KR20080059297A - 전압-개폐 나트륨 채널의 조절제로서의 ４급알파-아미노카르복스아미드 유도체 - Google Patents
전압-개폐 나트륨 채널의 조절제로서의 ４급알파-아미노카르복스아미드 유도체 Download PDFInfo
- Publication number
- KR20080059297A KR20080059297A KR1020087011273A KR20087011273A KR20080059297A KR 20080059297 A KR20080059297 A KR 20080059297A KR 1020087011273 A KR1020087011273 A KR 1020087011273A KR 20087011273 A KR20087011273 A KR 20087011273A KR 20080059297 A KR20080059297 A KR 20080059297A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- phenyl
- oxy
- fluorophenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000016913 Voltage-Gated Sodium Channels Human genes 0.000 title claims abstract description 26
- 108010053752 Voltage-Gated Sodium Channels Proteins 0.000 title claims abstract description 26
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 95
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- 238000011282 treatment Methods 0.000 claims abstract description 33
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- -1 4-{[(2-fluorophenyl) methyl] oxy} phenyl Chemical group 0.000 claims description 114
- 238000000034 method Methods 0.000 claims description 85
- 239000002904 solvent Substances 0.000 claims description 79
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 77
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 67
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 35
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- 229940002612 prodrug Drugs 0.000 claims description 28
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
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- FDIJVQHOCKBDLC-TZIWHRDSSA-N (2r,5r)-2-[3-[(2-fluorophenyl)methoxy]phenyl]-7-methyl-1,7-diazaspiro[4.4]nonan-6-one Chemical compound O=C1N(C)CC[C@@]11N[C@@H](C=2C=C(OCC=3C(=CC=CC=3)F)C=CC=2)CC1 FDIJVQHOCKBDLC-TZIWHRDSSA-N 0.000 claims description 4
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- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
- AJYGGNUGQMYSRP-FPOVZHCZSA-N (2s,5s)-2-[4-[(2-fluorophenyl)methoxy]phenyl]-1,9-diazaspiro[4.5]decan-10-one Chemical compound FC1=CC=CC=C1COC1=CC=C([C@H]2N[C@]3(C(NCCC3)=O)CC2)C=C1 AJYGGNUGQMYSRP-FPOVZHCZSA-N 0.000 claims description 3
- SMPXCHFZGCEVTB-FPOVZHCZSA-N (5s,7s)-7-[4-[(2-fluorophenyl)methoxy]phenyl]-2,6-diazaspiro[4.5]decan-1-one Chemical compound FC1=CC=CC=C1COC1=CC=C([C@H]2N[C@@]3(C(NCC3)=O)CCC2)C=C1 SMPXCHFZGCEVTB-FPOVZHCZSA-N 0.000 claims description 3
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Classifications
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0520578.6 | 2005-10-10 | ||
| GB0520578A GB0520578D0 (en) | 2005-10-10 | 2005-10-10 | Novel compounds |
| GB0523030A GB0523030D0 (en) | 2005-11-11 | 2005-11-11 | Novel compounds |
| GB0523030.5 | 2005-11-11 | ||
| GB0603897A GB0603897D0 (en) | 2006-02-27 | 2006-02-27 | Novel compounds |
| GB0603897.0 | 2006-02-27 | ||
| GB0609159.9 | 2006-05-09 | ||
| GB0609159A GB0609159D0 (en) | 2006-05-09 | 2006-05-09 | Novel Compounds |
| GB0618511A GB0618511D0 (en) | 2006-09-20 | 2006-09-20 | Novel compounds |
| GB0618511.0 | 2006-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080059297A true KR20080059297A (ko) | 2008-06-26 |
Family
ID=37762326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087011273A Withdrawn KR20080059297A (ko) | 2005-10-10 | 2006-10-06 | 전압-개폐 나트륨 채널의 조절제로서의 ４급알파-아미노카르복스아미드 유도체 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US7803833B2 (https=) |
| EP (1) | EP1934176B1 (https=) |
| JP (1) | JP5139306B2 (https=) |
| KR (1) | KR20080059297A (https=) |
| AR (1) | AR057869A1 (https=) |
| AT (1) | ATE543797T1 (https=) |
| AU (1) | AU2006301471A1 (https=) |
| BR (1) | BRPI0617189A2 (https=) |
| CA (1) | CA2625763A1 (https=) |
| CR (1) | CR9926A (https=) |
| EA (1) | EA200801068A1 (https=) |
| ES (1) | ES2381686T3 (https=) |
| IL (1) | IL190544A (https=) |
| NO (1) | NO20082122L (https=) |
| NZ (1) | NZ567030A (https=) |
| PE (1) | PE20070495A1 (https=) |
| TW (1) | TW200728258A (https=) |
| WO (1) | WO2007042240A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200730494A (en) * | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
| EP1943216B1 (en) * | 2005-10-10 | 2010-06-30 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
| GB0701365D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0701366D0 (en) * | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) * | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
| DK2477964T5 (en) * | 2009-09-14 | 2015-05-26 | Convergence Pharmaceuticals | A process for the preparation of alpha-carboxamide |
| JP2011232320A (ja) * | 2009-10-01 | 2011-11-17 | Sony Corp | 生体内物質検出用プローブ、および該生体内物質検出用プローブを用いた生体内物質検出装置 |
| CA2828456C (en) | 2011-03-03 | 2021-05-04 | Zalicus Pharmaceuticals Ltd. | N-benzl-amino-carboxamide inhibitors of the sodium channel |
| GB201122113D0 (en) | 2011-12-22 | 2012-02-01 | Convergence Pharmaceuticals | Novel compounds |
| GB201209015D0 (en) | 2012-05-22 | 2012-07-04 | Convergence Pharmaceuticals | Novel compounds |
| GB201209670D0 (en) * | 2012-05-31 | 2012-07-18 | Convergence Pharmaceuticals | Novel compounds |
| ES2912881T3 (es) * | 2014-12-23 | 2022-05-30 | Convergence Pharmaceuticals | Procedimiento para preparar derivados de alfa-carboxamida pirrolidina |
| WO2016160574A2 (en) * | 2015-03-27 | 2016-10-06 | Scifluor Life Sciences, Inc. | Aryl- and heteroaryl-pyrrolidine-2-carboxamide compounds |
| US11192856B2 (en) | 2017-10-05 | 2021-12-07 | Biogen Inc. | Process for preparing alpha-carboxamide pyrrolidine derivatives |
| US11149039B2 (en) | 2017-10-10 | 2021-10-19 | Biogen Inc. | Process for preparing spiro derivatives |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94466A (en) | 1989-05-25 | 1995-01-24 | Erba Carlo Spa | Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation |
| US6201016B1 (en) | 1994-06-27 | 2001-03-13 | Cytomed Incorporated | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| TW502019B (en) | 1999-03-26 | 2002-09-11 | Cocensys Inc | Aryl substituted pyrazoles, imidazoles, oxazoles, thiazoles and pyrroles, and the use thereof |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| TW200404796A (en) * | 2002-08-19 | 2004-04-01 | Ono Pharmaceutical Co | Nitrogen-containing compound |
| PE20050077A1 (es) | 2002-09-20 | 2005-03-01 | Hoffmann La Roche | Derivados de 4-pirrolidino-fenil-bencil-eter |
| MY142651A (en) | 2003-03-18 | 2010-12-15 | Merck Sharp & Dohme | Biaryl substituted triazoles as sodium channel blockers |
| US7589116B2 (en) | 2003-04-03 | 2009-09-15 | Merck & Co. Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| CA2522476A1 (en) | 2003-04-18 | 2004-11-04 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| WO2005000309A2 (en) | 2003-06-27 | 2005-01-06 | Ionix Pharmaceuticals Limited | Chemical compounds |
| US20060217365A1 (en) * | 2003-07-02 | 2006-09-28 | Astrazeneca Ab | Method of treating mood disorders |
| EP1524265A1 (en) | 2003-10-15 | 2005-04-20 | Newron Pharmaceuticals S.p.A. | Prolinamide derivatives as sodium and/or calcium channel blockers or selective MAO-B inhibitors |
| WO2006119390A1 (en) | 2005-05-04 | 2006-11-09 | Vertex Pharmaceuticals Incorporated | Pyridines useful as modulators of ion channels |
| JP2008540443A (ja) | 2005-05-04 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なピリミジンおよびピラジン |
| JP2008540665A (ja) | 2005-05-19 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネルのモジュレーターとして有用なビアリール |
| GB0701366D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| GB0701365D0 (en) | 2007-01-24 | 2007-03-07 | Glaxo Group Ltd | Novel pharmaceutical compositions |
| GB0706630D0 (en) | 2007-04-04 | 2007-05-16 | Glaxo Group Ltd | Novel compounds |
-
2006
- 2006-10-05 TW TW095136996A patent/TW200728258A/zh unknown
- 2006-10-06 US US11/570,564 patent/US7803833B2/en active Active
- 2006-10-06 EP EP06806111A patent/EP1934176B1/en active Active
- 2006-10-06 BR BRPI0617189-3A patent/BRPI0617189A2/pt not_active IP Right Cessation
- 2006-10-06 KR KR1020087011273A patent/KR20080059297A/ko not_active Withdrawn
- 2006-10-06 EA EA200801068A patent/EA200801068A1/ru unknown
- 2006-10-06 JP JP2008534911A patent/JP5139306B2/ja not_active Expired - Fee Related
- 2006-10-06 AU AU2006301471A patent/AU2006301471A1/en not_active Abandoned
- 2006-10-06 AT AT06806111T patent/ATE543797T1/de active
- 2006-10-06 ES ES06806111T patent/ES2381686T3/es active Active
- 2006-10-06 WO PCT/EP2006/009732 patent/WO2007042240A1/en not_active Ceased
- 2006-10-06 CA CA002625763A patent/CA2625763A1/en not_active Abandoned
- 2006-10-06 PE PE2006001224A patent/PE20070495A1/es not_active Application Discontinuation
- 2006-10-06 NZ NZ567030A patent/NZ567030A/en unknown
- 2006-10-09 AR ARP060104440A patent/AR057869A1/es active IP Right Grant
-
2008
- 2008-03-31 IL IL190544A patent/IL190544A/en active IP Right Grant
- 2008-04-25 CR CR9926A patent/CR9926A/es not_active Application Discontinuation
- 2008-05-06 NO NO20082122A patent/NO20082122L/no not_active Application Discontinuation
-
2010
- 2010-08-04 US US12/850,330 patent/US8153623B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0617189A2 (pt) | 2011-07-19 |
| CR9926A (es) | 2008-07-29 |
| TW200728258A (en) | 2007-08-01 |
| EA200801068A1 (ru) | 2009-02-27 |
| US8153623B2 (en) | 2012-04-10 |
| ES2381686T3 (es) | 2012-05-30 |
| US20080293753A1 (en) | 2008-11-27 |
| PE20070495A1 (es) | 2007-05-17 |
| IL190544A0 (en) | 2008-11-03 |
| US20100324022A1 (en) | 2010-12-23 |
| JP5139306B2 (ja) | 2013-02-06 |
| CA2625763A1 (en) | 2007-04-19 |
| EP1934176A1 (en) | 2008-06-25 |
| AU2006301471A1 (en) | 2007-04-19 |
| US7803833B2 (en) | 2010-09-28 |
| JP2009514801A (ja) | 2009-04-09 |
| NO20082122L (no) | 2008-07-02 |
| AR057869A1 (es) | 2007-12-26 |
| ATE543797T1 (de) | 2012-02-15 |
| WO2007042240A1 (en) | 2007-04-19 |
| NZ567030A (en) | 2011-03-31 |
| EP1934176B1 (en) | 2012-02-01 |
| IL190544A (en) | 2013-06-27 |
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Patent event date: 20080509 Patent event code: PA01051R01D Comment text: International Patent Application |
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| PC1203 | Withdrawal of no request for examination | ||
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