KR100738598B1 - A cosmetic composition for acne improvement - Google Patents

Abstract

A cosmetic composition for acne improvement is provided to inhibit growth of Propionibacterium acnes causing acnes, and improve safety to human body by reducing skin irritation. The cosmetic composition for acne improvement comprises 0.01-20.0 wt.% of caprylic/capric glyceride having antimicrobial activity against bacteria and yeast, and being contained in liver oil of shark or human sebum, and is formulated as soft lotion, astringent lotion, nutrition lotion, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, solid soap, liquid soap, powder, essence or pack.

Description

A cosmetic composition for acne improvement

The present invention relates to a cosmetic composition for improving acne, and more particularly, by containing caprylic / capric glycerides as an active ingredient, acne by inhibiting the growth of propionibacterium acnes, which is a cause of acne, A cosmetic composition effective for improvement.

In general, acne has an inflammatory response caused by stimulation of free fatty acids produced by lipase of propionibacterium acne, an excess of sebum secretion, excess keratinization, and anaerobic dermatitis. It is known as the cause. Drugs in the form of oral or external preparations have been used to treat acne, for example, anti-androgens that inhibit sebum production, nonsteroidal anti-inflammatory agents that act as anti-inflammatory agents, and lesocinols, sulfur, salicylic acid, and benzoyl peroxide. And antimicrobial agents such as isotretinoin, keratin release agents, tetracycline, erythromycin, and methods of inhibiting the activity of propionibacterium acne by antibiotics such as methacycline. On the other hand, recently, a treatment method using a vitamin A derivative such as retinoic acid and a skin method using azelaic acid are also widely used. In addition, a technology related to cosmetics effective for acne using myrrh, which has been used as a medicinal herb for a long time, was also introduced in Korea Patent Publication No. 95-8762 (Lee Jae-jae, etc.).

However, the methods described above have some results in acne treatment, but have some problems in terms of effectiveness, side effects, and usability. In other words, the use of hormonal agents has been reported to inhibit epidermal growth and other hormone abuse side effects, and keratin exfoliants such as retinoic acid and benzoyl peroxide may cause skin irritation and contact dermatitis due to exfoliation. The antibiotics mentioned above are known for the emergence of resistant bacteria and for the possibility of photosensitivity. In particular, isotretinoin is known to have a teratogenic effect on the fetus. In addition, cosmetic compositions effective for acne using conventional oriental herbal plant extracts, such as myrrh, may be effective in acknowledgment, but may have an allergic hypersensitivity reaction to acne-sensitive skin in some cases. I have a problem.

Therefore, the necessity of developing a safe and effective product for the human body in acne skin is steadily emerging.

The present invention relates to a cosmetic composition for improving acne having an effective effect on acne skin by adding caprylic / capric glyceride to a conventional cosmetic composition to inhibit acne-inducing bacteria Propionibacterium acne.

Hereinafter, the present invention will be described in more detail.

The inventors have found that caprylic / capric glycerides have an antibacterial effect on the acne bacterium propionibacterium acne, and the effect is also excellent. Caprylic / Capric glycerides are polar oils with affinity with surfactants of water and face washes, which have high safety and are used to make emulsifiers and microemulsions in formulations. It also has antibacterial activity against bacteria and yeast, and is contained in shark liver oil and human sebum.

In the present invention, caprylic / capric glycerides having an effective effect on acne skin by inhibiting acne bacteria are contained in an amount of 0.01 to 20.0% by weight, preferably 0.1 to 10.0% by weight, based on the total weight of the composition. A cosmetic composition for improving acne was constructed.

remind Caprylic Of Capric Glyceride  It can be purchased commercially and is not specifically limited. In the present invention, Sweden Karlshamns Four Akoline MCM Was used.

The cosmetic composition containing the caprylic / capric glyceride may be prepared in any formulation commonly prepared in the art, for example, softening cream, astringent makeup, nutrition cream, eye cream, nutrition cream, Massage cream, cleansing cream, cleansing foam, cleansing water, solid soap, liquid soap, powder, essence, packs and the like is not particularly limited in the formulation can be prepared according to the formulation or use of cosmetics.

The following is described in more detail with reference to the following embodiments of the present invention configured as described above. However, these examples are intended to illustrate the present invention, it is obvious to those skilled in the art that the scope of the present invention is not limited to these examples. Compounding amount is shown by weight%.

Experimental Example 1 Antimicrobial Effect of Caprylic / Capric Glyceride

In order to measure the antibacterial effect of caprylic / capric glycerides on acne, which is used in cosmetic compositions for improving acne, the samples described in Table 1, namely, tea tree oil, azelaic acid, ginseng plant extract, erythromycin, benzoyl Peroxhydr and caprylic / capric glycerides were added to the Brain heart infusion culture so as to be 10-10000 ppm, and then the culture was prepared in the liquid phase. After inoculating Propionibacterium Acne ATCC 6919 bacteria into the culture medium, the cells were incubated for 48 hours in an anaerobic condition at 35 ° C. and observed for the status of bacteria. The antimicrobial activity was measured as (MIC). The results are shown in Table 1.

Minimum Growth Inhibition Concentration (MIC) Sample Name MIC (ppm) Caprylic / Capric Glyceride 50 Tea tree oil 10000 Erythromycin 200 Azelia > 2000 Benzoyl peroxide 1000

As can be seen in Table 1, since the caprylic / capric glyceride has superior antimicrobial activity than others, the cosmetic composition using the same is expected to have an excellent acne healing effect.

In addition, in order to measure the acne skin effect and skin irritation of the acryl skin cosmetic composition containing caprylic / capric glyceride, the acne cosmetic composition is set to Examples 1, 2 and Comparative Examples 1 to 3, respectively, in a conventional method. It was prepared according to the above, and its composition is shown in Table 2 below.

Examples 1 and 2 and Comparative Examples 1 to 3 Ingredient Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Caprylic / Capric Glyceride 0.5 1.0 - - - Tea tree oil - - 1.0 2.0 - Propylene glycol 6.0 6.0 6.0 6.0 6.0 glycerin 4.0 4.0 4.0 4.0 4.0 Triethanolamine 1.2 1.2 1.2 1.2 1.2 Tocophenyl Acetate 3.0 3.0 3.0 3.0 3.0 Liquid paraffin 5.0 5.0 5.0 5.0 5.0 Squalane 3.0 3.0 3.0 3.0 3.0 Macadamia Nut Oil 2.0 2.0 2.0 2.0 2.0 Polysorbate 60 1.5 1.5 1.5 1.5 1.5 Sorbitan sesquioleate 1.0 1.0 1.0 1.0 1.0 Xanthan Gum 0.3 0.3 0.3 0.3 0.3 Incense, preservative a very small amount a very small amount a very small amount a very small amount a very small amount Purified water To 100 To 100 To 100 To 100 To 100

(Experimental example 2) comparative test

In order to compare the antimicrobial activity of the products 1, 2 and Comparative Examples 1 to 3 prepared above, smeared with propionibacterium acne ATCC 6919 in brain heart infusion agar plate medium to which nutrients necessary for growth of bacteria were added. Afterwards, the cosmetics of Examples 1 and 2 and Comparative Examples were prepared by concentration. It was deposited. Incubated for 48 to 72 hours in anaerobic condition at 37 ℃ and the minimum concentration of the sample in which the bacteria inoculated in the solid medium was recorded as the minimum growth inhibitory concentration (MIC) to measure the antimicrobial activity. The results are shown in Table 3 below.

Minimum Growth Inhibition Concentration (MIC) Test bacteria Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Propionibacterium acne ATCC 6919 0.05 0.03 0.2 0.1 > 2

As can be seen in Table 3, Examples 1 and 2, which are cosmetic compositions containing caprylic / capric glycerides, can see MICs significantly lower against acne-causing bacteria compared to Comparative Examples 1 to 3, and thus have an antimicrobial activity. It was found to be excellent. Therefore, the composition of the present invention can be effectively used for acne skin improvement.

Experimental Example 3 Measurement of Improvement on Acne

In order to confirm the effect of acne treatment of the present invention, 50 men and women aged 18 to 28 years old were divided into five groups, using Examples 1 and 2 and Comparative Examples 1 to 3 in the same manner as daily lotion use for 4 weeks. Based on the opinion of the user, the degree of improvement was determined according to the following evaluation criteria. The test results are shown in Table 4 below.

[Evaluation standard]

+++: Very good improvement.

++: Significant improvement.

+: A slight improvement.

±: No improvement but no weakening.

-: No improvement, rather weakened.

term Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 1 week + + ± ± ± 2 weeks + ++ ± + ± 3 weeks ++ +++ + + ± 4 Weeks +++ +++ + ++ ±

As can be seen in Table 4, it can be seen that the cosmetic composition containing the caprylic / capric glyceride (Examples 1 and 2) is superior to the acne improvement compared to Comparative Examples 1 to 3.

Experimental Example 4 Patch Test

20 subjects (mean age 29 years, age distribution 23-39) to measure the skin safety of the cosmetic composition containing the caprylic / capric glyceride of the present invention (Examples 1 and 2) and Comparative Examples 1 to 3 Skin patch experiment was performed on the upper arm using Examples 1 and 2 and Comparative Examples 1 to 3 for three). However, psoriasis, eczema, and other skin lesion holders, pregnant women, lactating or contraceptives, antihistamines, etc. were excluded from the experiment.

First, the test area was wiped with 70% ethanol, dried, and the prepared test material was added dropwise into the pin chamber (Finn chamber, 100x10, EPITEST, Finland) by 15 µg, and then airtightly wrapped on the inner part of the subject's forearm. The patch was marked for 24 hours, the patch was removed, and the test site was marked with a pen. After 1 hour and 24 hours after the marking, the magnification (8MC-150, DAZOR, United States of America) was used to observe the test site, and erythema and edema were observed.

The skin response was determined according to the regulations of the International Contact Dermatitis Research Group (ICDRG), and the mean skin response rate was calculated according to Equation 1. The results are shown in Table 5.

* Evaluation criteria and score of skin reaction

sign score Evaluation standard - 0 No response ± 0.5 Faint or light erythema + One Boundary but weak erythema, edema and papules ++ 2 Pronounced erythema, papules and vesicles +++ 3 Severe erythema and alveolar, scleroderma

(Equation 1)

Mean skin responsiveness (mean score) = (score × number of responses × 100 × 1/2) / [3 (maximum score) × total number of subjects (n)]

Test substance After 1 hour After 24 hours Reactivity (%) (n = 20) ± + ++ ± + ++ Example 1 One - - - - - 0.42 Example 2 2 - - - - - 0.83 Comparative Example 1 2 - - - - - 0.83 Comparative Example 2 2 - - One - - 1.25 Comparative Example 3 One - - - - - 0.42

As can be seen in Table 5, the cosmetic composition containing the caprylic / capric glyceride of the present invention (Examples 1 and 2) is similar to Comparative Example 3 and the degree of irritation to the skin is almost no skin irritation Able to know.

Hereinafter, various formulation examples for the cosmetic composition containing caprylic / capric glyceride of the present invention are prepared according to a manufacturing method in a conventional cosmetic field. However, the composition of the present invention is not limited to the following formulation examples.

Formulation Example 1 Manufacturing Flexible Cosmetic (Skin)

To prepare a flexible lotion containing caprylic / capric glyceride of the present invention, it is formulated according to the preparation method in the conventional cosmetic field to combine as described in Table 6 below.

Ingredient Content (% by weight) Caprylic / Capric Glyceride 0.3 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water To 100

 Formulation Example 2 Preparation of Nourishing Lotion (Milk Lotion)

To prepare a nourishing lotion containing caprylic / capric glycerides of the present invention, it is formulated according to the preparation method in the conventional cosmetic field to combine as described in Table 7 below.

Ingredient Content (% by weight) Caprylic / Capric Glyceride 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Xanthan Gum 0.3 Incense, preservative a very small amount Purified water To 100

Formulation Example 3 Preparation of Nutritional Cream

To prepare a nutritive cream containing caprylic / capric glyceride of the present invention, it is combined as described in Table 8 and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Content (% by weight) Caprylic / Capric Glyceride 0.5 vaseline 7.0 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Squalane 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Xanthan Gum 0.5 Tocophenyl Acetate 0.1 Incense, preservative a very small amount Purified water To 100

Formulation Example 4 Preparation of Massage Cream

To prepare a massage cream containing the caprylic / capric glyceride of the present invention, it is combined as described in Table 9 and prepared according to the manufacturing method in the conventional cosmetic field.

Ingredient Parts by weight (%) Caprylic / Capric Glyceride 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocophenyl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Xanthan Gum 0.5 Incense, preservative a very small amount Purified water To 100

Formulation Example 5 Pack Preparation

To prepare a pack containing caprylic / capric glycerides of the present invention, it is formulated according to the preparation method in the conventional cosmetic field, as formulated in Table 10 below.

Ingredient Content (% by weight) Caprylic / Capric Glyceride 0.3 Propylene glycol 2.0 glycerin 4.0 Polyvinyl alcohol 10.0 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Incense, preservative a very small amount Purified water To 100

The present invention relates to a cosmetic composition for improving acne, which contains caprylic / capric glyceride as an active ingredient, significantly lowering the growth of propionibacterium acnes, a cause of acne, and having almost no skin irritation. It is possible to provide a cosmetic composition for improving acne that is excellent in safety and effective to the human body.

Claims (5)

Cosmetic composition for acne improvement containing caprylic / capric glycerides. According to claim 1, wherein the composition is a cosmetic composition for improving acne, characterized in that to inhibit the growth of acne bacteria. The cosmetic composition for improving acne according to claim 2, wherein the acne bacterium is Propionibacterium acnes. The cosmetic composition for improving acne according to claim 1, wherein the caprylic / capric glyceride contains 0.01 to 20.0 wt% based on the total weight of the composition. According to claim 1, wherein the composition is composed of softening cream, converging cream, nourishing cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, solid soap, liquid soap, powder, essence, pack Acne improvement cosmetic composition, characterized in that it has a formulation selected from.