KR102348043B1 - Reservoir-type patch for tooth whitening - Google Patents

Abstract

The present invention is an adhesive layer attached to the tooth; and a reservoir that is in contact with a part of the surface of the adhesive layer attached to the teeth and can be impregnated with a liquid or gel, and a separate liquid or gel for tooth whitening component is injected into the reservoir for teeth whitening provide patches. According to the reservoir type tooth whitening patch of the present invention, the long-term stability of the effective tooth whitening ingredient is improved before use, so that the decrease in the content of the effective ingredient is minimized during the period of use of the product, and the activity of the tooth whitening ingredient is improved during use By accelerating decomposition, you can get a quick and effective tooth whitening effect.

Description

Reservoir type tooth whitening patch {RESERVOIR-TYPE PATCH FOR TOOTH WHITENING}

The present invention relates to a reservoir type tooth whitening patch, and more particularly, to a reservoir type tooth whitening patch used by injecting a liquid or gel tooth whitening component into a reservoir capable of impregnating the liquid or gel.

Recently, interest in dental care for cosmetic purposes is increasing, and especially, white and bright teeth are considered as important elements of beauty. In addition to the professional teeth whitening procedures received at dentists, interest in self-care teeth whitening agents that can be easily purchased in the market is also increasing, and various products are already on the market. Representative products include toothpaste containing hydrogen peroxide or its precursor carbamide peroxide, wet patches, dry patches, and products in combination with trays.

In general, the esthetics of teeth are affected by the arrangement, size, color, texture, and light permeability of teeth. In particular, the color of teeth is a very important factor. The importance of teeth whitening is increasing as it can cause problems in the teeth.

Teeth turn yellow as compounds such as tannins or polyphenols contained in various foods we consume penetrate and color the tooth surface, enamel or dentin. It can be removed simply by brushing the teeth or other physical methods colored on the tooth surface, but the colored substances that have penetrated into the enamel or dentin are not easily removed. have. In other words, tooth whitening refers to a method of improving discolored or colored enamel and dentin into white and transparent colors by using the action of a whitening component.

As effective ingredients mainly used for teeth whitening, hydrogen peroxide or carbamide peroxide are used. These effective ingredients are decomposed under various conditions to generate free radicals, which are attached to the teeth to react with organic matter and It is known that teeth whitening is achieved by changing the color chromophore to non-colored chromophores. In this way, hydrogen peroxide, which exhibits a tooth whitening effect, must be decomposed into free radicals to exhibit a tooth whitening effect. is known

However, in the case of home-use tooth whitening agents, in order to be commercially viable as a product, the hydrogen peroxide content must be maintained at a certain level or more for a period of use of about 2 years or more. In other words, it was necessary to develop a product with an excellent effect of promoting the formation of free radicals through a rapid decomposition process when the hydrogen peroxide-type tooth whitening agent is stable in the tooth whitening formulation.

As interest in teeth whitening for cosmetic purposes has increased, a variety of personal teeth whitening products that can be used directly by consumers are on the market. However, in the case of toothpaste, even if it contains ingredients with excellent whitening effect, the whitening effect is not great due to the short contact time. Although it is in contact with the teeth for a long time, it is easily washed off by saliva, etc., so the teeth whitening effect is not satisfactory. And in the case of the patch formulation, compared to the toothpaste or gel formulation, the contact time with the teeth is increased, but it is difficult to contain a large amount of whitening ingredients in the manufacturing process, and improvements are needed to obtain a quick effect upon contact with the teeth.

The currently developed tooth whitening patch has the highest sales in the market because the dry single-layer patch has a good feeling and relatively good efficacy. However, it is not easy to increase the content of the main component due to difficulties in the manufacturing process, and the diffusion rate of the main component to the tooth surface is slower than that of a liquid or gel formulation, so improvement is needed in terms of efficacy.

Republic of Korea Patent Publication No. 2002-0001620

In order to solve the above problems, an object of the present invention is to provide a reservoir-type tooth whitening patch that can be used by attaching to the teeth after injecting a separate liquid or gel tooth whitening component into the storage tank.

In order to solve the above object, the present invention provides an adhesive layer attached to teeth; and a reservoir that is in contact with a part of the surface of the adhesive layer attached to the teeth and can be impregnated with a liquid or gel, and a separate liquid or gel for tooth whitening component is injected into the reservoir for teeth whitening provide patches.

In one embodiment of the present invention, the surface of the adhesive layer attached to the teeth may be protected with a release paper.

In one embodiment of the present invention, the tooth whitening component may include hydrogen peroxide.

In one embodiment of the present invention, the tooth whitening component may further include one or more selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, and sodium carboxymethyl cellulose.

In one embodiment of the present invention, the tooth whitening component may further include a stabilizer.

In one embodiment of the present invention, the stabilizer may be at least one selected from the group consisting of sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite.

In one embodiment of the present invention, the tooth whitening component may be a liquid or gel formulation having a viscosity of 100 to 10,000 cps.

In one embodiment of the present invention, the storage tank may be at least one selected from the group consisting of natural or synthetic nonwoven fabrics, natural or synthetic woven fabrics, hydrophilic modified fibers of natural or synthetic nonwoven fabrics, and urethane-based foams.

In one embodiment of the present invention, the storage tank may be one capable of impregnating 1 to 30 times the amount of liquid or gel based on the weight of the storage tank itself.

In one embodiment of the present invention, the storage tank may have a thickness of 0.01 to 5 mm.

In one embodiment of the present invention, the storage tank may further include a hydrogen peroxide activator.

In one embodiment of the present invention, the hydrogen peroxide activator may be at least one selected from the group consisting of sodium hydroxide, sodium bicarbonate and sodium percarbonate.

In one embodiment of the present invention, the adhesive layer may be made of at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer.

In one embodiment of the present invention, the adhesive layer is cellulose gum, hydroxypropyl methylcellulose, hydroxyethyl cellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, It may include at least one selected from the group consisting of aminomethacrylic copolymer, methacrylic acid ethyl acrylate copolymer, sodium polyacrylate and acrylate copolymer containing acrylic acid as monomers.

In one embodiment of the present invention, the adhesive layer may further include one or more selected from the group consisting of glycerin, butylene glycol and ethylene glycol.

In one embodiment of the present invention, the adhesive layer may have a thickness of 10 to 500㎛.

In one embodiment of the present invention, the adhesive layer may further include a support.

In one embodiment of the present invention, the support may be one or more films selected from the group consisting of polyethylene, polyester, polypropylene, urethane and ethylene vinyl acetate.

In addition, the present invention provides a tooth whitening method using the tooth whitening patch.

In one embodiment of the present invention, the tooth whitening method may be to attach the adhesive layer to the teeth after injecting the tooth whitening component of the separate liquid or gel into the storage tank.

According to the reservoir type tooth whitening patch of the present invention, the long-term stability of the effective tooth whitening ingredient is improved before use, so that the decrease in the content of the effective ingredient is minimized during the period of use of the product, and the activity of the tooth whitening ingredient is improved during use By accelerating decomposition, you can get a quick and effective tooth whitening effect. In addition, while using the advantage that the tooth whitening component of liquid or gel has a fast diffusion rate to the tooth surface as it is, the tooth whitening effective component of liquid or gel is impregnated into the reservoir of the patch to attach the patch to the teeth. It can minimize the loss of tooth whitening ingredients, and it relieves irritation to the teeth and gums, so the feeling of use is excellent.

Hereinafter, in order to enable those of ordinary skill in the art to easily practice the present invention, preferred embodiments of the present invention will be described in detail.

The present invention is an adhesive layer attached to the tooth; and a reservoir that is in contact with a part of the surface of the adhesive layer attached to the teeth and can be impregnated with a liquid or gel, and a separate liquid or gel for tooth whitening component is injected into the reservoir for teeth whitening provide patches.

In the reservoir type tooth whitening patch according to the present invention, a storage tank (storage layer) capable of impregnating a liquid or gel is in contact with an adhesive layer capable of attaching teeth, and when in use, a separate liquid or gel tooth whitening agent is placed in the storage tank. It is to inject (load) the solvent component. In the present invention, the storage tank is also referred to as a reservoir (reservoir).

The reservoir may be provided between the teeth and the adhesive layer, and the adhesive layer preferably has a slightly larger area than the reservoir so that it can be attached to the teeth. That is, on the surface of the adhesive layer attached to the teeth, a storage tank having a size smaller than that of the adhesive tank is attached.

In the present invention, the surface of the adhesive layer attached to the teeth may be protected with a release paper or a release film, and it is preferable to remove the release paper or the release film before use. That is, on the surface of the adhesive layer attached to the teeth, a storage tank smaller than the adhesive tank is attached, and the entire surface of the adhesive layer including the storage tank attached to the teeth is covered with a release paper or a release film to protect it.

The release paper or release film protects the patch from contamination and damage until use. The release paper or release film is not particularly limited, but may be a polyethylene terephthalate or polypropylene film, and may be one coated with silicone or Teflon on one side for easy removal when using the patch.

In the present invention, the storage tank is not particularly limited as long as it is made of a material that can be impregnated with a liquid or gel. Preferably, the storage tank may be at least one selected from the group consisting of natural or synthetic nonwoven fabrics, natural or synthetic woven fabrics, hydrophilic modified fibers of natural or synthetic nonwoven fabrics, and urethane-based foams.

The storage tank may be one capable of impregnating 1 to 30 times the weight of the storage tank itself, specifically 1 to 10 times the liquid or gel.

The reservoir may be a layer having a thickness of 0.01 to 5 mm. If the thickness is less than 0.01mm, the amount of impregnation of the hydrogen peroxide content is too small, so the tooth whitening effect is low.

In the present invention, the storage tank may further include a hydrogen peroxide activator.

As described above, the tooth whitening component may further include a stabilizer, and this stabilizer serves to improve the stability of hydrogen peroxide during the distribution period of the patch. Considering the mechanism of whitening, it can act as a negative factor by lowering the activity of hydrogen peroxide. Therefore, it is preferable to further include a hydrogen peroxide activator capable of accelerating the whitening action of the stabilized hydrogen peroxide in order to obtain an optimal whitening effect when used. In addition, the liquid or gel formulation has good flowability and is relatively likely to cause irritation to the teeth or gums. It can relieve irritation by neutralizing it, and in the process, it can promote the decomposition of hydrogen peroxide, which can increase the production of free radicals.

The hydrogen peroxide activator may be at least one selected from the group consisting of sodium hydroxide, sodium bicarbonate and sodium percarbonate.

The hydrogen peroxide activator is preferably 0.01 to 5% by weight based on the total weight of the storage tank. If it is less than 0.01% by weight, the effect of the activator is insignificant, and if it is more than 5% by weight, it may be activated too quickly or give irritation to the teeth or gums.

In the present invention, one side of the adhesive layer is in contact with the reservoir and the other side is a layer that is attached to the teeth, and the adhesive layer has adhesive strength when in contact with the moisture of the teeth, so if it is made of a material that can be attached to the teeth, it is particularly limited it is not going to be

The pressure-sensitive adhesive layer may be prepared by, for example, dissolving the pressure-sensitive adhesive layer composition in a solvent such as water or ethanol, and then coating the composition using a moisture-impermeable film as a support and then drying.

Preferably, the adhesive layer may be made of at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer. Specifically, the adhesive layer is cellulose gum, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, aminomethacrylic acid It may include at least one selected from the group consisting of a polymer, methacrylic acid ethyl acrylate copolymer, sodium polyacrylate, and acrylate copolymer containing acrylic acid as a monomer.

Specifically, the hydrophilic polymer may further include a plasticizer based on the hydrophilic polymer. The plasticizer may be at least one selected from the group consisting of glycerin, butylene glycol, propylene glycol, dipropylene glycol, pentylene glycol, sorbitol and ethylene glycol. For example, the hydrophilic polymer is cellulose gum, hydroxypropyl methylcellulose, hydroxyethyl cellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, aminomethacrylic It may be a copolymer, a methacrylic acid ethyl acrylate copolymer, an acrylate copolymer containing sodium polyacrylate and acrylic acid as monomers, and the like.

In addition, the cross-linkable water-soluble polymer may further include a plasticizer and/or a cross-linking agent with a specifically cross-linkable water-soluble polymer as a main chain. The plasticizer is the same as described above, and the crosslinking agent may be at least one of aluminum glycinate and aluminum hydroxide. For example, the crosslinkable water-soluble polymer may be at least one of polyacrylic acid, sodium polyacrylate, and an acrylate copolymer using acrylic acid as a monomer. In particular, the cross-linked adhesive layer has the advantage of being able to adhere for a long time compared to the non-cross-linked tooth adhesive layer because it is not easily dissolved by saliva when attached to the tooth.

For example, the adhesive layer of the present invention may include cellulose gum, hydroxypropyl methyl cellulose, hydroxyethyl cellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid, based on the total weight of the adhesive layer. 1 to 50% by weight of at least one selected from the group consisting of a late cross polymer, an aminomethacrylic copolymer, a methacrylic acid ethyl acrylate copolymer, sodium polyacrylate, and an acrylate copolymer containing acrylic acid as a monomer, glycerin, 5 to 50% by weight of at least one selected from the group consisting of butylene glycol and ethylene glycol, 0.01 to 1% by weight of at least one of glycinate (Aluminium Glycinate) and aluminum hydroxide, and 0.1 to 30% by weight of a physical property modifier may be doing The physical property modifier may be sodium EDTA and tataric acid.

The adhesive layer may have a thickness of 10 to 500 μm. If the thickness is less than 10㎛, it is difficult to express sufficient adhesion to the teeth or it is difficult to attach for a sufficient time to obtain a whitening effect, and if it is more than 500㎛, it is inconvenient to have a large foreign body feeling when attached to the teeth.

In the present invention, the adhesive layer may further include a support. The support may be one or more films selected from the group consisting of polyethylene, polyester, polypropylene, urethane, and ethylene vinyl acetate. In addition, the support preferably has a thickness of 5 to 50㎛.

In the present invention, the tooth whitening component is provided separately from the tooth whitening patch, and when used, the tooth whitening component is injected (loaded) into the storage tank of the patch and used. In the present invention, the tooth whitening component is not particularly limited as long as it has a tooth whitening effective component.

Preferably, the tooth whitening component may include hydrogen peroxide.

In addition, the tooth whitening component may further include one or more selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, and sodium carboxymethyl cellulose.

In addition, the tooth whitening component may further include a stabilizer. The stabilizer is not particularly limited as long as it is a material that increases stability by stabilizing an effective ingredient for teeth whitening, for example, hydrogen peroxide. Preferably, the stabilizer may be at least one selected from the group consisting of sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride and laponite.

The stabilizer is preferably 0.01 to 2% by weight based on the total weight of the tooth whitening component. If it is less than 0.01% by weight, the hydrogen peroxide stabilizing effect is low, and if it is more than 2% by weight, the stabilizer component acts as an impurity, and the stability of hydrogen peroxide is rather reduced.

The tooth whitening component is acidic, and preferably has a pH of 6 or less, and more preferably a pH of 5 or less. Specifically, it may be pH2 to pH5. If the pH is less than 2, the acidity is high and irritation in the oral cavity is severe, and if the pH is more than 6, the stability of hydrogen peroxide may be lowered.

In the present invention, the tooth whitening component is a liquid or gel having fluidity, and in the present invention, the liquid means a liquid formulation, and the gel means a gel formulation. In the present invention, the tooth whitening component of the liquid or gel may have a viscosity of 100 to 10,000 cps, preferably 200 to 9,000 cps, more preferably 500 to 5,000 cps. If the viscosity is less than 100cps, the effect may be low when it is impregnated and attached to the reservoir, and the effect may be low, and if it exceeds 10,000cps, it is difficult to impregnate the contents in the reservoir. In the present invention, since the tooth whitening component of the liquid or gel has fluidity, an excellent effect can be achieved because the diffusion rate to the tooth surface is fast.

The tooth whitening component may further include a thickener, and the thickener is not particularly limited, but may be, for example, polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), or the like.

For example, the tooth whitening component of the present invention may contain 1 to 20% by weight of at least one selected from the group consisting of polyvinyl alcohol, polyvinylpyrrolidone, and sodium carboxymethyl cellulose based on the total weight of the tooth whitening component, hydrogen peroxide 1 to 20% by weight, stabilizer (eg sodium stearate) 0.01-2% by weight, citric acid 0.01-2% by weight, ethanol 1-50% by weight, water 1-50% by weight, sweetener (eg saccharin) ) may be included in an amount of 0.01 to 5% by weight.

In addition, the present invention provides a tooth whitening method using the tooth whitening patch. That is, the tooth whitening method of the present invention may be to first inject (load) a tooth whitening component of a liquid or gel separately provided in a storage tank, and then attach an adhesive layer to the teeth.

In the present invention, the component for teeth whitening of a liquid or gel separately provided may be provided in a tube or blister packaging form.

In addition, the method of injecting (loading) the tooth whitening component of the liquid or gel is impregnated by immersing the storage tank in the small packaged contents (a liquid or gel component for teeth whitening), or squeezing the contents out of a tube. As such, it may be impregnated with a whitening ingredient in the storage tank of the patch.

The reservoir type tooth whitening patch according to the present invention utilizes the advantage that the tooth whitening component of liquid or gel has a fast diffusion rate to the tooth surface, while impregnating the tooth whitening effect of liquid or gel into the reservoir of the patch to prepare the patch. Since it is attached to the teeth, loss of the effective tooth whitening ingredient due to saliva can be minimized, and the stability of the tooth whitening ingredient is maintained until use. Not only can it be used, but it also relieves irritation to teeth and gums, so the feeling of use is excellent.

The present invention will be described in more detail through the following practice. However, the examples are for illustrative purposes only, and the scope of the present invention is not limited thereto.

[Examples 1-4] Preparation of ingredients for teeth whitening in liquid and gel formulations

As shown in Table 1 below, each component was weighed to prepare a tooth whitening component in liquid and gel using an aji mixer.

ingredient Example 1 Example 2 Example 3 Example 4 PVA 217 13.50 - 3.00 5.00 PVA 205 - 10.00 - 7.00 PVP K30 - - - 2.00 citric acid monohydrate
(Citric acid monohydrate) 0.15 0.20 0.15 0.20 35% hydrogen peroxide 8.75 8.75 8.75 8.75 saccharin 0.02 0.03 0.02 0.03 ethanol 30.00 30.00 25.00 25.00 sodium stannate 0.1 0.1 0.1 0.1 Flavor 1.00 1.00 1.00 1.00 water To 100 To 100 To 100 To 100

[Experimental Example 2] Measurement of viscosity and pH of liquid and gel formulations

To measure the viscosity of the liquid and gel formulations according to Examples 1 to 4, the contents were placed in a 50 ml viscosity bottle to remove air bubbles, and then the viscosity of the prepared contents was measured using a Brookfield viscometer. In addition, in order to measure the pH of each content, 5 g was taken in a 100 ml beaker, diluted 10-fold with distilled water, and then the pH of the liquid and gel formulations was measured with a pH meter. The results are shown in Table 2 below.

ingredient Example 1 Example 2 Example 3 Example 4 Viscosity (cps) 8,710 6,240 270 6,850 pH 3.91 3.70 3.90 3.68

[Examples 5-10] Preparation of a tooth adhesive layer (adhesive tape)

After preparing an adhesive solution so that the total content is 50 g with the composition shown in Table 3 below, and after standing for a certain period of time and drying, the silicone-treated polyester film or polyethylene-laminated paper release paper so that the thickness of the adhesive layer becomes 100 to 200 μm After casting on the top and drying in a hot air dryer for 20 minutes at 50 ℃ was laminated with a 20㎛ thick HDPE (High Density Polyethylene) film to prepare a tooth adhesive tape. The adhesive tape prepared by crosslinking using acrylic acid and aluminum glycinate as a crosslinking agent was packaged in a pouch and aged at 50° C. for 3 days to prepare a final dental adhesive tape.

ingredient Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 acrylic acid 10% 10 10 - - - CMC Na
(Sodium Carboxymethylcellulose) 10% 8 - - 5 5 PVP K90 - 15 10 15 Eudragit PO 100 - 2 10 5 5 2 glycerin 15 - 12 PEG400 - 15 - 15 1,3-butylene glycol - - 12 - - 15 aluminum glycinate 0.05 0.05 0.05 - - - water 10 10 10 5 5 ethanol To 100 To100 To 100 To 100 To 100 To 100

[Examples 11 to 16] Preparation of a storage tank (reservoir) coated with a hydrogen peroxide activator

A hydrogen peroxide activator (also referred to as a boosting material) for accelerating the decomposition of hydrogen peroxide and for lowering the acidity of liquid and gel formulations was prepared as an aqueous solution having an appropriate concentration as shown in Table 4 below. Then, a non-woven fabric or a modified non-woven fabric to be used as a storage tank was immersed in this aqueous solution and then dried to completely remove moisture to prepare a storage tank coated with a hydrogen peroxide activator.

composition Example 11 Example 12 Example 13 Example 14 Example 15 Example 16 Cotton non-woven fabric (100g) 0 Cotton Nonwoven (60g) 0 Rayon non-woven fabric (60 g) 0 Rayon nonwoven fabric (40g) 0 Modified Cellulose Nonwoven (100g) 0 Modified Cellulose Nonwoven (60g) 0 NaOH 0.5 N solution coating 0 0 NaOH 0.1N solution coating 0 0 Sodium bicarbonate 1N solution coating 0 0

[Examples 17-21] Reservoir-type patch production

A reservoir-type patch was prepared with the configuration shown in Table 5 below. More specifically, the size of the storage tank is cut to be 6cm * 1cm, prepared by cutting the tooth adhesive tape to the size of 8cm * 2cm, and then peeled off the release film from the tape, and the storage tank is positioned so that the edges are each 0.5cm A reservoir-type patch was prepared by covering the release film again.

Component Example 17 Example 18 Example 19 Example 20 Example 21 tooth adhesive tape Adhesive tape according to Example 5 Adhesive tape according to Example 7 Adhesive tape according to Example 9 Adhesive tape according to Example 5 Adhesive tape according to Example 9 reservoir
(reservoir) Reservoir according to Example 11 Reservoir according to Example 13 Reservoir according to Example 14 Reservoir according to Example 15 Reservoir according to Example 16

[Comparative Example 1] Preparation of reservoir-type patch not coated with hydrogen peroxide activator

After cutting a cotton nonwoven fabric (100 g) not coated with a hydrogen peroxide activator to a size of 6 cm * 1 cm, the tooth adhesive tape prepared by the method of Example 5 was prepared by cutting it to a size of 8 cm * 2 cm, peeling off the release film of the tape, It was prepared by placing the storage tank so that the edges were 0.5 cm, respectively, and then covering the release film again.

[Experimental Examples 1-4] In vitro tooth whitening efficacy evaluation

1) Preparation of contaminated hydroxyapatite (HAP) tablet specimens

After making a tablet with an IR press, hydroxyapatite powder was sintered at 1000°C, molded with an epoxy resin to make a specimen, etched the surface with a strong acid, and then a TSB (trypticase soybroth) solution in which tea, coffee, iron, and mucin were dissolved. The process of dipping and drying the specimen in the air was continued for 1 week to contaminate. After contamination, the specimen was lightly washed under running water with a toothbrush to remove contaminants that were soluble or easily soluble in water, and then dried at room temperature.

2) Whitening effect evaluation method

The initial L value of the HAP tablet specimen contaminated with various factors (L represents lightness, white when 100, black when 0) was measured with a colorimeter, and the tooth whitening patches prepared in Examples and Comparative Examples were soaked in water. Attach it to the wet specimen, store it in a thermo-hygrostat adjusted to 37°C and 95% humidity to make it similar to actual oral conditions. The values were measured. Thus, ΔL, which is the difference before and after patch attachment, was obtained. Experimental details and results are shown in Table 6 below.

Contents ΔL after 1 hour ΔL after 3 hours Experimental Example 1 After removing the release film from the patch prepared by the method of Example 15 and loading 0.5 g of the whitening gel prepared by the method of Example 1 into the storage tank (reservoir), the reservoir was allowed to contact the specimen, and then the change in L value was measured. did. 35.5 ± 4.3 43.8±5.1 Experimental Example 2 After removing the release film from the patch prepared by the method of Example 11 and loading 0.5 g of the whitening gel prepared by the method of Example 1 into the reservoir, the reservoir was allowed to contact the specimen, and then the change in L value was measured. 37.4 ± 3.9 44.2 ± 4.5 Experimental Example 3 After removing the release film from the patch prepared by the method of Example 12 and loading 0.5 g of the whitening gel prepared by the method of Example 2 into the reservoir, the reservoir was allowed to contact the specimen, and then the change in L value was measured. 33.6 ± 5.8 39.6 ± 4.6 Experimental Example 4 After removing the release film from the patch prepared by the method of Example 15 and loading 0.5 g of the whitening gel prepared by the method of Example 3 into the reservoir, the reservoir was allowed to contact the specimen, and then the change in L value was measured. 40,8 ± 4.5 44.9 ± 5.1 Comparative Example 2 After removing the release film from the patch prepared by the method of Comparative Example 1 and loading 0.5 g of the whitening gel prepared by the method of Example 1 into the reservoir, the reservoir was allowed to contact the specimen, and then the change in L value was measured. 21.3 ± 4.3 26.6 ± 6.2

[Experimental Example 5] Irritation improvement

After injecting (loading) the whitening formulation containing the tooth whitening effect main ingredient into the patch storage tank (reservoir), and attaching it to the teeth, the irritation at the attached site was evaluated. After attaching the patch to the teeth, the case where there was no stimulation at all was set to 0, and the case where the stimulation was too strong to be attached was set to 10, and 10 subjects were tested for irritation. The results are shown in Table 7 below.

subject Irritation index immediately after application Irritation index after 5 minutes Experimental Example 1 Comparative Example 2 Experimental Example 1 Comparative Example 2 Subject 1 2 6 One 2 Subject 2 3 5 0 One Subject 3 3 6 2 2 Subject 4 4 7 One 3 Subject 5 One 6 2 One Subject 6 2 6 2 2 Subject 7 5 8 One One Subject 8 4 8 One 3 Subject 9 3 7 0 2 Subject 10 2 7 One One average 2.9 ± 1.2 6.6 ± 1.0 1.1 ± 0.7 1.8 ± 0.8

Claims (20)

A patch kit for teeth whitening, comprising:
The kit includes a patch, and a solution or gel,
The patch may include an adhesive layer attached to the tooth; and
In contact with a portion of the surface attached to the tooth of the adhesive layer, comprising a reservoir capable of impregnating a liquid or gel,
The liquid or gel contains a tooth whitening component,
Injecting the liquid or gel into the reservoir when using the kit,
Reservoir type tooth whitening patch kit. The method of claim 1,
A tooth whitening patch kit in which the surface of the adhesive layer attached to the teeth is protected with a release paper. The method of claim 1,
The tooth whitening component is a tooth whitening patch kit comprising hydrogen peroxide. 4. The method of claim 3,
The tooth whitening component further comprises one or more selected from the group consisting of polyvinyl alcohol, polyvinyl pyrrolidone and sodium carboxymethyl cellulose. 4. The method of claim 3,
The tooth whitening component is a tooth whitening patch kit further comprising a stabilizer. 6. The method of claim 5,
The stabilizer is sodium stearate, sodium pyrophosphate, phenacetin, zirconium oxychloride and one or more tooth whitening patch kit selected from the group consisting of laponite. The method of claim 1,
The tooth whitening component is a tooth whitening patch kit in a liquid or gel formulation having a viscosity of 100 to 10,000 cps. The method of claim 1,
The reservoir is at least one tooth whitening patch kit selected from the group consisting of natural or synthetic nonwoven fabrics, natural or synthetic woven fabrics, hydrophilic modified fibers and urethane-based foams of natural or synthetic nonwoven fabrics. The method of claim 1,
The reservoir is a tooth whitening patch kit that can be impregnated with a liquid or gel 1 to 30 times the weight of the reservoir itself. The method of claim 1,
The reservoir is a tooth whitening patch kit having a thickness of 0.01 to 5 mm. The method of claim 1,
The reservoir is a tooth whitening patch kit further comprising a hydrogen peroxide activator. 12. The method of claim 11,
The hydrogen peroxide activator is at least one tooth whitening patch kit selected from the group consisting of sodium hydroxide, sodium bicarbonate and sodium percarbonate. The method of claim 1,
The adhesive layer is a tooth whitening patch kit made of at least one of a hydrophilic polymer and a crosslinkable water-soluble polymer. The method of claim 1,
The adhesive layer is cellulose gum, hydroxypropyl methylcellulose, hydroxyethyl cellulose, sodium acrylate, polyacrylic acid, polyvinylpyrrolidone, polyvinyl alcohol, polyacrylate crosspolymer, aminomethacrylic copolymer, methacryl acid A tooth whitening patch kit comprising at least one selected from the group consisting of ethyl acrylate copolymer, sodium polyacrylate, and acrylate copolymer containing acrylic acid as a monomer. 15. The method of claim 14,
The adhesive layer is a tooth whitening patch kit further comprising at least one selected from the group consisting of glycerin, butylene glycol and ethylene glycol. The method of claim 1,
The adhesive layer is a tooth whitening patch kit having a thickness of 10 to 500㎛. The method of claim 1,
The adhesive layer is a tooth whitening patch kit further comprising a support. 18. The method of claim 17,
The support is one or more films selected from the group consisting of polyethylene, polyester, polypropylene, urethane, and ethylene vinyl acetate, a tooth whitening patch kit. A tooth whitening method using the tooth whitening patch kit according to any one of claims 1 to 18. 20. The method of claim 19,
The tooth whitening method is a tooth whitening method of attaching the adhesive layer to the teeth after injecting the tooth whitening component of the separate liquid or gel into the storage tank.