KR20050109934A - 관능기의 단백질로의 공유 테더링 - Google Patents
관능기의 단백질로의 공유 테더링 Download PDFInfo
- Publication number
- KR20050109934A KR20050109934A KR1020057014186A KR20057014186A KR20050109934A KR 20050109934 A KR20050109934 A KR 20050109934A KR 1020057014186 A KR1020057014186 A KR 1020057014186A KR 20057014186 A KR20057014186 A KR 20057014186A KR 20050109934 A KR20050109934 A KR 20050109934A
- Authority
- KR
- South Korea
- Prior art keywords
- substrate
- mutant
- protein
- hydrolase
- amino acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y308/00—Hydrolases acting on halide bonds (3.8)
- C12Y308/01—Hydrolases acting on halide bonds (3.8) in C-halide substances (3.8.1)
- C12Y308/01005—Haloalkane dehalogenase (3.8.1.5)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44409403P | 2003-01-31 | 2003-01-31 | |
US60/444,094 | 2003-01-31 | ||
US47465903P | 2003-05-30 | 2003-05-30 | |
US60/474,659 | 2003-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20050109934A true KR20050109934A (ko) | 2005-11-22 |
Family
ID=32871922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020057014186A KR20050109934A (ko) | 2003-01-31 | 2004-01-30 | 관능기의 단백질로의 공유 테더링 |
Country Status (7)
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004072232A2 (en) | 2003-01-31 | 2004-08-26 | Promega Corporation | Covalent tethering of functional groups to proteins |
US7429472B2 (en) * | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
EP3179252B1 (en) * | 2004-07-30 | 2018-11-14 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
US20070087400A1 (en) * | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
EP1821094A1 (en) * | 2004-12-07 | 2007-08-22 | Effector Cell Institute, Inc. | Cell measuring method |
EP1899367A4 (en) * | 2005-06-10 | 2009-06-24 | Univ Singapore | MUTANT ALLERGENS |
FR2890446B1 (fr) | 2005-09-05 | 2008-04-18 | Cis Bio Internat Sa | Methode de detection d'interaction intracellulaire entre bio-molecules |
EP1945262A2 (en) * | 2005-10-20 | 2008-07-23 | The Scripps Research Institute | Fc labeling for immunostaining and immunotargeting |
WO2007081716A2 (en) | 2006-01-04 | 2007-07-19 | Stanford University | Self-illuminating quantum dot systems and methods of use thereof |
US20070224620A1 (en) * | 2006-02-08 | 2007-09-27 | Promega Corporation | Compositions and methods for capturing and analyzing cross-linked biomolecules |
US7449299B2 (en) * | 2006-03-10 | 2008-11-11 | David Bauer | Quantum dot nanoparticle-based universal neurotoxin biosensor |
CA2653256C (en) * | 2006-05-25 | 2018-08-28 | Institute For Advanced Study | Methods for identifying sequence motifs, and applications thereof |
DE102006045607A1 (de) * | 2006-09-25 | 2008-03-27 | Leica Microsystems Cms Gmbh | Verfahren zur räumlich hochauflösenden Untersuchung von einer mit einer fluoreszierenden Substanz markierten Struktur einer Probe |
WO2008054821A2 (en) * | 2006-10-30 | 2008-05-08 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and functional expression |
FR2934684B1 (fr) | 2008-07-31 | 2012-11-16 | Cis Bio Int | Methode de detection de l'internalisation de proteines membranaires. |
CA2759885A1 (fr) | 2009-04-30 | 2010-11-04 | Etienne Doumazane | Procede de detection de composes modulateurs de dimeres de proteines membranaires a domaine vft |
FR2949156B1 (fr) | 2009-08-13 | 2016-04-15 | Cis-Bio Int | Methode de determination de la liaison d'un compose donne a un recepteur membranaire |
US8476014B2 (en) * | 2010-02-19 | 2013-07-02 | Los Alamos National Security, Llc | Probe and method for DNA detection |
BR112013010484B1 (pt) | 2010-11-02 | 2019-09-03 | Promega Corp | derivados de coelenterazina e métodos de utilizar os mesmos |
KR101939553B1 (ko) | 2010-11-02 | 2019-01-17 | 프로메가 코포레이션 | 신규 코엘렌테라진 기질 및 사용 방법 |
EP2649099A4 (en) * | 2010-12-07 | 2016-10-19 | Univ Yale | HYDROPHOBIC MARKING OF SMALL MOLECULES OF FUSION PROTEINS AND INDUCED DEGRADATION THEREOF |
FR2980271B1 (fr) | 2011-09-16 | 2013-10-11 | Cisbio Bioassays | Procede de determination de la glycosylation d'un anticorps |
WO2013078244A1 (en) | 2011-11-21 | 2013-05-30 | Promega Corporation | Carboxy x rhodamine analogs |
JP6231503B2 (ja) | 2012-03-09 | 2017-11-15 | プロメガ コーポレイションPromega Corporation | pHセンサー |
US9040239B2 (en) | 2012-03-15 | 2015-05-26 | New England Biolabs, Inc. | Composition and methods of oxygenation of nucleic acids containing 5-methylpyrimidine |
FR2988174B1 (fr) | 2012-03-19 | 2014-04-25 | Cisbio Bioassays | Procede de determination de la capacite d'un anticorps a maintenir des cellules a proximite l'une de l'autre |
US9585975B2 (en) * | 2012-04-27 | 2017-03-07 | Northwestern University | MRI contrast agents |
KR101923632B1 (ko) | 2012-07-31 | 2018-12-03 | 이스케이프 테라퓨틱스, 인코퍼레이티드 | Hla g-변형된 세포 및 방법 |
WO2014035712A1 (en) * | 2012-08-28 | 2014-03-06 | Pierce Biotechnology, Inc. | Benzopyrylium compounds |
US9551705B2 (en) | 2012-12-12 | 2017-01-24 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
US11072812B2 (en) | 2013-03-15 | 2021-07-27 | Promega Corporation | Substrates for covalent tethering of proteins to functional groups or solid surfaces |
US9567632B2 (en) | 2013-03-19 | 2017-02-14 | New England Biolabs, Inc. | Enrichment of target sequences |
EP3099691B1 (en) | 2014-01-29 | 2019-11-20 | Promega Corporation | Pro-substrates for live cell applications |
EP3099683B1 (en) | 2014-01-29 | 2020-08-05 | Promega Corporation | Quinone-masked probes as labeling reagents for cell uptake measurements |
CN106536571B (zh) * | 2014-04-30 | 2019-12-17 | 阿朗新科新加坡私人有限公司 | 用于生产丁基橡胶的稀释剂 |
JP2017537657A (ja) | 2014-12-11 | 2017-12-21 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | 標的配列の濃縮 |
WO2016196956A1 (en) | 2015-06-05 | 2016-12-08 | Promega Corporation | Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements |
EP3430015A1 (en) | 2016-03-16 | 2019-01-23 | Oryzon Genomics, S.A. | Methods to determine kdm1a target engagement and chemoprobes useful therefor |
CA3017214A1 (en) * | 2016-03-16 | 2017-09-21 | Purdue Research Foundation | Carbonic anhydrase ix targeting agents and methods |
CN113444094B (zh) | 2016-07-20 | 2023-12-22 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
US11327072B2 (en) | 2017-02-09 | 2022-05-10 | Promega Corporation | Analyte detection immunoassay |
WO2018234557A1 (en) * | 2017-06-23 | 2018-12-27 | Nanotemper Technologies Gmbh | METHODS OF MEASURING INTER- AND / OR INTRA-MOLECULAR INTERACTIONS |
CN109574880B (zh) | 2017-09-29 | 2022-06-17 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
CN110498799B (zh) | 2018-05-18 | 2022-07-05 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
EP3803401A4 (en) | 2018-05-30 | 2022-02-23 | Promega Corporation | BROAD-SPECTRUM KINASE BINDERS |
US20200200765A1 (en) | 2018-12-04 | 2020-06-25 | Promega Corporation | Broad spectrum gpcr binding agents |
WO2020191339A1 (en) | 2019-03-20 | 2020-09-24 | Promega Corporation | Photoaffinity probes |
EP3956352A1 (en) | 2019-04-16 | 2022-02-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften E. V. | Circularly permutated haloalkane transferase fusion molecules |
EP3816180A1 (en) | 2019-10-31 | 2021-05-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Circularly permutated haloalkane transferase fusion molecules |
CN110646417B (zh) * | 2019-10-24 | 2021-10-15 | 福建医科大学 | 以纳米金为显色探针的磷酸吡哆醛快速测定方法 |
EP4073512A1 (en) | 2019-12-10 | 2022-10-19 | Promega Corporation | Compositions and methods for bioluminescent detection using multifunctional probes |
EP4118233A1 (en) | 2020-03-12 | 2023-01-18 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
US20210363565A1 (en) | 2020-05-22 | 2021-11-25 | Promega Corporation | Enhancement of kinase target engagement |
EP4110945A2 (en) | 2020-08-21 | 2023-01-04 | New England Biolabs, Inc. | A rapid diagnostic test for lamp |
JP2023540934A (ja) | 2020-08-28 | 2023-09-27 | プロメガ コーポレイション | Rasタンパク質のターゲットエンゲージメントアッセイ |
AU2021423664A1 (en) | 2021-01-28 | 2023-09-07 | Genequantum Healthcare (Suzhou) Co., Ltd. | Ligase fusion proteins and applications thereof |
US20230203562A1 (en) | 2021-12-28 | 2023-06-29 | Encodia, Inc. | High-throughput serotyping and antibody profiling assays |
WO2023215514A2 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Bioluminescence-triggered photocatalytic labeling |
WO2023215452A2 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Split modified dehalogenase variants |
US20240060059A1 (en) | 2022-05-04 | 2024-02-22 | Promega Corporation | Circularly permuted dehalogenase variants |
WO2023215505A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Modified dehalogenase with extended surface loop regions |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3131122A (en) | 1961-04-14 | 1964-04-28 | Boehringer Sohn Ingelheim | Method of producing analgesia with n-substituted-4-phenyl-4-carbalkoxypiperidines |
DE1229532B (de) | 1961-04-14 | 1966-12-01 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung neuer Piperidinderivate |
US4574079A (en) | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
US4612302A (en) | 1983-11-14 | 1986-09-16 | Brigham And Women's Hospital | Clinical use of somatostatin analogues |
US4684620A (en) | 1984-09-04 | 1987-08-04 | Gibson-Stephens Neuropharmaceuticals, Inc. | Cyclic polypeptides having mu-receptor specificity |
US4812409A (en) | 1986-01-31 | 1989-03-14 | Eastman Kodak Company | Hydrolyzable fluorescent substrates and analytical determinations using same |
DE3614647A1 (de) * | 1986-04-30 | 1987-11-05 | Euratom | 7-phenylessigsaeure-4-alkyl-coumarinylamide, verfahren zu ihrer herstellung sowie ihre verwendung in verfahren zur fluorometrischen bestimmung der aktivitaet von hydrolasen, insbesondere von penicillin-g-acylase |
US4853371A (en) | 1986-06-17 | 1989-08-01 | The Administrators Of The Tulane Educational Fund | Therapeutic somatostatin analogs |
EP0258898B1 (en) * | 1986-09-04 | 1992-04-22 | Idemitsu Kosan Company Limited | Liquid-crystalline polymer |
US4810636A (en) | 1986-12-09 | 1989-03-07 | Miles Inc. | Chromogenic acridinone enzyme substrates |
CS259396B1 (en) * | 1987-05-06 | 1988-10-14 | Jozef Luston | 1,2,2,6,6-pentamethyl-4-(delta-bromalkoxy) piperidines and method of their preparation |
SE8900130D0 (sv) | 1989-01-16 | 1989-01-16 | Klaus Mosback | Konceptet att med hjaelp av molekylavtrycksmetoden framstaella konstgjorda antikroppar genom imprinting av t ex antigener samt att framstaella konstgjorda entzymer genom imprintning med transition state analoger |
US5071469A (en) | 1989-04-21 | 1991-12-10 | E. I. Du Pont De Nemours And Company | Herbicidal benzylsulfonamides |
US5498694A (en) | 1989-05-25 | 1996-03-12 | La Jolla Cancer Research Foundation | Peptides of the cytoplasmic domain of integrin |
US5128247A (en) | 1989-08-14 | 1992-07-07 | Board Of Regents, The University Of Texas System | Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources |
US5099020A (en) | 1989-11-27 | 1992-03-24 | Abbott Laboratories | Barbiturate assay compositions and methods |
DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech Inc | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
WO1993004192A1 (en) * | 1991-08-23 | 1993-03-04 | Molecular Probes, Inc. | Use of haloalkyl derivatives of reporter molecules to analyze metabolic activity in cells |
FR2700855B1 (fr) | 1993-01-28 | 1995-03-03 | Commissariat Energie Atomique | Dosage immunométrique d'un antigène ou d'un haptène. |
US5372944A (en) | 1993-10-14 | 1994-12-13 | The Dow Chemical Company | Method for conversion of halogenated hydrocarbons to halohydrins |
US5523209A (en) | 1994-03-14 | 1996-06-04 | The Scripps Research Institute | Methods for identifying inhibitors of integrin activation |
US5503977A (en) | 1994-04-22 | 1996-04-02 | California Institute Of Technology | Split ubiquitin protein sensor |
JP3583489B2 (ja) | 1994-12-22 | 2004-11-04 | 日清紡績株式会社 | カルボジイミド誘導体 |
CH689633A5 (de) | 1995-01-10 | 1999-07-30 | Von Roll Umwelttechnik Ag | Verfahren zur Kuehlung und Reinigung von Rauchgasen. |
WO1997014740A1 (en) * | 1995-10-19 | 1997-04-24 | Receptagen Corporation | Discrete-length polyethylene glycols |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
US5786428A (en) | 1996-03-27 | 1998-07-28 | California Institute Of Technology | Adsorbents for amino acid and peptide separation |
US6255461B1 (en) | 1996-04-05 | 2001-07-03 | Klaus Mosbach | Artificial antibodies to corticosteroids prepared by molecular imprinting |
US6162931A (en) | 1996-04-12 | 2000-12-19 | Molecular Probes, Inc. | Fluorinated xanthene derivatives |
US5945526A (en) * | 1996-05-03 | 1999-08-31 | Perkin-Elmer Corporation | Energy transfer dyes with enhanced fluorescence |
US6416733B1 (en) * | 1996-10-07 | 2002-07-09 | Bristol-Myers Squibb Pharma Company | Radiopharmaceuticals for imaging infection and inflammation |
US5853993A (en) * | 1996-10-21 | 1998-12-29 | Hewlett-Packard Company | Signal enhancement method and kit |
US5932421A (en) | 1996-12-06 | 1999-08-03 | The Scripps Research Institute | Methods and cell lines for identification of regulators of integrin activation |
IL131209A0 (en) | 1997-02-13 | 2001-01-28 | Dow Chemical Co | Recombinant haloaliphatic dehalogenases |
US6333154B1 (en) | 1997-12-04 | 2001-12-25 | Institut Pasteur | Bacterial multi-hybrid system and applications thereof |
WO2001046476A1 (en) * | 1999-12-23 | 2001-06-28 | Maxygen, Inc. | Alteration of hydrolase genes and screening of the resulting libraries for the ability to catalyze specific reactions |
FR2804116B1 (fr) | 2000-01-20 | 2002-08-23 | Centre Nat Rech Scient | Composes organosilicies, leur procede de preparation et leurs utilisations |
AU2001238485A1 (en) * | 2000-02-18 | 2001-08-27 | The Immune Response Corporation | Methods and compositions for gene delivery |
AU2001227280A1 (en) | 2000-04-10 | 2001-10-23 | The Scripps Research Institute | Proteomic analysis using activity-based probe libraries |
AU9650201A (en) | 2000-10-02 | 2002-04-15 | Molecular Probes Inc | Reagents for labeling biomolecules having aldehyde or ketone moieties |
JP2005502310A (ja) | 2000-12-01 | 2005-01-27 | ディヴァーサ コーポレイション | ハイドロラーゼ酵素および速度論的分割における用途 |
MXPA03004840A (es) | 2000-12-01 | 2008-10-08 | Verenium Corp | Enzimas que tienen actividad de deshalogenasa y metodos. |
JP4880188B2 (ja) | 2001-01-23 | 2012-02-22 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 核酸プログラム型タンパク質アレイ |
NZ528594A (en) | 2001-04-10 | 2005-07-29 | Ecole Polytech | Methods using O6-alkylguanine-DNA alkyltransferases |
GB0111987D0 (en) * | 2001-05-16 | 2001-07-04 | Univ Sheffield | Method |
US7176242B2 (en) | 2001-11-08 | 2007-02-13 | Elan Pharmaceuticals, Inc. | N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives |
EP1540008A4 (en) | 2002-07-19 | 2006-04-12 | Diversa Corp | FLUORESCENT PROTEINS, NUCLEIC ACIDS ENCODING THEM, AND METHODS OF MAKING AND USING SAME |
AU2003291151A1 (en) | 2002-11-22 | 2004-06-18 | Carnegie Mellon University | Compositions and methods for the reversible capture of biomolecules |
WO2004072232A2 (en) | 2003-01-31 | 2004-08-26 | Promega Corporation | Covalent tethering of functional groups to proteins |
US7429472B2 (en) | 2003-01-31 | 2008-09-30 | Promega Corporation | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule |
US7195882B2 (en) * | 2003-06-03 | 2007-03-27 | Roche Diagnostics Operations, Inc. | Monoclonal antibodies specific for buprenorphine and metabolites thereof |
US20050095651A1 (en) | 2003-08-12 | 2005-05-05 | The Regents Of The University Of California | Photoswitchable method for the ordered attachment of proteins to surfaces |
US7425436B2 (en) | 2004-07-30 | 2008-09-16 | Promega Corporation | Covalent tethering of functional groups to proteins and substrates therefor |
US20070087400A1 (en) | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
US20070224620A1 (en) | 2006-02-08 | 2007-09-27 | Promega Corporation | Compositions and methods for capturing and analyzing cross-linked biomolecules |
WO2008054821A2 (en) | 2006-10-30 | 2008-05-08 | Promega Corporation | Mutant hydrolase proteins with enhanced kinetics and functional expression |
-
2004
- 2004-01-30 WO PCT/US2004/002607 patent/WO2004072232A2/en active Search and Examination
- 2004-01-30 JP JP2006503174A patent/JP4748685B2/ja not_active Expired - Lifetime
- 2004-01-30 EP EP11005045.7A patent/EP2455458B1/en not_active Expired - Lifetime
- 2004-01-30 EP EP10075510.7A patent/EP2341134B1/en not_active Expired - Lifetime
- 2004-01-30 EP EP04707032.1A patent/EP1594962B1/en not_active Expired - Lifetime
- 2004-01-30 KR KR1020057014186A patent/KR20050109934A/ko not_active Application Discontinuation
- 2004-01-30 US US10/768,976 patent/US7238842B2/en not_active Ceased
- 2004-01-30 AU AU2004211584A patent/AU2004211584B2/en not_active Ceased
- 2004-01-30 CA CA002514564A patent/CA2514564A1/en not_active Abandoned
- 2004-01-30 EP EP10075509.9A patent/EP2369006B1/en not_active Expired - Lifetime
- 2004-01-30 EP EP11005044.0A patent/EP2455457B1/en not_active Expired - Lifetime
-
2007
- 2007-04-12 US US11/786,792 patent/US7867726B2/en not_active Expired - Lifetime
-
2008
- 2008-09-17 US US12/284,010 patent/USRE42931E1/en not_active Expired - Lifetime
-
2010
- 2010-12-21 US US12/975,020 patent/US8257939B2/en not_active Expired - Lifetime
-
2012
- 2012-04-18 US US13/450,217 patent/US8921620B2/en not_active Expired - Lifetime
- 2012-04-18 US US13/450,233 patent/US8895787B2/en not_active Expired - Lifetime
-
2014
- 2014-12-29 US US14/584,834 patent/US9540402B2/en not_active Expired - Lifetime
-
2016
- 2016-12-12 US US15/376,139 patent/US10240184B2/en active Active
-
2019
- 2019-03-20 US US16/359,581 patent/US11028424B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11028424B2 (en) | Covalent tethering of functional groups to proteins | |
US9873866B2 (en) | Mutant dehalogenase proteins | |
ZA200506120B (en) | Covalent tethering of functional groups to proteins |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |