CN101175468A - Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate - Google Patents
Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate Download PDFInfo
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Abstract
The present invention provides personal care compositions containing tetrahydrocurcumin alone, or in combination with tetrahydromethoxycurcumin and/or tetrahydrobisdemethoxycurcumin. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.
Description
Technical field
The present invention relates to comprise the personal care composition of Aden's perfume base malonic acid ethylhexyl.Described compositions can be used for regulating the mammiferous keratinous tissue conditions of the above-mentioned processing of needs, especially can be used for prevention, postpones and/or treat the uneven colour of skin, for example as desalinating skin or reducing Pigmented cosmetic agent.
Background of invention
Consumer at present obtainable many personal care products is intended to improve collenchyme such as skin, hair and refer to/health and the physical appearance of toenail.In these products, the overwhelming majority relates to delay, minimize or even eliminate a crease in the skin and the histology changes, described variations is typical relevant to the infringement of human skin with skin aging or environment.Yet, still need cosmetic agent by being used as the desalination skin or reducing Pigmented cosmetic agent and prevent, postpone and/or handle the uneven colour of skin.
Mammiferous collenchyme, especially Ren Lei skin and hair are subjected to the infringement of many external and intrinsic factor.Above-mentioned extrinsic factor comprises ultraviolet radiation, environmental pollution, wind, Exposure to Sunlight, infrared radiation, low humidity, deleterious surfactant, grinding agent etc.On the other hand, intrinsic factor comprise that other biochemistry in chronological age and the skin changes.No matter be extrinsic factor or intrinsic factor, they all cause producing tangible skin injury sign.Typical skin injury comprises the thinning of skin of the Lock-in along with the increase at age.Along with above-mentioned thinning of skin, cell and the blood vessel of supplying with skin are reducing, and in addition, corium-epidermis junction is smooth day by day, and this causes the mechanical of this junction to die down." The Aging of Skin:Chronoaging Versus Photoaging " (the 3rd to page 4, nineteen ninety for Photodermatol.Photoimmunol.Photomed., the 7th volume) referring to for example Oikarinen.Visible other damage or variation comprise microgroove, corrugate on the aging or damaged skin, hyperpigmentation, sallow, sagging, black eye, swollen eye, pore increase, renewal rate slows down and abnormal desquamation or decortication.Other damage that causes owing to extrinsic factor and intrinsic factor comprises tangible dead bark (be exfoliation, peel off, coarse).For hair, except other problem, these extrinsic factor and intrinsic factor also can cause bleaching hair, hair bifurcated, slim and frahile, coarse, trichomadesis, hair growth speed to slow down etc.Therefore, need to try hard to improve the product and the method for these keratinous tissue conditions.
The preferred embodiment general introduction
The applicant finds that the personal care composition that comprises some skin and hair-care active substance can be used for providing preventative and therapeutic treatment to keratinous tissue conditions, especially desalinates skin and handles.According to an embodiment preferred of the present invention, a kind of personal care composition now is provided, described compositions comprises Aden's perfume base malonic acid ethylhexyl; At least a additional skin and/or hair-care active substance; And dermatological acceptable carrier.Described active substance is selected from the group of being made up of following material: tetrahydrocurcumin; osamine; peptide; plant sterol; two alkanoyl hydroxyprolines; the primoline chemical compound; cetylpyridinium chloride; N-acyl amino acid compound; hesperetin; the Semen Brassicae Junceae extract; glycyrrhizic acid; enoxolone; ergothioneine; melanonostatin; sterol ester; idebenone; dehydroactic acid; licochalcone A; creatine; kreatinin; the Radix Agrimoniae extract; yeast extract; beta glucan; alpha-glucans; their salt; their derivant; their precursor; and/or their combination.In one embodiment, described personal care composition is not as sunscreen product commercially available (although it can comprise sunscreen actives).
The invention still further relates to article of commerce, described article of commerce comprises personal care composition as disclosed herein.According to an embodiment preferred, now also provide a kind of article of commerce, described article of commerce comprises the personal care composition that comprises Aden's perfume base malonic acid ethylhexyl; At least a packing that is used for described personal care composition; And the show and colour relevant with described personal care composition.Described show and colour comprises labelling and/or image, and described labelling and/or image are passed on following information: described personal care composition can be united the situation that is used for regulating mammiferous collenchyme that makes with the energy delivery apparatus.
The invention still further relates to the method for regulating mammiferous keratinous tissue conditions, wherein each method comprises the step to the personal care composition of the present invention of the safe and effective amount of mammiferous collenchyme local application of the above-mentioned processing of needs.According to an embodiment preferred, a kind of method now is provided, and described method comprises to organizing the desired zone local application to comprise the personal care composition of Aden's perfume base malonic acid ethylhexyl and subsequently to the step of organizing desired zone to use to comprise second personal care composition of sunscreen actives.
According to another embodiment preferred, a kind of method now is provided, and described method comprises to organizing the desired zone local application to comprise the personal care composition of Aden's perfume base malonic acid ethylhexyl and applying the step of energy via the energy delivery apparatus to tissue regions.
Illustrative and embodiment preferred describes in detail
Except as otherwise noted, all percentage ratios used herein and ratio are all by the weight of total composition, and all measurements are all carried out at 25 ℃.
Compositions of the present invention can comprise, basically by or be grouped into by solvent described herein and nonessential one-tenth.Used herein " basically by ... form " be meant that described compositions or component can comprise supplementary element, as long as described supplementary element can not change the new characteristic of fundamental sum of claimed compositions of the present invention or method in itself.
Term used herein " collenchyme " is meant the horny layer that contains as mammal outermost layer guard cover, and it includes but not limited to skin, hair, toenail, fingernail, epidermis, hoof etc.
Term used herein " local application " is meant compositions coating of the present invention or is coated on the surface of collenchyme.
Term used herein " dermatological is acceptable " is meant that described compositions or component are applicable to human collenchyme and contacts, and do not have unsuitable toxicity, incompatibility, unstability, atopic reaction etc.
Term used herein " safe and effective amount " is meant that the amount of chemical compound or compositions is enough to significantly produce positive beneficial effect, preferred positive collenchyme outward appearance or the sensation beneficial effect of producing, this beneficial effect comprises beneficial effect independently disclosed herein or combination, but this amount is enough low again to avoid serious adverse (promptly, in the rational determination range of technical staff, provide rational effect danger than).
Term used herein " hyperpigmentation after the inflammation " be meant because of the inflammation incident (as acne, scratch, insecticide sting or sting, Exposure to Sunlight etc.) variation of the melanin content that reflects, especially obvious to the experimenter of dark skin.
Term used herein " hyperpigmentation " is meant that wherein pigmentation is greater than the Pigmented skin area of skin adjacent domain (as eyespot, senile plaque etc.).
Term used herein " desquamation, decortication and/or renewal " is meant the outer layer of stratum corneum removal of (comprising horny layer).
Term used herein " oiliness and/or glossy appearance " is meant that the mammal skin with smooth appearance is tending towards demonstrating oils and fats, sebum and/or the perspiration from separately glandular secretion.
Term used herein " sagging " is meant the situation such as lax, sagging of skin, and described situation is by the proteic loss of skin elasticity, destruction, change and/or unusual the generation.
Term used herein " smooth " and " softening " are meant that the surface that changes collenchyme is to improve sense of touch.
Term used herein " sallow " is meant the protein glycation effect that together takes place owing to for example typical case and skin aging and lipofuscin gathers or peripheral blood flow minimizing effect, because of the loss of skin component, destruction, change and/or unusual so that situations such as the skin color that their variable colors (for example color jaundice) produce is greyish white, jaundice.
Compositions of the present invention can be used for local application, and can be used for regulating keratinous tissue conditions.Because intrinsic factor and/or extrinsic factor can bring out or cause the various situations of health, therefore usually need be, especially the human skin situation is regulated to keratinous tissue conditions.For example, " adjusting skin " comprises preventative adjusting and/or therapeutic regulation, and can comprise following one or more beneficial effects: thicken and (promptly construct epidermal area and/or skin corium and/or hypodermic layer such as the fat and the muscle of skin, and under suitable situation, structure refers to/horny layer of toenail and hair shaft) to reduce atrophy (as the atrophy of skin), increase curling of corium-epidermis border, plain dyschromasia of non-black such as eye pouch, the rash speckle (for example, by the inhomogeneous redness that causes as acne erythematosa) (hereinafter being referred to as erythema), sallow (canescence or yellow), the variable color that causes by telangiectasis or spider shape blood vessel, by melanin (as eyespot, senile plaque, inhomogeneous pigment calmness) (the lipofuscin for example of other chromophore and in the skin, protein cross those as occurring with saccharification, or the like) variable color that causes.Preventative adjusting used herein comprises delay, minimizes and/or prevents visible and/or palp skin discontinuity (for example, appreciable in irregular texture, microgroove, wrinkle, sagging, stretching vestige, honeycomb inflammation, swollen eye or the like skin or feel).Therapeutic regulation used herein comprises the discontinuity of improving (for example reduce, farthest reduce and/or eliminate) skin.Regulating skin comprises and improves skin appearance and/or sensation.
Term used herein " adjusting skin " is intended to comprise the adjusting of these signs, and no matter the mechanism of the origin cause of formation.
The compositions of the present invention that comprises solvent and optional component thereof will be explained below.
Personal care composition
Component
Compositions of the present invention can comprise Aden's perfume base malonic acid ethylhexyl of safe and effective amount.The content of Aden's perfume base malonic acid ethylhexyl is preferably about 0.01% to about 20% by the weight of described compositions, and more preferably from about 0.1% to about 15%, even more preferably from about 0.5% to about 10%.
Preferred Aden perfume base malonic acid ethylhexyl is Oxynex ST
, its demonstration has antioxidant properties.It can be available from Rona/Merck.
Additional skin and/or hair-care active substance
Compositions typical case of the present invention comprises at least a additional skin and/or the hair-care active substance of safe and effective amount.The unrestricted exemplary lists of above-mentioned active substance comprises osamine, vitamin B
3Retinoid; hydroquinone; peptide; farnesol; plant sterol; two alkanoyl hydroxyprolines; primoline; salicylic acid; N-acyl amino acid compound; sunscreen actives; water soluble vitamins; fat soluble vitamin; hesperetin; the Semen Brassicae Junceae extract; glycyrrhizic acid; enoxolone; carnosine; Yoshinox BHT (BHT) and butylated hydroxyanisol (BHA); Antisolaire; cetylpyridinium chloride; tetrahydrocurcumin; the vanillin or derivatives thereof; ergothioneine; melanonostatin; sterol ester; idebenone; dehydroactic acid; yeast extract is (as Pitera
), beta glucan, alpha-glucans, fatty acid (especially polyunsaturated fatty acid), 1-oxygen-2-mercaptopyridine zinc (ZPT), antifungal, mercaptan compound (as N-acetylcysteine, glutathion, thioglycol acid esters), other vitamin (vitamin B12), beta-carotene, ubiquinone, aminoacid, their salt, their derivant, their precursor and/or their combination.A part of further describing in these additional activity materials hereinafter is provided.
Skin of the present invention and/or hair-care active substance can be used for desalinating skin.The desalination skin can take place by number of mechanisms, comprises antioxidant mechanism, trypsin inhibitory action, antiinflammatory mechanism, nitric oxide scavenging action, tyrosinase inhibitory action etc.Therefore, exist these machine-processed chemical compounds to have the probability of desalination skin.
1. tetrahydrocurcumin
Compositions of the present invention can comprise tetrahydrocurcumin (THC), its derivant such as ester or the ether and their combination of safe and effective amount.When existing, described compositions comprises by the weight of described compositions preferred about 0.01% to about 10%, and more preferably from about 0.1% to about 5%, even 0.2% to about 3% curcuminoid chemical compound more preferably from about.
Because many stimulations as contact ultraviolet and stimulus object, and cause producing oxygen-derived free radicals in skin.Above-mentioned free radical also can be used as ordinary cells or anabolic by-product and produces.Oxygen-derived free radicals can stimulate pigment cell's (melanocyte) to increase the generation of melanocyte.Curcuminoid (as THC) has antioxidant properties, thereby can before oxygen-derived free radicals stimulates melanocyte they be removed.
The protein-tyrosine enzyme is that amino acid tyrosine is transformed into DOPA (Dihydroxyphenylalanine), further is transformed into other intermediate then and is aggregated to enzyme related in the dermal melanin process.The inhibition partially or completely of tryrosinase is delayed or stoped the formation of melanocyte respectively, produce the brighter colour of skin (for example, having reduced the degree of depth of hyperpigmentation speckle).Curcuminoid (as THC) but also restraint of tyrosinase.
Other curcuminoid that can be used among the present invention comprises curcumin, tetrahydrochysene demethoxycurcumin, tetrahydrochysene bisdemethoxycurcumin, their derivant such as ester and ether and their combination.Curcuminoid (as THC) can have natural or synthetic source.Preferably, in the present invention, tetrahydrocurcumin can use separately, or unites use with the tetrahydrochysene demethoxycurcumin, and/or unites use with the tetrahydrochysene bisdemethoxycurcumin.Preferred derivant is an ester, especially tetrahydrocurcumin diacetate esters, and/or the combination of itself and tetrahydrocurcumin, and/or the combination of itself and tetrahydrochysene demethoxycurcumin, and/or the combination of itself and tetrahydrochysene bisdemethoxycurcumin, and/or the combination of itself and ester, especially tetrahydrochysene demethoxycurcumin diacetate esters, and/or tetrahydrochysene bisdemethoxycurcumin diacetate esters.
2. osamine (amino sugar)
Compositions of the present invention can comprise the osamine of safe and effective amount, and it is also referred to as amino sugar.The osamine chemical compound that can be used among the present invention is described in PCT announcement WO 02/076423 and the United States Patent (USP) 6,159,485.
When existing, described compositions comprises by the weight of described compositions preferred about 0.01% to about 15%, and more preferably from about 0.1% to about 10%, even 0.5% to about 5% osamine more preferably from about.
Osamine derives from synthetic or natural, and the mixture (for example being derived from the natural extract or the mixture of synthetic) that can be used as pure compound or chemical compound uses.Glycosamine is present in many Crustaceans and also usually can derive from fungal source.Term used herein " osamine " comprises the isomer and the tautomer of above-mentioned substance and salt (as HCl salt) thereof, and can be commercially available from SigmaChemical Co..
The example that can be used for osamine of the present invention comprises glycosamine, N-acetyl glucosamine, glucosamine sulfate, mannosamine, N-acetylmannosamine, galactosamine, N-acetyl group galactosamine, their isomer (as stereoisomer) and their salt (as HCl salt).What preferably can be used for this paper is glycosamine, especially D-glycosamine and N-acetyl glucosamine, especially N-acetyl group-D-glycosamine.
3. peptide
Compositions of the present invention can comprise the peptide of safe and effective amount, includes but not limited to dipeptides, tripeptides, tetrapeptide, pentapeptide and six peptides and their derivant.When existing, described compositions comprises by the weight of described compositions preferred about 0.000001% to about 20%, and more preferably from about 0.000001% to about 10%, even 0.00001% to about 5% peptide more preferably from about.
Term used herein " peptide " is meant and comprises ten or still less amino acid whose peptide and their derivant, isomer, and with the coordination compound of other material such as metal ion (for example, copper, zinc, manganese, magnesium etc.).Peptide used herein not only refers to naturally occurring peptide but also refer to synthetic peptide.Also can be used for of the present invention is the naturally occurring and commercially available peptide combinations that contains.Preferred peptide is the lipophilic derivatives of dipeptides carnosine (Beta-alanine-histidine), tripeptides (glycine-histidine-lysine), pentapeptide (lysine-threonine-threonine-lysine-serine), peptide, and above-mentioned metal complex, as the copper complex of tripeptides (HIS-GLY-glycine) (being also referred to as Iamin).Preferred dipeptidase derivant is palmityl-lysine-threonine.The commercial composite that preferably comprises tripeptide derivative is Biopeptide CL
, it comprises palmityl-glycine-histidine-lysine of 100ppm, and can be commercially available from Sederma.The commercial composite that preferably comprises pentapeptide derivative is Matrixyl
, it comprises palmityl-lysine-threonine-threonine-lysine-serine of 100ppm, and can be commercially available from Sederma.
4. primoline
Can be used for primoline chemical compound among the present invention corresponding to having those of following formula structure:
R wherein
1And R
2Comprise organic acid (as sulfonic acid etc.).
When existing, the content of described primoline is preferably about 0.0001 to about 25% by the weight of described compositions, and more preferably from about 0.001 to about 10%, and more preferably from about 0.01 to about 5%, even more preferably from about 0.02 to about 2.5%.
Topical compositions of the present invention can nonessentially comprise one or more primoline chemical compounds of safe and effective amount, its salt and its derivant.Primoline derivant used herein comprises all isomers and the tautomer of primoline chemical compound, includes but not limited to organic acid and mineral acid, for example sulfonic acid, carboxylic acid etc.Preferably, the primoline chemical compound comprises dihydroxy ethyl sulfonic acid primoline, and it can trade name Elestab
HP100 is commercially available from LaboratoiresSerobiologiques.
5. cetylpyridinium chloride
Compositions of the present invention can comprise the cetylpyridinium chloride (CPC) of safe and effective amount.The replacement form of hexadecylpyridinium chloride comprises quaternary compound, wherein one or two substituent carbon chain lengths (being typically alkyl) is about 8 to about 22 on the quaternary nitrogen, typical case about 10 is to about 18 carbon atoms, remain substituent group (being typically alkyl or benzyl) simultaneously and have carbon number still less, 1 to about 7 carbon atoms (being typically methyl or ethyl) according to appointment.These alkyl chains that substitute in the form can be straight or brancheds, and can be saturated or unsaturated.Dodecyl trimethyl ammonium chloride, TPC, the cetyl dimethyl benzyl ammonium chloride, chlorination 1-cetyl pyridinium, the dimethyl stearyl benzyl ammonium chloride, hexadecyltrimethylammonium chloride, cetyl trimethyl ammonium bromide, octadecyl trimethyl ammonium chloride, brominated phenododecinium bromide, chlorination N-myristyl-4-ethylpyridine, dodecyl dimethyl (2-phenoxy group ethyl) ammonium bromide, benzyl dimethyl stearyl chlorination ammonium, quaternized 5-amino-1,3-two (2-ethylhexyl)-5-methyl hexahydropyrimidine, alkyl benzyl dimethyl ammonium chloride, iso-octyl phenoxy group ethoxyethyl group benzyl dimethyl ammonium chloride and methyl iso-octyl phenoxy group ethoxyethyl group benzyl dimethyl ammonium chloride are the examples of typical quaternary ammonium reagent.Other chemical compound is two-4-(R-amino)-1-pyridine alkane, and it is disclosed in United States Patent (USP) 4,206, in 215.The electronegative counter ion counterionsl gegenions of these quaternary compounds are typically chloride ion or bromide ion, but alternatively are fluorion, iodide ion, inferior sulfate radical, sulfate radical, carbonate etc.
The content of cetylpyridinium chloride or other quaternary compound counts about 0.005% to about 10% by the weight of described compositions, and more preferably from about 0.01% to about 5%, and more preferably from about 0.05% to about 2%.A discovery that never reckons with is, cetylpyridinium chloride is the inhibitor of some enzyme related in the pigmentation process, as tryrosinase.It is believed that other quaternary compound except that the chlorination cetyl pyridinium also can suppress enzyme related in the pigmentation process.The protein-tyrosine enzyme is that amino acid tyrosine is transformed into DOPA (Dihydroxyphenylalanine), further is transformed into other intermediate then and is aggregated to enzyme related in the dermal melanin process.The inhibition partially or completely of tryrosinase is delayed or stoped the formation of melanocyte respectively, produce the brighter colour of skin (for example, having reduced the degree of depth of hyperpigmentation speckle).
6.N-amic acid chemical compound
Topical compositions of the present invention can comprise one or more N-amic acid chemical compounds of safe and effective amount.Described aminoacid can be any aminoacid known in the art.N-acyl amino acid compound of the present invention meets the following formula structure:
Wherein R can be the combination of hydrogen, alkyl (replace or unsubstituted, side chain or straight chain) or alkyl and aryl.Aminoacid known in the art may side chain tabulation be described among " Biochemistry " of the Stryer that announced by W.H.Freeman and Company in 1981.R
1Can be saturated or undersaturated, straight or branched, replacement or unsubstituted C
1To C
30Alkyl; Replace or unsubstituted aryl; Or their mixture.
N-amic acid chemical compound is preferably selected from N-acyl group phenylalanine, N-acyl group tyrosine, their isomer, their salt and their derivant.Aminoacid can be D or L isomer or their mixture.N-acyl group phenylalanine meets the following formula structure:
R wherein
1Can be C
1To C
30Saturated or undersaturated, straight or branched, replacement or unsubstituted alkyl; Replace or unsubstituted aromatic group or their mixture.
N-acyl group tyrosine meets the following formula structure:
R wherein
1Can be C
1To C
30Saturated or undersaturated, straight or branched, replacement or unsubstituted alkyl; Replace or unsubstituted aromatic group; Or their mixture.
What especially can be used as the cosmetic agent that makes local colour of skin unanimity (desalination skin or reduce pigmentation) is N-endecatylene acyl-L-phenylalanine.This reagent belongs to generalized N-acyl group Phenylalamine derivatives classification, and its acyl group is a C11 monounsaturated fatty acid part, and aminoacid is the L-isomer of phenylalanine.N-endecatylene acyl-L-phenylalanine meets the following formula structure:
N-endecatylene acyl group used herein-L-phenylalanine can trade name Sepiwhite
Commercially available from SEPPIC.
When existing, the content of N-acylamino acid is preferably about 0.0001% to about 25% by the weight of described compositions, and more preferably from about 0.001% to about 10%, and more preferably from about 0.01% to about 5%, even more preferably from about 0.02% to about 2.5%.
7. glycyrrhizic acid
Compositions of the present invention can comprise the glycyrrhizic acid of safe and effective amount and/or its salt.When existing, described compositions comprises weight by described compositions and is preferably about 0.01% to about 10%, and more preferably from about 0.05% to about 5%, even 0.1% to about 3% glycyrrhizic acid chemical compound more preferably from about.Glycyrrhizic acid is the component in the Radix Glycyrrhizae extract.
Glycyrrhizic acid is an antiinflammatory.Inflammatory mediators or cytokine can stimulate pigment cell's (melanocyte) to produce melanocyte.Therefore, inflammation situation such as ultraviolet injury, acne, ingrown hair, sting, scratch etc. will excite hyperpigmentation after the so-called inflammation.Though ultraviolet is the main inducer of all types cutaneous pigmentation, specifically, will promote the pigmentation of dark skin individuality (as Spaniard, Aisan) skin by the pigment of other inflammatory stimulus (acne etc.) generation.Will reduce pigmentation with the antiinflammatory inflammation-inhibiting.
It is believed that also glycyrrhizic acid is nitric oxide production scavenger.Nitric oxide (NO) is Pigmented stimulant.Use nitric oxide scavengers (reacting to stop it to stimulate chromatophorous material), will reduce pigmentation with nitric oxide.
Glycyrrhizic acid also is called as glycyrrhizin, glycyrrhizin or glycyrrhizin.
8. enoxolone
Compositions of the present invention can comprise the enoxolone of safe and effective amount and/or its salt.When existing, described compositions comprises weight by described compositions and is preferably about 0.01% to about 10%, and more preferably from about 0.05% to about 5%, even 0.1% to about 3% enoxolone chemical compound more preferably from about.Enoxolone is the component in the Radix Glycyrrhizae extract.
Enoxolone also is an antiinflammatory, is discussed in above in the glycyrrhizic acid part.Enoxolone structurally is different from glycyrrhizic acid, because enoxolone does not have the saccharide residue (glycoside) of connection.Enoxolone also is called as carbenoxolone, glycyrrhetinic acid or biosone.
9. ergothioneine
Compositions of the present invention can comprise the ergothioneine of safe and effective amount.The content of ergothioneine is preferably about 0.0001% to about 20% by the weight of described compositions, and more preferably from about 0.001% to about 5%, even more preferably from about 0.01% to about 1%.Preferred ergothioneine is Thiotaine
, it is the commercial solution of chemicals ergothioneine, can be commercially available from Barnet Products.
The dermatological acceptable carrier
Topical compositions of the present invention also can comprise the dermatological acceptable carrier that is used for active substance.Phrase used herein " dermatological acceptable carrier " is meant that carrier is suitable for being locally applied to collenchyme, has good aesthetic properties, with active substance of the present invention and any other component compatibility, and does not cause any safety or toxicity problem.The carrier of safe and effective amount account for described compositions about 50% to about 99.99%, preferred about 60% to about 99.9%, more preferably from about 70% to about 98%, even more preferably from about 80% to about 95%.
Carrier can take various forms.For example, emulsion carriers can be used for the present invention.Described emulsion carriers includes but not limited to O/w emulsion, water-in-oil emulsion, water-covered siloxane emulsion, water-in-silicone emulsion, water-in-oil-in-water compositions and water-in-silicone bag fat liquor.
Preferred carrier comprises emulsion, as O/w emulsion and water-in-oil emulsion, and for example water-covered siloxane emulsion or water-in-silicone emulsion.Such just as understood as technical staff, given component will mainly be assigned in water or the oil phase, and this depends on the water solublity/allocability of this component in compositions.Especially preferred O/w emulsion.
Generally comprise aforesaid solution and lipoid or oil according to emulsion of the present invention.Lipoid and oil can derive from animal, plant or oil, and can natural or synthetic (promptly manually making).Preferred emulsions also comprises wetting agent, for example glycerol.By the weight of described compositions, emulsion preferably also comprises about 0.1% to about 10%, more preferably from about 0.2% to about 5% emulsifying agent.Emulsifying agent can be nonionic, anion or cationic.Examples of suitable emulsifiers is disclosed in " Detergentsand Emulsifiers " North America version the 317th of for example United States Patent (USP) 3,755,560, United States Patent (USP) 4,421,769 and McCutcheon in the 324th page (1986).
According to required product type, suitable emulsion can have the very wide viscosity of scope.Preferred exemplary low viscosity emulsion has about 5E-5m
2/ s (50 centistoke) or lower, more preferably from about 1E-5m
2/ s (10 centistoke) or lower, even 5E-6m more preferably from about
2/ s (5 centistoke) or lower viscosity.
Compositions of the present invention also can comprise the acceptable topical vehicle of other dermatological and can comprise oral carrier.For example, another kind of topical vehicle can be the cleaning agent (for example, soap slab, shampoo, foamed cleanser, liquid cleaner, bath shampoo, cleaning towel etc.) that comprises surfactant.In above-mentioned carrier, surfactant can be anion, cation, amphion, nonionic, or these mixture.Another kind of topical vehicle is coloured cosmetics (lip pomade, kermes, informer, mascara, foundation creams, refer to/the toenail wet goods).A kind of oral carrier is beverage, food, pill, capsule, powder, capsule sheet etc.
Optional component
The present composition can comprise other composition commonly used in the multiple given product type, and precondition is that they can change beneficial effect of the present invention acceptably.
In the time of in being incorporated into compositions, optional component should be applicable to human collenchyme and contact reasonably do not having unsuitable toxicity, incompatibility, unstability, atopic reaction or the like in the determination range." CTFA Cosmetic Ingredient Handbook " second edition (1992) has been described multiple non-limiting beauty treatment and the ingredient that is generally used for the skin nursing field, and they are applicable in the compositions of the present invention.Other example of these constituent classes comprises: grinding agent, absorbent, beauty treatment component such as aromatic, pigment, stain/coloring agent, quintessence oil, anti-caking agent, defoamer, binding agent, bio-additive, buffer agent, extender, chelating agen, chemical addition agent, coloring agent, the cosmetics astringent, the cosmetics insecticide, denaturant, the medicine astringent, external-use analgesic, film former or the film forming matter polymer (as eicosylene and vinylpyrrolidone copolymers) of aid composition film forming characteristics and affinity (as be used for), opacifier, the pH regulator agent, propellant, Reducing agent, sequestering agent and thickening agent.
Compositions of the present invention also can comprise synthetic cationic polymer polyquaternary ammonium salt-37 (methacryl ethyl-trimethyl salmiac homopolymer).Described polymer also can be used as powder or liquid dispersion is added in the described compositions.This polymer is can commercial name commercially available from Synthalen (3VSigma), Ultragel 300 (Cosmetic Rheologies Ltd), RheocareCTH (E) (Cosmetic Rheologies Ltd.), Salcare SC95 and SalcareSC96 (Ciba Specialty Chemicals).
Other optional component that can be used among the present invention comprises that the U.S. announces those that describe among the 2004/0175347A1, comprises the desquamation active substance, as salicylic acid and zwitterionic surfactant; Console agent and/or rehabilitation agent; Skin treatment agents; The skin sensitizer; Astringent etc. (as Oleum Caryophylli, menthol, Camphora, Eucalyptus oil, acetaminol, menthyl lactate, Radix Hamamelidis Mollis distillate); The anti-acne active substance is as resorcinol, sulfur, erythromycin, zinc, dehydroactic acid; Anti-wrinkle active substance/anti-atrophy active substance; Antioxidant/free radical scavenger is as tocopherol; Chelating agen is as furil-dioxime and derivant thereof; Flavonoid; Antiinflammatory; The scorching agent of anti-cellulite; Tanned active substance is as dihydroxy acetone; Skin lightening agent; Antimicrobial and antifungus active substance; Sunscreen actives; Conditioner is as glycerol, carbamide, vaseline, Olestra and their combination; Thickening agent is as carboxylic acid polyalcohol, cross-linked polyacrylate polymer, polyacrylamide polymers, polysaccharide, natural gum; Water soluble vitamins; And particulate material.Compositions of the present invention can comprise following one or more other active substance or compositions of safe and effective amount: fatty acid (especially polyunsaturated fatty acid); glycosamine; 1-oxygen-2-mercaptopyridine zinc (ZPT); mercaptan compound is (as the N-acetylcysteine; glutathion; the thioglycol acid esters); other vitamin is (as B1; B2; B5; B6; B12; C; D; E; F; K; P); beta-carotene; ubiquinone; idebenone; aminoacid; mineral is (as Zn; Mn; Mg; Cu; Fe and Se); hydroxy acid is (as 'alpha '-hydroxy acids; 2-ketoacid and beta-hydroxy acid); kojic acid; arbutin; mulberry extract; decorticating agent; dandruff agent etc.
Composition forms
The topical compositions of this theme invention includes but not limited to lotion, emulsion, mousse, serosity, spray, aerosol, foam, club, lip pencil thing, gel, cream and ointment, and described compositions can comprise the acceptable emollient of dermatological.Above-mentioned composition preferably comprises about 2% to about 50% emollient." emollient " used herein is meant and is used to the material that prevents or alleviate drying and be used to protect skin.Known have multiple suitable emollient and can be used for herein.The 2nd edition the 1st volume of " Cosmetics, the Science and Technology " of the Sagarin mat woven of fine bamboo strips 32 has comprised many examples that are suitable for the material of making emollient in the 43rd page (1972).Preferred emollient is a glycerol.The consumption of glycerol is preferably about 0.001% to about 20% by the weight of described compositions, and more preferably from about 0.01% to about 15%, even more preferably from about 0.1% to about 10%.
The present composition that can be used for cleaning (" cleaning agent ") is with suitable carrier (for example, aforesaid carrier, and comprise dermatological acceptable surfactant by the weight of described compositions about 1% to about 90%) preparation.
The physical form of Cleasing compositions is unimportant.Described compositions can be configured to and for example wash one's hands and face soap slab, liquid, shampoo, bath gels, conditioner, hair oil, paste or mousse.The washing soap slab is preferred, because this is the cleaning agent form that is most commonly used to washed skin.Washing-off type Cleasing compositions such as shampoo need be suitable for active substance with capacity and be deposited on delivery system on skin and the scalp.Preferred delivery system relates to the undissolved complex of use.The more complete disclosure of above-mentioned delivery system is found in United States Patent (USP) 4,835, in 148.
The present composition also can be the cosmetics form.Suitable cosmetics form includes but not limited to foundation cream, lip pomade, kermes, mascara or the like.Above-mentioned cosmetics can comprise conventional composition, as oil, coloring agent, pigment, emollient, aromatic, wax, stabilizing agent etc.Be applicable to that the exemplary carrier of this paper and above-mentioned other composition for example are described in the United States Patent (USP) 6,060,547.
Compositions of the present invention can also be the formulation products form that shaves, and comprises example gel, foam, lotion and cream; And comprise aerosol and non-aerosol type.
Preparation of compositions
The present composition is usually by conventional method preparation, the method for preparing topical compositions as known in the art.The said method typical case relates to the state that composition is mixed to the comparison homogeneous in one or more steps, can need or not need conditions such as heating, cooling, use vacuum.The described compositions of preferred for preparation is so that active agent stability (physical stability, chemical stability, light stability) and/or send optimum.This optimization can comprise suitable pH value (as, less than 7), get rid of can be with active substance compound and thereby negative effect stability or substance for delivery (as despumation ferrum), use method (as suitable dispersant or double casing) that the prevention complex generates, use suitable light stability method (as adding suntan lotion/sunscreen cream, using opaque packing), or the like.
Regulate the method for keratinous tissue conditions
Compositions of the present invention can be used for regulating numerous mammiferous keratinous tissue conditions.The adjusting of above-mentioned keratinous tissue conditions comprises preventative and therapeutic regulation.More particularly, above-mentioned control method relates to but is not limited to thicken collenchyme (promptly construct epidermal area and/or the skin corium and/or the hypodermic layer of skin, and under suitable situation, structure refers to/horny layer of toenail and hair shaft); By being used as the desalination skin or reducing Pigmented enamel and prevent, postpone and/or handle the uneven colour of skin; Prevention, postpone and/or handle the atrophy of mammal skin, softening and/or level and smooth mammiferous lip, hair and refer to/toenail; Prevention, delay and/or processing mammal skin pruritus; The appearance of prevention, delay and/or processing black eye and/or swollen eye; Prevention, delay and/or processing mammal colour of skin sallow; Prevention, delay and/or processing mammal skin sagging (being saccharification); Prevention and/or postpone that mammal skin is tanned, desquamation, decortication and/or increase renewal in the mammal skin; Reduce the pore size in the mammal skin; Regulate oiliness/glossy mammal skin outward appearance; Hyperpigmentation after prevention, delay and/or processing hyperpigmentation such as the inflammation; The appearance of spider shape blood vessel and/or erythema on prevention, delay and/or the processing mammal skin; Prevention, delay and/or processing mammal skin microgroove and wrinkle; Prevention, postpone and/or handle xerosis cutis (promptly coarse, peel, peel off); And the appearance that prevents, postpones and/or handle honeycomb inflammation in the mammal skin.The present composition also can be used for hair growth inhibition, reduce the shaving frequency, improve the shaving easiness, reduce the shaving frequency, make hair more soft and/or more very thin, make that hair is more unshowy, the hair regeneration that slows down long, reduce erythema and scytitis, make skin more smooth and/or more soft and improve the hair removing mode.The adjusting keratinous tissue conditions relates to the present composition to the safe and effective amount of collenchyme local application.The amount of composition of being used, the frequency of using and life cycle will change widely according to skin in the given compositions and/or hair-care active substance and/or other components contents and required regulating degree.
In a preferred embodiment, described compositions is coated on skin for a long time." long-term local application " be meant the experimenter in life, topical composition constantly for a long time, and the preferred time is at least about a week, more preferably at least about one month, even more preferably at least about three months, even more preferably at least about six months, and even more preferably at least about 1 year.Although beneficial effect still can obtain after the various maximum operating period (for example five, ten or 20 years), preferably use whole all the continuing for a long time in life of experimenter.In the time of above-mentioned continuity, the typical case according to every day rule approximately once use, yet frequency of administration can be weekly approximately to every day three times approximately or change in the scope more frequently.
The various consumptions of the present composition can be used to provide the beneficial effect of skin appearance and/or dermal sensation.With mg compositions/cm
2The typical amounts that skin meter, the present composition are used at every turn is about 0.1mg/cm
2To about 20mg/cm
2The coating amount that is particularly useful is about 0.5mg/cm
2To about 10mg/cm
2
Can by for example use skin distillate medicinal water, salubrious distillate medicinal water, milk distillate medicinal water, cream, gel, foam, ointment, paste, emulsion, spray, aerosol, conditioner, nourishing agent, cosmetics, lip pomade, foundation cream, refer to/nail polish, the compositions of aftershave lotion, ball rod or deodorant stick, powder, wet goods form, implement the processing of keratinous tissue conditions, described compositions is intended to stay in some is aesthetic to reach on skin or other collenchyme, the beneficial effect (i.e. " leave " compositions) of in the prevention, in the treatment or others.After using compositions on the collenchyme (as skin), it is stayed on the skin preferably at least about 15 minutes, more preferably at least about 30 minutes, even more preferably at least about 1 hour, even more preferably at least several hours, as about 12 hours at most.Can process facial, hair and/or refer to/any surperficial position of toenail (for example, face, lip, zone, eyelid, scalp, neck, trunk, arm, hands, lower limb, foot, fingernail, toenail, hair of scalp, eyelashes, eyebrow etc.) now.Described compositions can distribute from bottle, wide mouthed bottle, pipe, folliculus, pouch, container, tottle, bottle, ampoule, capsule etc., maybe can integrate to be contained in the delivery form, as cleaning piece.Can carry out using of the present composition by using palm and/or finger.Also can be by means of device or instrument, as cotton balls, swab, liner, brush, eye dropper, powder puff, sponge, club, cleaning piece, foamed materials, nonwoven substrate, facial film, ball-type applicator, bar-shaped applicator, coating pen, spray applicator, aerosol apparatus, razor etc., use.Active substance can be contained in two kinds of broken pouches between the substrate.
In another embodiment, topical compositions use can skin treatment such as cleaning, decortication or tanned after carry out.
Guaranteeing to make collenchyme and another method of the compositions Continuous Contact of minimum content at least is to be applicable to that by use for example the patch of face is used described chemical compound.Said method especially can be used for problematic skin area, and described skin area needs more intensive treatment (as facial crows-feet zone, place between the eyebrows stricture of vagina, zone, upper lip etc. now).Described patch can be occlusion, half occlusion or not occlusion, and can be viscosity or inviscid.Said composition can be comprised in the patch, or is coated on the skin before using patch.Described patch also can comprise additional active substance, as is used for the chemical initiator of exothermic reaction, as PCT application WO 9701313 and the United States Patent (USP) 5,821,250,5,981,547 and 5,972 of authorizing people such as Wu, those described in 957.Described patch also can comprise electric energy (as battery), for example to increase send (as the ionotherapy) of described compositions and activating agent.Patch applies retention time on collenchyme preferably at least about 5 minutes, more preferably at least about 15 minutes, and also more preferably at least about 30 minutes, even more preferably at least about 1 hour, even a kind of form of more preferably handling as night evening.
The another kind of method of enhanced activity material beneficial effect be to use have two or three or four kind or more kinds of product and/or treatment step (as decortication, use one or more active substance Local treatment of the present invention afterwards, alopecia, use one or more active substance Local treatment of the present invention afterwards, or the like) cover box or embodiment.Can be in short time period (for example in one hour), or in the long period section in a day (for example morning and night), or even longer time period in (for example weekly or carried out in every month step in the embodiment, and carry out other step in the embodiment with more regularly benchmark (for example every day)), use the various components in the embodiment.
Orally administered composition and topical compositions can be used as the cover box and are packaged in together.In another embodiment, described Orally administered composition and described topical compositions are not packaged in together as the cover box, but the potential user of described scheme is apprised of (for example by advertisement, Product labelling), and Orally administered composition and topical compositions can combine with one another to make and be used for regulating keratinous tissue conditions.
The present invention also imagines via device to the collenchyme delivery of energy, energy send can with topical compositions use simultaneously and/or in succession (for example, in 10 minutes) carry out.The energy delivery apparatus can be sent the energy of various ways, includes but not limited to the energy of following form: light, heat, sound (comprising ultrasound wave), magnetic energy, electromagnetic energy (comprising rf wave and microwave), mechanical energy (decortication or crystallite mill instrument) and their combination.Sending of energy can be successive, pulse, synthetic, non-modulation and their combination.In one embodiment, described energy delivery apparatus is a hand-held.Alternatively, described energy delivery apparatus is wireless.
By device being maintained in the single area of collenchyme, subsequently described device is moved to another zone (or " punching press ") of tissue, apply energy.Alternatively, can when described device moves continuously or scan by tissue surface, apply energy.When using laser aid, described device will keep basic Continuous Contact with the collenchyme surface, and perhaps when using flash lamp, described device and collenchyme keep short distance, and energy points to the surface simultaneously.
In collenchyme, or alternatively in the chemical compound on being administered to tissue surface, can produce variations in temperature simultaneously.This variations in temperature is the variation except that any variations in temperature that is produced by delivery of energy self.For example, can before energy is sent, collenchyme be heated slightly, or alternatively, after energy is sent, collenchyme be cooled off.
For for the energy of ultraviolet source, wavelength is usually located in the UV-A scope of about 315 to about 400nm (nanometer).For for the energy of visible light source, wavelength usually at about 400nm to the scope of about 700nm.For for the energy of infrared (IR) light source, wavelength is extremely about to the scope of about 3000nm at about 700nm usually.The energy values of being sent or " output flow " can be at about 1J/cm
2To about 100J/cm
2Scope in, wherein " J " is meant joule.For light-pulse generator, pulse width about 0.001 second to about 3 seconds scope, the average pulse persistent period is about 0.001 second to about 1 second.Collenchyme surface area to be covered will change according to using.Send these and other relevant parameter with energy and depend on the type of processing and the type of pending tissue, and can come suitable selection by those skilled in the art.
The present invention also provides the article of commerce that comprises personal care composition described herein, wherein at least a described personal care composition, the packing that is used for described personal care composition and the show and colour relevant with described personal care composition comprise labelling and/or image, and described labelling and/or image are passed on following information to consumer: described personal care composition can be united the situation that is used for regulating mammiferous collenchyme that makes with the energy delivery apparatus.
Embodiment
It below is the non-limiting example of the present composition.Providing of embodiment only is the purpose that illustrates for example, should not be construed as limitation of the present invention, because under the situation that does not deviate from the spirit and scope of the present invention, its many changes are possible, and this will be recognized by those of ordinary skill in the art.In an embodiment, except as otherwise noted, all concentration are all listed with percentage by weight, side by side except minor materials, as diluent, filler etc.Therefore, listed preparation comprises listed component and any trace substance relevant with this component.It is evident that concerning the those skilled in the art of this area the selected of these accessory constituents will be according to the physics of selected concrete composition with chemical characteristic and different, to make invention as herein described.
| Content in the preparation (the component gram number in every 100g preparation) | ||||||
| Component | A | B | C | D | E | F |
| Disodiumedetate | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 |
| Oxynex | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 |
| The own oxygen phenylate of dihydroxy ethyl sulfonic acid | 0.100 | 0 | 0 | 0 | 0 | 0 |
| Tetrahydrocurcumin | 0 | 0.500 | 0 | 0 | 0 | 0 |
| Enoxolone | 0 | 0 | 0.300 | 0 | 0 | 0 |
| Thiotaine 1 | 0 | 0 | 0 | 5.000 | 0 | 0 |
| N-endecatylene acyl-L-phenylalanine | 0 | 0 | 0 | 0 | 1. 000 | 0 |
| The N-n acetylglucosamine n | 0 | 0 | 0 | 0 | 0 | 2.000 |
| Nicotiamide | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 |
| Citric acid | 0.015 | 0 | 0 | 0 | 0 | 0 |
| 2-Methylpentadecane | 3.000 | 3.000 | 3.000 | 3.000 | 3.000 | 3.000 |
| The isostearic acid isopropyl ester | 1.330 | 1.330 | 1.330 | 1.330 | 1.330 | 1.330 |
| N-Hamposyl L isopropyl ester | 0 | 0 | 5.000 | 0 | 0 | 0 |
| Poly-cottonseed acid sucrose ester | 0.670 | 0.670 | 0.670 | 0.670 | 0.670 | 0.670 |
| Poly methyl silsesquioxane | 0.250 | 0.250 | 0.250 | 0.250 | 0.250 | 0.250 |
| Cetearyl glucoside+16/octadecanol | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 |
| Docosanol | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 |
| Ethylparaben | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 |
| Propyl p-hydroxybenzoate | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 |
| Spermol | 0.320 | 0.320 | 0.320 | 0.320 | 0.320 | 0.320 |
| Stearyl alcohol | 0.480 | 0.480 | 0.480 | 0.480 | 0.480 | 0.480 |
| Tocopherol acetas | 0.500 | 0.500 | 0.500 | 0.500 | 0.500 | 0.500 |
| The PEG-100 stearate | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 |
| Glycerol | 7.000 | 7.000 | 7.000 | 7.000 | 7.000 | 7.000 |
| Titanium dioxide | 0.604 | 0.604 | 0.604 | 0.604 | 0.604 | 0.604 |
| Polyacrylamide+C13-14 isoparaffin+laureth-7 | 3.000 | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 |
| Pantothenylol | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
| Benzylalcohol | 0.400 | 0.4 00 | 0.400 | 0.400 | 0.400 | 0.400 |
| Polydimethylsiloxane+dimethiconol | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 |
| Water (to 100g) | To 100 | To 100 | To 100 | To 100 | To 100 | To 100 |
| Amount to | 100 | 100 | 100 | 100 | 100 | 100 |
1 Thiotaine is the solution of ergothioneine, and ergothioneine content is 0.04% to 0.05%.
Content in the preparation (the component g number in every 100g preparation)
| Component | G | H | I |
| Disodiumedetate | 0.100 | 0.100 | 0.100 |
| Oxynex | 2.000 | 2.000 | 2.000 |
| Cetylpyridinium chloride | 0.200 | 0 | 0 |
| Pitera | 0 | 10 | 0 |
| The ascorbyl glucoside | 0 | 0 | 2.000 |
| Nicotiamide | 5.000 | 5.000 | 5.000 |
| Polyquaternary ammonium salt 37 | 0 | 0 | 0 |
| 2-Methylpentadecane | 3.000 | 3.000 | 3.000 |
| The isostearic acid isopropyl ester | 1.330 | 1.330 | 1.330 |
| Poly-cottonseed acid sucrose ester | 0.670 | 0.670 | 0.670 |
| Poly methyl silsesquioxane | 0.250 | 0.250 | 0.250 |
| Cetearyl glucoside+16/octadecanol | 0.200 | 0.200 | 0.200 |
| Docosanol | 0.400 | 0.400 | 0.400 |
| Ethylparaben | 0.200 | 0.200 | 0.200 |
| Propyl p-hydroxybenzoate | 0.100 | 0.100 | 0.100 |
| Spermol | 0.320 | 0.320 | 0.320 |
| Stearyl alcohol | 0.480 | 0.480 | 0.480 |
| Tocopherol acetas | 0.500 | 0.500 | 0.500 |
| The PEG-100 stearate | 0.100 | 0.100 | 0.100 |
| Glycerol | 7.000 | 7.000 | 7.000 |
| Titanium dioxide | 0.604 | 0.604 | 0.604 |
| Polyacrylamide+C13-14 isoparaffin+laureth-7 | 2.000 | 2.000 | 2.000 |
| Pantothenylol | 1.000 | 1.000 | 1.000 |
| Benzylalcohol | 0.400 | 0.400 | 0.400 |
| Polydimethylsiloxane+dimethiconol | 2.000 | 2.000 | 2.000 |
| Water (to 100g) | To 100 | To 100 | To 100 |
| Amount to | 100 | 100 | 100 |
Although, it will be apparent to those skilled in the art that many other variations and modifications may be made in the case of without departing from the spirit and scope of protection of the present invention with specific embodiments explanation with described the present invention.Therefore, in additional claims, comprise all such changes and modifications that belong in the scope of the invention consciously.
The relevant portion of all documents of quoting in background of invention, preferred embodiment general introduction and illustrative and the embodiment preferred detailed description is incorporated herein by reference; The quoting and may not be interpreted as of any document to its approval as prior art of the present invention.
Claims (12)
1. personal care composition, described compositions comprises:
A) Aden's perfume base malonic acid ethylhexyl;
B) at least a additional skin and/or hair-care active substance, described active substance is selected from the group of being made up of following material: tetrahydrocurcumin, osamine, peptide, plant sterol, two alkanoyl hydroxyprolines, the primoline chemical compound, cetylpyridinium chloride, N-acyl amino acid compound, hesperetin, the Semen Brassicae Junceae extract, glycyrrhizic acid, enoxolone, ergothioneine, melanonostatin, sterol ester, idebenone, dehydroactic acid, licochalcone A, creatine, kreatinin, the Radix Agrimoniae extract, yeast extract, beta glucan, alpha-glucans, their salt, their derivant, their precursor, and/or their combination; With
C) dermatological acceptable carrier.
2. personal care composition as claimed in claim 1, wherein said at least a additional skin and/or hair-care active substance are osamine, described osamine comprises the N-acetyl glucosamine.
3. personal care composition as claimed in claim 1, wherein said at least a additional skin and/or hair-care active substance are N-acyl amino acid compound, described chemical compound comprises N-endecatylene acyl-L-phenylalanine.
4. as each described personal care composition in the claim 1 to 3, described compositions also comprises 0.001% to 10% annexing ingredient by weight, and described annexing ingredient is selected from the group of being made up of following material: the desquamation active substance, the anti-acne active substance, wrinkle repairing activity material, antioxidant, free radical scavenger, chelating agen, flavonoid, antiinflammatory, the scorching agent of anti-cellulite, skin lightening agent, anti-microbial active matter, antifungus active substance, conditioner, thickening agent, water soluble vitamins, fat soluble vitamin, particulate matter, local anesthetic, and their combination.
5. method of regulating mammiferous keratinous tissue conditions said method comprising the steps of:
(a) comprise the personal care composition of Aden's perfume base malonic acid ethylhexyl to required tissue regions local application; With
(b) use second personal care composition that comprises sunscreen actives to required tissue regions subsequently.
6. method as claimed in claim 5, described method is further comprising the steps of:
(c) apply energy via the energy delivery apparatus to described tissue regions.
7. method as claimed in claim 6, wherein the enforcement of the enforcement of step (c) and step (a) is carried out simultaneously at least in part and/or is carried out in succession.
8. as each described method in the claim 5 to 7, wherein apply described energy with certain form, described form is selected from the group of being made up of following energy: luminous energy, heat energy, acoustic energy, magnetic energy, electromagnetic energy, mechanical energy and their combination.
9. method of regulating mammiferous keratinous tissue conditions said method comprising the steps of:
(a) comprise the personal care composition of Aden's perfume base malonic acid ethylhexyl to required tissue regions local application; With
(b) apply energy via the energy delivery apparatus to described tissue regions.
10. method as claimed in claim 9, wherein step (a) and step (b) implements at least some crossovers.
11. method as claimed in claim 9, wherein implementation step (b) in 10 minutes of implementation step (a).
12. as each described method in the claim 9 to 11, wherein apply described energy with certain form, described form is selected from the group of being made up of following energy: luminous energy, heat energy, acoustic energy, magnetic energy, electromagnetic energy, mechanical energy and their combination.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68162605P | 2005-05-17 | 2005-05-17 | |
| US60/681,626 | 2005-05-17 | ||
| US11/406,477 | 2006-04-18 |
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| Publication Number | Publication Date |
|---|---|
| CN101175468A true CN101175468A (en) | 2008-05-07 |
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| CNA2006800169244A Pending CN101175468A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800168684A Pending CN101175472A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169189A Pending CN101175467A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA200680016867XA Pending CN101175471A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169259A Pending CN101175469A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
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| CNA2006800168684A Pending CN101175472A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169189A Pending CN101175467A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA200680016867XA Pending CN101175471A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169259A Pending CN101175469A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
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| CN102215856B (en) * | 2008-12-01 | 2014-03-05 | 莱拉制药用品私营有限责任公司 | Topical formulation(s) for treatment of inflammation, skin and mucosal disorders and other diseases thereof |
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| CN102573777A (en) * | 2009-10-29 | 2012-07-11 | 宝洁公司 | Transparent cosmetic composition |
| CN101862280A (en) * | 2010-01-29 | 2010-10-20 | 重庆灵方生物技术有限公司 | Sunscreen containing Zingiber corallinum Hance essential oil |
| CN103002870A (en) * | 2010-07-22 | 2013-03-27 | 宝洁公司 | Methods for improving the appearance of hyperpigmented spot(s) using an extract of laminaria saccharina |
| EP2448548B1 (en) * | 2010-07-22 | 2017-03-01 | The Procter and Gamble Company | Method for improving the appearance of hyperpigmented spot(s) using an extract of laminaria saccharina |
| AU2010365039B2 (en) * | 2010-12-07 | 2015-06-18 | Colgate-Palmolive Company | Oral care compositions comprising a quinone and a further antimicrobial agent |
| CN104470496A (en) * | 2012-05-30 | 2015-03-25 | 宝洁公司 | Cosmetic products for reducing hair appearance |
| WO2014043230A2 (en) * | 2012-09-14 | 2014-03-20 | Elizabeth Arden, Inc. | Formulations comprising idebenone, n-acetyl-s-farnesyl-l-cysteine and ergothioneine and uses thereof |
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| CN104936577B (en) * | 2013-01-21 | 2017-09-08 | 富士胶片株式会社 | Emulsion oil-in-water composition and application thereof |
| TWI549696B (en) * | 2014-09-05 | 2016-09-21 | 中國醫藥大學 | Use of ergothioneine for activating nrf2 signaling pathway of cell |
| JP6842419B2 (en) * | 2015-09-02 | 2021-03-17 | 株式会社林原 | Topical skin for reducing yellowing |
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| CN116350529A (en) * | 2022-12-12 | 2023-06-30 | 南京纽邦生物科技有限公司 | Methods and compositions for improving or maintaining skin health in mammals |
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2006
- 2006-05-17 CN CNA2006800169244A patent/CN101175468A/en active Pending
- 2006-05-17 CN CNA2006800168684A patent/CN101175472A/en active Pending
- 2006-05-17 CN CNA2006800169189A patent/CN101175467A/en active Pending
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102215856B (en) * | 2008-12-01 | 2014-03-05 | 莱拉制药用品私营有限责任公司 | Topical formulation(s) for treatment of inflammation, skin and mucosal disorders and other diseases thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101175469A (en) | 2008-05-07 |
| CN101175467A (en) | 2008-05-07 |
| CN101175472A (en) | 2008-05-07 |
| CN101175471A (en) | 2008-05-07 |
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