KR20060092220A - 유도성 ｎｏ-신타아제 저해제로서의 이미다조피리딘 유도체 - Google Patents
유도성 ｎｏ-신타아제 저해제로서의 이미다조피리딘 유도체 Download PDFInfo
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- KR20060092220A KR20060092220A KR1020067005873A KR20067005873A KR20060092220A KR 20060092220 A KR20060092220 A KR 20060092220A KR 1020067005873 A KR1020067005873 A KR 1020067005873A KR 20067005873 A KR20067005873 A KR 20067005873A KR 20060092220 A KR20060092220 A KR 20060092220A
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- GRJHONXDTNBDTC-UHFFFAOYSA-N phenyl trifluoromethanesulfonate Chemical compound FC(F)(F)S(=O)(=O)OC1=CC=CC=C1 GRJHONXDTNBDTC-UHFFFAOYSA-N 0.000 description 1
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- WWTULTKUWBKVGV-UHFFFAOYSA-M potassium;3-methoxy-3-oxopropanoate Chemical compound [K+].COC(=O)CC([O-])=O WWTULTKUWBKVGV-UHFFFAOYSA-M 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- ZZYXNRREDYWPLN-UHFFFAOYSA-N pyridine-2,3-diamine Chemical class NC1=CC=CN=C1N ZZYXNRREDYWPLN-UHFFFAOYSA-N 0.000 description 1
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- 239000002516 radical scavenger Substances 0.000 description 1
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- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03022053.7 | 2003-10-01 | ||
| EP03022053 | 2003-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060092220A true KR20060092220A (ko) | 2006-08-22 |
Family
ID=34384571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067005873A Withdrawn KR20060092220A (ko) | 2003-10-01 | 2004-09-30 | 유도성 ｎｏ-신타아제 저해제로서의 이미다조피리딘 유도체 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7468377B2 (https=) |
| EP (1) | EP1675854B1 (https=) |
| JP (1) | JP2007507467A (https=) |
| KR (1) | KR20060092220A (https=) |
| CN (1) | CN100415745C (https=) |
| AT (1) | ATE399169T1 (https=) |
| AU (1) | AU2004276015A1 (https=) |
| BR (1) | BRPI0414972A (https=) |
| CA (1) | CA2540083A1 (https=) |
| DE (1) | DE602004014630D1 (https=) |
| EA (1) | EA010261B1 (https=) |
| ES (1) | ES2309567T3 (https=) |
| IL (1) | IL173895A0 (https=) |
| MX (1) | MXPA06003349A (https=) |
| NO (1) | NO20061344L (https=) |
| NZ (1) | NZ546437A (https=) |
| RS (1) | RS20060196A (https=) |
| WO (1) | WO2005030771A1 (https=) |
| ZA (1) | ZA200601642B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2308260T3 (es) | 2003-10-01 | 2008-12-01 | Nycomed Gmbh | Derivados de imidazopiridinas como inhibidores de no-sintasa inducible. |
| US7317021B2 (en) | 2003-10-01 | 2008-01-08 | Altana Pharma Ag | Aminopyridine-derivatives as inductible no-synthase inhibitors |
| DE602004014523D1 (de) | 2003-10-01 | 2008-07-31 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| JP2007507467A (ja) * | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 |
| UY29825A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 3h-imidazol-(4,5 b (beta))piridina-2-il benzoatos y benzamidas, composiciones farmacéuticas que los contienen y aplicaciones |
| UY29823A1 (es) * | 2005-10-03 | 2007-05-31 | Astrazeneca Ab | Derivados sustituidos de 7-cloro-3h-imidazol-(4,5-b) piridina, composiciones farmacéuticas que los contienen, procesos para la preparación de los mismos y aplicaciones |
| WO2012033149A1 (ja) * | 2010-09-10 | 2012-03-15 | 塩野義製薬株式会社 | Ａｍｐｋ活性化作用を有するヘテロ環縮合イミダゾール誘導体 |
| GB201512635D0 (en) | 2015-07-17 | 2015-08-26 | Ucl Business Plc | Uses of therapeutic compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| GB8307865D0 (en) * | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| SE512835C2 (sv) | 1996-01-08 | 2000-05-22 | Astrazeneca Ab | Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare |
| AUPP873799A0 (en) * | 1999-02-17 | 1999-03-11 | Fujisawa Pharmaceutical Co., Ltd. | Pyridine compounds |
| ES2300599T3 (es) * | 2002-03-27 | 2008-06-16 | Nycomed Gmbh | Derivados de alcoxipiridina. |
| AU2003280578A1 (en) * | 2002-10-30 | 2004-05-25 | Ajinomoto Co., Inc. | Heterocyclic compounds |
| ES2308260T3 (es) * | 2003-10-01 | 2008-12-01 | Nycomed Gmbh | Derivados de imidazopiridinas como inhibidores de no-sintasa inducible. |
| US7317021B2 (en) | 2003-10-01 | 2008-01-08 | Altana Pharma Ag | Aminopyridine-derivatives as inductible no-synthase inhibitors |
| DE602004014523D1 (de) | 2003-10-01 | 2008-07-31 | Nycomed Gmbh | Imidazoä4,5-büpyridinderivate als inhibitoren der induzierbaren no-synthase |
| JP2007507467A (ja) * | 2003-10-01 | 2007-03-29 | アルタナ ファルマ アクチエンゲゼルシャフト | 誘導性ｎｏシンターゼ阻害剤としてのイミダゾピリジン誘導体 |
| BRPI0414873A (pt) | 2003-10-01 | 2006-12-12 | Altana Pharma Ag | derivados de imidazopiridina como inibidores de no-sintase induzìveis |
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2004
- 2004-09-30 JP JP2006530264A patent/JP2007507467A/ja not_active Withdrawn
- 2004-09-30 NZ NZ546437A patent/NZ546437A/en unknown
- 2004-09-30 CN CNB2004800275920A patent/CN100415745C/zh not_active Expired - Fee Related
- 2004-09-30 BR BRPI0414972-6A patent/BRPI0414972A/pt not_active IP Right Cessation
- 2004-09-30 AT AT04787263T patent/ATE399169T1/de not_active IP Right Cessation
- 2004-09-30 CA CA002540083A patent/CA2540083A1/en not_active Abandoned
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- 2004-09-30 EA EA200600608A patent/EA010261B1/ru not_active IP Right Cessation
- 2004-09-30 EP EP04787263A patent/EP1675854B1/en not_active Expired - Lifetime
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- 2004-09-30 DE DE602004014630T patent/DE602004014630D1/de not_active Expired - Lifetime
- 2004-09-30 KR KR1020067005873A patent/KR20060092220A/ko not_active Withdrawn
- 2004-09-30 ES ES04787263T patent/ES2309567T3/es not_active Expired - Lifetime
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2006
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2008
- 2008-09-26 US US12/232,973 patent/US20090036482A1/en not_active Abandoned
Also Published As
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|---|---|
| CN100415745C (zh) | 2008-09-03 |
| BRPI0414972A (pt) | 2006-11-07 |
| ZA200601642B (en) | 2007-05-30 |
| EA010261B1 (ru) | 2008-06-30 |
| MXPA06003349A (es) | 2006-06-08 |
| EP1675854B1 (en) | 2008-06-25 |
| JP2007507467A (ja) | 2007-03-29 |
| IL173895A0 (en) | 2006-07-05 |
| ATE399169T1 (de) | 2008-07-15 |
| EP1675854A1 (en) | 2006-07-05 |
| US7468377B2 (en) | 2008-12-23 |
| NO20061344L (no) | 2006-03-24 |
| NZ546437A (en) | 2009-09-25 |
| EA200600608A1 (ru) | 2006-10-27 |
| US20070043073A1 (en) | 2007-02-22 |
| RS20060196A (sr) | 2008-08-07 |
| CN1856491A (zh) | 2006-11-01 |
| AU2004276015A1 (en) | 2005-04-07 |
| WO2005030771A1 (en) | 2005-04-07 |
| US20090036482A1 (en) | 2009-02-05 |
| CA2540083A1 (en) | 2005-04-07 |
| ES2309567T3 (es) | 2008-12-16 |
| HK1096548A1 (zh) | 2007-06-01 |
| DE602004014630D1 (de) | 2008-08-07 |
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