KR20010100588A - 엑시머레이저 각막절제술 후 항염증, 항섬유화, 조직유착및 반흔형성억제 작용을 가지는 양막의 약학적 조성물 - Google Patents
엑시머레이저 각막절제술 후 항염증, 항섬유화, 조직유착및 반흔형성억제 작용을 가지는 양막의 약학적 조성물 Download PDFInfo
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- KR20010100588A KR20010100588A KR1020000023862A KR20000023862A KR20010100588A KR 20010100588 A KR20010100588 A KR 20010100588A KR 1020000023862 A KR1020000023862 A KR 1020000023862A KR 20000023862 A KR20000023862 A KR 20000023862A KR 20010100588 A KR20010100588 A KR 20010100588A
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- inflammatory
- corneal
- amniotic membrane
- pharmaceutical composition
- excimer laser
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Ophthalmology & Optometry (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Rabbits | OD(AM oint group) | sum | 평균 | p | ||||
1 | 1 | 1 | 1 | 1 | 1 | 5 | 1.00 | |
2 | 6 | 6 | 9 | 1 | 1 | 23 | 4.60 | |
3 | 3 | 2 | 2 | 1 | 2 | 10 | 2.00 | |
4 | 1 | 1 | 1 | 2 | 1 | 6 | 1.20 | |
5 | 3 | 1 | 1 | 2 | 1 | 8 | 2.00 | |
6 | 3 | 5 | 1 | 2 | 4 | 15 | 3.00 | |
7 | 2 | 2 | 1 | 3 | 1 | 9 | 1.80 | |
8 | 1 | 2 | 3 | 2 | 1 | 9 | 1.80 | |
9 | 3 | 4 | 3 | 2 | 2 | 14 | 2.80 | |
10 | 8 | 2 | 2 | 2 | 2 | 16 | 3.20 | |
2.34 | 0.000116 |
OS(Control) | 평균 | ||||||
1 | 4 | 8 | 9 | 10 | 12 | 43 | 8.60 |
2 | 22 | 11 | 23 | 23 | 28 | 107 | 21.40 |
3 | 10 | 12 | 8 | 7 | 5 | 42 | 8.40 |
4 | 2 | 1 | 8 | 7 | 4 | 22 | 4.40 |
5 | 12 | 9 | 7 | 13 | 7 | 48 | 9.60 |
6 | 3 | 9 | 17 | 16 | 3 | 48 | 9.60 |
7 | 18 | 17 | 6 | 7 | 13 | 61 | 12.20 |
8 | 12 | 3 | 5 | 7 | 15 | 42 | 8.40 |
9 | 18 | 16 | 12 | 5 | 17 | 68 | 13.60 |
10 | 13 | 5 | 4 | 7 | 6 | 35 | 7.00 |
10.32 |
변수 1 | 변수 2 | |
평균 | 11.5 | 51.6 |
분산 | 30.0556 | 540.2667 |
관측수 | 10 | 10 |
피어슨 상관 계수 | 0.72982 | |
가설 평균차 | 0 | |
자유도 | 9 | |
t 통계량 | -6.4684 | |
P(T<=t) 단측 검정 | 5.8E-05 | |
t 기각치 단측 검정 | 1.83311 | |
P(T<=t) 양측 검정 | 0.00012 | |
t 기각치 양측 검정 | 2.26216 |
Rabbits | OD(AM oint group) | sum | 평균 | p | ||||
1 | 32 | 53 | 78 | 44 | 27 | 234 | 46.8 | |
2 | 15 | 17 | 21 | 28 | 27 | 108 | 21.6 | |
3 | 14 | 27 | 30 | 19 | 25 | 115 | 23 | |
4 | 45 | 48 | 62 | 34 | 85 | 274 | 54.8 | |
5 | 17 | 16 | 16 | 14 | 29 | 92 | 18.4 | |
6 | 24 | 27 | 33 | 24 | 27 | 135 | 27 | |
7 | 42 | 94 | 60 | 78 | 77 | 351 | 70.2 | |
8 | 8 | 7 | 9 | 8 | 5 | 37 | 7.4 | |
9 | 14 | 15 | 15 | 17 | 12 | 73 | 14.6 | |
10 | 54 | 48 | 66 | 78 | 40 | 286 | 57.2 | |
34.1 | 0.003578949 |
OS(Control) | 평균 | ||||||
1 | 58 | 77 | 88 | 97 | 100 | 420 | 84 |
2 | 87 | 44 | 58 | 98 | 87 | 374 | 74.8 |
3 | 27 | 29 | 44 | 22 | 21 | 143 | 28.6 |
4 | 77 | 95 | 85 | 121 | 88 | 466 | 93.2 |
5 | 18 | 21 | 27 | 45 | 13 | 124 | 24.8 |
6 | 52 | 23 | 30 | 31 | 37 | 173 | 34.6 |
7 | 122 | 115 | 38 | 44 | 52 | 371 | 74.2 |
8 | 42 | 17 | 13 | 22 | 27 | 121 | 24.2 |
9 | 38 | 42 | 41 | 35 | 27 | 183 | 36.6 |
10 | 37 | 55 | 61 | 87 | 131 | 371 | 74.2 |
54.92 |
변수 1 | 변수 2 | |
평균 | 170.5 | 274.6 |
분산 | 11378.05556 | 18727.4 |
관측수 | 10 | 10 |
피어슨 상관 계수 | 0.788075766 | |
가설 평균차 | 0 | |
자유도 | 9 | |
t 통계량 | -3.907387395 | |
P(T<=t) 단측 검정 | 0.001789475 | |
t 기각치 단측 검정 | 1.833113856 | |
P(T<=t) 양측 검정 | 0.003578949 | |
t 기각치 양측 검정 | 2.262158887 |
Claims (2)
- 유효한 성분을 함유한 양막의 채취방법 및 보관방법.
- 양막을 유효성분으로 함유하는 함염증 및 함섬유화 작용을 나타내는 안연고의 제조방법 및 조성물.
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KR10-2000-0023862A KR100377921B1 (ko) | 2000-05-04 | 2000-05-04 | 엑시머레이저 각막절제술에서의 안연고 제조방법 |
Applications Claiming Priority (1)
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KR10-2000-0023862A KR100377921B1 (ko) | 2000-05-04 | 2000-05-04 | 엑시머레이저 각막절제술에서의 안연고 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20010100588A true KR20010100588A (ko) | 2001-11-14 |
KR100377921B1 KR100377921B1 (ko) | 2003-03-29 |
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KR10-2000-0023862A KR100377921B1 (ko) | 2000-05-04 | 2000-05-04 | 엑시머레이저 각막절제술에서의 안연고 제조방법 |
Country Status (1)
Country | Link |
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KR (1) | KR100377921B1 (ko) |
Cited By (15)
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WO2004026244A2 (en) * | 2002-09-18 | 2004-04-01 | Emiliano Ghinelli | Use of a human amniotic membrane composition for prophylaxis and treatment of diseases and conditions of the eye and skin |
US20130344162A1 (en) * | 2011-02-14 | 2013-12-26 | Brenda S. Morse | Micronized placental tissue compositions and methods of making and using the same |
US8904664B2 (en) | 2012-08-15 | 2014-12-09 | Mimedx Group, Inc. | Dehydration device and methods for drying biological materials |
US9180145B2 (en) | 2012-10-12 | 2015-11-10 | Mimedx Group, Inc. | Compositions and methods for recruiting and localizing stem cells |
US9446142B2 (en) | 2013-05-28 | 2016-09-20 | Mimedx Group, Inc. | Polymer chelator conjugates |
US9603967B2 (en) | 2015-05-08 | 2017-03-28 | Vivex Biomedical, Inc. | Placental tissue assembly |
US9662355B2 (en) | 2013-01-18 | 2017-05-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
US9943551B2 (en) | 2012-08-15 | 2018-04-17 | Mimedx Group, Inc. | Tissue grafts composed of micronized placental tissue and methods of making and using the same |
US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
US10159744B2 (en) | 2012-11-19 | 2018-12-25 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US10441664B2 (en) | 2012-11-19 | 2019-10-15 | Mimedx Group, Inc. | Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent |
US10617785B2 (en) | 2014-08-28 | 2020-04-14 | Mimedx Group, Inc. | Collagen reinforced tissue grafts |
US10842824B2 (en) | 2014-01-17 | 2020-11-24 | Mimedx Group, Inc. | Method for inducing angiogenesis |
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Family Cites Families (2)
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KR960000849B1 (ko) * | 1992-08-07 | 1996-01-13 | 이보영 | 흑색 비닐 레쟈를 표지로 한 장부의 제조방법 |
KR20010098716A (ko) * | 2000-04-19 | 2001-11-08 | 김재찬 | 안구표면질환 치료용 양막 추출물 |
-
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- 2000-05-04 KR KR10-2000-0023862A patent/KR100377921B1/ko active Pre-grant Review Request
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US7871646B2 (en) | 2002-09-18 | 2011-01-18 | Repsco Llp | Use of a human amniotic membrane composition for prophylaxis and treatment of diseases and conditions of the eye and skin |
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US20130344162A1 (en) * | 2011-02-14 | 2013-12-26 | Brenda S. Morse | Micronized placental tissue compositions and methods of making and using the same |
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US10441664B2 (en) | 2012-11-19 | 2019-10-15 | Mimedx Group, Inc. | Cross-linked collagen with at least one bound antimicrobial agent for in vivo release of the agent |
US10159744B2 (en) | 2012-11-19 | 2018-12-25 | Mimedx Group, Inc. | Cross-linked collagen comprising metallic anticancer agents |
US11000553B2 (en) | 2013-01-18 | 2021-05-11 | Mimedx Group, Inc. | Placental tissue composition for for treating cardiac tissue damage |
US9662355B2 (en) | 2013-01-18 | 2017-05-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
US10206977B1 (en) | 2013-01-18 | 2019-02-19 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US11497791B1 (en) | 2013-01-18 | 2022-11-15 | Mimedx Group, Inc. | Isolated placental stem cell recruiting factors |
US11648281B2 (en) | 2013-01-18 | 2023-05-16 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
US10111910B2 (en) | 2013-01-18 | 2018-10-30 | Mimedx Group, Inc. | Methods for treating cardiac conditions |
US10029030B2 (en) | 2013-03-15 | 2018-07-24 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
US11389565B2 (en) | 2013-03-15 | 2022-07-19 | Mimedx Group, Inc. | Molded placental tissue compositions and methods of making and using the same |
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US10842824B2 (en) | 2014-01-17 | 2020-11-24 | Mimedx Group, Inc. | Method for inducing angiogenesis |
US10617785B2 (en) | 2014-08-28 | 2020-04-14 | Mimedx Group, Inc. | Collagen reinforced tissue grafts |
US9603967B2 (en) | 2015-05-08 | 2017-03-28 | Vivex Biomedical, Inc. | Placental tissue assembly |
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