KR20090031938A - 방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 - Google Patents
방향성 진화로 촉매 작용을 최적화시킨 키메라 징크 핑거 리컴비나제 Download PDFInfo
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- KR20090031938A KR20090031938A KR1020097002444A KR20097002444A KR20090031938A KR 20090031938 A KR20090031938 A KR 20090031938A KR 1020097002444 A KR1020097002444 A KR 1020097002444A KR 20097002444 A KR20097002444 A KR 20097002444A KR 20090031938 A KR20090031938 A KR 20090031938A
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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- C—CHEMISTRY; METALLURGY
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- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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| KR20150070120A (ko) * | 2012-09-04 | 2015-06-24 | 더 스크립스 리서치 인스티튜트 | 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 |
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| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| MY160435A (en) * | 2008-06-12 | 2017-03-15 | Univ Putra Malaysia | A novel antiviral peptide against avian influenza virus h9n2 |
| WO2010042894A1 (en) * | 2008-10-09 | 2010-04-15 | The Regents Of The University Of California | NOVEL NUCLEIC ACID CONSTRUCTS CONTAINING ORTHOGONAL SITE SELECTIVE RECOMBINASES (OSSRs) |
| GB2467167B (en) * | 2009-01-26 | 2013-09-11 | Algentech Sas | Gene targeting in plants |
| NZ598457A (en) | 2009-08-03 | 2014-06-27 | Recombinetics Inc | Methods and compositions for targeted gene modification |
| US20130005590A1 (en) * | 2011-06-06 | 2013-01-03 | The Regents Of The University Of California | Synthetic biology tools |
| WO2013163628A2 (en) * | 2012-04-27 | 2013-10-31 | Duke University | Genetic correction of mutated genes |
| US9738879B2 (en) | 2012-04-27 | 2017-08-22 | Duke University | Genetic correction of mutated genes |
| WO2014012165A1 (en) | 2012-07-19 | 2014-01-23 | Alethia Biotherapeutics Inc. | Anti-siglec-15 antibodies |
| US10793867B2 (en) * | 2013-03-15 | 2020-10-06 | Monsanto Technology, Llc | Methods for targeted transgene-integration using custom site-specific DNA recombinases |
| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| JP7085716B2 (ja) | 2013-06-05 | 2022-06-17 | デューク ユニバーシティ | Rnaガイド遺伝子編集及び遺伝子調節 |
| CN105765592B (zh) | 2013-09-27 | 2019-12-17 | 科德克希思公司 | 用于酶变体的自动筛选的方法、装置和系统 |
| JP6309086B2 (ja) * | 2013-09-27 | 2018-04-11 | コデクシス, インコーポレイテッド | 構造ベース予測モデリング |
| JP6303195B2 (ja) * | 2013-11-20 | 2018-04-04 | 国立研究開発法人産業技術総合研究所 | 細菌による機能的外来タンパク質の製造方法 |
| AU2015218821B2 (en) * | 2014-02-21 | 2019-01-24 | President And Fellows Of Harvard College | De novo design of allosteric proteins |
| WO2016081924A1 (en) | 2014-11-20 | 2016-05-26 | Duke University | Compositions, systems and methods for cell therapy |
| EP3256487A4 (en) | 2015-02-09 | 2018-07-18 | Duke University | Compositions and methods for epigenome editing |
| CN104789555A (zh) * | 2015-04-29 | 2015-07-22 | 江南大学 | 一种基于合成单链dna文库进化基因表达调控元件的方法 |
| CN108138164B (zh) * | 2015-08-21 | 2022-05-10 | 孟山都技术公司 | 基因组基因座的增强的重组 |
| JP6905755B2 (ja) | 2015-08-25 | 2021-07-21 | デューク ユニバーシティ | Rnaガイド型エンドヌクレアーゼを使用してゲノム工学における特異性を改善する組成物および方法 |
| EP4089175A1 (en) | 2015-10-13 | 2022-11-16 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| MX2018005377A (es) | 2015-11-30 | 2018-11-09 | Univ Duke | Dianas terapeuticas para la correccion del gen de la distrofina humana por edicion genica y metodos de uso. |
| CN106011162A (zh) * | 2016-01-27 | 2016-10-12 | 浙江大学 | 大肠杆菌细胞内原位进化目标蛋白质的新方法 |
| WO2017180915A2 (en) | 2016-04-13 | 2017-10-19 | Duke University | Crispr/cas9-based repressors for silencing gene targets in vivo and methods of use |
| EP3487523B1 (en) | 2016-07-19 | 2023-09-06 | Duke University | Therapeutic applications of cpf1-based genome editing |
| CN111727259B (zh) | 2017-12-01 | 2024-04-19 | 编码治疗公司 | 工程化的dna结合蛋白 |
| CN109979591B (zh) * | 2019-03-12 | 2021-01-01 | 众安信息技术服务有限公司 | 一种基于图神经网络分析斑块进展因子的方法及装置 |
| CN114174520B (zh) * | 2019-05-29 | 2025-07-08 | 编码治疗公司 | 用于选择性基因调节的组合物和方法 |
| US11987791B2 (en) | 2019-09-23 | 2024-05-21 | Omega Therapeutics, Inc. | Compositions and methods for modulating hepatocyte nuclear factor 4-alpha (HNF4α) gene expression |
| CN110868598B (zh) * | 2019-10-17 | 2021-06-22 | 上海交通大学 | 基于对抗生成网络的视频内容替换方法及系统 |
| TW202132565A (zh) * | 2019-11-01 | 2021-09-01 | 美商聖加莫治療股份有限公司 | Gin重組酶變異體 |
| WO2025006468A2 (en) | 2023-06-26 | 2025-01-02 | University Of Hawaii | Evolved integrases and methods of using the same for genome editing |
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| CN1303930A (zh) * | 1999-10-27 | 2001-07-18 | 上海博容基因开发有限公司 | 一种新的多肽——锌指蛋白57和编码这种多肽的多核苷酸 |
| GB0222229D0 (en) * | 2002-09-25 | 2002-10-30 | Univ Glasgow | Mutant recombinases |
| CA2562552C (en) * | 2004-04-30 | 2014-03-11 | Poetic Genetics, Llc | Hybrid recombinases for genome manipulation |
| WO2006078431A2 (en) * | 2004-12-22 | 2006-07-27 | The University Of Iowa Research Foundation | Compositions and methods related to modified retroviral vectors for restricted, site specific integration |
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| KR20150070120A (ko) * | 2012-09-04 | 2015-06-24 | 더 스크립스 리서치 인스티튜트 | 표적화된 바인딩 특이도를 갖는 키메라 폴리펩타이드들 |
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| JP2009542228A (ja) | 2009-12-03 |
| US8685687B2 (en) | 2014-04-01 |
| EP2046806A2 (en) | 2009-04-15 |
| EP2046806A4 (en) | 2009-10-21 |
| CA2667974A1 (en) | 2008-01-10 |
| WO2008006028A3 (en) | 2008-12-24 |
| US20100086532A1 (en) | 2010-04-08 |
| CN101484462A (zh) | 2009-07-15 |
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