KR20160097793A - Reservoir-type patch for tooth whitening - Google Patents

Abstract

The present invention provides a reservoir-type patch for tooth whitening comprising: an adhesive layer which is bonded to teeth; and a reservoir which contacts a portion of the surface of the adhesive layer bonded to the teeth and is capable of impregnating a liquid preparation or a gel preparation, wherein separate tooth whitening components of the liquid preparation or the gel preparation are injected into the reservoir. A reservoir-type patch for tooth whitening according to the present invention minimizes a drop in contents of the efficacy components during a period of using the product by improving long term stability of tooth whitening efficacy components before using the product. Further, a reservoir-type patch for tooth whitening according to the present invention is capable of obtaining fast and effective tooth whitening effects by improving activities of the tooth whitening efficacy components when using the product, thereby prompting decomposition of the tooth whitening efficacy components.

Description

RESERVOIR-TYPE PATCH FOR TOOTH WHITENING BACKGROUND OF THE INVENTION [0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a patch for tooth whitening of a reservoir type, and more particularly to a reservoir type tooth whitening patch which is injected with a liquid whitening ingredient for a liquid or a gel into a reservoir capable of impregnating a liquid or gel.

In recent years, there has been a growing interest in dental care for cosmetic purposes, and in particular, white and bright teeth are regarded as important elements of beauty. In addition to professional tooth whitening procedures in dentistry, interest in tooth whitening products for self-care that can be easily purchased in the market is greatly increasing, and various products are already on the market. Typical products include toothpastes containing hydrogen peroxide or its precursor carbamide peroxide, wet patches, dry patches, and trays combined with products.

In general, the esthetics of teeth are influenced by the arrangement, size, color, texture and light transmittance of teeth, especially the color of tooth is a very important factor. The yellow discolored tooth is not only esthetically but also self-confidence And the importance of tooth whitening is increasing.

Teeth are yellowed as the compounds, such as tannins or polyphenols, that are contained in various foods we eat, penetrate into the tooth surface, enamel or dentin and become colored. It can be removed simply by brushing teeth or other physical methods on the surface of the teeth, but the coloring materials penetrating into the enamel and dentin are not easily removed and the teeth can be returned to white and bright teeth using dental whitening or whitening products. have. In other words, teeth whitening refers to a method of improving the color of enamel and dentin that is discolored or colored by using the action of whitening component to white and transparent color.

Hydroxy peroxide and carbamide peroxide are mainly used as effective ingredients for tooth whitening. These active ingredients are decomposed under various conditions to generate free radicals. These free radicals are attached to the teeth, It is known that tooth whitening is achieved by changing the colored chromophore in a colorless manner by combining. Hydrogen peroxide, which exhibits teeth whitening effect, should be decomposed into free radicals to exhibit tooth whitening effects. Components such as hydrogen peroxide and carbamide peroxide decompose hydrogen peroxide by temperature, pH, metal ions, and light, thereby promoting free radical generation It is known.

However, in the case of a tooth whitening agent for private use, since the content of hydrogen peroxide must be maintained above a certain level for about two years or more during commercial use in order to have commerciality as a product, commercialization is focused on stabilization rather than decomposition. In other words, it was necessary to develop a product having excellent effect that the tooth whitening effect substance of hydrogen peroxide is stable in the tooth whitening formulation and promotes the formation of free radicals through a rapid decomposition process in use.

As interest in cosmetic tooth whitening has increased, various self-service tooth whitening products that can be directly used by consumers are on the market. Among them, toothpaste, gel formulation, and patch formulation, which are relatively convenient to use, are attracting attention from consumers. However, in case of toothpaste, whitening effect is not significant due to short contact time even though it contains an ingredient having excellent whitening effect, and it is advantageous to use even in the case of gel formulation, but it is not easy to taste masking, But the tooth whitening effect is not satisfactory because it is easily washed away by the saliva and the like. In the case of the patch formulation, the contact time of the tooth is increased more than the tooth preparation or the gel formulation. However, it is difficult to contain a large amount of the whitening ingredient in the manufacturing process, and an improvement is needed to obtain a quick effect in contact with the tooth.

The currently developed tooth whitening patch is the one with the highest sales in the market due to the dry feeling of the single-layer patch which is good in feel and has a relatively high efficacy. However, it is not easy to increase the content of the main ingredient due to difficulties in the manufacturing process, and the diffusion rate of the main ingredient to the tooth surface is slower than that of the liquid or gel formulation, so it is necessary to improve the efficacy.

Korean Patent Publication No. 2002-0001620

It is an object of the present invention to provide a reservoir-type tooth whitening patch, which can be used by attaching a separate liquid or gel-forming component for teeth whitening to the reservoir and attaching it to teeth.

In order to solve the above-mentioned problems, the present invention provides a pressure-sensitive adhesive sheet, And a reservoir capable of impregnating a liquid agent or a gel agent and contacting a part of the surface of the adhesive layer adhered to the teeth, wherein a reservoir type tooth whitening agent for injecting a separate liquid or gelling agent for tooth whitening into the reservoir Provide patches.

In one embodiment of the present invention, the surface of the adhesive layer adhered to the tooth may be protected by a release paper.

In one embodiment of the present invention, the tooth whitening component may include hydrogen peroxide.

In one embodiment of the present invention, the tooth whitening component may further comprise at least one member selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, and sodium carboxymethyl cellulose.

In one embodiment of the present invention, the tooth whitening component may further comprise a stabilizer.

In one embodiment of the present invention, the stabilizer may be at least one selected from the group consisting of sodium stannate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite.

In one embodiment of the present invention, the tooth whitening component may be in the form of a liquid or a gel, having a viscosity of 100 to 10,000 cps.

In one embodiment of the present invention, the reservoir may be at least one selected from the group consisting of natural or synthetic nonwovens, natural or synthetic wovens, hydrophilic modified fibers of natural or synthetic nonwovens, and urethane based foams.

In one embodiment of the present invention, the reservoir may be impregnated with 1 to 30 times the weight of the reservoir itself.

In one embodiment of the present invention, the reservoir may be 0.01 to 5 mm thick.

In one embodiment of the present invention, the reservoir may further comprise a hydrogen peroxide activator.

In one embodiment of the present invention, the hydrogen peroxide activator may be at least one selected from the group consisting of sodium hydroxide, sodium bicarbonate, and sodium percarbonate.

In one embodiment of the present invention, the adhesive layer may be composed of at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer.

In one embodiment of the present invention, the adhesive layer comprises at least one of cellulose gum, hydroxypropyl methylcellulose, hydroxyethylcellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, An acrylate copolymer comprising an acrylate monomer, an aminomethacrylic copolymer, a methacrylic acid ethyl acrylate copolymer, sodium polyacrylate, and acrylic acid as a monomer.

In one embodiment of the present invention, the adhesive layer may further comprise at least one selected from the group consisting of glycerin, butylene glycol, and ethylene glycol.

In an embodiment of the present invention, the adhesive layer may have a thickness of 10 to 500 mu m.

In an embodiment of the present invention, the adhesive layer may further comprise a support.

In one embodiment of the present invention, the support may be at least one film selected from the group consisting of polyethylene, polyester, polypropylene, urethane and ethylene vinyl acetate.

The present invention also provides a tooth whitening method using the tooth whitening patch.

In one embodiment of the present invention, the tooth whitening method may include injecting the tooth whitening ingredient of the separate liquid or gel into the reservoir, and attaching the adhesive layer to the tooth.

According to the reservoir-type tooth whitening patch of the present invention, it is possible to improve the long-term stability of the tooth whitening effective ingredient before use, thereby minimizing the decrease in the content of the effective ingredient during the use period of the product and improve the activity of the tooth whitening effective ingredient So that a quick and effective tooth whitening effect can be obtained. In addition, since the teeth whitening ingredient of the liquid or gel is advantageous in that the diffusion speed is fast to the tooth surface, the tooth whitening effect ingredient of the liquid or gel is impregnated into the reservoir of the patch to attach the patch to the tooth, It is possible to minimize the loss of tooth whitening efficacious ingredient and to relieve irritation to teeth and gums, so that the feeling is excellent.

Hereinafter, preferred embodiments of the present invention will be described in detail in order to facilitate the present invention by those skilled in the art.

The present invention relates to an adhesive layer to be attached to teeth; And a reservoir capable of impregnating a liquid agent or a gel agent and contacting a part of the surface of the adhesive layer adhered to the teeth, wherein a reservoir type tooth whitening agent for injecting a separate liquid or gelling agent for tooth whitening into the reservoir Provide patches.

The reservoir-type tooth whitening patch according to the present invention is characterized in that a reservoir (storage layer) capable of impregnating a liquid agent or a gel agent is in contact with a pressure-sensitive adhesive layer capable of attaching teeth, and when the reservoir is used, (Loading) the ingredients. In the present invention, the reservoir is also referred to as a reservoir.

The reservoir may be provided between the tooth and the adhesive layer, and the adhesive layer is preferably a little larger than the storage tank so that it can be attached to the tooth. That is, a reservoir having a size smaller than that of the adhesive tank is attached on the surface of the adhesive layer that is attached to the teeth.

In the present invention, the surface of the adhesive layer to be adhered to the teeth may be protected by a releasing paper or a releasing film, and it is preferable to remove the releasing paper or the releasing film during use. That is, a reservoir tank having a size smaller than that of the adhesive tank is attached on the surface of the adhesive layer, and the entire surface of the adhesive layer including the storage tank is covered with a release sheet or a release film to protect the surface.

The release or release film protects the patch from contamination and damage of the patch before use. The releasing paper or release film is not particularly limited, but may be a polyethylene terephthalate or polypropylene film and may be coated with silicon or Teflon on one side to facilitate removal during use of the patch.

In the present invention, the storage tank is not particularly limited as long as it is made of a material capable of impregnating a liquid or a gel. Preferably, the reservoir may be one or more selected from the group consisting of natural or synthetic nonwovens, natural or synthetic wovens, natural or synthetic nonwovens, hydrophilic modified fibers and urethane based foams.

The storage tank may be impregnated with 1 to 30 times, preferably 1 to 10 times as much liquid or gel as the weight of the storage tank itself.

The reservoir may be a layer having a thickness of 0.01 to 5 mm. When the thickness is less than 0.01 mm, the impregnation amount of the hydrogen peroxide content is too small, and the whitening effect is low. When the thickness is more than 5 mm, the foreign matter is large when adhered to the teeth.

In the present invention, the reservoir may further comprise a hydrogen peroxide activator.

As described above, the tooth whitening component may further include a stabilizer. The stabilizer may improve the stability of hydrogen peroxide during the distribution period of the patch. However, when adhered to the teeth during use, the hydrogen peroxide decomposes, Considering the mechanism of whitening, the activity of hydrogen peroxide can be reduced and it can act as a negative factor. Therefore, it is preferable to further include a hydrogen peroxide activator capable of promoting the whitening action of stabilized hydrogen peroxide in order to obtain an optimum whitening effect during use. In addition, the liquid or gel formulations are highly flowable and have a relatively high possibility of causing irritation to the teeth or gums. It reacts with the hydrogen peroxide activator in the reservoir to lower the acidity of the tooth whitening ingredient of the liquid or gel, Neutralization may alleviate the stimulation, which may accelerate the decomposition of hydrogen peroxide and increase free radical generation.

The hydrogen peroxide activator may be at least one selected from the group consisting of sodium hydroxide, sodium bicarbonate, and sodium percarbonate.

The hydrogen peroxide activator is preferably 0.01 to 5% by weight based on the total weight of the storage tank. If the amount is less than 0.01% by weight, the effect of the activating agent is insufficient. If the amount is more than 5% by weight, it may be activated too quickly or irritate the teeth or gums.

In the present invention, the adhesive layer is a layer which is in contact with the reservoir on one side and adheres to the teeth on the other side. If the adhesive layer is made of a material capable of adhering to the tooth due to adhesive force when it comes into contact with the moisture of the tooth, It is not.

The adhesive layer may be prepared, for example, by dissolving a pressure-sensitive adhesive layer composition in a solvent such as water or ethanol, and then coating and drying the moisture-impermeable film as a support.

Preferably, the adhesive layer may be composed of at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer. Specifically, the pressure-sensitive adhesive layer may be formed of at least one selected from the group consisting of celluloses, hydroxypropylmethylcellulose, hydroxyethylcellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, An acrylate copolymer comprising a polymer, a methacrylic acid ethyl acrylate copolymer, sodium polyacrylate, and acrylic acid as a monomer.

The hydrophilic polymer may further include a plasticizer based on a hydrophilic polymer. The plasticizer may be at least one selected from the group consisting of glycerin, butylene glycol, propylene glycol, dipropylene glycol, pentylene glycol, sorbitol and ethylene glycol. For example, the hydrophilic polymer may be selected from the group consisting of cellulose gels, hydroxypropylmethylcellulose, hydroxyethylcellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, aminomethacryl A methacrylic acid ethyl acrylate copolymer, an acrylate copolymer containing sodium polyacrylate and acrylic acid as monomers, and the like.

In addition, the crosslinkable water-soluble polymer may further include a plasticizer and / or a crosslinking agent with a water-soluble polymer capable of crosslinking as a main chain. The plasticizer is as described above, and the cross-linking agent may be at least one of aluminum glycinate and aluminum hydroxide. For example, the crosslinkable water-soluble polymer may be at least one of polyacrylic acid, sodium polyacrylate, and an acrylate copolymer using acrylic acid as a monomer. In particular, the crosslinked adhesive layer is advantageous in that it can be adhered for a long time as compared with a tooth adhesive layer which is not easily dissolved by the saliva when attached to a tooth and is not crosslinked.

For example, the pressure-sensitive adhesive layer of the present invention may contain, as a total weight of the pressure-sensitive adhesive layer, cellulose acetate, 1 to 50% by weight of an acrylate copolymer selected from the group consisting of acrylate copolymer, methacrylate acrylate copolymer, acrylate copolymer, methacrylate acrylate copolymer, sodium acrylate, and acrylic acid copolymer as monomers, glycerin, From 1 to 5% by weight of at least one selected from the group consisting of butylene glycol and ethylene glycol, 0.01 to 1% by weight of at least one of aluminum glycinate and aluminum hydroxide, and 0.1 to 30% . The physical property adjusting agent may be sodium adipate, tartaric acid, and the like.

The adhesive layer may have a thickness of 10 to 500 mu m. If the thickness is less than 10 mu m, it is difficult to exhibit a sufficient adhesive force to the teeth or to adhere for a sufficient time to obtain a whitening effect. When the thickness is more than 500 mu m,

In the present invention, the adhesive layer may further comprise a support. The support may be at least one film selected from the group consisting of polyethylene, polyester, polypropylene, urethane and ethylene vinyl acetate. It is also preferable that the support has a thickness of 5 to 50 탆.

In the present invention, the tooth whitening component is separately provided from the tooth whitening patch, and the teeth whitening component is injected (loaded) into the reservoir of the patch at the time of use. The tooth whitening ingredient in the present invention is not particularly limited as long as it has a tooth whitening effective ingredient.

Preferably, the tooth whitening component may comprise hydrogen peroxide.

In addition, the tooth whitening component may further comprise at least one member selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, and sodium carboxymethyl cellulose.

In addition, the tooth whitening component may further comprise a stabilizer. The stabilizing agent is not particularly limited as long as it is a substance that stabilizes an efficacious ingredient for tooth whitening, for example, hydrogen peroxide to enhance stability. Preferably, the stabilizer may be at least one selected from the group consisting of sodium stannate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite.

The stabilizing agent is preferably 0.01 to 2% by weight based on the total weight of the tooth whitening component. If it is less than 0.01% by weight, the effect of stabilizing hydrogen peroxide is low, and if it is more than 2% by weight, the stabilizer component acts as an impurity, and the stability of hydrogen peroxide is lowered.

The tooth whitening ingredient is acidic, preferably pH 6 or less, more preferably pH 5 or less. And may be specifically from pH 2 to pH 5. When pH is less than 2, the acidity is high and the oral stimulation is severe. When the pH is more than 6, the stability of hydrogen peroxide may be lowered.

In the present invention, the tooth whitening component is a liquid agent or gel agent having fluidity. In the present invention, the liquid agent means a liquid formulation, and the gel agent means a gel agent formulation. In the present invention, the tooth whitening component of the liquid or gel may have a viscosity of 100 to 10,000 cps, preferably 200 to 9,000 cps, and more preferably 500 to 5,000 cps. If the viscosity is less than 100 cps, it may be impregnated into the storage tank and flowed to the gums when adhered. If the viscosity exceeds 10,000 cps, it is difficult to impregnate the contents into the storage tank. In the present invention, since the component for tooth whitening of a liquid or a gel has fluidity, the diffusion speed to the tooth surface is fast, and an excellent effect can be achieved.

The tooth whitening component may further comprise an aging agent, and the aging agent is not particularly limited, but may be, for example, polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP), or the like.

For example, the tooth whitening component of the present invention may contain at least one to 20% by weight of at least one member selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone and sodium carboxymethyl cellulose, By weight of a sweetening agent (for example, saccharin (sodium saccharin), sodium alginate, sodium alginate, sodium alginate, sodium alginate, ) 0.01 to 5% by weight.

The present invention also provides a tooth whitening method using the tooth whitening patch. That is, the tooth whitening method of the present invention may be a method of injecting (loading) a component for whitening teeth of a liquid or gel separately provided in a storage tank, and then attaching an adhesive layer to teeth.

The tooth whitening ingredient of the liquid or gel separately provided in the present invention may be a tube or a blister pack.

The method of injecting (loading) the tooth whitening ingredient of the liquid agent or the gel is a method in which a storage tank is immersed in the contents (tooth whitening ingredient of a liquid or a gel) to be sacked, or the contents are squeezed out from a tube To impregnate the whitening ingredient into the reservoir of the patch.

The tooth whitening patch of the present invention can be used as a tooth whitening patch for tooth whitening by impregnating the tooth whitening effect ingredient of the liquid or gel into the reservoir of the patch while taking advantage of the advantage that the tooth whitening component of the liquid or gel- It is possible to minimize the loss of tooth whitening effect component due to the saliva, and the stability of the tooth whitening efficacious ingredient is maintained until use, and the activity of the tooth whitening effective ingredient is enhanced during use to obtain an excellent tooth whitening effect Not only is it possible to relieve irritation to teeth and gums, it is excellent in feeling.

The present invention will be described in more detail through the following examples. However, the examples are for illustrating the present invention, and the scope of the present invention is not limited thereto.

[Examples 1 to 4] Preparation of ingredients for tooth whitening of liquid and gel formulations

Each ingredient was diluted as shown in Table 1 below to prepare a tooth whitening ingredient for a liquid and a gel using an Ajmi mixer.

ingredient Example 1 Example 2 Example 3 Example 4 PVA 217 13.50 - 3.00 5.00 PVA 205 - 10.00 - 7.00 PVP K30 - - - 2.00 Citric acid monohydrate
(Citric acid monohydrate) 0.15 0.20 0.15 0.20 35% hydrogen peroxide 8.75 8.75 8.75 8.75 saccharin 0.02 0.03 0.02 0.03 ethanol 30.00 30.00 25.00 25.00 Sodium stannate 0.1 0.1 0.1 0.1 Flavor 1.00 1.00 1.00 1.00 water To 100 To 100 To 100 To 100

[Experimental Example 2] Viscosity and pH measurement of liquid and gel formulations

In order to measure the viscosity of the liquid formulations and the gel formulations according to Examples 1 to 4, the contents were placed in a 50 ml viscous bottle to remove bubbles, and then the viscosity of the contents was measured using a Brookfield viscometer. In order to measure the pH of each contents, 5 g was taken in a 100 ml beaker, diluted 10 times with distilled water, and pH of the solution and the gel formulation were measured with a pH meter. The results are shown in Table 2 below.

ingredient Example 1 Example 2 Example 3 Example 4 Viscosity (cps) 8,710 6,240 270 6,850 pH 3.91 3.70 3.90 3.68

[Examples 5 to 10] Manufacture of a tooth adhesive layer (adhesive tape)

After the adhesive solution was prepared so as to have a total content of 50 g as shown in Table 3 below, the silicone-treated polyester film or polyethylene-laminated paper film was laminated so that the adhesive layer had a thickness of 100 to 200 占 퐉 , Dried at 50 캜 for 20 minutes in a hot air drier, and laminated with HDPE (high density polyethylene) film having a thickness of 20 탆 to prepare a tooth adhesive tape. Adhesive tapes prepared by crosslinking using acrylic acid and aluminum glycinate, which is a crosslinking agent, were pouch packed and aged at 50 캜 for 3 days to prepare a final tooth adhesive tape.

ingredient Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Acrylic acid 10% 10 10 - - - CMC Na
(Sodium carboxymethyl cellulose) 10% 8 - - 5 5 PVP K90 - 15 10 15 Eudragit PO 100 - 2 10 5 5 2 glycerin 15 - 12 PEG400 - 15 - 15 1,3-butylene glycol - - 12 - - 15 Aluminum glycinate 0.05 0.05 0.05 - - - water 10 10 10 5 5 ethanol To 100 To100 To 100 To 100 To 100 To 100

[Examples 11 to 16] Preparation of a reservoir (reservoir) coated with hydrogen peroxide activator

Hydrogen peroxide activator (also referred to as boosting agent) for accelerating the decomposition of hydrogen peroxide and lowering the acidity of the liquid formulation and the gel formulation was prepared as an aqueous solution having a proper concentration as shown in Table 4 below. Then, a nonwoven fabric or a modified nonwoven fabric to be used as a storage tank was immersed in the aqueous solution and then taken out, followed by drying to completely remove moisture, thereby preparing a storage tank coated with hydrogen peroxide activator.

Configuration Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Cotton nonwoven fabric (100 g) 0 Cotton nonwoven fabric (60 g) 0 Rayon nonwoven fabric (60g) 0 Rayon nonwoven fabric (40g) 0 The modified cellulose nonwoven fabric (100 g) 0 The modified cellulosic nonwoven fabric (60 g) 0 NaOH 0.5 N solution coating 0 0 NaOH 0.1N solution coating 0 0 Sodium bicarbonate solution 1N solution 0 0

[Examples 17 to 21] Preparation of reservoir type patches

A reservoir type patch was produced with the structure shown in Table 5 below. More specifically, after preparing the tape by cutting the tape to a size of 6 cm * 1 cm, the tape was cut to a size of 8 cm * 2 cm, and then the release film was peeled off from the tape. And then a release type patch was produced by covering the release film again.

Component Example 17 Example 18 Example 19 Example 20 Example 21 Tooth Adhesive Tape The adhesive tape according to Example 5 The adhesive tape according to Example 7 The adhesive tape according to Example 9 The adhesive tape according to Example 5 The adhesive tape according to Example 9 Storage tank
(Reservoir) The storage tank according to Example 11 The storage tank according to Example 13 The storage tank according to Example 14 The storage tank according to Example 15 The storage tank according to Example 16

[Comparative Example 1] Preparation of a reservoir type patch not coated with hydrogen peroxide activator

After cutting a cotton nonwoven fabric (100 g) having no hydrogen peroxide activator coated thereto to a size of 6 cm * 1 cm, the tooth adhesive tape prepared by the method of Example 5 was cut into a size of 8 cm * 2 cm, and the release film of the tape was peeled off And then the storage tank was placed so that the rim was 0.5 cm each, and then the release film was covered again.

[Experimental Examples 1 to 4] Evaluation of in vitro tooth whitening efficacy

1) Preparation of Contaminated Hydroxyapatite (HAP) Tablet Specimen

The tablet of hydroxyapatite powder was sintered at 1000 ℃ and molded with epoxy resin. The surface was etched with strong acid, and TSB (trypticase soybroth) solution in which tea, coffee, iron, The process of soaking and drying the specimens was continued for one week and contaminated. After contamination, the specimen was lightly rinsed with running water by using a toothbrush to remove water-soluble or easily dissolved contaminants and then dried at room temperature.

2)

The initial L value of the HAP tablet specimens contaminated with various factors (L represents lightness, whiteness at 100 and black at 0) were measured with a colorimeter, and the teeth whitening patches prepared in the above- The patch was detached after a certain period of time, washed lightly with a toothbrush, and then dried at room temperature. Then, L Respectively. Thus, the difference ΔL before and after patch attachment was obtained. The contents of the experiment and the results are shown in Table 6 below.

Contents After one hour ΔL After 3 hours ΔL Experimental Example 1 The release film was removed from the patch prepared by the method of Example 15, 0.5 g of the whitening gel prepared by the method of Example 1 was loaded on a reservoir, and after the reservoir reached the specimen, a change in L value was measured Respectively. 35.5 ± 4.3 43.8 ± 5.1 Experimental Example 2 The release film was removed from the patch prepared by the method of Example 11, and 0.5 g of the whitening gel prepared by the method of Example 1 was loaded on the reservoir, and after the reservoir reached the specimen, the change of the L value was measured. 37.4 ± 3.9 44.2 ± 4.5 Experimental Example 3 The release film was removed from the patch prepared by the method of Example 12, 0.5 g of the whitening gel prepared by the method of Example 2 was loaded on the reservoir, and after the reservoir reached the specimen, the change of L value was measured. 33.6 ± 5.8 39.6 ± 4.6 Experimental Example 4 The release film was removed from the patch prepared by the method of Example 15, 0.5 g of the whitening gel prepared by the method of Example 3 was loaded on the reservoir, and after the reservoir reached the specimen, the change of the L value was measured. 40.8 ± 4.5 44.9 ± 5.1 Comparative Example 2 The release film was removed from the patch prepared by the method of Comparative Example 1, 0.5 g of the whitening gel prepared by the method of Example 1 was loaded on the reservoir, and after the reservoir reached the specimen, the change of the L value was measured. 21.3 ± 4.3 26.6 ± 6.2

[Experimental Example 5] Improvement of irritation

A whitening formulation containing a tooth whitening active ingredient was injected (loaded) into the reservoir of the patch and adhered to the teeth, and the stimulation sensation at the adhered area was evaluated. The patches were attached to the teeth, and the sensation of irritation was evaluated as 0 when there was no stimulation at all and 10 when the irritation was too strong and the attachment was impossible. The results are shown in Table 7 below.

Subject Immediately after attachment After 5 minutes, the irritability index Experimental Example 1 Comparative Example 2 Experimental Example 1 Comparative Example 2 Subject 1 2 6 One 2 Subject 2 3 5 0 One Subject 3 3 6 2 2 Subject 4 4 7 One 3 Subject 5 One 6 2 One Subject 6 2 6 2 2 Subject 7 5 8 One One Subject 8 4 8 One 3 Subject 9 3 7 0 2 Subject 10 2 7 One One Average 2.9 ± 1.2 6.6 ± 1.0 1.1 ± 0.7 1.8 ± 0.8

Claims (20)

An adhesive layer attached to the teeth; And
And a reservoir capable of contacting with a part of the surface of the adhesive layer adhered to the teeth and capable of impregnating the liquid agent or the gel agent,
A tooth-whitening patch for reservoir-type tooth whitening which injects a tooth whitening ingredient of a separate liquid or gel into the reservoir. The method according to claim 1,
Wherein the surface of the adhesive layer adhered to the teeth is protected by a release paper. The method according to claim 1,
Wherein the tooth whitening component comprises hydrogen peroxide. The method of claim 3,
Wherein the tooth whitening component further comprises at least one member selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone, and sodium carboxymethyl cellulose. The method of claim 3,
Wherein the tooth whitening component further comprises a stabilizer. 6. The method of claim 5,
Wherein the stabilizing agent is selected from the group consisting of sodium stannate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite. The method according to claim 1,
Wherein the tooth whitening component is a liquid or gel formulation having a viscosity of 100 to 10,000 cps. The method according to claim 1,
Wherein said reservoir is at least one selected from the group consisting of natural or synthetic nonwovens, natural or synthetic wovens, natural or synthetic nonwoven fabric, hydrophilic modified fibers and urethane based foams. The method according to claim 1,
Wherein the reservoir is impregnated with a liquid or gel of 1 to 30 times the weight of the reservoir itself. The method according to claim 1,
Wherein the reservoir is 0.01 to 5 mm thick. The method according to claim 1,
Wherein the reservoir further comprises a hydrogen peroxide activator. 12. The method of claim 11,
Wherein the hydrogen peroxide activator is at least one selected from the group consisting of sodium hydroxide, sodium bicarbonate, and sodium percarbonate. The method according to claim 1,
Wherein the adhesive layer comprises at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer. The method according to claim 1,
The pressure-sensitive adhesive layer may be formed of at least one selected from the group consisting of cellulose gum, hydroxypropyl methylcellulose, hydroxyethylcellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, aminomethacrylic copolymer, methacrylic acid Ethyl acrylate copolymer, sodium polyacrylate, and an acrylate copolymer containing acrylic acid as a monomer. 15. The method of claim 14,
Wherein the adhesive layer further comprises at least one selected from the group consisting of glycerin, butylene glycol, and ethylene glycol. The method according to claim 1,
Wherein the adhesive layer has a thickness of 10 to 500 mu m. The method according to claim 1,
Wherein the adhesive layer further comprises a support. 18. The method of claim 17,
Wherein the support is at least one film selected from the group consisting of polyethylene, polyester, polypropylene, urethane and ethylene vinyl acetate. A tooth whitening method using a tooth whitening patch according to any one of claims 1 to 18. 20. The method of claim 19,
Wherein the tooth whitening method comprises injecting the tooth whitening ingredient of the separate liquid or gel into the reservoir, and attaching the adhesive layer to the tooth.