KR20050020407A - Topical composition using antiperspirants and deodorants having gold powder - Google Patents

Abstract

PURPOSE: A topical deodorizing composition comprising gold powder is provided, which composition inhibits generation of sweat, and thus inhibits odor caused by sweat, and has low skin stimulation, so that the composition is useful as external skin formulations. CONSTITUTION: The topical deodorizing composition comprises 0.001 to 5 wt.% of gold powder and 0.1 to 60 wt.% of aluminum chlorohydrate, wherein the topical deodorizing composition further comprises 0.1 to 10 wt.% of green tea extract; the topical deodorizing composition further comprises 0.1 to 10 wt.% of Paeonia suffruticosa Andrews. extract; the topical deodorizing composition further comprises a pharmaceutically acceptable additive selected from gelating agent, preservative, pain eliminating agent, stabilizing agent acid and alkalization agent; and the topical deodorizing composition has a formulation selected from oinment, cream, lotion, liquid and spray.

Description

Topical composition using antiperspirants and deodorants having gold powder}

The present invention relates to a limited-dose external preparation composition containing gold powder and aluminum chlorohydrate, and more particularly, to contain the antiperspiranting effects of inhibiting sweat occurring in the human body by containing gold powder and aluminum chlorohydrate as active ingredients. The present invention relates to an external preparation composition having excellent deodoranting effects on unpleasant body odors and odors generated by sweating and the like.

The skin surrounding the human body has minute pores and numerous skin pores that regulate body temperature. Especially around the hair roots, fat glands are developed, which constantly release fat and release sweat. Therefore, in the summer, even in the same daily activities, a lot of sweat. Excessive sweating can damage the skin, which can result in severe odors and collection. In addition, unpleasant odors occur throughout the body due to exercise, aging, and specific constitutions. In general, such body odors are generated when sweat secreted by exercise is decomposed by the action of microorganisms or enzymes. will be. These unpleasant odors have been disgusting in human life and many attempts have been made to deodorize these odors.

As an example, the addition of a substance that suppresses sweat secretion or direct or indirect microbial inhibitors or enzyme inhibitors such as ethyl lactate, octyl crotonate, triethyl citrate to prevent the decomposition of secreted sweat Methods have been used. In addition, there have been attempts to use antioxidants such as BHA and BHT in view of the fact that oxides such as a large amount of unsaturated compounds included in sebum contribute to the generation of odors. In addition, a method of adding a method for use in herbal medicine or folk, such as green tea extract or rosin composition has been prepared.

However, these conventional methods have a weak limiting and deodorizing effect, and also cause serious problems on the skin such as irritation to the skin and redness, making it difficult to use in the clinic.

In addition, attempts have been made to mask or suspend malodors using pure perfume substances and powders, but there is a limit to the deodorization of body odors.

Gold (Au) used in the present invention is a material closely related to human life. The atomic number is 79, the melting point is 1.064 ° C, and 1 g of gold has an area of 4,900 cm 2, and the thickness is 0.1 μm. It is thin and very fine. Gold has many beneficial effects on the human body. Especially, in Dong Bogam, gold is known to help nerve stabilization and detoxify toxic substances. It is also known to treat asthma and rheumatoid arthritis, circulatory diseases and skin cleansing. However, in the consent book, there is only a description that it is effective for skin diseases such as boils, dog venom, ulcers, fire poisons, purulent purpura, and there are no descriptions or references used for restriction deodorization. Around 1890, Koch was found to inhibit the growth of M. tuberculosis bacteria, and Forestier proved its excellent effectiveness in treating chronic arthritis rheumatism. Widely used. In recent 1980s, oral contraindications (Auranofin) have been clinically used in Germany, and the number of them has been spreading. Recently, a Korean brewing company has developed a liquor containing gold powder and is getting a good response. However, no prescription or study mentions the use of gold for limiting deodorization.

Accordingly, the present inventors conducted repeated studies to develop a new, effective deodorizing external preparation composition. As a result, the addition of gold powder, which shows various beneficial effects to the human body, to the known aluminum chlorohydrate preparations significantly increased the limiting and deodorizing effects. It has been found that the present invention has been completed.

An object of the present invention is to solve the problems of the prior art as described above, to suppress the sweat generated in the human body, to provide an external preparation composition having an excellent deodorant effect on unpleasant body odor and odor.

In order to achieve the above object, the present invention provides an external composition for deodorization containing gold powder and aluminum chlorohydrate.

The composition may be provided in the form of an ointment, cream, lotion, liquid or spray.

The present invention is described in more detail as follows.

The active ingredient of the present invention contains gold powder, the content of which is preferably 0.001-5% by weight based on the total weight of the composition. If the content of gold powder is less than 0.001% by weight, it is difficult to achieve the desired limiting and deodorizing effects of the present invention, and when it is more than 5% by weight, it is not preferable in terms of cost.

In the present invention, "gold powder" refers to powdered gold, which is powdered by pulverizing gold by a conventional method, or powdered by thinning by rolling or the like. As the gold powder used in the present invention, it is preferable to use a gold powder having a particle size of 500 microns or less, more preferably a gold powder having a particle size of 100 microns or less, particularly preferably 30 microns or less.

The present invention also contains aluminum chlorohydrate as the active ingredient, the content of which is preferably 0.1 to 60% by weight based on the total weight of the composition. If the content of aluminum chlorohydrate is less than 0.1% by weight, it is difficult to achieve the desired limiting and deodorizing effect of the present invention, and when it exceeds 60% by weight, there is no increase in efficacy and is inappropriate.

The aluminum chlorohydrate used in the composition of the present invention is a substance which suppresses sweating by shrinking pores, and many known aluminum chlorohydrate preparations are known for obtaining a sweating action. However, in the case of known aluminum chlorohydrate preparations, the effect of aluminum chlorohydrate alone is not sufficient to obtain a sufficient deodorizing effect, and simply suppressing sweating is insufficient to obtain a desired effect. In the present invention, gold powder is mixed with an aluminum chlorohydrate, for example, a common aluminum chlorohydrate preparation, thereby increasing the deodorizing effect of a known aluminum chlorohydrate preparation, as can be seen in the following experimental example.

In the composition of the present invention, it may further contain a green tea extract, the content of the green tea extract is preferably 0.1 to 10% by weight relative to the total composition weight.

In addition, the composition of the present invention may further contain an extract of Moutan Cortex Radicis, the content of the extract is preferably from 0.01 to 10% by weight based on the total weight of the composition.

The green tea extract and the extract of bark skin are water, methanol, ethanol, propanol and other C _1-4 alcohols, ethyl acetate, chloroform, using conventional methods used for herbal medicine extraction, distillation, sonication, etc. Extract from an organic solvent such as CH ₂ Cl ₂ or a mixture thereof.

As described above, the composition of the present invention may further contain green tea extract and / or bark extract, and in particular, when the bark extract is added, the limit and deodorization effect are excellent.

In addition to the above, the composition may further contain a pharmaceutically acceptable additive, and may be added at least one of a gelling agent, a preservative, a painless agent, a stabilizer, an acid or an alkalizing agent, and the like. Those skilled in the art will be able to use any of the commonly available gelling agents, preservatives, stabilizers, analgesics, acids or alkalizing agents.

The compositions of the present invention may be prepared in the form of ointments, creams, lotions, liquids or sprays, and the compositions are applied or sprayed onto the skin for restriction deodorization. The amount of the composition to be applied is determined in consideration of the amount that can cause and sustain the deodorizing effect, and it is preferable to use an amount in the range of 0.1 to 0.5 grams once, but a specific dosage level for a specific individual may be used as an active ingredient May vary depending on the content ratio, weight, sex, health condition, diet, time of administration, method of administration, rate of excretion, sweating and odor.

The external preparation composition according to the present invention may be prepared by mixing each component in a conventional manner, and other substrates may be mixed, aluminum chlorohydrate and gold powder may be added to the mixture, and other additives may be mixed and stirred to prepare the composition. have.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, the examples are described for the purpose of illustrating the present invention, and the present invention is not limited to the examples.

Example 1 and Comparative Example 1

In the component ratio of the following Table 1, Benton 38 and SD alcohol 40 were added while stirring isopropyl myri stay, and it stirred continuously. Aluminum chlorohydrate was slowly added while stirring the mixture, and gold powder was further added. Perfume was added and stirred for an additional 15 minutes to form a mixture. Propeller A-46 was added as a mixture and a propeller, and an aerosol was prepared by filling in an aluminum can, which was used as Example 1. The composition can be applied to the skin of interest by using the injection force of the compressed gas, it is possible to dose the correct amount of liquid using a metered dose valve (metered dose valve). The unit of each component amount means the weight percentage of each component in the total composition. Also, except for the gold powder, Comparative Example 1 was prepared in the same manner as in Example 1.

Table 1

Ingredient Example 1 Comparative Example 1 Aluminum Chlorohydrate 10 10 Gold powder 0.01 - Isopropyl myristate 13 13 Benton 38 One One SD Alcohol 40 Anhydride One One Propeller A-46 73.99 74 Spices One One system 100 100

Example 2

Each component was mixed in the component ratios shown in Table 2 below, propane / isobutanol was added to propane and filled in an aluminum can to prepare an aerosol.

TABLE 2

Ingredient Example 2 Aluminum Chlorohydrate 2.5 Gold powder 0.1 Green tea extract 1.5 Talc 0.5 Bentonite 0.1 IPM 2.5 Siloxane 5.0 Copolymer 0.2 Isostearyl Alcohol 0.3 Spices 0.1 Propane / isobutanol 87.5 system 100

Example 3

In the following component ratios, Benton gel VS-5 / PC and siloxane SWW-03315 were mixed with stirring, aluminum chlorohydrate and gold powder were added and stirred for an additional 15 minutes. After adding silica and fragrance to the mixture, the mixture was stirred for 10 minutes, homogenized, and placed in a suitable container to prepare a suspension roll-on formulation, which was used in Example 3.

TABLE 3

Ingredient Example 3 Aluminum Chlorohydrate 20 Gold powder 2 Benton Gel VS-5 / PC 13.5 Siloxane SWW-03315 63 Silica 0.5 Spices One system 100

Example 4

By mixing each component in the component ratio of the following Table 4 to prepare a suspension roll-on (roll-on) was prepared as Example 4.

Table 4

Ingredient Example 4 Aluminum Chlorohydrate 45 Gold powder 0.004 Process AWS 2 Bark Extract 1.5 Natrosol 250MR CS 0.2 Deionized water 11.2 SD Alcohol 40 39.096 Spices One system 100

Example 5

At the component ratio shown in Table 5 below, siloxane F-222 was placed in a reaction vessel and heated to 65 ° C. To this was added promyristyl PM-3 and PEG-8 distearate with stirring. Stearyl alcohol was added slowly while maintaining 65 ° C., aluminum chlorohydrate and gold powder were added and stirred for an additional 10 minutes. Talc, silica and fragrance were added to the mixture, stirred, cooled to 54 ° C. and placed in a stick casing to prepare a stick agent, which was used in Example 5. Also, except for the gold powder, Comparative Example 2 was prepared in the same manner as in Example 5.

Table 5

Ingredient Example 5 Comparative Example 2 Aluminum Chlorohydrate 20 20 Gold powder 5 - Siloxane F-222 50 50 Stearyl alcohol 15 20 Promyristyl PM-3 5 5 PEG-8 distearate 2 2 Talc One One Silica One One Spices One One system 100 100

Example 6

In the following component ratios of Table 6, each component was mixed to prepare a stick, which was used as Example 6.

Table 6

Ingredient Example 6 Aluminum Chlorohydrate 20 Gold powder 5 Siloxane F-222 50 Stearyl alcohol 15 Promyristyl PM-3 5 PEG-8 distearate 2 Talc One Silica One Spices One system 100

Example 7

In the following component ratios, Arlacel 165 and cetyl alcohol were heated to 75 ° C. while mixing. Sorbitol 70% solution and deionized water were mixed and heated to 75 ° C. Each mixture was mixed and then cooled to 55 ° C. and aluminumchlorohydrate and gold powder were added with stirring. Finally, the perfume was added and cooled to prepare a cream, which was used as Example 7. In addition, Comparative Example 3 was prepared in the same manner as in Example 7, except for the gold powder.

TABLE 7

Ingredient Example 7 Comparative Example 3 Aluminum Chlorohydrate 44.5 44.5 Gold powder One - Arasel 165 15 15 Cetyl alcohol 5 5 Sorbitol 70% solution 3 3 Deionized water 30.5 31.5 Spices One One system 100 100

Experimental Example 1 Limiting Deodorizing Force Measurement Test

The limiting odor of the compositions of Examples 1 to 7 and Comparative Examples 1 to 3 was measured. After selecting 50 males and 50 females of 20 to 60 years, who are usually sweaty, have an unpleasant smell, and feel that their collection is unpleasant to others, Examples 1 to 7 and Comparative Examples 1 to 1 were selected. After applying the composition of 3 to the sweaty part of the bran and the foot, 20 sensory evaluation specialists to evaluate the sensory difference according to the limits and deodorant labeling method shown in Table 8 below, the results are shown in Table 9 Indicated.

Table 8

Evaluation standard Display contents Limited effect Deodorant effect Dryness 5 Very good Very good Very good 4 good good good 3 Slightly Slightly Slightly 2 Has a slight effect Has a slight effect Has a slight effect One None at all None at all None at all

Table 9

sample Rating (panel self-evaluation) Rating (evaluated by evaluation specialists) Limited effect Deodorant effect Skin texture Limited effect Deodorant effect Skin texture Example 1 4.1 ± 1.3 4.2 ± 1.2 4.1 ± 1.5 4.2 ± 1.3 4.2 ± 1.1 4.1 ± 0.4 Example 2 3.7 ± 1.5 3.8 ± 2.1 3.7 ± 0.9 3.6 ± 0.9 3.8 ± 1.3 3.8 ± 0.6 Example 3 4.2 ± 1.0 4.3 ± 1.3 4.2 ± 0.8 4.3 ± 1.3 4.4 ± 0.7 4.1 ± 0.7 Example 4 4.9 ± 0.4 4.9 ± 1.1 4.8 ± 1.5 4.9 ± 0.4 4.9 ± 1.3 4.8 ± 0.9 Example 5 4.4 ± 1.1 4.5 ± 1.5 4.3 ± 1.3 4.2 ± 0.3 4.5 ± 0.6 4.2 ± 1.1 Example 6 4.3 ± 1.2 4.5 ± 0.7 4.2 ± 0.9 4.2 ± 0.7 4.4 ± 0.7 4.2 ± 1.4 Example 7 4.7 ± 0.8 4.6 ± 1.5 4.7 ± 1.1 4.6 ± 1.6 4.6 ± 1.2 4.5 ± 0.6 Comparative Example 1 3.1 ± 0.6 3.1 ± 0.9 3.1 ± 1.6 2.9 ± 0.3 3.0 ± 1.1 2.9 ± 0.7 Comparative Example 2 3.5 ± 2.1 3.4 ± 1.5 3.5 ± 0.6 3.6 ± 0.2 3.5 ± 1.5 3.6 ± 1.5 Comparative Example 3 3.7 ± 1.8 3.5 ± 1.4 3.6 ± 0.7 3.9 ± 0.9 3.7 ± 1.2 3.8 ± 1.4

As shown in Table 9, the composition of the present invention is excellent in the limiting and deodorizing effect, it can be seen that the synergistic effect of the limiting and deodorization by using a combination of gold powder and aluminum chlorohydrate. In addition, the addition of green tea extract or bark extract was more excellent in limiting and deodorizing effect.

As can be seen from the above, the composition of the present invention has an excellent limiting deodorizing effect of suppressing the sweat generated in the human body, suppressing unpleasant body odor and odor caused by sweat, etc., and also low skin irritation, in particular for external skin preparation Can be used as

Claims (10)

External deodorant external preparation composition containing gold powder and aluminum chlorohydrate. The external preparation composition according to claim 1, wherein the content of gold powder is 0.001-5 wt% based on the total weight of the composition. The external preparation composition according to claim 1, wherein the content of aluminum chlorohydrate is 0.1 to 60 wt% based on the total weight of the composition. The external preparation composition according to claim 1, further comprising a green tea extract. The topical composition according to claim 4, wherein the content of green tea extract is 0.1-10% by weight based on the total weight of the composition. The external preparation composition according to claim 1, further comprising a extract of bark skin. The topical composition according to claim 4, wherein the content of the bark extract is 0.01-10 wt% based on the total weight of the composition. The external preparation composition according to claim 1, further comprising a pharmaceutically acceptable additive. The external preparation composition according to claim 8, wherein the pharmaceutically acceptable additive is a gelling agent, a preservative, a painless agent, a stabilizer acid or an alkalizing agent. The external preparation composition according to claim 1, wherein the composition is in the form of an ointment, cream, lotion, liquid or spray.