KR20050030912A - Skin ointment and cosmetic component with contained illite - Google Patents

Abstract

Skin ointment and cosmetic composition comprising illite are provided, which composition has improved skin relieving activity, skin immunity reinforcing activity, and antimicrobial, antiviral and antifungal activity. The skin ointment comprising high pure illite is prepared by pulverizing illite to 2 to 14 micron, heating the pulverized illite at 150 to 300 deg. C to remove impurities, and mixing the heated illite with 2 to 11 wt.% of glycerin ointment. The cosmetic composition comprising high pure illite is prepared by pulverizing illite to 2 to 14 micron, heating the pulverized illite at 150 to 300 deg. C to remove impurities, and mixing the heated illite with 2 to 11 wt.% of cosmetic cream base, wherein the cream base comprises aloe berry and Tribulus terrestris L. juice.

Description

Skin ointment and cosmetic component with contained illite}

  The present invention relates to external skin ointments and cosmetic compositions containing illite that is sedating against antibacterial, antiviral, and particularly atopic dermatitis.

  Conventionally, various types of skin ointments and cosmetic compositions having sedative effects against antimicrobial, antiviral and atopic dermatitis have been known, but atopic dermatitis, which is spreading nowadays, is due to the development of new skin diseases with the development of industrial society. Because of its kind, the treatment had the following difficulties.

  As a treatment method to act directly on the skin, it can be divided into a method of washing, a method of applying a moisturizer, a method of applying an ointment such as steroids and the like.

  The cleaning method is to take a shower and bath to keep the skin clean, which is to remove dust, house dust mites, harmful bacteria, sweat and other foreign substances on the skin, thereby removing the deterioration factors of atopic skin. In particular, if you sweat a lot, it is necessary to wash well, and if you do not wash properly without excessive cleaning, the skin condition was worse.

  And applying moisturizer is very important in skin care, but atopic skin is very dry, so it is necessary to apply proper moisturizer. If you can't do that, you'll get worse. If the skin heals, there is a risk of recurrence.

  And the application of steroids and ointment is mainly used in the case of heart disease symptoms such as inflammation. Such steroids are a type of corticosteroids that have a healing effect, but if they are used for a long period of time, they have side effects that can be prevented.

  In addition, when the skin condition is very severe or scratched, sores or inflammations occur, it is common to use steroid ointment temporarily. The common side effects of steroids include skin atrophy, vasodilation, discoloration, and purpura. Deterioration of the skin caused capillaries to appear in the lungs and resistance to the use of the treatment was less effective.

  The present invention has been made to solve the above problems, and the gist of the present invention is to finely crush the illite into a range of 2 to 14 microns with a jet mill and then sterilize with heat of 150 to 300 ℃ and then to ordinary glycerin ointment 2 to 11 The elite ointment with a purity of 0.05 to 0.25% is mixed with the aforementioned illite at a ratio of 2 to 11:30 by weight. In addition, when the above-mentioned illite is mixed with a conventional cosmetic cream base at a weight ratio of 2 to 11: 100, the glycerin and steroid ointment can be used to increase the therapeutic effect thereof, thereby reducing the amount of use by showing a rapid improvement. Simultaneous side effects of steroids can be minimized and when used as an adjunct to the existing cosmetic cream base, it is possible to maximize the treatment of atopic dermatitis and skin beauty effects.

  The composition of the illite-containing skin external ointment and cosmetic cream base of the present invention minimizes the side effects of steroid ointment and increases its efficacy, and also has excellent skin action, adsorption and moisturizing power, and is used as an external skin ointment or cosmetics additive. It is intended to obtain excellent sedative effects on atopic dermatitis and various skin problems. The term "illite" herein refers to the chemical composition (K, H, O) Al (SiAl) O (HO, OH) clay minerals. It is a kind of subsidiary ingredient, Fe, FeMg, monoclinic system, 1 ~ 2, specific gravity is 2.6 ~ 2.9, color is white, gloss is earthy, early mating is white, and cleavage is perfect in one direction. It is very similar in chemical composition to muscovite, but lacks alkali ions between layers. For this reason, the deficiency is considered to be supplemented with hydronium ions.

  Illite is used as a generic term for fine white mica, and because it contains chemical composition and other crystallographic properties, it is not recognized as an independent mineral name. It is widely distributed in shale, acidic volcanic rocks, igneous sedimentary rocks, metamorphic rocks of origin, and ferric sedimentary rocks.

  Thus, illite refers to the soft clay mica in the form of fine clay in sedimentary rock layers. The mica here is a fungal mineral containing potassium and aluminum, which was first discovered in Illinois, USA, so it was named "Ilite" after the province.

  As a characteristic of the illite, the outside of the multi-layered structure is translucent plate-like flakes, so the adhesion and elasticity of the skin is good and it does not lump, so it is excellent in adhesion to the skin. In addition, it absorbs and decomposes various heavy metals and organic substances on the skin, activates cells, enhances immunity, and enhances natural healing power. It has excellent antibacterial and antifungal effects and is already used as a water quality improvement and treatment agent. It emits 93% of far infrared rays at 40 ° C and emits a large amount of negative ions.

  And since illite is composed of pure natural minerals, it has no addictive and no side effects, and it has an pharmacological function of effectively adsorbing and removing organic substances or toxic substances from the skin, and pharmacologically acting directly on cells to increase immunity and increase natural healing ability.

  Atopic dermatitis is a new environmental disease caused by an increase in irritants such as industrial pollution and an increase in allergens. There is no doubt that allergic reactions are one of the causes of the disease, but the immunological aspects alone cannot explain the various clinical manifestations and symptoms of atopic dermatitis. According to recent research results, it is worth noting that the abnormality of the skin barriertunction, which is an inherent function of skin, is explained as one of the important requirements as a cause of atopic dermatitis. Understanding the characteristics of dermatitis and the development of atopic dermatitis, which focuses on the recovery of skin barrier function, needs to be considered.

  The application of moisturizer is to apply glycerine ointment or cosmetics because it moisturizes dry skin, which is a very important part in the management of atopic skin along with cleaning. Because atopic skin is very dry, it is necessary to apply an appropriate moisturizer, or it may worsen the skin condition.

  And even after the skin has improved, it is necessary to take long-term prevention with steady use. Commercially available methods of applying ointments such as steroids are often used when severe symptoms such as inflammation, steroids are a kind of corticosteroids, but the effect is very good, but caution should be used. If the symptoms are not severe, it is desirable to refrain from using it. When the skin condition is very severe or scratched or wounded or inflamed, it is necessary to use it only temporarily to minimize the side effects.

  And common side effects for steroids include skin atrophy, vasodilation, discoloration, and purpura, and worsen skin. This worsened skin may reveal capillaries. In addition, there is a case that the resistance of the germ to the drug is used, the less effective the use, and the rebound phenomenon (recurrence) due to discontinuation.

  Therefore, when used as an excipient in glycerine and steroid ointment and atopic dermatitis cosmetics, the effect of glycerine and steroid ointment is increased to show a rapid improvement, thereby reducing the amount of steroid used to reduce side effects of steroids. It also minimizes rebound by its antibacterial antiviral antifungal effect. In addition, although the effect is shown to be increased even when used in combination with the existing atopic dermatitis cosmetics, this is due to the adsorption, fast absorption, antimicrobial antiviral and antifungal efficacy of the "illite" Matched with cosmetics function, it appeared to act quickly.

[1] A method for producing an ointment-containing skin external ointment composition of the present invention and a method for producing a cosmetic cream base composition are as follows.

  First, in the method for producing an ointment-containing skin external ointment composition of the present invention,

  First step—Commercially available commercial illite is pulverized in the range of 2 to 14 microns using a jet mill grinder and then sterilized with heat of 150 to 300 ° C.

  Step 2-The commercially available glycerine ointment is mixed with the illite obtained in the first step in a ratio of 2 to 11:30 by weight, or 2 to 11% by weight with a commercial steroid (purity 0.025 to 0.5%). .

  3rd process-What is obtained in the 2nd process is packaged by dividing a predetermined quantity in a container.

Next, in the method for producing a cosmetic cream base composition of the present invention,

  Step 1—Commercially available commercial illite is pulverized in the range of 2 to 14 microns with a jet mill grinder, followed by water removal and sterilization at 150 to 300 ° C.

  2nd process-2-11 weight% of the illite obtained by the said 1st process is mixed with a conventional cosmetic cream base, or 2-10 weight% of the illite is mixed with the said cosmetic cream base, but it is usual for the cream base mixed with this Aloe berry (water content of 30-50%) and baekchilyeo juice (water content of 30-50%) are respectively mixed in a 50:50 weight ratio.

  3rd process-The product obtained in the 2nd process is packaged in a container.

  And when explaining the embodiment of the present invention.

 (1) Example 1 of the production method of illite-containing glycerin ointment composition.

  Step 1-Commercially available commercially available high purity illite (suitable for grinding) is pulverized with a jet mill to 6-7 microns and heat-treated at 250-300 ° C. to completely remove moisture and impurities, which is then used for conventional glycerin ointment. 2% by weight of the glycerol ointment containing illite.

 (2) Example 2 of the illite-containing glycerin ointment preparation method.

  The illite of the first embodiment is mixed with ordinary glycerin ointment by 5% by weight to obtain an illite-containing glycerin ointment.

 (3) Example 3 of the illite-containing glycerin ointment preparation method.

  The illite of the first embodiment is mixed with normal glycerin ointment 11% by weight to obtain an illite-containing glycerin ointment.

 (4) Fourth Example of illite-containing glycerin ointment preparation method.

  A elite slit of high swash plate was pulverized to a size of 12 to 14 microns using a jet mill, and then heat treated at a high temperature of 250 to 300 ° C. to completely remove moisture and impurities, and then mixed with a 2% by weight of ordinary glycerin ointment. Obtain a light-containing glycerin ointment.

 (5) Example 5 of the illite-containing glycerin ointment preparation method.

  The illite of the fourth embodiment is mixed with ordinary glycerin ointment by 5% by weight to obtain an illite-containing glycerin ointment.

 (6) Example 6 of the elite-containing waselin preparation ointment.

  The illite of the first embodiment is mixed with normal glycerin ointment 11% by weight to obtain an illite-containing glycerin ointment.

[1-1] Experimental Example 1 was selected from 30 men and women aged 5 to 20 years old with elite glycerin ointment with atopic dermatitis, and divided into 10 groups, each group, group, and group, in Examples 1 to 3 above. The obtained illite-containing glycerin ointment was applied three times a day for two weeks. The selected a, b, and multi group were for patients who came to the hospital, and no other medication was combined. (Family is the first embodiment, Nag is the second embodiment, and Multi is the third embodiment)

  In Experimental Example 2, the ointments obtained in Examples 4 to 6 were sequentially divided into groups A, B, and C. Apply weekly. (Group A is Example 4, Group B is Example 5, Group C is Example 6) The selected Groups A, B, and C were for patients who were admitted to the hospital. .

<Experimental Results> The results of the visual inspection by the skilled practitioners of the clinical results classification are shown in Table 1 after 2 weeks.

TABLE 1

Symptom test group Worsening symptoms Relief of symptoms Symptom relief No response Remarks Gagun 4 6 Symptom Improvement 40% Me 3 5 2 Symptom Improvement 80% Group 5 4 One Symptom Improvement 90% A group One 2 7 20% improvement in symptoms B group 2 3 5 50% improvement in symptoms Group C 3 3 4 Symptom Improvement 60%

  As shown in Table 1, Glycerin Ointment 2-11: 30 weight ratio was used for 2-7 micron illite. Has a pronounced effect. Groups A, B, and C, who used glycerin ointment in a 2 to 11: 100 weight ratio of 8-14 microns of illite, doubled the particle size, had an average symptom effect of 43%. As can be seen from the above experimental results, it was found that illite is effective in alleviating the symptoms of atopic dermatitis on its own, and the important fact is that the effect is more pronounced as the particles are atomized and the higher the mixing ratio of the illite.

  In addition, no adverse effects were observed in the test subjects during the experiment, indicating that the illite mixture of the present invention was safe for the skin.

[2] In the following, the effects of atopic dermatitis on the steroid ointment were mixed through Examples and Experimental Examples.

  Example 1: A conventional high purity illite is ground to a particle size of 6 to 7 microns using a jet mill. The pulverized illite is heat treated at 250 to 300 ° C. to completely remove moisture and impurities.

  Example 2: 30 g each of a normal steroid ointment (0.1% purity) was contained and nothing was mixed.

  Example 3: The illite obtained in Example 1 was mixed with 2 wt% of illite in a normal steroid ointment (0.1% content).

  Example 4: 5 wt% of the illite (Example 1) was mixed with a conventional steroid ointment (0.1% purity).

  Example 5 11 wt% of the illite (Example 1) was mixed with a conventional steroid ointment (0.1% content).

Experimental Example 1-1 Ten men and women aged 5 to 20 years old with atopic dermatitis were selected as "family", and Example 2 ointment was applied three times a day for two weeks. Ten selected patients were included in the hospital, and no other treatment was performed.

<Experimental Example 1-2> A group of 5 to 20 years old males and females with atopic dermatitis were selected and mixed in Example (3, 4, 5) in order of 10 persons each divided into A group, B group and C group. The ointment was allowed to apply three times a day for two weeks. Groups A, B, and C were selected for the patients who visited the hospital.

<Experimental Results> Two weeks later, the results of the survey and symptom improvement by the skilled practitioner of the results were confirmed by the subjects.

TABLE 2

       Symptom Experiment Group Worsening symptoms Relief of symptoms Symptom relief No response Remarks Gagun 2 3 5 Symptom improvement 50% Group A (Example 3) 4 4 2 Symptom improvement 80% Group B (Example 4) 4 5 One Symptom improvement 90% C group (Example 5) 5 4 One Symptom improvement 90%

  As a result of Table 2, steroid ointment alone showed 50% symptom improvement effect. This is commonly the case for atopic dermatitis and is one of the easiest treatments. However, it is also a treatment that patients are reluctant to worry about side effects after long-term use.

  However, if you look at the results of groups A, B, and C, the improvement of symptoms can be seen more clearly when illite is mixed with steroid ointment. Clear symptom relief is more than 1.6 times higher than without illite. It has also been shown that the finer the particle size of the illite and the greater its amount, the more effective it is.

  Table 3 below is a supplementary description of the symptoms change over time after application.

TABLE 3

     Time experiment group 5 minutes after application 10 minutes after application 20 minutes after application 30 minutes after application No response Gagun 5 5 A group 3 5 2 B group 5 4 One Group C 7 2 One

  According to the results of Table 3 above, when only steroid ointment is used, symptoms usually improve after 10 minutes. However, when the illite is mixed, the symptoms improve after 5 minutes. This indicates that the combination of elite ointment with steroid ointment has a rapid symptomatic effect. Also, as the amount of illite increased, the symptom improvement effect was faster.

  And as a result shown in Tables 1 and 2 above, the use of illite mixed with steroid ointment instead of glycerin ointment can be seen that the symptom improvement effect and speed is faster than the glycerin ointment is mixed. This is a revolutionary invention that reduces the existing amount of steroid ointment and at the same time helps to improve symptoms quickly, which is good news for patients who are reluctant to use steroid ointment due to the side effects of steroids.

[3] Next, experiments were conducted on the effects of atopic dermatitis through examples and experiments performed by mixing illite in a general cosmetic cream base.

  Example 1: A conventional high purity illite is ground to a particle size of 6 to 7 microns using a jet mill. The pulverized illite is heat treated with 250 to 300 ° C. to completely remove moisture and impurities.

  Example 2 Purchasing a commercially available cosmetic cream base is divided into 100g each in a transparent container.

  Example 3: 2 wt% of the illite obtained in Example 1 is mixed with the cosmetic cream base prepared in Example 2.

  Example 4 5 wt% of the illite obtained in Example 1 is mixed with the cosmetic cream base prepared in Example 2.

Experimental Example 1-1 Ten men and women aged 5 to 20 years with atopic dermatitis were selected as the "A" group, and Example 2 was applied to cream base only three times a day for 4 weeks. Ten selected patients were included in the hospital, and no other treatment was performed.

<Experimental Example 1-2> 20 people 5 to 20 years old men and women with atopic dermatitis were selected as group A and group B, respectively, and the mixtures of Examples 3 and 4 were sequentially applied three times a day for 4 weeks. It was made. The 20 selected patients were included in the hospital, and no other treatments were performed.

<Experimental Results> The results of the results of 4 weeks after the questionnaire survey and symptom improvement by the clinical results classification practitioners were as follows.

TABLE 4

     Symptom control Worsening symptoms No response Relief of symptoms Symptom relief Remarks Gagun 7 3 Symptom improvement A group 3 2 5 Symptom Improvement 70% B group 2 3 5 Symptom improvement 80%

  In Table 4, the group using only cream base showed only slight or no response, whereas group A with cream base mixed with 70% symptom improvement and group B showed 80% symptom improvement. . In addition, as the particle size of the illite is further micronized and the amount is increased, the effect is higher.

  As can be seen from this experiment, illite has been found to be effective in atopic dermatitis as a cosmetics subsidiary. Nowadays, the trend is to prefer natural-friendly materials, and when used as an excipient in skin problems such as atopic dermatitis, it will be spotlighted as a functional natural cosmetic.

  As a result of the total experiments so far, when the illite of the present invention is used as an external preparation for skin, it means that atopic dermatitis and various skin problems caused by internal or external factors can be effectively improved. In addition, no adverse effects were observed in the subjects during the experiment, indicating that the mixtures of the present invention were safe for the skin.

[4] The following are examples and experimental examples of mixing aloe berry and white herbal herbal juice (45-60% water content) when the illite is mixed with the cosmetic cream base. This study examined the effects of mixing herbal medicine to treat atopic dermatitis.

Example 1 A typical high-purity elite is ground to a particle size of 6-7 microns with a jet mill and heat-treated at 250-300 ° C. to completely remove moisture and impurities.

<Example 2> 50:50 weight ratio of aloe berry (water content 30-50%) which is effective for normal skin beauty was mixed with white jigyeo (water content 30-50%) which is effective for acne treatment.

Example 3 20 wt% of the mixture obtained in Example 2 was mixed with a conventional cosmetic cream base.

Example 4 5 wt% of the illite of Example 1 was mixed with the mixture obtained in Examples 2 and 3.

<Experimental Example 1> Patients with severe atopic dermatitis and acne were selected from 30 to 5 years old and 20 years old males and 10 females, respectively. And group A and group B were applied in Example 4 three times a day for 4 weeks. The 30 selected patients were included in the hospital, and no other treatment was performed.

<Experiment> After 4 weeks, the results of the survey by the skilled practitioner of the clinical result classification for the test subjects and the improvement of symptoms are shown in Table 5.

TABLE 5

     Symptom control Worsening symptoms No response Relief of symptoms Symptom relief Remarks Gagun 8 2 Symptom improvement A group 2 3 5 80% B group One 5 4 90%

  As shown in Table 5, the "A" group, which is not mixed with herbal herbal medicine solution, showed weak symptom improvement, and the group A and B, which were mixed with herbal herbal medicine solution, showed 80 ~ 90% symptom improvement. This can be seen that Table 5 has a higher effect than when herbal medicine juice is not mixed as shown in Table 4 above.

  As described above, the particle size of the illite contained in the preparation of the external skin ointment and the cosmetics is in the range of 2 to 14 microns and the content thereof is in the range of 2 to 12% by weight, but preferably 5 to 11% by weight. A clear effect could not be expected in the dissolution of illite content less than 2% by weight, and in the dissolution of 12% by weight or more, more and more obvious effects could be expected. There was a tendency to cure upon this long-term use.

  As described above, in the present invention, in formulating ointments and cosmetics that soothe atopic dermatitis and various skin problems, a proper amount of glycerin ointment and steroid ointment and natural light illite powder are mixed in the cosmetic cream base, It is a very useful invention because it can greatly contribute to the strengthening of skin immunity and promoting public health such as antibacterial, antiviral and antifungal.

Claims (4)

  The elite-containing skin external ointment is characterized by pulverizing high purity illite into a size of 2-14 micron with a jet mill and heat treatment at 150-300 ° C. to completely remove impurities, and then mixing it in the glycerin ointment with 2 to 11% by weight. Composition.   The composition of the external topical ointment containing elite according to claim 1, wherein the illite is mixed in an amount of 2 to 11% by weight with steroid ointment having a purity of 0.025 to 0.5%.   An illite-containing cosmetic composition, characterized by mixing 2-11% by weight of an illite crushed to 2 to 14 microns and then heat treated at 150 to 300 ° C. in a conventional cosmetic cream base.   The method according to claim 3, wherein the illite is mixed 2 to 11% by weight in a conventional cosmetic cream base, but in the cosmetic cream base aloe berry (moisture content 30-50%) and baekryegi juice (moisture content 30-50%) The composition of the illite-containing cosmetics, characterized in that 10 to 30% by weight of the mixture mixed in a 50:50 weight ratio.