KR20040061731A - Patch kit comprising the water-soluble adhesive solution and the patch containing water-soluble adhesive layer, and a method for dental-whitening by using thereof - Google Patents

Abstract

PURPOSE: Provided are a patch kit consisting of patch containing aqueous adhesive and an aqueous adhesion layer and a method for whitening tooth. The patch kit continuously releases substances which are effective for whitening teeth and preventing tooth decay. CONSTITUTION: A patch kit for tooth is characterized by comprising aqueous adhesive solution as a first agent and an aqueous adhesion layer as a second agent. The first agent contains one of tooth whitening components or tooth decay preventing components as an active ingredient, as well as aqueous adhesion layer, neutralizing agent, emulsifier and stabilizing agent.

Description

Patch kit comprising the water-soluble adhesive solution and the patch containing water-soluble adhesive layer, and a method for dental-whitening by using pretty}

The present invention relates to a patch kit composed of a patch comprising a water-soluble pressure-sensitive adhesive solution and a water-soluble pressure-sensitive adhesive layer, and a tooth whitening method using the same. More specifically, the present invention, the first water-soluble pressure-sensitive adhesive solution containing an active ingredient capable of providing a whitening effect, tooth decay prevention effect or tooth remineralization effect on the teeth, one or more layers of water-soluble pressure-sensitive adhesive layer, protecting the tooth adhesion site Tooth patch kit comprising a layer and an exposed part protective layer and comprising a patch second agent comprising a water-soluble adhesive layer having a function to effectively attach the first agent to the tooth and a tooth whitening method using the same will be.

In general, the purpose of using the composition for oral cavity can be divided into those relating to the teeth and gums according to the target site. Among them, the purpose of the composition for oral cavity targeting the teeth may include caries prevention, tooth whitening, tooth remineralization, and the like. Oral compositions currently on the market for this purpose contain fluorine, calcium and the like for the prevention of tooth decay and various kinds of peroxides, phosphates and the like for the whitening of teeth.

However, these medicinal ingredients are difficult to show the effect because they do not react to the teeth for a long time due to the disadvantage that the oral compositions are prepared in a formulation such as toothpaste and mouthwash and spit after short-term use. For this reason, various functional and direct tooth-adhesive patching agents, focusing on the whitening effect of teeth, have been made as a method of directly contacting various active ingredients and increasing the contact time thereof.

U. S. Patent No. 5,326, 685 discloses that a tooth whitening agent in gel form is placed between a porous material such as a sponge and a water impermeable film and then directly attached to a tooth. In this case, the tooth whitening agent gradually acts on the tooth through the porous material while the tooth is in contact with the tooth, thereby exhibiting a whitening effect. However, it is inconvenient to use because the thickness of the material attached to the tooth is too thick, so it is inconvenient to use. There is this.

U.S. Patent Nos. 5,879,691, 5,894,017, and 5,891,453 disclose delivery systems for applying professional whitening products to teeth by applying thin, flexible polyethylene strips. The ease of use is further improved by not using a mouse tray, but the problem with applying the gel form remains. In other words, by using carbopol (carbopol) as the main polymer, the adhesiveness to the polyethylene strip and teeth is good, there is an advantage in the formulation, but the feeling of use may be inferior.

U.S. Patent No. 5,310,563 discloses a formulation in which a Dow Corning 3179 Dilatant Compound is mixed with an active ingredient to form a form and then lightly pressed onto the tooth and easily peeled off. However, in the case of this formulation, the active ingredient is in a form encapsulated in a polymer, so that the active ingredient is difficult to come out in a short time, so that a long contact time is required to obtain a whitening effect.

In addition, Korean Patent Publication No. 2001-13448 discloses a tooth whitening agent that provides a sticky adhesion between a tooth surface and a strip by coating a tooth enamel adhesion layer containing a tooth whitening agent on a thin and flexible strip, in which case a tooth The thinner the adhesive material, the less foreign body feels when used. However, the tooth enamel adhesion layer is a water-soluble substance, which is dissolved by water on the surface of the tooth or saliva in the oral cavity, and there is a risk of irritation of the oral mucosa. Since the effect of releasing the drug is small and is applied directly to the tooth in the form of a gel, a lot of residues remain on the tooth when desorption after use, so it has to be removed by brushing teeth.

In addition to the above drawbacks, although the tooth is directly wrapped with a patch, each individual's tooth size is different, so that the gel containing peroxide can be in direct contact with the gums to stimulate it, and the concentration of the active ingredient over time It also shows a tendency to decrease and also shows the disadvantage that it is effective only when it is wrapped around the tooth for a long time.

Accordingly, the present inventors have studied to solve the disadvantages of the conventional oral composition and patch and to develop a more effective tooth decay prevention or whitening agent, the tooth whitening effect when applied to the tooth composition divided into 1 agent and 2 agents Found very good. That is, as an active ingredient, a water-soluble adhesive solution containing peroxide, fluorine, calcium, and the like in an effective amount, an emulsifier, and a stabilizer in an effective amount, which can be applied to a tooth using a brush, and a first agent Patch containing a water-soluble adhesive layer containing a water-soluble adhesive, a crosslinking agent, an emulsifier, a decomposition accelerator and a stabilizer, a tooth attachment layer protective layer and an exposed portion protective layer in order to continuously release the active ingredient to the tooth for a long time. When applied to the teeth in combination with the second agent of the formulation, the present invention was found to achieve an excellent effect on whitening or caries prevention, remineralization of the teeth while minimizing oral irritation and foreign body.

Accordingly, an object of the present invention is to provide a dental patch kit consisting of a patch comprising a water-soluble pressure-sensitive adhesive solution and a water-soluble pressure-sensitive adhesive layer.

Another object of the present invention is to provide a method for preventing tooth whitening or tooth decay using the tooth patch kit.

1 is a flow chart showing a method of using a dental patch kit according to the present invention.

Figure 2 is a view showing a case of using the entire tooth patch kit according to the present invention.

Figure 3 is a view showing the structure of a patch including a water-soluble pressure-sensitive adhesive layer of the dental patch kit according to the present invention.

<Explanation about sign of drawing>

10: gum

11: teeth

12: water-soluble adhesive solution applied to the teeth

20: patch containing a water-soluble adhesive layer

21: exposed layer protective layer

22: water-soluble adhesive layer

23: protective layer on the attachment site

In order to achieve the above object, the present invention is characterized by providing a dental patch kit consisting of a patch comprising a water-soluble pressure-sensitive adhesive solution first agent and a water-soluble pressure-sensitive adhesive layer containing a whitening component or caries prevention component. That is, the first water-soluble pressure-sensitive adhesive solution prepared separately is applied to the teeth using a brush, and then the exposed water protective layer, the adhesion area protective layer, and one or more layers of water-soluble pressure-sensitive adhesive layers formed between the two layers. It is characterized by providing a tooth patch kit for applying a tooth whitening component or caries prevention component to the teeth more effectively by fixing with a patch second agent.

The present invention is also characterized by providing a method for continuously achieving a tooth whitening or caries prevention effect by applying a patch second agent comprising a water-soluble adhesive solution first agent and a water-soluble adhesive layer to the teeth.

Hereinafter, the present invention will be described in more detail.

The first water-soluble adhesive solution constituting the patch kit for teeth according to the present invention is a gel containing one or more whitening ingredients or caries prevention components, put it in a separate container and apply thinly to the teeth using a brush, whitening It contains components, caries prevention components, water-soluble adhesives, neutralizing agents, emulsifiers and stabilizers as constituents. In addition, the first water-soluble pressure-sensitive adhesive solution may optionally further contain a dental remineralization component.

One or more components selected from the group consisting of peroxides, metal chlorite, percarbonates, peroxides, and mixtures thereof may be used as the whitening component, which is one of the components of the water-soluble pressure-sensitive adhesive solution, but is not limited thereto.

In addition, as one of the components of the water-soluble pressure-sensitive adhesive solution, one or more selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride, calcium glycophosphate, calcium lactate and mixtures thereof may be used. However, it is not limited thereto.

It is preferable to use 0.01-40.0 weight% of the said whitening component or the tooth decay prevention component with respect to the total weight of a water-soluble adhesive solution.

Patch second agent comprising a water-soluble adhesive layer constituting the patch for the tooth according to the present invention to secure the first agent applied to the tooth in contact with the teeth to effectively deliver the whitening or caries prevention components A water-soluble adhesive, a neutralizing agent, a crosslinking agent, an emulsifier, a decomposition accelerator, and a stabilizer are components. In addition, the patch second agent including the water-soluble pressure-sensitive adhesive layer may optionally further contain a dental remineralization component. This second agent comprises an exposed site protective layer, an adhesion site protective layer and a water-soluble adhesive layer formed between the two layers (FIG. 3).

Hereinafter, the components constituting the dental patch kit according to the present invention will be described in detail.

The water-soluble pressure-sensitive adhesive component of the water - soluble pressure- sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer in the tooth patch kit according to the present invention is to enhance the adhesion of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer to the tooth enamel. As the pressure-sensitive adhesive, one or more selected from the group consisting of gelatin, polyacrylic acid, polyvinyl alcohol, xanthan gum, galang gum, sodium alginate, polyvinylpyrrolidone, polyvinylformamide, carboxymethylcellulose and carboxypolymethylene may be used. But it is not limited thereto. Such water-soluble pressure-sensitive adhesive is preferably used in an amount of 0.01 to 70.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer.

Another component of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer in the dental patch kit according to the present invention corrector Is to neutralize the water-soluble adhesive to obtain the appropriate viscosity and to improve the safety of the teeth and oral mucosa. The neutralizing agent may be one or more selected from the group consisting of sodium hydroxide, potassium hydroxide, triethanolamine, citric acid, sodium citrate, sodium phosphate, and the like, but is not limited thereto. Such a neutralizing agent is preferably used in an amount of 0.01 to 10.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer (.

Another constituent of the emulsifier of the dental patch kit a water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer of according to the present invention are intended to uniformly emulsify the water-soluble pressure-sensitive adhesive solution and composition of the water-soluble pressure-sensitive adhesive layer. Such emulsifiers may be, but are not limited to, one or more selected from the group consisting of polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, polyglyceryl fatty acids, and fatty acid sugar esters. Such emulsifier is preferably used in an amount of 0.01 to 5.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer.

The stabilizing agent which is another component of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer in the dental patch kit according to the present invention is to stabilize the effective whitening components. The stabilizer may be one or more selected from the group consisting of sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride, and laponite, but is not limited thereto. Such stabilizer is preferably used in an amount of 0.01 to 1.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer.

Another component of the water-soluble adhesive layer of the dental patch kit according to the present invention is Crosslinking agent Is to crosslink the glass reactor of the water-soluble pressure-sensitive adhesive to enhance the physical strength of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer. Such crosslinkers include glyoxal; Zinc salts such as zinc oxide and zinc chloride; Aluminum salts such as aluminum glycinate and aluminum sulfate; Calcium salts such as calcium chloride and calcium oxide; And it may be used one or more selected from the group consisting of magnesium salts such as magnesium chloride, magnesium oxide, but is not limited thereto. Such a crosslinking agent is preferably used in an amount of 0.01 to 5.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer.

In the dental patch kit according to the present invention, the decomposition accelerator, which is a component of the water-soluble adhesive layer, promotes the decomposition of the effective whitening component, thereby increasing the concentration of hydroxy radicals effective for tooth whitening and reducing the adhesion time of the adhesive layer. To reduce the feeling of foreign body to teeth. Such decomposition promoters may be one or more selected from aluminum salts and iron salts, but are not limited thereto. Such decomposition accelerators may be used in an amount of 0.01 to 5.0% by weight based on the total weight of the water-soluble pressure-sensitive adhesive layer.

The tooth patch kit according to the present invention may further contain components for dental whitening, as well as prevention of tooth whitening or tooth decay. In this case, the components for remineralization of the tooth include calcium source components such as calcium lactate and calcium chloride in the water-soluble pressure-sensitive adhesive solution, and personnel components such as anhydrous sodium dihydrogen phosphate and trisodium phosphate in the water-soluble pressure-sensitive adhesive layer, respectively. When the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer is used at the same time, the tooth remineralization effect is to be shown. In the above, the calcium source components and personnel components are not limited thereto.

The water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer in the dental patch kit according to the present invention may further contain a fragrance in an amount of 0.001 ~ 1.0% by weight in addition to the essential components as described above.

In addition to the above components, the water-soluble adhesive solution of the dental patch kit according to the present invention may optionally contain an active ingredient effective for oral diseases. These ingredients include gum disease prevention components such as sodium chloride, tocopherol acetate, pyridoxine hydrochloride, allantoin, allantoin chlorohydroxyaluminum, tranexamic acid and aminocaproic acid, and prevention of tartar deposition such as sodium pyrophosphate, triclosan and cetylpyridinium chloride. Antibacterial ingredients such as chlorhexidine gluconate may be used, but are not limited thereto.

In the dental patch kit according to the present invention, the water-soluble adhesive solution of the first agent is preferably contained in an opaque container that blocks light in order to stabilize peroxides, and to minimize the contact surface with air, to make the discharge port of the brush as small as possible. good.

The patch including the water-soluble adhesive layer of the tooth patch kit according to the present invention is exposed to prevent the water-soluble adhesive solution attached to the teeth to remain intact in the oral cavity for a long time, and also to prevent the penetration of the active ingredient such as a whitening agent into the oral cavity. A site protective layer. In the present invention, a conventional film used in a general transdermal patch may be used as an exposed portion protective layer without particular limitation. As the film that can be used for the exposed portion protective layer, a polymer film or a nonwoven fabric may be used. Particularly, in order to firmly bond with the water-soluble adhesive layer, it is possible to use a scratched or embossed film or a film laminated with a thin nonwoven fabric. desirable. However, it is not limited to this.

The patch including the water-soluble adhesive layer in the tooth patch kit according to the present invention includes an attachment site protective layer to continuously attach the water-soluble adhesive solution to the tooth surface. In the present invention, as a protective layer for the attachment site, a conventional one used in the general transdermal patch application field can be used without particular limitation. The adhesion site protective layer may be a polypropylene film, a polyethylene terephthalate film or a polyvinyl chloride film treated with fluorine or silicon, but is not limited thereto.

Method for producing a water-soluble pressure-sensitive adhesive solution first agent in the patch kit for teeth according to the present invention is as follows,

(1) adding a water-soluble pressure-sensitive adhesive to the solvent, heating and stirring to dissolve uniformly, and then adding and mixing a neutralizing agent, an emulsifier, and a stabilizer to the solution;

(2) adding a whitening component or a cavities prevention component to the mixture and stirring to stop the stirring when the mixture is in a uniform state, degassing and cooling the vacuum; And

(3) after placing the solution in an opaque container, covering the lid with a small discharge port and closing the lid to which the brush is attached. However, it is not limited to this method.

Method for producing a patch second agent comprising a water-soluble pressure-sensitive adhesive layer of the dental patch kit according to the present invention is as follows,

(A) adding a water-soluble pressure-sensitive adhesive to a solvent and dissolving uniformly by heating and stirring, and then adding and mixing a neutralizing agent, an emulsifying agent, a decomposition promoter and a stabilizing agent to the solution;

(B) adding a crosslinking agent dispersed in purified water to the mixed solution and stirring to stop the agitation when the mixed solution is in a uniform state, vacuum degassing, and then cooling;

(C) applying a uniform thickness of about 10 to 1000 μm to the protective layer of the attachment site on the film by using a coater, and then drying at room temperature by passing through a tunnel equipped with a blowing facility; And

(D) laminating an exposed portion protective layer to the layer. However, it is not limited to this method.

In the above (1) and (a), purified water may be used as the solvent for dissolving the water-soluble adhesive, but is not limited thereto. In addition, fragrances may be further added together with emulsifiers and stabilizers.

The patch containing the water-soluble pressure-sensitive adhesive layer prepared by the above method is aged for 12 to 48 hours at room temperature or 37 ℃ thermostat, and then cut into a shape that is easy to attach to the teeth and finally formulated.

The method of using the dental patch kit according to the present invention is as follows. The first water-soluble pressure-sensitive adhesive solution is applied to the tooth surface using a brush, and then applied thereon as a patch second agent. In the treatment of the dental patch kit, only the front part where the teeth are visible may be targeted (see FIG. 1), or may be treated as if it covers the entire tooth (see FIG. 2).

Dental patch kit according to the present invention is, firstly, excellent adhesion to the teeth; Second, due to the lamination of the protective layer of the exposed area, the circular shape is maintained in the oral cavity for a long time, so that the whitening component or the caries prevention component is prevented from penetrating into the oral cavity, thereby minimizing oral irritation; Third, foreign matter is minimized when used in the form of a thin sheet; Fourth, the whitening component has high stability in the formulation through the separation of the first agent and the second agent; Fifth, there is a characteristic that can continuously release the whitening ingredients effective for teeth whitening.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. However, the scope of the present invention is not limited thereto, and modifications commonly known in the art may be performed, and such modifications are also included in the scope of the present invention.

[Examples and Comparative Examples] Preparation of First Agent and Second Agent

The patch 2 agent including the water-soluble pressure-sensitive adhesive solution first agent and the water-soluble pressure-sensitive adhesive layer was prepared in the composition of Table 1 below.

[Examples 1 and 2]

The first agent was prepared according to the following procedure. Ionized water in which sodium hydroxide was dissolved was added to an aqueous polyacrylic acid solution, followed by stirring while heating at about 60 to 70 ° C. A solution in which polyoxyethylene (20) sorbitan stearate, tetrasodium pyrophosphate, and sodium sterate was dissolved was added thereto, followed by stirring for 20 minutes while maintaining the temperature at 60 to 70 ° C. 35% hydrogen peroxide was added to the mixed solution, followed by further stirring for 10 minutes, followed by vacuum degassing and cooling to 50 ° C.

A second agent was prepared according to the following procedure. Ionized water in which sodium hydroxide was dissolved was added to an aqueous polyacrylic acid solution, followed by stirring while heating at about 60 to 70 ° C. To this was added a solution in which polyoxyethylene (20) sorbitan stearate, tetrasodium pyrophosphate, sodium sterate and agar were dissolved, followed by stirring for 20 minutes while maintaining the temperature at 60 to 70 ° C. Potassium aluminum sulfate was added to the mixture, followed by further stirring for 10 minutes, followed by vacuum degassing and cooling to 50 ° C. The solution was applied to a PET film with a uniform thickness of about 300 μm using a coater, then dried at room temperature for 5 minutes, and the PE film was laminated to the layer. Thereafter, the mixture was cut to an appropriate size and then crosslinked at a temperature of 50 to 60 ° C. for 3 days to prepare.

[Comparative Example 1]

Ionized water in which sodium hydroxide was dissolved was added to an aqueous polyacrylic acid solution, followed by stirring while heating at about 60 to 70 ° C. To this was added a solution in which polyoxyethylene (20) sorbitan stearate, tetrasodium pyrophosphate, sodium sterate and agar were dissolved, followed by stirring for 20 minutes while maintaining the temperature at 60 to 70 ° C. 35% hydrogen peroxide and potassium aluminum sulfate were added to the mixture, followed by further stirring for 10 minutes, followed by vacuum degassing and cooling to 50 ° C.

The solution was applied to a PET film with a uniform thickness of about 300 μm using a coater, then dried at room temperature for 5 minutes, and the PE film was laminated to the layer. Thereafter, the mixture was cut to an appropriate size and then crosslinked at a temperature of 50 to 60 ° C. for 3 days to prepare.

[Comparative Example 2]

Carboxypolyethylene was dispersed in glycerin, followed by stirring while maintaining ionized water at 40 to 50 ° C. When the carboxypolyethylene was completely dissolved, ionized water in which sodium hydroxide was dissolved was added and stirring continued. Then, polyoxyethylene (20) sorbitan stearate, tetrasodium pyrophosphate, and sodium stearate were added and stirred at room temperature for 20 minutes. Hydrogen peroxide was added to the mixed solution, followed by further stirring for 10 minutes, followed by vacuum degassing.

The solution was applied to a PET film with a uniform thickness of about 300 μm using a coater, then dried at room temperature for 5 minutes, and the PE film was laminated to the layer. It was then cut to a suitable size to prepare.

Furtherance Example 1 Example 2 Comparative Example 1 Comparative Example 2 The first 2nd The first 2nd Polyacrylic acid aqueous solution 40.0 40.0 40.0 40.0 40.0 - Carboxy Polyethylene - - - - - 2.0 Sodium hydroxide 2.5 2.5 2.5 2.5 2.5 0.2 Potassium aluminum sulfate 0.20 0.20 0.20 0.20 0.20 - Agar 1.0 1.0 1.0 1.0 1.0 - Tetrasodium pyrophosphate 0.5 0.5 0.5 0.5 0.5 0.5 glycerin 5.0 5.0 5.0 5.0 5.0 25.0 Polyoxyethylene (20) sorbitan stearate 0.7 0.7 0.7 0.7 0.7 0.7 Sodium stearate 0.10 0.10 0.10 0.10 0.10 0.10 Ferric chloride - 0.5 - 0.5 - - Hydrogen peroxide (35%) 8.57 - 4.29 - 8.57 8.57 Ionized water to 100 to 100 to 100 to 100 to 100 to 100

<Test Example 1> Measurement of the whitening effect on the teeth of the patch containing the present invention water-soluble pressure-sensitive adhesive solution and water-soluble pressure-sensitive adhesive layer

In order to measure the tooth whitening effect of the patch including the water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer of the present invention, 80 healthy male and female experimenters were selected and tested.

The original tooth chromaticity of the subject was measured using SHADEEYE-EX (SHOFU Co.LTD., Japan). Place the SHADEEYE-EX tip 2 mm above the maxillary left central incisoral cervical cervical surface, at a right angle so that light does not leak out to the outside, and irradiate the beam with light to measure and collect baseline data. The patches of Examples 1 and 2 and Comparative Examples 1 and 2 were applied twice each day to the upper and lower mandibular buccal for 30 minutes. During the test, he was allowed to eat food according to his or her usual diet, but coffee, cola, and tobacco were prohibited before the color measurement on the day of chromaticity measurement. Chromaticity was measured (secondary measurement) 14 days after the patch was used.

The results are shown in Tables 2 and 3, respectively.

Measurement result of change in tooth color after 2 weeks Baseline mean Average after 2 weeks Example 1 7.94 5.68 Example 2 7.96 6.15 Comparative Example 1 7.94 5.92 Comparative Example 2 7.93 6.08

Tooth whitening effect measurement result two weeks later Better Same Worse Example 1 17 (85%) 3 (15%) 0 (0%) Example 2 14 (70%) 5 (25%) 1 (5%) Comparative Example 1 15 (75%) 5 (25%) 0 (0%) Comparative Example 2 15 (75%) 4 (20%) 1 (5%)

From the above results, it can be seen that the patch kit for teeth to apply the patch containing the present invention water-soluble pressure-sensitive adhesive solution and the water-soluble pressure-sensitive adhesive layer at the same time excellent in whitening effect. In particular, the whitening effect of Example 1 was the best.

<Test example 2> Stability measurement of the whitening component of the patch containing this invention water-soluble adhesive solution and water-soluble adhesive layer

In order to measure the stability of the whitening component in the water-soluble pressure-sensitive adhesive solution according to the present invention, the following experiment was performed on the water-soluble pressure-sensitive adhesive solution of Example 1 having the composition of Table 1 and the hydrogel of Comparative Example 1.

The water-soluble adhesives were separated from the first agent of Example 1 and the patch of Comparative Example 1, and weighed precisely, and 20 ml of water was added to dissolve the contents. 20 ml of diluted sulfuric acid was added to the solution, and titrated with 0.02 mol / L potassium permanganate solution to obtain the amount of hydrogen peroxide as follows.

One month, three months and six months after the first measurement, the concentration of hydrogen peroxide was measured in the same manner, and the results are shown in Table 4.

Hydrogen peroxide concentration (%) Initial concentration 1 month later 3 months later 6 months later Example 1 2.99 2.98 2.98 2.95 Comparative Example 1 3.05 2.71 2.23 1.58

From the above results, it can be seen that the stability of the peroxide in the oral composition of the present invention, which is divided into the first agent and the second agent, is much superior to the stability of the conventional whitening patch.

As described above, the dental patch kit according to the present invention by applying a water-soluble adhesive solution first agent containing a whitening component or a tooth decay component to the teeth, and then attaching a patch second agent comprising a water-soluble adhesive layer Excellent adhesion to teeth, and due to the lamination of the protective layer on the exposed area, it maintains the original shape for a long time in the oral cavity, and is composed of one and two agents, so the stability of the whitening agent is excellent. In addition to minimizing irritation, it is a very useful invention that has excellent effects such as continuously releasing ingredients effective for preventing tooth whitening or tooth decay and exhibiting excellent effects in a short time.

Claims (12)

Dental patch kit comprising a water-soluble pressure-sensitive adhesive solution comprising a tooth active ingredient and a patch second agent comprising a water-soluble pressure-sensitive adhesive layer. The method of claim 1, wherein the first water-soluble pressure-sensitive adhesive solution comprises at least one of a whitening component or a tooth decay component as a tooth active ingredient, and comprises a water-soluble pressure-sensitive adhesive, a neutralizing agent, an emulsifier and a stabilizer. Patch Kit. 3. The dental patch kit of claim 2, wherein the whitening component is at least one selected from the group consisting of peroxides, metal chlorite, percarbonates, peroxides, and mixtures thereof. The dental patch kit according to claim 2, wherein the caries prevention component is at least one member selected from the group consisting of sodium fluoride, sodium monofluorophosphate, tin fluoride, calcium glycerophosphate, calcium lactate and mixtures thereof. . The method of claim 1, wherein the first water-soluble pressure-sensitive adhesive solution is (1) adding a water-soluble pressure-sensitive adhesive to a solvent, warming and stirring to uniformly dissolve, and then adding and mixing a neutralizing agent, an emulsifier and a stabilizer to the solution; And (2) a tooth patch kit comprising a step of adding a whitening component or a cavities prevention component to the mixture and stirring to stop the agitation, vacuum degassing and cooling when the mixture is uniform. The method of claim 5, wherein the first water-soluble pressure-sensitive adhesive solution is prepared by putting the solution prepared by the method of claim 5 in an opaque container and then covering the lid with a small discharge port and the lid attached to the brush Tooth patch kit. The patch of claim 1, wherein the patch including the water-soluble pressure-sensitive adhesive layer comprises an attachment site protective layer, an exposed area protective layer, and at least one water-soluble pressure-sensitive adhesive layer formed between the two layers. Kit. The dental patch kit according to claim 1, wherein the water-soluble pressure sensitive adhesive layer of the patch second agent contains a water-soluble pressure sensitive adhesive, a neutralizing agent, a crosslinking agent, an emulsifier, a decomposition accelerator, and a stabilizer. According to claim 1, The patch containing the water-soluble pressure-sensitive adhesive layer is as follows, (1) adding a water-soluble pressure-sensitive adhesive to the solvent, heating and stirring to dissolve uniformly, and then adding and mixing a neutralizing agent, an emulsifier, a decomposition promoter, and a stabilizer to the solution; (2) adding a crosslinking agent dispersed in purified water to the mixed solution and stirring to stop the stirring when the mixed solution is in a uniform state, and then vacuum degassing and cooling; (3) applying a uniform thickness of about 10 to 1000 μm to the protective layer of the attachment site on the film by using a coater, and then drying at room temperature by passing through a tunnel equipped with a blowing facility; And (4) Tooth patch kits, characterized in that prepared by including the step of laminating the exposed portion protective layer on the layer. The method of claim 1, wherein the first water-soluble pressure-sensitive adhesive solution contains a calcium source component as a tooth remineralization component, the patch second agent containing the water-soluble pressure-sensitive adhesive layer contains a personnel component as a tooth remineralization component Tooth patch kit. A tooth whitening, tooth decay prevention or remineralization method using a patch second agent comprising a water-soluble pressure-sensitive adhesive solution first agent and a water-soluble pressure-sensitive adhesive layer. 12. The tooth whitening, dental caries prevention or remineralization method of claim 11, wherein the first water-soluble adhesive solution is applied to the surface of the tooth using a brush, and the patch is applied with the patch second agent.