, monostearate polyethylene glycol 8.0 wt%, glycerin 5.0 wt%, propylene glycol 0.2 wt%, carboxypolymer 0.2 wt%, triethanolamine 0.22 wt% An essence was prepared by mixing%, an appropriate amount of preservative, a fragrance, and a pigment and a residual amount of purified water.

Example 4 Lotion Preparation

5.0% by weight of sulphurized, saengbuja, gimo, and phosphorus extract prepared in Example 1, 0.8% by weight of cetostearyl alcohol, 1.0% by weight of self-emulsifying monostearic acid, 0.5% by weight of beeswax, 0.5% by weight of stearic acid, liquid paraffin 8.0 wt%, squalane 4.0 wt%, macadamia oil 2.0 wt%, isocetyloctanoate 2.0 wt%, dimethylsiloxane 0.3 wt%, monostearate sorbitan 0.5 wt%, monostearate polyethylene glycol 1.0 wt%, glycerin 4.0 A lotion was prepared by mixing a weight percent, 4.0 weight percent propylene glycol, 4.0 weight percent betaine, 0.12 weight percent carboxypolymo, 0.15 weight percent triethanolamine, 0.25 weight percent preservative, appropriate amount of perfume and pigment, and the remaining purified water. .

Example 5. Cream Preparation

10.0% by weight of sulphurized, saengbuja, gimo, and phosphorus extract prepared in Example 1, cetostearyl alcohol 3.0% by weight, self-emulsifying monostearic acid 1.5% by weight, lipophilic monostearic acid 2.0% by weight, beeswax 0.5% by weight , 6.0% by weight of liquid paraffin, 8.0% by weight of squalane, 4.0% by weight of isocetyloctanoate, 4.0% by weight of purified jojoba oil, 0.3% by weight of dimethylsiloxane, 1.0% by weight of sorbitan monostearate, 1.2% by weight of polyethylene glycol monostearate, 10.0% by weight of glycerin, 5.0% by weight of 1,3-butylene glycol, 4.0% by weight of betaine, 0.06% by weight of xanthan gum, 0.10% by weight of triethanolamine, 0.25% by weight of preservative, appropriate amount of perfume and pigment, and remaining amount of purified water Mixing made a cream.

Example 6. Gel Preparation

15.0% by weight of sulphurized, saengbuja, gimo, and phosphorus extract prepared in Example 1, glycerin 7.0% by weight, 1,3-butylene glycol 5.0% by weight, ethanol 10.0% by weight, polyoxyethylene hardened castor oil 0.2% %, Carboxypolymer 0.3% by weight, triethanolamine 0.3% by weight, an appropriate amount of preservatives, fragrances, and a pigment and the residual amount of purified water were mixed to prepare a gel.

Example 7. Ointment Preparation

20.0% by weight of sulphurized, saengbuja, gimo, and phosphorus extract prepared in Example 1, cetostearyl alcohol 3.0% by weight, self-emulsifying monostearic acid 2.0% by weight, stearic acid 1.0% by weight, beeswax 4.0% by weight, squalane 8.0 Weight%, mono stearin glycerine 4.0 weight%, monostearate sorbitan 2.0 weight%, polysorbate 60 3.0 weight%, glycerin 5.0 weight%, 1,3-butylene glycol 4.0 weight%, appropriate amount of perfume and pigment, and balance Vaseline was mixed to prepare an ointment.

Although only described in detail with respect to the described embodiments of the present invention, it will be apparent to those skilled in the art that various modifications and variations are possible within the technical spirit of the present invention, it is natural that such variations and modifications belong to the appended claims. .

Claims (4)

A cosmetic composition having an antioxidant effect, wherein the cosmetic composition having an antioxidant effect, characterized in that it comprises sulphurization, fragrant, Gimo, and Doin extract as an active ingredient. The method of claim 1, The content of the sulphurization, hyangbuja, gimo, and scented extract is 0.01 to 30% by weight, respectively, and the total amount of the sulphurization, hyangbuja, jimo, and stalk extract is included in the cosmetic composition as 0.05 to 40% by weight. Cosmetic composition having an antioxidant effect. The method of claim 1, The ratio of the content of the sullenhwa, hyangbuja, gimo, and doujin extract ratio of 1: 0.1-10: 0.1-10: 0.1-10 cosmetic composition having an antioxidant effect, characterized in that. The method of claim 1, Cosmetic composition having an antioxidant effect, characterized in that the cosmetic composition is supple cosmetics, nourishing cosmetics, nourishing cream, massage cream, essence, pack, gel, lotion, ointment, patch, or spray.