KR20090053903A - 결정성 항진균 화합물 - Google Patents

결정성 항진균 화합물 Download PDF

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Publication number
KR20090053903A
KR20090053903A KR1020097004839A KR20097004839A KR20090053903A KR 20090053903 A KR20090053903 A KR 20090053903A KR 1020097004839 A KR1020097004839 A KR 1020097004839A KR 20097004839 A KR20097004839 A KR 20097004839A KR 20090053903 A KR20090053903 A KR 20090053903A
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KR
South Korea
Prior art keywords
chloro
quinazolin
propyl
methyl
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097004839A
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English (en)
Korean (ko)
Inventor
안토니오 카노바스 패러데스
야비에르 바트롤리 올피
엘리즈 몰린스 그라우
안나 로이그 세라
케빈 메이어
케이스 로리머
Original Assignee
스티펠 래버러토리즈, 인코포레이티드(어 델라웨어 코포레이션)
팔라우 파르마 에스에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39082545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20090053903(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06380225A external-priority patent/EP1887004A1/en
Priority claimed from EP07380186A external-priority patent/EP2009009A1/en
Application filed by 스티펠 래버러토리즈, 인코포레이티드(어 델라웨어 코포레이션), 팔라우 파르마 에스에이 filed Critical 스티펠 래버러토리즈, 인코포레이티드(어 델라웨어 코포레이션)
Publication of KR20090053903A publication Critical patent/KR20090053903A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097004839A 2006-08-07 2007-08-06 결정성 항진균 화합물 Ceased KR20090053903A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US83586306P 2006-08-07 2006-08-07
EP06380225A EP1887004A1 (en) 2006-08-07 2006-08-07 Crystalline forms of (1R,2R)-7-Chloro-3-[2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]quinazolin-4(3H)-one
US60/835,863 2006-08-07
EP06380225.0 2006-08-07
US92940807P 2007-06-26 2007-06-26
EP07380186A EP2009009A1 (en) 2007-06-26 2007-06-26 Crystalline antifungal compounds
EP07380186.2 2007-06-26
US60/929,408 2007-06-26

Publications (1)

Publication Number Publication Date
KR20090053903A true KR20090053903A (ko) 2009-05-28

Family

ID=39082545

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097004839A Ceased KR20090053903A (ko) 2006-08-07 2007-08-06 결정성 항진균 화합물

Country Status (17)

Country Link
US (2) US7879867B2 (enExample)
EP (2) EP2650291B1 (enExample)
JP (3) JP2010513222A (enExample)
KR (1) KR20090053903A (enExample)
CN (1) CN103232442B (enExample)
AR (1) AR062232A1 (enExample)
AU (1) AU2007284851B2 (enExample)
BR (1) BRPI0716026A2 (enExample)
CA (1) CA2658843A1 (enExample)
DK (1) DK2650291T3 (enExample)
ES (1) ES2652670T3 (enExample)
IL (2) IL196722A (enExample)
IN (1) IN2014MN01560A (enExample)
MX (1) MX2009001208A (enExample)
RU (1) RU2500679C2 (enExample)
TW (1) TWI426073B (enExample)
WO (1) WO2008021049A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018853A2 (en) 2004-08-19 2006-02-23 Hetero Drugs Limited Novel polymorphs of efavirenz
ES2584838T3 (es) 2006-04-05 2016-09-29 Opko Health, Inc Sal clorhidrato de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-espiro[4.5]decán-2-ona y procedimiento de preparación de la misma
ITMI20062449A1 (it) * 2006-12-19 2008-06-20 Dipharma Spa Forma cristallina di rabeprazolo sodico
EP2434892B1 (en) * 2009-05-29 2015-08-19 Palau Pharma, S.A. Azole antifungal compositions
KR20120079054A (ko) * 2009-07-10 2012-07-11 에볼바 아게 디인 조성물
CN105503870A (zh) * 2009-08-14 2016-04-20 欧科生医股份有限公司 神经激肽-1拮抗剂的静脉内制剂
US9435692B2 (en) 2014-02-05 2016-09-06 Lam Research Corporation Calculating power input to an array of thermal control elements to achieve a two-dimensional temperature output
US11039620B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US9622483B2 (en) 2014-02-19 2017-04-18 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
US11039621B2 (en) 2014-02-19 2021-06-22 Corning Incorporated Antimicrobial glass compositions, glasses and polymeric articles incorporating the same
GB201410407D0 (en) * 2014-06-11 2014-07-23 Univ Dundee And Syngene Internat Ltd Plc And Consejo Superior De Investigaciones Cientificas And Med Treatment of chagas disease
EA025187B1 (ru) * 2015-04-17 2016-11-30 Тагир Аббасели оглы Сулейманов Производное дитиокарбамата 2-((4-(4-метилпиперазин-1-ил)фенил)амино)-2-оксоетил4-этилпиперазин-1-карбодитиоат, обладающее антифунгальной активностью
JP2025505889A (ja) 2021-12-22 2025-03-03 パラウ ファルマ，エス．エル．ユー． 多粒子アルバコナゾール組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293500A1 (en) 1987-06-01 1988-12-07 American Cyanamid Company 3-heteroalkyl-2,4.quinzaoline-diones
GB8819308D0 (en) 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
TW218017B (enExample) 1992-04-28 1993-12-21 Takeda Pharm Industry Co Ltd
TW297813B (enExample) * 1993-09-24 1997-02-11 Takeda Pharm Industry Co Ltd
CA2134417A1 (en) 1993-12-22 1995-06-23 Katsumi Itoh Optically active azole derivatives, their production and use
DK0783501T3 (da) * 1995-08-02 2001-01-29 Uriach & Cia Sa J Pyrimidonderivater med anti-fungal aktivitet
AU6119798A (en) 1997-03-05 1998-09-22 Takeda Chemical Industries Ltd. Crystalline form of a bis 1,2,4-triazole compound
ES2159488B1 (es) * 2000-03-07 2002-04-16 Uriach & Cia Sa J Procedimiento para la preparacion de derivados de pirimidona con actividad antifungica.

Also Published As

Publication number Publication date
US8258296B2 (en) 2012-09-04
IN2014MN01560A (enExample) 2015-05-08
AU2007284851A1 (en) 2008-02-21
CN103232442A (zh) 2013-08-07
RU2500679C2 (ru) 2013-12-10
EP2049504A2 (en) 2009-04-22
AU2007284851B2 (en) 2013-05-09
TWI426073B (zh) 2014-02-11
ES2652670T3 (es) 2018-02-05
BRPI0716026A2 (pt) 2013-08-06
EP2049504A4 (en) 2010-09-22
CA2658843A1 (en) 2008-02-21
WO2008021049A2 (en) 2008-02-21
TW200823197A (en) 2008-06-01
WO2008021049A3 (en) 2008-12-31
US20110092702A1 (en) 2011-04-21
WO2008021049A9 (en) 2008-10-30
IL196722A (en) 2016-10-31
US20080076787A1 (en) 2008-03-27
AR062232A1 (es) 2008-10-22
JP2014012673A (ja) 2014-01-23
EP2650291B1 (en) 2017-10-04
DK2650291T3 (en) 2017-10-23
IL196722A0 (en) 2009-11-18
JP2010513222A (ja) 2010-04-30
EP2650291A1 (en) 2013-10-16
RU2009104959A (ru) 2010-08-20
MX2009001208A (es) 2009-04-14
JP2015193642A (ja) 2015-11-05
IL248216B (en) 2018-03-29
US7879867B2 (en) 2011-02-01
CN103232442B (zh) 2015-01-21

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