KR20080103206A - Composition of cosmetic using natural complex extract as anti-oxidant agent - Google Patents

Abstract

A cosmetic composition is provided to show an excellent antioxidant effect by containing a nature composite having a superior oxygen-resistant, to be safe in comparison with synthetic materials, to be used as a natural anti-oxidation agent by showing no stimulation and to obtain an excellent antioxidant cosmetic when is added in the cosmetic materials. A cosmetic composition contains a nature composite having a superior oxygen-resistant. The nature composite comprises black soybean, chrysanthemi Flos, bletillae Rhizoma, artemisia princeps, asparagus cochinchinensis and an extract of Scutellariae radix and is extracted by a solvent including water, methanol and ethanol. The cosmetic composition is used as shampoo, rinse, toner, spray, lotion, skin, cream, pack and hair product.

Description

Composition of cosmetic using natural complex extract as anti-oxidant agent

 Figure 1 shows the results of DPPH experiment of the natural complex with excellent antioxidant, Figure 2 shows the results of measuring the SOD-like activity, Figure 3 shows the Xanthine oxidase inhibitory effect.

The present invention relates to a cosmetic composition containing a natural complex having an excellent antioxidant effect, as a cosmetic composition containing black soybeans, gamguk, baekyuk, wormwood, astronomical dong, golden extracts using a natural extract with excellent skin affinity, skin compatibility It is intended to provide a cosmetic that can significantly impart an antioxidant effect and moisturizing to the skin.

  Antioxidants are added into the lipid system to prevent the formation of various undesirable compounds due to oxidation. Various oxidation products produced by oxidation are known to be related to human aging by damaging DNA or causing cancer. In general, butylated hydroxy anisol (BHA) and butylated hydroxy toluene (BHT), which are widely used as phenolic synthetic antioxidants, have been widely used due to their effectiveness, economy, and safety, but they can be used for excessive ingestion time, gastric mucosa, It is known to cause serious toxic effects on the lungs, kidneys, circulatory system, etc., and therefore, the development of safe alternative antioxidants is required. Therefore, research on natural antioxidants that are harmless to humans and excellent in antioxidant power has been conducted for a long time, and most of the natural antioxidants reported so far are plant-derived. The antioxidant compounds of most plants are mainly polyphenols, and natural antioxidants have some of their primary activity, the primary antioxidant activity (free radical scavenger). Therefore, by exploring radical scavenging function from plant extracts, natural antioxidants can be developed.

  Black Bean is rich in unsaturated fatty acids (linolenic acid), vitamin E, potassium and amino acids. Pigment of black soybean is known as a biologically active substance with strong anti-aging effect, mutation suppression effect, cholesterol lowering effect and anticancer effect. It removes cholesterol from the walls of the blood vessels and the antioxidant saponins cleanse the blood vessels along with unsaturated fatty acids, preventing blood vessel aging and cancer. In addition, jeongjeongjeong, hypertension, atherosclerosis improvement, fever, detoxification, fatigue recovery, diuretic effect is shown. In the field of cosmetics, it has the effect of preventing skin aging by the antioxidant and skin regeneration effect, and keeps the skin transparent and glossy by nourishing the skin smoothly. Clearing the blood and strengthening the blood vessels prevents skin problems.

  The chrysanthemum is a chrysanthemum, with short hairs as a whole grass, and the stem is 60-90cm in height and is black and thin. Leaves are dark green, alternate, petioles, egg-shaped, usually divided into quills and pointed ends. Cracks are long oval and have serrated teeth. In September-October, two flowers bloom in the shape of a mountain on the top of the stem. It has the effect of strengthening blood pressure, antiviral and antibacterial effect. It can keep skin shiny and clean by anti-inflammatory, anti-allergic effect and blood circulation improvement, and it is excellent in inhibiting tyrosinase activity and makes skin clear and elastic. Antioxidant effect Absorbs ultraviolet rays and prevents skin aging and maintains skin elasticity.

  White is flat triangular ovate, 2 ~ 3cm long, 1 ~ 2cm in diameter. The outer surface is yellowish white to yellowish brown, and the upper end has stem marks or leaf traces. The vagina is keratin and hard. There is no smell and taste is bitter and mucus. Excellent moisture retention prevents skin dryness and itching. It also helps wound healing and skin health with astringent hemostatic effect and antibacterial action. It's a great way to treat inflammation and boost your skin, and to help treat skin diseases such as carbuncles and swelling.

  The wormwood is a shrub species of the genus Asteraceae, distributed in the fields all over the country. It is 60 ~ 120cm high, with ridges on the main stem, the whole is covered with cobweb-like hairs, and roots extend to the side and shoots emerge from several places. It warms blood vessels and meridians to fight cold and stop cold pain. It is effective for astringent hemostasis, analgesic Luha of women, bleeding during pregnancy, abdominal pain, earth and sand. It exhibits wound healing and cell protective activity, cell proliferation and regeneration effect, inhibits and delays skin aging with excellent antioxidant activity, and gives refreshing and safety to skin through excellent astringent action.

  Astronomical dong belongs to the family Liliaceae and grows at the foot of the beach. It is wild in Jeonnam, Mokpo and Ulleungdo, and is distributed in Japan, Yugu, Taiwan, and China. This plant is called astronomical dong in the sense that it is similar to McMoon-Dong due to its luxuries. When the effect of the effect, there is a soothing effect to make the skin scars and troubles safe, excellent antibacterial effect, gives the skin a smooth and soft feeling. It also has antioxidant and moisturizing effects.

  Gold belongs to Lamiaceae, native to northern China in East Asia, and is found in mountainous regions of Korea. It is distributed in East Siberia, Mongolia, China, and Manchuria. Roots include 4-5% of barricalin, bicarrain, wogonin, wogonoside, 7-methoxy-bicalane, neobicalane, 7-methoxynorwogonin, oroxylon A, and school capflavon. . In addition, there are pyrocatechin-based tannins, beta sitosterol, resins, and essential oils. The leaves include wogonoside, cartamidine, and isocartamidine. Therefore, due to the rich Baikal, Baikallein shows an excellent active oxygen scavenging ability, there is an effect to prevent skin aging due to ultraviolet rays. It is excellent for skin whitening effect by preventing skin sedation, excellent anti-inflammatory, antibacterial effect, tyrosinase activity inhibition, and UV protection, and prevents skin damage.

  As such, many studies have been conducted on substances having excellent antioxidant and other effects, but it is difficult to make safety such as discoloration, discoloration, pH, viscosity of formulation, and sunlight, which are disadvantages of natural materials. It's hard to get the effect.

The present invention is provided in order to efficiently solve the problems of the prior art as described above, as a basic experiment of the present invention to explore the cosmetic natural material with excellent antioxidant effect, aloe, yugeunpi, black soybeans, gamguk, white weight, wormwood, cheonmundong Natural, such as golden, machi, Eoseongcho, Ganoderma lucidum, Shin Yi Hwa, Pogongyoung, Yulpi, camellia, phytoncide, willow, birch, potato, licorice, red ginseng, brown algae, guar gum, lettuce, sage, loofah, iris, gardenia And the herbal materials were selected to complete the natural complex under optimal conditions, and applied to the cosmetics and conducted an antioxidant experiment, the cosmetic composition excellent in antioxidants was completed.

The present invention relates to a cosmetic composition containing a natural complex having an excellent antioxidant effect, as a cosmetic composition containing black soybeans, gamguk, baekyuk, wormwood, astronomical dong, golden extracts using a natural extract with excellent skin affinity, skin compatibility It is intended to provide a cosmetic that can significantly impart an antioxidant effect and moisturizing to the skin.

  Antioxidants are added into the lipid system to prevent the formation of various undesirable compounds due to oxidation. Various oxidation products produced by oxidation are known to be related to human aging by damaging DNA or causing cancer. Butylated hydroxy anisol (BHA) and butylated hydroxy toluene (BHT), which are widely used as phenolic synthetic antioxidants, have been widely used because of their effectiveness, economics, and safety, but they have been used to avoid excessive ingestion time, gastrointestinal mucosa, and lungs. It is known to cause serious toxic effects in the kidneys, kidneys, circulatory system, etc., and therefore, the development of safe alternative antioxidants is required. Therefore, research on natural antioxidants that are harmless to humans and excellent in antioxidant power has been conducted for a long time, and most of the natural antioxidants reported so far are plant-derived. The antioxidant compounds of most plants are mainly polyphenols, and natural antioxidants have some of their primary activity, the primary antioxidant activity (free radical scavenger). Therefore, by exploring radical scavenging function from plant extracts, natural antioxidants can be developed.

  Black Bean is rich in unsaturated fatty acids (linolenic acid), vitamin E, potassium and amino acids. Pigment of black soybean is known as a biologically active substance with strong anti-aging effect, mutation suppression effect, cholesterol lowering effect and anticancer effect. It removes cholesterol from the walls of the blood vessels and the antioxidant saponins cleanse the blood vessels along with unsaturated fatty acids, preventing blood vessel aging and cancer. In addition, jeongjeongjeong, hypertension, atherosclerosis improvement, fever, detoxification, fatigue recovery, diuretic effect is shown. In the field of cosmetics, it has the effect of preventing skin aging with the antioxidant and skin regeneration effect, and it keeps the skin transparent and shiny by smoothly supplying nutrition to the skin. Clearing your blood and strengthening your blood vessels will help prevent skin problems.

  The chrysanthemum is a chrysanthemum, with short hairs as a whole grass, and the stem is 60-90cm in height and is black and thin. Leaves are dark green, alternate, petioles, egg-shaped, usually divided into quills and pointed ends. Cracks are long oval and have serrated teeth. In September-October, two flowers bloom in the shape of a mountain on the top of the stem. It has the effect of strengthening blood pressure, antiviral and antibacterial effect. It can keep skin shiny and clean by anti-inflammatory, anti-allergic effect and blood circulation improvement, and it is excellent in inhibiting tyrosinase activity and makes skin clear and elastic. Antioxidant effect Absorbs ultraviolet rays and prevents skin aging and maintains skin elasticity.

  White is flat triangular ovate, 2 ~ 3cm long, 1 ~ 2cm in diameter. The outer surface is yellowish white to yellowish brown, and the upper end has stem marks or leaf traces. The vagina is keratin and hard. There is no smell and taste is bitter and mucus. Excellent moisture retention prevents skin dryness and itching. It also helps wound healing and skin health with astringent hemostatic effect and antibacterial action. It's a great way to treat inflammation and boost your skin, and to help treat skin diseases such as carbuncles and swelling.

  The wormwood is a shrub species of the genus Asteraceae, distributed in the fields all over the country. It is 60 ~ 120cm high, with ridges on the main stem, the whole is covered with cobweb-like hairs, and roots extend to the side and shoots emerge from several places. Warm blood and meridians to stop the cold and stop the cold, the effect of astringent hemostasis, analgesic Luha's wife, bleeding during pregnancy, abdominal pain, earth and sand is effective. It exhibits wound healing and cell protective activity, cell proliferation and regeneration effect, inhibits and delays skin aging with excellent antioxidant activity, and gives refreshing and safety to skin through excellent astringent action.

  Astronomical dong belongs to the family Liliaceae and grows at the foot of the beach. It is wild in Jeonnam, Mokpo and Ulleungdo, and is distributed in Japan, Yugu, Taiwan, and China. This plant is called astronomical dong in the sense that it is similar to McMoon-Dong due to its luxuries. When the effect of the effect, there is a soothing effect to make the skin scars and troubles safe, excellent antibacterial effect, gives the skin a smooth and soft feeling. It also has antioxidant and moisturizing effects.

  Gold belongs to Lamiaceae, native to northern China in East Asia, and is found in mountainous regions of Korea. It is distributed in East Siberia, Mongolia, China, and Manchuria. Roots include 4-5% of barricalin, bicarrain, wogonin, wogonoside, 7-methoxy-bicalane, neobicalane, 7-methoxynorwogonin, oroxylon A, and school capflavon. . In addition, there are pyrocatechin-based tannins, beta sitosterol, resins, and essential oils. The leaves include wogonoside, cartamidine, and isocartamidine. Therefore, due to the rich Baikal, Baikallein shows an excellent active oxygen scavenging ability, there is an effect to prevent skin aging due to ultraviolet rays. It is excellent for skin whitening effect by preventing skin sedation, excellent anti-inflammatory, antibacterial effect, tyrosinase activity inhibition, and UV protection, and prevents skin damage.

  As such, many studies have been conducted on substances having excellent antioxidant and other effects, but it is difficult to make safety such as discoloration, discoloration, pH, viscosity of formulation, and sunlight, which are disadvantages of natural materials. It's hard to get the effect.

2-3-1-2 Technical Issues

  The present invention is provided in order to efficiently solve the problems of the prior art as described above, as a basic experiment of the present invention to explore the cosmetic natural material with excellent antioxidant effect, aloe, yugeunpi, black soybeans, gamguk, white weight, wormwood, cheonmundong Natural, such as golden, machi, Eoseongcho, Ganoderma lucidum, Shin Yihwa, Pogongyoung, Yulpi, camellia oil, phytoncide, willow, birch, potato, licorice, red ginseng, brown seaweed, guar gum, lettuce, sage, loofah, iris, gardenia And the herbal materials were selected to complete the natural complex under optimal conditions, and applied to the cosmetics and conducted an antioxidant experiment, the cosmetic composition excellent in antioxidants was completed.

2-3-2 Composition of the Invention

  The present invention provides a cosmetic composition containing an extract having an antioxidant activity in order to achieve the above object, it includes those extracted from black beans, gamguk, white weight, wormwood, astronomical dong, golden leaves, roots, berries, flower parts do. Extraction solvents include the use of hot water, methanol, ethanol and the like. In addition, the cosmetic composition of the present study includes the basic cosmetic lotion, skin, lotion, cream, pack and hair products such as shampoo, rinse, toner, spray and the like.

  The natural complex of the present invention is sufficiently dried and ground to finely pulverize, and the volume of water, methanol and ethanol of 1 to 50 times, preferably about 1 to 20 times, of the sample is used as a solvent, preferably 70 to 100%. Reflux-cooled extraction with methanol and ethanol at about 10 to 100 ° C., preferably at 50 to 90 ° C. for about 3 to 5 days, preferably 12 to 3 days, or from 1 to 10 at 40 ° C. After 7 days, preferably 1 to 3 days to extract and extract, the extract was cooled and then filtered and the filtrate was concentrated using a rotary vacuum concentrator and then lyophilized to prepare a natural compound with excellent antioxidant.

  The natural composite of the present invention is a cosmetic composition constituting 0.1 to 20% wt, preferably 1 to 10% wt, based on the total weight of the composition. If the natural compound is less than 0.01%, there is almost no antioxidant effect, and if it is more than 20%, it cannot impose cosmetic taste due to the color of the natural compound itself. It has a disadvantage.

 In order to measure the antioxidant effect of the natural complex of the present invention, the electron donating ability, SOD-like activity (Superoxide Dismutase-like Activity), nitrite (nitrite-scavenging ability) scavenging effect was confirmed, cosmetics, hair products and color products for the antioxidant effect It can be used in various ways. Products that can be added with natural complexes include skin care lotions, skins, lotions, creams, shampoos, rinses, toners and sprays.

Hereinafter, embodiments of the present invention will be described in more detail a part of the present invention, but the content of the present invention is not limited thereto.

Example 1 Natural complex extract manufacturing

Hot Water Extract  Produce

After completely drying, 200 g of finely pulverized natural compound was added to 2000 kg of purified water, extracted by boiling in an extractor equipped with a cooling condenser, filtered through a 200 mesh filter cloth, filtered three times, cooled at room temperature, filtered, and filtered using a rotary vacuum concentrator. After concentration and freeze-drying, 6.8 g of extract could be obtained.

Ethanol Extract Preparation

After drying completely, 200 g of finely pulverized natural compound was added to 2000 kg of 70% ethanol, extracted by dipping at room temperature for 3 days, filtered through 200 mesh filter cloth, repeated three times, concentrated using a rotary vacuum concentrator, concentrated, and freeze dried. g extracts were obtained.

Example 2. Electron donating ability test

Example 1 Measurement of the electron donating ability of the sample was performed for DPPH (1,1-Diphenyl-2-pycryl-hydrazyl), a relatively stable free radical of each extract, according to the method of Blois (Blois, MS Nature 181, 1190 (1958)). The hydrogen donating effect was measured. 1 ml of 2 * 104M DPPH (dissloved in 99% ethanol) was added to 2 ml of the sample at a constant concentration, and the mixture was reacted at 37 ° C. for 30 minutes by vortex mixing for about 10 seconds. The reaction solution was measured for absorbance at 517 nm using an absorption spectrophotometer. The electron donating effect expressed the difference in absorbance before and after sample addition as a percentage. Figure 1 shows the electron donating ability measurement results, it was confirmed that the excellent electron donating ability is high.

Example 3. SOD-like activity

Example 1 SOD-like activity of the sample was measured by measuring the amount of pyrogallol that catalyzes the conversion of hydrogen peroxide (H 2 O 2) according to Marklund's method. After 0.2 ml of tris-HCl buffer (50 mM tris (hydrozymethyl) amino-methane + 10 mM EDTA, pH 8.5) and 0.2 ml of 7.2 mM pyrogallol were added to 0.2 ml of sample at a constant concentration for 10 minutes, 1 ml of 1N HCl was added to stop the reaction. The amount of oxidized pyrogallol in the reaction solution was measured at 420 nm using a UV / Vis spectrophotometer. SOD-like activity was expressed as a percentage (%) of the difference in absorbance between the addition and no addition of the sample solution. Figure 2 shows the results of measuring the SOD-like activity, it was able to confirm the effect of excellent SOD-like activity.

Example 4. Nitrite-scavenging ability scavenging ability

Nitrite (NaNO 2) scavenging activity was measured according to the method of Kato et al. The sample of Example 1 was added to 2 ml of 1 mM NaNO 2 solution, and 0.1 N HCl (pH 1.2) and 0.2 M citrate buffer were used. After the pH of the reaction solution was adjusted to 6.0, the volume of the reaction solution was adjusted to 10 ml for 1 hour at 37 ° C., and 1 ml Tlr was added thereto, and 5 ml of 2% acetic acid was added thereto. Then, 0.4 ml of Griess reagent (A: B = 1: 1, A: 1% sulfanilic acid in 30% acetic acid, B: 1% naphthylamine in 30% acetic acid) was added, followed by vortex mixing and reaction at room temperature for 15 minutes. The reacted samples were measured for absorbance at 520 nm using a spectrophotometer. Figure 3 shows the results of measuring the nitrite scavenging ability, it was confirmed that the effect of the nitrite scavenging effect of the natural complex is excellent.

Example 5. Skins manufacturer

Raw material name Weight% (w / w) Purified water To. 100 glycerin 5.0 Hyaluronic acid 1.0 Butylene glycol 3.0 ethanol 5.0 antiseptic 0.3 incense 0.02 Polyoxyethylene Cured Castor Oil 0.5 silicon 0.2 Natural complex 5

Example 6. Essence manufacturer

Raw material name Weight% (w / w) Cetostearyl alcohol 1.0 Stearic acid 1.0 Beeswax 0.5 Squalane 7.0 Sorbitan monosulfate 0.5 Dimethylsiloxane 0.3 glycerin 5 Butylene glycol 3 antiseptic 0.3 incense 0.05 Carboxy polymer 0.06 Triethanolamine 0.06 Xanthan gum 0.05 Pigment 0.6 Natural complex 5 Purified water To. 100

Example 7. Cream manufacturers

Raw material name Weight% (w / w) Cetostearyl alcohol 3.0 Stearic acid 1.5 Beeswax 1.0 Squalane 8.0 Sorbitan monosulfate 1.0 Dimethylsiloxane 0.3 Jojoba You 3.0 Isocetyloctanoate 4.0 Polyethylene glycol monostearate 1.2 Betaine 1.0 antiseptic 0.3 incense 0.05 Carboxy polymer 0.12 Triethanolamine 0.12 Xanthan gum 0.05 Pigment 0.6 Natural complex 10 Purified water To. 100

Example 8. Shampoo manufacturers

Raw material name Weight% (w / w) Sodium lauryl sulfate 40.0 Cocamide Diey 2.0 Propylene glycol 3.0 Citric acid 0.1 incense 0.5 NaCl 1.5 EDTA 2Na 0.1 antiseptic 0.2 Natural complex 10 Purified water To. 100

Example 9. Stimulation test

Skin irritation tests were performed using Examples 5, 6, 7, and 8. The skin irritation test was performed using a method such as Waggoner, Matsumura, and Aberer, and a patch and a skin absorbing device were applied to the skin of the inner arm area for 24 hours. After patching, the skin reaction was visually confirmed, and the criterion was determined based on the judgment of the International Contact Dermatitis Study Group (Table 5). Ten men and women in their 20s and 30s were tested.

As a result of the study, it was found that out of 10 volunteers, dermatological problems such as redness, mixing, and itching did not occur.

Reaction Expression Negative - Imperfection erythema ± Erythema + Small blister, Papule, Edema ++ Big blister, necrosis +++

The natural complex of the present invention exhibits an excellent effect on the antioxidant, such as electron donating ability, SOD-like activity, nitrite (sitrite-scavenging ability) scavenging ability, and can be used as a natural antioxidant by showing a safe and non-irritant compared to synthetic materials, When added to cosmetics, excellent antioxidant cosmetics can be obtained. In addition, it can provide an effective and innovative cosmetic composition by removing the antioxidant which is one of the causes of skin aging and atopic dermatitis when added to skin aging and atopy-related products.

Claims (3)

Cosmetic composition with excellent antioxidant effect, containing natural complex of black soybeans, gamguk, white worm, wormwood, astronomical dong, and golden extract The cosmetic composition according to claim 1, wherein the natural compound is extracted with a solvent such as water, methanol, ethanol, and the like, and contains 0.1% to 20% wt based on the total weight of the composition. The cosmetic composition according to claim 1 or 2, wherein the product of the composition comprises a lotion, skin, lotion, cream, pack and hair products such as shampoo, rinse, toner, spray and the like.

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