CN101175471A - Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate - Google Patents
Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate Download PDFInfo
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- CN101175471A CN101175471A CNA200680016867XA CN200680016867A CN101175471A CN 101175471 A CN101175471 A CN 101175471A CN A200680016867X A CNA200680016867X A CN A200680016867XA CN 200680016867 A CN200680016867 A CN 200680016867A CN 101175471 A CN101175471 A CN 101175471A
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Abstract
The present invention provides personal care compositions containing ergot sulfur gene. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.
Description
Technical field
The present invention relates to comprise the personal care composition of ergothioneine.Above-mentioned composition can be used for regulating the mammiferous keratinous tissue conditions of the above-mentioned processing of needs, especially can be used for blast skin.
Background of invention
Consumer at present obtainable many personal care products is intended to improve collenchyme such as skin, hair and refer to/health and the physical appearance of toenail.In these products, the overwhelming majority relates to delay, minimize or even eliminate a crease in the skin and the histology changes, described variations is typical relevant to the infringement of human skin with skin aging or environment.Yet, still need cosmetic agent by being used as blast skin or reducing Pigmented cosmetic agent and prevent, postpone and/or handle the uneven colour of skin.
Mammiferous collenchyme, especially Ren Lei skin and hair are subjected to the infringement of many external and intrinsic factor.Above-mentioned extrinsic factor comprises ultraviolet radiation, environmental pollution, wind, Exposure to Sunlight, infrared radiation, low humidity, deleterious surfactant, grinding agent etc.On the other hand, intrinsic factor comprise that other biochemistry in chronological age and the skin changes.No matter be extrinsic factor or intrinsic factor, they all cause producing tangible skin injury sign.Typical skin injury comprises the thinning of skin of the Lock-in along with the increase at age.Along with above-mentioned thinning of skin, cell and the blood vessel of supplying with skin are reducing.In addition, corium-epidermis junction is smooth day by day, and this causes the mechanical of this junction to die down." The Aging of Skin:ChronoagingVersus Photoaging " (the 3rd to page 4, nineteen ninety for Photodermatol.Photoimmunol.Photomed., the 7th volume) referring to for example Oikarinen.Visible other damage or variation comprise microgroove, corrugate on the aging or damaged skin, hyperpigmentation, sallow, sagging, black eye, swollen eye, pore increase, renewal rate slows down and abnormal desquamation or decortication.Other damage that causes owing to extrinsic factor and intrinsic factor comprises tangible dead bark (be exfoliation, peel off, coarse).For hair, except other problem, these extrinsic factor and intrinsic factor also can cause bleaching hair, hair bifurcated, slim and frahile, coarse, trichomadesis, hair growth speed to slow down etc.Therefore, need to try hard to improve the product and the method for these keratinous tissue conditions.
Summary of the invention
The applicant finds that the personal care composition that comprises some active substance can be used for providing preventative and therapeutic treatment to keratinous tissue conditions, especially blast skin treatment.
According to an embodiment preferred, a kind of personal care composition now is provided, described compositions comprises ergothioneine; At least a additional skin and/or hair-care active substance; And dermatological acceptable carrier.Described active substance is selected from the group of being made up of following material: osamine, primoline chemical compound, N-acyl amino acid compound, cetylpyridinium chloride and their combination.
According to another embodiment preferred, a kind of personal care composition now is provided, described compositions comprises ergothioneine; N-acyl amino acid compound; Nicotiamide; Pantothenylol; Vitamin e acetate; With the dermatological acceptable carrier.
The invention still further relates to article of commerce, described article of commerce comprises personal care composition as disclosed herein.According to an embodiment preferred, now also provide a kind of article of commerce, described article of commerce comprises personal care composition of the present invention; At least a packing that is used for described personal care composition; And the show and colour relevant with described personal care composition.Described show and colour comprises labelling and/or image, and described labelling and/or image are passed on following information: the described personal care composition of local application can improve people's skin color or skin color.
According to another embodiment preferred, now also provide a kind of article of commerce, described article of commerce comprises the personal care composition that comprises ergothioneine; At least a packing that is used for described personal care composition; And the show and colour relevant with described personal care composition.Described show and colour comprises labelling and/or image, and described labelling and/or image are passed on following information: described personal care composition can be united use with the energy delivery apparatus, to be used to regulate the situation of mammiferous collenchyme.
The invention still further relates to the method that is used to regulate mammiferous keratinous tissue conditions.According to some embodiment preferred, described method comprises the step to the personal care composition as described in the present invention of the safe and effective amount of mammiferous collenchyme local application of the above-mentioned processing of needs.
According to an alternative embodiment, described method comprises to organizing the desired zone local application to comprise the personal care composition of ergothioneine; And subsequently to the step of organizing desired zone to use to comprise second personal care composition of sunscreen actives.Is nonessential via the energy delivery apparatus to the additional step that tissue regions applies energy.
Detailed Description Of The Invention
Except as otherwise noted, all percentage ratios used herein and ratio are all by the weight of total composition, and all measurements are all carried out at 25 ℃.
Compositions of the present invention can comprise, basically by or be grouped into by solvent described herein and nonessential one-tenth.Used herein " basically by ... form " be meant that described compositions or component can comprise supplementary element, as long as described supplementary element can not change the new characteristic of fundamental sum of claimed compositions of the present invention or method in itself.
Term used herein " collenchyme " is meant the horny layer that contains as mammal outermost layer guard cover, and it includes but not limited to skin, hair, toenail, fingernail, epidermis, hoof etc.
Term used herein " local application " is meant to be used compositions of the present invention or be applied on the collenchyme surface.
Term used herein " dermatological is acceptable " is meant that described compositions or component are suitable for contacting with human collenchyme, and does not have unsuitable toxicity, incompatibility, unstability, atopic reaction etc.
Term used herein " safe and effective amount " is meant that the amount of chemical compound or compositions is enough to significantly produce positive beneficial effect, preferred positive collenchyme outward appearance or the sensation beneficial effect of producing, this beneficial effect comprises beneficial effect independently disclosed herein or combination, this amount is enough low again to avoid serious adverse (promptly simultaneously, in the rational determination range of technical staff, provide rational effect danger than).
Term used herein " hyperpigmentation after the inflammation " be meant because of the inflammation incident (as acne, scratch, insecticide sting or sting, Exposure to Sunlight etc.) variation of the melanin content that reflects, especially obvious to the experimenter of dark skin.
Term used herein " hyperpigmentation " is meant that wherein pigmentation is greater than the Pigmented skin area of skin adjacent domain (as eyespot, senile plaque etc.).
Term used herein " comes off, peels and/or upgrade " and is meant the outer layer of stratum corneum removal of (comprising horny layer).
Term used herein " oiliness and/or glossy appearance " is meant that the mammal skin with smooth appearance is tending towards demonstrating by the excretory oils and fats in body of gland source, sebum and/or perspiration separately.
Term used herein " sagging " is meant the situation such as lax, sagging of skin, and described situation is by the proteic loss of skin elasticity, destruction, change and/or unusual the generation.
Term used herein " smooth " and " softening " are meant that the surface that changes collenchyme is to improve sense of touch.
Term used herein " sallow " is meant the protein glycation effect that together takes place owing to for example typical case and skin aging and lipofuscin gathers or peripheral blood flow minimizing effect, because of the loss of skin component, destruction, change and/or unusual so that situations such as the skin color that their variable colors (for example color jaundice) produce is greyish white, jaundice.
Compositions of the present invention can be used for local application, and can be used for regulating keratinous tissue conditions.Because intrinsic factor and/or extrinsic factor can bring out or cause the various situations of health, so usually need be, especially the human skin situation is regulated to keratinous tissue conditions.For example, " adjusting skin " comprises preventative adjusting and/or therapeutic regulation, and can comprise following one or more beneficial effects: thicken and (promptly construct epidermal area and/or skin corium and/or hypodermic layer such as the fat and the muscle of skin, and under suitable situation, structure refers to/horny layer of toenail and hair shaft) to reduce atrophy (as the atrophy of skin), increase curling of corium-epidermis border, reduce plain dyschromasia of non-black such as eye pouch, the rash speckle (for example, by the inhomogeneous redness that causes as acne erythematosa) (hereinafter being referred to as erythema) and sallow (canescence or yellow), the variable color that minimizing is caused by telangiectasis or spider shape blood vessel, minimizing by melanin (as eyespot, senile plaque, inhomogeneous pigment calmness) (the lipofuscin for example of other chromophore and in the skin, protein cross those as occurring with saccharification, or the like) variable color that causes.Preventative adjusting used herein comprises delay, minimizes and/or prevents visible and/or palp skin discontinuity (for example, appreciable in irregular texture, microgroove, wrinkle, sagging, stretching vestige, honeycomb inflammation, swollen eye or the like skin or feel).Therapeutic regulation used herein comprises the discontinuity of improving (for example reduce, farthest reduce and/or eliminate) skin.Regulating skin comprises and improves skin appearance and/or sensation.
Term used herein " adjusting skin " is intended to comprise the adjusting of above-mentioned sign, and irrelevant with the mechanism of the origin cause of formation.
Term used herein " labelling " is meant identification sign, comprises literal and/or figure.
Term used herein " image " is meant photo, diagram and/or other paint of mammal or object.
Term used herein " packing " is meant when product is published, to small part be placed on the personal care composition or personal care composition around structure or material." main packing " is meant any container, comprises its shell, pump, lid or other external object, and wherein said compositions is in direct contact condition.And " less important packing " is meant the relevant additional materials of any and main packing, and container for example is as surrounding, comprise or contact box or the polymerization sleeve pipe of mainly packing to small part.
Term used herein " show and colour " is meant tangible expression media, himself or peripheral device auxiliary down, the existence of decorrelation personal care composition that can make people, or show the quality or the advantage of described compositions.
The compositions of the present invention that comprises solvent and optional component thereof will be explained below.
Component
Ergothioneine
Compositions of the present invention comprises the ergothioneine of safe and effective amount.The content of ergothioneine is preferably about 0.0001% to about 20% by the weight of described compositions, and more preferably from about 0.001% to about 5%, even more preferably from about 0.01% to about 1%.Preferred ergothioneine is Thiotaine
, it is the commercial solution of chemicals ergothioneine, available from Barnet Products.
Additional skin and/or hair-care active substance
Compositions typical case of the present invention comprises at least a additional skin and/or the hair-care active substance of safe and effective amount.The unrestricted exemplary lists of above-mentioned active substance comprises osamine; vitamin B3; retinoid; hydroquinone; peptide; plant sterol; two alkanoyl hydroxyprolines; primoline; salicylic acid; N-acyl amino acid compound; sunscreen actives; water soluble vitamins; fat soluble vitamin; hesperetin; the Semen Brassicae Junceae extract; glycyrrhizic acid; enoxolone; carnosine; Yoshinox BHT (BHT) and butylated hydroxyanisol (BHA); Antisolaire; cetylpyridinium chloride; tetrahydrocurcumin; the vanillin or derivatives thereof; Aden's perfume base malonic acid ethylhexyl; melanonostatin; sterol ester; idebenone; dehydroactic acid; yeast extract is (as Pitera
), beta glucan, alpha-glucans, fatty acid (especially polyunsaturated fatty acid), 1-oxygen-2-mercaptopyridine zinc (ZPT), antifungal, mercaptan compound (as N-acetylcysteine, glutathion, thioglycol acid esters), other vitamin (vitamin B12), beta-carotene, ubiquinone, aminoacid, their salt, their derivant, their precursor and/or their combination.A part of further describing in these additional activity materials hereinafter is provided.
Skin of the present invention and/or hair-care active substance can be used for blast skin.Blast skin can take place by number of mechanisms, comprises antioxidant mechanism, trypsin inhibitory action, antiinflammatory mechanism, nitric oxide scavenging action, tyrosinase inhibitory action etc.Therefore, exist these machine-processed chemical compounds to have the probability of blast skin.
1. osamine (amino sugar)
Compositions of the present invention can comprise the osamine of safe and effective amount, and it also is called as amino sugar.The osamine chemical compound that can be used among the present invention is described in PCT announcement WO 02/076423 and the United States Patent (USP) 6,159,485.
When existing, described compositions comprises by the weight of described compositions preferred about 0.01% to about 15%, and more preferably from about 0.1% to about 10%, even 0.5% to about 5% osamine more preferably from about.
Osamine derives from synthetic or natural, and the mixture (for example being derived from the natural extract or the mixture of synthetic) that can be used as pure compound or chemical compound uses.Glycosamine is present in many Crustaceans and also usually can derive from fungal source.Term used herein " osamine " comprises the isomer and the tautomer of above-mentioned substance and salt (as HCl salt) thereof, and can be commercially available from Sigma ChemicalCo..
The embodiment that can be used for osamine of the present invention comprises glycosamine, N-acetyl glucosamine, glucosamine sulfate, mannosamine, N-acetylmannosamine, galactosamine, N-acetyl group galactosamine, their isomer (as stereoisomer) and their salt (as HCl salt).What preferably can be used for this paper is glycosamine, especially D-glycosamine and N-acetyl glucosamine, especially N-acetyl group-D-glycosamine.
2. vitamin B
3
Compositions of the present invention can comprise the vitamin B of safe and effective amount
3Chemical compound.Vitamin B
3Chemical compound especially can be used for regulating skin, as United States Patent (USP) 5,939, described in 082.When existing, described compositions comprises by the weight of described compositions preferred about 0.01% to about 50%, and more preferably from about 0.1% to about 20%, even more preferably from about 0.5% to about 10%, also more preferably from about 1% to about 7%, even 2% to about 5% vitamin B more preferably from about
3Chemical compound.
" vitamin B used herein
3Chemical compound " be meant chemical compound with following formula structure:
Wherein R is-CONH
2(being nicotinamide) ,-COOH (being nicotinic acid) or-CH
2OH (being nicotinyl alcohol); Its derivant; Salt with any aforesaid compound.
Aforementioned vitamin B
3The exemplary derivant of chemical compound comprises nicotinate, and described ester comprises the non-vasodilation ester (as tocopheryl nicotinate, myristyl nicotinate) of nicotinic acid.
Suitable vitamin B
3Examples for compounds be well known in the art and can be from a plurality of sources (as Sigma Chemical Company, ICN Biomedicals, Inc. and AldrichChemical Company) commercially available.Preferably can be used for the vitamin B among the present invention
3Chemical compound is a nicotiamide.
3. primoline
Can be used for primoline chemical compound among the present invention corresponding to having those of following chemical constitution:
R wherein
1And R
2Comprise organic acid (as sulfonic acid etc.).
When existing, the content of described primoline is preferably about 0.0001 to about 25% by the weight of described compositions, and more preferably from about 0.001 to about 10%, and more preferably from about 0.01 to about 5%, even more preferably from about 0.02 to about 2.5%.
Topical compositions of the present invention can nonessentially comprise one or more primoline chemical compounds of safe and effective amount, its salt and its derivant.Primoline derivant used herein comprises all isomers and the tautomer of primoline chemical compound, includes but not limited to organic acid and mineral acid, for example sulfonic acid, carboxylic acid etc.Preferably, the primoline chemical compound comprises dihydroxy ethyl sulfonic acid primoline, and it is with trade name Elestab
HP100 is commercially available from LaboratoiresSerobiologiques.
4.N-amic acid chemical compound
Topical compositions of the present invention can comprise one or more N-amic acid chemical compounds of safe and effective amount.Described aminoacid can be any aminoacid known in the art.N-acyl amino acid compound of the present invention meets the following formula structure:
Wherein R can be hydrogen, alkyl (replacement or unsubstituted, side chain or straight chain), or the combination of alkyl and aryl.Aminoacid known in the art may side chain tabulation be described among " Biochemistry " of the Stryer that announced by W.H.Freeman and Company in 1981.R
1Can be saturated or undersaturated, straight or branched, replacement or unsubstituted C
1To C
30Alkyl; Replace or unsubstituted aryl; Or their mixture.
N-amic acid chemical compound is preferably selected from N-acyl group phenylalanine, N-acyl group tyrosine, their isomer, their salt, and their derivant.Aminoacid can be D or L isomer, or their mixture.N-acyl group phenylalanine meets the following formula structure:
R wherein
1Can be C
1To C
30Saturated or undersaturated, straight or branched, replacement or unsubstituted alkyl; Replace or unsubstituted aromatic group or their mixture.
N-acyl group tyrosine meets the following formula structure:
R wherein
1Can be C
1To C
30Saturated or undersaturated, straight or branched, replacement or unsubstituted alkyl; Replace or unsubstituted aromatic group or their mixture.
What especially can be used as the cosmetic agent that makes local colour of skin unanimity (blast skin or reduce pigmentation) is N-endecatylene acyl-L-phenylalanine.This reagent belongs to generalized N-acyl group Phenylalamine derivatives classification, and its acyl group is a C11 monounsaturated fatty acid part, and aminoacid is the L-isomer of phenylalanine.N-endecatylene acyl-L-phenylalanine meets the following formula structure:
N-endecatylene acyl group used herein-L-phenylalanine can trade name Sepiwhite
Commercially available from SEPPIC.
When existing, the content of N-acylamino acid is preferably about 0.0001% to about 25% by the weight of described compositions, and more preferably from about 0.001% to about 10%, and more preferably from about 0.01% to about 5%, even more preferably from about 0.02% to about 2.5%.
5. sunscreen actives
This theme inventive compositions can comprise sunscreen actives." sunscreen actives " used herein comprises sunscreen and physical sunscreen frost.Suitable sunscreen actives can be organic or inorganic.
There is multiple conventional sunscreen actives to be applicable to this paper.People such as Sagarin disclose multiple suitable actives matter since 189 pages at the VIII chapter of " CosmeticsScience and Technology " (1972) to later part.Especially Shi Yi sunscreen is p-methoxycinnamic acid-2-Octyl Nitrite (commercially available with trade name PARSOL MCX), 4,4 '-tert-butyl group methoxy dibenzoyl methane (commercially available) with trade name PARSOL 1789,2-hydroxyl-4-methoxyl group benzophenone, the octyldimethyl para-amino benzoic acid, two times of acyl trioleates, 2,2-dihydroxy-4-methoxyl group benzophenone, 4-(two (hydroxypropyl)) benzocaine, 2-cyano group-3,3-diphenylacrylate-2-Octyl Nitrite, salicylic acid-2-Octyl Nitrite, para-amino benzoic acid glyceride, 3,3,5-trimethylcyclohexyl salicylate, artificial neroli oil, ESCAROL 507 or Aminobenzoate, ESCAROL 507-2-Octyl Nitrite, 2-Phenylbenzimidazole-5-sulfonic acid, 2-(to dimethylaminophenyl)-5-sulfonic acid benzoxazole acid, octocrylene, zinc oxide, titanium dioxide, and the mixture of these chemical compounds.
The organic sunscreen active substance that preferably can be used in the compositions of the present invention is p-methoxycinnamic acid-2-Octyl Nitrite, PAROSOL 1789,2-hydroxyl-4-methoxy benzophenone, 2-Phenylbenzimidazole-5-sulfonic acid, octyldimethyl para-amino benzoic acid, octocrylene, zinc oxide, titanium dioxide, and their mixture.Especially preferred sunscreen actives comprises 4,4 '-tert-butyl group methoxy dibenzoyl methane, p-methoxycinnamic acid-2-Octyl Nitrite, Phenylbenzimidazolesulfonic acid, octocrylene, zinc oxide and titanium dioxide and their mixture.
When existing, the content of described sunscreen actives is preferably about 1% to about 20% by the weight of described compositions, and more preferably from about 2% to about 10%.Its accurate consumption will depend on selected sunscreen and required sun protection factor (SPF).
6. cetylpyridinium chloride
Compositions of the present invention can comprise the cetylpyridinium chloride of safe and effective amount.The replacement form of hexadecylpyridinium chloride comprises that one or two the substituent carbon chain lengths (being typically alkyl) on the quaternary nitrogen wherein is about 8 to about 20, the typical case is about 10 to about 18 carbon atoms, remains substituent group (being typically alkyl or benzyl) simultaneously and has low carbon atom number more according to appointment 1 to those of about 7 carbon atoms (being typically methyl or ethyl).The example of typical case's quaternary ammonium reagent is Dodecyl trimethyl ammonium chloride, TPC, brominated phenododecinium bromide, chlorination N-myristyl-4-ethylpyridine, dodecyl dimethyl (2-benzene oxygen ethyl) ammonium bromide, benzyl dimethyl stearyl chlorination ammonium, quaternized 5-amino-1, two (2-the ethylhexyl)-5-methyl hexahydropyrimidines of 3-, alkyl benzyl dimethyl ammonium chloride, benzethonium chloride and methylbenzethonium chloride.Other chemical compound is two-4-(R-amino)-1-pyridine alkane, and it is disclosed in United States Patent (USP) 4,206, in 215.
The content of cetylpyridinium chloride counts about 0.005% to about 10% by the weight of described compositions, and more preferably from about 0.01% to about 5%, and more preferably from about 0.05% to about 2%.Cetylpyridinium chloride is the inhibitor of tryrosinase.
7. water soluble vitamins
Compositions of the present invention can comprise one or more water soluble vitamins of safe and effective amount.The example of water soluble vitamins includes but not limited to water-soluble sexual type vitamin B (as vitamin B5 and vitamin B6 (as pyridoxin)), vitamin B derivant, vitamin C (as the ascorbyl glucoside), vitamin C derivatives (as magnesium ascorbyl phosphate, sodium ascorbyl phosphate and ascorbic palmitate), vitamin K, vitamin K derivant, their provitamin such as pantothenylol, and their mixture.When containing element-vitamine compound in the compositions of the present invention, said composition preferably comprises by the weight of described compositions about 0.0001% to about 50%, more preferably from about 0.001% to about 10%, also more preferably from about 0.01% to about 8%, and 0.1% to about 5% element-vitamine compound more preferably from about also.
8. fat soluble vitamin
Compositions of the present invention can comprise one or more fat soluble vitamins of safe and effective amount.The example of fat soluble vitamin includes but not limited to oil-soluble type vitamin D, vitamin D-derivatives, vitamin E (as vitamin e acetate), vitamin e derivative, their provitamin such as pantothenylol, and their mixture.When comprising the fat soluble vitamin chemical compound in the compositions of the present invention, described compositions preferably comprises by the weight of described compositions about 0.0001% to about 50%, more preferably from about 0.001% to about 10%, also more preferably from about 0.01% to about 8%, 0.1% to about 5% fat soluble vitamin chemical compound more preferably from about also.
Optional component
Compositions of the present invention can comprise other composition commonly used in the multiple given product type, and precondition is that they can change beneficial effect of the present invention acceptably.
In the time of in being incorporated into compositions, optional component should be applicable to human collenchyme and contact reasonably do not having unsuitable toxicity, incompatibility, unstability, atopic reaction or the like in the determination range." CTFA Cosmetic Ingredient Handbook " second edition (1992) has been described multiple non-limiting beauty treatment and the ingredient that is generally used for the skin nursing field, and they are applicable in the compositions of the present invention.Other embodiment of these constituent classes comprises: grinding agent, absorbent, aesthetic feeling component such as aromatic, pigment, stain/coloring agent, quintessence oil, the skin sensitizer, astringents etc. are (as Oleum Caryophylli, menthol, Camphora, Eucalyptus oil, acetaminol, menthyl lactate, the Radix Hamamelidis Mollis distillate), anti-acne agents, anti-caking agent, defoamer, antimicrobial (as butyl carbamic acid iodine propyl ester), antioxidant, binding agent, bio-additive, buffer agent, extender, chelating agen, chemical addition agent, coloring agent, the cosmetics astringent, cosmetics insecticide, denaturant, medicinal astringent, external-use analgesic, film former or film forming matter polymer (as eicosylene and vinylpyrrolidone copolymers) as helping compositions film forming characteristics and film forming substantivity, opacifier, the pH regulator agent, propellant, Reducing agent, sequestering agent, skin-whitening agents and skin lightening agent, skin conditioning agent, skin is consoled agent and/or consolidant and derivant, skin treatment agents, thickening agent, vitamin, and their derivant.
Other optional component that can be used in the compositions of the present invention comprises that the U.S. announces those that describe among the 2004/0175347A1, comprises the desquamation active substance, as salicylic acid and zwitterionic surfactant; The anti-acne active substance is as resorcinol, sulfur, erythromycin, zinc, dehydroactic acid; Anti-wrinkle active substance/anti-atrophy active substance; Antioxidant/free radical scavenger is as tocopherol; Chelating agen is as furil-dioxime and derivant thereof; Flavonoid; Antiinflammatory; The scorching agent of anti-cellulite; Tanned active substance is as dihydroxy acetone; Skin lightening agent; Antimicrobial and antifungus active substance; Sunscreen actives; Conditioner is as glycerol, carbamide, vaseline, Olestra and their combination; Thickening agent is as carboxylic acid polyalcohol, cross-linked polyacrylate polymer, polyacrylamide polymers, polysaccharide, natural gum; And particulate material.
The dermatological acceptable carrier
Topical compositions of the present invention also can comprise the dermatological acceptable carrier that is used for active substance.Phrase used herein " dermatological acceptable carrier " is meant that carrier is suitable for being locally applied to collenchyme, has good aesthetic properties, with active substance of the present invention and any other component compatibility, and does not cause any safety or toxicity problem.The carrier of safe and effective amount account for described compositions about 50% to about 99.99%, preferred about 60% to about 99.9%, more preferably from about 70% to about 98%, even more preferably from about 80% to about 95%.
Carrier can take various forms.For example, emulsion carriers can be used for the present invention.Described emulsion carriers includes but not limited to O/w emulsion, water-in-oil emulsion, water-covered siloxane emulsion, water-in-silicone emulsion, water-in-oil-in-water compositions and water-in-silicone bag fat liquor.
Preferred carrier comprises emulsion, as O/w emulsion and water-in-oil emulsion, and for example water-covered siloxane emulsion or water-in-silicone emulsion.Such just as understood as technical staff, given component will mainly be assigned in water or the oil phase, and this depends on the water solublity/allocability of this component in compositions.Especially preferred O/w emulsion.
Generally comprise aforesaid solution and lipoid or oil according to emulsion of the present invention.Lipoid and oil can derive from animal, plant or oil, and can natural or synthetic (promptly manually making).Preferred emulsions also comprises wetting agent, for example glycerol.By the weight of described compositions, emulsion preferably also comprises about 0.1% to about 10%, more preferably from about 0.2% to about 5% emulsifying agent.Emulsifying agent can be nonionic, anion or cationic.Examples of suitable emulsifiers is disclosed in " Detergents andEmulsifiers " North America version the 317th of for example United States Patent (USP) 3,755,560, United States Patent (USP) 4,421,769 and McCutcheon in the 324th page (1986).
According to required product type, suitable emulsion can have the very wide viscosity of scope.Preferred exemplary low viscosity emulsion has about 5E-5m
2/ s (50 centistoke) or lower, more preferably from about 1E-5m
2/ s (10 centistoke) or lower, even 5E-6m more preferably from about
2/ s (5 centistoke) or lower viscosity.
Compositions of the present invention also can comprise the acceptable topical vehicle of other dermatological, and can comprise oral carrier.For example, another kind of topical vehicle can be the cleaning agent (for example, soap slab, shampoo, foamed cleanser, liquid cleaner, bath shampoo, cleaning towel etc.) that comprises surfactant.In above-mentioned carrier, surfactant can be anion, cation, amphion, nonionic, or these mixture.Another kind of topical vehicle is coloured cosmetics (lip pomade, kermes, informer, mascara, foundation creams, refer to/the toenail wet goods).A kind of oral carrier is beverage, food, pill, capsule, powder, capsule sheet etc.
Composition forms
The topical compositions of this theme invention includes but not limited to lotion, emulsion, mousse, serosity, spray, aerosol, foam, club, lip pencil thing, gel, cream and ointment, and described compositions can comprise the acceptable emollient of dermatological.Above-mentioned composition preferably comprises about 2% to about 50% emollient." emollient " used herein is meant and is used to the material that prevents or alleviate drying and be used to protect skin.Known have multiple suitable emollient, and can be used for herein.The 2nd edition the 1st volume of " Cosmetics, the Science and Technology " of Sagarin comprised many examples that are suitable for the material of making emollient in the 32nd to the 43rd page (1972).Preferred emollient is a glycerol.The consumption of glycerol is preferably about 0.001 to about 20% by the weight of described compositions, and more preferably from about 0.01 to about 15%, even more preferably from about 0.1 to about 10%.
The compositions of the present invention that can be used for cleaning (" cleaning agent ") is with suitable carrier (for example, aforesaid carrier, and comprise dermatological acceptable surfactant by the weight of described compositions about 1% to about 90%) preparation.
The physical form of Cleasing compositions is unimportant.Described compositions can be configured to and for example wash one's hands and face soap slab, liquid, shampoo, bath gels, conditioner, hair oil, paste or mousse.The washing soap slab is preferred, because this is the cleaning agent form that is most commonly used to washed skin.Washing-off type Cleasing compositions such as shampoo need be suitable for active substance with capacity and be deposited on delivery system on skin and the scalp.Preferred delivery system relates to the undissolved complex of use.The more complete disclosure of above-mentioned delivery system is found in United States Patent (USP) 4,835, in 148.
Compositions of the present invention also can be the cosmetics form.Suitable cosmetics form includes but not limited to foundation cream, lip pomade, kermes, mascara or the like.Above-mentioned cosmetics can comprise conventional composition, as oil, coloring agent, pigment, emollient, aromatic, wax, stabilizing agent etc.Be applicable to that the exemplary carrier of this paper and above-mentioned other composition for example are described in the United States Patent (USP) 6,060,547.
Compositions of the present invention can also be the formulation products form that shaves, and comprises example gel, foam, lotion and cream; And comprise aerosol and non-aerosol type.
Preparation of compositions
Compositions of the present invention is usually by conventional method preparation, the method for preparing topical compositions as known in the art.The said method typical case relates to the state that composition is mixed to the comparison homogeneous in one or more steps, can need or not need conditions such as heating, cooling, use vacuum.The described compositions of preferred for preparation is so that active agent stability (physical stability, chemical stability, light stability) and/or send optimum.This optimization can comprise suitable pH value (as, less than 7), get rid of can be with active substance compound and thereby negative effect stability or substance for delivery (as despumation ferrum), use method (as suitable dispersant or double casing) that the prevention complex generates, use suitable light stability method (as adding suntan lotion/sunscreen cream, using opaque packing) or the like.
Regulate the method for keratinous tissue conditions
Compositions of the present invention can be used for regulating numerous mammiferous keratinous tissue conditions.The adjusting of above-mentioned keratinous tissue conditions comprises preventative and therapeutic regulation.More particularly, above-mentioned control method relates to but is not limited to thicken collenchyme (promptly construct epidermal area and/or the skin corium and/or the hypodermic layer of skin, and under suitable situation, structure refers to/horny layer of toenail and hair shaft); By being used as blast skin or reducing Pigmented enamel and prevent, postpone and/or handle the uneven colour of skin; Prevention, postpone and/or handle the atrophy of mammal skin, softening and/or level and smooth mammiferous lip, hair and refer to/toenail; Prevention, delay and/or processing mammal skin pruritus; Prevention, delay and/or processing black eye and/or a swollen eye outward appearance; Prevention, delay and/or processing mammal colour of skin sallow; Prevention, delay and/or processing mammal skin sagging (being saccharification); Prevention and/or postpone that mammal skin is tanned, desquamation, decortication and/or increase renewal in the mammal skin; Reduce the pore size in the mammal skin; Regulate oiliness/glossy mammal skin outward appearance; Hyperpigmentation after prevention, delay and/or processing hyperpigmentation such as the inflammation; Spider shape blood vessel and/or erythema outward appearance on prevention, delay and/or the processing mammal skin; Prevention, delay and/or processing mammal skin microgroove and wrinkle; Prevention, postpone and/or handle xerosis cutis (promptly coarse, peel, peel off); And the scorching outward appearance of honeycomb in prevention, delay and/or the processing mammal skin.Compositions of the present invention also can be used for hair growth inhibition, reduce the shaving frequency, improve the shaving easiness, reduce the shaving frequency, make hair more soft and/or more very thin, make that hair is more unshowy, the hair regeneration that slows down long, reduce erythema and scytitis, make skin more smooth and/or more soft and improve the hair removing mode.The adjusting keratinous tissue conditions relates to the compositions of the present invention to the safe and effective amount of collenchyme local application.The amount of composition of being used, the frequency of using and life cycle will change widely according to skin in the given compositions and/or hair-care active substance and/or other components contents and required regulating degree.
In a preferred embodiment, described compositions chronic administration is in skin." long-term local application " be meant the experimenter in life, topical composition constantly for a long time, and the preferred time is at least about a week, more preferably at least about one month, even more preferably at least about three months, even more preferably at least about six months, and even more preferably at least about 1 year.Although beneficial effect still can obtain after the various maximum operating period (for example five, ten or 20 years), preferably use whole all the continuing for a long time in life of experimenter.In the time of above-mentioned continuity, the typical case according to every day rule approximately once use, yet frequency of administration can be weekly approximately to every day three times approximately or change in the scope more frequently.
The various consumptions of compositions of the present invention can be used to provide the beneficial effect of skin appearance and/or dermal sensation.With mg compositions/cm
2Skin meter, the typical amounts that compositions of the present invention is used at every turn are about 0.1mg/cm
2To about 20mg/cm
2The coating amount that is particularly useful is about 0.5mg/cm
2To about 10mg/cm
2
Preferably by use skin distillate medicinal water, cleaning lotion, emulsus lotion, cream, gel, foam, ointment, paste, emulsion, spray, conditioner, nourishing agent, cosmetics, lip pomade, foundation cream, refer to/nail polish, the compositions of form such as aftershave lotion carries out the adjusting of keratinous tissue conditions.Described compositions is intended to be retained on skin or other collenchyme, to reach beneficial effect some aesthetic, the prevention aspect, the treatment aspect or others (i.e. " leave " compositions).After using compositions on the collenchyme (as skin), it is stayed on the skin preferably at least about 15 minutes, more preferably at least about 30 minutes, even more preferably at least about 1 hour, even more preferably at least several hours, as about 12 hours at most.Can process facial, hair and/or refer to/any surperficial position of toenail for example face, lip, zone, eyelid, scalp, neck, trunk, arm, hands, lower limb, fingernail, toenail, hair of scalp, eyelashes, eyebrow etc. now.By for example using palm and/or finger, instrument (for example cotton balls, swab, liner, cleaning piece or the like), carry out using of compositions of the present invention.
Guarantee to the skin of major general's minimum content and/or hair-care active substance continuously coating be that the patch that is administered to by use on the face is for example used described chemical compound in another method on the collenchyme.Said method especially can be used for problematic skin area, the processing that described skin area needs more to strengthen (as facial crows-feet zone, place between the eyebrows stricture of vagina, zone etc. now).Described patch can be occlusion, half occlusion or not occlusion.Said composition can be comprised in the patch, or is coated on the skin before using patch.Described patch also comprises additional active substance, as is used for the chemical initiator of exothermic reaction, as described in the PCT application WO 9701313 those.Described patch also comprises energy source (as battery), for example to strengthen sending of skin and/or hair-care active substance and other activating agent (as ionotherapy).Patch applies retention time on collenchyme preferably at least about 5 minutes, more preferably at least about 15 minutes, and also more preferably at least about 30 minutes, even more preferably at least about 1 hour, even a kind of form of more preferably handling as night evening.
The another kind of method of enhanced activity material beneficial effect is to use has 2 kinds or 3 kinds or 4 kinds or more kinds of product and/or treatment step (as decortication, use one or more active substance Local treatment of the present invention afterwards, alopecia, use one or more active substance Local treatment of the present invention afterwards, or the like) cover box or embodiment.Can be in short time period (for example in one hour), or in the long period section in a day (for example morning and night), or even longer time period in (for example weekly or carried out in every month step in the embodiment, and carry out other step in the embodiment with more regularly benchmark (for example every day)), use the various components in the embodiment.Cover box or embodiment also comprise for example two or more cleaning agent of combination of above-mentioned carrier and/or product form, local leave handled thing and oral supplement.
The present invention also imagines via device to the collenchyme delivery of energy, energy send can with the using simultaneously and/or carry out in succession of topical compositions.The energy delivery apparatus can be sent the energy of various ways, includes but not limited to the energy of following form: light, heat, sound (comprising ultrasound wave), magnetic energy, electromagnetic energy (comprising rf wave and microwave) and their combination.Sending of energy can be successive, pulse, synthetic, non-modulation and their combination.In one embodiment, described energy delivery apparatus is a hand-held.Alternatively, described energy delivery apparatus is wireless.
By device being maintained in the single area of collenchyme, subsequently described device is moved to another zone (or " punching press ") of tissue, apply energy.Alternatively, can when described device moves continuously or scan by tissue surface, apply energy.When using laser aid, described device will keep basic Continuous Contact with the collenchyme surface, and perhaps when using flash lamp, described device and collenchyme keep short distance, and energy points to the surface simultaneously.
In collenchyme or alternatively, in the chemical compound on being administered to tissue surface, can produce variations in temperature simultaneously.This variations in temperature is the variation except that any variations in temperature that is produced by delivery of energy self.For example, can before energy is sent, collenchyme be heated slightly, or alternatively, after energy is sent, collenchyme be cooled off.
For for the energy of ultraviolet source, wavelength is usually located in the UV-A scope of about 315-400nm (nanometer).For for the energy of visible light source, wavelength usually at about 400nm to the scope of about 700nm.For for the energy of infrared (IR) light source, wavelength is extremely about to the scope of about 3000nm at about 700nm usually.The energy values of being sent or " output flow " can be at about 1J/cm
2To about 100J/cm
2Scope in, wherein " J " is meant joule.For light-pulse generator, pulse width about 0.001 second to about 3 seconds scope, the average pulse persistent period is about 0.001 second to about 1 second.Collenchyme surface area to be covered will change according to using.Send these and other relevant parameter with energy and depend on the type of processing and the type of pending tissue, and can come suitable selection by those skilled in the art.
Article of commerce
The present invention also provides article of commerce, described article of commerce comprises personal care composition, with at least a labelling (and/or image) relevant with the packing that is used for personal care composition, and the show and colour relevant with described personal care composition, described show and colour is passed on following information: the local application personal care composition can improve people's skin color or skin color.
In an exemplary, the packing that is used for personal care composition comprises labelling and/or image.Described packing can be main packing, less important packing and/or additional packing.The packaging type relevant with the present invention is nonrestrictive.Described packing can be made by multiple material, can be made into multiple configuration, but and the known any manufacturing technology of operation technique personnel make.Exemplary packing embodiment comprises box, sack, pouch, cardboard jar, bottle, tottle, wide mouthed bottle, heating shaping bubble-cap, Concha Meretricis Seu Cyclinae and their combination.Other packing embodiment suits equally.
In another exemplary, show and colour relevant with personal care composition and/or device comprise labelling and/or image.Exemplary show and colour/device includes but not limited to, point of sale device and/or material, sample and relevant information, rebate coupon, mail-mail advertising leaflet, regular promotional literature, product manual, product inset, product display, shelf card, bulletin, placard, bus, outdoor seat rest facility, and any other advertising media that can be obtained by possible buyer.For example, show and colour and/or device are can (forever or removably) fixing on the packaging, or are included in the packing.
Embodiment
It below is the non-limiting example of compositions of the present invention.Providing of embodiment only is the purpose that illustrates for example, should not be construed as limitation of the present invention, because under the situation that does not deviate from the spirit and scope of the present invention, its many changes are possible, and this will be recognized by those of ordinary skill in the art.In an embodiment, except as otherwise noted, all concentration are all listed with percentage by weight, side by side except minor materials, as diluent, filler etc.Therefore, listed preparation comprises listed component and any trace substance relevant with this component.It is evident that concerning the those skilled in the art of this area the selected of these accessory constituents will be according to the physics of selected concrete composition with chemical characteristic and different, to make invention as herein described.
| Content in the preparation (the component gram number in every 100g preparation) | ||||||
| Component | A | B | C | D | E | F |
| Disodiumedetate | 0.100 | 0.1 00 | 0.100 | 0.100 | 0.100 | 0.100 |
| Ergothioneine (is Thiotaine ) 1 | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 |
| The N-n acetylglucosamine n | 0 | 2.000 | 0 | 0 | 0 | 0 |
| N-endecatylene acyl-L-phenylalanine | 0 | 0 | 1.000 | 0 | 0 | 0 |
| Cetylpyridinium chloride | 0 | 0 | 0 | 0.200 | 0 | 0 |
| The own oxygen phenylate of dihydroxy ethyl sulfonic acid | 0 | 0 | 0 | 0 | 1.000 | 0 |
| Nicotiamide | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 | 5.000 |
| Citric acid | 1.500 | 0 | 0 | 0 | 0 | 0 |
| 2-Methylpentadecane | 3.000 | 3.000 | 0 | 0 | 3.000 | 3.000 |
| The isostearic acid isopropyl ester | 1.330 | 1.330 | 0 | 0 | 1.330 | 1.330 |
| N-Hamposyl L isopropyl ester | 0 | 0 | 5.000 | 6.000 | 0 | 0 |
| Poly-cottonseed acid sucrose ester | 0.670 | 0.670 | 0 | 0 | 0.670 | 0.670 |
| Poly methyl silsesquioxane | 0.250 | 0.250 | 0.250 | 0.250 | 0.250 | 0.250 |
| Cetearyl glucoside+16/octadecanol | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 |
| Docosanol | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 |
| Ethylparaben | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 | 0.200 |
| Propyl p-hydroxybenzoate | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 |
| Spermol | 0.320 | 0.320 | 0.320 | 0.320 | 0.320 | 0.320 |
| Stearyl alcohol | 0.480 | 0.480 | 0.480 | 0.480 | 0.480 | 0.480 |
| Tocopherol acetas | 0.500 | 0.500 | 0.500 | 0.500 | 0.500 | 0.500 |
| The PEG-100 stearate | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 | 0.100 |
| Glycerol | 7.000 | 7.000 | 7.000 | 7.000 | 7.000 | 7.000 |
| Titanium dioxide | 0.604 | 0.604 | 0.604 | 0.604 | 0.604 | 0.604 |
| Polyacrylamide+C13-14 isoparaffin+laureth-7 | 3.000 | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 |
| Pantothenylol | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 |
| Benzylalcohol | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 | 0.400 |
| Polydimethylsiloxane+dimethiconol | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 | 2.000 |
| Water (to 100g) | To 100 | To 100 | To 100 | To 100 | To 100 | To 100 |
| Amount to | 100 | 100 | 100 | 100 | 100 | 100 |
1 Thiotaine is the solution of ergothioneine, and ergothioneine content is 0.04% to 0.05%.
Although, it will be apparent to those skilled in the art that many other variations and modifications may be made in the case of without departing from the spirit and scope of protection of the present invention with specific embodiments explanation with described the present invention.Therefore, in additional claims, comprise all such changes and modifications that belong in the scope of the invention consciously.
The relevant portion of all documents of quoting in background of invention, summary of the invention and the detailed Description Of The Invention is incorporated herein by reference.The quoting and may not be interpreted as of any document to its approval as prior art of the present invention.
Claims (13)
1. personal care composition, described compositions comprises:
(a) ergothioneine;
(b) at least a additional skin and/or hair-care active substance, described active substance is selected from the group of being made up of following material: osamine, primoline chemical compound, N-acyl amino acid compound, cetylpyridinium chloride and their combination; With
(c) dermatological acceptable carrier.
2. personal care composition as claimed in claim 1, wherein said at least a additional skin and/or hair-care active substance are osamine, described osamine comprises the N-acetyl glucosamine.
3. personal care composition as claimed in claim 1, wherein said at least a additional skin and/or hair-care active substance are N-acyl amino acid compound, described chemical compound comprises N-endecatylene acyl-L-phenylalanine.
4. as each described personal care composition in the claim 1 to 4, described compositions also comprises annexing ingredient, and described annexing ingredient is selected from the group of being made up of following material: desquamation active substance, anti-acne active substance, wrinkle repairing activity material, antioxidant, free radical scavenger, chelating agen, flavonoid, antiinflammatory, the scorching agent of anti-cellulite, skin lightening agent, anti-microbial active matter, antifungus active substance, conditioner, thickening agent, water soluble vitamins, fat soluble vitamin, particulate matter, local anesthetic and their combination.
5. personal care composition, described compositions comprises:
(a) ergothioneine;
(b) N-acyl amino acid compound;
(c) nicotiamide;
(d) pantothenylol;
(e) vitamin e acetate; With
(f) dermatological acceptable carrier.
6. personal care composition as claimed in claim 5, described compositions also comprise deoxidation benzene ratio and want chemical compound.
7. as claim 5 or 6 described personal care compositions, described compositions also comprises osamine.
8. personal care composition as claimed in claim 7, wherein said osamine comprises the N-acetyl glucosamine.
9. as each described personal care composition in the claim 5 to 8, wherein said N-acyl amino acid compound is N-endecatylene acyl-L-phenylalanine.
10. as each described personal care composition in the claim 5 to 9, described compositions also comprises annexing ingredient, and described annexing ingredient is selected from the group of being made up of following material: desquamation active substance, anti-acne active substance, wrinkle repairing activity material, antioxidant, free radical scavenger, chelating agen, flavonoid, antiinflammatory, the scorching agent of anti-cellulite, skin lightening agent, anti-microbial active matter, antifungus active substance, conditioner, thickening agent, water soluble vitamins, fat soluble vitamin, particulate matter, local anesthetic and their combination.
11. a method of regulating skin color or skin color, described method comprises the step to target skin area local application personal care composition as claimed in claim 1.
12. the method for a prevention, delay and/or processing mammal skin sallow, described method comprises the step that comprises the personal care composition of ergothioneine to the local application of target skin area.
13. a prevention, postpone and/or handle the method for erythema outward appearance on the mammal skin, described method comprises the step that comprises the personal care composition of ergothioneine to the local application of target skin area.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68162605P | 2005-05-17 | 2005-05-17 | |
| US60/681,626 | 2005-05-17 | ||
| US11/406,471 | 2006-04-18 |
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| Publication Number | Publication Date |
|---|---|
| CN101175471A true CN101175471A (en) | 2008-05-07 |
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| CNA2006800169189A Pending CN101175467A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169259A Pending CN101175469A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA200680016867XA Pending CN101175471A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800168684A Pending CN101175472A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169244A Pending CN101175468A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
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| CNA2006800169189A Pending CN101175467A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
| CNA2006800169259A Pending CN101175469A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
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| CNA2006800169244A Pending CN101175468A (en) | 2005-05-17 | 2006-05-17 | Regulation of mammalian keratinous tissue using personal care compositions comprising diethylhexyl syringylidene malonate |
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| CN105982890A (en) * | 2014-09-05 | 2016-10-05 | 中国医药大学 | Use of ergothioneine for activating the Nrf2 signaling pathway of cells |
| CN110742822A (en) * | 2019-12-11 | 2020-02-04 | 广州环亚化妆品科技有限公司 | Skin whitening anti-aging composition, whitening anti-aging cream containing same and preparation method thereof |
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| CN102573777A (en) * | 2009-10-29 | 2012-07-11 | 宝洁公司 | Transparent cosmetic composition |
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2006
- 2006-05-17 CN CNA2006800169189A patent/CN101175467A/en active Pending
- 2006-05-17 CN CNA2006800169259A patent/CN101175469A/en active Pending
- 2006-05-17 CN CNA200680016867XA patent/CN101175471A/en active Pending
- 2006-05-17 CN CNA2006800168684A patent/CN101175472A/en active Pending
- 2006-05-17 CN CNA2006800169244A patent/CN101175468A/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101175472A (en) | 2008-05-07 |
| CN101175469A (en) | 2008-05-07 |
| CN101175468A (en) | 2008-05-07 |
| CN101175467A (en) | 2008-05-07 |
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