KR20040018328A - 히스톤 디아세틸라제-4를 특이적으로 억제하는 방법 - Google Patents

히스톤 디아세틸라제-4를 특이적으로 억제하는 방법 Download PDF

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Publication number
KR20040018328A
KR20040018328A KR10-2003-7009362A KR20037009362A KR20040018328A KR 20040018328 A KR20040018328 A KR 20040018328A KR 20037009362 A KR20037009362 A KR 20037009362A KR 20040018328 A KR20040018328 A KR 20040018328A
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KR
South Korea
Prior art keywords
hdac
optionally substituted
alkylene
group
antisense oligonucleotide
Prior art date
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KR10-2003-7009362A
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English (en)
Korean (ko)
Inventor
제프리 엠. 베스터만
클레어 본필즈
순형 우
아카디이 배부르그
다니엘 디롬므
마리엘 프루넬
리코 라보에
주오메이 리
Original Assignee
메틸진, 인크.
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Application filed by 메틸진, 인크. filed Critical 메틸진, 인크.
Publication of KR20040018328A publication Critical patent/KR20040018328A/ko

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01098—Histone deacetylase (3.5.1.98), i.e. sirtuin deacetylase
    • A—HUMAN NECESSITIES
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR10-2003-7009362A 2001-01-12 2002-01-14 히스톤 디아세틸라제-4를 특이적으로 억제하는 방법 KR20040018328A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26152201P 2001-01-12 2001-01-12
US26167401P 2001-01-12 2001-01-12
US60/261,674 2001-01-12
US60/261,522 2001-01-12
PCT/IB2002/002002 WO2002069947A2 (fr) 2001-01-12 2002-01-14 Procede permettant d'inhiber specifiquement l'histone deacetylase-4

Publications (1)

Publication Number Publication Date
KR20040018328A true KR20040018328A (ko) 2004-03-03

Family

ID=26948670

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7009362A KR20040018328A (ko) 2001-01-12 2002-01-14 히스톤 디아세틸라제-4를 특이적으로 억제하는 방법

Country Status (6)

Country Link
JP (1) JP2004520421A (fr)
KR (1) KR20040018328A (fr)
CA (1) CA2434601A1 (fr)
DE (1) DE10295684T9 (fr)
GB (1) GB2389365A (fr)
WO (1) WO2002069947A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851173A (zh) 2001-09-14 2010-10-06 梅特希尔基因公司 组蛋白脱乙酰化酶抑制剂
US7868204B2 (en) 2001-09-14 2011-01-11 Methylgene Inc. Inhibitors of histone deacetylase
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
GB0226855D0 (en) 2002-11-18 2002-12-24 Queen Mary & Westfield College Histone deacetylase inhibitors
CA2528003A1 (fr) * 2003-06-10 2004-12-23 Kalypsys, Inc. Composes carbonyle utilises comme inhibiteurs de l'histone desacetylase a des fins therapeutiques
US7271195B2 (en) 2003-06-10 2007-09-18 Kalypsys, Inc. Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease
WO2005030704A1 (fr) 2003-09-24 2005-04-07 Methylgene, Inc. Inhibiteurs d'histone deacetylase
EP1574213B1 (fr) * 2004-03-11 2008-07-09 Asan Laboratories Company (Cayman), Limited Usage d'inhibiteurs de l'histone déacétylase pour augmenter l'action thérapeutique en radiotherapie et chemothérapie
US7253204B2 (en) 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
WO2006063294A2 (fr) * 2004-12-09 2006-06-15 Kalypsys, Inc. Nouveaux inhibiteurs de l'histone deacetylase permettant de traiter une maladie
GB0509223D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Enzyme inhibitors
GB0509225D0 (en) 2005-05-05 2005-06-15 Chroma Therapeutics Ltd Inhibitors of enzymatic activity
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
GB0518237D0 (en) 2005-09-07 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
CA2648804C (fr) 2006-04-07 2014-05-27 Methylgene Inc. Derives de benzamide utilises en tant qu'inhibiteurs de l'histone desacetylase
GB0619753D0 (en) 2006-10-06 2006-11-15 Chroma Therapeutics Ltd Enzyme inhibitors
GB0620823D0 (en) 2006-10-19 2006-11-29 Univ London Histone deacetylase inhibitors
JP5043120B2 (ja) 2006-10-30 2012-10-10 クロマ セラピューティクス リミテッド ヒストンデアセチラーゼの阻害剤としてのヒドロキサメート
US8030344B2 (en) 2007-03-13 2011-10-04 Methylgene Inc. Inhibitors of histone deacetylase
GB0903480D0 (en) 2009-02-27 2009-04-08 Chroma Therapeutics Ltd Enzyme Inhibitors
US9636298B2 (en) 2014-01-17 2017-05-02 Methylgene Inc. Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
ES2228119T3 (es) * 1998-10-19 2005-04-01 Methylgene, Inc. Modulacion de la expresion de la adn-metil-tranferasa mediante terapia de combinacion.
EP1173562A2 (fr) * 1999-05-03 2002-01-23 Methylgene, Inc. Inhibition d'histone deacetylase

Also Published As

Publication number Publication date
CA2434601A1 (fr) 2002-09-12
GB2389365A (en) 2003-12-10
JP2004520421A (ja) 2004-07-08
DE10295684T1 (de) 2003-11-20
DE10295684T9 (de) 2004-10-14
WO2002069947A2 (fr) 2002-09-12
GB0316313D0 (en) 2003-08-13
WO2002069947A3 (fr) 2003-10-09

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