KR20060006141A - Injection equipment for a plurality of substances - Google Patents

Abstract

The present invention relates to an injection device capable of administering a plurality of drugs, and is equipped with a plurality of drugs in a drug storage container that can be coupled to or connected to the cylinder portion of the injection device so that the needle can be continuously replaced without changing the needle or without removing the needle from the human body. The present invention relates to an injection device capable of administering a large number of drugs to different desired sites. Unlike conventional injection devices, a precise amount of a desired drug can be precisely injected at a desired location. This is a very useful effect.

Injection Device, Drug Storage Container, Multi-Dose, Auto Injection Device

Description

Injection device for administering a plurality of drugs

1 (a) and 1 (b) show an embodiment of an injection apparatus according to the present invention ((a): longitudinal section, (b): perspective view).

2 (a) and 2 (b) show one-way valves that can be used in the injection device according to the invention ((a): open, (b): closed)

3 (a)-(c) show yet another embodiment of an injection device according to the invention ((a): longitudinal section, (b) a perspective view and FIG. 3 (c) aa 'section) to be.

4 shows a hinged diaphragm structure that can be used in the injection device according to the present invention.

 Figure 5 (a) is a separate shape of the removable wing that can be used in the injection device of the present invention, Figure 5 (b) shows a side view when coupled to the syringe.

6 (a) and 6 (b) show a side view of the automatic injection device according to the present invention ((a): perspective view, (b): longitudinal cross section).

The present invention relates to an injection device capable of administering a plurality of drugs, and is equipped with a plurality of drugs in a drug storage container that can be coupled to or connected to the cylinder portion of the injection device to continuously replace the needle without removing the needle from the human body. An injection device capable of administering a plurality of drugs to different layers or sites of the human body.

In traditional medicine, drugs are given orally or intravenously. Complementary therapies such as nutritional supplements are usually administered orally. Also, syringes can be used only intravenously or subcutaneously, and the drug is administered directly to the topical site. Not suitable for However, systemic administration to patients with problems in the body causes unwanted systemic side effects and disadvantages in terms of drug efficacy. In the case of oral administration, many patients are unable to administer oral due to drug side effects, gastrointestinal disorders, and surgery.

For example, according to traditional treatment techniques, drugs are given systemically to only a small portion of the neuroma of the foot, and these drugs act on the blood vessels of the brain, causing side effects, or passing through the liver or kidneys. Is difficult. Therefore, a therapeutic method that can be selectively administered directly to the local epidermis, dermis, subcutaneous, blood vessels, nerves, sacs, tendons, muscles, fascia, ligaments, periosteum, synovial membrane, joints, cartilage, etc., without going through the liver or kidney is desirable. Currently, some of these treatments are possible. In addition, the development of optical diagnostic equipment, which is essential for such treatment methods, is actively progressing in developed countries.

In addition, in order to administer the drug using a conventional syringe, the patient's lesion (for example, muscle) is promoted, and then the lesion (for example, a tenderness point) is identified, the drug is injected, and another drug is injected again. In order to move the pre-promoted lesions to find the lesions, the time and effort are doubled.In addition, the patient has to change the syringe several times each time the drug combination, type, and treatment method is changed, resulting in increased discomfort. The entire treatment time for the patient is lengthened. In addition, since the injection point is confirmed by the sense of the hand of the doctor (therapist), especially when injecting various drugs into different sites and tissues, the accuracy is lowered, and a lot of skill is required for the master's mastery. This is especially true for anesthetic injections.

On the other hand, the ultrasound device is inexpensive and non-invasive to identify each layer of the skin, and recently, due to the development of molecular imaging medicine, optical devices that can identify the nerves very precisely are being developed one after another.

Therefore, in the future, it is possible to diagnose the disease by imaging lesions related to metabolism at the cellular level using precise optics and to inject drugs locally to the identified lesions and immediately confirm the treatment results.

In order to utilize the treatment method as described above, the development of an injection device capable of administering a plurality of drugs without replacing the needle while replacing a suitable drug for each layer of the skin while checking the injection needle with an optical device is urgently required.

 BACKGROUND OF THE INVENTION A syringe which is conventionally used for storing a plurality of drugs in a separate container and then injecting is disclosed in Korean Patent No. 10-0340287. However, the syringe is a disposable syringe used by a soldier who has been attacked by a chemical weapon during a battle to inject the soldier himself to detoxify the poisoning of the chemical weapon on the spot immediately. The purpose of the primary fraud is to inject a mixture of two drugs just prior to injection, not to inject each drug separately. Many manual and automatic syringes are known that can be injected after mixing, including a number of separate pharmaceutical ingredients, but no injectors capable of injecting multiple drugs, respectively, have been studied.

However, as described above, the development of new diagnostics and treatments in the future is urgently required to develop a new type of syringe that can be continuously injected while distinguishing specific tissues of the human body by separately or mixing a plurality of drugs.

In addition, when administered to nerves or specialized tissues it is necessary to precisely adjust the dosage, for which it can be operated manually or by mechanical means such as spring tension or gas pressure or electronically or automatically by other data processing means. What is needed is an injection device that can be used.

The present invention is to solve the above problems, an object of the present invention can be equipped with a plurality of drugs and without mixing the drug without replacing the drug in the human body without replacing the needle or each tissue of the human body It is to provide a syringe that can be continuously injected into each star. Such a syringe is highly desirable for a novel therapeutic method capable of administering an appropriate drug to a topical site while identifying a lesion in vivo with the development of an optical instrument.

It is still another object of the present invention to provide a means for controlling the needle insertion speed, the insertion depth, the amount of drug injection, and the like, and a means for programming them, so that the type, insertion depth and drug of the drug as programmed according to the condition of the patient. It is to provide an automatic syringe that can be injected by selecting the amount of.

Various objects of the present invention will become more apparent according to the following detailed description and the appended claims.

According to the principles of the present invention, the object is a needle portion, a cylinder portion connected to the needle portion, a passage portion formed in at least one position located in front of the maximum forward position of the piston of the cylinder portion or the surface of the cylinder portion, the cylinder portion It is made by an injection device comprising a piston portion inserted into, a drug reservoir that can be coupled to the passageway, and a chamber formed to receive the drug reservoir.

Preferably the connecting portion of the needle and the cylinder portion is provided with a means for discharging only the drug, for example a one-way valve or a hinged diaphragm and the passage portion is one-way so that the drug can be discharged only toward the cylinder portion. Valves or hinged diaphragms may be provided. If necessary, an additional opening and closing valve may be provided between the passage part and the drug storage container so as to be opened and closed. One-way valves or on-off valves used in the present invention can use those known to those skilled in the art.

More preferably, the syringe of the present invention is further provided with a removable wing that is mounted to surround the outside of the needle portion of the rubber material. When the removable wing is mounted, the syringe is less likely to be shaken during the injection of the drug, so that the drug can be injected more stably.

The syringe of the present invention is to inject each drug into the cylinder through the passageway by using a piston while changing the drug by rotating the drug storage container or by opening and closing the opening and closing valve provided between the passage portion and the drug reservoir. By dispensing the drugs into the human body by mixing each drug or sequentially using the piston, each time a drug is changed, a plurality of drugs can be injected into the human body without changing the needle or removing a needle. There is an advantage.

Preferably, the connecting part of the needle part and the cylinder part is further formed with a driving part, the driving part side end of the needle part is formed with a locking jaw and the driving part includes a cylindrical drive shaft having a female screw for receiving a locking jaw formed at the needle part. can do. The needle part may be detachably coupled to the cylinder part to replace the needle. Rotation of the drive shaft changes the insertion depth of the needle mounted in the needle portion.

In the autoinjector of the present invention, one or more drive mechanisms operated by a power source in the region of the rear end of the cylinder portion are operated by a motor under the control of the electronic control unit. The motor is capable of reverse rotation. The one or more drive mechanisms drive the piston shaft to move in a predetermined position. It also drives translational movement in the longitudinal direction of the cylinder portion of the chamber and rotational movement around the cylinder portion. In addition, the connecting portion of the needle portion and the cylinder portion is formed with a driving portion, the end of the driving portion of the needle portion is formed with a locking jaw and the driving portion has a cylindrical drive shaft formed with a female thread for receiving the locking jaw formed in the needle portion, the at least one One of the drive mechanisms drives the drive shaft.

The injection device is provided with an electronic control unit, which is connected to the at least one drive mechanism and the user interface. The user interface includes a display panel and user operation buttons.

The syringe may include a port for communication between the electronic control unit and an external device such as a personal computer.

The display panel is generally an LCD display and provides Arabic numerals and graphical information regarding the operation of the syringe. Preferably, the display panel displays the dosage, order of drug administration, drug injection rate, and the like.

User control buttons have a number of functions. The user can select the required dose and determine the injection speed and insertion depth of the needle. In addition, the user can determine the order of the drugs to be injected and whether to be administered or mixed, respectively, to enter or select a program or directly control the program.

Hereinafter, the configuration and operation method of the syringe of the present invention will be described in detail with reference to the drawings and embodiments, but the spirit of the present invention is not limited thereto.

Example  One

1 (a) and 1 (b) show a syringe made in accordance with the present invention. (A) is sectional drawing of a longitudinal direction, and FIG. 1 (b) is a perspective view.

The passage part 6 provided in the cylinder part 2 of this injection apparatus is provided with the valve 62 which can be opened and closed. The chamber 4 equipped with the drug storage container 5 is fixed to the outside of the cylinder portion 2, and the guide blade 7 is formed toward the inside of the chamber 4 at the portion where the passage portion 6 and the chamber 4 are connected, and in the center of the guide blade The hollow needle 61 is formed to be connected to the passage 6. When the prepackaged drug storage container 5 having a papillary protrusion is mounted, the outer circumference of the protrusion is combined with the guide wing, and the entire outer circumference of the drug storage container 5 is combined with the chamber 4. The chamber 4 is transparent to identify the amount or type of drug in the drug reservoir 5 mounted in the chamber 4.

The syringe of FIG. 1 operates as follows.

When the prepackaged drug storage containers 5 having protrusions are installed in the chamber, the hollow needle connected to the passage part ruptures the membrane of the drug storage container 5 and engages with the drug storage container. If only the opening and closing valve of the passageway connected to the desired drug storage container is opened and the piston is retracted by applying force to the shaft head 31, the drug in the desired drug storage container is injected into the cylinder 21, the drug is injected into the cylinder 21, and then When the piston is advanced by reversing the applied force, drugs are injected into the human body. At this time, the one-way valve 11 provided in the connecting portion between the needle portion and the cylinder portion in the process of injecting the drug into the cylinder 21, the blood in the body does not flow into the cylinder, the drug in the process of injecting the drug inside the cylinder into the human body Shut off valve 62 in the passageway connected to the reservoir to prevent the drug from entering the cylinder. In the process of injecting the drug into the cylinder 21, the valve 62 of the passageway connected to the other drug storage container is opened and the above procedure is repeated to mix the drugs or to inject the drugs into the human body and then to replace the drugs to be injected into the human body. Can be.

Figure 2 shows a one-way valve 11 that can be used in the above injection device. Figure 2 (a) shows that the drug inside the cylinder is injected into the human body when the piston is advanced, Figure 2 (b) is the connection between the needle portion and the cylinder portion is closed by the one-way valve when the piston is reversed It is shown.

Example  2

In addition to the passage portion provided in the cylinder portion of the injection device in the same syringe of the first embodiment is provided with a one-way valve to allow the drug of the drug storage container to only flow into the cylinder. In this case, even when the opening / closing valve of the passage is opened when the drug is injected into the human body, the drug inside the cylinder can be prevented from flowing back into the drug storage container.

Example  3

3 shows another embodiment of an injection device according to the invention. Fig. 3 (a) is a longitudinal sectional view, Fig. 3 (b) is a perspective view and Fig. 3 (c) is a-a 'cross sectional view.

Guide vanes 7 are provided at the end of the passage section 6 provided in the cylinder section 2 of the injection device, and a hollow needle 61 is mounted at the center of the guide vanes and a chamber 4 equipped with a drug storage container is formed in the longitudinal direction outside the cylinder. By having a guide protrusion 22 and a corresponding guide groove 42, it is possible to rotate intermittently around the cylinder and to move back and forth of the cylinder part 2 along the guide protrusion 22. At this time, the guide groove may be provided outside the cylinder and the guide protrusion may be provided in the chamber 4. The chamber 4 is provided with a locking jaw 221 in the guide groove or the guide protrusion so that the chamber 4 can move back and forth only at a predetermined position.

The material of the drug storage container 5 mounted on the chamber 4 is a watertight material that can be ruptured with a needle and resealed when the needle is removed. The chamber is transparent and can identify the amount or type of drug in the drug storage container mounted in the chamber.

The syringe works as follows.

Advance the chamber 4 to the hollow needle 61 so that the desired position of the drug reservoir extends with the hollow needle 61 installed at the end of the passage 6, and the hollow needle penetrates the membrane of the drug reservoir. After applying the force to the shaft head 31 to reverse the piston, the drug in the desired drug reservoir is injected into the cylinder and the desired amount is injected into the cylinder 21. Then, the force applied to the shaft head 31 is reversed to advance the piston. Drugs are injected into At this time, in the process of injecting the drug into the cylinder 21, the blood in the body is not injected into the cylinder by the one-way valve 11 provided at the connection portion between the needle 1 and the cylinder 2, and the drug in the cylinder 21 is injected into the human body. In the passage 6, the drug in the cylinder 21 is not introduced into the drug storage container 5 by the one-way valve 63 in the passage 6 (see the enlarged one-way valve 63 in Fig. 3 (a)). When changing or mixing the drug, reverse the chamber 4, rotate the chamber 4 so that the other drug reservoir is in the position extending from the hollow needle 61, and advance the chamber again so that the hollow needle penetrates the membrane of the drug reservoir. Repeat the above process. There is a groove on the outside of the chamber 4.

Example  4

The connecting portion of the needle portion and the cylinder portion of another injection device according to the present invention may be provided with a hinged diaphragm 12 as a means for allowing only drug discharge. The diaphragm 12 is formed in the connecting portion, one end of the diaphragm 12 is hinged to the connecting portion, and a protrusion 13 is formed on the inner surface of the connecting portion corresponding to the other end so that the drug in the cylinder can be discharged only to the needle portion. do. In addition, the same hinge-bonded diaphragm may be provided in the passage portion formed on the cylinder portion to be combined with the drug storage container so that the drug of the drug storage container can only be introduced into the cylinder. 4 shows the structure of such a hinge joint.

Example  5

Figure 5 shows a separate shape (a) of a removable wing 10 that can be used in the injection device of the present invention, a side view (b) when coupled to a syringe. When injected into the back of the hand, arms, legs and back, the removable wing 10 can be combined to inject the drug more stably, and when injected into narrow areas such as between the fingers can be removed and used.

Example  6

6 is a perspective view of an automatic injection device according to the present invention.

The automatic scanning device includes a main housing 11 in which an end cap or cover 111 is detachably fixed. When the injection device is not used, the end cap or cover 111 can be closed to prevent contamination of the needle portion and to prevent accidental puncture of a needle other than the patient.

In the region of the rear end of the cylinder portion 2 inside the main housing 11, a drive mechanism is provided which operates by the power source and acts on the piston shaft 31. The power source may be provided from a battery or an external power source. The drive mechanism is operated by a motor under the control of an electronic control unit. The motor must be capable of reverse rotation to allow the piston to move between positions. The motor may drive the piston through the gear train so as to move the piston relative to the third rotor by rotation of the third rotor. Further, a drive mechanism (not shown) is provided for driving the forward and backward movements of the chamber and the intermittent rotational movement in the backward position of the chamber. The connecting part of the needle part and the cylinder part is formed with a driving part, the end of the driving part of the needle part is formed with a locking jaw, and the driving part has a cylindrical drive shaft formed with a female thread for receiving a locking step formed at the needle part. A driving mechanism (not shown) for driving is provided.

The main housing 11 of the injection device is provided with a handle, which is easy to grip and has an electronic control unit therein. The electronic control unit includes a piston drive mechanism, a drive mechanism of a chamber, and a drive mechanism of a cylindrical drive shaft of a connecting portion. And user interface. The user interface includes a display panel 112 and user operation buttons 113 and 114.

The display panel 112 is an LCD display and provides Arabic numeral and graphic information related to the operation of the scanning apparatus. Preferably, the display panel displays the dosage, order of drug administration, drug injection rate, and the like.

User control buttons 113 on the back of the injection device can control the insertion depth of the piston, the rotation and translation of the chamber, and the user control button 114 to input the program at the bottom of the display panel. The program can be input or selected by determining the type and order of the injected drugs, the dose, the injection speed, and mixing.

The injection device of the present invention can be equipped with a plurality of drugs in a drug storage container to continuously administer a plurality of drugs to different tissues without a needle exchange or without removing the needle from the human body. In addition, unlike the conventional injection device, the precise amount of the desired drug can be injected precisely at the desired position, which is a very useful effect in the treatment method by precise layered topical injection therapy, and is an invention having a very excellent effect in the medical industry.

Claims (9)

In the injection device, Needle part; A cylinder portion connected to the needle portion; A piston part inserted into the cylinder part; A passage portion formed on at least one of the front surface of the cylinder portion or the surface of the cylinder portion located before the maximum forward position of the piston; Two or more drug reservoirs that may be coupled to the passageway; And a chamber configured to receive the drug reservoir. According to claim 1, wherein the surface of the cylinder portion is circular, a guide protrusion or guide groove formed in the longitudinal direction thereon, the chamber is provided with a guide groove or guide protrusion corresponding to the guide protrusion or guide groove, And a chamber moves intermittently around the cylinder and moves along the guide groove or guide protrusion on the cylinder portion. The injection device according to claim 1, wherein the needle part and the cylinder part are provided with a one-way valve installed only to discharge the drug. The injection device according to claim 1, wherein the passage portion further includes at least one of a one-way valve and an on-off valve installed so that the drug can only flow into the cylinder portion. 2. A membrane according to claim 1, wherein a diaphragm is formed in at least one of the connecting portion of the needle portion and the cylinder portion, one end of the diaphragm is hinged to the connecting portion, and a protrusion is formed on the inner surface of the connecting portion corresponding to the other end. Injector, characterized in that formed 2. A membrane according to claim 1, wherein at least one of the passage portions is formed with a diaphragm, one end of the diaphragm is hinged to the passage portion, and a protrusion is formed on an inner surface of the passage portion corresponding to the other end thereof. An injection device comprising an opening / closing valve in a passage portion, or both a diaphragm and an opening / closing valve hinged. The method of claim 1, wherein the connecting portion of the needle portion and the cylinder portion is a drive portion is further formed, the driving end portion of the needle portion is formed with a locking jaw and the drive portion is formed with a female screw for receiving the locking jaw formed in the needle portion An injection device comprising a cylindrical drive shaft. 3. An injection apparatus according to claim 2, wherein said chamber or piston is connected to a drive mechanism, said drive mechanism controlling rotational and translational movement of said chamber or piston part. 7. An injection apparatus according to claim 6, further comprising a drive mechanism for driving said cylindrical drive shaft, said drive mechanism controlling the insertion depth.

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