KR20070118100A - 암 화학요법제로서 유용한 1,3-티아졸-5-카르복사미드 - Google Patents
암 화학요법제로서 유용한 1,3-티아졸-5-카르복사미드 Download PDFInfo
- Publication number
- KR20070118100A KR20070118100A KR1020077022535A KR20077022535A KR20070118100A KR 20070118100 A KR20070118100 A KR 20070118100A KR 1020077022535 A KR1020077022535 A KR 1020077022535A KR 20077022535 A KR20077022535 A KR 20077022535A KR 20070118100 A KR20070118100 A KR 20070118100A
- Authority
- KR
- South Korea
- Prior art keywords
- alkoxy
- substituted
- alkyl
- group
- amino
- Prior art date
Links
- 0 CCOC(c1cc(C(*)=O)ncc1)=O Chemical compound CCOC(c1cc(C(*)=O)ncc1)=O 0.000 description 4
- IVBMYNIGRSWQHK-UHFFFAOYSA-N CC(C(Nc1cc(CCl)ccn1)=O)OC Chemical compound CC(C(Nc1cc(CCl)ccn1)=O)OC IVBMYNIGRSWQHK-UHFFFAOYSA-N 0.000 description 1
- YWGZRNXPDONHEM-UHFFFAOYSA-N CC(C)(C(Cl)=O)OC Chemical compound CC(C)(C(Cl)=O)OC YWGZRNXPDONHEM-UHFFFAOYSA-N 0.000 description 1
- MCRPKBUFXAKDKI-UHFFFAOYSA-N CCOC(c1ccncc1)=O Chemical compound CCOC(c1ccncc1)=O MCRPKBUFXAKDKI-UHFFFAOYSA-N 0.000 description 1
- APLFJNPDEYCQSY-UHFFFAOYSA-N CN(CC1)CCN1C(NC1=CC(CNc2c(C(Nc(cc3)cc(OC4(F)F)c3OC4(F)F)=O)[s]cn2)=CCN1C)=O Chemical compound CN(CC1)CCN1C(NC1=CC(CNc2c(C(Nc(cc3)cc(OC4(F)F)c3OC4(F)F)=O)[s]cn2)=CCN1C)=O APLFJNPDEYCQSY-UHFFFAOYSA-N 0.000 description 1
- DZJAJZJHVUBELV-UHFFFAOYSA-N CNC(Nc1cc(CCl)ccn1)=O Chemical compound CNC(Nc1cc(CCl)ccn1)=O DZJAJZJHVUBELV-UHFFFAOYSA-N 0.000 description 1
- ADDFSWRAELYAEK-UHFFFAOYSA-N COCCOCC(Nc1cc(CNc2c(C(Nc(cc3OC4(F)F)ccc3OC4(F)F)=O)[s]cn2)ccn1)O Chemical compound COCCOCC(Nc1cc(CNc2c(C(Nc(cc3OC4(F)F)ccc3OC4(F)F)=O)[s]cn2)ccn1)O ADDFSWRAELYAEK-UHFFFAOYSA-N 0.000 description 1
- ZBGBSPWRJGSDLZ-UHFFFAOYSA-N CS(OCc1ccnc(C(N)=O)c1)(=O)=O Chemical compound CS(OCc1ccnc(C(N)=O)c1)(=O)=O ZBGBSPWRJGSDLZ-UHFFFAOYSA-N 0.000 description 1
- SNEIGCJVCZVMKA-UHFFFAOYSA-N NC(c1cc(CO)ccn1)=O Chemical compound NC(c1cc(CO)ccn1)=O SNEIGCJVCZVMKA-UHFFFAOYSA-N 0.000 description 1
- WHENGHYSESZAMT-UHFFFAOYSA-N O=C(c1c(NCc2ccnc(NC(NCC3OCCC3)=O)c2)nc[s]1)Nc(cc1O2)ccc1OC2(F)F Chemical compound O=C(c1c(NCc2ccnc(NC(NCC3OCCC3)=O)c2)nc[s]1)Nc(cc1O2)ccc1OC2(F)F WHENGHYSESZAMT-UHFFFAOYSA-N 0.000 description 1
- QJTSKLLBMGPQNP-UHFFFAOYSA-N O=C(c1c(NCc2nc(Cl)nc(Cl)c2)nc[s]1)Nc(cc1)cc(O2)c1OC2(F)F Chemical compound O=C(c1c(NCc2nc(Cl)nc(Cl)c2)nc[s]1)Nc(cc1)cc(O2)c1OC2(F)F QJTSKLLBMGPQNP-UHFFFAOYSA-N 0.000 description 1
- IEIJATXKWNLABI-UHFFFAOYSA-N O=C(c1ccccc1)NC(Nc1nccc(CCl)c1)=O Chemical compound O=C(c1ccccc1)NC(Nc1nccc(CCl)c1)=O IEIJATXKWNLABI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65898505P | 2005-03-04 | 2005-03-04 | |
| US60/658,985 | 2005-03-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20070118100A true KR20070118100A (ko) | 2007-12-13 |
Family
ID=36676308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077022535A KR20070118100A (ko) | 2005-03-04 | 2006-02-24 | 암 화학요법제로서 유용한 1,3-티아졸-5-카르복사미드 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090023753A1 (pt) |
| EP (1) | EP1858893A1 (pt) |
| JP (1) | JP2008531688A (pt) |
| KR (1) | KR20070118100A (pt) |
| CN (1) | CN101133054A (pt) |
| AU (1) | AU2006221037A1 (pt) |
| BR (1) | BRPI0609147A2 (pt) |
| CA (1) | CA2600039A1 (pt) |
| CR (1) | CR9340A (pt) |
| EA (1) | EA200701881A1 (pt) |
| IL (1) | IL185518A0 (pt) |
| MA (1) | MA29671B1 (pt) |
| MX (1) | MX2007010099A (pt) |
| TN (1) | TNSN07300A1 (pt) |
| WO (1) | WO2006096338A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101932587A (zh) | 2007-09-24 | 2010-12-29 | 吉宁特有限公司 | 噻唑并嘧啶pi3k抑制剂化合物及使用方法 |
| KR101051078B1 (ko) | 2008-12-05 | 2011-07-21 | 한국화학연구원 | 염증관련 질환치료제용 2,4-이중치환-5-아미노카르보닐-1,3-티아졸 유도체, 그의 제조방법 및 그를 유효성분으로 함유하는 ｓｐｃ 수용체 활성으로 유발되는 염증관련질환 치료제 |
| US20130165450A1 (en) * | 2010-09-14 | 2013-06-27 | Hon-Chung Tsui | Novel Thiazol-Carboximide Derivatives as PDK1 Inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| TWI299664B (en) * | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
| DE102004039876A1 (de) * | 2004-06-23 | 2006-01-26 | Lanxess Deutschland Gmbh | Herstellung von fluorierten 1,3-Benzodioxanen |
-
2006
- 2006-02-24 CA CA002600039A patent/CA2600039A1/en not_active Abandoned
- 2006-02-24 AU AU2006221037A patent/AU2006221037A1/en not_active Abandoned
- 2006-02-24 US US11/885,104 patent/US20090023753A1/en not_active Abandoned
- 2006-02-24 BR BRPI0609147-4A patent/BRPI0609147A2/pt not_active Application Discontinuation
- 2006-02-24 WO PCT/US2006/006436 patent/WO2006096338A1/en active Application Filing
- 2006-02-24 JP JP2007558072A patent/JP2008531688A/ja active Pending
- 2006-02-24 KR KR1020077022535A patent/KR20070118100A/ko not_active Application Discontinuation
- 2006-02-24 CN CNA2006800070845A patent/CN101133054A/zh active Pending
- 2006-02-24 EA EA200701881A patent/EA200701881A1/ru unknown
- 2006-02-24 EP EP06721003A patent/EP1858893A1/en not_active Withdrawn
- 2006-02-24 MX MX2007010099A patent/MX2007010099A/es unknown
-
2007
- 2007-07-31 TN TNP2007000300A patent/TNSN07300A1/en unknown
- 2007-08-27 IL IL185518A patent/IL185518A0/en unknown
- 2007-08-27 CR CR9340A patent/CR9340A/es not_active Application Discontinuation
- 2007-10-02 MA MA30269A patent/MA29671B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA29671B1 (fr) | 2008-08-01 |
| WO2006096338A1 (en) | 2006-09-14 |
| CR9340A (es) | 2010-04-05 |
| BRPI0609147A2 (pt) | 2010-02-17 |
| AU2006221037A1 (en) | 2006-09-14 |
| TNSN07300A1 (en) | 2008-12-31 |
| US20090023753A1 (en) | 2009-01-22 |
| CN101133054A (zh) | 2008-02-27 |
| JP2008531688A (ja) | 2008-08-14 |
| IL185518A0 (en) | 2008-01-06 |
| EP1858893A1 (en) | 2007-11-28 |
| MX2007010099A (es) | 2007-10-12 |
| CA2600039A1 (en) | 2006-09-14 |
| EA200701881A1 (ru) | 2008-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |