KR102089535B1 - Oral sealing wrap having extendable property - Google Patents

Abstract

The present invention includes a layer having a surface in contact with the tooth or the surrounding tissue of the tooth, and a film layer laminated on a layer having a surface in contact with the surrounding tissue of the tooth or the tooth and comprising a moisture-impermeable film layer. The layer having a surface in contact with the tissue is a hydrophilic polymer; And it provides a multi-layered oral sealing wrap, characterized in that any one selected from wetting agents, emulsifiers and mixtures thereof is a mixed membrane. The present invention can maintain excellent adhesion and adhesion even in the presence of moisture.

Description

Oral sealing wrap having extendable property

The present invention relates to a product for oral care, more specifically, when delivering drug components into the oral cavity (oral surface including teeth, gums and mucosal tissues), a new form capable of effectively delivering and further enhancing the efficacy of drug components It relates to products for oral care.

There are many different formulations for oral care and products for various usages, but because of the nature of the oral cavity, it is influenced by wet environment, authoring, and conversation. It is not easy to secure.

In addition to interest in tooth whitening, many studies have been conducted to improve oral health by delivering drugs between curved parts of teeth or between teeth and teeth. For example, studies for preventing or treating oral diseases such as gingivitis and periodontitis by delivering anti-inflammatory or antibacterial components into the soft tissues of the oral cavity have been made as part of this.

On the other hand, many people who are interested in whitening their teeth buy products directly from pharmacies or marts and products that can whiten teeth without the help of experts are on the market. It has the advantage of being able to whiten teeth without the help of a specialist and conveniently use them regardless of time or place.

However, as a disadvantage of tooth whitening products by non-experts, the problem of insufficient whitening effect has been raised. One of the causes is that the concentration of the whitening component delivered to the tooth surface is low, and the concentration of the low whitening component acts as a cause due to a wet environment in the oral cavity or contact with saliva.

In particular, by applying the drug in a variety of formulations, such as liquid, solid, and spray forms, to the target area of the teeth or gums in the oral cavity, the desired effect is obtained. Due to the nature of the oral cavity, it is always humid and physical such as speaking or chewing Due to the movement, the active ingredient did not stay in the target region until the desired contact time, so there was a tendency that the desired effect could not be obtained.

The inventors of the present invention need to secure sufficient contact time in order for the active ingredient to be effective in short-term use. However, even if the active ingredient is applied to the target in various formulations in a wet oral cavity, it is easily removed and washed, making it difficult to secure the desired contact time. Found. Particularly, since the oral cavity is a safety issue, it is difficult to use a high concentration or a large amount even if it is an active ingredient with excellent effect. Therefore, it has been realized that it is necessary to seal the active ingredient in order to achieve a desired effect in a short period of time with a small amount.

In addition, there is a problem that the whitening effect is not achieved until the tooth gap because the tooth whitening component is not transmitted to the gap between the teeth or the tooth. The reason for this problem is that commercial products have failed to develop a product that perfectly fits the individual tooth shape of the consumer, which allows the whitening component to be delivered to the tooth surface or the tooth gap.

International Publication No. WO 2004045569 A1 discloses a technique for uniformly producing the shape of a tooth patch in order to effectively whiten a tooth as a technique for whitening patches. However, these products have a problem that the effect may be different depending on the structure and shape of the user's teeth. For example, there was a problem that the product could not fully exhibit the efficacy of the product if the gap between the teeth was wider than the shape of the tooth designed in the product, or if the actual tooth was shorter or longer than the shape of the designed tooth.

In addition, these standardized tooth whitening patches inevitably require a thickness greater than a certain thickness to store the drug in order to deliver a certain amount of whitening agent effective for tooth whitening. Due to this thickness, the flexibility of the patch decreases and the teeth or uneven teeth are uneven. There was discomfort in the attachment.

On the other hand, in the case of peroxide, which is the most used as a tooth whitening component, there is a problem that the compatibility between the perfume component and the peroxide is poor, and the industry has been forced to use only the kind and amount of the perfume component used in the tooth whitening agent. However, even though the needs for taste and aroma are quite large in the oral products that directly taste, the industry has not provided a reasonable solution to this.

In the meantime, the industry has conducted numerous studies on systems for delivering drugs into the oral cavity, and in the meantime, product development has been actively conducted to satisfy the needs of consumers. Accordingly, the researchers of the present invention have completed the present invention as a result of steadily researching a system for delivering a drug into the oral cavity.

The problem to be achieved by the present invention is to develop a product such as a wrap for protecting an active ingredient applied over a tooth, especially in a mouth, from being washed out with saliva, such as a wrap used for storing food in a container for a long time.

The problem to be solved by the present invention is to enable the drug applied to a target site in the oral cavity to stay well for a desired time. We intend to develop a system for drug delivery that can minimize the effects of enzymes contained in saliva after the drug is applied to target sites in the oral cavity.

The present invention is to provide an oral wrap capable of maintaining adhesion and adhesion by completely wrapping the tooth surface and surrounding tissue after applying the composition in the form of a gel or paste.

The present invention is to provide a flexible oral wrap that can be easily removed when it is desired to remove it while being flexible and sealing the target area in the curved oral cavity due to strong adhesion due to moisture or saliva on the target, which does not get on the hand before attachment.

The present invention provides an oral sealing wrap for a new type of intraoral application that can seal a target region in the oral cavity, particularly a tooth and surrounding tissue, and has a lot of curvature.

One embodiment of the present invention includes a layer having a surface in contact with the tooth or the surrounding tissue of the tooth, and a film layer laminated on a layer having a surface in contact with the surrounding tissue of the tooth or comprising water-impermeable film layer. The layer having a surface in contact with the tooth or tissue surrounding the tooth is a hydrophilic polymer; And a wetting agent, an emulsifying agent, and a mixture of these, which is a mixed membrane.

The inventors of the present invention, unlike patch formulations such as oral patches for the delivery of active ingredients (e.g., teeth whitening ingredients), even areas of the oral cavity that have a lot of flexion and are difficult to apply, such as tooth and tooth gap, between teeth and gums, etc. As a result of long-term development of a new type of intraoral application product having excellent adhesion and adhesion, the present invention has been completed.

In addition, the inventors of the present invention have completed the present invention as a result of studying a product for the complete sealing of teeth, which was never thought in the industry.

In general, there are cases in which drugs are applied through not only the teeth but also tissues around the teeth for drug delivery through the oral cavity or drug delivery for intraoral application. In this case, the applied drug may cause problems such as dilution or washing of the drug by a special environment in the oral cavity (for example, a humid environment, physical obstruction by the tongue, etc.).

As one of the methods to solve this problem, a method capable of completely sealing the teeth and surrounding tissues has been considered, and a new type of oral delivery system has been developed.

One embodiment of the present invention includes a layer having a surface in contact with the tooth or the surrounding tissue of the tooth, and a film layer laminated on a layer having a surface in contact with the surrounding tissue of the tooth or comprising water-impermeable film layer. The layer having a surface in contact with the tooth or tissue surrounding the tooth is a hydrophilic polymer; And a wetting agent, an emulsifying agent, and a mixture of these, which is a mixed membrane.

The oral sealing wrap has a multi-layer structure including a membrane layer, which is a first layer that has adhesion while absorbing moisture while in contact with a tooth or surrounding tissue, and a film layer, which is laminated on the membrane and has a second layer having moisture impermeability. You can.

As used herein, 'tooth periphery' is a concept generally including a region represented by a gum, and may be used as a meaning including all mucosal regions of a tooth periphery. The periphery of the teeth may be used in a sense to encompass a site where the active ingredient can be delivered together or through the oral cavity when the oral composition is applied to the tooth. In the present specification, even if only described as 'tooth', it may be understood in the present specification to include all teeth or a peripheral portion of the tooth.

The tooth or the layer having a surface in contact with the tissue surrounding the tooth is a hydrophilic polymer; And a wetting agent, an emulsifying agent, and mixtures thereof.

As used herein, 'membrane' is a term that can be used instead of a barrier, a membrane, etc., and can be understood to mean a thin layer structure. The membrane has no adhesive strength before contact with moisture, but exhibits adhesive strength in contact with moisture, and may have sagging properties.

The membrane may include a hydrophilic polymer, and the hydrophilic polymer may preferably be a hydrophilic glassy polymer. The hydrophilic glassy polymer is, for example, polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer; Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, acrylate copolymer (Eudragit L- 100, Eudragit L-100, 55), Poloxamer 407 (Pluronic), Polyethylene oxide (polyox), Polyvinylpyrrolidone-vinyl acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP, K-15 ~ K-120), crosslinked PVP (crospovidone), polyquaternium-11 (Gafquat 755N), polyquaternium-39 (Polyquaternium-39; Merquat plus 3330), Carbomer (Carbopol), Hydroxypropylmethyl Cellulose, Hydroxyethyl Cellulose, Hydroxypropyl Cellulose, Methyl Cellulose, Carboxymethyl Cellulose, Gelatin, Sodium alginate, carrageenan, hyaluronic acid, It may be selected from gellan gum, pullulan or a mixture thereof, more preferably for the purposes of the present invention, polyvinylpyrrolidone, polyvinyl alcohol, polyalkylvinylether-maleic acid copolymer, Hydroxypropylmethylcellulose, hydroxypropylcellulose, or mixtures thereof can be used.

The hydrophilic polymer may be included 10 to 35% by weight based on the total weight of the membrane, preferably 15 to 30% by weight. It can provide excellent adhesion of the membrane in the above content range.

The wetting agent included in the membrane may be any one selected from polypropylene glycol, glycerin, polyethylene glycol, sorbitol, castor oil or mixtures thereof.

Oral sealing wrap according to an embodiment of the present invention may include a process of drying in the process of manufacturing the membrane. The membrane included in the sealing wrap can be over-dried due to its thin thickness, and even if it is not over-dried, the water-impermeable layer and phase separation may occur if the drying loss is too low due to natural drying during storage. Accordingly, the wetting agent may contain 2% by weight or more, preferably 2.5% by weight or more, and most preferably 5% by weight or more and 15% by weight or less with respect to the dry weight of the membrane.

In one embodiment, the loss on drying of the membrane is desirably 5% or more when dried for 10 minutes at 105 ° C as measured by a Mettler Toledo HX-204 Moisture Analyzer.

The emulsifier can be used without limitation as long as it is an emulsifier that can be used in oral products, and the emulsifier is Span 20 (sorbitan monolaurate), Span 40 (Span 40, sorbitan monopalmitate), Span 60 (Span 60, sorbitan monostearate), Span 80, sorbitan monooleate, Span 85, sorbitan trioleate, Tween, POE sorbitan fatty acid ester, polyethylene glycol, polyethylene oxide, disodium laureth sulfosuccinate, cocobetaine , Decylglycoside, babasumidopropylbetaine, cocamidopropylbetaine, twin 20, twin 40, twin 60, twin 80 or mixtures thereof. Preferably, an emulsifier having an HLB value of 10 or less can be used, for example, Span20, Span40, Span60, Span80, Span83, and the like. The emulsifier may include 2 to 15% by weight, preferably 2.5 to 10% by weight based on the total weight of the membrane.

As used herein, 'oral use' means that the drug can be delivered through the oral cavity, which means that it can be used not only when applied directly to a tooth, but also to tissues around the tooth, such as gums that come into contact with the tooth. You can.

'Sealing wrap' used in the present specification is a formulation newly introduced by the inventor through the present invention, and may mean a thin film-like formulation having sufficient flexibility and extensibility to wind a desired target site.

The membrane does not contain an active ingredient, and may include an auxiliary ingredient that can help to achieve the desired effect of the active ingredient.

The auxiliary component that can help to achieve the desired effect of the active ingredient is a component that can maximize the effect of the active ingredient even if a small amount is used, for example, a typical catalyst may be included.

As a specific example, the tooth whitening effect may be increased by attaching the sealing wrap of the present invention containing a fruit tree stabilizer and / or a tree fruit catalyst to a portion where the tooth whitening component is applied. Another example is the antimicrobial agent

The term 'active ingredient' used in the present specification is used in the same sense as a drug or a pharmaceutical ingredient, and may mean, for example, a main ingredient showing a tooth whitening effect and a main ingredient showing an oral disease prevention or treatment effect.

Patch products containing an active ingredient, such as a tooth whitening patch, had a problem of maintaining a certain thickness or more because a certain amount of an active ingredient had to be supported. In addition, there was a problem in that the adhesion was very poor due to the thick thickness.

However, the oral wrap comprising the membrane of the present invention can be made very thin because the type and content of the components included in the membrane are small.

The oral wrap of the present invention includes a moisture impermeable film layer provided by being laminated on the membrane. The moisture impermeable film layer may be polyethylene, polyurethane, or polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer, or mixtures thereof.

The moisture-impermeable film layer may preferably be polyethylene. The polyethylene has better human safety than other films, is economical, has high elongation, is not easily torn (excellent in tensile strength), and unlike other moisture impermeable materials, adhesion to the membrane comprising a hydrophilic glassy polymer It is easy to use particularly advantageously in the thin multi-layered wrap of the present invention.

The polyethylene may be preferably low density polyethylene (LDPE (Low Density Polyethylene)).

The oral sealing wrap used in the present specification has an elongation in terms of intraoral application, but provides properties to the teeth and requires properties that can be securely fixed.

In addition, the sealing wrap of the present invention requires a specific tensile force in consideration of both physical obstacles (for example, friction with the tip of the tongue or food), humidity, and the like in order to apply under special conditions such as oral cavity.

The sealing wrap of the present invention may have a tensile strength measured by a Zwick 1120 tensile testing machine of 0.1 kgf (0.98 N) to 2.0 kgf (19.6 N), and preferably 0.15 to 1 kgf.

When having the tensile strength, while having a stretch enough to be easily attached to the tooth surface, it is possible to minimize the phenomenon that the wrap is peeled or struck.

The membrane according to an embodiment of the present invention may have an adhesive strength of 50 gmf to 300 gmf, preferably 70 to 300 gmf.

The adhesion can be measured at 25 ℃ room temperature.

The adhesive force of the membrane can be measured by MTT175 Miniature Tensile Tester, and can be measured by measuring the adhesive force of products in the form of sheet and film in the industry.

The sealing wrap according to an embodiment of the present invention may have a thickness of 100 μm or less, preferably 80 μm or less, more preferably 50 μm or less, and most preferably 1 μm or more and 45 μm or less.

The thickness may be measured by a micrometer that measures the thickness in the industry, for example, using a Mitutoyo Micrometer (Mitsutoyo Micrometer).

It is possible to maintain flexibility while minimizing foreign feeling in the above range.

Another embodiment of the present invention, the oral sealing wrap of the multilayer structure; And a composition for tooth whitening or oral disease treatment or prevention, comprising a composition for tooth whitening or oral disease treatment or prevention, which is delivered to a tooth or tissue surrounding the tooth, and provides a kit for delivering drugs to the oral cavity. .

The composition for tooth whitening or oral disease treatment or prevention may be applied to one surface of the multi-layered oral sealing wrap and delivered to the tooth or tissue surrounding the tooth.

In another embodiment, the composition for tooth whitening or oral disease treatment or prevention is applied to a tooth or tissue surrounding the tooth, and the oral sealing wrap may be applied thereon, and is not necessarily limited to being applied to the sealing wrap. No, any type of delivery can be achieved using the kit, provided that both the sealing wrap and the composition are provided in the oral cavity.

Preferably, the composition may include a composition for whitening teeth, and the composition for whitening teeth includes a tooth whitening component, and the tooth whitening component includes hydrogen peroxide, carbamide peroxide, and calcium peroxide. peroxide, perborate, percarbonate, peroxyacids, persulfate, calcium chlorite, barium chlorite, magnesium chlorite ), Lithium chlorite, sodium chlorite, or a mixture thereof. Any component used for whitening teeth in the industry can be used without limitation and must be interpreted as being limited to the above components. Does not.

The active ingredient for the treatment or prevention of oral disease may be dry mouth, bad breath removal, gingivitis and periodontitis, or a tooth decay treatment or prevention ingredient, and any ingredient used to prevent or treat diseases in the oral cavity in the industry may be used without limitation. .

For example, trilosan, chlorhexidine, alexidine, hexetidine, sanguinarine, benzalkonium chloride, salicylanilide, bromide bromide Antimicrobial agents including pen (domiphen bromide), cetylpyridinium chloride (CPC), tetradecylpyridinium chloride (TPC), or mixtures thereof; Anti-inflammatory agents including aspirin, ketorolac, flurbiprofen, piroxicam, meclofenamic acid, or mixtures thereof; Or thiamine, riboflavin, nicotinic acid, pantothenic acid, pyridoxine, biotin, folic acid, vitamin B12, vitamin B12, lipoic acid ), Ascorbic acid, vitamin A, vitamin D, vitamin E, vitamin K or mixtures thereof; Or mixtures thereof, but is not limited thereto. In addition, corn-unsaturated quantitative extract, peppermint extract, myrrh, ratania, chamomile, polycresolene, centella quantitative extract nutmeg extract, dexpanthenol, beta-sitosterol, acetyl salicylic acid (acetyl salicylic acid), or an effective drug for preventing and improving periodontal disease. Syringe containing zinc chloride, potassium phosphate, potassium diphosphate, calcium chloride, oxalic acid, potassium oxalate, ferric oxalate, vitamin E, etc. alone or two or more may include a symptomatic and alleviating component.

In the kit for oral drug delivery, a composition for tooth whitening or oral disease treatment or prevention comprising an effective ingredient for tooth whitening, or oral disease treatment or prevention, delivered to a tooth or tissue surrounding a tooth is a patch (drug Contains all formulations that are released to the attached site after storage and can be termed films, strips, etc.), all common formulations used to deliver drugs intraorally, such as gels, pastes, liquids, sprays or ointments. It may include, the formulation is not particularly limited.

An embodiment of the present invention provides a kit for whitening teeth comprising a multi-layered oral sealing wrap, and a composition for whitening teeth. The oral sealing wrap of the multilayer structure may further include a tooth whitening aid on a membrane in contact with the tooth.

The tooth whitening aid used in this specification is in itself insufficient to exhibit a tooth whitening effect, but may be understood to mean a component that enhances the whitening efficacy while being used together with the tooth whitening component.

For example, it may include a component that helps to improve the whitening effect of the tooth whitening component, may include a fragrance component for reducing the unpleasant taste of the tooth whitening component, the purpose of enhancing the stability of the tooth whitening component It may include components used as, and may include components used for the purpose of reducing irritation caused by tooth whitening components.

Specifically, the kit for whitening teeth may be provided by including a tooth whitening component exhibiting a tooth whitening effect in a multi-layered oral sealing wrap, and included in a separate composition for whitening teeth. The separate composition for whitening teeth is a patch (i.e., includes all formulations that store the drug and then release it to the attached site, and may be referred to as a film, strip, etc.), gel, paste, liquid, spray or ointment. And the like.

The kit for whitening teeth provided in one embodiment of the present invention can be provided with a very thin thickness because it can be provided without including the whitening efficacy component in the oral sealing wrap of the multilayer structure. The composition for whitening teeth contained in the kit for whitening teeth may preferably include a peroxide as a whitening efficacy component exhibiting whitening efficacy.

The tooth whitening aid included in the membrane in contact with the tooth may be provided alone or by mixing any one or more selected from pH adjusting agents, peroxide catalysts, photocatalysts, peroxide stabilizers, and mixtures thereof.

The pH adjusting agent may react with peroxide to generate a perhydroxy radical to enhance the tooth whitening effect, for example, sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, citric acid Sodium, and one or more selected from the group consisting of EDTA-4Na may be used, but is not limited thereto. The pH adjusting agent may be used in an appropriate amount such that the pH of the composition is 8-11.

The peroxide catalyst is a component capable of promoting the decomposition of peroxide, for example, selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, manganese sulfate, manganese gluconate, manganese chloride and manganese citrate. One or more types may be used, but the present invention is not limited thereto.

The photocatalyst may be titanium dioxide (TiO ₂ ) or the like, but is not limited thereto.

The condensed phosphate may be used as the condensation phosphate, and usable condensed phosphates include sodium pyrophosphate (TSPP), sodium acid pyrophosphate (SAPP), and sodium polypolyphosphate (STP). , One or two or more of sodium potassium pyrophosphate, tetrapotassium pyrophosphate, acidic sodium metaphosphate, and acidic sodium polyphosphate may be used. .

The oral sealing wrap of the multi-layer structure may further include fragrance, gum protection components, etc., on the membrane contacting the teeth as a tooth whitening aid.

The scent that may be included in the sealing wrap may be used without limitation, the scent used in products for oral care in general, for example, as a material used in fragrances and food fragrances, peppermint oil, menthol, spearmint Oil, carbon, anise oil, anitol, eucalyptus oil, clove oil, eugenol, winter green oil, methyl salicylate, cinnamon oil, cinnamic aldehyde, and the like may be included.

The gum protective component is a component capable of alleviating irritation caused by the tooth whitening component, for example, amino acids including methionine, cysteine and taurine; Organic acids including ursodeoxycholic acid and tauroursodeoxycholic acid; And it may include one or more oral irritation-reducing components selected from the group consisting of vitamins containing vitamins A, C, and E, preferably amino acids containing methionine, cysteine, and taurine.

The multi-layered oral sealing wrap enhances the tooth whitening efficacy of a tooth whitening composition containing a tooth whitening component (for example, hydrogen peroxide) rather than the tooth whitening effect itself, or the use of the tooth whitening composition It is possible to add ingredients that can improve convenience, improve the feeling of use of the composition for whitening teeth, and the like.

The tooth whitening aid may include 0.1 to 12% by weight, preferably 0.3 to 10% by weight based on the total weight of the membrane.

When including the above content range, the kit is advantageous to achieve the object of the present invention by making the thickness of the sealing wrap thin (100 μm or less) while improving the tooth whitening efficacy.

The present invention can protect the active ingredient applied in the oral cavity from being diluted in saliva, washed out, or physically removed by the tongue.

The present invention can allow the drug applied to the target site in the oral cavity to stay well for a desired time. After the drug is applied to the target site in the oral cavity, it is possible to provide a system for drug delivery that can minimize the effect of enzymes contained in saliva.

The present invention provides an oral wrap capable of maintaining adhesion and adhesion by completely wrapping the tooth surface and surrounding tissue after applying the composition in the form of a gel or paste.

The present invention provides a flexible oral wrap that can be easily removed when it is desired to be removed while sealing the target area in the curved oral cavity due to its strong adhesion due to moisture or saliva on the target, which is flexible but does not get on the hand before attachment.

Hereinafter, the following examples and the like will be described to more specifically describe the present invention. However, the embodiments according to the present invention can be modified in many different forms and the scope of the present invention should not be interpreted as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to assist in the detailed understanding of the present invention. Unless otherwise stated, the percentages described herein can be understood to mean weight percent.

[For oral Sealing Lab  Produce]

Sealing wraps for oral cavity having a two-layer structure of Examples and Comparative Examples having the following composition.

Example 1 Example 2 Example 3 Example 4 1 ^st Layer Glycerin 3.0%
PVP 21.0%
Flavor 2.0%
SPAN80 1.0%
Ethanol to 100% PEG 10.0%
PVA 20.0%
SPAN80 5.0%
Water to 100% Glycerin 3.0%
HPMC 10.0%
Gantrez 10.0%
SPAN80 3.0%
FeCl3 0.5%
NaOH pH to 10
Water to 100% Glycerin 8.0%
HPC 15.0%
Pullulan 3.0%
SPAN80 5.0%
Ethanol to 100% 2 ^nd Layer PE Film Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% Polyurethane Film PE Film Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 1 ^st Layer none none none Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% 2 ^nd Layer PE Film Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% Polyurethane Film PE Film

Physical properties were measured for Examples 1-4 and Comparative Examples 1-4.

[Check physical properties]

▶ The thickness of Example 1-4 was measured.

Thickness less than 100um: No foreign body feeling, and was not disturbed by daily life.

If the active ingredient is contained, it is difficult to make it thin because it affects the concentration and amount of the active ingredient, but this wrap can be made thin enough because its main purpose is wrapping.

▶ The adhesion strength before and after hydration of Example 1-4 was measured.

The adhesive force (adhesion force) to the teeth was measured using a miniature tensile tester. The adhesion to the teeth in the dry state was measured for the adhesion of the wrap to the completely dried hydroxyapatite tablet, and the adhesion after hydration was first applied to hydroxyapatite tablets with sufficient water to imitate the wet oral cavity. After adding, the excess moisture was removed using a tissue, and the adhesive strength of the wrap was measured after applying the second agent used together. The adhesive strength of the wrap to the teeth was measured by pressing the hydroxyapatite tablet with wrap for a certain period of time with a constant contact force, and then measuring the force applied while removing the wrap.

▶ The tensile strengths of Examples 1-4 and Comparative Examples were measured.

When you wrap it in the target area and remove it after it is used up, it is removed without tearing.

[ In use  About evaluation]

1. Characteristics of wrap for panels in the laboratory and Usability  Survey evaluation

Wrap was used for both the upper and lower 6 teeth and the lower and lower teeth 2 times using both the Examples and Comparative Examples, and then responded to stiffness, adhesion, and adhesion. The response was made on a 10-point scale, and the 10-point was the highest value. The panel evaluated 10 applicants regardless of age.

Initial adhesion Adhesion after hydration Initial strength Strength after hydration Example 1 2 10 6 2 Example 2 2 8 6 2 Example 3 2 8 5 2 Example 4 2 8 6 2 Comparative Example 1 2 2 6 6 Comparative Example 2 2 2 6 6 Comparative Example 3 2 2 5 5 Comparative Example 4 2 2 6 6

[Comparison of Efficacy Effects of Example of Use and Comparative Example of Use according to Method of Use]

Example 1
Spray + Wrap Example 2
Paste + Wrap Example 3
Gel + Wrap Example 4
Patch + Wrap Part 1: Bad breath spray
(Amway Gleester Mouse Spray)
2nd agent: Wrap (Example 1) Part 1: Paradontax
No. 2: Wrap (Example 2) Part 1: tooth whitening gel
(Median It's White Tooth White Gel)
No. 2: Wrap (Example 3) Article 1: Syringe Patch
(P & G Sensi-Stop)
No. 2: Wrap (Example 4)

Use Comparative Example 1 Spray only

Use Comparative Example 2 Paste only

Comparative Example 3 Gel only

Comparative Example 4 Strip Only

One) Usage Example 1 Comparison of use  1, consumer usability Removal of bad breath by evaluation and Refreshing  compare

2) Example 2 and Comparative Example 2  Comparison of gingivitis relief effect by consumer usability evaluation

3) Usage Example 3 Comparative Example 3  Comparison of teeth whitening effect by consumer usability evaluation

4) Example 4 Comparative Example 4  With consumer usability evaluation Sirin  Symptom relief effect comparison

<Panel evaluation>

1. Eliminate bad breath for panels in the laboratory Refreshing  Sustainability survey evaluation

1) Experimental object and usage : Use Example 1 and Use Comparative Example 1 do not drink water or drink or eat snacks 1 hour after meals 3 times a day, and spray the mouse as usual (Amway Gleester Mouse in this experiment) After using the spray), the use example 1 covered the six maxillary anterior teeth with the wrap of example 1, and the comparative example did not carry out separate treatment.

For the selection of the experiment panel, 10 volunteers were recruited for volunteers in their 20s in the institute, and after using Example 1 one day (three times) and using Comparative Example 1 one day (three times), satisfaction was surveyed according to the following scale. Did.

2) Satisfaction evaluation (5 points satisfaction for each question, 5 points very satisfied, 4 points satisfied, 3 points average, 2 points unsatisfactory, 1 point very unsatisfactory).

Convenience in use in the questionnaire is convenience for the method of use, and the feeling of use / wearing is satisfaction with the feeling of feeling when using each in the oral cavity, the feeling of foreign body or the feeling of smearing on the unwanted parts such as hands or lips or disappearing easily. Asked.

(Evaluation results)

Convenience of use Usability /
Fit Bad breath removal
effect Refreshing persistence Overall satisfaction Example 1 4 5 5 5 4.5 compare
Example 1 5 3 3.5 3 3

2. Survey on the effectiveness of gingivitis relief for panelists in the institute

1) Experimental object and usage : In the use example 2 and the use example 2, paradontax ointment was used in the area where gingivitis is felt when the symptoms of gingivitis are felt twice a day. In the use example 2, the ointment was covered with the wrap of example 2 as if wrapping the teeth and gums, and the comparative example 2 was not treated separately. The same method was used for one month.

For the selection of the experiment panel, 10 volunteers were recruited for 50 volunteers in the institute, and after using Example 1 for one day (three times) and using Comparative Example 1 for one day (three times), satisfaction was surveyed according to the following scale. Did.

2) Satisfaction evaluation (5 points satisfaction for each question item, 5 points very satisfied, 4 points satisfied, 3 points average, 2 points unsatisfactory, 1 point very unsatisfactory)

The ease of use in the questionnaire is convenience for the method of use, and the feeling of use / wearing is the feeling, feeling of adhesion when using each in the oral cavity, the feeling of smearing on the unwanted parts such as foreign body or hands or lips, or disappearing easily. Asked about overall satisfaction.

(Evaluation results)

Convenience of use Usability / wearing Gingivitis relief effect Overall satisfaction Example 2 4.5 5 5 4.5 compare
Example 2 3.5 2.5 3 3

3. Questionnaire evaluation of whitening effect on teeth in panel in the institute

1) Experimental object and usage : In Example 3 and Comparative Example 3, whitening gel was used in 6 of the upper teeth anterior teeth twice a day in the morning and in the afternoon for 30 minutes. The use example 3 was wrapped with the wrap of example 3 as if the teeth and gums were wrapped on the area where the whitening agent was applied, and the use comparison example 3 was not treated separately. The same method was used for one month.

For the selection of the experiment panel, 10 volunteers were recruited for volunteers in their 30s in the institute, and 5 used only Example 3 and 5 used Comparative Example 3, and the satisfaction was surveyed according to the following scale.

2) Satisfaction evaluation (5 points satisfaction for each question item, 5 points very satisfied, 4 points satisfied, 3 points average, 2 points unsatisfactory, 1 point very unsatisfactory)

Convenience in use in the questionnaire is convenience for the method of use, and the feeling of use / wearing is a feeling of feeling, adhesion, foreign body feeling or a feeling of smearing or disappearing easily on unwanted parts such as hands, lips, etc. Asked about overall satisfaction.

(Evaluation results)

Convenience of use Usability / wearing Feeling brightened teeth (whitening) Overall satisfaction Example 3 4 5 5 5 compare
Example 3 5 2 3 3

4. For panels in the institute Sirin  Mitigation effect questionnaire evaluation

1) Experimental object and usage : Use Example 4 and Use Comparative Example 4 were used once a day for 10 minutes in the area where the person feels symptoms. In Example 4, P &G's SensiStop syringe was attached to the strip, and then Example 4 wrap was used to wrap the teeth and gums on the correct area where the strip was attached, and Comparative Example 2 was not treated separately. The same method was used for one month.

For the selection of the experiment panel, 10 volunteers were recruited for 50 volunteers in the research institute, 5 of them used only 4 use cases 3 times, 5 of them used 4,3 times of comparative use cases, and then satisfied with the following scale. Survey was conducted.

2) Satisfaction evaluation (5 points satisfaction for each question item, 5 points very satisfied, 4 points satisfied, 3 points average, 2 points unsatisfactory, 1 point very unsatisfactory)

The ease of use in the questionnaire is convenience for the method of use, and the feeling of use / wearing is the feeling, feeling of adhesion when using each in the oral cavity, the feeling of smearing on the unwanted parts such as foreign body or hands or lips, or disappearing easily. Asked about overall satisfaction.

(Evaluation results)

Convenience of use Usability / wearing The symptoms of the pain relief Overall satisfaction Example 4 3 5 5 5 compare
Example 4 4 2 3 3

[Application example]

1. Flavor Long-Lasting function :

As it is manufactured in a multi-layer structure, unlike general wraps, you can also add the desired flavor, pattern, and color. In particular, chewing gum, spraying spray or using gargle for the purpose of improving bad breath in the oral cavity, but the moment of using the product is refreshing, but there is a problem that it is restored to its original state soon. If you do it, the flavor is released continuously, and it may give you the refreshing feeling of chewing gum.

2. Whitening effect synergistic function: It is difficult to use together because peroxide and compatibility are poor, but it is difficult due to stability problem. Can be obtained.

3. Add cosmetic function: It provides the effect of adding cosmetic function while attaching it by wrapping the desired pattern or pattern into the wrap.

Claims (20)

A layer having a surface in contact with a tooth or tissue surrounding the tooth,
It is laminated on a layer having a surface in contact with the tooth or the tissue surrounding the tooth and includes a moisture impermeable film layer,
The tooth or a layer having a surface in contact with the tissue surrounding the tooth is a hydrophilic polymer; And a wetting agent, an emulsifier and any one selected from a mixture thereof, characterized in that the mixed membrane, oral sealing wrap of a multi-layer structure,
The oral sealing wrap does not contain an effective ingredient for tooth whitening or oral disease treatment or prevention, a multi-layered oral sealing wrap. The method of claim 1, wherein the hydrophilic polymer is polyalkyl vinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, acrylate copolymer, poloxamer, polyethylene oxide, polyvinylpyrrolidone-vinyl acetate copolymer, polyvinyl Pyrrolidone, crospovidone, polyquaternium, carbomer, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, carboxymethylcellulose, gelatin, sodium alginate, carrageenan, hyaluronic acid, Multi-layered oral sealing wrap, characterized in that any one selected from the group consisting of gellan gum, pullulan and mixtures thereof. According to claim 1, wherein the oral sealing wrap of the multilayer structure is characterized in that the adhesive strength of 50 gmf to 300 gmf measured by MTT175 Miniature Tensile Tester at room temperature 25 ℃, oral sealing wrap of a multilayer structure. According to claim 1, wherein the wetting agent is polypropylene glycol, glycerin, polyethylene glycol, sorbitol, castor oil and any one selected from the group consisting of mixtures, oral sealing wrap of a multi-layer structure. The method of claim 1, wherein the membrane comprises 2 to 15% by weight based on the total dry weight of the wetting agent, and when dried for 10 minutes at 105 ℃, characterized in that the drying loss of the membrane is 5% or more, oral cavity of a multi-layer structure Sealing wrap. The method according to claim 1, wherein the emulsifier is span 20, span 40, span 60, span 80, span 85, twin-based, polyethylene glycol, polyethylene oxide, disodium laureth sulfosuccinate, cocobetaine, decyl glycoside. , Baba suamidopropyl betaine, cocamidopropyl betaine, tween 20, tween 40, tween 60, tween 80 and mixtures thereof. The oral cavity of claim 1, wherein the oral sealing wrap has a tensile strength of 0.1 kgf (0.98 N) to 2.0 kgf (19.6 N) measured by a Zwick 1120 tensile testing machine. Sealing wrap. delete The method of claim 1, wherein the material of the moisture impermeable film layer is polyethylene, polyurethane, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer, and these Characterized in that any one selected from the group consisting of a mixture, oral sealing wrap of a multi-layer structure. The oral sealing wrap of claim 9, wherein the moisture-impermeable film layer is polyethylene. According to claim 1, The oral sealing wrap of the multilayer structure is characterized in that it has a thickness of 100㎛ or less, the oral sealing wrap of the multilayer structure. Claim 1 to claim 7 and claim 9 to claim 11 of any one of the tooth whitening or oral disease treatment or prevention of the active ingredient does not contain a multi-layered oral sealing wrap; And
A composition for tooth whitening or oral disease treatment or prevention comprising an effective ingredient for tooth whitening or oral disease treatment or prevention, which is one or more formulations selected from formulations consisting of gel, paste, liquid, spray, and ointment,
The tooth whitening or oral disease treatment or prevention composition is applied to the tooth or tissue surrounding the tooth, the oral sealing wrap of the multilayer structure is applied, oral drug delivery kit. The method of claim 12, wherein the tooth whitening efficacy component, the tooth whitening component hydrogen peroxide, urea peroxide, calcium peroxide, perborate, percarbonate, peroxy acid, persulfate, calcium chlorite, barium chlorite, Kit for oral drug delivery, characterized in that any one selected from the group consisting of magnesium chlorite, lithium chlorite, sodium chlorite and mixtures thereof. The kit for oral drug delivery according to claim 12, wherein the active ingredient for treating or preventing oral disease is a component for treating or preventing dry mouth, bad breath, gingivitis and periodontitis, or caries. delete Claim 1 to claim 7 and claim 9 to claim 11, wherein the oral sealing wrap of a multi-layer structure that does not contain the active ingredient for teeth whitening; And
It includes a composition for whitening teeth, which is one or more formulations selected from formulations consisting of gel, paste, liquid, spray, and ointment,
Oral sealing wrap of the multi-layer structure, characterized in that it further comprises a tooth whitening aid on the membrane in contact with the tooth, after applying the composition for tooth whitening to the tooth oral sealing wrap of the multilayer structure is a kit for tooth whitening. The kit for tooth whitening according to claim 16, wherein the tooth whitening aid is used alone or in combination with one or more selected from pH adjusting agents, peroxide catalysts, photocatalysts, peroxide stabilizers, and mixtures thereof. The method of claim 17, wherein the pH adjusting agent is at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, and EDTA-4Na,
The peroxide catalyst is at least one selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate, manganese gluconate, manganese gluconate, manganese chloride and manganese citrate,
The photocatalyst is titanium dioxide,
The peroxide stabilizer is at least one selected from the group consisting of sodium pyrophosphate, sodium pyrophosphate, sodium polyphosphate, potassium pyrophosphate, potassium pyrophosphate, acidic metapolyphosphate, and acidic polyphosphate. , Kit for whitening teeth. The method of claim 16, wherein the oral sealing wrap of the multilayer structure is characterized in that it further comprises a flavoring agent, gum protection component on the membrane in contact with the teeth, kit for whitening teeth. Applying a composition for whitening teeth, which is at least one formulation selected from a formulation consisting of a gel, a paste, a liquid, a spray, and an ointment; And
Claim 1 to claim 7 and claim 9 to claim 11 of any one of any one of the tooth whitening effect of the oral sealing wrap, which does not contain the active ingredient for tooth whitening, applied to the tooth coated with the composition for teeth whitening teeth Comprising the steps of, whitening teeth.