KR20080111798A - Cosmetic composition for alleviating the dark circle and the darkness around the eyes - Google Patents

Abstract

A cosmetic composition for alleviating dark circle and darkness around eyes is provided to accelerate the blood flow of skin and to relieve the dark circle and darkness around eyes caused by skin aging, ultraviolet ray and stress. A cosmetic composition for alleviating dark circle and darkness around eyes comprises gingko leaf extract and N-acetyl-D-glucosamine. The gingko leaf extract is obtained by using a solvent extraction method using an extraction solvent selected from a group consisting of water, C1-4 anhydrous or hydrated lower alcohol, acetone, ethylacetate, chloroform, butylacetate and 1,3- butylene glycol; a supercritical fluid extraction method; or a sonication extraction method.

Description

Cosmetic composition for improving dullness and dark circles {Cosmetic Composition for Alleviating the Dark Circle and the Darkness around the Eyes}

The present invention contains a ginkgo leaf extract and N-acetylglucosamine (N-Acetyl Glucosamine) to effectively remove the dull and dark circles caused by ultraviolet rays, stress, skin aging, poor blood flow, etc. It relates to a composition.

Human skin becomes dull and dark easily due to UV rays, environmental pollution and stress. In particular, these problems occur more around the eyes, which is called the dark circle (Dark Circle). Dark circles are a phenomenon in which eyes look dark and appear shaded. When the shade under the eyes becomes darker, the impression becomes darker than it actually is, and it looks helpless and tired, so it is sometimes called 'tired eyes' in the West.

There are many causes of dark circles. (1) when fat accumulates and has a yellowish color, (2) microvessels appear in thin skin and have a bluish color; (3) pale or thin around the eyes; (4) melanin pigment In exceptional cases, (5) pigmentation due to dermatitis or the like occurs around the eyes. In addition, if the dark circle is not enough sleep, or before and after menstruation, and stress continues, blood circulation around the eyes is not smooth and the fat under the eye accumulate more and the symptoms worsen. To date, many cosmetics have been marketed under the concept of eliminating dark circles under the eyes, and improving dark circles is a concern for many women. Because of these women's concerns, many cosmetics manufacture and sell cosmetics that eliminate women's dark circles. Most products, however, focus on inhibiting skin pigmentation or strengthening blood vessels by eliminating dark circles. In the present invention, when the ginkgo biloba extract and N-acetylglucosamine, which are well known to promote blood circulation, are simultaneously added, it is confirmed that the dark circle is effectively removed, and a prescription containing the same is applied to the present invention.

The present inventors make a cosmetic composition by mixing various plant extracts and apply it to the eyes of women, and when the ginkgo leaf extract and N-acetylglucosamine (N-AcetylGlucosamine) are added at the same time, it is confirmed that there is a very excellent dark circle removal effect. The invention regarding the cosmetic composition containing was completed.

Accordingly, it is an object of the present invention to provide a cosmetic composition for improving dullness and dark circles, including ginkgo leaf extract and N-acetylglucosamine (N-acetyl-D-glucosamine).

In addition, another object of the present invention is to provide a cosmetic method, characterized in that by applying the cosmetic composition to the human skin to improve the appearance of dull and dark circles.

Other objects and advantages of the present invention will become apparent from the following examples and claims.

The present invention provides a cosmetic composition for improving dullness and dark circles, including ginkgo leaf extract and N-acetylglucosamine (N-acetyl-D-glucosamine).

Ginkgo biloba as an active ingredient of the cosmetic composition of the present invention has the following characteristics.

Ginkgo biloba ) is a genus of Ginkgoaceae, and its leaves are rosacea, tea veins, and fan-shaped flowers, divalent flowers, flowering in May (male flowers), fruits in ovate, silvery white, and open in October. The branch is composed of long and short branches, the stem is gray brown, and the shape is deciduous coniferous tree, and the tree is conical. The place of origin is the eastern part of China, the size is 15-30m, and the growing area is the whole area.

Ginkgo biloba is a very old tree that has existed to this day. It has strong resistance to pests and diseases, and grows well in Korea because of its good ability to reproduce and live. Ginkgo biloba has been used for medicinal and edible food since ancient times. Especially, ginkgo biloba leaves contain various aliphatic alcohols and aliphatic ketones, ginkgolide and flavonoids, and flavone glycosides, and among the flavonoids, flavonoids It is known that non-glycosides such as glycoside, flavonol, and biflavon are mainly contained.

The ginkgo biloba extract used in the present invention may be obtained through various methods known in the art, preferably (a) water, (b) anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (eg, methanol, ethanol) , Propanol, butanol, and the like), (c) acetone, (d) ethyl acetate, (e) chloroform or (f) 1,3-butylene glycol were obtained from the leaves of Ginkgo biloba. More preferably, the extraction solvent is water. Ginkgo biloba as the material for extraction may be used by drying it or may be used as it is. As a drying method, natural drying or a hot air drying method can be used.

In the present invention, ginkgo biloba extract was prepared using ultrasonic waves. In other words, the ultrasonic membrane is used to destroy the cell membrane and extract the active ingredient in the cell. When the frequency range is 20 KHz or less, the extraction efficiency is lowered because the cell membrane is not completely destroyed. Heat is generated during the process, and also causes a change of intracellular material. In the present invention, the frequency range is set to 20-40 KHz.

The preparation method of the ginkgo biloba extract is described with reference to the following specific preparation of the present invention as follows: The dried ginkgo biloba leaves are placed in an ultrasonic extractor, the frequency is adjusted to 24KHz, extracted at room temperature for 3 hours, and the extract is filtered to filter the filtrate. It was evaporated under reduced pressure at 40 ℃ or less to obtain the ginkgo leaf extract.

On the other hand, it is apparent to those skilled in the art that the extract of the present invention can be obtained not only the above-described extraction solvent, but also the ginkgo leaf extract having substantially the same effect using other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-mentioned extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the ginkgo biloba extract of the present invention.

Ginkgo biloba extract of the present invention may be prepared in a powder state by an additional process such as distillation under reduced pressure, freeze drying or spray drying.

Next, N-acetylglucosamine, which is an active ingredient included in the cosmetic composition of the present invention, is a molecular formula C ₆ H ₁₃ NO ₆ , which is collectively referred to as hexamine together with galactosamine because of six carbons. . In addition, it is a colorless needle crystal, decomposes at 110 ℃, is a strong base material soluble in water. Naturally, it is widely distributed as a component of polysaccharides such as chitin, bacterial cell walls, and mucopolysaccharides that make up the cartilage and skin of animals. In addition, human blood or mucus contains a large amount of protein bound to this sugar, and the cell membranes of red blood cells contain glycolipids bound to these sugars and are prepared by hydrolyzing chitin.

Recently, N-acetylglucosamine has been used as a cosmetic raw material for skin moisturizing cosmetics (domestic patent No. 2000-23040), wrinkle improving agent (domestic patent No. 2006-7017794), moisturizing, elasticity, luster improving agent (domestic patent No. 2005-7006063) It is used as a health food material and beauty health food material (Domestic Patent No. 2000-23040) that helps to strengthen joints and cartilage.

The present inventors have found that the exfoliation effect is excellent in addition to the known efficacy of N-acetylglucosamine, and when used simultaneously with the component having a blood circulation promoting effect, it was confirmed that the dark circle improvement effect was very excellent and completed the present invention.

The cosmetic composition of the present invention by using a ginkgo leaf extract having a blood circulation promoting effect and N-acetylglucosamine having a keratin peeling effect at the same time, the dark circle improvement effect and the improvement of dullness is maximized.

Ginkgo biloba extract and N-acetylglucosamine of the present invention can achieve the effect by topical application or spraying on the skin. Therefore, according to a preferred aspect of the present invention, the composition of the present invention is a cosmetic composition such as nutrition lotion (lotion) and flexible lotion (skin), nutrition cream, massage cream, essence, pack or pharmaceutical compositions such as spray and ointment It may be prepared in the form.

Ginkgo biloba extract of the present invention is included in 0.0001-20% by weight relative to the total weight of the cosmetic composition, preferably 0.001-10% by weight.

Next, N-acetylglucosamine is included in an amount of 0.01-10.0% by weight, preferably 0.1-5.0% by weight, based on the total weight of the cosmetic composition.

When the composition of the present invention is formulated in cosmetics, the components included in the cosmetic composition of the present invention include components commonly used in cosmetic compositions in addition to ginkgo biloba extract and N-acetylglucosamine as active ingredients, such as antioxidants, stabilizers , Conventional adjuvants such as solubilizers, vitamins, pigments and flavorings, and carriers.

The cosmetic composition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations and sprays, and the like, but are not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, and microcrystals are used as carrier components. Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

In addition, the present invention provides a cosmetic method, characterized in that the application of the cosmetic composition of the present invention to the skin of the human eye to improve dullness and dark circles.

The cosmetic method of the present invention refers to all cosmetic methods for applying the cosmetic composition of the present invention to human skin. That is, all the methods known in the art for applying the cosmetic composition to the skin belong to the cosmetic method of the present invention.

The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in combination with other cosmetic compositions other than the present invention. In addition, the cosmetic composition with excellent skin protection effect according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's skin condition or taste.

When the cosmetic composition of the present invention is a soap, surfactant-containing cleansing or surfactant-free cleansing formulation, it may be wiped off, peeled off or washed with water after application to the skin. As a specific example, the soap is liquid soap, powdered soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towels and cleansing pack, the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.

When the cosmetic method including the ginkgo biloba extract and N-acetylglucosamine according to the present invention is applied to human skin, it can effectively improve dullness and dark circles by promoting blood circulation in the eyes.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Preparation Example 1 Preparation of Ginkgo Leaf Extract

1 kg of ginkgo biloba powder pulverized into 200 mesh was placed in an ultrasonic extractor containing 3 liters of distilled water, the frequency was adjusted to 24 KHz, extracted at room temperature for 3 hours, the extract was filtered, and the filtrate was evaporated under reduced pressure at 40 ° C. or lower. 76 g of extract was obtained. This extract was used again in the present invention with a final concentration of 1 g / 100 mL.

Preparation Example 2 Preparation of Ginkgo Biloba Extract and N-Acetylglucosamine-Containing Cosmetics

A cream formulation containing Ginkgo biloba extract and N-acetylglucosamine is as follows.

N-acetylglucosamine was purchased from MMP Corporation (United States of America) and used. Ginkgo biloba extract used was prepared in Preparation Example 1.

ingredient Control Comparative Example 1 Comparative Example 2 Example 1 Ginkgo Leaf Extract - 1.0 - 1.0 N-acetylglucosamine - - 1.0 1.0 Lipophilic monostearate 2.0 2.0 2.0 2.0 Cetearyl Alcohol 2.2 2.2 2.2 2.2 Stearic acid 1.5 1.5 1.5 1.5 Beeswax 1.0 1.0 1.0 1.0 Polysorbate 60 1.5 1.5 1.5 1.5 Sorbitan stearate 0.6 0.6 0.6 0.6 Cured Vegetable Oil 1.0 1.0 1.0 1.0 Squalane 3.0 3.0 3.0 3.0 Mineral oil 5.0 5.0 5.0 5.0 Trioctanoine 5.0 5.0 5.0 5.0 Dimethicone 1.0 1.0 1.0 1.0 Sodium magnesium silicate 0.1 0.1 0.1 0.1 glycerin 5.0 5.0 5.0 5.0 Betaine 3.0 3.0 3.0 3.0 Triethanolamine 1.0 1.0 1.0 1.0 Sodium hyaluronate 4.0 4.0 4.0 4.0 Methylparaben 0.2 0.2 0.2 0.2 incense 0.05 0.05 0.05 0.05 Distilled water Remaining amount Remaining amount Remaining amount Remaining amount Sum 100 100 100 100

The content units in the table are by weight.

Test Example 1.   Evaluation of Blood Circulation Promoting Effect Using LDPI

In order to evaluate the blood circulation promoting effect on the skin of the compositions of Examples, Comparative Examples and Comparative Examples of the present invention prepared in Preparation Example 2, the degree of blood circulation in the skin was measured using a Laser Doppler Perfusion Imager (LDPI). Measured. LDPI is a well-known and still used device for measuring blood circulation in the skin. It is a very sensitive device that can measure not only the speed and amount of blood in the capillaries of the skin, but also the flow in the small arteries and veins. to be. In the constant temperature and humidity room where the LDPI is located, the arm was refreshed with soap for 30 minutes after washing with water, and the initial value was measured in both arms using LDPI. A total of 20 participants (10 males and 10 females) participated in the experiment, and the average change was measured by measuring blood changes in 5 sites per arm.

Blood flow change value sample Blood flow changes (before and after use) Control cream 0.028 ± 0.0018 Comparative Example 1 0.141 ± 0.0025 Comparative Example 2 0.035 ± 0.0014 Example 1 0.147 ± 0.0016

Experimental results showed that the skin blood flow in the product containing ginkgo biloba extract (Comparative Examples 1 and 1) was increased.

Test Example 2 . Evaluation of skin exfoliation promoting effect

For the compositions of Examples, Comparative Examples and Comparative Examples of the present invention prepared in Preparation Example 2, the exfoliation promoting effect was evaluated through a practical test. 20 30-40 year old women were selected for the product prepared in Preparation Example 2, and the surface of the skin was dyed using 5% DHA (Dihydroxy Acetone) solution on the right upper arm and four parts, followed by Preparation, Comparative and Comparative Examples. The cream was applied twice every morning. After 1 week, L-value (Lightness-skin brightness) of each part is measured and the average value is obtained. After 2 weeks, the L-value of each part is calculated again, and finally the change of L value (ΔL) is obtained.

Skin keratin exfoliation promoting effect of the present invention cosmetic sample ΔL change (1 week) ΔL change (2 weeks) Control cream 0.98 ± 0.001  2.13 ± 0.0012 Comparative Example 1 1.02 ± 0.002 2.35 ± 0.003 Comparative Example 2 2.56 ± 0.003 6.23 ± 0.005 Example 1 2.66 ± 0.005 6.16 ± 0.001

According to the experimental results, the product containing N-acetylglucosamine (Comparative Example 2 and Example 1) showed a higher skin keratin exfoliation promoting effect than the control.

Test Example 3.  Dark Circle Mitigation Effect Test

The under-eye dullness and dark circle improvement effect of the cosmetics of this invention were evaluated through the actual use test. Each of the products prepared in Preparation Example 2 (20 women with dark circles) were used twice a day (morning and evening) for 8 weeks, and the skin color change of each subject was observed. Skin color change was measured by Mexameter (C + K, Germany), and the value of ΔL after 8 weeks (L value after 8 weeks-L value after 0 weeks) was compared. The dark circle (Dark circle) improvement effect based on this evaluation is shown in Table 4 below.

Dark Circle Improvement Effect (Evaluation) sample ΔL value Control cream 2.45 Comparative Example 1 6.23 Comparative Example 2 6.35 Example 1 18.71

According to the experimental results, the cosmetic composition of the present invention (Example 1) containing both ginkgo biloba extract and N-acetylglucosamine at the same time, and a comparative example containing nothing and Comparative Examples 1 and 2 containing ginkgo biloba extract and N-acetylglucosamine alone Compared with the improvement of dark circle, the skin irritation was not observed in most of the subjects who applied the cosmetic to the skin.

The present invention relates to a cosmetic composition containing both ginkgo biloba extract and N-acetylglucosamine at the same time, the cosmetic composition of the present invention promotes blood flow to the skin, the skin under the dullness and dark circles caused by aging, UV, stress, etc. It effectively alleviates and has no skin irritation.

Claims (7)

Cosmetic composition for improving dullness and dark circles, including ginkgo leaf extract and N-acetyl-glucosamine (N-acetyl-D-glucosamine). The extract of claim 1, wherein the ginkgo biloba extract is selected from the group consisting of (a) water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, acetone, ethyl acetate, chloroform, butyl acetate and 1,3-butylene glycol Cosmetic composition, characterized in that extracted by using a solvent extraction method, (b) supercritical extraction method or (c) ultrasonic extraction method using a solvent. The cosmetic composition according to claim 1, wherein the ginkgo biloba extract is contained in an amount of 0.0001-20% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the N-acetylglucosamine has a keratin exfoliation effect.      The cosmetic composition according to claim 1, wherein the N-acetylglucosamine is contained in an amount of 0.01-10.0% by weight based on the total weight of the cosmetic composition.       According to claim 1, wherein the cosmetic composition is selected from cosmetic composition or ointment of the lotion, gel, water-soluble liquid, cream, essence, oil-in-water (O / W) type or water-in-oil (W / O) type formulation. Cosmetic composition to be. A cosmetic method according to claim 1 to 6, wherein the cosmetic composition of the present invention is applied to human skin to improve eye dullness and dark circles.