KR20020047240A - 기관지확장제 튜로부테롤의 경피투여를 위한염산튜로부테롤을 함유하는 경피 치료 시스템 - Google Patents
기관지확장제 튜로부테롤의 경피투여를 위한염산튜로부테롤을 함유하는 경피 치료 시스템 Download PDFInfo
- Publication number
- KR20020047240A KR20020047240A KR1020027004866A KR20027004866A KR20020047240A KR 20020047240 A KR20020047240 A KR 20020047240A KR 1020027004866 A KR1020027004866 A KR 1020027004866A KR 20027004866 A KR20027004866 A KR 20027004866A KR 20020047240 A KR20020047240 A KR 20020047240A
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- KR
- South Korea
- Prior art keywords
- tulobuterol
- matrix
- transdermal therapeutic
- therapeutic system
- transdermal
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
실시예No. | 단위면적당 중량[g/m2]** | 저장층 구성성분 % | 피부방향층 % |
1 | 154.3 | 튜로부테롤-HCl 11.6유드라지트®E100 13.7듀로탁®2287*74.7올레산 ---- | 튜로부테롤-HCl ----유드라지트®E100 10.0듀로탁®2287*77.5올레산 12.5 |
2 | 166 | 튜로부테롤-HCl 16.3유드라지트®E100 19.3듀로탁®2287*64.4올레산 ---- | 튜로부테롤-HCl ----유드라지트®E100 10.0듀로탁®2287*72.7올레산 17.3 |
3 | 162.1 | 튜로부테롤-HCl 11.6유드라지트®E100 13.7듀로탁®2287*68.5올레산 6.2 | 튜로부테롤-HCl 11.6유드라지트®E100 15.1듀로탁®2287*67.1올레산 6.2 |
4 | 171.3 | 튜로부테롤-HCl 11.6유드라지트®E100 15.1듀로탁®2287*67.1올레산 6.2 | 튜로부테롤-HCl 11.6유드라지트®E100 15.1듀로탁®2287*67.1올레산 6.2 |
5 | 159.0 | 튜로부테롤-HCl 11.6유드라지트®E100 13.7듀로탁®2287*67.9올레산 6.2BHT 0.1Na2EDTA 0.5 | 튜로부테롤-HCl 11.6유드라지트®E100 15.1듀로탁®2287*67.1올레산 6.2BTH 0.1Na2EDTA 0.5 |
Claims (14)
- 제거가능한 보호층(protective layer)뿐만 아니라 수증기 불투과성 지지층(backing layer)및 활성물질 튜로부테롤를 포함하여 적어도 한가지의 활성물질을 함유한 매트릭스층(matrix layer)을 포함하는 것으로서, 상기 매트릭스는 폴리아크릴레이트 감압(pressure-sensitive)접착제를 기초로 하여 제조되고 염산튜로부테롤(tulobuterol hydrochloride)형태의 튜로부테롤을 활성물질로 가지는 것을 특징으로 하는 경피 치료 시스템.
- 제 1 항에 있어서, 상기 염산튜로부테롤의 질량 함유량은 상기 활성물질 함유 매트릭스 질량에 대하여 2.5 내지 20%이고, 바람직하게는 5 내지 10%인 것을 특징으로 하는 경피 치료 시스템.
- 제 1 항 또는 제 2 항에 있어서, 상기 활성물질함유 메트릭스는 측쇄(side chain)에 아미노 작용기를 가지는 폴리머를 함유하며, 상기 폴리머의 질량함유량은 활성물질 함유 메트릭스 질량에 대해 2 내지 20%, 바람직하게는 10 내지 16%인 것을 특징으로 하는 경피 치료 시스템.
- 제 3 항에 있어서, 상기 아미노 작용기를 포함하는 폴리머로서 부틸 메타크릴레이트-(2-디메틸-아미노에틸)-메틸 메타크릴레이트 코폴리머를 사용하는 것을특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 두번째 염산튜로부테롤 함유 메트릭스층을 더욱 포함하는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 폴리아크릴레이트 감압(pressure-sensitive) 접착제에 기초하고 제조직후 상태에서 활성물질을 함유하지 않는 적어도 하나의 부가 메트릭스층을 포함하는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 침투증진 부가제를 함유하는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 상기 매트릭스층에 하나 또는 그 이상의 지방산 바람직하게는 라우린산(lauric acid), 미리스틴산(myristic acid) 또는 올레산(oleic acid)을 함유하고, 상기 지방산(들)을 매트릭스 총질량에 대해 2 내지 20%, 바람직하게는 5 내지 10%의 농도로 함유하고 있는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 적어도 3일의 도포 기간 동안 0.5 내지 최대 6 mg 바람직하게는 2 내지 4 mg의 염산튜로부테롤이 통상 하루 복용량으로 경피투여될 수 있는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 적어도 하나의 메트릭스층이 하나 또는 그 이상의 부가적인 약제학적 활성물질을 더욱 함유하고 있는 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 상기 활성물질 함유 매트릭스의 단위 면적당 중량이 적어도 120g/m2인 것을 특징으로 하는 경피 치료 시스템.
- 상기 항 중 어느 한 항에 있어서, 항산화제(antioxidants)그룹, 바람직하게는 페놀계 합성물, 더욱 바람직하게는 부틸히드록시톨루엔 또는 부틸히드록시아니솔로부터 적어도 하나의 부가제를 함유하는 것을 특징으로 하는 경피 치료 시스템.
- 제 12 항에 있어서 금속이온착물제(metal ion complexing agent)그룹, 바람직하게는 시트르산(citric acid) 또는 에틸렌디아민테트라아세트산(EDTA), 더욱 바람직하게는 에틸렌디아민테트라아세트산이나트륨염(Na2EDTA)으로부터 적어도 하나의 부가제를 함유하는 것을 특징으로 하는 경피 치료 시스템.
- 천식 및 그와 관련된 질병 치료를 위한 제 1 항 내지 제 13 항 중 하나 또는그 이상의 항 기재의 경피 치료 시스템의 용도.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19950066A DE19950066A1 (de) | 1999-10-16 | 1999-10-16 | Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut |
DE19950066.5 | 1999-10-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20020047240A true KR20020047240A (ko) | 2002-06-21 |
KR101014074B1 KR101014074B1 (ko) | 2011-02-14 |
Family
ID=7925993
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027004866A KR101014074B1 (ko) | 1999-10-16 | 2002-04-16 | 기관지확장제 튜로부테롤의 경피투여를 위한 튜로부테롤 염산염을 함유하는 경피 치료 시스템 |
Country Status (12)
Country | Link |
---|---|
US (1) | US7056528B1 (ko) |
EP (1) | EP1220662B1 (ko) |
JP (2) | JP4874486B2 (ko) |
KR (1) | KR101014074B1 (ko) |
AR (1) | AR026040A1 (ko) |
AT (1) | ATE299019T1 (ko) |
AU (1) | AU7662400A (ko) |
CA (1) | CA2387143C (ko) |
DE (2) | DE19950066A1 (ko) |
ES (1) | ES2245648T3 (ko) |
PT (1) | PT1220662E (ko) |
WO (1) | WO2001028531A1 (ko) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100469995B1 (ko) * | 2002-05-20 | 2005-02-05 | 안국약품 주식회사 | 천식치료제를 함유한 매트릭스형 패취 |
KR101184810B1 (ko) * | 2003-06-20 | 2012-09-20 | 데이고꾸세이약꾸가부시끼가이샤 | 툴로부테롤 함유 패치 |
CN100457064C (zh) * | 2003-10-28 | 2009-02-04 | 诺芬药品公司 | 透皮递药装置 |
CN1297257C (zh) * | 2004-01-02 | 2007-01-31 | 上海现代药物制剂工程研究中心有限公司 | 含有妥洛特罗的压敏胶,透皮贴剂及制备方法和应用 |
JP4919807B2 (ja) * | 2004-11-10 | 2012-04-18 | 久光製薬株式会社 | 外用製剤及び貼付剤 |
WO2006051818A1 (ja) * | 2004-11-10 | 2006-05-18 | Hisamitsu Pharmaceutical Co., Inc. | 外用製剤及び貼付剤 |
US8080560B2 (en) * | 2004-12-17 | 2011-12-20 | 3M Innovative Properties Company | Immune response modifier formulations containing oleic acid and methods |
DE102004062614B4 (de) * | 2004-12-24 | 2011-12-29 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit aktivierbarer Übersättigung und kontrollierter Permeationförderung sowie Verfahren zu dessen Herstellung |
WO2010141587A1 (en) * | 2009-06-05 | 2010-12-09 | Megtec Systems, Inc. | Improved infrared float bar |
JP5766475B2 (ja) * | 2010-03-30 | 2015-08-19 | 日東電工株式会社 | 貼付製剤およびその製造方法 |
JP5906302B2 (ja) * | 2011-03-24 | 2016-04-20 | テイコク ファーマ ユーエスエー インコーポレーテッド | 作用剤層および作用剤変換層を含む経皮組成物 |
CA2842582C (en) * | 2011-07-21 | 2016-07-12 | Teikoku Seiyaku Co., Ltd. | Water-based plaster |
CN102552221B (zh) * | 2012-01-11 | 2013-09-04 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种妥洛特罗贴剂及其制备方法 |
NZ628481A (en) | 2012-01-11 | 2016-11-25 | Adelaide Res & Innovation Pty | Stabilising and analysing fatty acids in a biological sample stored on solid media |
KR101856515B1 (ko) | 2012-11-02 | 2018-05-10 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 프로피닐아미노인단 경피 조성물 |
EP3206673A1 (en) | 2014-10-17 | 2017-08-23 | Fidia Farmaceutici S.p.A. | Dermal therapeutic system with high adhesivity |
EP3395336A1 (en) * | 2017-04-28 | 2018-10-31 | Nitto Denko Corporation | Transdermal absorption preparation |
CN109541065B (zh) * | 2018-12-04 | 2019-10-01 | 山东大学 | 一种妥洛特罗贴剂的分析方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0667835B2 (ja) * | 1984-03-01 | 1994-08-31 | サンド・アクチエンゲゼルシヤフト | 医薬組成物 |
JPH0725669B2 (ja) | 1988-12-23 | 1995-03-22 | 日東電工株式会社 | 経皮投与用医薬製剤 |
DE4002281A1 (de) * | 1990-01-26 | 1991-08-01 | Lohmann Therapie Syst Lts | Transdermales therapeutisches system mit dem wirkstoff tulobuterol |
IT1251469B (it) | 1991-07-15 | 1995-05-15 | Zambon Spa | Sistema terapeutico transdermale per la somministrazione di farmaci ad attivita' broncodilatante. |
EP0593807A1 (en) * | 1992-10-22 | 1994-04-27 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation |
ES2180546T3 (es) * | 1992-07-23 | 2003-02-16 | Hisamitsu Pharmaceutical Co | Composicion basica administrable percutaneamente y composicion de farmaco preparada a partir de ella. |
JP2753800B2 (ja) * | 1994-04-14 | 1998-05-20 | 日東電工株式会社 | 経皮吸収型製剤 |
JP3466305B2 (ja) * | 1994-12-12 | 2003-11-10 | 久光製薬株式会社 | 溶解剤および該溶解剤を含有する外用製剤 |
AU4321297A (en) * | 1996-10-04 | 1998-04-24 | Saitama Daiichi Seiyaku Kabushiki Kaisha | Patch |
DE19653605C2 (de) * | 1996-12-20 | 2002-11-28 | Roehm Gmbh | Haft- und Bindemittel für dermale oder transdermale Therapiesysteme und dessen Verwendung zur Herstellung eines transdermalen Therapiesystems |
IT1294748B1 (it) * | 1997-09-17 | 1999-04-12 | Permatec Tech Ag | Formulazione per un dispositivo transdermico |
JP3930984B2 (ja) * | 1997-12-12 | 2007-06-13 | 日東電工株式会社 | 経皮吸収型製剤 |
US6375963B1 (en) * | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
-
1999
- 1999-10-16 DE DE19950066A patent/DE19950066A1/de not_active Ceased
-
2000
- 2000-10-06 AU AU76624/00A patent/AU7662400A/en not_active Abandoned
- 2000-10-06 CA CA002387143A patent/CA2387143C/en not_active Expired - Fee Related
- 2000-10-06 US US10/110,014 patent/US7056528B1/en not_active Expired - Fee Related
- 2000-10-06 DE DE50010679T patent/DE50010679D1/de not_active Expired - Lifetime
- 2000-10-06 WO PCT/EP2000/009788 patent/WO2001028531A1/de active IP Right Grant
- 2000-10-06 PT PT00966123T patent/PT1220662E/pt unknown
- 2000-10-06 ES ES00966123T patent/ES2245648T3/es not_active Expired - Lifetime
- 2000-10-06 JP JP2001531361A patent/JP4874486B2/ja not_active Expired - Fee Related
- 2000-10-06 EP EP00966123A patent/EP1220662B1/de not_active Expired - Lifetime
- 2000-10-06 AT AT00966123T patent/ATE299019T1/de active
- 2000-10-13 AR ARP000105398A patent/AR026040A1/es unknown
-
2002
- 2002-04-16 KR KR1020027004866A patent/KR101014074B1/ko not_active IP Right Cessation
-
2011
- 2011-08-05 JP JP2011171931A patent/JP2011252003A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE19950066A1 (de) | 2001-04-26 |
AR026040A1 (es) | 2002-12-26 |
CA2387143A1 (en) | 2001-04-26 |
ATE299019T1 (de) | 2005-07-15 |
ES2245648T3 (es) | 2006-01-16 |
US7056528B1 (en) | 2006-06-06 |
JP2003528037A (ja) | 2003-09-24 |
CA2387143C (en) | 2009-06-02 |
AU7662400A (en) | 2001-04-30 |
PT1220662E (pt) | 2005-10-31 |
JP2011252003A (ja) | 2011-12-15 |
EP1220662B1 (de) | 2005-07-06 |
EP1220662A1 (de) | 2002-07-10 |
WO2001028531A1 (de) | 2001-04-26 |
JP4874486B2 (ja) | 2012-02-15 |
DE50010679D1 (de) | 2005-08-11 |
KR101014074B1 (ko) | 2011-02-14 |
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