KR20030068696A - 스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 - Google Patents
스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 Download PDFInfo
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- KR20030068696A KR20030068696A KR1020020008272A KR20020008272A KR20030068696A KR 20030068696 A KR20030068696 A KR 20030068696A KR 1020020008272 A KR1020020008272 A KR 1020020008272A KR 20020008272 A KR20020008272 A KR 20020008272A KR 20030068696 A KR20030068696 A KR 20030068696A
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- South Korea
- Prior art keywords
- stat3
- stem cells
- transplantation
- cells
- engraftment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
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- Health & Medical Sciences (AREA)
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Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020008272A KR20030068696A (ko) | 2002-02-15 | 2002-02-15 | 스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 |
| AU2003245073A AU2003245073A1 (en) | 2002-02-15 | 2003-02-17 | Stat3 activated stem cell |
| KR1020047012711A KR101027288B1 (ko) | 2002-02-15 | 2003-02-17 | 스탓3 활성화 줄기세포 |
| PCT/IB2003/000515 WO2003068952A1 (en) | 2002-02-15 | 2003-02-17 | Stat3 activated stem cell |
| JP2003568067A JP4834291B2 (ja) | 2002-02-15 | 2003-02-17 | Stat3活性化幹細胞 |
| US10/369,053 US7510870B2 (en) | 2002-02-15 | 2003-02-18 | STAT3 activated stem cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020020008272A KR20030068696A (ko) | 2002-02-15 | 2002-02-15 | 스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20030068696A true KR20030068696A (ko) | 2003-08-25 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020020008272A Pending KR20030068696A (ko) | 2002-02-15 | 2002-02-15 | 스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 |
| KR1020047012711A Expired - Fee Related KR101027288B1 (ko) | 2002-02-15 | 2003-02-17 | 스탓3 활성화 줄기세포 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047012711A Expired - Fee Related KR101027288B1 (ko) | 2002-02-15 | 2003-02-17 | 스탓3 활성화 줄기세포 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7510870B2 (https=) |
| JP (1) | JP4834291B2 (https=) |
| KR (2) | KR20030068696A (https=) |
| AU (1) | AU2003245073A1 (https=) |
| WO (1) | WO2003068952A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101322889B1 (ko) * | 2004-08-16 | 2013-10-30 | 셀리서치 코포레이션 피티이 리미티드 | 제대의 양막으로부터 줄기/전구세포의 추출 |
| US7838503B2 (en) * | 2005-06-15 | 2010-11-23 | Children's Medical Center Corporation | Methods for extending the replicative lifespan of cells |
| WO2007030693A2 (en) * | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| AU2008289209A1 (en) * | 2007-08-16 | 2009-02-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| US8445517B2 (en) | 2009-12-11 | 2013-05-21 | Dana-Farber Cancer Institute | Stat modulators |
| EP2630232A4 (en) * | 2010-10-22 | 2014-04-02 | Biotime Inc | METHOD FOR MODIFYING TRANSCRIPTIONAL REGULATORY NETWORKS IN STEM CELLS |
| WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
| US20190127700A1 (en) * | 2016-04-06 | 2019-05-02 | The Catholic University Of Korea Industry-Academic Cooperation Foundation | Technique for Enhancing Stem Cell Regeneration Through Interaction of Vascular Endothelial Cell and Mesenchymal Stem Cell |
| US20210222128A1 (en) * | 2020-01-22 | 2021-07-22 | Massachusetts Institute Of Technology | Inducible tissue constructs and uses thereof |
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| US4645791A (en) * | 1985-06-24 | 1987-02-24 | Ford Motor Company | Environmentally durable elastomer composition with excellent low temperature dynamic properties |
| US6235873B1 (en) * | 1999-07-31 | 2001-05-22 | The Rockefeller University | Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes |
-
2002
- 2002-02-15 KR KR1020020008272A patent/KR20030068696A/ko active Pending
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2003
- 2003-02-17 KR KR1020047012711A patent/KR101027288B1/ko not_active Expired - Fee Related
- 2003-02-17 AU AU2003245073A patent/AU2003245073A1/en not_active Abandoned
- 2003-02-17 JP JP2003568067A patent/JP4834291B2/ja not_active Expired - Fee Related
- 2003-02-17 WO PCT/IB2003/000515 patent/WO2003068952A1/en not_active Ceased
- 2003-02-18 US US10/369,053 patent/US7510870B2/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| Annu.Rev.Biomed.Eng., Peter W.Zandstra et al., 2001, Vol.3, p.275-305 * |
| Proc.Natl.Acad.Sci.USA, Regina Raz et al., 1999, Vol.96, p.2846-2851 * |
| The EMBO Journal, Takahiko Matsuda et al., 1999, 18(15),p.4261-4269 * |
Also Published As
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|---|---|
| US20030157711A1 (en) | 2003-08-21 |
| JP2005517404A (ja) | 2005-06-16 |
| KR20040084918A (ko) | 2004-10-06 |
| JP4834291B2 (ja) | 2011-12-14 |
| WO2003068952A1 (en) | 2003-08-21 |
| KR101027288B1 (ko) | 2011-04-06 |
| AU2003245073A1 (en) | 2003-09-04 |
| US7510870B2 (en) | 2009-03-31 |
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