KR20040098013A - Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체 - Google Patents

Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체 Download PDF

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Publication number
KR20040098013A
KR20040098013A KR10-2004-7014206A KR20047014206A KR20040098013A KR 20040098013 A KR20040098013 A KR 20040098013A KR 20047014206 A KR20047014206 A KR 20047014206A KR 20040098013 A KR20040098013 A KR 20040098013A
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KR
South Korea
Prior art keywords
heteroaryl
aryl
alkyl
heterocyclyl
arylalkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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KR10-2004-7014206A
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English (en)
Korean (ko)
Inventor
엘리 엠. 월리스
조세프 피. 리씨카토스
브라이언 티. 헐리
앨리슨 엘. 마를로우
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어레이 바이오파마 인크.
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Application filed by 어레이 바이오파마 인크. filed Critical 어레이 바이오파마 인크.
Publication of KR20040098013A publication Critical patent/KR20040098013A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-2004-7014206A 2002-03-13 2003-03-13 Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체 Withdrawn KR20040098013A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36416402P 2002-03-13 2002-03-13
US60/364,164 2002-03-13
PCT/US2003/007565 WO2003077855A2 (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Publications (1)

Publication Number Publication Date
KR20040098013A true KR20040098013A (ko) 2004-11-18

Family

ID=28041882

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2004-7014206A Withdrawn KR20040098013A (ko) 2002-03-13 2003-03-13 Ｍｅｋ 억제제로서의 ｎ3 알킬화된 벤즈이미다졸 유도체

Country Status (18)

Country Link
US (2) US20030216460A1 (enExample)
EP (1) EP1482944A4 (enExample)
JP (1) JP2005526076A (enExample)
KR (1) KR20040098013A (enExample)
CN (1) CN1652792A (enExample)
AR (1) AR038972A1 (enExample)
AU (1) AU2003220202A1 (enExample)
CA (1) CA2478534A1 (enExample)
CO (1) CO5611145A2 (enExample)
DO (1) DOP2003000614A (enExample)
IL (1) IL163996A0 (enExample)
MX (1) MXPA04008894A (enExample)
PA (1) PA8569201A1 (enExample)
PL (1) PL378635A1 (enExample)
RU (1) RU2300528C2 (enExample)
TW (1) TW200406203A (enExample)
UA (1) UA76837C2 (enExample)
WO (1) WO2003077855A2 (enExample)

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Also Published As

Publication number Publication date
UA76837C2 (uk) 2006-09-15
PL378635A1 (pl) 2006-05-15
AR038972A1 (es) 2005-02-02
DOP2003000614A (es) 2009-09-30
MXPA04008894A (es) 2005-06-20
PA8569201A1 (es) 2004-05-21
IL163996A0 (en) 2005-12-18
TW200406203A (en) 2004-05-01
JP2005526076A (ja) 2005-09-02
WO2003077855A2 (en) 2003-09-25
WO2003077855A3 (en) 2004-03-04
US20030216460A1 (en) 2003-11-20
CN1652792A (zh) 2005-08-10
CO5611145A2 (es) 2006-02-28
US20060106225A1 (en) 2006-05-18
CA2478534A1 (en) 2003-09-25
AU2003220202A1 (en) 2003-09-29
RU2004127925A (ru) 2005-05-27
EP1482944A4 (en) 2006-04-19
RU2300528C2 (ru) 2007-06-10
EP1482944A2 (en) 2004-12-08

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Patent event date: 20040910

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Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid