KR20040014500A - 생물발효 시스템에서 사용하기 위한 생성물 제거 방법 - Google Patents

생물발효 시스템에서 사용하기 위한 생성물 제거 방법 Download PDF

Info

Publication number
KR20040014500A
KR20040014500A KR10-2003-7013629A KR20037013629A KR20040014500A KR 20040014500 A KR20040014500 A KR 20040014500A KR 20037013629 A KR20037013629 A KR 20037013629A KR 20040014500 A KR20040014500 A KR 20040014500A
Authority
KR
South Korea
Prior art keywords
biocatalyst
biofermentation
water
target molecule
free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR10-2003-7013629A
Other languages
English (en)
Korean (ko)
Inventor
앙투아네트 이. 윌킨스
데이비드 제이. 로우
Original Assignee
이 아이 듀폰 디 네모아 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이 아이 듀폰 디 네모아 앤드 캄파니 filed Critical 이 아이 듀폰 디 네모아 앤드 캄파니
Publication of KR20040014500A publication Critical patent/KR20040014500A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02—Percolation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR10-2003-7013629A 2001-04-20 2002-04-22 생물발효 시스템에서 사용하기 위한 생성물 제거 방법 Ceased KR20040014500A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28555501P 2001-04-20 2001-04-20
US60/285,555 2001-04-20
PCT/US2002/012606 WO2002086135A2 (en) 2001-04-20 2002-04-22 A product removal process for use in a biofermentation system

Publications (1)

Publication Number Publication Date
KR20040014500A true KR20040014500A (ko) 2004-02-14

Family

ID=23094748

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2003-7013629A Ceased KR20040014500A (ko) 2001-04-20 2002-04-22 생물발효 시스템에서 사용하기 위한 생성물 제거 방법

Country Status (10)

Country Link
US (2) US6812000B2 (enExample)
EP (1) EP1379673A4 (enExample)
JP (1) JP4261196B2 (enExample)
KR (1) KR20040014500A (enExample)
CN (1) CN1250733C (enExample)
AU (1) AU2002252704A1 (enExample)
BR (1) BR0209081A (enExample)
CA (1) CA2441774A1 (enExample)
MX (1) MXPA03009552A (enExample)
WO (1) WO2002086135A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100366730C (zh) 2002-04-22 2008-02-06 纳幕尔杜邦公司 用于遗传工程的启动子和质粒系统
US7229554B2 (en) * 2002-09-25 2007-06-12 Novo Nordisk A/S Purification process comprising microfiltration at elevated temperatures
EP1546304B1 (en) * 2002-10-04 2013-05-08 Danisco US Inc. Improved production of bacterial strains
ATE493490T1 (de) * 2002-10-04 2011-01-15 Du Pont Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute
US20080178581A1 (en) * 2007-01-19 2008-07-31 Juon Co., Ltd. Utilizing biomass
US8609385B2 (en) 2007-05-01 2013-12-17 Zuvachem, Inc. Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
EP2014760A1 (en) * 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
GB2457820B (en) * 2008-02-28 2010-09-08 Green Biologics Ltd Production process
US20100264094A1 (en) * 2009-04-16 2010-10-21 Kent Bioenergy Corporation Method of developing a rapidly settling algal floc
CN102459138A (zh) 2009-06-04 2012-05-16 基因组股份公司 分离发酵液成分的方法
US8658845B2 (en) 2012-05-23 2014-02-25 Orochem Technologies, Inc. Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system
US8704016B2 (en) 2012-05-23 2014-04-22 Orochem Technologies, Inc. SMB process for the purification of ethanol and butanediol with integrated regeneration
DK2976418T3 (da) 2013-03-19 2021-01-11 Cmc Biologics As Fremgangsmåde til fremstilling af et produkt (f.eks. polypeptid) i en kontinuerlig cellekulturfermenteringsproces
EP3280697A1 (en) 2015-04-08 2018-02-14 INVISTA Textiles (U.K.) Limited Materials and methods for the selective recovery of monovalent products from aqueous solutions using continuous ion exchange
WO2016164767A1 (en) 2015-04-10 2016-10-13 Invista North America S.A.R.L. Process for separation of diamines and/or omega-aminoacids from a feed mixture
CN113015578B (zh) 2018-09-18 2023-11-21 英威达纺织（英国）有限公司 用于从水性混合物中回收胺及其衍生物的系统和方法
CA3167811A1 (en) * 2020-02-11 2021-08-19 Arbela Laboratories, Inc. Integrated methanol synthesis and fermentation system
EP4124653A1 (en) 2021-07-27 2023-02-01 Sartorius Stedim Biotech GmbH Method for producing a bioproduct
AU2022325485A1 (en) * 2021-08-13 2024-03-21 Bluetech Aps Industrial method for isolating an analyte from a liquid mixture

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135853A (en) * 1983-07-22 1992-08-04 Rensselaer Polytechnic Institute Three compartment bioreactor and method of use
US4851573A (en) 1986-12-18 1989-07-25 Uop Separation of citric acid from fermentation broth with a weakly basic anionic exchange resin adsorbent
EP0361082A3 (de) 1988-09-01 1991-09-18 Henkel KGaA Fermentative Herstellung von 1,3-Propandiol
WO1991002049A1 (en) * 1989-08-04 1991-02-21 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
JP3018449B2 (ja) * 1990-09-21 2000-03-13 味の素株式会社 アミノ酸の発酵方法およびその装置
IT1247995B (it) * 1991-06-06 1995-01-05 Himont Inc Processo per la produzione di soluzioni acquose di acido lattico purificate a partire da brodi di fermentazione.
FI96225C (fi) * 1993-01-26 1996-05-27 Cultor Oy Menetelmä melassin fraktioimiseksi
FI98791C (fi) * 1994-04-21 1997-08-25 Xyrofin Oy Menetelmä liuoksen fraktioimiseksi
US5795398A (en) * 1994-09-30 1998-08-18 Cultor Ltd. Fractionation method of sucrose-containing solutions
US6146534A (en) * 1996-08-19 2000-11-14 Reilly Industries, Inc. Thermally-managed separation and dewatering processes for recovering acid products
US6224776B1 (en) * 1996-05-24 2001-05-01 Cultor Corporation Method for fractionating a solution
FI962204A0 (fi) 1996-05-24 1996-05-24 Cultor Oy Foerfarande foer fraktionering av en loesning
DE29611336U1 (de) * 1996-06-28 1996-09-19 Gesellschaft für Biotechnologische Forschung mbH (GBF), 38124 Braunschweig Filtrationsvorrichtung
AU6043598A (en) * 1997-01-29 1998-08-18 Amalgamated Research, Inc. Method of displacement chromatography
US6106723A (en) * 1997-02-10 2000-08-22 Grandics; Peter Method for removing pyrogens from dialysate
US6114157A (en) 1998-09-25 2000-09-05 General Electric Company Method for increasing total production of 4-hydroxybenzoic acid by biofermentation
GB9826684D0 (en) 1998-12-04 1999-01-27 Alpharma As Process for the purification of compounds by means of simulated moving bed (smb) chromatography
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
US6603048B1 (en) 1999-10-05 2003-08-05 E. I. Du Pont De Nemours And Company Process to separate 1,3-propanediol or glycerol, or a mixture thereof from a biological mixture
US6995246B1 (en) * 2000-10-19 2006-02-07 Akzo Nobel N.V. Methods for removing suspended particles from soluble protein solutions
FI20010977A7 (fi) * 2001-05-09 2002-11-10 Danisco Sweeteners Oy Kromatografinen erotusmenetelmä
US6872314B2 (en) * 2003-08-29 2005-03-29 Eastman Chemical Company Dewatering process

Also Published As

Publication number Publication date
EP1379673A2 (en) 2004-01-14
US7166460B2 (en) 2007-01-23
CA2441774A1 (en) 2002-10-31
US20030166040A1 (en) 2003-09-04
US6812000B2 (en) 2004-11-02
HK1066568A1 (en) 2005-03-24
EP1379673A4 (en) 2006-02-15
WO2002086135A3 (en) 2003-02-13
JP2004524852A (ja) 2004-08-19
JP4261196B2 (ja) 2009-04-30
US20050208615A1 (en) 2005-09-22
WO2002086135A2 (en) 2002-10-31
MXPA03009552A (es) 2004-02-12
AU2002252704A1 (en) 2002-11-05
CN1250733C (zh) 2006-04-12
BR0209081A (pt) 2004-06-22
CN1503846A (zh) 2004-06-09

Similar Documents

Publication Publication Date Title
US7166460B2 (en) Product removal process for use in a biofermentation system
Xiu et al. Present state and perspective of downstream processing of biologically produced 1, 3-propanediol and 2, 3-butanediol
Li et al. Aqueous two-phase extraction of 1, 3-propanediol from glycerol-based fermentation broths
Etschmann et al. Production of 2‐phenylethanol and 2‐phenylethylacetate from L‐phenylalanine by coupling whole‐cell biocatalysis with organophilic pervaporation
CN103987852B (zh) 2,3‑丁二醇的制造方法
EA029944B1 (ru) Ферментация и способ с псевдодвижущимся слоем
KR100713762B1 (ko) 생물학적 혼합물로부터 1,3-프로판디올 또는 글리세롤,또는 그의 혼합물의 분리 방법
CA2220396C (en) Process for making 1,3-propanediol from carbohydrates using mixed microbial cultures
US20100204526A1 (en) Process for solvent production utilizing liquid phase adsorption
Salas‐Villalobos et al. In situ product recovery as a strategy for bioprocess integration and depletion of inhibitory products
EP3533862B1 (en) Methylopila sp. and use thereof in selective resolution and preparation of (s)-alpha-ethyl-2-oxo-1 -pyrrolidine acetate
CA2783432A1 (en) Method for recovery of organic components from dilute aqueous solutions
Shu et al. Enhanced bioconversion of L‐phenylalanine into 2‐phenylethanol via an oxygen control strategy and in situ product recovery
Hou-Rui Key drivers influencing the large scale production of xylitol
CN105793429B (zh) 2,3-丁二醇的制造方法
van der Wielen et al. Integrated product formation and recovery in fermentation
Kalisa et al. Current trends in efficient production of 1, 3-propanediol
Matsumura et al. Enantioselective Production of (S)-3-Hydroxybutyric Acid,(S)-1, 3-Butanediol and (R)-1, 3-Butanediol Using Methanol Yeast.
JP2016077262A (ja) ２，３−ブタンジオールの製造方法
WO2025129053A9 (en) Methods and compositions for bioproduction of phloroglucinol
HK1050676A (en) Process to separate 1,3-propanediol or glycerol, or a mixture thereof from a biological mixture

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20031017

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20070209

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20071214

Patent event code: PE09021S01D

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20080723

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20090422

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20080723

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

Patent event date: 20071214

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I