KR20090038921A - 허혈 관련 의학적 증상을 치료하는 폴리펩타이드, 이를 암호화하는 폴리뉴클레오타이드, 및 이의 치료 용도 - Google Patents

허혈 관련 의학적 증상을 치료하는 폴리펩타이드, 이를 암호화하는 폴리뉴클레오타이드, 및 이의 치료 용도 Download PDF

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KR20090038921A
KR20090038921A KR20097004288A KR20097004288A KR20090038921A KR 20090038921 A KR20090038921 A KR 20090038921A KR 20097004288 A KR20097004288 A KR 20097004288A KR 20097004288 A KR20097004288 A KR 20097004288A KR 20090038921 A KR20090038921 A KR 20090038921A
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glu
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에얄 브라이트바르트
리브나트 밴지오
레쉬프 탈
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바스큘라 바이오제닉스 리미티드
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KR20097004288A 2006-07-31 2007-07-31 허혈 관련 의학적 증상을 치료하는 폴리펩타이드, 이를 암호화하는 폴리뉴클레오타이드, 및 이의 치료 용도 Withdrawn KR20090038921A (ko)

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US83415706P 2006-07-31 2006-07-31
US60/834,157 2006-07-31

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KR20090038921A true KR20090038921A (ko) 2009-04-21

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KR20097004288A Withdrawn KR20090038921A (ko) 2006-07-31 2007-07-31 허혈 관련 의학적 증상을 치료하는 폴리펩타이드, 이를 암호화하는 폴리뉴클레오타이드, 및 이의 치료 용도

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US (3) US20100298226A1 (https=)
EP (1) EP2051988A4 (https=)
JP (2) JP5513885B2 (https=)
KR (1) KR20090038921A (https=)
CN (2) CN101516902B (https=)
AU (1) AU2007280017B2 (https=)
CA (1) CA2658972C (https=)
MX (1) MX2009001157A (https=)
NZ (1) NZ574410A (https=)
WO (1) WO2008015675A2 (https=)
ZA (1) ZA200900581B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071740B2 (en) 2000-11-17 2011-12-06 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
CA2463816C (en) 2001-10-19 2014-07-08 Vascular Biogenics Ltd. Polynucleotide constructs, pharmaceutical compositions and methods for targeted downregulation of angiogenesis and anticancer therapy
CN101516902B (zh) 2006-07-31 2012-08-08 脉管生物生长有限公司 多肽和其编码多聚核苷酸及它们在治疗缺血相关医学病症中的应用
JP2011526892A (ja) * 2008-06-30 2011-10-20 アンジオブラスト システムズ，インコーポレーテッド 併用療法を使用した眼疾患及び過剰血管新生の治療
US20130209450A1 (en) 2010-01-05 2013-08-15 Yael Cohen Compositions and Methods for Treating Glioblastoma GBM
WO2011083464A2 (en) 2010-01-05 2011-07-14 Vascular Biogenics Ltd. Methods for use of a specific anti-angiogenic adenoviral agent
SG182490A1 (en) * 2010-01-12 2012-08-30 Vascular Biogenics Ltd Methods of producing adenovirus vectors and viral preparations generated thereby
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells
BR112015008612A2 (pt) 2012-10-17 2017-09-26 Vascular Biogenics Ltd métodos de tratamento utilizando adenovirus
WO2014118643A2 (en) 2013-02-04 2014-08-07 Vascular Biogenics Ltd. Methods of inducing responsiveness to anti-angiogenic agent
EP2968448A4 (en) * 2013-03-15 2016-02-17 Univ Pennsylvania COMPOSITIONS USING HYPOXY-INDUCIBLE FACTOR 1-ALPHA AND METHOD OF USE THEREOF
WO2015092024A2 (en) * 2013-12-20 2015-06-25 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
CN107722114A (zh) * 2016-07-07 2018-02-23 胡国田 一种多肽及其应用

Family Cites Families (13)

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Publication number Priority date Publication date Assignee Title
CN1073420A (zh) * 1991-12-18 1993-06-23 济南火柴厂 一种无硫无铬火柴的制造方法
US6124131A (en) 1998-08-25 2000-09-26 The Johns Hopkins University School Of Medicine Mutant hypoxia inducible factor-1 HIF-1
US20020048794A1 (en) * 2000-08-07 2002-04-25 Lorenz Poellinger Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von Hippel-Lindau tumor suppressor protein
US7067649B2 (en) 2000-11-17 2006-06-27 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
AU2003222427B8 (en) 2000-11-17 2010-04-29 Vascular Biogenics Ltd. Promoters exhibiting endothelial cell specificity and methods of using same
ES2425321T3 (es) * 2000-11-17 2013-10-14 Vascular Biogenics Ltd. Promotores que muestran especificidad por células endoteliales y métodos de utilización de los mismos
US6849718B2 (en) * 2001-03-20 2005-02-01 Dana Farber Cancer Institute, Inc. Muteins of hypoxia inducible factor alpha and methods of use thereof
US7193053B2 (en) * 2003-04-25 2007-03-20 United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hypoxia-inducible factor 1alpha variants and methods of use
CN101516902B (zh) 2006-07-31 2012-08-08 脉管生物生长有限公司 多肽和其编码多聚核苷酸及它们在治疗缺血相关医学病症中的应用
WO2011083464A2 (en) 2010-01-05 2011-07-14 Vascular Biogenics Ltd. Methods for use of a specific anti-angiogenic adenoviral agent
US20130209450A1 (en) 2010-01-05 2013-08-15 Yael Cohen Compositions and Methods for Treating Glioblastoma GBM
SG182490A1 (en) 2010-01-12 2012-08-30 Vascular Biogenics Ltd Methods of producing adenovirus vectors and viral preparations generated thereby
WO2012052878A1 (en) 2010-10-19 2012-04-26 Vascular Biogenics Ltd. Isolated polynucleotides and nucleic acid constructs for directing expression of a gene-of-interest in cells

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