KR20080082122A - Ointment composition for regenerating skin - Google Patents

Ointment composition for regenerating skin Download PDF

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KR20080082122A
KR20080082122A KR1020070022518A KR20070022518A KR20080082122A KR 20080082122 A KR20080082122 A KR 20080082122A KR 1020070022518 A KR1020070022518 A KR 1020070022518A KR 20070022518 A KR20070022518 A KR 20070022518A KR 20080082122 A KR20080082122 A KR 20080082122A
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skin
ointment composition
weight
hyaluronic acid
function
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장현숙
김재현
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김재현
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Dermatology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

An ointment composition is provided to show anti-inflammatory function, soothing function and cell regeneration promoting function, provide elasticity and moisturizing property, and prevent allergy, thereby soothing eruption caused by burn, helping skin regeneration, and preventing striae distensae, atopic skin diseases and eczema. An ointment composition comprises 10-15 wt.% of Corydalis incisa, 8-12 wt.% of hyaluronic acid, 4-6 wt.% of sesame oil, 4-6 wt.% of beeswax, 0.5-2 wt.% of Angelicae Gigantis Radix, 0.05-0.2 wt.% of Glycyrrhiza uralensis, 0.05-0.2 wt.% of allantoin and water.

Description

피부재생을 돕는 연고조성물 {Ointment composition for regenerating skin}Ointment composition for skin regeneration {Ointment composition for regenerating skin}

피부는 절창, 자창 등의 직접적인 창상 외에도, 열에 의한 화상, 각종 물리적, 화학적 자극으로 인한 습진, 또는 부신피질호르몬의 증가로 인한 튼살 등 다양한 종류의 손상이 발생할 수 있다. 그 중에서 창상이나 화상으로 인한 손상의 경우 일반적으로 항생제를 함유하는 연고를 이용하여 상처로 인한 세균의 감염을 방지하는 치료가 일차적으로 행해지고 있으나, 상처가 어느 정도 아문 상태이거나, 습진, 튼살로 인한 손상의 경우에는 항생제의 처방이 치료에 실질적으로 도움이 되지 못하므로, 단순히 상처의 치료나 세균 감염을 막는 역할을 하는 치료제와 차별되는, 손상된 피부의 재생을 돕고 습진, 튼살을 방지할 수 있는 연고제가 필요하다.In addition to direct wounds such as cuts and cuts, the skin may cause various types of damage such as heat burns, eczema due to various physical and chemical stimuli, or stretch marks due to an increase in corticosteroids. In the case of injury due to wounds or burns, treatment is generally performed to prevent infection of bacteria due to wounds using an ointment containing antibiotics.However, wounds are damaged to some extent, or due to eczema or stretch marks. In the case of antibiotics, the prescription of antibiotics does not really help, so there is an ointment that can help regenerate damaged skin and prevent eczema and stretch marks, which is different from treatments that simply prevent wound healing or bacterial infection. need.

피부재생을 돕는 연고제와 관련된 종래 기술로서, 대한민국 공개특허 제1990-12624호 습진고, 습진액에서는 백급, 고삼, 지부자, 백반, 물약, 유황, 천산갑의 약재를 혼교합하여 습진고, 습진액을 제조하는 방법을 제공하였고, 공개특허 제1995-26524 피부질환 치료용 의약조성물에서는 송아지의 제단백 혈액추출물 5~20중량%와 아미노글리코사이드계 항생제 0.3~1중량%를 함유하는 화상, 외상, 습진 등의 피부염 치료에 유용한 피부질환 치료용 의약조성물을 제공하였으며, 공개특허 제2001-8260호 피부보호제의 제조방법에서는 꿀 60~80%, 살구씨엑기스 15~20%, 프로폴리스 3~10%, 로얄젤리 2~10%를 함유하는 화상, 기미, 상처, 땀띠, 습진 등의 질환에 유용한 피부보호제를 제공한 바 있다.As a related art related to an ointment to help skin regeneration, in the Republic of Korea Patent Publication No. 1990-12624 Eczema, Eczema solution is prepared by mixing the medicinal herbs such as white, red ginseng, branch, aluminous, potion, sulfur, cheonsan-gap In the pharmaceutical composition for treating skin diseases, burns, trauma, eczema and the like containing 5 to 20% by weight of calf protein extracts and 0.3 to 1% by weight of aminoglycoside antibiotics are provided. Provided was a pharmaceutical composition for the treatment of skin diseases useful for the treatment of dermatitis, in the preparation method of Patent No. 2001-8260 skin protection agent 60-80% honey, apricot seed extract 15-20%, propolis 3-10%, Royal The company has provided skin protectors useful for diseases such as burns, blemishes, wounds, sweats, and eczema, which contain 2-10% of jelly.

본 발명에서는 자근, 히아루론산(Hyaluronic acid), 호마유, 밀랍왁스, 당귀, 감초, 알란토인(Allantoin)을 함유하는 피부재생을 돕는 연고조성물을 제공한다.The present invention provides an ointment composition that helps regenerate the skin containing root, hyaluronic acid (Hyaluronic acid), horse oil, beeswax, Angelica, licorice, Allantoin.

본 발명에서는 항염, 항알레르기, 피부진정, 세포재생 촉진 기능을 하여, 화상으로 인해 손상된 피부의 재생을 돕고 튼살을 방지하며, 습진을 방지하고 아토피성 피부질환을 완화하는 효과를 지닌 연고조성물을 제공하고자 한다.In the present invention, by providing anti-inflammatory, anti-allergic, skin soothing, cell regeneration promoting function, to help the regeneration of damaged skin due to burns, to prevent stretch marks, to prevent eczema and to reduce atopic dermatitis. I would like to.

본 발명은 피부재생을 돕는 연고조성물에 관한 것으로, 자근, 히아루론산(Hyaluronic acid), 호마유, 밀랍왁스, 당귀, 감초, 알란토인(Allantoin)과 물을 함유한다.The present invention relates to an ointment composition that helps skin regeneration, and contains root, hyaluronic acid, horse oil, beeswax, Angelica, licorice, allantoin and water.

자근은 항균작용이 뛰어나 세균의 번식을 막아주므로 한방에서는 피부 외용제로 널리 이용되고 있으며, 특히 화상으로 손상된 피부의 회복을 돕고, 발진, 피부염을 개선하는 효과가 뛰어난 것으로 알려져 있다. 본 발명에서는 건조분말의 형 태로 혼합한다.Root is excellent in antibacterial activity and prevents the growth of bacteria, so it is widely used as a skin external preparation in oriental medicine. Especially, it is known to be effective in helping to recover the skin damaged by burns and improve rash and dermatitis. In the present invention, it is mixed in the form of a dry powder.

히아루론산(Hyaluronic acid)은 N-아세틸글루코사민과 글루쿠론산이 교대로 사슬 모양으로 결합한 분자량이 20만∼40만 되는 고분자 화합물로 뮤코다당류의 일종이다. 히아루론산은 콜라겐, 엘라스틴, 황산콘드로이틴 등 조직을 지탱하는 단백질과 당단백질들의 지지체 역할을 하여, 피부조직을 지탱하고 외부로부터 세균의 침입이나 독물의 침투를 막는 역할을 한다. 또한, 보습능력이 우수하고 주름을 방지하는 효과로 인하여 화장품의 재료로 사용되고 있다.Hyaluronic acid (Hyaluronic acid) is a polymer compound having a molecular weight of 200,000 to 400,000 by alternating N-acetylglucosamine and glucuronic acid in the form of chains, a kind of mucopolysaccharide. Hyaluronic acid serves as a support for proteins and glycoproteins that support tissues such as collagen, elastin, and chondroitin sulfate, and supports skin tissue and prevents invasion of bacteria and invasion of toxins from the outside. In addition, it has been used as a material of cosmetics because of its excellent moisturizing ability and anti-wrinkle effect.

호마유는 볶지 않은 검은참깨로부터 냉압착 방식으로 추출하므로 냄새가 거의 없는 특징이 있으며, 아미노산인 트립토판, 메티오닌과 세사민, 세사몰, 세사몰린 등의 성분을 함유하고 있다. 특히, 비타민 E와 불포화지방산이 매우 풍부하여 산화방지작용이 뛰어나므로 피부의 노화방지 및 수렴작용이 우수하며, 세사몰 성분을 함유하여 자외선을 차단하는 효과가 있다.Houma oil is extracted from unroasted black sesame seeds by cold press method, and has almost no smell, and contains components such as amino acids tryptophan, methionine and sesamin, sesamol, and sesamoline. In particular, it is very rich in vitamin E and unsaturated fatty acids, and therefore excellent in anti-oxidation action, so it is excellent in anti-aging and astringent action of the skin, and contains sesamol component to block ultraviolet rays.

밀랍왁스는 꿀벌집에서 추출한 천연 유화제로 연고의 제형을 유지하는 기능이 있고, 미리사이클릭 알콜(myricyclic alcohol)성분을 함유하여 상처의 치료를 돕는 역할을 한다.Beeswax is a natural emulsifier extracted from the honeycomb and maintains the formulation of the ointment, and contains a myricyclic alcohol component to help heal the wound.

당귀에는 방향유, 비타민, 유기산이 다양하게 함유되어 혈액순환 및 피부재생을 촉진하고, 멜라닌 세포의 형성을 억제하여 미백 기능이 우수하며, 피부의 노화를 방지하고 탄력을 주는 역할을 한다. 또한, 피부의 부기를 가라앉히고 세균의 생장을 억제하는 기능이 있다. 본 발명에서는 건조분말의 형태로 혼합한다.Angelica contains a variety of fragrance oils, vitamins, organic acids to promote blood circulation and skin regeneration, inhibit the formation of melanocytes, excellent whitening function, prevents aging and elasticity of the skin. In addition, it has the function of reducing the swelling of the skin and inhibit the growth of bacteria. In the present invention, the mixture is mixed in the form of a dry powder.

감초는 각종 유기산과 플라보노이드, 사포닌 성분이 다양하게 함유되어 있으 며, 소염작용이 뛰어나 염증을 방지하고 피부를 진정시켜 알레르기를 방지하는 기능이 있다. 또한, 세포의 재생을 촉진하여 상처의 치료를 돕고 각질과 피지를 제거하여 피부를 매끄럽게 하며, 피부노화를 방지하고 여드름이나 아토피 피부를 개선하는 역할을 한다. 본 발명에서는 건조분말의 형태로 혼합한다.Licorice contains a variety of organic acids, flavonoids and saponins, and has anti-inflammatory properties to prevent inflammation and soothe the skin to prevent allergies. In addition, it promotes the regeneration of cells to help heal wounds, remove keratin and sebum to smooth skin, prevent skin aging and improve acne or atopic skin. In the present invention, the mixture is mixed in the form of a dry powder.

알란토인(Allantoin)은 컴프리의 뿌리에 많이 함유되어 있는 물질로, 항염작용이 우수하여 소염제로 이용되고 항알레르기 작용이 우수하여 민감성 피부용 화장품에도 첨가한다. 또한, 세포의 생장을 촉진하므로 손상된 피부의 치료에 효과적이며 여드름, 아토피질환의 치료에도 효과적이다. 본 발명에서는 건조분말의 형태로 혼합한다.Allantoin is a substance contained in the root of Comfrey. It is used as an anti-inflammatory agent because of its excellent anti-inflammatory effect. It is also added to cosmetics for sensitive skin due to its excellent anti-allergic effect. In addition, it promotes the growth of cells, so it is effective in the treatment of damaged skin and in the treatment of acne and atopic diseases. In the present invention, the mixture is mixed in the form of a dry powder.

본 발명의 연고조성물은 자근 10~15중량%, 히아루론산(Hyaluronic acid) 8~12중량%, 호마유 4~6중량%, 밀랍왁스 4~6중량%, 당귀 0.5~2중량%, 감초 0.05~0.2중량%, 알란토인(Allantoin) 0.05~0.2중량%와 물을 함유한다.Ointment composition of the present invention 10 ~ 15% by weight, hyaluronic acid (Hyaluronic acid) 8-12% by weight, horse oil 4-6%, beeswax wax 4-6%, Angelica 0.5-2% by weight, licorice 0.05-0.2 % By weight, 0.05-0.2% by weight Allantoin and water.

본 발명에 있어서 상기 함량이 절대적인 것은 아니나, 각각의 성분의 함량이 적으면 효과가 떨어지는 반면 지나치게 다량 혼합하면 비용이 상승하는 단점이 있고, 밀랍성분의 경우 함량이 적으면 연고의 제형을 이루지 못하고 흘러내리며 함량이 너무 많으면 단단한 질감으로 발림성이 떨어지므로, 상기 성분의 함량범위를 벗어나지 않는 것이 바람직하다.In the present invention, the above content is not absolute, but if the content of each component is low, the effect is reduced while mixing too much, and in the case of beeswax components, if the content is low, the ointment does not form the formulation If the content is too high, the applicability is poor due to the hard texture, it is preferable not to go out of the content range of the component.

[실시예]EXAMPLE

자근 12g, 히아루론산(Hyaluronic acid) 10g, 호마유 5g, 밀랍왁스 5g, 당귀 1g, 감초 0.1g, 알란토인(Allantoin) 0.1g과 물 66.8g을 균일하게 혼합하여 본 발명의 연고조성물을 제조하였다.12 g of root root, hyaluronic acid (10 g), horse oil 5 g, beeswax wax 5 g, Angelica 1 g, licorice 0.1 g, Allantoin (0.1 g) and 66.8 g of water were uniformly mixed to prepare an ointment composition of the present invention.

상기 실시예에 따른 본 발명의 연고조성물은 항염, 항알레르기, 피부진정, 세포재생 촉진 기능이 있으므로, 1일 1~2회 문제가 발생한 부위에 도포함으로써, 화상으로 인해 손상된 피부의 재생을 돕고 튼살을 방지하며, 습진, 아토피성 피부질환을 방지하는 효과를 나타낸다.The ointment composition of the present invention according to the embodiment has anti-inflammatory, anti-allergic, skin soothing, and cell regeneration-promoting functions, so that it is applied to the site where the problem occurs once or twice a day, to help regenerate the damaged skin due to burns and stretch It is effective in preventing eczema and atopic skin diseases.

본 발명의 연고조성물은 항염기능, 진정기능 및 세포재생을 촉진하는 기능을 하므로 화상으로 인한 발진을 진정시키고 피부의 재생을 돕는 역할을 하며, 피부에 탄력성과 보습성을 부여하고 조직재생을 도우므로 튼살을 방지하는 효과가 있다. 또한, 알레르기를 방지하여 아토피성 피부질환이나 습진을 예방하는 효과가 있다.The ointment composition of the present invention functions to promote anti-inflammatory function, sedative function and cell regeneration, so as to soothe rash caused by burns and to help regeneration of the skin, and to give elasticity and moisturizing to the skin and help tissue regeneration. It is effective in preventing stretch marks. In addition, by preventing allergies are effective in preventing atopic dermatitis or eczema.

Claims (2)

자근 10~15중량%, 히아루론산(Hyaluronic acid) 8~12중량%, 호마유 4~6중량%, 밀랍왁스 4~6중량%, 당귀 0.5~2중량%, 감초 0.05~0.2중량%, 알란토인(Allantoin) 0.05~0.2중량%와 물로 이루어진 연고조성물.Root 10-15%, Hyaluronic acid 8-12%, Horsetail oil 4-6%, Beeswax wax 4-6%, Angelica 0.5-2%, Licorice 0.05-0.2%, Allantoin Ointment composition consisting of 0.05 to 0.2% by weight and water. 제1항에 있어서, 자근 12중량%, 히아루론산(Hyaluronic acid) 10중량%, 호마유 5중량%, 밀랍왁스 5중량%, 당귀 1중량%, 감초 0.1중량%, 알란토인(Allantoin) 0.1중량%와 물로 이루어진 연고조성물.The method of claim 1, wherein 12% by weight of root root, 10% by weight of hyaluronic acid, 5% by weight of horse oil, 5% by weight of beeswax, 1% by weight of Angelica, 0.1% by weight of licorice, 0.1% by weight of Allantoin and water Ointment composition.
KR1020070022518A 2007-03-07 2007-03-07 Ointment composition for regenerating skin KR20080082122A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013736A1 (en) * 2010-07-28 2012-02-02 Horus Pharma Preservative-free composition for topical use including hyaluronic acid
KR102425235B1 (en) * 2021-11-30 2022-07-27 더라이프비 주식회사 Composition for preventing or improving stretch marks comprising complex extract and fructan as active ingredient
KR102448016B1 (en) * 2021-11-30 2022-09-28 더라이프비 주식회사 Composition for preventing or improving stretch marks comprising complex extract as active ingredient

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013736A1 (en) * 2010-07-28 2012-02-02 Horus Pharma Preservative-free composition for topical use including hyaluronic acid
FR2963240A1 (en) * 2010-07-28 2012-02-03 Horus Pharma COMPOSITION FOR TOPICAL USE WITHOUT PRESERVATIVE COMPRISING HYALURONIC ACID
KR102425235B1 (en) * 2021-11-30 2022-07-27 더라이프비 주식회사 Composition for preventing or improving stretch marks comprising complex extract and fructan as active ingredient
KR102448016B1 (en) * 2021-11-30 2022-09-28 더라이프비 주식회사 Composition for preventing or improving stretch marks comprising complex extract as active ingredient

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