KR20040062296A - Pharmaceutical composition for palpate secretion of growth hormone - Google Patents
Pharmaceutical composition for palpate secretion of growth hormone Download PDFInfo
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- KR20040062296A KR20040062296A KR1020030000099A KR20030000099A KR20040062296A KR 20040062296 A KR20040062296 A KR 20040062296A KR 1020030000099 A KR1020030000099 A KR 1020030000099A KR 20030000099 A KR20030000099 A KR 20030000099A KR 20040062296 A KR20040062296 A KR 20040062296A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/324—Foods, ingredients or supplements having a functional effect on health having an effect on the immune system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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Abstract
Description
본 발명은 성장호르몬 분비촉진용 생약제 조성물에 관한 것으로, 더욱 상세하게는 홍화씨, 맥아, 녹각, 복분자, 토사자, 석창포, 백복령 및 산사자를 포함하는 성장호르몬분비 촉진 또는 면역력 강화용 생약제 조성물에 관한 것이다.The present invention relates to a herbal composition for promoting growth hormone secretion, and more particularly, to a herbal composition for promoting growth hormone secretion or enhancing immunity, including safflower seed, malt, green tea, bokbunja, earth and sand, Seokchangpo, Paekbokryeong, and hawthorn.
일반적으로, 최근 경제성장에 따른 생활 수준의 향상과 영양개선, 유년기의 생활 환경 개선 등으로 인해 소아의 평균신장이 점차 증가되고 있다. 또한 매스미디어를 통한 큰 신장을 선호하는 사회적 분위기의 형성으로 신장이 작은 소아의 열등감이 가중되고 있다. 이렇게 평균 신장이 늘어남에 따라 대부분의 사람들이 성장에 많은 관심을 갖게 되었다.(1. 박선영, 이동환 외 8명, 진생성장원이 성장기흰쥐의 장골 길이성장에 미치는 영향, 한국본초의학회지, 4(2), 124~133(2001).)In general, children's average height is gradually increasing due to recent economic growth, improved living standards, improved nutrition, and improved childhood living conditions. In addition, the formation of a social atmosphere that favors large kidneys through mass media is increasing the inferior feelings of small children. As the average height increased, most people became interested in growth. (1. Park Sun-young, Lee Dong-hwan and 8 others, the effect of Ginseng Growth Source on the long bone growth of growth rats, Korean Journal of Herbal Medicine, 4 (2 , 124-133 (2001).)
신체성장은 세포수가 증가하고 세포의 크기가 커지면서 신체의 크기가 증가하는 것으로, 몸을 구성하는 성분인 단백질이 증가를 수반하고 골격과 근육이 커지며 이들의 기능도 강화된다. 이와 같은 성장은 호르몬의 작용에 의해서 이루어지는것으로 성장호르몬은 왕성한 성장을 보이는 성장기의 어린이가 가장 분비량이 많으며, 성장기 이후에는 호르몬의 분비량이 급격하게 감소한다. 따라서 20대 이후부터는 호르몬 분비량은 급격하게 낮아지고 60대에는 20대에서의 분비량의 25% 이하로 감소하게 된다. 이러한 나이에 따른 성장호르몬의 감소는 노화와 직접적으로 관계가 있으며, 그 원인은 성장호르몬의 결핍 때문이라고 여겨진다.(2. 최철석, 김재수 외 3명, 식물추출물[YGF]의 IGF-1 분비 촉진에 미치는 영향, 17(2), 203-206(2002))Body growth is the increase in the number of cells and the size of the body increases as the size of the cell increases, accompanied by an increase in the protein constituting the body, the skeleton and muscles are increased, and their function is also strengthened. This growth is caused by the action of hormones, growth hormone is the most secreted growth of children in the growth phase, the hormone secretion is rapidly reduced after the growth phase. Therefore, after 20s, hormone secretion is drastically lowered, and in the 60s, the amount of hormone secretion is reduced to 25% or less. This age-related decrease in growth hormone is directly related to aging and may be attributed to the lack of growth hormone. (2. Chul-Seok Choi, Jae-Soo Kim and three others, to promote IGF-1 secretion of plant extract [YGF]) Impact, 17 (2), 203-206 (2002))
일반적으로 사람과 동물의 뇌하수체 전엽(Anterior Pituitary)에서 분비되는 단백질성 호르몬인 성장호르몬은 인간의 경우 191개의 아미노산으로 구성되어 있으며, 소마토트로핀(Somatotropin)이라고도 한다. 이는 몸의 성장발육을 촉진시키고 당질, 지방질, 단백질의 신진대사에 직접 작용하여 골격성장은 물론 내장 등의 성장 속도를 조절하는 각종 작용을 나타낸다. 그리고, 혈액 중 성장호르몬의 농도는 수면이나 스트레스 등과 같은 자극에 의해 수분 내에 급격히 상승하기도 한다. 성장호르몬은 간, 말초조직에서 인슐린 유사 성장인자(Insulin-like growth factor-1, IGF-1)를 생성하게 한다.Growth hormone, a proteinaceous hormone secreted by the anterior pituitary of humans and animals, is composed of 191 amino acids in humans, also called somatotropin. This promotes the growth and development of the body and directly acts on the metabolism of sugars, fats, and proteins, and shows various effects of regulating the growth rate of the intestines, as well as skeletal growth. In addition, the concentration of growth hormone in the blood may rise rapidly within minutes due to stimulation such as sleep or stress. Growth hormone causes the production of insulin-like growth factor-1 (IGF-1) in liver and peripheral tissues.
성장호르몬에 의해 조절되는 인슐린 유사 성장인자의 가장 중요한 생체내 역할은 신생아 성장과 발달에 관여하는 것이다. 연골세포에서 콜라겐의 합성을 촉진하여 뼈를 성장시키며, 대사작용을 통해서 단백질 합성작용을 증가시킴으로써 근육을 증가시키고 동시에 지방조직으로부터 지방산의 산화를 증가시켜 체지방을 감소시키는 기능이 있다. 이는 출생 후, 점차 증가하여, 사춘기 동안 급격히 증가한후, 성인에는 200 ng/ml로 유지되다가 노령에서는 감소하여 거의 0이 된다. 이와 같은 연구결과로부터, 일반적으로 IGF-1의 수치는 나이가 들면서 감소한다는 것을 알 수 있으며, IGF-1이 증가한다는 것은 성장호르몬의 수치가 체내에서 증가되고 있다는 것을 보여준다고 할 수 있다.The most important in vivo role of insulin-like growth factors regulated by growth hormone is to be involved in neonatal growth and development. In cartilage cells to promote the synthesis of collagen to grow bones, metabolism increases protein synthesis by increasing the muscles and at the same time has the function of reducing body fat by increasing the oxidation of fatty acids from adipose tissue. It increases gradually after birth, increases rapidly during puberty, then remains at 200 ng / ml in adults and decreases to near zero in old age. From these findings, IGF-1 levels generally decrease with age, and increasing IGF-1 indicates that growth hormone levels are increasing in the body.
사춘기 시절의 급성장은 성장호르몬 및 성호르몬의 분비가 증가되어 나타난다. 성장호르몬은 장골의 성장을 돕고 성호르몬은 척골의 성장을 도와주며 성장호르몬 분비에도 영향을 주기 때문에 급성장이 이루어진다고 알려져 있으며, 성장호르몬(Growth hormone)의 분비는 시상하부의 성장호르몬 방출호르몬(Growth Hormone Releasing Hormon, GHRH)에 의해 자극되며 성장호르몬 분비 억제호르몬(소마토스타틴;Somatostatin(SS))에 의해 억제된다. 또한, 지금까지 알려진 성장호르몬의 분비를 자극하거나 억제시키는 물질은 대부분 시상하부에 작용하여 GHRH와 SS의 분비를 조절하여 간접적으로 성장호르몬의 분비상태를 조절하는 것으로 알려져 있다.The rapid growth during puberty is accompanied by increased secretion of growth hormones and sex hormones. Growth hormone helps the growth of long bones, sex hormone helps the growth of the ulna, and growth hormone secretion is known to be a rapid growth, growth hormone secretion of the growth hormone (Growth hormone) growth hormone release hormone (Growth of the hypothalamus) Hormone Releasing Hormon (GHRH) and is inhibited by growth hormone secretion inhibitor hormone (somatostatin (Somatostatin (SS))). In addition, substances that stimulate or inhibit the secretion of growth hormone known to date are mostly known to act on the hypothalamus to indirectly regulate the secretion of growth hormone by controlling the secretion of GHRH and SS.
사람의 성장을 살펴볼 때, 대개 유전적인 영향이 가장 크게 영향을 미치는 것으로 생각되고 있으나, 실제는 23% 정도 밖에 해당되지 않는다. 나머지 77%가 후천적 영향에 의해 결정되며, 영양이 31%, 운동 20%, 환경이 16%, 기타 10% 정도라는 연구결과가 발표된 적이 있다(참조, 가와하다 아이요시, '키가 크는 비결', 제일미디어, 개정판 1쇄 1997. 6. 9 인쇄, 1997. 6. 13 발행).When looking at human growth, genetic influence is usually thought to have the greatest impact, but in reality it is only about 23%. The remaining 77% is determined by acquired effects, and research has shown that nutrition is 31%, exercise 20%, environment 16%, and other 10% (cf. Kawada Aiyoshi, Cheil Media, Revision 1, June 9, 1997, June 13, 1997).
현재까지 개발된 성장장애 치료법에는 성장호르몬제제 투여와 일리자노프수술 및 건강보조식품복용 등이 있다. 1958년 부터 성장호르몬 결핍증 환자에게 성장호르몬을 투여하기 시작하였으며, 성장호르몬이 유전공학의 발달에 의해 대량생산이 가능해짐에 따라 성장호르몬결핍증 뿐만 아니라 터너증후군, 가족성 왜소증 같은 성장호르몬 비결핍성 왜소증에 성장호르몬 제제를 투여하기도 한다. 그러나, 성장호르몬 제제는 성장호르몬이 부족한 사람의 경우에는 뛰어난 효과를 보이나, 호르몬 분비가 정상인 대다수의 사람에게 오용될 때는 말단비대증, 갑상선 기능 저하증, 성장호르몬 항체형성 등의 부작용을 가지고 있으며, 대량 투여 시에는 당내불성(glucose intolerance)이 나타나기도 하므로 남용을 방지할 필요가 있다.Treatments for growth disorders developed to date include growth hormone preparations, irizanov surgery and dietary supplements. Since 1958, growth hormone has been administered to patients with growth hormone deficiency, and as growth hormone becomes mass-produced by the development of genetic engineering, growth hormone nondeficient dwarfism such as Turner syndrome, familial dwarfism, as well as growth hormone deficiency Growth hormone preparations may also be administered. However, growth hormone preparations have excellent effects in those who lack growth hormone, but when they are misused by most people with normal hormone secretion, they have side effects such as acromegaly, hypothyroidism, and growth hormone antibody formation. In the city, glucose intolerance is also present, so it is necessary to prevent abuse.
그리고, 일리자노프 수술은 키를 키울 수 있는 방법으로 알려져 있으나 이 수술은 단순히 작은 키를 크게 하는 수술이 아니고, 사고로 인한 다리부상으로 성장기에 성장판이 손상되어 양측하지 길이가 비대칭으로 성장되어서 정상적으로 보행할 수 없는 사람들에게 권해주는 시술법이다. 또한 선천적 기형으로 한쪽 다리가 기형적으로 짧은 사람들에게 조금이라도 정상생활을 할 수 있도록 도움을 주는 것이 목적으로 이 수술을 받으면 짧은 쪽의 다리뼈를 늘려 보행하는데 많은 도움을 받게 된다. 그러나, 일반적인 키가 작은 사람에게 양쪽다리를 억지로 늘린다면 환자의 고통, 사회적 비용손실을 감수하더라도 예상치 못한 부작용으로 인해 정상보행을 하지 못할 수도 있다.In addition, Ilizanov surgery is known as a way to increase the height, but this surgery is not just a surgery to increase the height of the small, but due to an accidental injury to the growth plate due to leg injuries, both sides of the lower limbs grow asymmetrically It is recommended to people who can not walk. In addition, congenital malformations, one leg is deformed to help people who have abnormally short life even if the purpose of this operation is to receive a lot of help to increase the short leg bone walking. However, if both legs are forcibly stretched in a short person, even if the patient suffers from pain and social costs, he may not be able to walk normally due to unexpected side effects.
따라서, 성장을 촉진시키기 위해서는 인스턴트 식품의 섭취를 줄이고 영양의 균형화, 적절한 운동과 오염 환경의 제거가 필요하며, 이 중에서도 영양의 균형화는 필수적인 요소이다. 이러한 영양의 균형화를 이루기 위하여, 부작용 없고 효과있는 건강보조식품이 새로운 관심의 대상으로 떠오르고 있다. 즉 기능성 물질을 함유한 건강보조식품은 이제까지 우리의 신체를 유지시켜 주는 단순한 식품이라는소극적인 개념에서 건강의 증진, 질병의 예방 및 치료에 목적을 두어 개발이 진행되고 있다.Therefore, in order to promote growth, it is necessary to reduce the intake of instant foods, to balance nutrition, to remove proper exercise and polluting environment, and to balance nutrition. To achieve this nutritional balance, health supplements that are effective without side effects are emerging as a new target of interest. In other words, health supplements containing functional substances have been developed for the purpose of promoting health, preventing and treating diseases from the passive concept of simple foods that maintain our bodies.
따라서, 이러한 부작용이 없으면서 현대 어린이나 청소년의 영양소 섭취의 불균형에 따른 제반 문제점을 해결하고 건강을 유지시키며 자연스럽게 성장을 유도하는 기능성 물질 개발이 절실하게 대두되고 있다.Therefore, there is an urgent need to develop functional materials that solve the problems caused by the imbalance of nutrient intake of modern children and adolescents, maintain health, and naturally induce growth without these side effects.
이에, 본 발명자들은 상기와 같은 문제점을 개선시키기 위하여 뼈의 발육과 면역력을 증강시키는 물질인 홍화씨, 맥아, 녹각, 토사자, 석창포, 복분자. 백복령, 산사자를 선별하여 이를 특정 비율로 배합한 결과, 어린이의 성장발육과 면역기능강화에 효과가 있음을 확인하여 이를 개발하였다.Accordingly, the present inventors safflower seed, malt, greenery, earth and sand, Seokchangpo, Bokbunja to improve the above problems, a substance that enhances bone development and immunity. As a result of screening Baekbokyeong and Sansa, and combining them in a specific ratio, it was confirmed that it is effective in the growth development and immune function enhancement of children.
결국, 본 발명은 전체 조성물 함량 중 홍화씨 15 ∼ 45중량%, 맥아 10 ∼ 35중량%, 녹각 및 복분자 각각 6 ∼ 28중량%, 토사자 및 석창포는 각각 4 ∼ 20중량%, 그리고 백복령 및 산사자는 각각 3 ∼ 18중량% 포함하는 생약제 조성물을 제공하는 데 그 목적이 있다.As a result, the present invention is 15 to 45% by weight of safflower seeds, 10 to 35% by weight of malt, 6 to 28% by weight of green and bokbunja respectively, 4 to 20% by weight of earth and sand spears, respectively, and Baekbokyeong and mountain lion respectively. The purpose is to provide a herbal composition comprising 3 to 18% by weight.
본 발명은 생약제 조성물에 관한 것으로 이에 대해 보다 구체적으로 살펴보면 다음과 같다.The present invention relates to a herbal composition as described in more detail as follows.
우선, 본 발명은 전체 조성물 함량 중 홍화씨 15 ∼ 45중량%, 맥아 10 ∼ 35중량%, 녹각 및 복분자 각각 6 ∼ 28중량%, 토사자 및 석창포는 각각 4 ∼ 20중량%, 그리고 백복령 및 산사자는 각각 3 ∼ 18중량% 포함하는 생약제 조성물을 그 특징으로 한다.First, the present invention is 15 to 45% by weight of safflower seeds, 10 to 35% by weight of malt, 6 to 28% by weight of green and bokbunja respectively, 4 to 20% by weight of earth and sand spears, respectively, and Baekbokyeong and mountain lion respectively. It is characterized by the herbal composition containing 3 to 18 weight%.
일반적으로, 키가 작다는 것은 골단연골과 근육의 발달이 여러 가지 원인으로 인하여 지체되어 있다는 것이다. 따라서, 키를 크게 하는 치료는 골단연골과 근육이 크게 자라도록 뼈의 발육에 좋고 완전한 영양의 조화를 이루는 식품의 섭취와 골단연골의 성장선을 자극할 수 있는 체조를 병행해야 한다.In general, being short means that the development of epiphyseal cartilage and muscles is delayed due to various causes. Therefore, the treatment to increase the height should be combined with the gymnasium that can stimulate the growth line of the epidermal cartilage and the intake of foods that are good for the development of the bone and the perfect nutrition to grow the epiphyseal cartilage and muscles.
체조는 사람 스스로가 알아서 할 수 있으나, 골단연골과 근육의 발달, 즉 뼈의 발육에 좋은 식품은 외부에서 선별하여 섭취하여야만 한다.Gymnastics can be done by oneself, but foods that are good for the development of epiphyseal cartilage and muscles, that is, bone development, must be taken from the outside.
본 발명에서는 한약재로 사용되고 있는 여러 가지 생약재 중에서 뼈의 발육과 면역력을 증강시키는 물질인 홍화씨, 맥아, 녹각, 토사자, 석창포, 복분자. 백복령, 산사자를 선별하여 이를 배합한 조성물을 섭취할 경우 성장 촉진, 특히 뼈의 발육을 촉진시킴으로써 키를 크게 하는 효과를 얻을 수 있다. 또한, 면역능력을 향상시켜 질병으로부터 예방할 수 있다.In the present invention, safflower seed, malt, greenery, earth and sand, Seokchangpo, Bokbunja are substances that enhance bone development and immunity among various herbal medicines used as herbal medicines. When baekbokyeong, hawthorn screening and ingesting a composition containing the same can increase the height by promoting growth, especially bone growth. In addition, it is possible to prevent the disease by improving the immune capacity.
본 발명에서 사용된 생약재인 홍화씨(Flos carthami)는 국화과에 속한 1년생 초본인 잇꽃의 화판(花瓣)으로서, 골조직 세포의 기능을 강화시켜 뼈의 발육을 촉진시키며, 골절 또는 염좌로 인한 뼈의 손상을 빠르게 회복시켜 주고, 망상골을 치밀하게 하여 뼈의 건강상 척도인 골밀도를 높여준다. 이 홍화씨의 사용량은 조성물 전체 조성물 함량중 15 ∼ 45중량%가 적합하다.Herbal safflower used in the present invention (Flos carthami) is a drawing board of the annual herbaceous safflower belonging to the Asteraceae, it promotes bone growth by enhancing the function of bone tissue cells, bone damage caused by fracture or sprain It quickly restores, densely reticular bones to increase bone density, a health measure of bones. The amount of safflower seed used is suitably 15 to 45% by weight of the total composition content of the composition.
또한, 본 발명에서 사용된 맥아는 기를 돕고[益氣] 중초를 조화시키며[調中] 설사를 멎게 하고 허한 것을 보한다. 또한 5장을 든든하게 하는데 오랫동안 먹으면 건강해지며 몸이 윤택해진다[본초]. 이러한 맥아의 사용량은 전체 조성물 함량 중 10 ∼ 35중량%이다.In addition, the malt used in the present invention aids the qi, harmonizes the middle and swelling diarrhea, and sees it as poor. In addition, you can eat 5 sheets to eat for a long time to be healthy and healthy body [herb]. The amount of such malt used is 10 to 35% by weight of the total composition content.
그리고, 본 발명에서 사용된 녹각(鹿角, Cornu cervi)은 녹용이 완전히 성장하여 모가 박락하고 경화되어 골절이 된 노각(老角)으로서, 뼈 발육의 필수적인 칼슘을 공급하며, 척추에 작용하여 자세를 바르게 유지시키고, 성장 호르몬과 함께 성장에 영향을 주는 남성 호르몬 및 여성 호르몬의 분비를 촉진시킨다. 이의 사용량은 전체 조성물 함량 중 6 ∼ 28중량%이며, 이의 양으로서 충분한 호르몬 분비 효과를 얻을 수 있다.In addition, the rusted corn (鹿 角, Cornu cervi) used in the present invention is a furnace shell (老 角) that the antler was completely grown, the hair fell and hardened to fracture, supplying the essential calcium for bone development, and acting on the spine Keeps it right and promotes the secretion of male and female hormones that affect growth along with growth hormone. Its usage amount is 6 to 28% by weight of the total composition content, the amount can be obtained a sufficient hormone secretion effect.
본 발명에서 사용된 토사자(兎絲子, Semen cuscutae)는 매꽃과에 속한 1년생 기생성 만초인 새삼 및 갯실 새삼과 동속 근녹식물의 성숙한 종자로서, 신장과 간장을 보호하는 효과가 있는데 이러한 보호 작용은 성장발육을 촉진하는데 중요한 역할을 수행한다. 즉, 간은 혈을 저장하는 장기이며 근육의 기능을 주관하여 운동과 관계가 깊으며, 사람이 밤에 잠을 잘 때 혈액이 간으로 모이고 낮에 활동할 때는 각각 활동하는 기관과 경맥으로 보내져 그 기능을 수행하게 함을 뜻하며, 혈류량을 조절하는 기능을 갖고 있다. 만약 간혈이 부족하게 되면 전신 각처에 분포되어 있는 혈액이 인체 생리활동의 수요에 충분한 공급이 불가능하게 된다. 따라서 간혈이 충분해야만 비로소 영양소가 근육에 스며들어 각각의 조직과 기관을 건강하고 성장발육을 촉진시킬 수 있다. 신장의 기능은 정(精)을 간직하고 골(骨)을 주관하며 성장발육과 생식을 주관하고 골수를 생성하며 뇌와 통한다. 한의학에서 신장은 선천적인 기능을 간직한 장기로 파악하고 있는데 신장의 정이 충혈하여야만 뇌수, 골격, 근맥, 피부, 근육, 모발 등의 형체와 조직이 점차적으로 생장하여 완전하게 되므로 몸이 성장 발육할 수 있는 것이다. 만약 신의 기능에 장애가 생긴다면 뇌수, 골격, 근맥, 피부, 근육 등에 영양이 부족하여 호르몬 분비 저하로 인해 성장장애가 초래될 수 있다. 이의 사용량은 전체 조성물 함량중 4 ∼ 20 중량%이며, 이의 사용량으로서 뼈나 근육의 발육 효과를 얻을 수 있다.Sesa cuscutae (兎 絲 子, Semen cuscutae) used in the present invention is a mature seed of the same-year-old parasitic herbaceous ginseng and seaweed bird ginseng belonging to the plum family, and has the effect of protecting the kidneys and liver. Plays an important role in promoting growth and development. In other words, the liver is an organ that stores blood, and the function of muscles is deeply related to exercise.When a person sleeps at night, the blood gathers into the liver, and when it is active during the day, it is sent to the organs and meridians that are active. It means to perform, and has the function of regulating blood flow. If liver blood is scarce, blood distributed throughout the body will not be able to supply enough to meet the needs of human physiology. Therefore, enough blood is enough to allow nutrients to penetrate the muscles to promote healthy growth and growth of individual tissues and organs. The function of the kidney is to keep the jeong (精), to control the bone (관), to control growth and reproduction, to produce the bone marrow and communicate with the brain. In oriental medicine, the kidney is regarded as an organ with innate functions. The kidneys are congested only when the shape and tissues of the brain, skeleton, root vein, skin, muscle, and hair are gradually grown and perfected, so that the body can grow and develop. will be. If there is a disorder in the function of the kidneys, lack of nutrients in the brain, skeleton, muscles, skin, muscles, etc. may cause growth disorders due to a decrease in hormone secretion. Its amount is 4 to 20% by weight of the total composition content, the amount can be used to obtain the effect of bone or muscle development.
또한, 석창포(石菖蒲, 창포)는 심규[心孔]를 열어 주고 5장을 보하며, 귀와 눈을 밝게 하며 목청을 좋게 하고 풍습으로 전혀 감각이 둔해진 것을 치료하며 뱃속의 벌레를 죽인다. 이와 벼룩 등을 없애며 건망증을 치료하고 지혜를 나게 하며 명치 밑이 아픈 것을 낫게 한다. 이의 사용량은 전체 조성물 함량 중 4 ∼ 20 중량%가 바람직하다.In addition, Seokchangpo (石菖蒲, irises) open Shimgyu (心 孔), see Chapter 5, brightens the ears and eyes, improves the throat, heals the sense of dullness at all, and kills bugs in the stomach. Eliminates fleas and teeth, heals forgetfulness, makes wisdom, and heals the sick under the name. Its usage amount is preferably 4 to 20% by weight of the total composition content.
그리고, 본 발명에서 사용된 복분자(覆盆子, Fructus rubi)는 장미과에 속한 낙엽관수인 복분자 딸기 및 동속 근녹식물의 미성숙한 과실로서, 뇌화수체에 작용하여 성장 호르몬 분비를 왕성하게 하며, 오장육부 기능을 안정화시켜 신체의 균형잡힌 성장을 유지시켜 주고, 관절부에 인대, 근육 발육을 원활하게 한다. 본 발명에서 충분한 근육 발육 효과를 얻을 수 있는 이의 사용량은 전체 조성물 함량 중 6 ∼ 28중량%가 바람직하다.In addition, the bokbunja (覆盆子, Fructus rubi) used in the present invention is an immature fruit of the bokbunja strawberry and the same root green plant of deciduous waters belonging to the Rosaceae family, and acts on the cerebrospinal fluid to stimulate the secretion of growth hormones Stabilize the body to maintain a balanced growth of the body, joints and ligaments, muscle development is smooth. In the present invention, the amount thereof that can obtain sufficient muscle development effect is preferably 6 to 28% by weight of the total composition content.
또한, 백복령(白茯笭, Poria)은 소나무과에 기생하는 구멍장이 버섯과에 속하는 일종의 균괴로서 소나무를 베어낸 썩은 나무에 기생하여 성장하고, 건비, 삼습, 안신, 생진 등의 효능이 있어 각종 질병에 많이 응용되어 왔다. 이 생약재는 소화기능을 튼튼하게 하여 영양분이 잘 흡수되도록 하며, 심장기능을 안정화시켜 스트레스를 없애주고, 키가 잘 때 크는 현상에 따라 숙면을 취하게 함으로써, 불면, 수면 부족으로 인한 성장 장애를 없애준다. 이의 사용량은 전체 조성물 함량 중 3 ∼ 18중량%가 바람직하며, 이 양으로도 소화작용을 돕는데 충분하기 때문이다.In addition, Poria is a type of fungi belonging to the family of fungi, which are parasitic in the pine family. They grow on the rotten trees that cut the pine trees. It has been applied to many. This herbal medicine strengthens digestive function, absorbs nutrients well, stabilizes heart function, eliminates stress, and gets a good night's sleep according to the height of sleep. give. Its usage amount is preferably 3 to 18% by weight of the total composition content, because even this amount is enough to help digestion.
본 발명에서 산사자(山査子, 찔광이)는 식적(食積)을 삭히고 오랜 체기를 풀어 주며 기가 몰린 것을 잘 돌아가게 하고 적괴(積塊), 담괴(痰塊), 혈괴(血塊)를 삭히고 비(脾)를 든든하게 하며 가슴을 시원하게 하고 이질을 치료하며 종창을 빨리 곪게 하여 면역능력을 증강시켜준다. 이의 사용량은 전체 조성물 함량 중 3 ∼ 18중량%이 바람직하다.Sansa (山 산 子, stab) in the present invention is to remove the food (食 積) and to release the old body, and to return to the well flocked, to remove the red mass (담), lump (痰 塊), blood clot (고) and rain (脾) ) Strengthens the chest, cools the body, treats dysentery and swells quickly, boosting immunity. Its usage amount is preferably 3 to 18% by weight of the total composition content.
이하, 본 발명을 실시예에 의하여 더욱 상세히 설명하겠는 바, 본 발명이 이에 한정되지 않음은 자명할 것이다.Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.
<실시예><Example>
상기와 같은 성분들로 본 발명의 성장 호르몬 분비 촉진제를 제조하되 홍화씨 20중량%, 맥아 15중량%, 녹각 15중량%, 복분자10중량%, 토사자 10 중량%, 석창포 10중량%, 백복령 10중량%, 산사자 10 중량%로 구성하고 이는 각각의 원료를 엄선 선별한 후, 세척하여 배합비율대로 정량하고, 정량한 원료에 정제수를 첨가하여 추출 여과한 후, 감압농축하여 살균한 다음, 냉각시켜 제조하였다.Prepare the growth hormone secretagogue of the present invention with the above ingredients, but safflower seed 20% by weight, malt 15% by weight, green rust 15% by weight, bokbunja 10% by weight, earth and sand 10% by weight, Seokchangpo 10% by weight, Baekbokyeong 10% by weight , 10% by weight of hawthorn, which was carefully selected for each raw material, washed, quantified according to the mixing ratio, purified water was added to the quantified raw material, extracted and filtered, concentrated under reduced pressure, sterilized, and cooled. .
<실험예 1>Experimental Example 1
성장호르몬 분비촉진효과Growth hormone secretagogue effect
체중이 17 ∼ 20g인 5주령 SPF-ICR계 암컷 마우스 15마리를 군당 5마리씩 골라 대조군 및 본 발명에 따른 상기 실시예 조성물 식이군으로 나누었다. 그리고, 대조군은 시판되는 일반적인 마우스 사료(제일사료)를, 본 발명에 따른 식이군은 위 사료 총 중량의 1 중량%와 5중량%를 배합하여 6주간 자유롭게 섭취하게 하였다. 그런 다음, 마취후 경동맥 혈액을 채취하여 성장호르몬 수치를 조사하였고, 그 결과를 다음 표 1에 요약하여 나타내었다.Fifteen five-week-old SPF-ICR-based female mice having a body weight of 17 to 20 g were selected from five groups per group and divided into a control group and a dietary group of the example composition according to the present invention. And, the control group was commercially available general mouse feed (first feed), the dietary group according to the present invention was allowed to freely ingest for 6 weeks by combining 1% by weight and 5% by weight of the total weight of the stomach feed. Then, carotid artery blood was collected after anesthesia, and growth hormone levels were examined. The results are summarized in Table 1 below.
이상에서와 같이, 성장호르몬 수치는 1 중량%나 5 중량% 식이군에서나 대동소이하게 나타났으나, 대조군에 비하여는 월등히 높은 수치를 나타냄을 확인할 수 있었다.As described above, the growth hormone level was found to be almost the same in the 1% by weight or 5% by weight diet group, but was found to be significantly higher than the control group.
<실험예 2>Experimental Example 2
면역기능 강화효과Immune function
체중이 80 ∼ 90g인 3주령 쥐(Sprague Dawley) 15마리를 군당 5마리씩 골라 각각 대조군, 본 발명에 따른 상기 실시예 조성물 1 중량% 식이군, 5 중량% 식이군에 배정하였다. 우선, 대조군은 실험예 1에서와 같이 시판되는 일반적인 쥐사료(제일사료)를, 그리고 본 발명에 따른 식이군은 위 사료 총 중량의 1 중량%와 5중량%를 배합하여 6주간 자유롭게 섭취하게 하였다. 그런 다음, 2주에 한번씩 심장천공으로 채혈한 후 혈액내 글로블린 수치를 비교 관찰하였고, 그 결과를 다음 표 2에 요약하여 나타내었다.Fifteen three-week-old rats (Sprague Dawley) weighing 80 to 90 g were selected for 5 groups per group, and each group was assigned to a control group, 1% by weight dietary group and 5% by weight dietary group according to the present invention. First, the control group was a commercial rat feed (first feed), as in Experimental Example 1, and the dietary group according to the present invention was allowed to freely ingest for 6 weeks by combining 1% by weight and 5% by weight of the total weight of the stomach feed . Then, blood samples were collected by cardiac puncture every two weeks, and then blood globulin levels were compared and observed, and the results are summarized in Table 2 below.
이상에서와 같이, 본 발명에 따른 조성물 식이군에서 면역기초물질인 글로블린의 함량이 대조군에 비하여 현저히 높아짐을 확인할 수 있었다.As described above, the composition of the composition according to the present invention was confirmed that the content of the globulin as an immunobased substance is significantly higher than the control group.
이상에서 상세히 설명하고 입증하였듯이, 본 발명은 성장호르몬 분비촉진용 생약제 조성물에 관한 것이다. 따라서, 본 발명에 따른 상기 생약재 조성물은 부작용이 없어 안전할 뿐만 아니라, 성장호르몬 분비촉진 및 면역기능을 강화하는데 매우 우수한 효과가 있다.As described and demonstrated in detail above, the present invention relates to a herbal composition for promoting growth hormone secretion. Therefore, the herbal composition according to the present invention has no side effects and is not only safe, but also has an excellent effect on promoting growth hormone secretion and enhancing immune function.
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| US11324795B2 (en) | 2013-11-25 | 2022-05-10 | University-Industry Cooperation Group Of Kyung Hee University | Composition comprising Hordeum vulgare extract for preventing or treating short stature |
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