KR20080095879A - 신규 아자사이클릴-치환된 아릴티에노피리미디논, 이의 제조 방법 및 이의 약물로서의 용도 - Google Patents
신규 아자사이클릴-치환된 아릴티에노피리미디논, 이의 제조 방법 및 이의 약물로서의 용도 Download PDFInfo
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- KR20080095879A KR20080095879A KR1020087020096A KR20087020096A KR20080095879A KR 20080095879 A KR20080095879 A KR 20080095879A KR 1020087020096 A KR1020087020096 A KR 1020087020096A KR 20087020096 A KR20087020096 A KR 20087020096A KR 20080095879 A KR20080095879 A KR 20080095879A
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- Prior art keywords
- alkyl
- compound
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- alkoxy
- independently
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- 238000000034 method Methods 0.000 title claims description 126
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- 229940079593 drug Drugs 0.000 title description 12
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- 150000001875 compounds Chemical class 0.000 claims description 257
- 229910052757 nitrogen Inorganic materials 0.000 claims description 144
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 140
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- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 94
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 92
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- 125000005842 heteroatom Chemical group 0.000 claims description 75
- 229910005965 SO 2 Inorganic materials 0.000 claims description 73
- 125000001424 substituent group Chemical group 0.000 claims description 73
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- 125000002950 monocyclic group Chemical group 0.000 claims description 59
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 58
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 49
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- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 22
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 20
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- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 15
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 15
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- 125000006574 non-aromatic ring group Chemical group 0.000 claims description 15
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- YCIPQJTZJGUXND-UHFFFAOYSA-N Aglaia odorata Alkaloid Natural products C1=CC(OC)=CC=C1C1(C(C=2C(=O)N3CCCC3=NC=22)C=3C=CC=CC=3)C2(O)C2=C(OC)C=C(OC)C=C2O1 YCIPQJTZJGUXND-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Hematology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| DE102006007046 | 2006-02-15 | ||
| DE102006007046.1 | 2006-02-15 |
Publications (1)
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| KR20080095879A true KR20080095879A (ko) | 2008-10-29 |
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| KR1020087020096A Withdrawn KR20080095879A (ko) | 2006-02-15 | 2007-02-13 | 신규 아자사이클릴-치환된 아릴티에노피리미디논, 이의 제조 방법 및 이의 약물로서의 용도 |
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| Country | Link |
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| EP (1) | EP1986646A1 (enExample) |
| JP (1) | JP2009526792A (enExample) |
| KR (1) | KR20080095879A (enExample) |
| CN (1) | CN101370501A (enExample) |
| AR (1) | AR059521A1 (enExample) |
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| BR (1) | BRPI0707869A2 (enExample) |
| CA (1) | CA2636605A1 (enExample) |
| IL (1) | IL193341A0 (enExample) |
| TW (1) | TW200800920A (enExample) |
| UY (1) | UY30163A1 (enExample) |
| WO (1) | WO2007093363A1 (enExample) |
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| US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
| RU2486187C2 (ru) | 2007-09-11 | 2013-06-27 | Эбботт Лэборетриз | N-ОКСИДЫ ОКТАГИДРО-ПИРРОЛО[3,4-b]ПИРРОЛА |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| CA2750074A1 (en) | 2009-02-12 | 2010-08-19 | Proyecto De Biomedicina Cima, S.L. | Use of cardiotrophin-1 for the treatment of metabolic diseases |
| WO2010147234A1 (en) * | 2009-06-18 | 2010-12-23 | Banyu Pharmaceutical Co.,Ltd. | Diarylamide-spirodiamine derivative |
| EP3159331A1 (en) | 2010-05-05 | 2017-04-26 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| US8450350B2 (en) | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
| US8933079B2 (en) * | 2012-03-07 | 2015-01-13 | Boehringer Ingelheim International Gmbh | Pyridone and pyridazinone derivatives as anti-obesity agents |
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| GB0124627D0 (en) * | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
| ES2431630T3 (es) * | 2001-11-13 | 2013-11-27 | Emisphere Technologies, Inc. | Compuestos de fenoxiamina y composiciones para administrar principios activos |
| DE10238865A1 (de) * | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| AU2003287880A1 (en) * | 2002-12-11 | 2004-06-30 | 7Tm Pharma A/S | Cyclic quinoline compounds for use in mch receptor related disorders |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| KR20060100412A (ko) * | 2003-10-23 | 2006-09-20 | 글락소 그룹 리미티드 | 비만, 당뇨, 우울증 및 불안증을 치료하기 위한 ｍｃｈｒ１ 길항제로서의 3-(4-아미노페닐)티에노피리미드-4-온유도체 |
| US20050256124A1 (en) * | 2004-04-15 | 2005-11-17 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
-
2007
- 2007-02-13 CA CA002636605A patent/CA2636605A1/en not_active Abandoned
- 2007-02-13 CN CNA2007800029667A patent/CN101370501A/zh active Pending
- 2007-02-13 KR KR1020087020096A patent/KR20080095879A/ko not_active Withdrawn
- 2007-02-13 EP EP07722801A patent/EP1986646A1/en not_active Withdrawn
- 2007-02-13 WO PCT/EP2007/001211 patent/WO2007093363A1/en not_active Ceased
- 2007-02-13 AU AU2007214708A patent/AU2007214708A1/en not_active Abandoned
- 2007-02-13 JP JP2008554652A patent/JP2009526792A/ja active Pending
- 2007-02-13 BR BRPI0707869-2A patent/BRPI0707869A2/pt not_active IP Right Cessation
- 2007-02-13 TW TW096105358A patent/TW200800920A/zh unknown
- 2007-02-15 AR ARP070100660A patent/AR059521A1/es not_active Application Discontinuation
- 2007-02-15 UY UY30163A patent/UY30163A1/es not_active Application Discontinuation
-
2008
- 2008-08-10 IL IL193341A patent/IL193341A0/en unknown
- 2008-08-14 US US12/191,630 patent/US8828991B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2636605A1 (en) | 2007-08-23 |
| UY30163A1 (es) | 2007-09-28 |
| CN101370501A (zh) | 2009-02-18 |
| TW200800920A (en) | 2008-01-01 |
| US8828991B2 (en) | 2014-09-09 |
| BRPI0707869A2 (pt) | 2011-05-10 |
| IL193341A0 (en) | 2009-05-04 |
| US20090082339A1 (en) | 2009-03-26 |
| AU2007214708A1 (en) | 2007-08-23 |
| JP2009526792A (ja) | 2009-07-23 |
| AR059521A1 (es) | 2008-04-09 |
| WO2007093363A1 (en) | 2007-08-23 |
| EP1986646A1 (en) | 2008-11-05 |
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| PA0105 | International application |
Patent event date: 20080814 Patent event code: PA01051R01D Comment text: International Patent Application |
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| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |