KR20020078709A - Composition for treating a acne vulgaris and method for fabricating the same - Google Patents

Abstract

PURPOSE: A process of preparing a composition for treating acne by extracting Chinese herbal medicine such as Glycyrrhizae Radix, Phellodendri Cortex, etc. is provided. Whereby, the composition has a keratosis and sebum-secretion inhibiting function as well as a dermatitis and acne bacteria removing function. CONSTITUTION: About 0.01 to 20 parts by weight of a herbal extract such as a burdock extract, 0.1 to 20 parts by weight of a Glycyrrhizae Radix extract and 0.1 to 20 parts by weight of Phellodendri Cortex are mixed with a specified amount of purified water followed by 1 to 50 parts by weight of alcohol and 0.001 to 1 part by weight of salicylic acid and then extracted.

Description

Composition for treating a acne and method for manufacturing the same {Composition for treating a acne vulgaris and method for fabricating the same}

The present invention relates to a composition for treating skin diseases, such as acne, and more particularly, "acne / bacteria", as well as acne treatment that can cope with and treat each other cause identified as the main mechanism of acne. It relates to a composition for. Moreover, the present invention relates to a manufacturing method for producing a composition for treating acne.

Recently, as the interest in skin care is rapidly increasing, various studies on skin diseases such as acne (Acne vulgaris) have been conducted.

As an example of such conventional studies, US Pat. No. 5019567, "Pharmaceutical and cosmetic compositions consisting of benzoyl peroxide, quaternary ammonium, lipophilic salicylic acid, and Benzoyl peroxide quaternary ammonium lipophilic salicylate based pharmaceutical and cosmetic compositions and their use especially in treatment of acne), for example, "can be treated acne through the antibacterial action of benzoyl peroxide", US Patent Publication No. 5554654 "Method of enhancing the therapeutic effect of anti-acne (Method for enhancing the therapeutic effect of an anti-acne agent) discloses, for example, that acne can be cured through the existing anti-wrinkle component, hydroxycarboxylic acids.

As another example, U.S. Patent No. 5621006, "Method for treating acne using benzilic acid," discloses, for example, that "acne can be treated using benzylic acid." , U.S. Patent No. 5690946, "Cosmetic and / or dermatological composition containing thermal spring water or mineral water and combat acne or aging" , US Patent No. 5997885 "Cosmetic and / or dermatological composition containing thermal spring water or mineral water and combat acne or aging" The back discloses that "acne can be cured by hot water."

In another example, U.S. Patent No. 5961993 "Composition containing a non-photocatalytic metal oxide and tocopherol its use in the treatment of acne" includes "tocopherol and Metal oxides can be used to treat acne, US Patent Publication No. 6168798 "Non-irritating composition for treating acne and other skin conditions." "It is possible to cure acne by using ingredients effective for anti-inflammatory and antibacterial" is disclosed.

As another example, U.S. Patent No. 5248503 "Herbal dietary supplement" and U.S. Patent No. 5869540 "Herbal treatments for improving skin appearance", for example, such as herbs (Herb) Can be used to treat acne. ”US Patent Publication No. 5716800“ Anti-acne composition containing a poria cocos wolf extract ”, US Patent Publication. US Pat. No. 6,183,747, "Use of plant momordica charactia extracts for treatment of acne acid," and the like, for example, can be used to treat acne.

In recent years, as research on acne has progressed rapidly, various factors, such as "inflammation of the skin", "acne bacteria such as bacteria", "skin abnormality", "excess of sebum", etc., are the main causes of acne. It turns out that it acts as a mechanism.

That is, it has been found that acne is not a "simple skin disease" caused by only one cause, but a "complex skin disease" caused by the interaction of each of the above-mentioned causes.

However, in spite of this situation, the above-mentioned conventional techniques, namely, the 5019567 patent, 5554654 patent, 5621006 patent, 5690946 patent, 5997885 patent, 5961993 patent, 5248503 patent, 5869540 patent, 5716800 patent, 6183747 patent, etc. However, since only the technical idea of targeting a specific pathogenesis of acne, for example, salt and antibacterial, is presented, in reality, only by using the above-mentioned conventional techniques, satisfactory acne treatment There are still many limitations to achieving the effect. In particular, in the case of the anti-inflammatory composition disclosed in the 6168798 patent is accompanied by serious side effects that cause unnecessary irritation to the skin, there are practically a lot of problems in using this directly in the treatment of acne.

Accordingly, an object of the present invention is to realize a complex composition that can cope and treat not only "inflammation / bacteria", but also each of the other causes identified as the main mechanism of acne development, through which the final acne Therapeutic products are intended to induce, for example, "skin inflammation removal function", "acne bacteria removal function", "skin abnormality keratinocyte suppression function", "sebum oversecretion suppression function" and the like.

Still other objects of the present invention will become more apparent from the following detailed description.

In order to achieve the above object, in the present invention, a predetermined active ingredient, for example, 0.01 to 20 parts by weight of Herbal Extract (Flavor) containing, 0.01 to 20 parts by weight of Glycyrrhiza extract, Disclosed is a composition for treating acne formed by mixing 0.01 to 20 parts by weight of Phellodendronamurense extract and 0.001 to 1 parts by weight of salicylic acid.

At this time, preferably, the above-described herbal extract, for example, Burdock extract (Burdock extract) is used.

In the composition for treating skin diseases of the present invention having such a configuration, first, the burdock extract performs a function of inhibiting any one of the "acne generating mechanism", for example, "a phenomenon in which the sebum is excessively secreted from the skin". In general, the excessive secretion of sebum occurs because a specific enzyme called 5-alpha-reductase acts on sebaceous gland of the skin and promotes sebum secretion. As is known, the verdok extract of the present invention inhibits the activity of 5-alpha-reductase by using the tinnic acid and the prever contained in itself, and thus, endows itself with "sebum oversecretion function. "Can be done smoothly.

In addition, the licorice extract of the present invention, which is mixed with the above-mentioned burdock extract, performs a function of removing any one of the "acne generating mechanism", for example, "skin inflammation". The reason that the previous Burdock extract can perform this "skin inflammation removal function" is because it contains a substance called "Glycylrrhizin acid" as a main ingredient. Usually, this glycylic acid is, for example, as disclosed in Korean Patent Publication No. 2000-49485, "Method of manufacturing high purity licorice purified water", Korean Patent Publication No. 2001-10664, "Jinyang patch composition and transdermal administration system". It is known that it has a series of excellent anti-inflammatory functions. In the present invention, a new application of licorice extract containing this glycylic acid as a main component is combined and mixed with the previous burdock extract in an acne treatment composition. In addition, the composition finally finished by the present invention will be induced to simultaneously retain the excellent "skin inflammation removal function" with the "sebum oversecretion inhibiting function".

On the other hand, the yellowish white extract of the present invention, which is mixed with the above-mentioned Burdock extract, licorice extract and the like performs another function of "acne generating mechanism", for example, "acne bacteria". Usually, the yellowish white extract is disclosed in, for example, Korean Patent Laid-Open Publication No. 1999-75521 "Cosmetic Containing Herbal Extracts with Wrinkle Improvement Effect", Korean Patent Laid-Open Publication No. 2001-10368 "Skin Control Cosmetic Composition for Skin", Korean Patent As disclosed in Japanese Patent Application Laid-Open No. 2001-18655, "Cosmetic Composition Containing Rhubarb Extract," and the like, it possesses excellent "skin adaptability" and US Patent Publication No. 5080900 "Dermatitis Containing Red Oak Sap Extract. As shown in "Treatment of skin ulcers with an aqueous extract of oak bark ash", it is known to possess excellent antibacterial function. In the present invention, the new application of the yellowish white extract, the aforementioned Burdock extract , With licorice extract, etc., are mixed and mixed into a composition for treating acne, and through this, for example, an eye that resides in a hair follicle of the skin By facilitating the removal of bacteria, the composition finalized by the present invention, together with the "sebum secretion inhibiting function", "skin inflammation removal function" and the like described above, to induce a good "acne bacteria removal function" at the same time do.

On the other hand, the salicylic acid of the present invention, which is mixed with the above-mentioned Burdock extract, licorice extract, yellowish white extract and the like performs another function of "acne generation mechanism", for example, "skin abnormality". Usually, this salicylic acid has a beta-hydroxy acid as a main component, for example, Korean Patent Publication No. 1998-43225 "Antifungal Cosmetic Soap Composition", Korean Patent Publication No. 2001-11241 As shown in the "protective cream composition for skin" and the like, it is known that it has excellent skin exfoliation function and wrinkle removal function. In the present invention, the salicylic acid is newly applied, and the aforementioned burdock extract, licorice extract, By combining and mixing with acne treatment composition, such as sulfur white extract, the composition finally finished by the present invention together with the "sebum secretion suppression function", "skin inflammation removal function", "acne bacteria removal function" and the like, It can be induced to simultaneously possess excellent "skin aberration suppression function".

In short, in the present invention, by mixing an appropriate amount of the above-mentioned Burdock extract, licorice extract, yellowish white extract, salicylic acid and the like, not only "inflammatory / bacterial", but also each of the other causes identified as the main mechanism of acne can be treated individually To realize a complex composition, through which the final acne treatment product is, for example, "skin inflammation removal", "acne bacteria removal", "skin abnormal keratin suppression", "sebum oversecretion suppression" It can be induced to hold the back at once.

Hereinafter, a method of preparing the aforementioned acne treatment composition will be described in detail.

In the present invention, first, the process of mixing 0.01 to 20 parts by weight of Burdock extract containing 0.01 to 20 parts by weight of purified water (Refined water), 0.01 to 20 parts by weight of licorice extract, and 0.01 to 20 parts by weight of white and white extract do.

At this time, if the content of the burdock extract is less than 0.01 parts by weight, it may cause a problem that the effect of the hub itself is not exhibited, if the content of the burdock extract exceeds 20 parts by weight, "the odor of the final product is too strong Problem "," the problem that only raw materials are wasted without additional effects "and the like, in view of the above problems in the present invention, the content of the Burdock extract in the aforementioned" 0.01 to 20 parts by weight " Maintain appropriately at.

In addition, if the content of licorice extract is less than 0.01 parts by weight, a problem that the intrinsic effect of licorice extract may not be exhibited, may cause a problem, if the content of licorice extract exceeds 20 parts by weight, "Fragrance of the final finished product is too Since the problem of becoming stronger "," a problem that only raw materials are wasted without any additional effects ", etc. can be caused, the present invention fully takes account of these problems, and the content of licorice extract is" 0.01 to 20 parts by weight ". Maintain appropriately within.

In addition, when the content of the yellow-white extract is less than 0.01 parts by weight, a problem in which the inherent effect of the white-white extract may not be exhibited, and when the content of the white-white extract exceeds 20 parts by weight, similar to the above case, " Since the problem of the fragrance of the finished product is too strong "," the problem that only raw materials are wasted without any additional effects ", etc. can be caused, in the present invention, in consideration of these problems, the content of sulfur white extract is mentioned above. It is appropriately maintained within one "0.01 to 20 parts by weight".

As described above, in the state in which the bourdog extract, licorice extract, sulfur white extract and the like are mixed in the purified water, in the present invention, in order to improve the mixing uniformity of the respective components, the previous purified water solution in a stirrer, for example, 600 rpm After 8 minutes to 12 minutes of stirring (Agitation) process, and after a certain period of time, when the above-described mixing and stirring process is completed, purified water solution mixed with the bergok extract, licorice extract, yellow white extract To form a first mixing intermediate.

On the other hand, independent of the above-mentioned process of forming the first mixed intermediate, in the present invention 1 to 50 parts by weight of alcohol, more preferably 5 to 30 parts by weight of salicylic acid 0.001 to 1 parts by weight, more preferably, 0.01 By advancing the process to mix 0.5 parts by weight, a series of second mixing intermediates are formed.

At this time, if the content of salicylic acid is less than 0.001 parts by weight, a problem that the intrinsic effect of salicylic acid may not be exhibited, and if the content of salicylic acid exceeds 1 part by weight, The problem to be added "can be caused, and in the present invention, in consideration of this problem, the content of salicylic acid is properly maintained within the aforementioned" 0.001 to 1 part by weight ".

In addition, when the content of alcohol is less than 1 part by weight, "the problem of not being able to dissolve salicylic acid properly", "problem of generating an unnecessary precipitate even if dissolved", etc. can be caused, the content of alcohol is 50 When exceeding parts by weight, since "problem of applying unnecessary irritation to skin" can be caused, the present invention takes full account of these problems, so that the content of alcohol is properly maintained within the aforementioned "1 to 50 parts by weight". Let's do it.

On the other hand, when the formation of the first mixed intermediate and the second mixed intermediate is completed through the above-described process, in the present invention, the first and second mixed intermediates described above are uniformly mixed with each other and the first and second mixed intermediates are formed. For example, the process of heating the mixed intermediate to a temperature of about 75 ~ 85 ℃.

When such a heating process is performed, the present invention, for example, moisturizing accelerators such as vegetable oil, Setostearyl alcohol, Glycerol Stearate, Polyoxyethylene, Stearate, etc. By further adding to the first and second mixed intermediates, the finally completed composition for acne treatment can maintain a series of moisturizing properties for a long time.

Subsequently, when all the above-described heating processes are completed, in the present invention, the first and second mixed intermediates heated in the mixed state are cooled to, for example, a temperature of about 35 ° C to 45 ° C, and the first and second mixings in which the cooling is completed are completed. Additional additives such as pigments, antiseptics, perfumes, and the like are further added and stirred to the intermediate to prepare and complete the final acne treatment composition.

Hereinafter, the effects of the present invention will be described in detail through specific examples and comparative examples.

First, in Example 1, as shown in Table 1 below, "10 parts by weight of purified water" "0.1 parts by weight of Burdock extract, 0.1 parts by weight of licorice extract, 0.1 parts by weight of white and white extract" mixture at 600rpm 10 The mixture is stirred for a minute to form a series of first mixed intermediates, and separately, 0.1 parts by weight of salicylic acid is mixed with 5 parts by weight of alcohol to form a series of second mixed intermediates.

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 edifice 0.1 parts by weight of Burdock extract 0.1 parts by weight of Burdock extract 1 part by weight of Burdock extract Licorice extract 0.1 parts by weight Licorice Extract 1 part by weight Licorice extract 1 part by weight Yellow White Extract 0.1 parts by weight Yellow White Extract 1 part by weight 1 part by weight of yellow white extract 0.1 parts by weight of salicylic acid Salicylic Acid 1 part by weight 1 part by weight of salicylic acid 10 parts by weight of purified water 10 parts by weight of purified water Equivalence Equivalence Equivalence 5 parts by weight of alcohol 5 parts by weight of alcohol Equal amount 10 parts by weight of vegetable oil 10 parts by weight of vegetable oil Equal amount Equivalence Equivalence Equivalence Cetostearyl alcohol 2 parts by weight Cetostearyl alcohol 2 parts by weight Equal amount Equivalence Equivalence Equivalence 2 parts by weight of glycerol stearate 2 parts by weight of glycerol stearate Equal amount Equivalence Equivalence Equivalence 100 parts by weight of polyoxyethylene 100 parts by weight of polyoxyethylene Equal amount Equivalence Equivalence Equivalence 1 part by weight of stearate 1 part by weight of stearate Equal amount Equivalence Equivalence Equivalence Spices Spices, pigments Equal amount Equivalence Equivalence Equivalence

Subsequently, while heating the formed first and second mixed intermediates uniformly to each other at 80 ° C., 10 parts by weight of vegetable oil, 2 parts by weight of cetostearyl alcohol and glycerol were added to the first and second mixed intermediates. 2 parts by weight of stearate, 100 parts by weight of polyoxyethylene, and 1 part by weight of stearate are further added.

Subsequently, when the above-described heating process is completed, in Example 1, the preheated first and second mixed intermediates are cooled to, for example, 40 ° C., and pigments, perfumes, and the like are applied to the first and second mixed intermediates where cooling is completed. By further adding and stirring, a final acne treatment composition is produced and completed.

Next, in Example 2, except that "the content of Burdock extract is 1 part by weight, the licorice extract is 1 part by weight, the content of sulfur white extract is 1 part by weight, and the content of salicylic acid is 1 part by weight," The rest of the process is carried out in the same manner as in Example 1 to prepare and complete the final acne treatment composition.

On the other hand, as shown in Table 1, in Comparative Example 1, without mixing licorice extract, yellowish white extract, salicylic acid, except for mixing only 1 part by weight of the Burdock extract, Example 1 Proceed in the same manner as described above to produce and complete the final acne treatment composition.

Next, in Comparative Example 2, except for mixing only 1 part by weight of only salicylic acid, without mixing the verdok extract, licorice extract, yellowish white extract, and the rest of the process in the same manner as in Example 1, the final acne treatment The composition for manufacture is manufactured and completed.

Next, in Comparative Example 3, except that 1 part by weight of only white and white extracts were mixed without mixing the verdock extract, licorice extract, and salicylic acid, the rest of the procedure was carried out in the same manner as in Example 1, and the final acne The therapeutic composition is prepared and completed.

Next, in Comparative Example 4, except that 1 part by weight of licorice extract was mixed without mixing the verdock extract, the yellowish white extract and salicylic acid, the rest of the procedure was carried out in the same manner as in Example 1, Prepare and complete the composition for acne treatment.

Hereinafter, the effects of the present invention will be described in detail based on the test results of the acne treatment composition prepared through the aforementioned "Example 1 and Example 2" and "Comparative Examples 1 to 4".

division Example 1 Example 2 Minimum inhibitory concentration 750 ppm 700 ppm

First, the Applicant disinfects the microorganism elimination and filtering the composition for acne treatment prepared through "Examples 1 and 2" to an appropriate experimental concentration, and then "activates" each acne treatment composition. 1% of acne test bacteria, and the acne treatment composition was anaerobicly cultured at a temperature of 37 ° C. for 48 hours, and then the minimum inhibitory concentration (MIC: Minimum Inhibitory) of each acne treatment composition for the acne test bacterium. By measuring the concentration, the "bacterial function" of the acne treatment composition according to the present invention was evaluated.

As a result, as shown in Table 2 above, the compositions for acne treatment of the present invention prepared in Examples 1 and 2 are at the minimum inhibitory concentration values of 600 ppm and 700 ppm, respectively, Results ", the applicant confirmed that the" composition for acne treatment according to the present invention "has an excellent" acne bacteria removal function ".

Next, the applicant proceeds a series of acne treatment effect observation process, and verified the acne relief effect of the acne treatment composition prepared through the present invention.

First, the applicant selected 20 women corresponding to the "age group of 15 to 20 years" as the experimental group, and then the women for the experimental group frequency of the acne treatment composition prepared by Example 2 twice a day Application for 4 weeks.

division Example 2 Comparative Example 1 Comparative Example 2 3 in comparison Comparative Example 4 Number of people who showed significant mitigation effect 8 3 One 0 0 The number of people with mitigation effect 12 7 6 2 3 The number of people who do not have mitigation effect 0 10 12 18 17

At this time, the Applicant is in Example 2 on one cheek of women corresponding to each experimental group in order to accurately compare the effect of the acne treatment composition prepared by the present invention and the effect of the acne treatment composition prepared by the Comparative Example It was made to apply the composition for acne treatment prepared by, and to the other ball was applied to the acne treatment composition prepared by "Comparative Example 1 to Comparative Example 4".

After 4 weeks, Applicant visually observed the acne relief effect of women in each experimental group, and completed a series of acne treatment effect verification process.

As a result of such a measurement process, the Applicant has provided a clear acne relief effect to all 20 women in the case of the acne treatment composition prepared through Example 2 of the present invention, as shown in Table 3 above. On the other hand, in the case of each acne treatment composition prepared through "Comparative Example 1 to Comparative Example 4", only a "10, 7, 2, 3" women provide a series of acne relief effect It was confirmed.

Of course, these results are not only "skin inflammation removal function", "acne bacteria removal function" described above, the acne treatment composition prepared through the present invention, "skin abnormality suppression function", "sebum oversecretion suppression function" It is a testament to the fact that it even holds it all at once.

In the above, as described in detail, in the present invention, by mixing an appropriate amount of the Burdock extract, licorice extract, yellowish white extract, salicylic acid, etc., not only "inflammatory / bacterial", but also each of the other causes identified as the main mechanism of acne development It implements a composite composition that can respond to and treat.

When the present invention is achieved, the final acne treatment product is, for example, "skin inflammation removal", "acne bacteria removal", as well as "skin abnormal keratin suppression", "sebum oversecretion suppression" Can be held at once.

The present invention is generally useful in various acne treatment products, such as "acne cream", "acne treatment essence", "acne pack", and the like without particular limitation to the dosage form. Effect.

And while certain embodiments of the invention have been described and illustrated, it will be apparent that the invention may be embodied in various modifications by those skilled in the art.

Such modified embodiments should not be understood individually from the technical spirit or point of view of the present invention and such modified embodiments should fall within the scope of the appended claims of the present invention.

Claims (3)

0.01 to 20 parts by weight of a herb extract (Herbal extract), a licorice extract (Glycyrrhiza extract), 0.01 to 20 parts by weight, Phellodendron amurense extract, 0.01 to 20 parts by weight and salicylic acid (Salicylic) acid) A composition for treating acne, characterized in that it is formed by mixing 0.001 to 1 parts by weight of each other. According to claim 1, wherein the herbal extract is a composition for treating acne, characterized in that the Burdock extract (Burdock extract). A series of first mixing intermediates are mixed by mixing 0.01 to 20 parts by weight of a herb extract, 0.1 to 20 parts by weight of licorice extract and 0.1 to 20 parts by weight of sulfur white extract, in a predetermined amount of purified water. ), And from 1 to 50 parts by weight of alcohol are mixed with 0.001 to 1 parts by weight of salicylic acid to form a series of second mixed intermediates, and the previously formed first and second mixed intermediates are uniformly mixed with each other. And heating to a constant temperature; And cooling the first and second mixed intermediates heated in a mixed state to a predetermined temperature.