KR20090045148A - 구획 증후군의 치료에 사용하기 위한 항분비 단백질 - Google Patents
구획 증후군의 치료에 사용하기 위한 항분비 단백질 Download PDFInfo
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- KR20090045148A KR20090045148A KR1020087029120A KR20087029120A KR20090045148A KR 20090045148 A KR20090045148 A KR 20090045148A KR 1020087029120 A KR1020087029120 A KR 1020087029120A KR 20087029120 A KR20087029120 A KR 20087029120A KR 20090045148 A KR20090045148 A KR 20090045148A
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| SG171602A1 (en) | 2006-04-27 | 2011-06-29 | Lantmaennen As Faktor Ab | Use of antisecretory factors for treating intraocular hypertension |
| CN101460187B (zh) | 2006-04-27 | 2014-11-05 | 兰特门内阿斯-法克托尔公司 | 抗分泌蛋白的进一步医疗应用 |
| US9962424B2 (en) | 2007-04-27 | 2018-05-08 | Lantmännen As-Faktor Ab | Use of antisecretory factors (AF) for optimizing cellular uptake |
| US8901083B2 (en) | 2008-11-25 | 2014-12-02 | Temple University | Administration of angiocidin for the treatment of leukemia |
| EP2396024A4 (en) * | 2009-02-11 | 2013-02-27 | Lantmaennen As Faktor Ab | USE OF ANTISECRREATORY FACTORS (AF) FOR OPTIMIZATION OF CELLULAR ABSORPTION |
| JP6707121B2 (ja) | 2015-07-10 | 2020-06-10 | ラントメネン・アーエス−ファクトール・アーベー | 高含量のａｆ−１６を有する卵黄の産生方法 |
| MX2019000594A (es) | 2016-07-18 | 2019-09-09 | Lantmaennen As Faktor Ab | Factor anti-secretor 17. |
| JP7217760B2 (ja) * | 2018-06-28 | 2023-02-03 | ラントメネン・メディカル・アーベー | 急性呼吸不全の治療および／または予防の使用のための抗分泌因子 |
| EP3855935A1 (en) | 2018-09-28 | 2021-08-04 | Lantmännen Functional Foods AB | A consumable product comprising malted wheat |
| EP3855934A2 (en) | 2018-09-28 | 2021-08-04 | Lantmännen Functional Foods AB | A consumable product comprising malted dehulled oat |
| CN115605214A (zh) | 2020-03-26 | 2023-01-13 | 兰特门内保健食品公司（Se） | 用于促进身体活动恢复的包含麦芽化谷物的可消耗产品 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH682716A5 (de) * | 1992-01-13 | 1993-11-15 | Christian Fricker | Benzo-Pyrone und/oder Dobesilat-Calcium enthaltende pharmazeutische Zusammensetzung. |
| US5585401A (en) | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| SE508609C2 (sv) | 1995-08-24 | 1998-10-19 | Rural Patent Svenska Ab | Antisekretorisk faktor - dess aminosyrasekvens, nubleinsyrasekvens och användning |
| SE506486C2 (sv) * | 1996-11-20 | 1997-12-22 | Svenska Lantmaennen Riksfoerbu | Födoämne som vid förtäring inducerar antisekretoriska proteiner |
| SE513496C2 (sv) * | 1998-12-17 | 2000-09-18 | Rural Patent Svenska Ab | NASP-berikad äggula samt dess användning |
| US7662169B2 (en) * | 2000-09-05 | 2010-02-16 | Wittmann Dietmar H | Prosthesis and method for lowering abdominal pressure |
| GB0322645D0 (en) * | 2003-09-26 | 2003-10-29 | Melacure Therapeutics Ab | Use of antisecretory factor peptides |
| AU2007244005B2 (en) | 2006-04-27 | 2012-08-02 | Lantmannen As-Faktor Ab | Further medical uses of antisecretory protein |
| CN101460187B (zh) | 2006-04-27 | 2014-11-05 | 兰特门内阿斯-法克托尔公司 | 抗分泌蛋白的进一步医疗应用 |
| WO2009052478A1 (en) * | 2007-10-19 | 2009-04-23 | Trustees Of Boston University | Metabolic and cardioprotection by the myokine follistatin-like 1 polypeptide |
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