KR20090087486A - 타입 2 당뇨병의 유전적 감수성 변이 - Google Patents

타입 2 당뇨병의 유전적 감수성 변이 Download PDF

Info

Publication number
KR20090087486A
KR20090087486A KR1020097013458A KR20097013458A KR20090087486A KR 20090087486 A KR20090087486 A KR 20090087486A KR 1020097013458 A KR1020097013458 A KR 1020097013458A KR 20097013458 A KR20097013458 A KR 20097013458A KR 20090087486 A KR20090087486 A KR 20090087486A
Authority
KR
South Korea
Prior art keywords
seq
markers
diabetes
type
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097013458A
Other languages
English (en)
Korean (ko)
Inventor
발거더 슈타인토어스도티어
구드마 토어레이프손
Original Assignee
디코드 제네틱스 이에이치에프
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 디코드 제네틱스 이에이치에프 filed Critical 디코드 제네틱스 이에이치에프
Publication of KR20090087486A publication Critical patent/KR20090087486A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/172Haplotypes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
KR1020097013458A 2006-11-30 2007-11-30 타입 2 당뇨병의 유전적 감수성 변이 Ceased KR20090087486A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IS8572 2006-11-30
IS8572 2006-11-30
IS8630 2007-04-04
IS8630 2007-04-04

Publications (1)

Publication Number Publication Date
KR20090087486A true KR20090087486A (ko) 2009-08-17

Family

ID=39102918

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097013458A Ceased KR20090087486A (ko) 2006-11-30 2007-11-30 타입 2 당뇨병의 유전적 감수성 변이

Country Status (8)

Country Link
US (1) US20100086921A1 (enExample)
EP (1) EP2099937A2 (enExample)
JP (2) JP2010510804A (enExample)
KR (1) KR20090087486A (enExample)
AU (1) AU2007326838B9 (enExample)
CA (1) CA2683909A1 (enExample)
SG (1) SG177148A1 (enExample)
WO (1) WO2008065682A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101459057B1 (ko) * 2014-02-27 2014-11-12 서울대학교병원 (분사무소) 임신성 당뇨병 이후 제2형 당뇨병 발병 예측 방법

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065544A2 (en) * 2006-09-11 2008-06-05 Mcgill University Genetic predictors of risk for type 2 diabetes mellitus
EP2451975A4 (en) * 2009-05-08 2013-08-14 Decode Genetics Ehf GENETIC VARIANTS CONTRIBUTING TO A RISK OF PROSTATE CANCER
US8796182B2 (en) 2009-07-10 2014-08-05 Decode Genetics Ehf. Genetic markers associated with risk of diabetes mellitus
JP5954724B2 (ja) * 2011-07-25 2016-07-20 国立研究開発法人理化学研究所 第6染色体短腕22領域または第9染色体長腕21領域の一塩基多型に基づく肥満の検査方法
CN105188692A (zh) * 2013-03-29 2015-12-23 国立大学法人熊本大学 2型糖尿病治疗剂
CN110218781B (zh) * 2019-04-23 2023-03-31 河北医科大学 21个微单倍型位点的复合扩增体系、下一代测序分型试剂盒及分型方法
WO2022203533A1 (ru) * 2021-03-25 2022-09-29 Владимир Валерьевич ВОЛОБУЕВ Способ оценки предрасположенности к различным формам сахарного диабета 2го типа

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
JPS60501339A (ja) * 1983-01-10 1985-08-22 ジエン−プロ−ブ インコ−ポレィテッド 生物を検出、同定又は定量する方法およびキット
US5288611A (en) * 1983-01-10 1994-02-22 Gen-Probe Incorporated Method for detecting, identifying, and quantitating organisms and viruses
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5424186A (en) * 1989-06-07 1995-06-13 Affymax Technologies N.V. Very large scale immobilized polymer synthesis
US5288644A (en) * 1990-04-04 1994-02-22 The Rockefeller University Instrument and method for the sequencing of genome
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5858659A (en) * 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
EP1080209A2 (en) * 1998-10-21 2001-03-07 Arch Development Corporation Methods of treatment of type 2 diabetes
US20030092019A1 (en) * 2001-01-09 2003-05-15 Millennium Pharmaceuticals, Inc. Methods and compositions for diagnosing and treating neuropsychiatric disorders such as schizophrenia
JP2006506988A (ja) * 2002-11-01 2006-03-02 デコード ジェネティクス イーエッチエフ. 染色体5q35に位置したヒトII型糖尿病遺伝子−SLIT−3
US20050196784A1 (en) * 2002-11-01 2005-09-08 Decode Genetics Ehf. Human Type II diabetes gene - Kv channel-interacting protein (KChIP1) located on chromosome 5
JP2008506379A (ja) * 2004-07-16 2008-03-06 オイ ユリラブ アェルテーデー 2型糖尿病の危険性の検出及び治療のための方法
US20070048751A1 (en) * 2005-02-15 2007-03-01 Jae-Heup Kim Method of diagnosing type II diabetes mellitus using multilocus marker, polynucleotide including marker associated with type II diabetes mellitus, and microarray and diagnostic kit including the polynucleotide
JP2008538177A (ja) * 2005-03-25 2008-10-16 ノバルティス アクチエンゲゼルシャフト 2型糖尿病の遺伝薬理学的診断のためのバイオマーカー
JP2006296270A (ja) * 2005-04-19 2006-11-02 Univ Of Tokyo Prkaa2遺伝子多型による2型糖尿病発症素因の検出方法
KR101374304B1 (ko) * 2005-06-20 2014-03-14 디코드 제네틱스 이에이치에프 타입 2 당뇨병의 위험에 대한 진단 마커인 tcf7l2유전자의 유전적 변이체

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101459057B1 (ko) * 2014-02-27 2014-11-12 서울대학교병원 (분사무소) 임신성 당뇨병 이후 제2형 당뇨병 발병 예측 방법

Also Published As

Publication number Publication date
EP2099937A2 (en) 2009-09-16
AU2007326838B9 (en) 2014-02-13
US20100086921A1 (en) 2010-04-08
WO2008065682A3 (en) 2008-10-16
AU2007326838B2 (en) 2014-01-30
JP2014097060A (ja) 2014-05-29
WO2008065682A2 (en) 2008-06-05
AU2007326838A1 (en) 2008-06-05
CA2683909A1 (en) 2008-06-05
SG177148A1 (en) 2012-01-30
JP2010510804A (ja) 2010-04-08

Similar Documents

Publication Publication Date Title
KR102149483B1 (ko) 예측변수 인자들을 이용하여 동정된 환자 부분 모집단에서 암 치료를 위한 마시티닙의 용도
KR102481305B1 (ko) 유전자에 기반한 염증성 장 질환의 진단
CA2936612A1 (en) Atf6 polymorphisms associated with myocardial infarction, method of detection and uses thereof
KR20110036608A (ko) 유방암 위험도 평가를 위한 유전적 변이
KR20170086027A (ko) 신경발달 장애에서의 행동을 개선시키기 위한 박테리아를 포함하는 조성물 및 방법
AU2016325030A1 (en) Novel biomarkers and methods of treating cancer
KR20130123357A (ko) 저산소증과 관련된 질환의 진단방법 및 키트
TW202536179A (zh) 用於調節ube3a-ats之化合物及方法
KR20090087486A (ko) 타입 2 당뇨병의 유전적 감수성 변이
CN101631876A (zh) 2型糖尿病的遗传易感性变体
WO2006022629A1 (en) Methods of identifying risk of type ii diabetes and treatments thereof
AU2018360287B2 (en) Method for determining the response of a malignant disease to an immunotherapy
TW202227102A (zh) 治療脂肪肝病之方法
EP1729930A2 (en) Methods for identifying risk of osteoarthritis and treatments thereof
WO2006022636A1 (en) Methods for identifying risk of type ii diabetes and treatments thereof
KR20170116009A (ko) 전립선암의 진단을 위한 신규한 rna-바이오마커 시그니처
KR102642320B1 (ko) 항암제에 대한 내성 진단용 조성물
WO2006022634A1 (en) Methods for identifying risk of type ii diabetes and treatments thereof
IL179831A (en) In vitro method for detecting the presence of or predisposition to autism or to an autism spectrum disorder, and an in vitro method of selecting biologically active compounds on autism or autism spectrum disorders
WO2018209358A2 (en) Systemic delivery of polypeptides
KR101474053B1 (ko) 골다공증 또는 골다공성 골절 발생 위험도 예측용 다형성 마커
US20030124536A1 (en) Diagnosis and treatment of vascular disease
KR102647919B1 (ko) App 돌연변이 세포 및 이의 이용
CN111556894A (zh) 用于调控gsk3b表达的寡核苷酸
EA048246B1 (ru) Способ лечения жировой болезни печени

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20090626

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20121122

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20140930

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20150413

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20140930

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I