KR20030021991A - Acne Remedies - Google Patents

Acne Remedies Download PDF

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KR20030021991A
KR20030021991A KR1020010056028A KR20010056028A KR20030021991A KR 20030021991 A KR20030021991 A KR 20030021991A KR 1020010056028 A KR1020010056028 A KR 1020010056028A KR 20010056028 A KR20010056028 A KR 20010056028A KR 20030021991 A KR20030021991 A KR 20030021991A
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acne
weight
skin
dried
treatment
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이덕중
이서익
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이덕중
이서익
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

PURPOSE: An agent for treatment of acne containing an extract of Hibiscus syriacus L., Caryophylli Flos and Cimicifugae Rhizoma as a main component is provided which has an excellent effect in treatment of acne by oral administration thereof in the shape of a capsule, tablet or granule, or applying to a lesion. CONSTITUTION: Selected Hibiscus syriacus L., Caryophylli Flos, Glycyrrhizae Radix and Cimicifugae Rhizoma are dried, ground and added with 40 to 50% by weight of citric acid or organic acid. Next, the mixture is swelled in 50 to 60% by weight of distilled water of a pH of 5.5 to 6.5 and dried after flash sterilization at 90deg.C or more, or concentrated under reduced pressure after controlling a pH of the filtrate.

Description

여드름 치료제{omitted}Acne Treatment

본 발명은 여드름을 예방하거나 치료를 위한 유용한 신규의 여드름 치료제 조성물에 관한 것이다.The present invention relates to novel acne therapeutic compositions useful for preventing or treating acne.

본 발명에 따르면 무궁화, 정향, 승마, 감초 등으로부터 유효성분을 추출, 이를 비누, 또는 화장료 그리고 기타 정제나 캡슐 형태 등으로 혼입할 수 있는 것을 제공함에 있다.According to the present invention is to extract the active ingredient from rose of sharon, cloves, horse riding, licorice, and the like, which can be incorporated in the form of soap or cosmetics and other tablets and capsules.

이는 피부에 혈액순환을 도우며 세균과 곰팡이를 소멸시키는 각종 유효성분이 함유되어 있으며, 세균에 의한 피부의 변질과 노화를 방지하고 피부에 산소호흡의 장애가 되는 현상을 줄여 줌으로서 이를 화장료 또는 비누화 하여 피부를 세척 하거나 복용함으로 근원적으로 여드름 현상을 예방 또는 치료해주는 것을 알아, 본 발명을 완성했다. 이러한 여드름은 유전성과 후천적으로는 약물 부작용 또는 정신적 스트레스 등에도 기인하며, 대개 사춘기가 되면 남성호르몬 분비가 왕성해져 모낭 옆 피지선을 자극하여 많은 피지가 분비되어 모공 입구까지 쌓여 마침내 모낭내에 세균서식을 도와 염증으로 까지 발전 되기도 한다.It contains various active ingredients that help blood circulation and extinguish bacteria and fungi. It prevents deterioration and aging of the skin caused by bacteria and reduces the phenomenon of oxygen breathing on the skin, which makes it skin or cosmetic. The present invention has been found to prevent or treat acne phenomena by washing or taking. This acne is caused by heredity and acquired drug side effects or mental stress.In puberty, male hormone secretion is vigorous and stimulates sebaceous glands next to the hair follicles, which secrete a lot of sebum and accumulate to the pores and finally help to grow bacteria in the hair follicles It may even develop into inflammation.

따라서 본 발명의 목적은 무궁화, 정향, 감초, 승마에서 추출한 유효성분으로 얼굴 등 피부에 돌출되는 여드름을 예방 또는 치료를 위한 신규의 여드름 치료제 조성물을 제공 하기 위한 것이다.Therefore, an object of the present invention is to provide a novel acne therapeutic composition for preventing or treating acne protruding to the skin, such as the face with the active ingredient extracted from Rose of Sharon, cloves, licorice, horse riding.

1) 정향나무 꽃봉오리에는 정유가 10% , 카리오필링 1.5% , 탄닌(Tannin) 12% , 수분 60∼70% 그 빡에 지방과 밀 , 미량의 바닐린(Vanillin) , 매틸 살리실레이트(Methylsaliclate) , 오레아노릭산(Oleanolicacid) 등이 포함 되었다.1) Clove buds contain 10% essential oil, 1.5% caryo peeling, 12% tannin, 60-70% moisture, and a small amount of fat and wheat, trace amounts of vanillin, and methyl saliclate (Methylsaliclate). , Orleanolic acid.

다시 말하면 정향꽃봉오리의 유효성분중에는 연누른색의 투명한 정유(精油)가 다량포함되어 있고 이들중 에우게놀(Eugenol) 은 피부에 병원균을 소멸 시켜 습진 , 기타 진균등에 생기는 피부의 변질 즉, 피부에 2차 감염된 미생물 , 페니실리움 노우티움(Penicillum chrysogen) , 리조푸스 자바니쿠 (Rnizi-pus javaicus) , 아스페로지루스우사미 (Aspergillus usami) , 아스페리지루스 아우아모리 (Aspergillus awa) , 아스페리지루스 니이그 (Aspergillus niger) 등의 활동으로 인한 생리적 각질퇴화(角質退化)의 가중을 줄여 피부의 노화를 방지하고 여드름 생성을 효과 적으로 억제함으로서 한편으로 피부외부의 원활한 산소호흡이 이뤄져, 진피내 모낭(Hair folli) 주위 미세혈관에 헤모글로빈 동화작용의 활성을 주어 여드름 예방 및 치료에 도움이 되어 진다고 본다.In other words, the active ingredient of the clove bud contains a lot of light yellow transparent essential oils, among which Eugenol extinguishes pathogens on the skin, resulting in the degeneration of the skin caused by eczema and other fungi. Secondary infected microorganisms, Penicillum chrysogen, Rnizi-pus javaicus, Aspergillus usami, Aspergillus aamori, Asperridge By reducing the weight of physiological keratinization caused by activities such as Aspergillus niger, it prevents the aging of the skin and effectively suppresses the formation of acne, while smoothly breathing oxygen outside the skin. Hemoglobin assimilation to hair follicles (Hair folli) by the activity of hemoglobin is believed to help prevent and treat acne.

한편 , 이러한 진균서식 등의 억제를 위한 기능은 동의보감 문헌에도 확인이 된다.On the other hand, the function for suppressing such fungal forms, etc. can also be confirmed in the consent book.

"이 약을 먹음으로 장을 맑게 하고 신장(賢臟)에 기를 살리며, 잇몸이 헐어 곪는 병이나 구취(口臭)를 제거 한다." 하여 무엇보다도 복용가능함 과 인체에 독성이 없음을 잘 알 수 있고 또한 세포에 해로운 병원균을 소멸시킬 수 있는 효능이함유되어 있다는 것을 알 수 있다."By taking this medicine to clear the intestines and kidneys (賢 臟) to save the qi, the gums torn down or remove the bad breath (口臭)." First of all, it can be seen that it is possible to take it and is not toxic to the human body, and also has the effect of extinguishing pathogens harmful to cells.

(참고문헌) 동의보감 탕액 3 편 p 1220(Ref.) Consensus Relief Liquid Part 3 p 1220

2) 감초에는 단맛이 나고 특이한 냄새가 나며 껍질이 붙은 바깥면에는 세로의 피목이 있고 암갈색 암적갈색을 나타내는 것으로써, 중국이 원산이고 우리나라, 일본에도 많이 재배되며 이는 섬유성이고 세로로 갈라지기 쉽다.2) Licorice has a sweet, peculiar smell, and the outer surface of the skin has a vertical cortex and dark brown dark reddish brown color. It is native to China and cultivated in Korea and Japan, which is fibrous and easily cracked vertically. .

감초의 단면에는 글리시리진(Glycyrrhizin) , 글라브릭산(Glabricacid) , 우라렉닉 산(Uralenic acid) 등 유효성분이 있으며 그 밖에 항염증작용 , 항알레르기(Allergy)작용, 항바이러스(Virus) 작용을 하는 성분 등이 함유되어 있음.The licorice cross section contains active ingredients such as glycyrrhizin, glabricacid, and uralenic acid.In addition, anti-inflammatory, anti-allergic, anti-viral, etc. Contains

(참고문헌)(references)

1.Yahara. s , and Nishioka , 1 : phytocb m 23 , 2108 (1984)1.Yahara. s, and Nishioka, 1: phytocb m 23, 2108 (1984)

2. Kambayashi , K , et al : phytochem. 24 , 339 (1985)2. Kambayashi, K, et al: phytochem. 24, 339 (1985)

3. Segal, R., et al : J. pharm. sci, 74, 79(1985)3. Segal, R., et al: J. pharm. sci, 74, 79 (1985)

3) 무궁화는 본 발명 이전에 이미 등록된 특허 제 086492호에 기술된 바, 무궁화는 그 성분이 혈중 콜레스토롤을 줄여 혈액순환을 도울 수 있는 인체에 유효하고 독성이 없는 것을 증명 한바 있고, 이러한 무궁화성분의 혈액순환을 도울 수 있는 작용이 말초신경조직 , 주위세포들의 진피층을 원활한 혈액순환을 도와 본 발명의 이러한 약재들과 함께 혼용시 여드름 치료에 상당한 효과를 또한 발견 할 수 있었다.3) Rose of sharon is described in Patent No. 086492 already registered before the present invention, Rose of Rose has proved that its components are effective and nontoxic to the human body, which can reduce blood cholesterol and help blood circulation, The action that can help the blood circulation of the green light component helped to smooth the blood circulation in the dermal layer of peripheral nerve tissue, surrounding cells, and when used together with these medicines of the present invention, a significant effect was also found in the treatment of acne.

4) 승마 또한 본 발명이 있기 이전 특허 출원 제 92-000428호에서 밝힌바,피부의 진균을 소멸시킬 수 있으며, 이미 당시 특허공보에 기록되어 있듯이 인체에도 무해함을 동의보감 등 자료를 제출 한 바 있으며, 이러한 승마를 본 약재들과 혼용시 비로서 탁월한 여드름 예방 및 치료의 효과를 발견 할 수 있었다.4) Horse riding also disclosed in the patent application No. 92-000428 before the present invention, can extinguish the fungus of the skin, and as already recorded in the patent publication at the time has submitted data such as consent and the sense of harm When mixed with these medicines, horse riding was found to be effective in preventing and treating acne.

무궁화 , 정향 , 감초 , 승마 각각 으로부터 증류수 , 메탄올 , 에탄올 또는 이를 혼합용매들로 하여 압출방식 , 원심분리방식 , 냉각콘덴샤방식등 여러 가지 방법이 있으며 이러한 방법들 중에서 유효성분의 추출효율을 높이기 위한 몇가지 예를 든다.Distilled water, methanol, ethanol, or mixed solvents from Mugunghwa, Clove, Licorice, Horseback Riding, etc. can be used for extrusion, centrifugal separation, cooling condensation, and so on. Give an example.

실시예 1.Example 1.

이등 각각의 재료들을 분리하여 세절 또는 분쇄하여 중량비로 40∼50%를 적당한 용기에 넣어 이들 재료의 유효성분이 쉽게 용출될 수 있게 하기 위해 레몬즙이나 구연산 또는 아미노산류 등을 첨가하여 산가 즉 , PH 5.5 ∼ 6.5로 조절된 물 50∼60%넣어 20∼25℃로 2~3일간 방치하여 습윤시킨 후 다시 70∼80℃로 40∼50분간 가열시키거나 90℃ 이상의 온도에서 순간 살균 , 소독한 후 , 이들을 건조기에 넣어 30∼40℃ 의 열을 송풍시키면서 건조시킨 후 이들 각각의 재료들을 유효성분이 쉽게 물에서 용출될 수 있게 만들어 이것을 다시 분쇄하여 정제수 또는 에탄올 등으로 압출식 또는 원심분리 , 냉각콘덴샤방식 등 으로 추출하는 방법.In order to separate and crush or crush each other, add 40 ~ 50% by weight in a suitable container so that the active ingredients of these materials can be easily eluted, add lemon juice, citric acid, amino acids, etc. 50 to 60% of the water adjusted to ˜6.5, and left to wet for 2 to 3 days at 20 to 25 ° C., followed by heating for 40 to 50 minutes at 70 to 80 ° C. or after instant sterilization and disinfection at a temperature of 90 ° C. or higher. After putting them in a dryer and drying them with blowing at a temperature of 30 to 40 ° C., each of these materials can be easily eluted from water, and then crushed again and then extruded or centrifuged with purified water or ethanol, cooling condensation, etc. How to extract it.

실시예 2.Example 2.

이들 각각의 재료들을 20∼30중량%를 용기에 닫고 0.5노르말암모니아수용 70∼80중량%에 넣고 약 30∼35℃에서 8∼9시간 방치 한 후, 프레스기나 원심분리기등에 투입하여 추출한 후 셀라이트 등으로 여과한다.20-30% by weight of each of these materials was placed in a container, 70-80% by weight of 0.5 normal ammonia, and left for 8-9 hours at about 30-35 ° C. Filtration with the back.

그리고 여액에 부칠알콜과 에칠아세테이트 를 (2:1) 혼합비로 교반 한 후 용기용매층이 맑아 질때 까지 셀라이트를 통해 반복해서 감압, 농축한다.After stirring the butyl alcohol and ethyl acetate in the (2: 1) mixing ratio in the filtrate, it is repeatedly reduced pressure and concentrated through celite until the container solvent layer is clear.

여기에 여과시 걸러진 찌꺼기를 에탄올 99.5%에 완전히 용해시킨 후 PH 6∼7.5로 조절한 묽은 수산화 나트륨수용액을 가해서 수분을 제거하고 여과시킨다.After filtering, the filtered residue was completely dissolved in 99.5% of ethanol, and diluted aqueous sodium hydroxide solution adjusted to PH 6-7.5 was added to remove water and filtered.

실시예 3.Example 3.

이들 각각의 재료들을 그늘에서 송풍기 혹은 저온의 열풍으로 건조하고 잘게 분쇄한 분쇄물 로 10∼20중량%를 용기에다 넣고 여기에다 수산화칼륨포화수용액 80∼90중량%를 가한 후 40∼45℃에서 7∼8시간 방치하여 압출식 등 방식으로 추출한 후 여과 한다.Each of these materials is put into a container by using a blower or a low temperature hot air dried in a shade and pulverized 10 to 20% by weight, and 80 to 90% by weight of saturated potassium hydroxide solution is added. It is left to stand for 8 hours, extracted by extrusion method, and filtered.

2차로 NaCl 포화용액과 (8:1) 교반한 후 묽은 염산 수용액으로 중화 한 후 PH 3∼4로 조절 하여 침전물을 여과시킨다.After stirring with saturated NaCl solution (8: 1) for 2 hours, neutralize with dilute hydrochloric acid solution and adjust to PH 3 ~ 4 to filter the precipitate.

3차로 이소프로필알콜-디메칠케톤을 (1:1) 비율로 교반 한 후 셀라이트 등으로 반복분리하여 추출 한 후 감압농축한다.Thirdly, isopropyl alcohol-dimethylmethyl is stirred at a ratio of (1: 1), extracted with celite, and extracted repeatedly, followed by concentration under reduced pressure.

마지막으로 농축 잔사를 메탄올에 용해시킨 후 수산화나트륨수용액으로 PH 6∼8로 조절 한 후 황산나트륨을 교반하여 34∼35℃에서 열에서 12 시간 밀폐된 상태에서 방치 한 후 여과한다.Finally, the concentrated residue was dissolved in methanol, adjusted to PH 6-8 with aqueous sodium hydroxide solution, and then stirred with sodium sulfate and left in a sealed state for 12 hours at 34-35 ° C., followed by filtration.

이를 다시 고농축 고농도로 정제된 추출물을 얻을 수 있으며 이와 같이 얻어진 추출액은 휴발시키고 감압농축하여 액기스화 하거나 열풍으로 분무건조하여 분말 또는 과립상 등 으로 만들어진 여드름 예방 및 치료에 탁월한 추출물을 수거 할수 있다.This extract can be obtained with high concentration and high concentration purified extract. The extract thus obtained can be rested and concentrated under reduced pressure to be extracted or spray-dried with hot air to collect excellent extracts for acne prevention and treatment made of powder or granules.

실시예 1에서 3까지의 방법등으로 추출된 여드름방지 및 치료에 유효한 추출물들은 과립이나 정제 또는 캡슐화 하여 복용할 수 도 있을 뿐 아니라 이들 여드름 예방 및 치료에 유효한 추출성분들을 액기스화 하여 피부에 직접 도포하거나 세정제 또는 비누등에 첨가 할 수 있는 획기적인 제품이다.Extracts effective for preventing and treating acne extracted by the methods of Examples 1 to 3 may be taken in granules, tablets or capsules, as well as directly applied to the skin by extracting the extract ingredients effective for preventing and treating acne. It is an innovative product that can be added to detergents or soaps.

(실시예 1. 임상실험)Example 1. Clinical Trial

이들 추출물을 복용하기 좋게 캡슐화 시켜 심한 가려움증과 함께 여드름이 진행되는 4명의 지성피부와 3명의 건성피부를 가진 자들을 대상으로 2개월간 조석으로 2회 복용 시험한 결과 표 1과 같았다.These extracts were encapsulated in good doses, and two doses of two-month tidal tests were conducted on those with four oily skin and three dry skin where acne progressed along with severe itching.

표 1.Table 1.

(실시예 2. 임상실험)Example 2. Clinical Trial

이들 추출물을 얼굴 피부에 도포하기 좋게 토닉화 하여 가려움과 함께 여드름이 진행되는 3 명의 지성피부와 3 명의 건성 피부를 가진 자 들을 대상으로 3 개월 간 조석으로 세면 후 피부에 가볍게 도포 시험한 결과 표 2와 같았다.These extracts were tonicized to be applied to the skin of the face, and three people with oily and acne-prone skin and three dry skins were washed with a tidal solution for three months. It was like

표 2.Table 2.

(실시예 3. 임상실험)(Example 3. Clinical Experiment)

이들 추출물을 얼굴이나 목 등에 세척하기 좋게 비누에 첨가,제조 하여 가려움증과 함께 여드름이 심하게 진행되는 4 명의 지성 피부와 3 명의 건성 피부를 가진 자들을 대상으로 2 개월간 조석으로 깨끗이 세면을 하면서 시험한 결과 표 3과 같았다.These extracts were added to soaps to clean the face and neck, and were prepared by washing them with tidal cleansing for 2 months for those with 4 oily and 3 dry skin that have severe acne and itching. It was as Table 3.

표 3.Table 3.

실시예 예1, 예2. 예3. 에서의 결과로도 알 수 있듯이 이들 추출물을 복용 또는 도포하거나 세제류에 혼용하여 사용하므로 여드름 치료에 탁월한 효과를 발견 할 수있었다.EXAMPLES Example 1, Example 2. Example 3. As can be seen from the results, these extracts were taken or applied, or used in combination with detergents, so they could find an excellent effect on the treatment of acne.

Claims (1)

정선한 무궁화 , 정향 , 감초 , 승마 이들을 각각 건조 , 분쇄하여 중량비로 40∼50%를 구연산 또는 유기산등을 첨가하여 산가 즉, PH 5.5∼6.5 로 조절된 증제수 50∼60%를 넣어 습윤시킨 후 90℃이상의 온도에서 순간 살균 후 건조시키거나 수산화칼륨 수용액 등 알카리 용액으로 PH 6∼8로 조절된 그 여액을 농축 감압시켜 액기스 , 분말 또는 과립상등으로 된 여드름 방지 및 여드름 치료제 조성물을 특징으로 한 제조방법.Selected Rose of Sharon, Cloves, Licorice, Horseback Riding and Drying of these, respectively, 40-50% by weight of citric acid or organic acid, etc. After the instant sterilization at a temperature of more than 90 ℃ dried or concentrated by reducing the filtrate adjusted to pH 6-8 with an alkaline solution such as potassium hydroxide aqueous solution, characterized in that the anti-acne and acne treatment composition consisting of extracts, powders or granules Way.
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010100129A (en) * 2001-10-09 2001-11-14 황병조 A method for producing a drug for athlete's foot from Pulsatilla koreana Nakai and flowers of Hibiscus syriacus and a drug for athelete's foot
WO2009036751A3 (en) * 2007-09-19 2009-06-04 Bionorica Ag Cosmetic or dermatological composition for topical application
WO2019107723A1 (en) * 2017-11-28 2019-06-06 주식회사 아모레퍼시픽 Composition for sebum control and pore minimizing
US11672753B2 (en) 2017-11-28 2023-06-13 Amorepacific Corporation Composition for sebum control and pore minimizing

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010100129A (en) * 2001-10-09 2001-11-14 황병조 A method for producing a drug for athlete's foot from Pulsatilla koreana Nakai and flowers of Hibiscus syriacus and a drug for athelete's foot
WO2009036751A3 (en) * 2007-09-19 2009-06-04 Bionorica Ag Cosmetic or dermatological composition for topical application
CN101883610A (en) * 2007-09-19 2010-11-10 比诺里卡股份有限公司 Cosmetic or dermatological composition for topical application
WO2019107723A1 (en) * 2017-11-28 2019-06-06 주식회사 아모레퍼시픽 Composition for sebum control and pore minimizing
US11672753B2 (en) 2017-11-28 2023-06-13 Amorepacific Corporation Composition for sebum control and pore minimizing

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