KR20060104178A - The cosmetic composition for skin whitening - Google Patents

Abstract

The present invention provides a cosmetic composition for whitening containing cornus oil, goji berry, bokbunja, haesongja, pearl powder extract.

The cosmetic composition for whitening of the present invention has an effect of inhibiting tyrosinase activity, has an effect of inhibiting melanin production, and is low in cytotoxicity and thus is safe due to no skin irritation, and thus may be usefully used in cosmetics for skin whitening.

Description

Whitening cosmetic composition {The cosmetic composition for skin whitening}

The present invention relates to a cosmetic composition for whitening containing cornus oil, goji berry, bokbunja, haesongja, pearl powder extract as an active ingredient.

Generally, the skin's epidermis becomes black when the skin is exposed to ultraviolet rays. This is due to the synthesis and release of melanin in melanocytes, which produce 3,4-dihydroxy by oxidizing L-tyrosine, a substrate of tyrosinase in cells. It produces phenylalanine (L-DOPA) from which dopaquinones are produced, and melanin synthesis is achieved by spontaneous oxidation from this dopaquinone.

Therefore, in order to prevent skin blackening, a method of reducing melanin production by inhibiting the tyrosinase activity or inhibiting some reactions in the melanogenesis process is the simplest and most common.

Many natural and synthetic substances are known as tyrosinase inhibitors, and some are used as skin lightening agents. Examples include linoleic acid, hinokitiol, kojic acid, hydroquinone, ascorbic acid, glutathione, epidermis extract, arbutin Various materials have been used.

Among them, ascorbic acid, baekryepi extract, glutathione, etc. have been used for the treatment of skin blackening or skin disease, but has been limited in the safety of the skin and the stability of the cosmetic formulation. In addition, hydroquinone is already used as a drug for the purpose of treating blemishes, but it has been prescribed as a skin irritant and carcinogenic substance. Ascorbic acid is difficult to apply the product because of the high cost to obtain the problems and effects of stability to light and heat.

Cornus officinalis SIEB. Et ZUCC. Is a dried fruit of cornus, Morroniside, Loganin, It contains glycosides such as tannin and saponin and organic acids such as wine acid, apple acid, and tartaric acid. Vitamin A and a large amount of sugar are also included. Seeds contain palmitic acid, oleic acid, linoleic acid, and the like. Among the components, cornine is known to have an excitatory action of parasympathetic nerves.

From ancient times, medicinal herbs are medicinal, and it is known that they are effective in gangeum (신), Sinjeong (腎精) and Shingi (腎氣) reinforcement, convergence. It is used as a medicine for headache, tinnitus, seawater disease, fever and excessive menstruation. It is also used for cold sweats and nocturnal enuresis.

Gugija is a dried fruit of Lycium chinense Miller. Its main active ingredients are betain, zeaxanthin, beta-sitosterol, and physalin. Choline, rutin and protein, fat, sugars, calcium, phosphorus, iron, vitamins (A, B1, B2, C), and more. In oriental medicine, it is used as a tonic and antipyretic. It is known to improve vision, prevent adult diseases such as diabetes, improve lung and kidney function, and weaken the constitution. In addition, goji berry extract has been reported to have antioxidant activity (Kim et al., Korean Journal of Food Preservation , 11 (3), pp352-357, 2000).

In addition, bokbunja medicinal immature fruit of the bokbunja strawberry ( Rubus coreanus Miquel), contains anthocyanin, polyphenol, carotene, cyanide glycoside, pigment, etc., vitamin B, C, E and lemon acid, It contains organic acids such as malic acid, salicylic acid and capronic acid. Carbohydrates contain 43% of glucose, 8% of fructose, 6.5% of sucrose, and also contain pectin. Bokbunja has long been known to be effective in interpolating, nominal, and diuretic drugs, and has been known to treat energetic decline, oil wells, and urinary frequency.

Haisongja is the name of pine in Chinese medicine. The ingredient contains 74% fatty oil and 15% protein, and the fat contains unsaturated fatty acids such as oleic acid, linoleic acid and linoleic acid. And it is effective in preventing aging and adult diseases such as atherosclerosis, senile diseases.

Korean Unexamined Patent Publication No. 1997-21273 discloses a whitening soap composition containing an extract of baekryepi or cornus milk, which has a tyrosinase inhibitory effect, and Korean Unexamined Patent Publication No. 2002-44267 discloses a whitening cosmetic composition mainly comprising bokbunja extract. In addition, Korean Laid-Open Patent Publication No. 1998-26114 discloses a cosmetic beverage composition containing a freshwater pearl extract, which is excellent in inhibiting the production of melanin, blemishes, freckles, and the like.

As disclosed in the above document, when each single extract component is used in a cosmetic composition, problems such as lowering whitening effect, lack of stability according to manufacturing techniques, or causing skin troubles occur.

Accordingly, the present inventors have completed the present invention by confirming that the components extracted from the mixture of plant fruit and natural products have excellent whitening effect as a result of studying various kinds of plants and natural products to obtain a whitening effect.

Accordingly, the present invention is to provide a cosmetic composition for whitening, containing cornus oil, goji berry, bokbunja, haesongja, pearl powder extract as an active ingredient.

The present invention provides a cosmetic composition for whitening, containing cornus oil, wolfberry, bokbunja, Haesongja, pearl powder extract as an active ingredient.

Cornus oil, wolfberry, bokbunja, Haesongja, pearl powder extract used in the cosmetic composition for whitening of the present invention is a dry weight ratio of 1 to 30: 1 to 30: 1 to 30: 1 to 30: 1 to 30, preferably 1: It is extracted by mixing in a dry weight ratio of 1: 1: 1: 1.

In addition, the extract contained in the cosmetic composition for whitening of the present invention, may be a wild extract, gojijaja, bokbunja, haesongja, crude extract of a non-polar solvent and a non-polar solvent soluble extract, a polar solvent soluble extract, among which is cornus, wolfberry, bokbunja It is preferable to use ethanol extracts of pine, pine, and pearl powder.

The cosmetic composition for whitening of the present invention preferably contains 0.001 to 10.00 parts by weight of cornus oil, wolfberry, bokbunja, sea songja, pearl powder extract, and 0.01 to 1.00 parts by weight based on the total weight. When cornus oil, wolfberry, bokbunja, haesongja, pearl powder extract is contained in less than 0.001 parts by weight relative to the total weight, it is difficult to obtain a whitening effect, when contained in more than 10.00 parts by weight, the whitening effect is reduced compared to the content and the manufacturing cost increases do.

The composition containing the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract of the present invention is superior to arbutin in inhibiting tyrosinase enzyme activity involved in skin blackening process, and at the same time, the rate of melanin production in B16 melanoma cells is higher than that of arbutin. The effect is excellent.

In addition, the composition containing the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract of the present invention shows an excellent whitening effect than the conventional cornus oil, bokbunja, pearl powder extract, because it is safe and does not irritate the skin due to low cytotoxicity It can be usefully used in cosmetics for skin whitening.

Extracts contained in the cosmetic composition of the present invention can be prepared as follows.

The extract contained in the cosmetic composition for whitening of the present invention, after washing the fruit and pearls, including cornus, goji berry, bokbunja, sea squid clean with water, the usual drying method, preferably natural drying, and the dried product Or prepared in powder form and then extracted the active ingredient in a conventional extraction method.

Corn oil, Goji berries, Bokbunja, Sea Songja, Pearl powder = dry weight ratio of 1 ~ 30: 1 ~ 30: 1 ~ 30: 1 ~ 30: 1 ~ 30 before extraction, preferably 1 ~ 10: 1 ~ 10: 1 ~ 10 : 1-5: can be mixed and extracted in a dry weight ratio of 1-5, and each extract can be prepared and used in a mixture ratio as described above.

The extract of the cornus oil, wolfberry, bokbunja, haesongja, pearl powder crude oil of the present invention, finely divided or powdered cornus, wolfberry, bokbunja, haesongja, water of about 3 to 20 times the weight of dried fruit powder, C ₁ to C ₄ Lower alcohol having carbon number or a mixed solvent thereof, preferably ethanol, by extraction method such as hot water extraction, cold sediment extraction, ultrasonic extraction or reflux cooling extraction for about 6 to 48 hours at an extraction temperature of room temperature to 100 ° C. After repeated extraction once to three times, the extract may be prepared by filtration, concentrated under reduced pressure or lyophilized.

In addition, the crude extract may be suspended in water, and then fractionated 1 to 5 times by adding about 0.5 to 10 times the suspension and a polar or nonpolar solvent to obtain a polar or nonpolar solvent-soluble extract of the present invention. It is also possible to carry out further conventional fractionation processes.

The polar solvent includes water, ethanol, butanol, acetone, and the like, and the nonpolar solvent includes ethyl acetate, chloroform, hexane, benzene, dichloromethane and the like.

In addition, the cornus oil, wolfberry, bokbunja, haesongja, pearl powder extract of the present invention, the step of extracting the fine or powdered mixed dried with ethanol, the step of drying the precipitate after removing the supernatant extracted with ethanol, see the dried product Milling (ball milling) to finely grind, distilled water is added to the pulverized product, followed by filtration and distillation under reduced pressure, ethanol is added to the extract of the step to induce precipitation, and the precipitate is freeze-dried after centrifugation. To remove the dried extract 15% TCA (trichloroacetic acid) by adding a protein, the supernatant of the step may be prepared by lyophilizing after precipitation with ethanol.

The cosmetic composition for whitening of the present invention may contain cosmetically acceptable bases and additives as needed in addition to the active ingredients described above, for example, moisturizers, fats and oils, emulsifiers, softeners, lubricants conventional in the art. , Solvents, dissolution aids, thickeners, pH adjusters, preservatives, fragrances, pigments, UV blockers and the like may further include components, and their types and contents may be easily selected by those skilled in the art.

Moisturizers include one or two of the existing moisturizing ingredients such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, sorbitol, and collagen. The above can be mixed and used.

Examples of the oil and fat components include ester fats, hydrocarbon fats, silicone fats, fluorine fats, animal fats, and vegetable fats and oils. Isopropyl myristate, isostearyl-isostearate, glyceryl monostearate, squalene, and fluids Paraffin and the like.

The emulsifier may specifically be tween 20 (polyoxyethylene sorbitan fatty acid ester).

Softeners and lubricants may specifically be cyclomethicone, polymethyl methacrylate, and hydrogenated castor oil.

Specifically, the solvent may be purified water, lower alcohols such as ethanol, higher alcohols such as cetyl alcohol, mixed liquids thereof, and the like.

Dissolution aids may specifically be isopropyl myristate, polyethylene glycol, medium chain fatty acid triglycerides, hydrocarbons, glycols, and the like.

Thickeners include methyl cellulose, carboxymethyl cellulose, carboxymethyl hydroxyguanine, hydroxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, cocamide die, polyquaternium, cetearyl alcohol, stearic acid, carrageenan, and the like. Can be.

Specifically, the pH adjuster may be any of organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid, glycolic acid, and inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, nitric acid, sodium salts of these acids, Potassium salt, ammonium salt, etc. can be used in combination, A triethanolamine, sodium hydroxide, potassium hydroxide, etc. can also be used.

Preservatives may specifically be imidazolidinyl urea, methyl parabens, propylparabens and the like.

As the fragrance, artificial fragrance or the like can be used.

The cosmetic composition excellent in the whitening effect according to the present invention can be used in a variety of cosmetics, face wash, detergent, shampoo, etc., and may have a conventional formulation, for example, supple cosmetics, astringent cosmetics, nutrient cosmetics, nutrition cream, essence It can be formulated as a skin patch, pack, systemic cleaner, body lotion, body oil, body essence and the like.

In addition, the cosmetic composition excellent in the whitening effect according to the present invention can be used according to a conventional method of use, the number of times of use can be varied according to the user's skin condition or taste.

Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are merely provided to more easily understand the present invention, and the contents of the present invention are not limited by the examples.

EXAMPLES Preparation of the cosmetic composition for whitening of this invention

1) Preparation of extract contained in the composition of the present invention

Cornus, wolfberry, Bokbunja, Haesongja and Pearl powder extracts were prepared to prepare the composition of the present invention.

1-1) Extract Preparation 1

Cornus, wolfberry, bokbunja, haesongja, pearl powder was washed thoroughly with water and then completely dried. Each raw material was mixed in a weight ratio of 1: 1: 1: 1: 1 and ground. The extract obtained by cold sedimentation was repeated twice over 12 hours with ethanol of 10 times to dry weight 100 g, filtered and concentrated, and then freeze-dried to obtain 7 g of crude extract.

1-2) Extract Preparation 2

Cornus oil, gojijaja, bokbunja, haesongja, pearl powder mixed pulverized product of 1-1) is reflux-cooled with 10 times ethanol for 24 hours with respect to a dry weight of 10g, the supernatant extracted with ethanol was removed and the precipitate was dried. .

The precipitate obtained above was degreased, which was ball milled for 48 hours, finely ground to have a particle size of about 10 to 50 μm, and then used in the next step.

Five times distilled water was added to the pulverized product, and reflux-cooled extracted three times for 6 hours, followed by filtration. After distillation under reduced pressure, only a small amount of water remained, ethanol was added to induce precipitation, and the precipitate was freeze-dried after centrifugation.

15% TCA (trichloroacetic acid) was added to the dried sample obtained to precipitate and remove the protein. The supernatant was precipitated with ethanol and freeze-dried to obtain 3 g of a water extract.

1-3) Extract Preparation 3

The crude extract of Example 1-1) was suspended in 50 ml of distilled water, and then 50 ml of ethyl acetate was added and mixed. The operation of dividing into an aqueous layer and an ethyl acetate layer was repeated three times, and the aqueous layer and the ethyl acetate layer were concentrated under reduced pressure to obtain 5 g of a water extract and 2 g of an ethyl acetate extract.

1-4) Extract Preparation 4

The cornus oil was washed thoroughly with water and then completely dried. This was pulverized, and extracted twice with reflux cooling extraction method for 10 hours with 10 times ethanol to dry weight 10 g. The obtained extract was filtered, concentrated and freeze-dried to obtain 0.15 g of crude extract.

Wolfberry, Bokbunja, Haesongja and Pearl powder were extracted, filtered, concentrated and lyophilized using the same method as above to obtain crude extracts of 0.13 g, 0.16 g, 0.10 g and 0.04 g, respectively.

A mixture of each extract in a ratio of 1: 1: 1: 1: 0.2 was used in addition to the cosmetic composition for whitening.

2) Determination of Tyrosinase Activity Inhibitory Effect of the Extract of the Present Invention

In order to confirm the inhibitory effect of tyrosinase activity using the extracts obtained in Examples 1-1) and Examples 1-2), the method described in the literature, such as No. JK, was measured by modifying (No. JK, et al .; Life Science , 65 , p241-246, 1999).

As a positive control group, arbutin, an existing whitening ingredient, was used.

In addition, the extracts prepared by the method of Example 1-1) and Example 1-2) using whole plants (including roots, stems, and fruits) and pearl powder having cornus, wolfberry, bokbunja, and pine needles were compared, respectively. Examples 1 and 2 were used, and the extract prepared by the method of Example 1-1) using a mixture of three natural products of cornus, bokbunja and pearl powder was used as Comparative Example 3.

First, 1 ml of 0.3 mg / ml tyrosine solution was added to the test tube, and 1 ml of 0.1 M potassium phosphate buffer (pH 6.8) and the sample according to the concentration of the extract (0.07, 0.1, 0.5, 1.0 (%, W / V)). ) 0.9 ml was added and reacted in a 25 ° C. thermostat for 10 minutes. In this case, only 0.9 ml of the solvent was used instead of each sample as a control. 0.1 ml each of 2500 units / ml of tyrosinase enzyme was added to the reaction solution, and then reacted in a 25 ° C. thermostat for 10 minutes.

The test tube containing the reaction solution was placed in iced water, quenched to stop the reaction, and the absorbance at 475 nm was measured with a photoelectric spectrometer. The tyrosinase activity inhibitory effect of each sample was calculated by the following formula, and the results are shown in Table 1.

* Tyrosinase activity inhibition rate (%) = 100- (response absorbance of each sample / control absorbance of control) × 100

 sample IC ₅₀ (%) Example 1-1) 0.26 Example 1-2) 0.23 Arbutin 0.40 Comparative Example 1 0.35 Comparative Example 2 0.31 Comparative Example 3 0.37

As seen above, the tyrosinase activity 50% inhibitory concentration (IC ₅₀ ) of the extracts of Examples 1-1) and 1-2) of the present invention was much lower than that of the arbutin-treated group and Comparative Examples 1, 2, and 3, which were positive controls. appear.

Therefore, it was found that the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract contained in the cosmetic composition for whitening of the present invention is excellent in tyrosinase inhibitory effect even at low concentration, and excellent in whitening effect.

The composition containing the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract of the present invention was found to exhibit an excellent whitening effect than the conventional cornus oil, bokbunja, pearl powder extract.

3) Determination of the melanin production inhibitory effect of the extract of the present invention

In order to confirm the melanin production inhibitory effect of the extract obtained in Example 1-1) and Example 1-2), it was measured using the method described in the literature, such as furnace (JS Roh, et al .; Biol. Pharm Bull. , 27 , p1976-1978, 2004).

Cells were B16 melanoma and 5000 cells / well B16 melanoma cells were dispensed in 96-well microplates, and after 24 hours the extracts were concentrated by concentration (0.0025, 0.005, 0.01, 0.025 (%, W / V), respectively. ) And incubated for 72 hours.

In order to extract melanin from the cells separated from the culture vessel by trypsin treatment after culturing, the cells were mixed with 10% DMSO and 1N NaOH, left at room temperature for 10 minutes, and after centrifugation, the amount of melanin in the supernatant was absorbed at 475 nm. Was measured.

The control group was measured at the same time only with the cells without the extract and the medium, and the same amount of the medium was used instead of the extract. The positive control group was used arbutin, the extract prepared in Example 2) was used as Comparative Examples 1 to 3.

The results were measured by comparing the cytotoxicity of the sample and the melanin production inhibitory effect in the concentration range without the cytotoxicity and considering the number of cells, and shown in Table 2 below.

* Melanin production inhibition rate (%) = {(control-experiment) / control} × 100

Melanin production inhibition rate (%)  Treatment concentration sample ＼ 0.0025% 0.005% 0.01% 0.025% Example 1-1) 12.5 21.2 24.3 25.1 Example 1-2) 10.3 20.1 19.3 19.4 Arbutin 9.8 15.0 20.3 14.1 Comparative Example 1 9.9 15.4 19.2 14.5 Comparative Example 2 9.8 15.3 19.1 14.5 Comparative Example 3 10.1 15.6 19.4 15.7

Looking at the results of Table 5, it was confirmed that the melanin production inhibitory effect of the extract of Examples 1-1) and 1-2) is superior to the positive control group (arbutin) and Comparative Examples 1, 2, 3, cornus milk of the present invention, The composition containing gojija, bokbunja, haesongja, pearl powder extract was found to be excellent whitening effect.

4) Cytotoxicity Test of the Extract of the Present Invention

Cytotoxicity of the extract of the present invention was measured by MTT assay.

The B16 melanoma cells (1 × 10 ⁵ cells) were incubated in 96-well microplates using Eagle Minimal Media. After incubating the cells for 24 hours at 37 ° C. and 5% CO ₂ -95% atmosphere, the crude extract of Example 1-1) dissolved in DMSO was treated in culture medium at various concentrations. After 48 hours of incubation, cytotoxicity was observed through MTT color analysis using tetrazolium. Absorbance (OD) was measured using an ELISA reader at 540 nm.

As a result, the cytotoxicity of the crude extract of Example 1-1 was measured to be LD ₅₀ 100 µg / ml or more, showing no cytotoxicity, and the composition containing the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract of the present invention. Confirmed that it can be used safely. Arbutin LD ₅₀ was measured at 150 μg / ml or more.

5) Preparation of the cosmetic composition for whitening of the present invention: skin lotion

A whitening cosmetic composition containing the extract of the present invention having the inhibitory effect on tyrosinase activity and melanin production was prepared.

A skin lotion was prepared at the composition ratio as shown in Table 3 below.

The alcohol part was prepared by dissolving methylparahydroxybenzoic acid (MP), tween 20, and nonylphenylether-12 (NP-12) in alcohol produced at 78 ° C. and distilled at 78 ° C., and the purified water part was sterilized. After preparing and dissolving glycerin, 1,3-butylene glycol, alanine 193, citric acid and sodium citrate in purified water, the extract prepared in Example 1-1) was mixed to prepare a skin lotion.

Classification Raw material name Weight (part by weight) Alcohol part ethanol 7 Methylparahydroxybenzoic acid 0.1 tween-20 0.2 Nonylphenylether-12 0.2 Purified water Purified water 90.51 glycerin 0.65 1,3-butylene glycol 0.2 Alanine 193 0.1 Citric acid 0.01 Citric acid 0.03 Whitening ingredients Example 1-1) Extract 1.0 Sum 100

Example 2 Preparation of Whitening Skin Lotion of the Present Invention 2

A skin lotion was prepared at the composition ratio as shown in Table 4 below. The alcohol part was produced by dissolving in the order of MP, tween 20, NP-12 in alcohol distilled at 78 ° C in the order of grain, and the purified water part was glycerin, 1,3-butylene glycol, alanine-193 in sterilized purified water. Prepared by dissolving in the order of citric acid, sodium citrate, and then the extract prepared in Example 1-2) to prepare a skin lotion.

Classification Raw material name Weight (part by weight) Alcohol part ethanol 7 Methylparahydroxybenzoic acid 0.1 tween-20 0.2 Nonylphenylether-12 0.2 Purified water Purified water 90.51 glycerin 0.65 1,3-butylene glycol 0.2 Alanine 193 0.1 Citric acid 0.01 Citric acid 0.03 Whitening ingredients Example 1-2) Extract 1.0 Sum 100

Example 3 Preparation of Whitening Milk Croissant of the Present Invention 3

Milk lotion was prepared at a composition ratio as shown in Table 5 below.

The alcohol fraction is produced from grains and distilled from 78 ° C to stearic acid, cetanol, liquid paraffin, squalene, isopropyl myristate, glyceryl monostearate, aracel-60, tween-20, isostearyl-isostearate , Propylparaben, alanine was prepared by dissolving 200F / 100CS in order, the purified water portion was prepared by dissolving in the order of glycerin, triethanolamine, propylene glycol, methyl parahydroxybenzoic acid in the sterilized purified water Example 1 Milk lotion was prepared by mixing the extract prepared in -1).

Classification Raw material name Weight (part by weight) Alcohol part Stearic acid 2.1 Cetanol 1.3 Liquid paraffin 7.0 Squalene 0.5 Isopropyl myristate 1.0 Glyceryl Monostearate 0.5 Arasel-60 0.85 tween-20 0.1 Isostearyl-isostearate 0.5 Propylparaben 0.1 Alanine 200F / 100CS 0.1 Purified water Purified water 74.15 Triethanolamine 0.7 Propylene glycol 7.0 glycerin 3.0 Methylparahydroxybenzoic acid 0.1 Whitening ingredients Example 1-1) Extract 1.0 Sum 100

Example 4 Preparation of Whitening Mill Lotion of the Present Invention 4

Milk lotion was prepared at a composition ratio as shown in Table 6 below.

The alcohol fraction is produced from grains and distilled from 78 ° C to stearic acid, cetanol, liquid paraffin, squalene, isopropyl myristate, glyceryl monostearate, aracel-60, tween-20, isostearyl-isostearate , Propylparaben, alanine was prepared by dissolving 200F / 100CS in order, the purified water portion was prepared by dissolving in the order of glycerin, triethanolamine, propylene glycol, methyl parahydroxybenzoic acid in the sterilized purified water Example 1 Milk lotion was prepared by mixing the extract prepared in -2).

Classification Raw material name Weight (part by weight) Alcohol part Stearic acid 2.1 Cetanol 1.3 Liquid paraffin 7.0 Squalene 0.5 Isopropyl myristate 1.0 Glyceryl Monostearate 0.5 Arasel-60 0.85 tween-20 0.1 Isostearyl-isostearate 0.5 Propylparaben 0.1 Alanine 200F / 100CS 0.1 Purified water Purified water 74.15 Triethanolamine 0.7 Propylene glycol 7.0 glycerin 3.0 Methylparahydroxybenzoic acid 0.1 Whitening ingredients Extract of Example 1-2) 1.0 Sum 100

As mentioned above, cornus oil, goji berry, bokbunja, haesongja, pearl powder extract contained in the cosmetic composition for whitening of the present invention is excellent in tyrosinase enzyme inhibitory activity, excellent in inhibiting melanin production, low cytotoxicity to the skin It is safe due to no irritation and can be usefully used in cosmetics for skin whitening.

Claims (4)

A cosmetic composition for whitening containing cornus oil, wolfberry, bokbunja, haesongja, pearl powder extract as an active ingredient. The whitening cosmetic according to claim 1, wherein the cornus oil, goji berry, bokbunja, haesongja, pearl powder extract is mixed and extracted in a dry weight ratio of 1 to 30: 1 to 30: 1 to 30: 1 to 30: 1 to 30 Composition. The cosmetic composition for whitening according to claim 1 or 2, wherein the extract is an ethanol extract. The cosmetic composition for whitening according to claim 1, comprising 0.001 to 10.00 parts by weight of cornus oil, wolfberry, bokbunja, haesongja, pearl powder extract based on the total weight of the composition.