KR20040062744A - Cosmetic Composition Comprising Sophorae Flos Extract and Arbutin for Skin Whitening - Google Patents

Abstract

PURPOSE: Provided is a whitening cosmetic composition containing an extract of Sophorae Flos and arbutin which involves excellent whitening and very low skin stimulation, and enhances the whitening efficacy with the co-use of the two contents. CONSTITUTION: The whitening cosmetic composition comprises 4-6wt.% of a Sophorae Flos extract, and 0.8-1.2wt.% of arbutin. The cosmetic composition is made in the form of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant-containing cleanser, an oil, a powder foundation, a wax foundation, or a spray.

Description

Cosmetic composition comprising lump extract and arbutin {Cosmetic Composition Comprising Sophorae Flos Extract and Arbutin for Skin Whitening}

The present invention relates to a whitening cosmetic composition, and more particularly to a whitening cosmetic composition comprising a lump extract and arbutin as an active ingredient.

In general, human skin color is determined by a quinone complex called melanin which is synthesized by melanin forming cells present in the basal cell layer of the epidermis. The unit forming melanin is Tyrosine, an amino acid, which is converted into DOPA by Tyrosinase, oxidized, and then converted into Dopaquinone. The synthesized melanin is collected in a cell organelle called melanosome and transferred to keratinocytes through dendritic processes.

Numerous factors influence melanin production, and the ultraviolet rays irradiated to the skin play the most important role in melanin formation. The mechanism of action that can protect the skin from ultraviolet rays can be divided into three stages. The first step is to apply UV-blocking or absorbing material to the skin by blocking the UV rays to prevent UV penetration ( Fragrance J. 3: 56-61 (1996)). By removing the free radicals, the change of biomaterials (DNA, proteins, lipids, etc.) by free radicals is prevented. The third step is to restore the alteration of biological material changed by the attack of free radicals generated by ultraviolet rays and to restore the degradation of physiological function of skin cells by ultraviolet rays ( J. Invest. Dermatol. , 91: 158-161 (1998). )). Substances protecting the skin from ultraviolet light have a whitening effect for this reason.

There is a big market in Korea and Japan for cosmetics that have skin whitening effects. In addition, the market is increasing in Korea due to the functional cosmetics law.

The mechanism of whitening is already well known in many patents and papers. In general, it is a method that fundamentally prevents the activation of tyrosinase by blocking UV rays, and inhibits the already activated enzyme tyrosinase (which induces melanin synthesis) and a signal that promotes melanin production from inflammatory cells. Methods due to transporter inhibition are known.

Typical whitening ingredients include Arbutin contained in alpine plants, such as bilberry leaves, and those extracted from cultures of spawns made from miso and liquor, which are found in the hands of people who touch rice bran. Kojic acid, a whitening ingredient stabilized with vitamin C, and a placenta extract extracted from bovine and sheep placenta, containing various enzymes, vitamins and amino acids, and placenta that protects skin in addition to the whitening effect, Early stages of melanogenesis by inhibiting endothelin, an ingredient originally developed by Gao, extracted from Rucinol, a chamomile that exerts a block-like effect when inhibiting tyrosinase activity. Camoilla extracts, which are whitening ingredients inhibited by, are known.

In addition, four kinds of raw materials for functional cosmetics that help skin whitening in functional cosmetic standards and test methods under the provisions of Article 4, paragraph 1 of Cosmetics Act No. 2001-44 of the Korea Food and Drug Administration (KFDA) were notified. kazinoki) and powder obtained by extracting the middle or root of the same plant (Moraceae) from ethanol and ethyl acetate, or a 2 w / v% butylene glycol solution thereof. The tyrosinase inhibition rate of this material is 48.5-84.1%. Secondly, arbutin and ethyl ascorbyl ether are mentioned above and derivatives of vitamin C and finally oil soluble licorice (glycyrrhiza) extract.

However, the whitening agents developed to date have a weak whitening effect and have a problem of improving side effects such as skin irritation.

The present inventors have intensively researched to develop a whitening cosmetic having a very good whitening effect and low skin irritation compared to the conventional whitening cosmetics, and when using a mixture of lump extract and arbutin at a predetermined ratio, By confirming that the effect is achieved, the present invention has been completed.

Accordingly, it is an object of the present invention to provide a whitening cosmetic composition having improved efficacy.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

1 is a graph showing the whitening effect after 8 weeks after applying the whitening cosmetic composition of the present invention.

The present invention provides a whitening cosmetic composition comprising 4-6% by weight of Sophorae Flos extract and 0.8-1.2% by weight arbutin based on the total composition.

The inventors of the present invention, while conducting research on the whitening cosmetics, the supernatant extract (Korean Patent Application Publication No. 10-2001-0018657) and arthrotin inhibitor of tyrosinase activity excellent in UV absorption effect, free radical scavenging effect and cell activity promoting effect When the mixture is used in a constant weight ratio, it has been found that the whitening effect is much better than when used individually, or when used in other ratios.

The synergistic whitening effect of these two active ingredients is synergistic by two mechanisms, namely, two mechanisms, namely, inhibition of the formation of tyrosinase and inhibition of activity due to UV blocking, thereby showing excellent whitening effect. will be.

In general, cosmetic formulations should use chemicals with a high Sun Protection Faction (SPF) to block UV rays, which can cause skin irritation or allergic reactions such as allergies, limiting their use. This is followed ( Acta Derm. Venereol. , 66: 290-294 (1986)).

However, the present inventors have found that the monohydrate extract used in the present invention is excellent in the effect of UV protection but can be made safer cosmetics because it is a natural plant extract.

In the composition of the present invention, when the content of the lump extract is less than 4% by weight, the effect is insignificant, and when it exceeds 6% by weight, there is a problem of discoloration in the formulation. In addition, when arbutin is less than 0.8% by weight, there is a problem of low effect, and when it exceeds 1.2% by weight, there is a problem of skin irritation.

Therefore, since the content ratio of the lump extract and arbutin in the composition of the present invention has a critical meaning, it should be used within the above content ratio.

According to the most preferred embodiment of the present invention, the content of lump extract is 5% by weight, the content of arbutin is 1.0% by weight.

The lumped extract can be obtained using various extraction methods known in the art, preferably, (a) water, (b) anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, Butanol, etc.), (c) the mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform or (g) 1,3-butylene glycol. Can be. More preferably, extraction is carried out using an aqueous methanol and ethanol solution, and most preferably, extraction is performed using an ethanol aqueous solution.

On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can be obtained in addition to the above-described extraction solvent, as well as a lump extract having substantially the same effect using other extraction solvents.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the lump extract of the present invention.

The lumped extract of the present invention may be prepared in powder form by additional processes such as distillation under reduced pressure and freeze drying or spray drying.

Ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to lump extracts and arbutin as active ingredients, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.

The whitening composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing It may be formulated as cleansing, oil, powder foundation, emulsion foundation, wax foundation, spray, and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The whitening cosmetic composition of the present invention not only has a very good whitening effect, but also has a very low skin irritation, and in particular, is higher than when the lump extract or arbutin is used separately, or when the two components are used at different ratios. Whitening effect.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Example

In order to measure the whitening effect of the composition of the present invention comprising a lump extract and arbutin, Formula A, B, C, D and E were prepared as shown in Table 1 below. As shown in the characteristics of the prescription was prepared by changing the ratio of lump extract and arbutin.

ingredient A prescription B prescription C prescription D prescription E prescription F prescription glycerin 4.0 4.0 4.0 4.0 4.0 4.0 Butylene Glycol 2.0 2.0 2.0 2.0 2.0 2.0 Propylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 EDTA-2Na 0.02 0.02 0.02 0.02 0.02 0.02 Polysorbate 60 1.0 1.0 1.0 1.0 1.0 1.0 Glyceryl Stearate 1.5 1.5 1.5 1.5 1.5 1.5 Beeswax 4.0 4.0 4.0 4.0 4.0 4.0 Macadamia Nut Oil 5.0 5.0 5.0 5.0 5.0 5.0 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 antiseptic a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Spices a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Lump extract 5.0 5.0 - 1.0 8.0 - Arbutin 1.0 - 1.0 1.5 0.5 - Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount system 100 100 100 100 100 100

Test Example 1: Skin Primary Irritation Test

In order to determine the skin irritation of the products prepared according to the above embodiment, a certain amount (approximately 0.1 g) of each sample was patched for 5 hours on a 5 x 20 cm area in the lower part of both arms of 50 healthy adult men and women. After removal, the skin condition was visually read after 1 hour and 24 hours after removal, and the results are shown in Table 2. The criterion described in Table 2 is as follows, and the stimulus is calculated by the following equation:

* Criteria *

-: No erythema or unusual symptoms; +-: Slightly redder than the surroundings

+: Significantly reddening around

Prescription Number of test subjects Judgment result Stimulus% ++ + +-- A 50 - - 4 46 2.7 B 50 - - 2 48 1.3 C 50 - One 2 47 2.7 D 50 - One 3 46 3.3 E 50 - - 3 47 2.0 F 50 - - One 49 0.7

As can be seen from the skin irritation test results of the above table, it can be seen that the stimulation degree of the prescriptions shows the normal irritation degree compared to the general formulations. In particular, the addition of lump extracts showed little increase in stimulation (comparison of prescription A and prescription C).

Test Example 2: Measurement of Whitening Effect

The subjects were 30 Korean female volunteers aged 19-40. Particularly, the women with black skin among the women who applied were included. Minolta CR 300 was used as a measuring instrument, and the measurement was performed every two weeks for a period of two months. The measurement area was marked 7 cm by 1 cm on the arm and steadily applied to each of 6 different prescriptions and one was placed as a control value for comparison. The difference from the control is shown in FIG. 1. As can be seen in Figure 1, after 8 weeks ΔL value was confirmed that the prescription A has a 44-130% or more effect compared to other prescriptions and the control.

As described in detail above, the present invention provides a whitening cosmetic composition comprising a monohydrate extract and arbutin in a predetermined ratio. The whitening cosmetic composition of the present invention not only has a very good whitening effect, but also has a very low skin irritation, and in particular, is higher than when the lump extract or arbutin is used separately, or when the two components are used at different ratios. Whitening effect.

Claims (3)

A whitening cosmetic composition comprising 4-6% by weight of lump extract and 0.8-1.2% by weight arbutin based on the total composition. The whitening cosmetic composition according to claim 1, wherein the content of the lump extract is 5% by weight, and the content of arbutin is 1.0% by weight. The composition of claim 1 wherein the cosmetic composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Whitening cosmetic composition, characterized in that it has a formulation selected from the group.