KR20020032469A - A pharmaceutical composition for wound healing - Google Patents

Abstract

PURPOSE: A pharmaceutical composition containing alum and triclosan as an effective component is provided which can prevent incidence of secondary infection by inhibiting itching as well as treating healing wound. CONSTITUTION: This pharmaceutical composition containing 0.01 to 1.0%(w/v) of alum, 0.01 to 1.0%(w/v) of triclosan and 5 to 15%(w/v) of 1,3-butyleneglycol and purified water is a formulation such as gel, paste, ointment frost, powder, oil or aerosol.

Description

Pharmaceutical composition for wound healing

The present invention relates to a pharmaceutical composition for treating wounds, and more particularly, to a novel composition for treating wounds containing alum and triclosan, which is effective in treating wounds and preventing secondary infection.

The skin that surrounds our bodies is exposed to various dangerous physical damages in our daily lives.

In addition to mechanical damage, bruises, and burns of the skin caused by mischievous pencil or nails at school, cat and dog claws caused by an increase in pets are one of the most common phenomena around us.

Recently, many laser treatments and dermabrasions (pilling) for cosmetic purposes such as spot removal, wrinkle removal, scar removal, etc. have been performed, and scars that occur after such skin treatment may cause scars in the healing process.

The most important thing in treating various kinds of skin damages is that scars should not occur after wound treatment. To do this, it is necessary to allow the new skin to rise quickly on the wound, preventing bacterial infection or other secondary damage from being added to the wound.

When the skin is damaged by wounds, burns, bedsores, ulcers, etc., the first thing that occurs is the basis of healing, the granulation tissue, which is the most important key in wound healing.

In addition, abnormal scars (thoracic), which may occur in the process of healing and scarring of damaged skin, depend on whether the collagen fiber, the main component of scar tissue, is biosynthesized and woven, or whether it is smooth or chaotic. can do.

They should be involved in the process of forming the new flesh to help produce the quality of the flesh quickly, and participate in the scar process to guide the process of biosynthesis and weaving of collagen fibers to the normal, so that scars should not occur.

In the meantime, various materials and materials for the treatment of wounds are constantly being developed and the demand thereof is increasing. In the technical field to which the present invention belongs, secondary infections are promoted by promoting the treatment of wounds and suppressing itching or rash with less erythema. There is a need for the development of a novel pharmaceutical composition that can be prevented.

The present inventors conducted a study to solve the above problems and found out that the pharmaceutical composition containing alum and triclosan as an active ingredient can prevent secondary infection as well as wound healing spout and completed the present invention.

Accordingly, it is an object of the present invention to provide a novel pharmaceutical composition that promotes the treatment of wounds and prevents secondary infections by suppressing itching or soreness while having less erythema.

1 is the erythema after 3 weeks after treating the wound using the pharmaceutical composition for wound treatment according to the present invention,

Figure 2 shows the state of the wound before treatment.

The present invention provides a pharmaceutical composition for treating wounds containing 0.01 to 1.0% (w / v) of alum and 0.01 to 1.0% (w / v) of triclosan as an active ingredient as a means for achieving the above object.

The pharmaceutical composition for treating wounds according to the present invention is a liquid formulation containing an effective amount of alum and triclosan and at the same time containing purified water, or a gel, paste, ointment frost, powder, containing a pharmaceutically acceptable excipient or carrier, It can be prepared in the form of an emulsion or aerosol.

Alum (alum; KAl (SO ₄ ) ₂ ㆍ 12H ₂ O) is made by refining a mineral named alum. The collected and dried alum is a complex of potassium and aluminum sulphate, which contains a small amount of iron and calcium.

Alum has been used as a drug for aggression and tumors since ancient times because it causes protein precipitation as a converging agent and thereby acts as an antibacterial (exudative) inhibitor.

Triclosan not only has a wide and rapid bactericidal effect on Gram-positive and most Gram-negative bacteria, but has little effect by organic matter and has a continuous bactericidal effect on non-existent bacteria.

Triclosan has been used as a fungicide since the 1960s, and bacteria are known to inhibit the enzyme FabI, which is required for the production of fatty acids using cell membranes.

However, because animals use very different enzymes, triclosan is harmless to humans, so it is widely used as a raw material for cosmetics as well as toothpaste, skin ointment and oral composition for treating periodontitis.

The pharmaceutical composition for treating wounds according to the present invention comprises alum as an active ingredient 0.01 to 1.0% (w / v) and triclosan 0.01 to 1.0% (w / v), preferably alum 0.1-0.5% (w / v) Triclosan 0.05 to 0.3% (w / v) and 1,3-butylene glycol (1,3-butylene glycol) 5 to 15% (v / v), purified water and trace excipients.

Containing more than 1.0% (w / v) of alum may cause side effects such as irritation, redness, itching, and pain, and 1.0% (w / v) of triclosan. If it contains more than that, skin irritation may occur.

The pharmaceutical composition for treating wounds in the liquid form according to the present invention is prepared by dissolving triclosan completely in 1,3-butylene glycol to prepare triclosan solution, completely dissolving alum in purified water, and preparing alum solution, respectively. The solution is placed in a container, and then prepared by adding alum solution.

At this time, when trichloroic acid is added to a 1,3-butylene glycol solution in which 1,3-butylene glycol is dissolved in purified water without dissolving trichloroic acid in 1,3-butylene glycol, trichloroic acid does not dissolve well and precipitates are formed. When the alum is added to the triclosan solution prepared above, the alum is not dissolved in purified water, but if it is added directly, the alum does not dissolve and remains in the form of granules. It is preferable to use alum after completely dissolving it in purified water.

The pharmaceutical composition according to the present invention may further include other conventional agents having wound healing functions such as anti-inflammatory agents, antimicrobials, analgesics, alleviators or astringents, apart from the above-mentioned effective ingredients. Those skilled in the art will be readily able to practice the invention.

Excipients or carriers included in the pharmaceutical composition for treating wounds according to the present invention include those commonly used in gels, pastes, ointments, frosts, powders, emulsions or aerosol formulations. Can be used.

In addition, the pharmaceutical composition for wound treatment according to the present invention can be used in addition to cosmetics, lotions for washing or sunscreen.

Hereinafter, the present invention will be described in detail through examples and test examples. However, these Examples and Test Examples are intended to describe the present invention in more detail, and are not intended to limit the scope of the present invention to this.

Example 1 (Preparation of Liquid)

0.1 g of triclosan was completely dissolved in 10 ml of butylene glycol to prepare a triclosan solution, and 0.3 g of alum was completely dissolved in 90 ml of purified water to prepare alum solution.

The triclosan solution prepared above was first put in a container, and then alum solution was added and mixed well to prepare a wound-healing composition in a liquid form.

Example 2 (Preparation of Liquid Formulation)

0.5 g of triclosan was completely dissolved in 10 ml of butylene glycol to prepare a triclosan solution, and 0.8 g of alum was completely dissolved in 90 ml of purified water to prepare alum solution.

The triclosan solution prepared above was first put in a container, and then alum solution was added and mixed well to prepare a wound-healing composition in a liquid form.

Example 3 (Preparation of Liquid Formulation)

1.0 g of triclosan was completely dissolved in 10 ml of butylene glycol to prepare a triclosan solution, and 1.0 g of alum was completely dissolved in 90 ml of purified water to prepare alum solution.

The triclosan solution prepared above was first put in a container, and then alum solution was added and mixed well to prepare a wound-healing composition in a liquid form.

Example 4 (Preparation of Paste Preparation)

0.1 g of triclosan, 0.3 g of alum and 99.6 g of petrolatum were mixed and a pharmaceutical composition for wound treatment in paste form was prepared by a conventional formulation method.

Example 5 Preparation of Ointment

0.1 g of triclosan, 0.3 g of alum and 99.6 g of an ointment base were mixed and a pharmaceutical composition for wound treatment in the form of an ointment was prepared by a conventional formulation method.

<Test Example 1> (Application method fidelity)

In order to investigate the effect of the pharmaceutical composition for wound healing according to the present invention on the wound treatment, a woman of 20-59 years of age who was treated with alexandrite or carbon dioxide laser as a person with bilateral pigmentation or tuberculosis on the face Table 1 shows the results of investigating the fidelity of the method of applying the liquid formulation prepared in Example 1 to seven subjects.

The test procedure for the investigator was cold treatment for 3 minutes, once a day for 20 minutes with liquid solution prepared in Example 1 on the right side of the eye, based on the midline for 3 weeks from the day of laser treatment. Bactroban ™ ointment (Hanol Pharm; Mupirocin 0.2g, 9.8g ointment base) sold on the left side of the face is prohibited for the first 3 days after treatment and for 4 days after treatment. Apply three times a day for three weeks.

At this time, put a layer of gauze of the appropriate size on the skin, and then poured into the gauze so as not to flow the liquid prepared in Example 1 to keep it moist and drop a few drops every 5 minutes to maintain a moist state, ointment Wipe clean before applying and apply very thin as if it is not.

The reason for the cold compress is that the cold compress evaporates water to soothe the wound and cool and dry the wound, resulting in vasoconstriction, thereby reducing erythema and burning sensation associated with irritation.

<Table 1> Application method fidelity

Coating fidelity Example 1 Control use 6 (85.7%) 6 (85.75) Filtered for use with side effects 1 (14.3%) 1 (14.3%) Interrupted by side effects 0 (0%) 0 (0%) I can't stop 0 (0%) 0 (0%) Sometimes lost 0 (0%) 0 (0%)

As shown in Table 1, the same result was observed in the fidelity of the coating method between the liquid formulation prepared in Example 1 and the control.

Test Example 2 (Skin Change)

The test was carried out in the same manner as in Example 1, but the results of the investigation of the skin change before and after the test subjects are shown in Table 2.

<Table 2> Changes in Skin

Skin changes Example 1 Control none 2 (28.6%) 2 (28.6%) Wrinkles are reduced 0 (0%) 0 (0%) Face becomes manic 3 (42.9%) 4 (57.1%) Face tingling 2 (28.6%) 1 (14.3%)

As shown in Table 2, the skin change between the liquid formulation prepared in Example 1 and the control did not cause any difference.

<Test Example 3> (Arousal Symptoms)

Subjected as in Test Example 1, subjective symptoms such as erythema, itching, etc. that occur after laser treatment, including all the symptoms felt when using the ointment used as a liquid formulation and a control prepared in Example 1 subjective symptoms of the wound site The results of the investigation are shown in Table 3.

<Table 3> Subjective Symptoms of Wounds

Subjective symptoms Example 1 Control none 3 (57.1%) 2 (28.6%) Erythema 1 (14.3%) 0 (0%) exfoliation 0 (0%) 2 (28.6%) Itching 2 (28.6%) 5 (71.4%) Fever 1 (14.3%) 2 (28.6%) pain 0 (0%) 2 (28.6%) Rash 0 (0%) 0 (0%) Singing 0 (0%) 0 (0%) Outbreak 0 (0%) 1 (14.3%)

As shown in Table 3, the itching of the site using the ointment as a control was significantly increased to 71.4% compared to the site using the liquid formulation prepared in Example 1.

This may be accompanied by erythema, hot flashes, and itching, especially when receiving laser treatment, which may be a result of inflammatory reactions caused by skin damage or various cytokine secretions that occur during wound healing.

<Test Example 4> (Title drop time)

The test was carried out as in Example 1, but after applying the ointment used in the liquid formulation and the control prepared in Example 1 and the dropping time of the scab formed on the wound site was shown in Table 4.

<Table 4> Dropping date

Scab Example 1 Control 10% dropout 6 days 5.2 days 50% dropout 9th 9th 90% dropout 11th 10 days

As shown in Table 4, the time of scab drop was not different between the two materials. In other words, at 90% of the time of scab removal, the two substances could not be found to be 11 days in liquid formulation and 10 days in ointment, but the scab of the wound area using ointment was thick and deep.

In addition, when using ointment, the scab is pushed when applied and falls off before the wound is sufficiently healed.However, when using liquid preparations, the scab is not completely applied after the wound healing process because no physical force is applied to the wound. The dropout could be observed.

Because the scab also prevents water evaporation and prevents bacterial infection from the outside, the scab must heal until the dermis and epidermis are completely regenerated so that the wound can heal with a good appearance. While it should be applied carefully so as not to be removed, there is no such burden when using a liquid formulation has the advantage that the general public can easily use at home.

<Test Example 5> (occurrence of erythema after scab drop)

In the same manner as in Test Example 1, in order to objectively evaluate the effect on the wound treatment of the pharmaceutical composition for wound treatment according to the present invention, the results of erythema incidence after scab removal were measured using a chromameter. 5 is shown.

<Table 5> Erythema Generation

(Unit: L * a * b)

Erythema development Example 1 Control Survey 1 11.42 12.38 Survey 2 10.86 12.63 Survey 3 11.01 11.78 Survey 4 15.19 17.32 Survey 5 15.14 17.70 Survey 6 18.07 17.31 Survey 7 10.28 9.89

In five of the seven patients, the erythema was reduced on the side of the ointment using the ointment. As shown in Table 5, not only the difference was observed in terms of the size using the chromameter, but also shown in FIGS. 1 and 2. Likewise, a clear difference could be observed even with the naked eye.

The pharmaceutical composition for wound treatment according to the present invention can be effectively used as a wound treatment because it is effective in wound healing and prevention of secondary infection by inhibiting the occurrence of erythema and itching or soreness of the wound.

Claims (4)

Pharmaceutical composition for wound treatment containing alum 0.01 to 1.0% (w / v) and triclosan 0.01 to 1.0% (w / v) as an active ingredient. The method of claim 1, The pharmaceutical composition comprises alum 0.01-1.0% (w / v) and triclosan 0.01-1.0% (w / v), 1,3-butylene glycol 5-15% (v / v) and purified water Pharmaceutical composition for wound treatment. The method of claim 1, Pharmaceutical composition for wound treatment, characterized in that the pharmaceutical composition comprises a pharmaceutically acceptable excipient or carrier. The method according to claim 1 or 3, The pharmaceutical composition for wound treatment, wherein the pharmaceutical composition is a gel, paste, ointment frost, powder, emulsion or aerosol.