KR20070020421A - Treatment of keratinous tissue - Google Patents

Abstract

A method of treating keratinous tissue is disclosed. This treatment utilizes a receptacle having at least one topical composition for application to keratinous tissue, a vesicle comprising the topical composition and a heating system for releasably receiving the at least one vesicle.

Keratinous tissue, receptacles, power, topical compositions, vesicles, skin care

Description

Treatment of keratinous tissue {TREATMENT OF KERATINOUS TISSUE}

The present invention relates to a method of treating keratinous tissue. This treatment utilizes a receptacle having at least one topical composition for application to keratinous tissue, a sachet comprising the topical composition and a heating system to releasably receive at least one vesicle.

Many topical application products currently available to the consumer are primarily intended to improve the health and / or physical appearance of the skin. Many of these skin care products are typically intended to delay, minimize or even eliminate skin wrinkles, skin discoloration and other biotissue changes associated with aging and / or environmental damage to human skin. Other topically applied products include drugs designed to treat certain diseases through keratinous tissue.

Consumers prefer topical products because these products are not only effective but also pleasant and safe to use. The experience of topical application is enhanced when the topical application is warmed or heated. For example, when a warm moisturizing lotion is applied to the face or skin of the body, users perceive a more pleasant feeling than application of a cold lotion. The experience of applying the lotion is then a motivating factor in the use of the lotion, and the lotion is applied more frequently than when coldly applied. Regular use of topical products ensures the achievement of the maximum effect of the active agent.

Many topical compositions reduce viscosity when warmed. The reduced viscosity allows the composition to flow more easily onto the skin, hair or nails. Vaseline is an example of such a product. When warmed, petroleum jelly becomes less viscous and the user can apply a thinner coat with less force. When petroleum jelly is cooled, petroleum jelly reverts to its original rheology, leaving a thin but complete coat on the petroleum jelly-coated surface.

Of course, the topical composition may become so thin that it is not aesthetically pleasing, more difficult to apply, and may quickly contaminate the surrounding area when spilled. For this reason, it is important that the temperature at which the topical composition is heated is within a controlled range. This controlled range depends on the particular composition being heated.

It is known to warm or heat topical application products through the delivery of a fluid product from a reservoir. Many topically applied products, however, are easily degraded by heat, in particular by repeated heating. In addition, the time required to heat all of the products in a large reservoir is considerable. Today lotion users are often limited in terms of time allocated to personal care, and the warming step may be skipped when the user is busy.

Warmer-holders for filling packets of fluids are known in the art. Such heater-holders include a heater assembly, which is powered by an electrical plug-pin that fits into a power socket outlet.

Based on the foregoing, there is a continuing need to provide topical compositions in a form that is quickly prepared, easy to use and that provides a pleasant warmth.

Summary of the Invention

In the present application, a method of treating keratinous tissue is disclosed. The method includes, as a first step, warming a topical composition contained in a vesicle using a receptacle. The receptacle may comprise a wall forming a cavity for releasably receiving one or more vesicles; A heating system connected with one or more walls of the cavity; And a power source operatively connected with the heating system. The power source warms the composition inside the vesicles to a target temperature that is sufficient to supply sufficient energy to the heating system to facilitate application to keratinous tissue but is not fluid enough to flow from the surface when applied. Typically this temperature is about 30 ° C To 65 ° C. The warmed composition is removed from the vesicles and applied to the keratinous tissue.

In addition, the present application discloses a receptacle for warming a topical composition contained within a vesicle. The receptacle may comprise a wall defining a cavity for releasably receiving one or more vesicles; And a heating system connected with the one or more cavity walls. The heating system achieves and maintains the target temperature of the topical composition. In one embodiment the heating system is operated by insertion of the vesicles. In another embodiment, the receptacle is controlled by a monitor such that the heating system maintains this target temperature for a period of time when a topical composition target temperature suitable for application of the topical composition is achieved. Finally, the receptacle includes a power source operatively connected with the heating system to supply energy to the heating system.

Also disclosed are kits for treating keratinous tissue. The kit includes one or more topical compositions, one or more vesicles comprising a surface forming one or more chambers for containing the composition, and a receptacle for releasably receiving one or more vesicles. The receptacle may comprise a wall defining a cavity for releasably receiving the follicle (s), a heating system connected with one or more walls; And a power source operatively connected with the heating system. The composition is warmed when the vesicles are inserted into the cavity of the receptacle.

Also disclosed herein is selecting a vesicle from a variety of vesicles, inserting the vesicles into a receptacle to releasably receive the vesicles as described above, and operating a heating system operably connected to the receptacle. To warm the composition contained in the vesicles. After warming up, the vesicles are opened and the warmed composition is applied to the user's skin. Optionally, but preferably this regimen is followed at least once daily.

1A is a perspective view of an embodiment of a receptacle into which a vesicle is inserted.

1B is a right side view of the embodiment of FIG. 1A with no vesicles inserted;

1C is a plan view of the embodiment of FIG. 1A.

1D is an exploded view of the embodiment of FIG. 1A with no vesicles inserted;

2A is a front view of a second embodiment of a battery powered receptacle.

2B is a right side view of the embodiment of FIG. 2A.

2C is a cross-sectional view of the embodiment of FIG. 2A taken along line A-A.

2D is a plan view of the embodiment of FIG. 2A.

2E is a back view of the embodiment of FIG. 2A.

3A is a perspective view of a third embodiment of a receptacle designed to receive a plurality of vesicles.

3B is a plan view of the embodiment shown in FIG. 3A.

4A is a perspective view of a fourth embodiment of a receptacle inserted into a docking station.

4B is a top view of the receptacle with the docking station shown in FIG. 4A.

4C is a cross-sectional view of the receptacle with the docking station shown in FIG. 4A taken along line A-A in FIG. 4B.

4D is a left side elevation view of the receptacle with the docking station shown in FIG. 4A.

4E is a front view of the receptacle with the docking station shown in FIG. 4A.

5A is a front view of a first embodiment of a vesicle;

5B is a perspective view of the vesicle shown in FIG. 5A.

5C is a bottom view of the vesicle shown in FIG. 5A.

5D is a right side view of the vesicle shown in FIG. 5A.

5E is a cross-sectional view of the vesicle shown in FIG. 5A taken along line A-A in FIG. 5B.

6A is a front view of a second embodiment of a vesicle having two chambers.

FIG. 6B is a cross-sectional view of the vesicle shown in FIG. 6A taken along line A-A showing the composition involved.

7A is a front view of a third embodiment of a vesicle which also has two chambers.

FIG. 7B is a left side view of the embodiment of FIG. 7A; FIG.

FIG. 7C is a perspective view of the embodiment shown in FIG. 7A. FIG.

8A is a front view of a fourth embodiment of a vesicle having a contact point for operating a heater system.

8B is a side view of the vesicle of FIG. 8A.

8C is a perspective view of the vesicle of FIG. 8A.

9A is a perspective view of a fourth embodiment of a receptacle having two heating elements and two heat sinks.

9B is a front view of the embodiment of FIG. 9A.

9C is a cross-sectional view of the embodiment of FIG. 9A taken along line B-B in FIG. 9B.

Unless otherwise specified, all percentages and ratios used herein are based on the weight of the total composition and all measurements are made at 25 ° C.

The compositions of the present invention may comprise, consist essentially of, or consist of optional ingredients as well as optional ingredients described herein. As used herein, "consisting essentially of" a composition or component may include additional components, but only if these additional components do not substantially alter the basic and novel properties of the claimed composition or method. Means.

As used herein, the term "keratin tissue" refers to a keratin-containing layer disposed as the outermost protective sheath of a mammal, including but not limited to skin, hair, toenails, nails, epidermis, hooves, lips, and the like. Say

As used herein, the term "topical application" means the application or application of a composition of the invention on the surface of keratinous tissue.

As used herein, the term "dermatologically acceptable" means that the compositions or ingredients described are suitable for use in contact with mammalian keratinous tissue without excessive toxicity, incompatibility, instability, allergic reactions, etc. it means.

As used herein, the term "flexible" means "easy to be folded, stretched, deformed or bent by hand or finger".

As used herein, the term "rigid" means "not easily folded, unfolded, deformed or bent by hands or fingers."

As used herein, the term “heating system” refers to all components used to transfer energy from an energy source to the contents of the vesicles or to indicate when a target temperature has been achieved. Examples are heating elements and various other components connected to common walls adjacent to the power source.

As used herein, the term "monitor" means a device that controls all the functions of the heating system.

As used herein, the term "microprocessor" refers to a computer in which an entire central processing unit (CPU) is included on one integrated chip or a plurality of integrated circuit chips. .

As used herein, the term "microcontroller" refers to a microprocessor on a single integrated circuit that is intended to operate as an embedded system. In addition to the CPU, the microcontroller typically includes a small amount of RAM and PROM, a timer, and input / output.

As used herein, the term "heat sink" refers to a piece of thermally conductive material designed to absorb, distribute, or transfer heat from a heat source.

As used herein, the term "sachet" refers to a packet or pouch having a fluid impermeable wall that can be filled with a topical composition or a composition containing a component.

As used herein, the term "unit dose" means an amount of the composition sufficient for a single application or treatment.

As used herein, the term "safe and effective amount" refers to a positive effect, preferably a positive keratinous tissue appearance or tactile effect, including the effects disclosed herein, independently or in combination. It is meant an amount of a compound or composition that is sufficient to induce, but low enough to avoid serious side effects (ie, provides a rational effect to risk ratio within the scope of reasonable judgment of the skilled person).

As used herein, the term "timer" refers to a clock that measures the time interval and marks the end. The timer may also act as a regulator to start / activate or stop / deactivate a mechanism or process at a set time.

As used herein, the term “projection” means a protrusion, ie, a portion that protrudes from the body of an object, such as a vesicle.

As used herein, the term "contact point" refers to any part of the vesicle that operates the heating system by communication with a switch.

As used herein, the term "operably linked" means that they are joined or linked together to produce the appropriate effect.

Topical composition

Compositions for use in the present invention are applied topically. The disclosed topical compositions are useful for the control of keratinous tissue. Due to conditions that can be caused or caused by internal and / or external factors to the body, control of keratinous tissue, in particular human skin, is often required. For example, "skin control" includes prophylactically and / or therapeutically controlling skin conditions and may involve one or more of the following effects: increasing skin thickness (ie, Epidermal and / or dermal layers of the skin and / or subcutaneous layers such as fats and muscles and, where applicable, the stratum corneum of the nails and hair shafts), such as atrophy (e.g. of the skin), an increase in wrinkles of the dermis-epidermal border, Non-melanin skin discoloration, such as dark circles under the eyes, spots (e.g., uneven red coloration due to red nose) (hereinafter referred to as "red spots"), paleness (pale or yellowish color), capillary dilator or spider Discoloration caused by blood vessels, discoloration due to melanin (eg pigmented spots, blotch, uneven pigmentation, hyperpigmentation, eg hyperpigmentation after inflammation) and other chromophores of the skin (eg Lipofu , Thereby reducing the color change caused by the protein cross-linking, such as those generated by a glycosylated etc.). As used herein, prophylactic control of the skin condition is a visible and / or tactile discontinuity of the skin (eg skin texture irregularities, fine lines, wrinkles that can be detected by touch or by touch). , Sagging, stretch marks, cellulite, swollen eyes, etc.). As used herein, therapeutic control of a skin condition includes improving (eg, reducing, minimizing and / or eliminating) discontinuities in the skin. Modulation of skin conditions involves improving skin appearance and / or feel. As used herein, "modulation of skin condition" is intended to include the control of such signs regardless of the mechanism of cause.

A wide range of compositions of the present invention can be used to provide the appearance and / or tactile effects of skin, hair or nails. The amount of the composition of the present invention that is typically applied per application is in units of milligrams of composition over one square centimeter of skin, referred to herein as "mg / cm 2", which is about 0.1 mg / cm 2 to about 20 mg / cm 2 . Particularly useful application amounts are from about 0.5 mg / cm 2 to about 10 mg / cm 2.

Active agent

Embodiments of the invention include compositions containing one or more active ingredients. The active ingredient may be a skin care active. Among the active ingredients that can be selected are those listed below. Mixtures of those listed may also be used. The composition may optionally contain a safe and effective amount of the active agent. Examples of active agents which may be contained are listed below. Such active agents are preferably present in about 0.0001% to about 20%, more preferably from about 0.05% to about 5%, even more preferably from about 0.1% to about 2% by weight of the composition. Exceptions to this preferred range are for the peptides and conditioning agents specified below.

Active agents can have more than one mechanism of action, so placing them in a particular category does not necessarily cover the entire range of activity. Non-limiting examples of active agents useful in the present invention include the following:

Active agent

1. Peeling Activator

-하이드록시산(예를 들어, 글리콜산, 락트산) 및

-케토산(예를 들어, 피루브산)이 있다.An example of a peeling activator is salicylic acid. Another example is

Hydroxy acids (eg glycolic acid, lactic acid) and

Keto acid (eg pyruvic acid).

2. Anti acne actives

Examples of useful anti-acne actives include resorcinol, sulfur, erythromycin, zinc and dehydroacetic acid. Further examples of suitable anti acne agents are described in more detail in US Pat. No. 5,607,980.

3. Anti-wrinkle activator / Atrophy activator

Examples of anti-wrinkle / anti-atrophy active agents suitable for use in the compositions of the present invention include hydroxy acids (eg salicylic acid, glycolic acid), keto acids (eg pyruvic acid), ascorbic acid (vitamin C), pit Acids, lysophosphatidic acids, flavonoids (e.g., isoflavones, flavones, etc.), stilbenes, cinnamates, resveratrol, kinetin, zeatin, dimethylaminoethanol, synthetic peptides, peptides from natural sources (e.g. Soy peptides, salts of sugar acids (eg Mn gluconate), retinoids (eg retinyl propionate), vitamin B compounds (eg thiamine (vitamin B1), niacinamide ( Vitamin B3), panthenol and pantothenic acid (vitamin B5), pyridoxine (vitamin B6), carnitine (vitamin Bt), riboflavin (vitamin B2), and derivatives and salts thereof (e.g., HCl or calcium salts) .

4. Antioxidant / Radical Scavenger

Non-limiting examples of antioxidants / radical scavengers useful in the present invention include ascorbic acid (vitamin C) and salts thereof, ascorbyl esters of fatty acids, ascorbic acid derivatives (e.g. magnesium ascorbyl phosphate), tocopherol (vitamin) E), tocopherol sorbate, tocopherol acetate, other esters of tocopherol, butylated hydroxy benzoic acid and salts thereof (e.g. butylated hydroxyl toluene, commonly known as BHT), 6-hydroxy-2,5,7 , 8-tetramethylchroman-2-carboxylic acid, amine (eg, N, N-diethylhydroxylamine, amino-guanidine), nordihydroguaiaretic acid, bioflavonoids, amino acids, silymarins, Tea extract and grape skin / seed extract. Preferred antioxidants / radical scavengers are selected from grape husk / seed extracts, tea extracts and esters of tocopherols, more preferably tocopherol acetate.

5. Chelating Agent

Exemplary chelating agents useful in the present invention are disclosed in US Pat. No. 5,487,884.

6. Flavonoids

Flavonoids are widely disclosed in US Pat. No. 5,686,082 and US Pat. No. 5,686,367. Examples of particularly suitable flavonoids for use in the present invention include one or more flavones, one or more chalcones, one or more flavanones (eg, hesperidin), one or more isoflavones, one or more coumarins, one or more chromones, one or more dicumas Rolls, one or more chromanones, one or more chromanols, isomers thereof (eg cis / trans isomers) derivatives thereof and mixtures thereof. Preferred for use in the present invention are flavones and isoflavones, in particular dydzein (7,4'-dihydroxy isoflavones), genistein (5,7,4'-trihydroxy isoflavones), equol (7 , 4'-dihydroxy isoflavone), 5,7-dihydroxy-4'-methoxy isoflavone, soybean isoflavone (a mixture extracted from soybean), and mixtures thereof.

7. Anti-inflammatory

Steroidal anti-inflammatory agents include, but are not limited to, corticosteroids such as hydrocortisone. A second class of anti-inflammatory agents useful in the present compositions includes nonsteroidal anti-inflammatory agents. Various compounds included in this group are well known to those skilled in the art. Certain nonsteroidal anti-inflammatory agents useful in the compositions of the present invention include, but are not limited to, salicylate, flufenamic acid, etophenamate, aspirin and mixtures thereof.

Further anti-inflammatory agents useful in the present invention are compounds with licorices (Glycyrrhiza glabra / genus of plants / species), including glycyrrhetinic acid, glycyric acid and derivatives thereof (e.g. salts and esters) and Includes allantoin.

8. Anti-Cellulite

The compositions of the present invention may optionally contain a safe and effective amount of an anticellulite agent. Suitable formulations include, but are not limited to, xanthine compounds (eg, caffeine, theophylline, theobrom and aminophylline).

9. Tanning Activator

Preferred tanning actives are dihydroxyacetone.

10. Skin Whitening Agent

Suitable skin whitening agents include kojic acid, arbutin, tranexamic acid, ascorbic acid and derivatives thereof (eg, magnesium ascorbyl phosphate or sodium ascorbyl phosphate, ascorbyl glucoside, etc.). It is included. Other skin lightening materials suitable for use in the present invention include Actiwhite® (Cognis), Emmblica® (Rona), Azeloglysina ( Azeloglicina (Sinerga), Sepiwhite, hexamidine, sugar amines (e.g. N-acetyl glucosamine), phytosterols (e.g. one or more cytosterols, stigmasterols, campestrols, bras Cysterol and the like), and extracts (eg, mulberry extracts).

11. Antimicrobial and antifungal actives

Preferred examples of active agents useful in the present invention are salicylic acid, benzoyl hydrogen peroxide, 3-hydroxybenzoic acid, glycolic acid, lactic acid, 4-hydroxy benzoic acid, acetyl salicylic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2- Hydroxyhexanoic acid, cis-retinic acid, trans-retinic acid, retinol, phytic acid, N-acetyl-L-cysteine, lipoic acid, azelaic acid, arachidonic acid, benzoyl peroxide, tetracycline, ibuprofen, naproxen, hydrocortisone, aceto Minophene, resorcinol, phenoxyethanol, phenoxypropanol, phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarbanide , Octopyrox, lidocaine hydrochloride, clotrimazole, myconazole, ketoconazole, neocycin sulfate, and mixtures thereof.

12. Sunscreen Actives

Suitable sunscreen actives may be organic or inorganic. Sagarin, et al., At Chapter VIII, pages 189 et seq. Of Cosmetics Science and Technology (1972) disclose many suitable active agents. Additional active agents can be found in The European Union Cosmetics Directive 76/768 / EEC, Annex VII. Non-limiting examples of suitable sunscreen agents include octinoxate, avobenzone, oxybenzone, octocrylene, octysalate, homosalate, meradimate, ensulazole, zinc oxide, titanium dioxide and mixtures of these compounds do.

13. Conditioning agents

The composition of the present invention may contain a conditioning agent selected from the group consisting of humectants, humectants, hair conditioners, or skin conditioners comprising emollients. A variety of these materials can be used, each of which is about 0.01% to about 100%, more preferably about 0.1% to about 30%, even more preferred, at a safe and effective level, preferably based on the weight of the composition. Preferably from about 0.5% to about 25%. These substances include guanidines; Urea; Glycolic acid and glycolate salts; Lactic acid and lactate salts; Aloe vera in any of its various forms (eg, aloe vera gel); Polyhydroxy compounds such as sorbitol, mannitol, glycerol, hexanetriol, butanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; Polyethylene glycol; Sugars (eg melibiose) and starch; Sugar and starch derivatives (eg, alkoxylated glucose, fructose, sucrose, etc.); Hyaluronic acid; Panthenol and panthenol derivatives; Lactamide monoethanolamine; Acetamide monoethanolamine; Sucrose polyester; vaseline; Silicones and silicone elastomers; Hydrocarbon oils; Fatty alcohols; Fatty acids and esters; Esters of monobasic and dibasic carboxylic acids with mono and polyhydric alcohols; Polyolefins, polyoxyethylenes; Polyoxypropylene; Mixtures of polyoxyethylene ethers and polyoxypropylene ethers of fatty alcohols and mixtures thereof, including but not limited to. Many conditioning agents are fat materials that are pliable and slippery and not only conditioned but also smooth to the touch.

Silicones useful in the compositions of the present invention include polyalkylsiloxanes having a viscosity at about 25 ° C. of about 5 × 10 ⁻⁷ to about 1 m 2 / s (about 0.5 to about 1,000,000 centistokes). Further silicones suitable for use in the present invention include silicone elastomers, including silicone emulsified or non-emulsified crosslinked siloxane elastomers, silicone rubbers, silicone resins, amino silicones, cationic silicones, highly refractive silicones or mixtures thereof. Emulsified crosslinked organopolysiloxane elastomers can be specifically selected from the crosslinked polymers disclosed in US Pat. No. 5,412,004, US Pat. Nos. 5,837,793 and 5,811,487.

Advantageously, the non-emulsifying elastomer is a dimethicone / vinyl dimethicone crosspolymer. Such dimethicone / vinyl dimethicone crosspolymers include Dow Corning (DC 9040, DC 9041, DC9045), General Electric (SFE 839), Shin Etsu (KSG-15, 16, 18) and Grant Industries (elastomers of the GRANSIL ™ line). Crosslinked organopolysiloxane elastomers and methods of making them useful in the present invention are further described in US Pat. No. 4,970,252, US Pat. No. 5,760,116, and US Pat. No. 5,654,362. Further crosslinked organopolysiloxane elastomers useful in the present invention are disclosed in Japanese Patent Application No. 61-18708, assigned to Pola Kasei Kogyo KK.

Preferably, the conditioning agent is selected from the group consisting of glycerol, urea, petrolatum, sucrose polyesters, silicones, esters and combinations thereof.

14. Vitamins

Examples of vitamins include water soluble versions of vitamin B, vitamin B derivatives, vitamin C, vitamin C derivatives, vitamin K, vitamin K derivatives, vitamin D, vitamin D derivatives, vitamin E, vitamin E derivatives, and mixtures thereof. It is not limited to this. This vitamin compound may be included as a fairly pure substance or as an extract obtained by suitable physical and / or chemical separation from natural sources (eg plants).

15. Particulate matter

Non-limiting examples of particulate material useful in the present invention include colored and uncolored pigments, interference pigments, inorganic powders, organic powders, composite powders, optical brightener particles, exfoliants and combinations thereof. Such particulates may be platelet, spherical, elongated or needled, or indeterminate, surface coated or uncoated, porous or nonporous, charged or uncharged and may be added to the compositions of the present invention as powders or predispersions. Can be.

Particulate materials useful in the present invention include mica, zeolite, kaolin, silica, boron nitride, lauroyl lysine, nylon, polyethylene, talc, styrene, polytreated with bismuth oxychloride, mica, mica, barium sulfate or other materials. Propylene, polystyrene, ethylene / acrylic acid copolymers, mica, aluminum oxide, silicone resin, barium sulfate, calcium carbonate, cellulose acetate, PTFE, polymethyl methacrylate, starch, modified starch, for example aluminum starch octenyl succinate, Silk, glass, fiber, micronized seed, pumice and mixtures thereof. Especially preferred are spherical powders having an average primary particle size of 0.1 to 75 microns, preferably 0.2 to 30 microns.

Also useful in the present invention are interference pigments. For the purposes of this specification, interference pigments generally produce a characteristic reflection color from interference of two, but in some cases more reflected light, from different layers of lamellar particles in a controlled thickness with different refractive indices. It is defined as lamellar particles in the form of lamina with two or more layers of. The most common examples of interference pigments are mica layered with TiO 2, Fe 2 O 3, silica, tin oxide, and / or Cr 2 O 3 in films of about 50-300 nm. Such pigments are often pearlescent. Pearlescent pigments reflect, refract, and pass light due to large differences in the transparency of the pigment particles and the refractive index of platelet-shaped mica, for example due to titanium dioxide coating. Useful interference pigments are available from a wide variety of suppliers such as Rona (Timiron ™ and Dichrona ™), Eckart (eg, Prestige and Prestige Silk lines). Available from. Especially preferred are interference pigments having a smaller particle size and an average diameter of the individual particles less than about 75 microns in the longest direction, and preferably an average diameter of less than about 50 microns.

Other pigments useful in the present invention provide color primarily through selective absorption of visible light of a particular wavelength, which includes inorganic pigments, organic pigments and combinations thereof. Examples of useful inorganic pigments include iron oxide, ferric ammonium ferrocyanide, manganese violet, ultramarine blue, and chromium oxide. Organic pigments may include natural colorants and synthetic colorants that are monomeric and polymeric. Examples are phthalocyanine blue and green pigments. Also useful are rakes, primary FD & C or D & C rakes and blends thereof. Also useful are encapsulated soluble or insoluble dyes and other colorants. Inorganic white or uncolored pigments useful in the present invention, such as TiO 2, ZnO, or ZrO 2, are commercially available from a number of sources. One example of a suitable particulate material is US. Materials available from U.S. Cosmetics (TRONOX TiO2 series, SAT-T CR837, Rutile TiO2). Especially preferred are charged titanium dioxide dispersions as disclosed in US Pat. No. 5,997,887.

Pigments / powders useful in the present invention may be surface treated to provide added color stability and / or ease of formulation. Non-limiting examples of suitable coating materials include silicones, lecithins, amino acids, metal soaps, polyethylenes and collagen. Such surface treatment may be hydrophobic or hydrophilic, with hydrophobic treatment being preferred. Particularly useful hydrophobic pigment treatments include polysiloxane treatments such as those disclosed in US Pat. No. 5,143,722.

16. Sugar Amine (Amino Sugars)

Sugar amine compounds useful in the present invention are disclosed in WO 02/076423 and US Pat. No. 6,159,485.

Sugar amines can be synthetic or natural in origin and can be used as pure compounds or mixtures of compounds (eg, extracts from natural sources or mixtures of synthetic materials). Glucosamine is commonly found in many crustaceans and can also be derived from fungal sources. As used herein, "sugar amine" includes isomers and intervariants and salts thereof (eg, HCl salts) and is commercially available from Sigma Chemical Co.

Examples of sugar amines useful in the present invention include glucosamine, N-acetyl glucosamine, mannosamine, N-acetyl mannosamine, galactosamine, N-acetyl galactosamine, isomers thereof (e.g., stereoisomers), and Salts thereof (eg, HCl salts). Preferred for use in the present invention are glucosamine, in particular D-glucosamine and N-acetyl glucosamine, in particular N-acetyl-D-glucosamine.

17. Vitamin B ₃ compound

The compositions of the present invention may optionally contain a safe and effective amount of a vitamin B ₃ compound. Vitamin B ₃ compounds are particularly useful for regulating skin conditions as disclosed in US Pat. No. 5,939,082.

Exemplary derivatives of the aforementioned vitamin B ₃ compounds include esters of nicotinic acid, including vascular non-dilating esters of nicotinic acid (eg, tocopheryl nicotinate, myristyl nicotinate).

Examples of suitable vitamin B ₃ compounds are well known in the art and include a number of sources (e.g., Sigma Chemical Company, ICN Biomedicals, Inc.) and Aldrich Chemical Company. Available from)).

18. Retinoids

As used herein, "retinoid" includes all natural and / or synthetic analogues of vitamin A or retinol-like compounds having the bioactivity of vitamin A in the skin, as well as the geometric and stereoisomers of these compounds. Retinoids are preferably retinol, retinol esters (e.g., C ₂ -C ₂₂ alkyl esters of retinol including retinyl palmitate, retinyl acetate, retinyl propionate), retinal, and / or retinic acid (Including all-trans retinic acid and / or 13-cis-retinic acid), or mixtures thereof. More preferably, the retinoid is a retinoid other than retinic acid. Preferred retinoids are retinol, retinyl palmitate, retinyl acetate, retinyl propionate, retinal and combinations thereof. Even more surprising is retinyl propionate.

19. Peptides and Amino Acids

The compositions of the present invention may optionally contain a safe and effective amount of a peptide, including but not limited to di-, tri-, tetra-, penta- and hexa-peptides and derivatives thereof, for the control of keratinous tissue. have. The composition is preferably from about 1 × 10 ⁻⁷ % to about 20%, more preferably from about ¹ × 10 ⁻⁶ % to about 10%, even more preferably from about 1 × 10 ⁻⁵ % to about 5% by weight of the composition Peptide or amino acid.

As used herein, "peptide" refers to peptides containing up to 10 amino acids and derivatives, isomers, and other chemical species such as metal ions (eg, copper, zinc, manganese, magnesium, etc.). Refers to a complex with As used herein, peptide refers to both naturally occurring peptides and synthesized peptides. Naturally occurring and commercially available compositions containing peptides are also useful in the present invention. More preferred peptides include dipeptide cannosine (beta-ala-his), tripeptide gly-his-lys, pentapeptide lys-thr-thr-lys-ser, lipophilic derivatives of the peptide, and metal complexes thereof, eg For example, a copper complex of tripeptide his-gly-gly (also known as an amine). Preferred commercially available tripeptide derivative-containing compositions are Biopeptide CL®, which contains 100 ppm of palmitoyl-gly-his-lys and is commercially available from Sederma. Preferred commercially available pentapeptide derivative-containing compositions are Matrixyl® containing 100 ppm palmitoyl-lys-thr-thr-lys-ser and commercially available from Cedar.

Useful amino acids include, but are not limited to, asparagine, alanine, indole, glutamic acid, tyrosine, tryptamine, and salts thereof and combinations thereof.

20. Phytosterol

-스피나스테롤, 스티그마스테롤, 그 유도체, 유사체 및 이들의 조합이 포함된다. 바람직하게는, 피토스테롤은 β-시토스테롤, 캄페스테롤, 브라시카스테롤, 스티그마스테롤, 그 유도체 및 이들의 조합으로 이루어진 군으로부터 선택된다. 더 바람직하게는, 피토스테롤은 스티그마스테롤이다.Examples of suitable phytosterols include β-sitosterol, camphorsterol, brassicasterol, D5-avenasterol, luphenol,

Spinasterol, stigmasterol, derivatives thereof, analogs and combinations thereof. Preferably, the phytosterol is selected from the group consisting of β-sitosterol, camphorsterol, brassicasterol, stigmasterol, derivatives thereof and combinations thereof. More preferably, the phytosterol is stigmasterol.

Phytosterols can be synthetic or natural in origin and can be used as essentially pure compounds or mixtures of compounds (eg, extracts from natural sources). Phytosterols are generally found in non-saponifiable parts of vegetable oils and are available as free sterols, acetylated derivatives, sterol esters, ethoxylated or glycoside derivatives. More preferably, the phytosterol is free sterol. As used herein, "phytosterol" includes isomers and intervariants and is commercially available from Aldrich Chemical Company, Sigma Chemical Company, and Cognis.

21.Hexamidine

The compositions of the present invention may optionally contain a safe and effective amount of hexamidine compounds, salts and derivatives thereof for controlling keratinous tissue.

As used herein, hexamidine derivatives include any isomers and intervariants of hexamidine compounds, including but not limited to organic and inorganic acids, such as sulfonic acids, carboxylic acids, and the like. Preferably, the hexamidine compound comprises hexamidine diisethionate, available as Elestab® HP100 from Laboratoires Serobiologiques.

22. Dialkanoyl Hydroxyproline Compound

The compositions of the present invention may optionally contain a safe and effective amount of one or more dialkanoyl hydroxyproline compounds and salts and derivatives thereof for controlling keratinous tissue.

Suitable derivatives include, but are not limited to, esters such as fatty esters, including but not limited to tripalmitoyl hydroxyproline and dipalmityl acetyl hydroxyproline. Particularly useful compounds are dipalmitoyl hydroxyproline. As used herein, dipalmitoyl hydroxyproline, including any isomers and intervariants thereof, is purchased from Seppic, Inc. under the trademark Sepilift DPHP®. It is possible. Further discussion of dipalmitoyl hydroxyproline is presented in WO 93/23028. Preferably, dipalmitoyl hydroxyproline is the triethanolamine salt of dipalmitoyl hydroxyproline.

23. Salicylic Acid Compounds

The compositions of the present invention may optionally contain a safe and effective amount of salicylic acid compound, ester thereof, salt thereof, or a combination thereof for controlling keratinous tissue.

24. N-acyl Amino Acid Compound

The topical compositions of the invention may optionally contain a safe and effective amount of one or more N-acyl amino acid compounds. This amino acid may be one of any amino acids known in the art. Preferably, the N-acyl amino acid compound is selected from the group consisting of N-acyl phenylalanine, N-acyl tyrosine, isomers thereof, salts thereof and derivatives thereof. This amino acid may be the D or L isomer or mixtures thereof.

Particularly useful as topical cosmetic preparations that even out skin tones are N-undecylenoyl-L-phenylalanine. As used herein, N-undecylenoyl-L-phenylalanine is commercially available from SEPPIC under the trademark Sepiwhite®.

25. Dehydroacetic acid (DHA)

The compositions of the present invention may optionally contain a safe and effective amount of dehydroacetic acid or a pharmaceutically acceptable salt, derivative or intervariant thereof for controlling keratinous tissue. The technical name of dehydroacetic acid is 3-acetyl-6-methyl-2H-pyran-2,4 (3H) -dione. This compound can be purchased as Unisept DHA from UniversalPreserv-A-Chem, Inc.

Pharmaceutically acceptable salts include alkali metal salts such as sodium and potassium; Alkaline earth metal salts such as calcium and magnesium; Nontoxic heavy metal salts; Ammonium salts; And trialkylammonium salts such as trimethylammonium and triethylammonium. Preferred are the sodium, potassium and ammonium salts of dehydroacetic acid. Very preferred is sodium dehydroacetate, which can be purchased from Tri-K as Tristat SDHA. Derivatives of dehydroacetic acid include, but are not limited to, any compound in which the CH3 group is replaced by amide, ester, amino group, alkyl or alcohol ester individually or in combination. Intermoders of dehydroacetic acid are isomers of dehydroacetic acid that can be changed into each other very easily and thus usually exist in equilibrium. Thus, intervariants of dehydroacetic acid have the general formula C 8 H 8 O 4 and can be described as having the above structure in general.

26. Skin Firming Agents:

Skin firming agents are substances that produce an immediate firming feeling or tightness immediately after application to the skin. In addition, through these tightening or skin tension effects, these materials may also provide the effect of visually smoothing the skin, thereby reducing skin texture, fine lines and wrinkle appearance.

Non-limiting examples of skin firming agents useful in the present invention include various natural and synthetic polymers, such as those disclosed in US Pat. No. 6,284,233, incorporated herein by reference. For example, protein extracts from wheat and peas, or egg albumin, are effective skin firming agents. Other materials, such as the silicates disclosed in European Patent No. 1008340, also incorporated herein by reference, are also suitable for use in the compositions of the present invention.

27. Anti-dandruff activator

Particulate crystalline preparations dispersed and suspended throughout the topical composition may provide anti-dandruff activity during the shampooing process.

Anti-dandruff active agents used for this purpose include polyvalent metal salts of pyrithione, salicylic acid, coal tar, pine tar, sulfur, whitfield's ointment, castellani's paint, aluminum chloride, gentian violet, octopyrox (Pyroxtone olamine), cyclopyroxolamine, undecylenic acid and metal salts thereof, potassium permanganate, selenium sulfide, sodium thiosulfate, propylene glycol, bitter orange oil, urea preparations, griofulvin, 8-hydroxyquinoline siloquinol , Thiobendazole, thiocarbamate, haloprozin, polyene, hydroxypyridone, morpholine, benzylamine, allylamine (e.g. terbinafine), tea tree oil, melaleuca (tea tree) Extract, charcoal, clove leaf oil, coriander, palmarosa, berberine, thyme red, climbasole, cinnamon oil, cinnamic aldehyde, citronelic acid, hyaluronic acid Kitol, ichthyol pale, Sensiva SC-50, Elestab HP-100, azelaic acid, lyticase, iodopropynyl butylcarbamate (IPBC) Isothiazolinones such as octyl isothiazolinone and azoles, and combinations thereof.

Other ingredients

The compositions of the present invention may contain a wide variety of ingredients used in conventional product types, provided they do not alter the effects of the present invention unacceptably. In addition, when incorporated into the present compositions, these ingredients should be suitable for use in contact with mammalian keratinous tissue without undue toxicity, incompatibility, instability, allergic reactions, etc. within the scope of reasonable judgment. CTFA Cosmetic Ingredient Handbook, Second Edition (1992) describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients that are commonly used in keratinous tissue care and suitable for use in the compositions of the present invention. Examples of such and similar component classes include abrasives, absorbents, aesthetic ingredients such as perfumes, pigments, colorants / colorants, essential oils, skin sensates, astringents, and the like (eg, clove oil, menthol, camphor). , Eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate, antiacne, anticaking agent, antifoaming agent, antimicrobial agent (e.g. iodopropyl butylcarbamate), antioxidant, binder , Biological additives, buffers, extenders, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, medicinal astringents, emollients, external analgesics, film formers or materials, eg film-forming properties Polymers (eg, copolymers of eicosene and vinyl pyrrolidone), cationic polymers (eg quaternary ammonium or cationic protonated amino moieties) to aid in the sustainability of the composition , Nonionic polymers, wetting agents, opacifiers, pH adjusters, propellants, reducing agents, metal ion sequestrants, skin bleaching and whitening agents, hair and skin conditioning agents, skin soothing and / or healing agents and derivatives, hair and skin treatment agents, surfactants , Thickeners, and vitamins and derivatives thereof Further examples of suitable emulsifiers and surfactants are described, for example, in US Pat. No. 3,755,560, US Pat. No. 4,421,769, and McCutcheon's Detergents and Emulsifiers, North American Edition, pages 317324. (1986), however, it should be understood that many substances may provide more than one effect or may operate through more than one mode of action. Are for convenience and are not intended to limit the active to the specific uses or uses listed.

Composition form

The physical form of the topical composition is not critical. The topical compositions of the present invention may be in any form known in the art, including but not limited to solutions, suspensions, dispersions, emulsions, and combinations thereof.

For example, emulsion carriers, including but not limited to oil-in-water, water-in-oil, oil-in-water, and oil-in-water emulsions, are useful in the present invention. In emulsion systems, as will be appreciated by those skilled in the art, a given component will be predominantly dispensed into the water or oil phase depending on the water solubility / dispersibility of the components in the composition. Particularly preferred emulsions when all or part of the oil phase is silicone or silicone blend are oil-in-water emulsions and water-in-oil emulsions.

Water-in-oil emulsions may extend the duration of detection of the warmth of the composition when applied to keratinous tissue. Without wishing to be bound by theory, it is believed that water will evaporate more slowly because it is in the discontinuous phase of the emulsion, and therefore the cooling rate of the product film on the surface will be slower. This is due to the fact that evaporation is a cooling process. In one embodiment, the composition is a water-in-oil emulsion and most oils are silicones. Compositions of this type are often called water-in-silicone emulsions.

Non-limiting examples of emulsifiers useful in the emulsions of the present invention are described in McCutcheon's, Detergents and Emulsifiers, North American Edition (1986), published by Allured Publishing Corporation; US Patent No. 5,011,681; US Patent No. 4,421,769; And US Pat. No. 3,755,560. Exemplary carriers and other ingredients suitable for use in the present invention are disclosed, for example, in US Pat. No. 6,060,547.

The duration of detection of warmth may also be extended by the inclusion of one or more waxy materials having a melting point of about 30 ° C to about 80 ° C. Such compositions contain more than about 1%, more preferably greater than about 2.0%, even more preferably greater than about 2.5% of such waxy materials by weight or weight of the composition. Without wishing to be bound by theory, these waxy materials melt when the composition is heated in the vesicles, and then when applied to the keratinous tissue, the melted waxy material re-crystallizes to release heat and thus the product on the surface. Cooling rate is reduced.

As will be appreciated by those skilled in the art, the topical compositions of the present invention may exhibit a wide range of viscosities, depending on the type and level of thickener (s) or structurant (s) contained in the formulation. In particular, the compositions range from very thin and flowable (liquid, milk, lotion, serum, thin gel) products to darker products (creams, darker gels, pastes, ointments), even semi-solids and solids (powders, sticks). Can be.

As measured using a commercially available viscometer / flow meter (e.g., Brookfield Model Series DV-II and DV-III Viscometers from Brookfield Engineering Laboratories, Inc.) Viscosity is one known method of characterizing the thickening of a composition. In one preferred embodiment of the invention, the viscosity of the topical composition is between 10 Pa.s and 500 Pa.s (10,000 cps to 500,000 cps) as measured at the target temperature of the topical composition. In another preferred embodiment of the invention, the viscosity of the topical composition at the target temperature is at least 50%, even more preferably at least 80% of the viscosity at 22 ° C. In this way, the composition does not become excessively diluted or difficult to handle during application, and its rheological properties are relative regardless of whether the product is used at room temperature or at any temperature below the target temperature of the heater system. Will remain constant.

The topical compositions of the present invention can be detergents, including but not limited to shampoos, body washes, liquid soaps and scrubs. The topical compositions also include moisturizers; Anti aging products; Sunscreen; Pharmaceutical products; Dermatological products; Hair colorants; Hair conditioner; Antiperspirant; deodorant; toothpaste; Cosmetics including, but not limited to, foundations, blush mascara, lipsticks, and nail polishes; Hair loss agents; Patches, masks; It may be a massage product.

The topical composition may optionally contain a substance that changes color or opacity level when the topical composition is warmed. This produces a visible signal based on the topical composition.

Composition preparation

Compositions of the present invention are generally prepared by conventional methods known in the art for preparing topical compositions. Such methods typically involve mixing the components in a relatively uniform state in one or more steps, with or without heating, cooling, vacuum application, and the like. The composition is preferably prepared to optimize the stability (physical stability, chemical stability, photostability) and / or delivery of the active substance. This optimization may include the use of approaches for appropriate pH (e.g., less than 7), exclusion of substances that may be combined with the active agent and adversely affect stability or delivery (e.g., elimination of contaminant iron), and approaches for the prevention of complex formation. Use (eg, suitable dispersants or double compartment packaging), use of appropriate light stability approaches (eg, incorporation of sunscreens / sunscreens, use of opaque packaging), and the like.

The following is a non-limiting example of a composition of the present invention. As many variations are possible without departing from the spirit and scope of the invention, this embodiment is provided for illustrative purposes only and should not be construed as a limitation of the invention, as will be appreciated by those skilled in the art. In the examples, all concentrations are listed in weight percent unless otherwise specified, and minor materials such as diluents, fillers and the like may be excluded. Thus, the listed formulations include the listed components and any trace substances associated with those components. As will be apparent to those skilled in the art, the choice of such traces will depend upon the physical and chemical properties of the particular ingredients selected to make the present invention as described herein.

Example 1-3: Water-in-silicone emulsion type lotion / serum

In a suitable container, the carbopol and water phase components are combined and then blended until uniform. The oil phase components are combined in individual suitable containers and blended until uniform. The oil phase is then added to the water phase and the resulting emulsion is ground (eg using a rotor-stator grinder). Non-carbopol thickener and the remaining additional ingredients are added to the emulsion and blended until uniform. Fill the vesicles suitable for use with the receptacle.

Example 4-8: Oil Type Lotion / Cream

Combine the aqueous phase components in a suitable vessel and heat to 75 ° C. The oil phase components are combined and heated to 75 ° C. in separate suitable containers. The oil phase is then added to the water phase and the resulting emulsion is ground (eg using a rotor-stator grinder). The thickener is then added to the emulsion and the emulsion is cooled to 45 ° C. with stirring. Add the remaining ingredients at 45 ° C. The product is cooled to 30 ° C. and stirred. Fill the vesicles suitable for use with the receptacle.

Examples 9-13: Silicones in Water Serum / Lotion:

Combine the water phase components in a suitable container and mix until uniform. Combine the silicone / oil phase components in separate suitable containers and mix until uniform. Separately, the dipalmitoyl hydroxyproline premix and / or undecylenyl phenylalanine premix components in a suitable container are combined, heated to about 70 ° C. with stirring, and cooled to room temperature with stirring, and / or the dipalmitoyl hydroxyproline premix and / or Or undecylenoyl phenylalanine premix is prepared. Half of the thickener, then the silicone / oil phase, is added to the water phase and the resulting emulsion is ground (eg using a rotor-stator grinder). If applicable, the remaining thickener, dipalmitoyl hydroxyproline premix and / or undecylenoyl phenylalanine premix, and then the remaining ingredients are added to the emulsion with stirring. Stir until the composition is uniform. Fill the vesicles suitable for use with the receptacle.

Examples 14-19 Moisturizing Silicone Water-Based Cream / Lotion:

In a suitable container, phase A components are blended together in a suitable mixer (eg, Techma Model RW20DZM) and mixed until all components are dissolved. The phase B components are then blended together in a suitable container and ground for about 5 minutes using a suitable grinder (eg, Techma RW-20). Add phase C ingredients to the phase B mixture while mixing. The phase D component is then added to the mixture of phases B and C and the resulting combination of phases B, C and D is then mixed for about 1 hour using a suitable mixer (eg Techma RW-20). . If applicable, the undecylenyl phenylalanine premix and / or phase E are prepared by combining all components and heating to 70 ° C. with stirring and cooling back to room temperature with stirring. Undecylenyl phenylalanine premix and / or phase E are added to phase A with mixing. Next, phase A is slowly added to the mixture of phases B, C, D while mixing. The resulting mixture is continuously mixed until the product is uniform. The resulting product is ground for about 5 minutes using an appropriate mill (eg Techma T-25). Fill the vesicles suitable for use with the receptacle.

Examples 20-23: Solid Formulations Based on Water

All ingredients are combined into a container of the appropriate size, heated to 85 ° C. and cooled. The vesicles are filled suitable for use with the receptacle of the present invention at approximately 65-70 ° C.

Examples 24-27: Anhydrous Solid Formulations

All ingredients are added to a vessel of the appropriate size, heated to 75 ° C. and then cooled with stirring until the mixture reaches approximately 45-50 ° C. Fill the vesicles suitable for use with the receptacle.

Examples 28-29: aqueous gel formulation

Combine all ingredients into a container of the appropriate size and mix until uniform. Fill the vesicles suitable for use with the receptacle.

Example 30: Shampoo Formulations

Combine all ingredients into a container of the appropriate size and mix until uniform. Fill the vesicles suitable for use with the receptacle.

Example 31 Face Cleanser

Water, glycerin and disodium EDTA are mixed in a suitable vessel and heated to 75-80 ° C. with stirring. In a separate vessel, PPG-14 butyl ether and salicylic acid are heated to 75-80 ° C. with stirring to form an oil phase. Stearyl alcohol, cetyl alcohol and behenyl alcohol are then added to the oil phase with continued heating while stirring. Next, distearyl dimethyl ammonium chloride, stearet-2 and stearet-21 are added to the oil phase while still heating and stirring. This oil phase is then emulsified into a water containing mixture using a homogenization mill. The resulting emulsion is cooled to 45 ° C. with stirring and urea and perfume are added. The emulsion is cooled to room temperature with stirring. Sodium alkyl sulfate and cetyl betaine are then mixed, followed by polyethylene particles.

Example 31 Hair Coloring Agent

Example 32: Foaming Face Wash

The water is heated to 65 ° C. Polyquaternium-10 is added to water to form phase A. The components of phase B are added sequentially to the phase. The components of phase C are individually heated to 65 ° C. Phase C is combined with the mixture. Phases A, B and C are then cooled to 40 ° C. Phase D and Phase E are added to the mix to form the resulting cosmetic composition.

Examples 33-34: Liquid Foundation Compositions

The silica shells and deionized water of phase D are combined and mixed with a propeller or disperser until homogeneous. Add the remaining phase D components and continue propeller or disperser blending. Combine phase A ingredients in a jacketed vessel and begin mixing with the rotor-stator grinder. Recycle cold water through the jacketed container. Phase B components are blended together for 10 minutes. Blended phase B is added into phase A component. Phase C component is added into phase AB. Phase ABC is subjected to shearing force until the phase is completely deagglomerated and the pigment is reduced to its primary particle size. Phase D is emulsified into phase ABC under moderate shear force. Phase ABCD is blended with sweep wall mixing until uniform. Fill the vesicles suitable for use with the receptacle.

Example 35 Disposable Wipes

About 96.4% water, 2% silicone oil, 0.15% carboxylic acid polymeric emulsifier, 1% water soluble alkylene polyol, 0.1% chelating agent, 0.2% antimicrobial agent, 0.15% organic An emulsion (composition A) containing a base pH-adjusting agent and a perfume is prepared.

Emulsions are prepared using a standard size 208 L (55 gallon) enclosed cylindrical drum equipped with a single shaft with double propeller blades driven by a motor at a speed of 178 rad / s (1750 rpm). The shaft extends substantially through the depth of the drum (about 1.2 m (4 feet)) and includes a first blade positioned near the base of the drum and a second shaft located about 0.3 m (1 foot) above the first blade. Have The diameter of the first blade is about the same as the drum diameter (about 0.6 m (2 feet)) and the diameter of the second blade is about 0.3 m (1 foot).

Fill the drum with 151-181.7 L (40-48 gallon) of tap water. The water begins to stir by running the motor at its maximum speed. Stirring is continued at this rate throughout the entire process.

236 g (0.52 lbs.) Of Pemulen® TR-2 are added slowly to allow sufficient emulsifier to mix with water to disperse the emulsifier mass or to prevent its formation. The following ingredients are then added in the order mentioned: 158.7 g (0.35 lbs) tetrasodium EDTA; 1.5 kg (3.49 lbs) propylene glycol; 3.2 kg (6.97 lbs) of dimethicone (Dow Corning 200 Fluid, 0.00035 m 2 / s (350 cs)); 317.5 g (0.70 lbs) Glidant Plus®; 4.5 g (0.01 lbs) of perfume. Typically, by stirring for a period of about one minute between the addition of the individual components, and for a period of about 5-10 minutes once all the components are in the container, until each of the above components is well blended into the resulting mixture Mix separately into water. 235.9 g (0.52 lbs) of triethanolamine is then added and stirring is continued for a period of about 15-20 minutes or until the mixture is well blended.

Wipes consisting of two layers of cellulose based 100% NSK fibers having a basis weight of 11.3 kg (26 lbs) per ply and 508 μm (20 mils) per ply are laminated together under pressure with an adhesive and wound with a continuous web roll. The wet strength of a suitable adhesive is sufficient to allow the plies to remain substantially bonded during use. Slit the web roll to achieve the desired width of the final wipe (e.g. 29.2 cm (11.5 ") in unfolded form) and the z-shaped fold so that the machine direction edges overlap about 1.27 cm (0.5"). .

The slits and folded final webs are then impregnated with Composition A by passing the individual webs over the top of the individual manifolds with holes that allow the composition to be pumped onto the moving web under pressure. The composition is pumped to provide a drop of about 15.5 grams of the composition per finished wipe.

Following impregnation, the web is cut to the length of the desired finished wipe (eg, about 21.6 cm (8.5 ").) The wipe is inserted into a vesicle suitable for use with the receptacle of the present invention.

follicle

The vesicles used in the present invention comprise a plurality of surfaces forming one or more chambers for containing the composition. Thus, although vesicles with only one chamber are frequently used, multiple chambers or multi-chambered vesicles can also be used in the present invention. Typically, one or more vesicle surfaces have low thermal resistance. Since the heating system can be connected to more than one wall of the receptacle, the vesicles with various surfaces with variable thermal resistance will heat up quickly and evenly.

The vesicles may be prepared by using a wide variety of materials alone or in combination. The surface of the vesicles may be thick or thin. In addition, the material may be selected to provide the desired thermal resistance, light resistance, oxygen barrier and moisture barrier. In a preferred embodiment, the vesicles comprise a film formed from a wholly or partially blended or metallized single or multilayer plastic, polymer or foil or combinations thereof. Examples of such materials are polyolefin, polyester, nylon, polypropylene, polyethylene, ethylene vinyl acetate, metallized PET (polyethylene terephthalate), aluminum foil, EVOH (ethylene-vinyl alcohol copolymer), PVDC (polyvinylidene chloride) Etc. Other materials can be used, including but not limited to cardboard. Examples of materials used for vesicles are polyethylene / ethylene vinyl acetate inside as the outer coextruded polypropylene film and sealant layer. Similar vesicles are available from Flexpaq, South Plains, NJ.

Various means of opening the vesicles are known in the art and can be used with the vesicles disclosed herein. This includes, but is not limited to, peeling by pull tabs, tearing along cut lines, compression, and the like. Resealable vesicles are also contemplated.

In some embodiments, the vesicles can be designed to disintegrate or rupture with relatively little force when desired by the consumer to release the topical composition contained within the vesicles. This may be achieved by allowing the vesicles to be pouches sealed with both a permanent seal and also a "weak", ie sealable seal. When the vesicles are squeezed, the weak seal will first loosen or break down because the peel force that breaks the seal is lower than the permanent seal. The rupture location can be optimized by adding a stress concentrator to the seal geometry that can gather forces at a specific location. For example, pressing a pouch-shaped vesicle with a V notched seal will first confine the force at the apex of the V notch, causing the area to rupture first. In addition, other angles and geometries of the seal can also be used to tailor the dispensing force for removal of the topical composition from the vesicle for a particular use. Further discussion of rupturable seals, including manufacturing methods, is shown in US Pat. No. 6,508,602.

The embodiment of the vesicle shown in FIG. 5A is a thermoformed blister pack 500 with tear tabs 510 that allow the topical composition to dispense when tear tabs 510 are removed along perforation 540. This type of vesicle is made by thermoforming the front face 550 of the vesicle from a sheet of material so that it forms a small chamber 520 for containing the topical composition. The chamber 520 is then filled and then sealed around the periphery 560 of the chamber to include the topical composition until another layer of material forming the back 530 is ready for use. 5B-5D provide further drawings of this embodiment. 5E is a cross-sectional view of the vesicle of FIG. 5A taken along line A-A, showing topical composition 560 in chamber 520. Other methods of preparation in the form of vesicles, pouches, packets, blisters, cells, thermoformed cups, vesicles, and other vesicles for containing liquids, gels or solids are known in the art and may be used to prepare reservoirs suitable for such uses. Can be used.

The vesicles may comprise a plurality of compartments. Such “double” or multi-compartment vesicles are useful for many applications, especially when two incompatible products are applied. FIG. 6A illustrates another embodiment of a vesicle 600 that is functionally similar to that of FIG. 5A but includes a plurality of chambers 620, 621 separated by a seal 622. FIG. 6B is a cross-sectional view of the vesicle shown in FIG. 6A taken along line AA, to include topical compositions 670, 671, each headspace 680, 681 as shown in FIG. 6B. It includes. Each chamber 620, 621 may comprise the same, similar or different topical composition (s). The seal 622 and the peripheral seal 660 separating the chambers 620, 621 may be designed to rupture sequentially or simultaneously depending on the peel force and the manner in which pressure or compression is applied by the user. .

A vesicle, such as the vesicle shown in FIG. 6A with multiple chambers, can also be designed for mixing of incompatible topical compositions. This allows the vesicles to deliver a number of effects, such as cleansing from one chamber and moisturizing from another chamber. Allow the chamber containing the detergent to dispense first to clean the hair, nails, face, hands, or body and the second chamber containing the moisturizer to dispense next to deepen the hair, nails, face, hands or body. ) Moisturizing is possible.

Alternatively, reactions such as foaming or further self heating may be achieved by dispensing two topical compositions from the vesicles that react when mixed during dispensing. For example, a double compartment vesicle may have one chamber containing sodium bicarbonate and another chamber containing a water based detergent such that when the two components meet they produce a foamable topical composition.

As an alternative to vesicles, including incompatible products, the vesicles may also include a single product that requires combining the components just prior to application due to the instability of the components when mixed. In such instances, these components may be separated into a plurality of vesicle chambers. The rupturable seal that separates these chambers can be collapsed by the user to allow the composition to mix freshly just prior to application.

FIG. 7A illustrates a vesicle embodiment 700 having two compartments 723, 724, with seal 725 dividing compartment 723 and compartment 724 at a vertical midline. The vesicles have tear tabs 710 that are removed at the perforation line 740. Topical compositions included in compartments 723 and 724 may be mixed upon discharge from the vesicles. 7B and 7C also show vesicle 700.

Although an amount sufficient for multiple uses of the composition may be included in the vesicles disclosed herein, in one embodiment, the vesicles are designed for single use, ie in unit doses. Since the unit dose may be applied to the entire keratinous surface of the user, for example the entire skin, hair or nail surface, or may be spot applied, the unit dose may vary from 0.1 grams to 30 grams. The periphery or seal of the vesicle may create a dispensing outlet to allow more precise control when the topical composition is dispensed. This allows for more accurate dispensing, but can also be used to require reasonable dispensing power before the product can be dispensed. By narrowing the outlet, the product may not leak from the reservoir unless the user exerts significant force on the reservoir as desired by the user for dispensing the product.

In some variations a vesicle that is opened before heating may be used, but the vesicle will generally remain sealed during heating, which may cause topical compositions or active ingredients in such compositions to be subjected to air, oxygen, light and / or microorganisms. This is because the quality may be degraded. Advantages of the present invention using vesicles include minimizing exposure of the composition to such deterioration conditions by application to keratinous tissue and the nature of the vesicles to be volume defined before and after heating. This enhances the efficacy of the composition and / or its active ingredient, which may have been avoided in the past due to its sensitivity to degradation. A further effect on the heating of the sealed vesicles is that the outflow into this device is eliminated. Not only are the messes reduced, but because the device typically has some electronic aspects, the introduction of the liquid product into the product causing malfunction of the components is minimized.

In addition, preventing the product from contacting atmospheric gases improves the stability of the topical composition. Thus, it is also possible to produce vesicles having a defined upper space or no upper space and / or comprising non-oxidizing gases other than air, for example nitrogen.

In some embodiments the vesicles may be flexible, while in others the vesicles are rigid. When placed in a suitably shaped receptacle, the flexible vesicles deform around a heat sink in the receptacle to maximize the efficiency of heat transfer to the vesicles and ultimately to their contents. In addition, the flexible vesicles can be easily dispensed by squeezing the contents into the hand. Rigid blister packs with a flexible film back cover may provide a disk that allows the finger to soak in the product after the back cover sheet is removed.

Heat transfer to and from the vesicle and its contents is important during heating and during use, since this heat transfer determines how quickly the vesicle and its contents warm and cool. Since heat transfer to the topical composition in the vesicles is a function of the heat resistance of the materials that make up the vesicles, by carefully selecting the vesicle surface material the composition in the vesicles can be heated in the desired time frame and keratinous tissue It can be maintained at the desired temperature in the receptacle for immediate use in the bed. For example, by increasing the thickness of the vesicle surface, the thermal resistance of that surface is increased. Higher thermal resistance reduces the rate of heat transfer to the composition through the surface. The vesicles with thicker surfaces will then take longer to warm the composition to a certain temperature, but will keep the composition warm for a longer period of time. Thermal resistance is also affected by the thermal conductivity of the material. Higher thermal conductivity materials can be used to reduce the thermal resistance of the surface. Materials with lower thermal conductivity can be used to make surfaces with higher thermal resistance. In addition, the heat transfer area affects the thermal resistance of the vesicle surface. As this area increases, the thermal resistance decreases. The larger heat transfer area reduces the heating and cooling time of the vesicles.

Combinations of materials that make up the same vesicles are also contemplated. For example, the thermal resistance of one surface of the vesicle may be higher. This will reduce the heat lost to the user's fingers while the user is holding the vesicles. This surface does not feel warm to the touch. Choosing a material with higher thermal conductivity, such as foil instead of plastic, reduces the thermal resistance. The foil vesicles heat up more quickly, but also cool down more quickly. Another means of reducing the thermal resistance is to increase the heat transfer area. Therefore, the combination of materials provides a thermal insulating surface, but a surface with low thermal resistance allows it to warm more rapidly.

The vesicles may comprise one or more surfaces coated or surrounded by volatiles. When the vesicles heat up, volatiles, such as fragrances, scent the surrounding air.

Substances that change color or opacity when the topical composition is warmed may optionally be used on the surface of the vesicles. This produces a visible signal based on the surface of the vesicle.

One embodiment of the vesicles comprises a solid comprising powder, beads, minerals and the like. In further embodiments, one of the vesicle surfaces may comprise an applicator for topical compositions. For example, the surface to be used as an applicator may include a portion that is a sponge like material. This sponge like portion will ensure that the topical composition is evenly applied to the user's keratinous tissue. Alternatively, the applicator may take the form of a brush, dropper or syringe.

In another embodiment, the vesicles comprise a topical composition in combination with a substrate for carrying out cleaning, treatment or other uses. In a preferred embodiment, the composition is pre-combined with a substrate or small paper towel to form a wipe product, for example a disposable wipe product, to be used later for that purpose. In a preferred embodiment, the wipe product comprises a nonwoven substrate impregnated with a topical composition inside the vesicle.

The vesicles are pouches, packets, cells, blisters, thermoformed cups, capsules, ampoules, boxed, conical, ballooned, bellows shapes, flexible or rigid pouches with multiple sides, syringes, droppers or It may also be made in a variety of shapes, including but not limited to vials. The vesicles can be flat, rounded, or a combination thereof.

Receptacle

The receptacle comprising the heating system includes a cavity for releasably receiving the vesicles. The heating system used in the present invention includes a heating element connected with the cavity wall. Alternatively, the heating element can be connected with a plurality of cavity walls. For example, in embodiments of the invention where multiple vesicles are heated simultaneously, the heating element may extend from the cavity wall adjacent to the power source, laterally along the walls of the cavity or fully around the entire inner surface of the receptacle. have. In alternative embodiments, the heating element and / or heat sink may be located in the center of the cavity such that the vesicles can be placed on each side and heated simultaneously.

In one embodiment, the heating system is operated by a manual switch. In another embodiment, the heating system is activated upon insertion of the vesicle into the cavity of the receptacle, thereby engaging a switch in communication with the interior wall of the cavity. The area of vesicle that engages the switch is called the "contact point". 8A shows an embodiment 800 of a vesicle with a contact point 890 designed to operate the heating system by a switch located at the base of the cavity in some embodiments of the receptacle. 8B and 8C are side and perspective views, respectively, of the vesicle 800, both of which also show a contact point 890.

Other optional components contemplated for use in the heating system disclosed herein include a heat sink in communication with the heating element, and a temperature sensor in selective communication with the heat sink. Optionally, a thermal breaker or fuse can be used between the heating element and the power source. Indicators, including visual feedback mechanisms, auditory feedback mechanisms, tactile feedback mechanisms, and combinations thereof, can be operatively associated with temperature sensors, monitors, and combinations thereof. The monitor can be used to control all functions of the heating system, including indicators. The monitor may include a microprocessor, microcontroller, timer or sensor, and other elements.

In a further embodiment, the heating system is activated upon insertion of the vesicles with one or more protrusions on the outer surface. The protrusion provides communication with a switch located on the wall of the cavity. The protrusions provide a "lock key function" to avoid accidentally turning on the heating system by insertion of an external object into the device, so that such objects do not melt or the receptacle is destroyed. In another embodiment, the sensor of the receptacle wall recognizes the presence of the vesicles and activates the heating element. When the vesicles are removed, the heating element stops working and the receptacle stops providing warmth. The sensor may be based on a change in resistance, capacitance, inductance, light transmittance, force, pressure, voltage, current, or other means when the vesicle is present, as opposed to when the vesicle is not present. For example, a photodiode that receives light from a light emitting diode (LED) may be covered by a vesicle so that an output signal of the photodiode may be changed. This change in light intensity can be used to control the heater. The vesicles with suitable characteristics to change the desired sensor signal can provide a lock key function.

The warming of the topical composition to its target temperature occurs within about 30 seconds to about 5 minutes, preferably about 30 seconds to about 2 minutes. The target temperature of the composition is about 30 ° C. to about 65 ° C., preferably about 35 ° C. to about 65 ° C., more preferably about 37 ° C. to about 60 ° C., and most preferably about 40 ° C. to about 55 ° C.

In an alternative embodiment, the heating system maintains the target temperature of the composition for a length of time. This length of time is about 1 minute to about 1 hour, preferably about 3 minutes to about 30 minutes.

A heat sink in contact with the heating element may optionally be used to transfer and distribute the heat generated by the heating element. The temperature sensor may be in communication with the heat sink, and the monitor may be in communication with the temperature sensor. When the temperature sensor generates a signal that the temperature of the heat sink is above its operating temperature for a specified period of time, the monitor cools the heat sink by adjusting or interrupting power to the heat sink, thereby reducing the temperature of the composition in the vesicles. Can be lowered within the desired temperature range. This interruption of power delivery to the heating element can function as a thermostat, safety feature and power saving feature. If the vesicles are heated for a certain length of time at a particular temperature without removal of the vesicles, the heating is stopped until the vesicles are removed and replaced or until the heating element is operated in some other way. On the other hand, if the temperature sensor generates a signal that the temperature of the heat sink is below its operating temperature, the monitor will adjust the power of the heat sink to raise the heat, thereby raising the temperature of the composition in the vesicle to the desired range. Can be.

Preferred heating elements for use in the present invention disclosed herein are electric resistance heaters. Examples include carbon / silver inks printed on resistive alloy wires or foils, thermally conductive plastics, polyesters or other flexible materials, etched foil heaters, positive temperature coefficient (PTC) heaters (ceramic stones), thick Film heaters, or electrical components that generate heat due to electrical resistance versus current flow are included.

Certain types of resistive alloy wire or foil type electrical resistance heaters that may be selected include rope / wire elements in metal tubes, rope / wire elements insert molded into heater assemblies, wire wound heaters, LCD heaters, and There is a ceramic fiber insulated wire heater.

Other heater types suitable for use in the present invention disclosed herein include Peltier junction heaters, microwave emitters, radiant heating elements, incandescent bulbs and heating lamps.

Chemicals that exothermic when combined can also be used to generate the heat required to warm the composition. Examples include heat of hydration reaction, heat of anhydrous reaction, heat of solution and neutralization reaction, heat of oxidation reaction, heat of crystallization reaction, heat by electrochemical heating, heat of phase change material, heat of condensation, and the like.

The power itself may be supplied by a variety of sources: AC or DC mains, cells, solar energy, flammable gases, chemical reactions, or any combination thereof. Combustible gases useful in the present invention include those known for use in portable butane-fired hair curling devices.

In a further variant, the receptacle includes an indicator, the indicator being operatively connected with a temperature sensor, monitor or timer. The indicator generates a signal when the topical composition reaches its target temperature or reaches the end of a predetermined period. The indicator may signal "heating", "warm", "ready", "keep", "on", or "off". The signal given by the indicator may be a visual signal, a voice signal or a combination thereof.

The choice of material and thermal resistance of the receptacle also affects the performance of the receptacle. For example, a heat sink, if present, will have a low thermal resistance and should store minimal heat if this is to quickly heat up the vesicles. The wall of the receptacle cavity should be made of a material rated for the required temperature and voltage that the receptacle may experience. Underwriters' Laboratories Inc. offers grades of these materials. In addition to the required UL material grades, the thermal resistance of the walls of the receptacle cavity can be higher to prevent heat loss to the surrounding environment.

Heat sinks are commonly used in the receptacles disclosed herein, although some examples do not require this. For example, a flexible film heater made of carbon and silver printed on polyester can heat up the vesicles quickly and efficiently when it is placed in direct communication with the vesicles. Such heaters, produced by Conductive Technologies, Inc. of York, Pennsylvania, USA, are used for medical purposes to heat intravenous fluids to body temperature. In addition, this heating system is a static heater.

1A illustrates an embodiment of the receptacle 100 disclosed herein. The receptacle 100 shows the vesicle 101 in place inside the cavity 114 of the receptacle. In this example, the power is US home current (110-120 V) conducted through plug 113.

FIG. 1B shows a right side view of the embodiment of FIG. 1A with no vesicles placed. FIG. FIG. 1C is a top view of the receptacle of FIG. 1A showing the front housing 111, cavity 114, plug 113, and rear housing 115.

1D is an exploded view of FIG. 1A with no vesicles placed; The front housing 111 and rear housing 115 surround a printed circuit board 116 that includes a microcontroller. The microcontroller stores and executes software instructions that control all other components. The heating element 117 is operatively connected with the heat sink 118. In this embodiment, the switch 119 is pressed upon insertion of the vesicles to actuate the heating element 117. The inner plate 110 forms the back wall of the cavity 114 for receiving the vesicles. The vesicle rest 121 is mounted on the front surface of the inner plate 110. As discussed below, the light emitting diode (LED) 123 signals whether the receptacle 100 is in a ramping or holding mode. Item 122 is a silicone rubber insulator and protects the printed circuit board (PCB) from the heating element. Resistance temperature detectors (RTDs) 127 measure the temperature of the heating element or heat sink. Thermal cutoff (TCO) is not shown, but stops the flow of current to the heating element when the temperature measured by the TCO exceeds its rated operating temperature. In this embodiment, the TCO used for the apparatus has a UL rated functional temperature of 120 ° C. The item 119 mentioned above is a switch. The switch extends into the cavity 114 containing the vesicle. Upon insertion of the vesicles, the switch 119 is triggered to activate the heating element 117. Plug 113 connects heating element 117 to a current.

2A illustrates a second embodiment of the receptacle 200 disclosed herein. In this example, the receptacle includes the battery 233 shown in FIG. 2C. The front housing 211 of the receptacle 200 surrounds the front portion of the cavity 214.

FIG. 2B shows a right side view of the embodiment of FIG. 2A showing the rear housing 215 of the receptacle 200.

2C is a cross-sectional view of FIG. 2A taken along line A-A. The front housing 211 and the rear housing 215 surround the cavity 214 and the heating system (not shown).

FIG. 2D is a top view of the receptacle 200 of FIG. 2A.

2E shows the rear housing 215 of the receptacle 200. Item 250 is an opening in the rear housing that allows mounting of the receptacle through a suitable hanger.

3A illustrates a third embodiment of the receptacle disclosed herein. This receptacle 300 is designed to heat two follicles simultaneously. These vesicles may comprise the same or different topical compositions. Items 314a and 314b are two regions within the receptacle cavity for vesicle insertion.

3B is a top view further showing receptacle 300.

4A shows another embodiment in which the receptacle 400 is mounted for recharging on a docking station 431 that is connected to current through a plug 413. 4C is a cross-sectional view of the receptacle with the docking station, taken along line A-A of FIG. 4B, which is a plan view of the receptacle 400. This cross section shows a battery 433 that can be recharged while mounted on the docking station 431. This embodiment allows the use of a rechargeable battery, allowing the receptacle to be used remotely when the battery is fully charged. 4D shows a left side view further showing receptacle 400.

The heating cycle may optionally be carried out in two distinctive modes: the ramping mode when the vesicle and its contents are warmed and the holding mode. During the holding mode, the vesicles and their contents are maintained at a constant temperature. If the vesicles are removed at any time during the heating cycle, the heater will turn off.

Referring to FIG. 1 as an example, during a ramping mode, the RTD 127 shown in FIG. 1D measures the temperature at the junction of the heater and the heat sink. The microprocessor in the printed circuit board 116 calculates the temperature ramp rate of the heater so that the temperature of the vesicles and their contents becomes 50 ° C. in three minutes.

After the completion of the ramping mode, it enters the holding mode. During the holding mode, the temperature of the heater is set to 60 ° C. for 15 minutes. If the vesicles are not removed after 15 minutes, the heater is turned off. The user must remove and reinsert the vesicles when the receptacle resumes heating. If the vesicles need to be reinserted, the heating cycle will be repeated.

9A is a perspective view of a fifth embodiment of a receptacle 900 having two heating elements and two heat sinks, a front housing 911, a rear housing 915 and a plug 913. 9B is a front view of the receptacle 900 showing the front housing 911. 9C is a cross-sectional view of the receptacle 900 taken along line B-B in FIG. 9B. Items 917a and 917b are heating elements. Items 991a and 918b are heat sinks for adjacent heating elements.

Substances that change the color or opacity level when the topical composition is warmed may optionally be used in the receptacle. This results in a visible signal based on the receptacle.

Way

As noted above, the method of treating keratinous tissue comprises the step of warming the topical composition contained within the vesicles using a receptacle as the first step. The power source warms the composition inside the vesicles to a target temperature that is sufficient to supply sufficient energy to the heating system to facilitate application to keratinous tissue but is not fluid enough to flow from the surface when applied. Typically this temperature is about 30 ℃ To 65 ° C. The warmed composition is removed from the vesicles and applied to the keratinous tissue.

The topical composition can be applied over a long period of time. "Long term topical application" means continuous topical application of the composition over a long period of time, preferably for a period of at least about 1 week, more preferably a period of at least about 1 month, even more preferably at least about Continuous application for a period of 3 months, even more preferably a period of at least about 6 months, and more preferably a period of at least about 1 year. Typically, the application will be about once a day, but the application rate may vary from about once a week to up to three times a day.

hygiene

The skin care regimen using the receptacle described above operates by selecting a vesicle from a variety of vesicles, inserting the vesicles into a receptacle to releasably receive the vesicles, and operating a heating system operatively connected with the receptacle. It comprises the step of. The topical composition is then warmed up in the vesicles. After warming up, the vesicles are opened and the warmed composition is applied to the user's skin. Similar to the one outlined above, a long term application schedule of topical compositions can be used in skin care regimens.

All documents cited in the Detailed Description of the Invention are, in relevant part, incorporated herein by reference, and no citation of any document should be construed as an admission as prior art relating to the invention.

While specific embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Accordingly, all such changes and modifications that fall within the scope of the invention are intended to be included in the appended claims.

Claims (24)

As a treatment method of keratinous tissue, a) using a receptacle to warm the topical composition contained within the vesicle, wherein the receptacle is    i) a wall forming a cavity for releasably receiving one or more said vesicles,    ii) a heating system connected with one or more of said walls of said cavity, and    iii) a power source operatively connected with the heating system to supply sufficient energy to the heating system to warm the composition to a target temperature; b) applying the warmed topical composition to the keratinous tissue How to include. The composition of claim 1, wherein the composition comprises a releasing active agent; Anti-acne actives; Anti-wrinkle actives; Anti-atrophy actives; Antioxidants; Radical scavengers; Chelating agents; Flavonoids; Anti-inflammatory agents; Anti-cellulite agents; Tanning actives; Skin whitening agents; Antimicrobial and antifungal actives; Sunscreen actives; Conditioning agents; Water soluble vitamins; Particulate matter; Sugar amines; Vitamin B3 compounds; Retinoids; Peptides; Phytosterols; Hexamidine and its derivatives; Dialkanoyl hydroxyproline compounds; Salicylic acid compounds; n-acyl amino acid compounds; Dehydroacetic acid, isomers, salts and derivatives thereof; A method comprising at least one active ingredient selected from the group consisting of skin firming agents and mixtures thereof. 4. The method of claim 2 or 3, wherein the viscosity of the topical composition is 10 to 500 Pa.s (10,000 to 500,000 cps) at its target temperature. The method according to any one of the preceding claims, wherein upon heating of the composition the viscosity persists within 20% of the viscosity before warming. The method of claim 1, wherein the composition is a solid at ambient temperature. The method of claim 1, wherein the topical composition contains a water-in-oil emulsion. The method of claim 1, wherein the topical composition contains at least 1% waxy material. A receptacle for warming a topical composition contained in a vesicle, i) a wall forming a cavity for releasably receiving one or more vesicles; ii) a heating system connected to one or more of said walls of said cavity and having the ability to achieve and maintain a target temperature of a topical composition; iii) a power source operably connected to the heating system for supplying energy to the heating system. Receptacle comprising a. 9. The receptacle of claim 8 wherein said heating system is controlled by a monitor. 10. The receptacle of claim 8 or 9 wherein the receptacle further comprises an indicator, the indicator being operatively connected with the monitor to generate a signal at the target temperature. 11. The apparatus of any of claims 8 to 10, wherein the receptacle further comprises a temperature sensor operatively connected to the indicator, wherein the indicator is in combination with a visual signal, a voice signal and a tactile signal at the target temperature. Receptacle for generating a signal selected from the group consisting of. The receptacle of claim 8 wherein the heating system is activated by insertion of the vesicles into the cavity. The receptacle of claim 8 wherein the heating system is operated by a manual switch. The receptacle according to any one of claims 8 to 13 wherein the heating system warms the topical composition to its target temperature within 30 seconds to 5 minutes. The receptacle of claim 8 wherein the heating system maintains the target temperature of the composition for a period of time. The method of claim 8, wherein the heating system is a) a heating element connected with said cavity wall adjacent said power source; b) a heat sink operatively connected with said heating element; c) a temperature sensor in communication with the heat sink; d) a monitor in communication with said temperature sensor, capable of interrupting energy transfer from said power source to said heating element for a predetermined period Receptacle comprising a. The receptacle of claim 8 wherein the power source is supplied by an AC / DC domestic current, a cell, solar energy, flammable gas, a chemical reaction, and any combination thereof. 18. The receptacle of any of claims 8 to 17 further comprising a timer. 18. The device of any one of claims 8 to 17, wherein the receptacle comprises an element selected from the group consisting of sensors, switches and combinations thereof located on the wall of the cavity, the element on the surface of the vesicles. Receptacle capable of communicating with one or more protrusions or contact points. As a kit for treating keratinous tissue, a) at least one topical composition containing at least one active ingredient; a) at least one vesicle comprising a surface forming at least one chamber for containing said composition; ii) the receptacle according to any one of claims 8 to 19. Kit comprising a. 21. The kit of claim 20, wherein said vesicles comprise a unit dose of said topical composition. 22. The kit of claim 20 or 21, wherein said vesicles comprise 0.5 ml to 5 ml of said topical composition. 23. The apparatus of claim 20, wherein the heating system comprises a heating element connected to the cavity wall and a heat sink operatively connected to the heating element, wherein the vesicles are inserted into the receptacle when the heating element is inserted into the receptacle. Kits that deform around the heat sink. As a skin care regimen, a) selecting the vesicles from the various vesicles, wherein the vesicles comprise at least one chamber containing a skin care composition; b) inserting the vesicles into the receptacle according to any one of claims 8 to 19; c) operating the heating system to warm the composition contained in the vesicles; d) opening the vesicles after they are warmed up; e) applying the heated composition to the keratinous tissue of the user at least once daily Regimen comprising a.

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