KR20040096468A - Method for preparing fermented soybeans containing selenium and germanium to improve health of human - Google Patents

Abstract

PURPOSE: A method for preparing fermented soybeans containing selenium and germanium is provided, which fermented soybeans have no toxicity, and a large quantity of organic selenium and germanium, so that the fermented soybeans can be useful for improving health of human. CONSTITUTION: The method for preparing fermented soybeans containing selenium and germanium comprises the steps of: (1) preparing germanium and selenium containing vegetables; (2) washing, cutting, freeze-drying and pulverizing the germanium and selenium containing vegetables; (3) selecting, washing and cooking soybeans, and sterilizing a vessel; (4) inoculating Bacillus subtilis to the boiled soybeans, fermenting the soybeans at 20 to 50 deg. C for 10 hours, cooling the fermented soybeans at 0 to 4 deg. C, hot wind drying or freeze-drying the fermented soybeans; and (5) mixing the dried fermented soybeans with the pulverized germanium and selenium containing vegetables of step (2).

Description

Manufacturing method of Cheonggukjang containing selenium and germanium {omitted}

The present invention relates to a manufacturing method of Cheonggukjang containing germanium and selenium,

The germanium-selenium-containing Cheonggukjang prepared according to the present invention contains a large amount of organic germanium and selenium, which are not toxic to the human body and have a high absorption rate. Improving heart and lung function, decomposing waste products, preventing cirrhosis of the liver, improving immune function, improving sexual function, treating muscle nutrition, and preventing cancer.

Recently, efforts have been made to increase nutritional added value by adding desired nutrients, elements or substances to existing agricultural products. A typical example of this is supplying organic or inorganic germanium and selenium as fertilizer to plants, and then organically processing through the plants, and then concentrating on the plants to obtain the effective concentrations of germanium and selenium, which are known components of the human body. There are also attempts to accumulate certain useful ingredients in livestock products such as meat and oil.

Germanium is one of the carbon group elements belonging to group 4B of the periodic table. It is known as the elemental symbol Ge, atomic number 32, and oxygen for which the atomic weight is 72.59%.

High-purity organic germanium completely escapes from the human body through urine without holding and accumulating cancer cells, toxins, contaminants, and heavy metals in the human body within about 20-30 hours after taking various tasks in the human body after taking them. It is very safe because there is no toxicity at all.

Source: Asai Germanium Research Institute, Tokyo, Japan.

On the 28th and 6th month of the animal experiment, 1mg / kg / Day was administered and there was no specific toxicity or poisoning phenomenon except for the slight weight loss of the male at the end of the 6th month. In addition, because germanium is excreted in the urine as it is taken, there were no symptoms of accumulation or poisoning in any organ after 6 months of testing.

Source: Journal de Toxicologie Clinique et Experimental Dec. 11, 1991 (7-8) 421-36-

Organo germanium (Ge-132) prevents injury to cells

Animal studies of the effects of germanium (Ge-132) on injured (injury) cells have found that the treatment of the cells of germanium (Ge-132) -treated animals prevents and injuries themselves. All these effects are related to the role of germanium (Ge-132). These results show that germanium (Ge-132) promotes smooth metabolism of cells, which is protected from injury.

Source: Yao Hsueh Hsueh Pao Acta Pharmaceutica Sinica, 1992, 27 (7): 481-5

Germanium as an Individual to Alleviate Chronic Fatigue (Ge-132)

It has been found that germanium weakens and alleviates the serious injury of the Chronic Epstein-Barr Virus Syndrome. Millions of Americans, as well as many people around the world, suffer from this chronic Epstein-Barr Virus Syndrome.

Source: Use of Organic Germanium in Chronic Epstein-Barr Virus Syndrome, 'Journal of Orthomolecular Medicine, 1989

Germanium slows the development of cataracts, Ge-132 slows the development of cataracts, and has been shown to be effective in the prevention and treatment of cataracts.

Source: Department of Biological Sciences, Oakland University, Rochester, MI, Experimental Eye Research, August 1995. '

Germanium as an inhibitor of mutagenic factor

Many studies and papers recommend a balanced diet of several essential nutrients. In particular, nutrients such as antioxidants, vitamins and selenium are potential and definitive carcinogen inhibitors. Furthermore, constant doses of germanium have been shown to inhibit mutagenic factors.

Source: Department of Oral Biology, Indiana University School of Dentistry, Indianapolis 46202.Mutation Research 1995 Aug., 335 (1): 21-6

Germanium improves postoperative recovery and immunity

Germanium has been shown to be effective as an interferon derivative and to enhance immunological response to rejection of post-operative phagocytes, leukocyte chromatin, lymphocytes around blood, and their control groups. Such effects of germanium persisted for a long time after surgery, and these results suggest that germanium is effective as a prophylactic and therapeutic agent for several clinical symptoms of postoperative immune rejection in animals. It is shown.

Source: Journal of Veterinary Medical Science, 1993 Oct., 55 (5): 795-9.

Effect of Germanium on Cancer and Malignant Tumors

Many research papers and clinical reports from the 16th and 19th centuries have mentioned that metals and metal compounds are useful in the treatment of cancer and leukemia. Unfortunately, the fact that malignant tumors, cancers, etc. can be conquered by inorganic and metal compounds, that is, such studies were forgotten by people until 1960.

Many metal compounds, including germanium, have shown great effects as anticancer and malignant tumor removers in animal and human clinical trials. Source: European Journal of Clinical Pharmacology, 1994, 47 ( 1): 1-16

In animal experiments, organic germanium has a lot to do with blood pressure-lowering effects, and the results of these studies on the lowering of blood pressure in organic germanium can be found in page 112 of the 38th annual meeting of the Japan Cancer Society in 1979. Source: The Clinical Report (Kiso to Rinsho, in Japanese) 7 (1978): 719

Organic germanium has been considered to restore the immune system to its original state in older mice that have lost their immune response.

Source: International Archives of Allergy 63 (1980): 338-339

Germanium has been shown to be a potent potent inhibitor of mutagenesis in Salmonella cocci, and its effects on bacteria have been noted. Source: Mutation Research 125 (1984): 145-151

Organic germanium has been shown to reduce osteoporosis as well as bone fracture in osteoporosis patients.

Source: Asai Germanium Research Institute, Tokyo, Japan, 1984.

Oral administration of germanium has the positive effect that the interferon inducer is regulated in the body.

Source: Microbiology and Immunology 29, 1985: 65-74.

Germanium oxide (organic germanium) has been shown to act as an important interferon derivative in the human body. Source: Proceedings of the Japan Cancer Association II, Annual Meeting, 1979, Page 193.

Organic germanium has been shown to inhibit tumors, malignant tumors.

Source: Cancer and Chemotherapy 6, in Japanese, (1968): 79-83.

Oral administration of organic germanium has been observed to significantly prolong life. Source: Gan To Kagaku Ryoho 12, December 1985: 2345-51.

The fact that organic germanium is a potent tumor and malignant tumor suppressor has been shown to be related to the function of organic germanium as an interferon derivative.

Source: Tohoku Journal of Experimental Medicine 146, May 1985: 97

In animal experiments on tumor suppression, tumors stopped growing in animals administered with organic germanium and the tumors soon contracted.

Source: Anticancer Research 6, March-April 1986: 177-82.

Animal experiments on the therapeutic effects of organic germanium have been shown to prevent tumor growth. These phenomena appear to be the result of the active activity of the phagocytic cells in the body. (The phagocytic cells are also an immune system, they attack the enemy)

Source: Gan To Kagaku Ryoho 12 November 1985: 2122-8.

We have studied the results of organic germanium when used with chemotherapy, an anticancer drug, as a tumor suppressor. The results showed that tumor growth stopped, tumor metastasis was inhibited, life span was prolonged, the side effects of chemotherapy were reduced, and the weight lost to chemotherapy was restored.

Source: Gan To Kagaku Ryoho 13, Aug. 1986: 2588-93.

Animals inoculated with cancer tumors and leukemia cells were treated with organic germanium. In this study, organic germanium has been shown to be effective in improving the body's defenses rather than directly attacking cancer cells. In other words, the immune system including phagocytic cells and T-cells seems to work. Source: Anticancer Research 5, Sep.-Oct. 1985: 479-83

In animal experiments against blood pressure changes, normal blood pressure was not changed as observed after administration of germanium to animals with normal blood pressure. However, after the administration of animals with high blood pressure, the blood pressure was surprisingly returned to normal 7-10 days after Germanium administration. This effect persisted for quite some time after stopping the administration of germanium.

Source: Japan Experimental Research Institute, Tokyo, Japan.

Organic germanium has shown the same strong analgesic effect as morphine in oral and injection. Taking or administering germanium has been shown to increase the production of endorphins in the body and to increase the analgesic effects of each organ of the body.

Source: Journal of Pharmacological Dynamics 6 (1983): 814-820.

High-purity organic germanium completely escapes from the human body through urine without holding and accumulating cancer cells, toxins, contaminants, and heavy metals in the human body within about 20-30 hours after taking various tasks in the human body after taking them. It is very safe because there is no toxicity at all.

Source: Asai Germanium Research Institute, Tokyo, Japan.

Elements of miracles, wizards of blue light .. In developed countries such as the United States, selenium is called. It is said to be effective for anti-aging, cancer prevention, and immune function activation.

In the early period when the element symbol was Se, it was a toxic element, so it existed as a long forgotten element because it could not find a suitable use. The oldest record of toxicity can be found in the 13th-century Marco Polo's Eastern Gate, and in 1860, a military surgeon in South Dakota reported horses showing selenium poisoning. Excessive intake of selenium caused fatal symptoms of hair and hoof fall out. However, since the 1960s, research on deficiency has become active and has attracted interest. In 1973, selenium was found to be an essential component of glutathione peroxidase, an enzyme that acts as an antioxidant in animals. Later, in 1978, the World Health Organization (WHO) recognized selenium as an essential nutrient and set 50 to 200 µg as the recommended daily dose. Selenium fever blowing in developed countries is showing signs of landing in Korea. Cheonggukjang-chicken and other products with enhanced selenium content are appearing one after another, and pharmaceutical companies are rushing to add selenium to multivitamins. In recent years, selenium deficiency has been identified as a cause of SARS, and interest in selenium has increased significantly around the world.

The present inventors used the powder of fruits and plants produced by the application number: 10-2003-0089903, 10-2004-0042371, in particular, germanium is a compound containing all germanium germanium- yeast complex, Ge132, chelated organic Germanium can be used, and in the case of selenium, soybeans boiled or boiled by diluting selenium-containing substances such as inorganic selenium and selenium-yeast complex such as Na2SeO3, Na2SeO4 and chelated organic selenium to an appropriate concentration in water Inoculate selenium at a suitable concentration in the soybean with Bacillous in the concentration necessary for the human body to produce a cheongukjang containing selenium, but in the present invention as a method of cultivating plants containing selenium and germanium (10-2003-0089903, 10 2004-0042371) Lyophilized plants containing raw edible germanium and selenium grown in the filed method are lyophilized and then ground, aged, dried, The printed stirring of soybean powder and at least 1% hapcheom, advantageously highly all nutrition and absorption in the body of a living vegetable and completed the present invention succeeded in producing a soybean containing a safe organic germanium and selenium good body availability.

Therefore, an object of the present invention is to prepare a cheonggukjang containing germanium and selenium separately or containing germanium and selenium at the same time, selenium, germanium-containing Cheonggukjang containing selenium, germanium containing ingredients and grown in vegetables and fruits It is added to the green juice and juice of plants produced by the method of cultivating plants containing a selenium and germanium (fermented to: 10-2003-0089903, 10-2004-0042371) or fermented with dried powder and Bacillous Subtilis strains. Therefore, it is to provide powders of Cheonggukjang and Cheonggukjang, which contain safe germanium and selenium, which have high absorption rate in the body and are good for human use, or contain germanium and selenium at the same time.

In order to complete the above invention, the present inventors used powders of fruits and plants produced by the inventors of the patent application No. 10-2003-0089903, 10-2004-0042371 filed by the inventors, in particular, germanium is a compound containing all germanium Germanium-yeast complex, Ge132, chelated organic germanium, etc. can be used.In case of selenium, selenium-containing substances such as Na2SeO3, Na2SeO4 and selenium- yeast complex, chelated organic selenium, etc. Diluted with boiled beans or inoculated with boiled soybeans with Bacillous Subtilis in proper concentrations in Brazil boiled soybeans or selenium at a proper concentration to produce boiled soybeans containing selenium, but in the present invention selenium, germanium As a cultivation method of plants containing this (10-2003-0089903, 10-2004-0042371) A plant containing germanium and selenium is lyophilized and pulverized, and mixed and stirred with the powder of aged, dried and pulverized Cheonggukjang at least 1%. Successful production of Cheonggukjang containing safe organic germanium and selenium completed the present invention.

Method for producing the germanium and selenium-containing Chungkookjang according to the present invention,

(1) cultivating plants containing 0.01 mg / kg of selenium and 0.01 mg / kg or more of germanium according to the method of Application Nos. 10-2003-0089903 and 10-2004-0042371;

(2) washing, cutting, lyophilizing and powdering the grown plants;

(3) screening, ripening the beans, boiling the beans and sterilizing

(4) inoculating boiled soybeans with Bacillous Subtilis or all Bacillous or natto bacteria used in connection with fermentation of Cheonggukjang, fermenting at 20 ~ 50 ℃ for 10 hours or more at 0 ~ 4 ℃ After aging and hot air lyophilized with 10% or less moisture, it is mixed with powder of raw edible plant containing selenium and germanium to contain selenium, germanium and selenium and germanium simultaneously. And it consists of the step of preparing the powder of Chungkookjang.

Hereinafter, although an Example demonstrates this invention, the scope of the present invention is not restrict | limited by these.

Hereinafter, the present invention cultivated according to the embodiment will be described in detail.

Example 1:

Applied number: 10-2003-0089903 Method of washing, cutting and freeze-drying containing 3mg / kg of selenium in buttercup to obtain powder of buttercup containing 3000µg of selenium in dry weight of 50g, then aged and dried Was obtained by stirring with 95% of powder and 5% of buttercup powder having a concentration of selenium of 3 mg / kg, to obtain 200 g of Cheonggukjang powder containing 600 μg of selenium.

Example 2:

0.5mg / kg germanium in the buttercups, washed, cut and lyophilized to obtain powder of buttercups containing 500µg germanium in dry weight of 50g according to the method of Application No. 10-2004-0042371 Was stirred with 95% of the powder of powder and 5% of the buttercup powder having a germanium concentration of 0.5 mg / kg, to obtain 200 g of Cheonggukjang powder containing 100 µg of germanium.

Example 3:

Applied No. 10-2003-0089903 and Applied Nos. 10-2004-0042371, the buttercup contains 0.5 mg / kg germanium and 3 mg / kg selenium, which is washed, cut and lyophilized. Obtain powder of buttercups containing both germanium and 3000 μg selenium at the same time, and then agitate with 95% of aged and dried Cheonggukjang powder and 5% buttercup powder with a concentration of 0.5mg / kg germanium. 200 g of Chungkookjang powder containing µg of selenium at the same time was obtained.

Until the present invention, in order to ingest the components of selenium and germanium, each had to be ingested separately, but the cheonggukjang prepared in accordance with the present invention by ingesting the ingredients of selenium and germanium separately or at the same time to produce the anti-cancer antioxidant effect By mixing germanium and selenium with the invented plants, it is possible to naturally ingest germanium and selenium which is beneficial to the human body, which is nontoxic and has a high absorption rate, which is therapeutic and preventive.

Claims (5)

The method of claim 1, wherein all compounds containing germanium, germanium-yeast complex, Ge132, and chelated organic germanium-containing materials are added to boiled water or soybeans and stirred and matured together with Cheonggukjang. According to claim 2, in the case of selenium, the material containing inorganic selenium, selenium-yeast complex, chelated organic selenium, such as Na2SeO3, Na2SeO4, is added to the boiled water or soybeans and stirred to mature with Cheonggukjang Manufacturing method of Cheonggukjang The selenium-containing plants, leafy vegetables, (lettuce, buttercups, cabbage, skipping, sprouts, celery, green onions, chicory, chard, leek, bok choy, cabbage, kale, leaf beet, chicory, mugwort, mustard, etc.) Fruits (pears, apples, raspberries, grapes, citrus fruits, sweet potatoes, radish, beets, carrots, onions, garlic, etc.) and vegetables (watermelon, melon, strawberries, melons, tomatoes, peppers, pumpkins, cucumbers, etc.) Manufacturing method of Cheonggukjang using powder and raw vegetables of selenium-containing plants such as kiwi, plum, etc.) special crops, tea plants (mushroom, ginseng, deodeok, bellflower, green tea tree, hemp, brazil nut, etc.) Germanium-containing plants, leafy vegetables (lettuce, buttercups, cabbage, skipping, sprouts, celery, green onions, chicory, chard, leek, bok choy, cabbage, kale, leaf beet, chicory, mugwort, mustard, etc.) Fruits (pears, apples, raspberries, grapes, citrus fruits, potatoes, melons, strawberries, melons, tomatoes, peppers, pumpkins, cucumbers, etc.) Manufacturing method of Cheonggukjang using powder and raw vegetables of germanium-containing plants such as kiwi, plum, etc.) special crops, tea plants (mushroom, ginseng, deodeok, bellflower, green tea tree, hemp, etc.) The method of claim 5, which is prepared by adding fermentation enzymes of leafy vegetables, fruits, fruits and vegetables, and special crops containing selenium and germanium at the same time.