KR20010043111A - Enzymatic nucleic acid treatment of diseases or conditions related to hepatitis c virus infection - Google Patents

Enzymatic nucleic acid treatment of diseases or conditions related to hepatitis c virus infection Download PDF

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Publication number
KR20010043111A
KR20010043111A KR1020007011999A KR20007011999A KR20010043111A KR 20010043111 A KR20010043111 A KR 20010043111A KR 1020007011999 A KR1020007011999 A KR 1020007011999A KR 20007011999 A KR20007011999 A KR 20007011999A KR 20010043111 A KR20010043111 A KR 20010043111A
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South Korea
Prior art keywords
rna
ribozyme
region
artificial sequence
stem
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KR1020007011999A
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Korean (ko)
Inventor
로오렌스 블라트
제임스 에이. 맥스위겐
엘리자베스 로버트
파멜라 에이. 파브코
데니스 매이스잭
Original Assignee
랄프 이. 크리스토퍼슨
리보자임 파마슈티칼스 인코포레이티드
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Priority claimed from US09/274,553 external-priority patent/US20020082225A1/en
Application filed by 랄프 이. 크리스토퍼슨, 리보자임 파마슈티칼스 인코포레이티드 filed Critical 랄프 이. 크리스토퍼슨
Publication of KR20010043111A publication Critical patent/KR20010043111A/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/332—Abasic residue

Abstract

C형 간염의 발현 및/또는 복제를 조절하는 효소적 핵산 분자.Enzymatic nucleic acid molecules that regulate the expression and / or replication of hepatitis C.

Description

Ｃ형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산 치료제 {ENZYMATIC NUCLEIC ACID TREATMENT OF DISEASES OR CONDITIONS RELATED TO HEPATITIS C VIRUS INFECTION}ENZYMATIC NUCLEIC ACID TREATMENT OF DISEASES OR CONDITIONS RELATED TO HEPATITIS C VIRUS INFECTION}

SEQUENCE LISTINGSEQUENCE LISTING

＜110＞ RIBOZYME PHARMACEUTICALS, INC.<110> RIBOZYME PHARMACEUTICALS, INC.

2950 Wilderness Place2950 Wilderness Place

Boulder, Colorado 80301Boulder, Colorado 80301

USAUSA

＜120＞ ENZYMATIC NUCLEIC ACID TREATMENT OF<120> ENZYMATIC NUCLEIC ACID TREATMENT OF

DISEASES OR CONDITIONS RELATED TO HEPATITIS CDISEASES OR CONDITIONS RELATED TO HEPATITIS C

VIRUS INFECTIONVIRUS INFECTION

＜130＞ 241/078-PCT<130> 241 / 078-PCT

＜140＞ PCT/US99/09027<140> PCT / US99 / 09027

＜141＞ 1999-04-26<141> 1999-04-26

＜150＞ 09/274,553<150> 09 / 274,553

＜151＞ 1999-03-23<151> 1999-03-23

＜150＞ 09/257,608<150> 09 / 257,608

＜151＞ 1999-02-25<151> 1999-02-25

＜150＞ 60/100,842<150> 60 / 100,842

＜151＞ 1998-09-18<151> 1998-09-18

＜150＞ 60/083,217<150> 60 / 083,217

＜151＞ 1998-04-27<151> 1998-04-27

＜160＞ 3118<160> 3118

＜170＞ FastSEQ for Windows Version 3.0<170> FastSEQ for Windows Version 3.0

＜210＞ 1<210> 1

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1<400> 1

cuacugucuu cacgc 15cuacugucuu cacgc 15

＜210＞ 2<210> 2

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2<400> 2

aaagcgucua gccau 15aaagcgucua gccau 15

＜210＞ 3<210> 3

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3<400> 3

agcgucuagc caugg 15agcgucuagc caugg 15

＜210＞ 4<210> 4

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 4<400> 4

ugagugucgu gcagc 15ugagugucgu gcagc 15

＜210＞ 5<210> 5

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 5<400> 5

gagccauagu ggucu 15gagccauagu ggucu 15

＜210＞ 6<210> 6

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 6<400> 6

uaguggucug cggaa 15uaguggucug cggaa 15

＜210＞ 7<210> 7

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 7<400> 7

ggugaguaca ccgga 15ggugaguaca ccgga 15

＜210＞ 8<210> 8

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 8<400> 8

accggguccu uucuu 15accggguccu uucuu 15

＜210＞ 9<210> 9

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 9<400> 9

ggguccuuuc uugga 15ggguccuuuc uugga 15

＜210＞ 10<210> 10

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 10<400> 10

gguccuuucu uggau 15gguccuuucu uggau 15

＜210＞ 11<210> 11

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 11<400> 11

guugggucgc gaaag 15guugggucgc gaaag 15

＜210＞ 12<210> 12

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 12<400> 12

aaggccuugu gguac 15aaggccuugu gguac 15

＜210＞ 13<210> 13

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 13<400> 13

gggugcuugc gagug 15gggugcuugc gagug 15

＜210＞ 14<210> 14

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 14<400> 14

gggaggucuc guaga 15gggaggucuc guaga 15

＜210＞ 15<210> 15

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 15<400> 15

gaggucucgu agacc 15gaggucucgu agacc 15

＜210＞ 16<210> 16

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 16<400> 16

gucucguaga ccgug 15gucucguaga ccgug 15

＜210＞ 17<210> 17

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 17<400> 17

uaaaccucaa agaaa 15uaaaccucaa agaaa 15

＜210＞ 18<210> 18

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 18<400> 18

caaacguaac accaa 15caaacguaac accaa 15

＜210＞ 19<210> 19

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 19<400> 19

caaccgucgc ccaca 15caaccgucgc ccaca 15

＜210＞ 20<210> 20

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 20<400> 20

gagcggucac aaccu 15gagcggucac aaccu 15

＜210＞ 21<210> 21

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 21<400> 21

guaaggucau cgaua 15guaaggucau cgaua 15

＜210＞ 22<210> 22

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 22<400> 22

uuuuuuuuuu uuuuu 15uuuuuuuuuu uuuuu 15

＜210＞ 23<210> 23

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 23<400> 23

gguggcucca ucuua 15gguggcucca ucuua 15

＜210＞ 24<210> 24

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 24<400> 24

gcuccaucuu agccc 15gcuccaucuu agccc 15

＜210＞ 25<210> 25

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 25<400> 25

uccaucuuag cccua 15uccaucuuag cccua 15

＜210＞ 26<210> 26

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 26<400> 26

ccaucuuagc ccuag 15ccaucuuagc ccuag 15

＜210＞ 27<210> 27

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 27<400> 27

uagcccuagu cacgg 15uagcccuagu cacgg 15

＜210＞ 28<210> 28

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 28<400> 28

cccuagucac ggcua 15cccuagucac ggcua 15

＜210＞ 29<210> 29

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 29<400> 29

cacggcuagc uguga 15cacggcuagc uguga 15

＜210＞ 30<210> 30

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 30<400> 30

gaaagguccg ugagc 15gaaagguccg ugagc 15

＜210＞ 31<210> 31

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 31<400> 31

gcgugaacug augaggccgu uaggccgaaa caguag 36gcgugaacug augaggccgu uaggccgaaa caguag 36

＜210＞ 32<210> 32

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 32<400> 32

auggcuacug augaggccgu uaggccgaaa cgcuuu 36auggcuacug augaggccgu uaggccgaaa cgcuuu 36

＜210＞ 33<210> 33

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 33<400> 33

ccauggccug augaggccgu uaggccgaaa gacgcu 36ccauggccug augaggccgu uaggccgaaa gacgcu 36

＜210＞ 34<210> 34

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 34<400> 34

gcugcaccug augaggccgu uaggccgaaa cacuca 36gcugcaccug augaggccgu uaggccgaaa cacuca 36

＜210＞ 35<210> 35

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 35<400> 35

agaccaccug augaggccgu uaggccgaaa uggcuc 36agaccaccug augaggccgu uaggccgaaa uggcuc 36

＜210＞ 36<210> 36

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 36<400> 36

uuccgcacug augaggccgu uaggccgaaa ccacua 36uuccgcacug augaggccgu uaggccgaaa ccacua 36

＜210＞ 37<210> 37

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 37<400> 37

uccggugcug augaggccgu uaggccgaaa cucacc 36uccggugcug augaggccgu uaggccgaaa cucacc 36

＜210＞ 38<210> 38

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 38<400> 38

aagaaagcug augaggccgu uaggccgaaa cccggu 36aagaaagcug augaggccgu uaggccgaaa cccggu 36

＜210＞ 39<210> 39

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 39<400> 39

uccaagacug augaggccgu uaggccgaaa ggaccc 36uccaagacug augaggccgu uaggccgaaa ggaccc 36

＜210＞ 40<210> 40

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 40<400> 40

auccaagcug augaggccgu uaggccgaaa aggacc 36auccaagcug augaggccgu uaggccgaaa aggacc 36

＜210＞ 41<210> 41

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 41<400> 41

cuuucgccug augaggccgu uaggccgaaa cccaac 36cuuucgccug augaggccgu uaggccgaaa cccaac 36

＜210＞ 42<210> 42

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 42<400> 42

guaccaccug augaggccgu uaggccgaaa ggccuu 36guaccaccug augaggccgu uaggccgaaa ggccuu 36

＜210＞ 43<210> 43

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 43<400> 43

cacucgccug augaggccgu uaggccgaaa gcaccc 36cacucgccug augaggccgu uaggccgaaa gcaccc 36

＜210＞ 44<210> 44

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 44<400> 44

ucuacgacug augaggccgu uaggccgaaa ccuccc 36ucuacgacug augaggccgu uaggccgaaa ccuccc 36

＜210＞ 45<210> 45

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 45<400> 45

ggucuaccug augaggccgu uaggccgaaa gaccuc 36ggucuaccug augaggccgu uaggccgaaa gaccuc 36

＜210＞ 46<210> 46

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 46<400> 46

cacgguccug augaggccgu uaggccgaaa cgagac 36cacgguccug augaggccgu uaggccgaaa cgagac 36

＜210＞ 47<210> 47

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 47<400> 47

uuucuuucug augaggccgu uaggccgaaa gguuua 36uuucuuucug augaggccgu uaggccgaaa gguuua 36

＜210＞ 48<210> 48

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 48<400> 48

uuggugucug augaggccgu uaggccgaaa cguuug 36uuggugucug augaggccgu uaggccgaaa cguuug 36

＜210＞ 49<210> 49

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 49<400> 49

ugugggccug augaggccgu uaggccgaaa cgguug 36ugugggccug augaggccgu uaggccgaaa cgguug 36

＜210＞ 50<210> 50

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 50<400> 50

agguugucug augaggccgu uaggccgaaa ccgcuc 36agguugucug augaggccgu uaggccgaaa ccgcuc 36

＜210＞ 51<210> 51

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 51<400> 51

uaucgaucug augaggccgu uaggccgaaa ccuuac 36uaucgaucug augaggccgu uaggccgaaa ccuuac 36

＜210＞ 52<210> 52

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 52<400> 52

aaaaaaacug augaggccgu uaggccgaaa aaaaaa 36aaaaaaacug augaggccgu uaggccgaaa aaaaaa 36

＜210＞ 53<210> 53

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 53<400> 53

uaagaugcug augaggccgu uaggccgaaa gccacc 36uaagaugcug augaggccgu uaggccgaaa gccacc 36

＜210＞ 54<210> 54

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 54<400> 54

gggcuaacug augaggccgu uaggccgaaa uggagc 36gggcuaacug augaggccgu uaggccgaaa uggagc 36

＜210＞ 55<210> 55

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 55<400> 55

uagggcucug augaggccgu uaggccgaaa gaugga 36uagggcucug augaggccgu uaggccgaaa gaugga 36

＜210＞ 56<210> 56

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 56<400> 56

cuagggccug augaggccgu uaggccgaaa agaugg 36cuagggccug augaggccgu uaggccgaaa agaugg 36

＜210＞ 57<210> 57

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 57<400> 57

ccgugaccug augaggccgu uaggccgaaa gggcua 36ccgugaccug augaggccgu uaggccgaaa gggcua 36

＜210＞ 58<210> 58

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 58<400> 58

uagccgucug augaggccgu uaggccgaaa cuaggg 36uagccgucug augaggccgu uaggccgaaa cuaggg 36

＜210＞ 59<210> 59

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 59<400> 59

ucacagccug augaggccgu uaggccgaaa gccgug 36ucacagccug augaggccgu uaggccgaaa gccgug 36

＜210＞ 60<210> 60

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 60<400> 60

gcucacgcug augaggccgu uaggccgaaa ccuuuc 36gcucacgcug augaggccgu uaggccgaaa ccuuuc 36

＜210＞ 61<210> 61

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 61<400> 61

uauggugcug augagncgaa agugucg 27uauggugcug augagncgaa agugucg 27

＜210＞ 62<210> 62

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 62<400> 62

gguccugcug augagncgaa aggcugc 27gguccugcug augagncgaa aggcugc 27

＜210＞ 63<210> 63

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 63<400> 63

cucccggcug augagncgaa agggggg 27cucccggcug augagncgaa agggggg 27

＜210＞ 64<210> 64

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 64<400> 64

uuccgcacug augagncgaa accacua 27uuccgcacug augagncgaa accacua 27

＜210＞ 65<210> 65

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 65<400> 65

uccggugcug augagncgaa acucacc 27uccggugcug augagncgaa acucacc 27

＜210＞ 66<210> 66

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 66<400> 66

uccuggccug augagncgaa auuccgg 27uccuggccug augagncgaa auuccgg 27

＜210＞ 67<210> 67

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 67<400> 67

uugaucccug augagncgaa agaaagg 27uugaucccug augagncgaa agaaagg 27

＜210＞ 68<210> 68

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 68<400> 68

aggcauucug augagncgaa agcgggu 27aggcauucug augagncgaa agcgggu 27

＜210＞ 69<210> 69

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 69<400> 69

acucggccug augagncgaa agcaguc 27acucggccug augagncgaa agcaguc 27

＜210＞ 70<210> 70

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 70<400> 70

ccaacaccug augagncgaa acucggc 27ccaacaccug augagncgaa acucggc 27

＜210＞ 71<210> 71

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 71<400> 71

gcgaccccug augagncgaa acacuac 27gcgaccccug augagncgaa acacuac 27

＜210＞ 72<210> 72

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 72<400> 72

cuuucgccug augagncgaa acccaac 27cuuucgccug augagncgaa acccaac 27

＜210＞ 73<210> 73

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 73<400> 73

caggcagcug augagncgaa accacaa 27caggcagcug augagncgaa accacaa 27

＜210＞ 74<210> 74

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 74<400> 74

agcaccccug augagncgaa aucaggc 27agcaccccug augagncgaa aucaggc 27

＜210＞ 75<210> 75

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 75<400> 75

cacucgccug augagncgaa agcaccc 27cacucgccug augagncgaa agcaccc 27

＜210＞ 76<210> 76

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 76<400> 76

ucuacgacug augagncgaa accuccc 27ucuacgacug augagncgaa accuccc 27

＜210＞ 77<210> 77

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 77<400> 77

ggucuaccug augagncgaa agaccuc 27ggucuaccug augagncgaa agaccuc 27

＜210＞ 78<210> 78

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 78<400> 78

cacgguccug augagncgaa acgagac 27cacgguccug augagncgaa acgagac 27

＜210＞ 79<210> 79

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 79<400> 79

ggaacuucug augagncgaa acguccu 27ggaacuucug augagncgaa acguccu 27

＜210＞ 80<210> 80

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 80<400> 80

gcccgggcug augagncgaa acuugac 27gcccgggcug augagncgaa acuugac 27

＜210＞ 81<210> 81

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 81<400> 81

cgcccggcug augagncgaa aacuuga 27cgcccggcug augagncgaa aacuuga 27

＜210＞ 82<210> 82

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 82<400> 82

acgaucucug augagncgaa accaccg 27acgaucucug augagncgaa accaccg 27

＜210＞ 83<210> 83

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 83<400> 83

cacaccccug augagncgaa acguggg 27cacaccccug augagncgaa acguggg 27

＜210＞ 84<210> 84

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 84<400> 84

gucuucccug augagncgaa agucgcg 27gucuucccug augagncgaa agucgcg 27

＜210＞ 85<210> 85

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 85<400> 85

cguucggcug augagncgaa agucuuc 27cguucggcug augagncgaa agucuuc 27

＜210＞ 86<210> 86

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 86<400> 86

ccguucgcug augagncgaa aagucuu 27ccguucgcug augagncgaa aagucuu 27

＜210＞ 87<210> 87

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 87<400> 87

agguugccug augagncgaa accguuc 27agguugccug augagncgaa accguuc 27

＜210＞ 88<210> 88

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 88<400> 88

uuggggacug augagncgaa agguugu 27uuggggacug augagncgaa agguugu 27

＜210＞ 89<210> 89

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 89<400> 89

ccuugggcug augagncgaa auagguu 27ccuugggcug augagncgaa auagguu 27

＜210＞ 90<210> 90

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 90<400> 90

ggucggccug augagncgaa agccuug 27ggucggccug augagncgaa agccuug 27

＜210＞ 91<210> 91

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 91<400> 91

caggccccug augagncgaa acccucg 27caggccccug augagncgaa acccucg 27

＜210＞ 92<210> 92

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 92<400> 92

ccaggcucug augagncgaa agcccag 27ccaggcucug augagncgaa agcccag 27

＜210＞ 93<210> 93

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 93<400> 93

ccaagggcug augagncgaa acccagg 27ccaagggcug augagncgaa acccagg 27

＜210＞ 94<210> 94

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 94<400> 94

aggggcccug augagncgaa aggguac 27aggggcccug augagncgaa aggguac 27

＜210＞ 95<210> 95

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 95<400> 95

ugccauacug augagncgaa aggggcc 27ugccauacug augagncgaa aggggcc 27

＜210＞ 96<210> 96

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 96<400> 96

auugccacug augagncgaa agagggg 27auugccacug augagncgaa agagggg 27

＜210＞ 97<210> 97

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 97<400> 97

gugacagcug augagncgaa agccauc 27gugacagcug augagncgaa agccauc 27

＜210＞ 98<210> 98

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 98<400> 98

gcggggucug augagncgaa acaggag 27gcggggucug augagncgaa acaggag 27

＜210＞ 99<210> 99

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 99<400> 99

aggccggcug augagncgaa agccgcg 27aggccggcug augagncgaa agccgcg 27

＜210＞ 100<210> 100

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 100<400> 100

ccccaaccug augagncgaa aggccgg 27ccccaaccug augagncgaa aggccgg 27

＜210＞ 101<210> 101

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 101<400> 101

gggcccccug augagncgaa acuaggc 27gggcccccug augagncgaa acuaggc 27

＜210＞ 102<210> 102

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 102<400> 102

uuacccacug augagncgaa auugcgc 27uuacccacug augagncgaa auugcgc 27

＜210＞ 103<210> 103

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 103<400> 103

uaucgaucug augagncgaa accuuac 27uaucgaucug augagncgaa accuuac 27

＜210＞ 104<210> 104

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 104<400> 104

ggguauccug augagncgaa augaccu 27ggguauccug augagncgaa augaccu 27

＜210＞ 105<210> 105

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 105<400> 105

gugagggcug augagncgaa aucgaug 27gugagggcug augagncgaa aucgaug 27

＜210＞ 106<210> 106

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 106<400> 106

gucggcgcug augagncgaa agccgca 27gucggcgcug augagncgaa agccgca 27

＜210＞ 107<210> 107

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 107<400> 107

ggucggccug augagncgaa aagccgc 27ggucggccug augagncgaa aagccgc 27

＜210＞ 108<210> 108

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 108<400> 108

cggaaugcug augagncgaa accccau 27cggaaugcug augagncgaa accccau 27

＜210＞ 109<210> 109

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 109<400> 109

cgagcggcug augagncgaa auguacc 27cgagcggcug augagncgaa auguacc 27

＜210＞ 110<210> 110

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 110<400> 110

acgagcgcug augagncgaa aauguac 27acgagcgcug augagncgaa aauguac 27

＜210＞ 111<210> 111

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 111<400> 111

cgccgaccug augagncgaa agcggaa 27cgccgaccug augagncgaa agcggaa 27

＜210＞ 112<210> 112

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 112<400> 112

gggcgcccug augagncgaa acgagcg 27gggcgcccug augagncgaa acgagcg 27

＜210＞ 113<210> 113

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 113<400> 113

cgccccccug augagncgaa agggggg 27cgccccccug augagncgaa agggggg 27

＜210＞ 114<210> 114

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 114<400> 114

gaacccgcug augagncgaa acaccau 27gaacccgcug augagncgaa acaccau 27

＜210＞ 115<210> 115

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 115<400> 115

ccuccagcug augagncgaa acccgga 27ccuccagcug augagncgaa acccgga 27

＜210＞ 116<210> 116

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 116<400> 116

uccuccacug augagncgaa aacccgg 27uccuccacug augagncgaa aacccgg 27

＜210＞ 117<210> 117

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 117<400> 117

uguugcgcug augagncgaa aguucac 27uguugcgcug augagncgaa aguucac 27

＜210＞ 118<210> 118

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 118<400> 118

accgggccug augagncgaa aguuccc 27accgggccug augagncgaa aguuccc 27

＜210＞ 119<210> 119

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 119<400> 119

aaagagccug augagncgaa accgggc 27aaagagccug augagncgaa accgggc 27

＜210＞ 120<210> 120

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 120<400> 120

agagaaacug augagncgaa agcaacc 27agagaaacug augagncgaa agcaacc 27

＜210＞ 121<210> 121

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 121<400> 121

ugccucacug augagncgaa acacaau 27ugccucacug augagncgaa acacaau 27

＜210＞ 122<210> 122

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 122<400> 122

uaugcaucug augagncgaa aucaugc 27uaugcaucug augagncgaa aucaugc 27

＜210＞ 123<210> 123

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 123<400> 123

cgcagggcug augagncgaa acgcacc 27cgcagggcug augagncgaa acgcacc 27

＜210＞ 124<210> 124

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 124<400> 124

ucucccgcug augagncgaa acgcagg 27ucucccgcug augagncgaa acgcagg 27

＜210＞ 125<210> 125

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 125<400> 125

uucuccccug augagncgaa aacgcag 27uucuccccug augagncgaa aacgcag 27

＜210＞ 126<210> 126

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 126<400> 126

acaacggcug augagncgaa aggcguu 27acaacggcug augagncgaa aggcguu 27

＜210＞ 127<210> 127

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 127<400> 127

acccaaccug augagncgaa acgggag 27acccaaccug augagncgaa acgggag 27

＜210＞ 128<210> 128

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 128<400> 128

gcuaccccug augagncgaa acaacgg 27gcuaccccug augagncgaa acaacgg 27

＜210＞ 129<210> 129

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 129<400> 129

ugagcgccug augagncgaa acccaac 27ugagcgccug augagncgaa acccaac 27

＜210＞ 130<210> 130

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 130<400> 130

gcaaguccug augagncgaa acguggc 27gcaaguccug augagncgaa acguggc 27

＜210＞ 131<210> 131

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 131<400> 131

aacgagccug augagncgaa agucgac 27aacgagccug augagncgaa agucgac 27

＜210＞ 132<210> 132

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 132<400> 132

ccccaaccug augagncgaa agcaagu 27ccccaaccug augagncgaa agcaagu 27

＜210＞ 133<210> 133

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 133<400> 133

ccgcccccug augagncgaa acgagca 27ccgcccccug augagncgaa acgagca 27

＜210＞ 134<210> 134

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 134<400> 134

ggaacagcug augagncgaa aagcggc 27ggaacagcug augagncgaa aagcggc 27

＜210＞ 135<210> 135

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 135<400> 135

cggaacacug augagncgaa aaagcgg 27cggaacacug augagncgaa aaagcgg 27

＜210＞ 136<210> 136

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 136<400> 136

auggcggcug augagncgaa acagaaa 27auggcggcug augagncgaa acagaaa 27

＜210＞ 137<210> 137

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 137<400> 137

cauggcgcug augagncgaa aacagaa 27cauggcgcug augagncgaa aacagaa 27

＜210＞ 138<210> 138

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 138 ccccacgcug augagncgaa acauggc 27<400> 138 ccccacgcug augagncgaa acauggc 27

＜210＞ 139<210> 139

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 139<400> 139

gaaaacgcug augagncgaa auccgca 27gaaaacgcug augagncgaa auccgca 27

＜210＞ 140<210> 140

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 140<400> 140

cgaggaacug augagncgaa acggauc 27cgaggaacug augagncgaa acggauc 27

＜210＞ 141<210> 141

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 141<400> 141

acgaggacug augagncgaa aacggau 27acgaggacug augagncgaa aacggau 27

＜210＞ 142<210> 142

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 142<400> 142

gacgaggcug augagncgaa aaacgga 27gacgaggcug augagncgaa aaacgga 27

＜210＞ 143<210> 143

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 143<400> 143

agacgagcug augagncgaa aaaacgg 27agacgagcug augagncgaa aaaacgg 27

＜210＞ 144<210> 144

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 144<400> 144

gaccugacug augagncgaa acauggc 27gaccugacug augagncgaa acauggc 27

＜210＞ 145<210> 145

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 145<400> 145

gugaccucug augagncgaa auacaug 27gugaccucug augagncgaa auacaug 27

＜210＞ 146<210> 146

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 146<400> 146

augcggucug augagncgaa accugau 27augcggucug augagncgaa accugau 27

＜210＞ 147<210> 147

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 147<400> 147

uauccaccug augagncgaa acagcuu 27uauccaccug augagncgaa acagcuu 27

＜210＞ 148<210> 148

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 148<400> 148

gccaccacug augagncgaa auccacg 27gccaccacug augagncgaa auccacg 27

＜210＞ 149<210> 149

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 149<400> 149

ccgcuagcug augagncgaa acucccc 27ccgcuagcug augagncgaa acucccc 27

＜210＞ 150<210> 150

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 150<400> 150

ggcccgccug augagncgaa aggacuc 27ggcccgccug augagncgaa aggacuc 27

＜210＞ 151<210> 151

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 151<400> 151

aguaggccug augagncgaa aggcccg 27aguaggccug augagncgaa aggcccg 27

＜210＞ 152<210> 152

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 152<400> 152

ggaauagcug augagncgaa aggcaag 27ggaauagcug augagncgaa aggcaag 27

＜210＞ 153<210> 153

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 153<400> 153

cauggaacug augagncgaa aguaggc 27cauggaacug augagncgaa aguaggc 27

＜210＞ 154<210> 154

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 154<400> 154

accauggcug augagncgaa auaguag 27accauggcug augagncgaa auaguag 27

＜210＞ 155<210> 155

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 155<400> 155

caccaugcug augagncgaa aauagua 27caccaugcug augagncgaa aauagua 27

＜210＞ 156<210> 156

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 156<400> 156

acuuguccug augagncgaa auggagc 27acuuguccug augagncgaa auggagc 27

＜210＞ 157<210> 157

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 157<400> 157

cugagcgcug augagncgaa acuuguc 27cugagcgcug augagncgaa acuuguc 27

＜210＞ 158<210> 158

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 158<400> 158

ccugagccug augagncgaa aacuugu 27ccugagccug augagncgaa aacuugu 27

＜210＞ 159<210> 159

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 159<400> 159

caucccucug augagncgaa agcgaac 27caucccucug augagncgaa agcgaac 27

＜210＞ 160<210> 160

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 160<400> 160

uauaggucug augagncgaa auggggc 27uauaggucug augagncgaa auggggc 27

＜210＞ 161<210> 161

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 161<400> 161

cucgguacug augagncgaa aggugau 27cucgguacug augagncgaa aggugau 27

＜210＞ 162<210> 162

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 162<400> 162

ccagcagcug augagncgaa aaggccu 27ccagcagcug augagncgaa aaggccu 27

＜210＞ 163<210> 163

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 163<400> 163

ggugcgucug augagncgaa augccag 27ggugcgucug augagncgaa augccag 27

＜210＞ 164<210> 164

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 164<400> 164

aggugcgcug augagncgaa aaugcca 27aggugcgcug augagncgaa aaugcca 27

＜210＞ 165<210> 165

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 165<400> 165

cacugcccug augagncgaa aggugcg 27cacugcccug augagncgaa aggugcg 27

＜210＞ 166<210> 166

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 166<400> 166

gguacgacug augagncgaa accacac 27gguacgacug augagncgaa accacac 27

＜210＞ 167<210> 167

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 167<400> 167

cagguaccug augagncgaa auaccac 27cagguaccug augagncgaa auaccac 27

＜210＞ 168<210> 168

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 168<400> 168

acgcaggcug augagncgaa acgauac 27acgcaggcug augagncgaa acgauac 27

＜210＞ 169<210> 169

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 169<400> 169

caccugccug augagncgaa acgcagg 27caccugccug augagncgaa acgcagg 27

＜210＞ 170<210> 170

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 170<400> 170

uacacugcug augagncgaa accacac 27uacacugcug augagncgaa accacac 27

＜210＞ 171<210> 171

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 171<400> 171

ccacuaccug augagncgaa acagggc 27ccacuaccug augagncgaa acagggc 27

＜210＞ 172<210> 172

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 172<400> 172

uccccaccug augagncgaa acaacag 27uccccaccug augagncgaa acaacag 27

＜210＞ 173<210> 173

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 173<400> 173

ccggacccug augagncgaa aucgguc 27ccggacccug augagncgaa aucgguc 27

＜210＞ 174<210> 174

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 174<400> 174

ggcaccgcug augagncgaa accgauc 27ggcaccgcug augagncgaa accgauc 27

＜210＞ 175<210> 175

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 175<400> 175

uuauacgcug augagncgaa aggggca 27uuauacgcug augagncgaa aggggca 27

＜210＞ 176<210> 176

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 176<400> 176

ccaguuacug augagncgaa acguagg 27ccaguuacug augagncgaa acguagg 27

＜210＞ 177<210> 177

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 177<400> 177

ccccagucug augagncgaa auacgua 27ccccagucug augagncgaa auacgua 27

＜210＞ 178<210> 178

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 178<400> 178

acagccacug augagncgaa accaguu 27acagccacug augagncgaa accaguu 27

＜210＞ 179<210> 179

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 179<400> 179

uacagcccug augagncgaa aaccagu 27uacagcccug augagncgaa aaccagu 27

＜210＞ 180<210> 180

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 180<400> 180

auccaugcug augagncgaa acagcca 27auccaugcug augagncgaa acagcca 27

＜210＞ 181<210> 181

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 181<400> 181

uugcacgcug augagncgaa agggccc 27uugcacgcug augagncgaa agggccc 27

＜210＞ 182<210> 182

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 182<400> 182

ccccccccug augagncgaa auguugc 27ccccccccug augagncgaa auguugc 27

＜210＞ 183<210> 183

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 183<400> 183

gguugcccug augagncgaa acccccc 27gguugcccug augagncgaa acccccc 27

＜210＞ 184<210> 184

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 184<400> 184

ucaaggucug augagncgaa agguugc 27ucaaggucug augagncgaa agguugc 27

＜210＞ 185<210> 185

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 185<400> 185

gcagguccug augagncgaa aggugag 27gcagguccug augagncgaa aggugag 27

＜210＞ 186<210> 186

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 186<400> 186

uuugugucug augagncgaa aguggcc 27uuugugucug augagncgaa aguggcc 27

＜210＞ 187<210> 187

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 187<400> 187

uuuugugcug augagncgaa aaguggc 27uuuugugcug augagncgaa aaguggc 27

＜210＞ 188<210> 188

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 188<400> 188

uggcccccug augagncgaa agccaca 27uggcccccug augagncgaa agccaca 27

＜210＞ 189<210> 189

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 189<400> 189

agguguucug augagncgaa accaugg 27agguguucug augagncgaa accaugg 27

＜210＞ 190<210> 190

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 190<400> 190

uaggugucug augagncgaa aaccaug 27uaggugucug augagncgaa aaccaug 27

＜210＞ 191<210> 191

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 191<400> 191

ccuuaaacug augagncgaa augguaa 27ccuuaaacug augagncgaa augguaa 27

＜210＞ 192<210> 192

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 192<400> 192

aaccuuacug augagncgaa agauggu 27aaccuuacug augagncgaa agauggu 27

＜210＞ 193<210> 193

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 193<400> 193

cagcacucug augagncgaa agccugu 27cagcacucug augagncgaa agccugu 27

＜210＞ 194<210> 194

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 194<400> 194

gcagcaccug augagncgaa aagccug 27gcagcaccug augagncgaa aagccug 27

＜210＞ 195<210> 195

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 195<400> 195

aggucgccug augagncgaa acgcucu 27aggucgccug augagncgaa acgcucu 27

＜210＞ 196<210> 196

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 196<400> 196

gagcucccug augagncgaa aucuguc 27gagcucccug augagncgaa aucuguc 27

＜210＞ 197<210> 197

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 197<400> 197

gcgggcucug augagncgaa agcuccg 27gcgggcucug augagncgaa agcuccg 27

＜210＞ 198<210> 198

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 198<400> 198

ugucgugcug augagncgaa acagcag 27ugucgugcug augagncgaa acagcag 27

＜210＞ 199<210> 199

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 199<400> 199

ucugaugcug augagncgaa aggugga 27ucugaugcug augagncgaa aggugga 27

＜210＞ 200<210> 200

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 200<400> 200

auguucucug augagncgaa auggagg 27auguucucug augagncgaa auggagg 27

＜210＞ 201<210> 201

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 201<400> 201

cguccaccug augagncgaa auguucu 27cguccaccug augagncgaa auguucu 27

＜210＞ 202<210> 202

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 202<400> 202

aggcacacug augagncgaa acgcgcg 27aggcacacug augagncgaa acgcgcg 27

＜210＞ 203<210> 203

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 203<400> 203

gguucuccug augagncgaa agggcgg 27gguucuccug augagncgaa agggcgg 27

＜210＞ 204<210> 204

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 204<400> 204

cguugagcug augagncgaa accacca 27cguugagcug augagncgaa accacca 27

＜210＞ 205<210> 205

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 205<400> 205

ccgcguucug augagncgaa aggacca 27ccgcguucug augagncgaa aggacca 27

＜210＞ 206<210> 206

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 206<400> 206

cuugaugcug augagncgaa accaggc 27cuugaugcug augagncgaa accaggc 27

＜210＞ 207<210> 207

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 207<400> 207

ugcccuucug augagncgaa auguacc 27ugcccuucug augagncgaa auguacc 27

＜210＞ 208<210> 208

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 208<400> 208

ccccaggcug augagncgaa accagcc 27ccccaggcug augagncgaa accagcc 27

＜210＞ 209<210> 209

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 209<400> 209

cagagcacug augagncgaa augccgc 27cagagcacug augagncgaa augccgc 27

＜210＞ 210<210> 210

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 210<400> 210

ccguacacug augagncgaa agcauau 27ccguacacug augagncgaa agcauau 27

＜210＞ 211<210> 211

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 211<400> 211

cacgccgcug augagncgaa acagagc 27cacgccgcug augagncgaa acagagc 27

＜210＞ 212<210> 212

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 212<400> 212

ccagcagcug augagncgaa agcagga 27ccagcagcug augagncgaa agcagga 27

＜210＞ 213<210> 213

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 213<400> 213

auggcgucug augagncgaa agcccgu 27auggcgucug augagncgaa agcccgu 27

＜210＞ 214<210> 214

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 214<400> 214

cauggcgcug augagncgaa aagcccg 27cauggcgcug augagncgaa aagcccg 27

＜210＞ 215<210> 215

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 215<400> 215

guauugucug augagncgaa accacca 27guauugucug augagncgaa accacca 27

＜210＞ 216<210> 216

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 216<400> 216

aguauugcug augagncgaa aaccacc 27aguauugcug augagncgaa aaccacc 27

＜210＞ 217<210> 217

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 217<400> 217

gauaaagcug augagncgaa auuguaa 27gauaaagcug augagncgaa auuguaa 27

＜210＞ 218<210> 218

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 218<400> 218

ggugauacug augagncgaa aguauug 27ggugauacug augagncgaa aguauug 27

＜210＞ 219<210> 219

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 219<400> 219

uggugaucug augagncgaa aaguauu 27uggugaucug augagncgaa aaguauu 27

＜210＞ 220<210> 220

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 220<400> 220

acgcacacug augagncgaa augcgcc 27acgcacacug augagncgaa augcgcc 27

＜210＞ 221<210> 221

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 221<400> 221

cacgcaccug augagncgaa aaugcgc 27cacgcaccug augagncgaa aaugcgc 27

＜210＞ 222<210> 222

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 222<400> 222

gagggggcug augagncgaa acccaca 27gagggggcug augagncgaa acccaca 27

＜210＞ 223<210> 223

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 223<400> 223

acauugacug augagncgaa agggggg 27acauugacug augagncgaa agggggg 27

＜210＞ 224<210> 224

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 224<400> 224

ggacauucug augagncgaa agagggg 27ggacauucug augagncgaa agagggg 27

＜210＞ 225<210> 225

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 225<400> 225

ccccccgcug augagncgaa acauuga 27ccccccgcug augagncgaa acauuga 27

＜210＞ 226<210> 226

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 226<400> 226

aggaugacug augagncgaa agcaucg 27aggaugacug augagncgaa agcaucg 27

＜210＞ 227<210> 227

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 227<400> 227

ggaggaucug augagncgaa auagcau 27ggaggaucug augagncgaa auagcau 27

＜210＞ 228<210> 228

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 228<400> 228

ugaggagcug augagncgaa augauag 27ugaggagcug augagncgaa augauag 27

＜210＞ 229<210> 229

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 229<400> 229

augugagcug augagncgaa aggauga 27augugagcug augagncgaa aggauga 27

＜210＞ 230<210> 230

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 230<400> 230

cacaugucug augagncgaa aggagga 27cacaugucug augagncgaa aggagga 27

＜210＞ 231<210> 231

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 231<400> 231

ucgcagucug augagncgaa auggcag 27ucgcagucug augagncgaa auggcag 27

＜210＞ 232<210> 232

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 232<400> 232

uggacgucug augagncgaa auggccu 27uggacgucug augagncgaa auggccu 27

＜210＞ 233<210> 233

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 233<400> 233

uuggacgcug augagncgaa aauggcc 27uuggacgcug augagncgaa aauggcc 27

＜210＞ 234<210> 234

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 234<400> 234

ccauuugcug augagncgaa acguaau 27ccauuugcug augagncgaa acguaau 27

＜210＞ 235<210> 235

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 235<400> 235

cuucaugcug augagncgaa aggccau 27cuucaugcug augagncgaa aggccau 27

＜210＞ 236<210> 236

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 236<400> 236

gcuucaucug augagncgaa aaggcca 27gcuucaucug augagncgaa aaggcca 27

＜210＞ 237<210> 237

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 237<400> 237

aauccugcug augagncgaa agcgggg 27aauccugcug augagncgaa agcgggg 27

＜210＞ 238<210> 238

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 238<400> 238

ugggccccug augagncgaa auccugu 27ugggccccug augagncgaa auccugu 27

＜210＞ 239<210> 239

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 239<400> 239

ggucucgcug augagncgaa aggcccg 27ggucucgcug augagncgaa aggcccg 27

＜210＞ 240<210> 240

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 240<400> 240

ccaccgccug augagncgaa aggucuc 27ccaccgccug augagncgaa aggucuc 27

＜210＞ 241<210> 241

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 241<400> 241

agaagaccug augagncgaa acgggcu 27agaagaccug augagncgaa acgggcu 27

＜210＞ 242<210> 242

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 242<400> 242

cagagaacug augagncgaa acgacgg 27cagagaacug augagncgaa acgacgg 27

＜210＞ 243<210> 243

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 243<400> 243

gucagagcug augagncgaa agacgac 27gucagagcug augagncgaa agacgac 27

＜210＞ 244<210> 244

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 244<400> 244

aggugaucug augagncgaa aucuugg 27aggugaucug augagncgaa aucuugg 27

＜210＞ 245<210> 245

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 245<400> 245

cccaggucug augagncgaa augaucu 27cccaggucug augagncgaa augaucu 27

＜210＞ 246<210> 246

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 246<400> 246

ccaagaucug augagncgaa auguccc 27ccaagaucug augagncgaa auguccc 27

＜210＞ 247<210> 247

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 247<400> 247

gucccaacug augagncgaa augaugu 27gucccaacug augagncgaa augaugu 27

＜210＞ 248<210> 248

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 248<400> 248

caguccccug augagncgaa agaugau 27caguccccug augagncgaa agaugau 27

＜210＞ 249<210> 249

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 249<400> 249

gggcggacug augagncgaa acgggca 27gggcggacug augagncgaa acgggca 27

＜210＞ 250<210> 250

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 250<400> 250

ucgggcgcug augagncgaa agacggg 27ucgggcgcug augagncgaa agacggg 27

＜210＞ 251<210> 251

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 251<400> 251

ccagaagcug augagncgaa aucuccc 27ccagaagcug augagncgaa aucuccc 27

＜210＞ 252<210> 252

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 252<400> 252

gggcaagcug augagncgaa agucgcc 27gggcaagcug augagncgaa agucgcc 27

＜210＞ 253<210> 253

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 253<400> 253

ugggggccug augagncgaa aggaguc 27ugggggccug augagncgaa aggaguc 27

＜210＞ 254<210> 254

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 254<400> 254

aggccgucug augagncgaa auggggg 27aggccgucug augagncgaa auggggg 27

＜210＞ 255<210> 255

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 255<400> 255

ggccugucug augagncgaa aggcuag 27ggccugucug augagncgaa aggcuag 27

＜210＞ 256<210> 256

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 256<400> 256

ccacuugcug augagncgaa accuccc 27ccacuugcug augagncgaa accuccc 27

＜210＞ 257<210> 257

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 257<400> 257

accacuucug augagncgaa aaccucc 27accacuucug augagncgaa aaccucc 27

＜210＞ 258<210> 258

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 258<400> 258

cgguggacug augagncgaa accacuu 27cgguggacug augagncgaa accacuu 27

＜210＞ 259<210> 259

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 259<400> 259

gcgguggcug augagncgaa aaccacu 27gcgguggcug augagncgaa aaccacu 27

＜210＞ 260<210> 260

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 260<400> 260

ugcggugcug augagncgaa aaaccac 27ugcggugcug augagncgaa aaaccac 27

＜210＞ 261<210> 261

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 261<400> 261

acggucccug augagncgaa acacaca 27acggucccug augagncgaa acacaca 27

＜210＞ 262<210> 262

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 262<400> 262

ggucuuucug augagncgaa agccggc 27ggucuuucug augagncgaa agccggc 27

＜210＞ 263<210> 263

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 263<400> 263

ggccggccug augagncgaa agggucu 27ggccggccug augagncgaa agggucu 27

＜210＞ 264<210> 264

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 264<400> 264

gccccggcug augagncgaa aggcgca 27gccccggcug augagncgaa aggcgca 27

＜210＞ 265<210> 265

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 265<400> 265

guaagggcug augagncgaa acgcgcc 27guaagggcug augagncgaa acgcgcc 27

＜210＞ 266<210> 266

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 266<400> 266

uguaaggcug augagncgaa aacgcgc 27uguaaggcug augagncgaa aacgcgc 27

＜210＞ 267<210> 267

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 267<400> 267

auggugucug augagncgaa agggaac 27auggugucug augagncgaa agggaac 27

＜210＞ 268<210> 268

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 268<400> 268

cauggugcug augagncgaa aagggaa 27cauggugcug augagncgaa aagggaa 27

＜210＞ 269<210> 269

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 269<400> 269

gaggucccug augagncgaa agcuacc 27gaggucccug augagncgaa agcuacc 27

＜210＞ 270<210> 270

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 270<400> 270

ccagauacug augagncgaa agguccg 27ccagauacug augagncgaa agguccg 27

＜210＞ 271<210> 271

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 271<400> 271

gaccagacug augagncgaa agagguc 27gaccagacug augagncgaa agagguc 27

＜210＞ 272<210> 272

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 272<400> 272

gugaccacug augagncgaa auagagg 27gugaccacug augagncgaa auagagg 27

＜210＞ 273<210> 273

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 273<400> 273

gucucgucug augagncgaa accagau 27gucucgucug augagncgaa accagau 27

＜210＞ 274<210> 274

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 274<400> 274

gcaccggcug augagncgaa augacgu 27gcaccggcug augagncgaa augacgu 27

＜210＞ 275<210> 275

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 275<400> 275

cgcaccgcug augagncgaa aaugacg 27cgcaccgcug augagncgaa aaugacg 27

＜210＞ 276<210> 276

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 276<400> 276

cuccccccug augagncgaa accguca 27cuccccccug augagncgaa accguca 27

＜210＞ 277<210> 277

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 277<400> 277

gggacagcug augagncgaa aggcucc 27gggacagcug augagncgaa aggcucc 27

＜210＞ 278<210> 278

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 278<400> 278

ucuggggcug augagncgaa acaguag 27ucuggggcug augagncgaa acaguag 27

＜210＞ 279<210> 279

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 279<400> 279

gccaccccug augagncgaa aagagcc 27gccaccccug augagncgaa aagagcc 27

＜210＞ 280<210> 280

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 280<400> 280

aagggcacug augagncgaa agcagug 27aagggcacug augagncgaa agcagug 27

＜210＞ 281<210> 281

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 281<400> 281

ugccccgcug augagncgaa agggcag 27ugccccgcug augagncgaa agggcag 27

＜210＞ 282<210> 282

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 282<400> 282

gugcccccug augagncgaa aagggca 27gugcccccug augagncgaa aagggca 27

＜210＞ 283<210> 283

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 283<400> 283

agaugcccug augagncgaa acagcgu 27agaugcccug augagncgaa acagcgu 27

＜210＞ 284<210> 284

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 284<400> 284

cccggaacug augagncgaa augccua 27cccggaacug augagncgaa augccua 27

＜210＞ 285<210> 285

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 285<400> 285

agcccggcug augagncgaa agaugcc 27agcccggcug augagncgaa agaugcc 27

＜210＞ 286<210> 286

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 286<400> 286

cagcccgcug augagncgaa aagaugc 27cagcccgcug augagncgaa aagaugc 27

＜210＞ 287<210> 287

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 287<400> 287

ccuucgccug augagncgaa acccccc 27ccuucgccug augagncgaa acccccc 27

＜210＞ 288<210> 288

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 288<400> 288

ggcacuucug augagncgaa agugcuc 27ggcacuucug augagncgaa agugcuc 27

＜210＞ 289<210> 289

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 289<400> 289

ggcugcgcug augagncgaa acgcagc 27ggcugcgcug augagncgaa acgcagc 27

＜210＞ 290<210> 290

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 290<400> 290

uaccuugcug augagncgaa acccuug 27uaccuugcug augagncgaa acccuug 27

＜210＞ 291<210> 291

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 291<400> 291

uggcggccug augagncgaa acagaug 27uggcggccug augagncgaa acagaug 27

＜210＞ 292<210> 292

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 292<400> 292

caguucucug augagncgaa auguugg 27caguucucug augagncgaa auguugg 27

＜210＞ 293<210> 293

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 293<400> 293

ugguccucug augagncgaa accccag 27ugguccucug augagncgaa accccag 27

＜210＞ 294<210> 294

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 294<400> 294

cuuaccacug augagncgaa aggugga 27cuuaccacug augagncgaa aggugga 27

＜210＞ 295<210> 295

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 295<400> 295

aggaacucug augagncgaa accauag 27aggaacucug augagncgaa accauag 27

＜210＞ 296<210> 296

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 296<400> 296

ggcaaggcug augagncgaa acuuacc 27ggcaaggcug augagncgaa acuuacc 27

＜210＞ 297<210> 297

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 297<400> 297

cggcaagcug augagncgaa aacuuac 27cggcaagcug augagncgaa aacuuac 27

＜210＞ 298<210> 298

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 298<400> 298

cgucggccug augagncgaa aggaacu 27cgucggccug augagncgaa aggaacu 27

＜210＞ 299<210> 299

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 299<400> 299

cacauaucug augagncgaa augauau 27cacauaucug augagncgaa augauau 27

＜210＞ 300<210> 300

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 300<400> 300

caucacacug augagncgaa auuauga 27caucacacug augagncgaa auuauga 27

＜210＞ 301<210> 301

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 301<400> 301

gguccagcug augagncgaa acugugc 27gguccagcug augagncgaa acugugc 27

＜210＞ 302<210> 302

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 302<400> 302

gcacgaccug augagncgaa agccgcg 27gcacgaccug augagncgaa agccgcg 27

＜210＞ 303<210> 303

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 303<400> 303

cgagcaccug augagncgaa acgagcc 27cgagcaccug augagncgaa acgagcc 27

＜210＞ 304<210> 304

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 304<400> 304

cgguggccug augagncgaa agcacga 27cgguggccug augagncgaa agcacga 27

＜210＞ 305<210> 305

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 305<400> 305

uccucaacug augagncgaa auuuggg 27uccucaacug augagncgaa auuuggg 27

＜210＞ 306<210> 306

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 306<400> 306

aguguugcug augagncgaa acagagc 27aguguugcug augagncgaa acagagc 27

＜210＞ 307<210> 307

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 307<400> 307

agaagggcug augagncgaa aucucuc 27agaagggcug augagncgaa aucucuc 27

＜210＞ 308<210> 308

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 308<400> 308

cgaggggcug augagncgaa auggccu 27cgaggggcug augagncgaa auggccu 27

＜210＞ 309<210> 309

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 309<400> 309

uggccuccug augagncgaa aggggga 27uggccuccug augagncgaa aggggga 27

＜210＞ 310<210> 310

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 310<400> 310

cccccuucug augagncgaa auggccu 27cccccuucug augagncgaa auggccu 27

＜210＞ 311<210> 311

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 311<400> 311

cuucuugcug augagncgaa aguggca 27cuucuugcug augagncgaa aguggca 27

＜210＞ 312<210> 312

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 312<400> 312

cggcauucug augagncgaa auuccga 27cggcauucug augagncgaa auuccga 27

＜210＞ 313<210> 313

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 313<400> 313

aauacgccug augagncgaa acggcau 27aauacgccug augagncgaa acggcau 27

＜210＞ 314<210> 314

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 314<400> 314

ccgguaacug augagncgaa acgcuac 27ccgguaacug augagncgaa acgcuac 27

＜210＞ 315<210> 315

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 315<400> 315

ccccggucug augagncgaa auacgcu 27ccccggucug augagncgaa auacgcu 27

＜210＞ 316<210> 316

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 316<400> 316

accccggcug augagncgaa aauacgc 27accccggcug augagncgaa aauacgc 27

＜210＞ 317<210> 317

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 317<400> 317

ucgguaucug augagncgaa acggaca 27ucgguaucug augagncgaa acggaca 27

＜210＞ 318<210> 318

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 318<400> 318

uagucggcug augagncgaa augacgg 27uagucggcug augagncgaa augacgg 27

＜210＞ 319<210> 319

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 319<400> 319

ucuccgccug augagncgaa agucggu 27ucuccgccug augagncgaa agucggu 27

＜210＞ 320<210> 320

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 320<400> 320

accggugcug augagncgaa agcccgu 27accggugcug augagncgaa agcccgu 27

＜210＞ 321<210> 321

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 321<400> 321

ugcaguccug augagncgaa aucaccg 27ugcaguccug augagncgaa aucaccg 27

＜210＞ 322<210> 322

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 322<400> 322

ugagcgccug augagncgaa acaccgc 27ugagcgccug augagncgaa acaccgc 27

＜210＞ 323<210> 323

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 323<400> 323

ccguugucug augagncgaa agcgcga 27ccguugucug augagncgaa agcgcga 27

＜210＞ 324<210> 324

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 324<400> 324

ucauacccug augagncgaa agcacag 27ucauacccug augagncgaa agcacag 27

＜210＞ 325<210> 325

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 325<400> 325

gagcucacug augagncgaa accaagc 27gagcucacug augagncgaa accaagc 27

＜210＞ 326<210> 326

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 326<400> 326

cgggcgucug augagncgaa agcucau 27cgggcgucug augagncgaa agcucau 27

＜210＞ 327<210> 327

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 327<400> 327

cugacugcug augagncgaa agucuca 27cugacugcug augagncgaa agucuca 27

＜210＞ 328<210> 328

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 328<400> 328

gcaaccucug augagncgaa acuguag 27gcaaccucug augagncgaa acuguag 27

＜210＞ 329<210> 329

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 329<400> 329

agcccgccug augagncgaa accugac 27agcccgccug augagncgaa accugac 27

＜210＞ 330<210> 330

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 330<400> 330

uucaggucug augagncgaa agcccgc 27uucaggucug augagncgaa agcccgc 27

＜210＞ 331<210> 331

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 331<400> 331

auucaggcug augagncgaa aagcccg 27auucaggcug augagncgaa aagcccg 27

＜210＞ 332<210> 332

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 332<400> 332

ccuggugcug augagncgaa auucagg 27ccuggugcug augagncgaa auucagg 27

＜210＞ 333<210> 333

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 333<400> 333

gacgggccug augagncgaa acccugg 27gacgggccug augagncgaa acccugg 27

＜210＞ 334<210> 334

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 334<400> 334

ccuggcacug augagncgaa acgggca 27ccuggcacug augagncgaa acgggca 27

＜210＞ 335<210> 335

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 335<400> 335

aacuccacug augagncgaa auggucc 27aacuccacug augagncgaa auggucc 27

＜210＞ 336<210> 336

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 336<400> 336

gguaugccug augagncgaa accaggu 27gguaugccug augagncgaa accaggu 27

＜210＞ 337<210> 337

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 337<400> 337

ggcuuggcug augagncgaa augcuac 27ggcuuggcug augagncgaa augcuac 27

＜210＞ 338<210> 338

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 338<400> 338

ggagccucug augagncgaa agcccug 27ggagccucug augagncgaa agcccug 27

＜210＞ 339<210> 339

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 339<400> 339

uagccuacug augagncgaa acagcag 27uagccuacug augagncgaa acagcag 27

＜210＞ 340<210> 340

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 340<400> 340

ccuagcccug augagncgaa auacagc 27ccuagcccug augagncgaa auacagc 27

＜210＞ 341<210> 341

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 341<400> 341

uagugaccug augagncgaa accucca 27uagugaccug augagncgaa accucca 27

＜210＞ 342<210> 342

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 342<400> 342

ugcuagucug augagncgaa acgaccu 27ugcuagucug augagncgaa acgaccu 27

＜210＞ 343<210> 343

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 343<400> 343

caggugccug augagncgaa agugacg 27caggugccug augagncgaa agugacg 27

＜210＞ 344<210> 344

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 344<400> 344

cuccgcccug augagncgaa accagca 27cuccgcccug augagncgaa accagca 27

＜210＞ 345<210> 345

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 345<400> 345

cugcaagcug augagncgaa acuccgc 27cugcaagcug augagncgaa acuccgc 27

＜210＞ 346<210> 346

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 346<400> 346

gagcugccug augagncgaa aggacuc 27gagcugccug augagncgaa aggacuc 27

＜210＞ 347<210> 347

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 347<400> 347

caggcaacug augagncgaa augcggc 27caggcaacug augagncgaa augcggc 27

＜210＞ 348<210> 348

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 348<400> 348

gucaggccug augagncgaa auaugcg 27gucaggccug augagncgaa auaugcg 27

＜210＞ 349<210> 349

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 349<400> 349

accacaccug augagncgaa accgguu 27accacaccug augagncgaa accgguu 27

＜210＞ 350<210> 350

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 350<400> 350

acaaaaucug augagncgaa auccuac 27acaaaaucug augagncgaa auccuac 27

＜210＞ 351<210> 351

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 351<400> 351

cgggaaccug augagncgaa acagccg 27cgggaaccug augagncgaa acagccg 27

＜210＞ 352<210> 352

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 352<400> 352

ugucgggcug augagncgaa acaacag 27ugucgggcug augagncgaa acaacag 27

＜210＞ 353<210> 353

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 353<400> 353

cugucggcug augagncgaa aacaaca 27cugucggcug augagncgaa aacaaca 27

＜210＞ 354<210> 354

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 354<400> 354

cugcuugcug augagncgaa acugcuc 27cugcuugcug augagncgaa acugcuc 27

＜210＞ 355<210> 355

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 355<400> 355

ucugcuucug augagncgaa aacugcu 27ucugcuucug augagncgaa aacugcu 27

＜210＞ 356<210> 356

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 356<400> 356

accacggcug augagncgaa agcagcg 27accacggcug augagncgaa agcagcg 27

＜210＞ 357<210> 357

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 357<400> 357

ccaccugcug augagncgaa acuccac 27ccaccugcug augagncgaa acuccac 27

＜210＞ 358<210> 358

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 358<400> 358

aggccuccug augagncgaa agggccc 27aggccuccug augagncgaa agggccc 27

＜210＞ 359<210> 359

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 359<400> 359

ugcccagcug augagncgaa aggccuc 27ugcccagcug augagncgaa aggccuc 27

＜210＞ 360<210> 360

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 360<400> 360

uugcccacug augagncgaa aaggccu 27uugcccacug augagncgaa aaggccu 27

＜210＞ 361<210> 361

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 361<400> 361

aguggaucug augagncgaa agccugc 27aguggaucug augagncgaa agccugc 27

＜210＞ 362<210> 362

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 362<400> 362

gaguggacug augagncgaa aagccug 27gaguggacug augagncgaa aagccug 27

＜210＞ 363<210> 363

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 363<400> 363

gauguugcug augagncgaa acaggag 27gauguugcug augagncgaa acaggag 27

＜210＞ 364<210> 364

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 364<400> 364

agauguucug augagncgaa aacagga 27agauguucug augagncgaa aacagga 27

＜210＞ 365<210> 365

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 365<400> 365

gaggagccug augagncgaa aguugag 27gaggagccug augagncgaa aguugag 27

＜210＞ 366<210> 366

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 366<400> 366

cugggagcug augagncgaa agcgagu 27cugggagcug augagncgaa agcgagu 27

＜210＞ 367<210> 367

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 367<400> 367

gaaggcccug augagncgaa aagcagc 27gaaggcccug augagncgaa aagcagc 27

＜210＞ 368<210> 368

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 368<400> 368

gcccacgcug augagncgaa aggccga 27gcccacgcug augagncgaa aggccga 27

＜210＞ 369<210> 369

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 369<400> 369

cgcccaccug augagncgaa aaggccg 27cgcccaccug augagncgaa aaggccg 27

＜210＞ 370<210> 370

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 370<400> 370

caccggccug augagncgaa augccgg 27caccggccug augagncgaa augccgg 27

＜210＞ 371<210> 371

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 371<400> 371

ugcugcccug augagncgaa auggccg 27ugcugcccug augagncgaa auggccg 27

＜210＞ 372<210> 372

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 372<400> 372

caaggcccug augagncgaa augcugc 27caaggcccug augagncgaa augcugc 27

＜210＞ 373<210> 373

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 373<400> 373

ccuuccccug augagncgaa aggccua 27ccuuccccug augagncgaa aggccua 27

＜210＞ 374<210> 374

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 374<400> 374

cgcuccacug augagncgaa agcccgc 27cgcuccacug augagncgaa agcccgc 27

＜210＞ 375<210> 375

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 375<400> 375

aagccaccug augagncgaa agugcac 27aagccaccug augagncgaa agugcac 27

＜210＞ 376<210> 376

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 376<400> 376

accuuaacug augagncgaa agccacg 27accuuaacug augagncgaa agccacg 27

＜210＞ 377<210> 377

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 377<400> 377

gaccuuacug augagncgaa aagccac 27gaccuuacug augagncgaa aagccac 27

＜210＞ 378<210> 378

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 378<400> 378

ugaccuucug augagncgaa aaagcca 27ugaccuucug augagncgaa aaagcca 27

＜210＞ 379<210> 379

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 379<400> 379

augaccucug augagncgaa aaaagcc 27augaccucug augagncgaa aaaagcc 27

＜210＞ 380<210> 380

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 380<400> 380

cgcucaucug augagncgaa accuuaa 27cgcucaucug augagncgaa accuuaa 27

＜210＞ 381<210> 381

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 381<400> 381

cucggcgcug augagncgaa agggcgc 27cucggcgcug augagncgaa agggcgc 27

＜210＞ 382<210> 382

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 382<400> 382

gcaaguucug augagncgaa accaggu 27gcaaguucug augagncgaa accaggu 27

＜210＞ 383<210> 383

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 383<400> 383

agcaagucug augagncgaa aaccagg 27agcaagucug augagncgaa aaccagg 27

＜210＞ 384<210> 384

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 384<400> 384

uggcaggcug augagncgaa agcaagu 27uggcaggcug augagncgaa agcaagu 27

＜210＞ 385<210> 385

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 385<400> 385

gccggggcug augagncgaa agaggau 27gccggggcug augagncgaa agaggau 27

＜210＞ 386<210> 386

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 386<400> 386

ccccgaccug augagncgaa accaggg 27ccccgaccug augagncgaa accaggg 27

＜210＞ 387<210> 387

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 387<400> 387

cgacccccug augagncgaa acgacca 27cgacccccug augagncgaa acgacca 27

＜210＞ 388<210> 388

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 388<400> 388

cacacaccug augagncgaa accccga 27cacacaccug augagncgaa accccga 27

＜210＞ 389<210> 389

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 389<400> 389

gacgcagcug augagncgaa auugcug 27gacgcagcug augagncgaa auugcug 27

＜210＞ 390<210> 390

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 390<400> 390

acgugcccug augagncgaa acgcagg 27acgugcccug augagncgaa acgcagg 27

＜210＞ 391<210> 391

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 391<400> 391

cgaagcgcug augagncgaa acgcuau 27cgaagcgcug augagncgaa acgcuau 27

＜210＞ 392<210> 392

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 392<400> 392

gcgaagccug augagncgaa aacgcua 27gcgaagccug augagncgaa aacgcua 27

＜210＞ 393<210> 393

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 393<400> 393

ccccgcgcug augagncgaa agcgaac 27ccccgcgcug augagncgaa agcgaac 27

＜210＞ 394<210> 394

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 394<400> 394

uuugcaucug augagncgaa augccgu 27uuugcaucug augagncgaa augccgu 27

＜210＞ 395<210> 395

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 395<400> 395

ccuggaacug augagncgaa aguucgg 27ccuggaacug augagncgaa aguucgg 27

＜210＞ 396<210> 396

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 396<400> 396

gcccuggcug augagncgaa auaguuc 27gcccuggcug augagncgaa auaguuc 27

＜210＞ 397<210> 397

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 397<400> 397

cgcccugcug augagncgaa aauaguu 27cgcccugcug augagncgaa aauaguu 27

＜210＞ 398<210> 398

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 398<400> 398

guaguggcug augagncgaa agucccc 27guaguggcug augagncgaa agucccc 27

＜210＞ 399<210> 399

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 399<400> 399

cguagugcug augagncgaa aaguccc 27cguagugcug augagncgaa aaguccc 27

＜210＞ 400<210> 400

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 400<400> 400

cgucacgcug augagncgaa aguggaa 27cgucacgcug augagncgaa aguggaa 27

＜210＞ 401<210> 401

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 401<400> 401

ggcauuucug augagncgaa acguugu 27ggcauuucug augagncgaa acguugu 27

＜210＞ 402<210> 402

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 402<400> 402

ggugaagcug augagncgaa auucggg 27ggugaagcug augagncgaa auucggg 27

＜210＞ 403<210> 403

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 403<400> 403

cggugaacug augagncgaa aauucgg 27cggugaacug augagncgaa aauucgg 27

＜210＞ 404<210> 404

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 404<400> 404

uucggugcug augagncgaa agaauuc 27uucggugcug augagncgaa agaauuc 27

＜210＞ 405<210> 405

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 405<400> 405

auucggucug augagncgaa aagaauu 27auucggucug augagncgaa aagaauu 27

＜210＞ 406<210> 406

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 406<400> 406

cccgucccug augagncgaa auucggu 27cccgucccug augagncgaa auucggu 27

＜210＞ 407<210> 407

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 407<400> 407

ccugugccug augagncgaa accgcac 27ccugugccug augagncgaa accgcac 27

＜210＞ 408<210> 408

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 408<400> 408

cggagcgcug augagncgaa accugug 27cggagcgcug augagncgaa accugug 27

＜210＞ 409<210> 409

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 409<400> 409

cacgccgcug augagncgaa agcguac 27cacgccgcug augagncgaa agcguac 27

＜210＞ 410<210> 410

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 410<400> 410

cguaggacug augagncgaa aggucug 27cguaggacug augagncgaa aggucug 27

＜210＞ 411<210> 411

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 411<400> 411

cccguagcug augagncgaa agagguc 27cccguagcug augagncgaa agagguc 27

＜210＞ 412<210> 412

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 412<400> 412

ccucccgcug augagncgaa aggagag 27ccucccgcug augagncgaa aggagag 27

＜210＞ 413<210> 413

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 413<400> 413

ggaaugucug augagncgaa acauccu 27ggaaugucug augagncgaa acauccu 27

＜210＞ 414<210> 414

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 414<400> 414

cgaccugcug augagncgaa aauguga 27cgaccugcug augagncgaa aauguga 27

＜210＞ 415<210> 415

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 415<400> 415

ugagccccug augagncgaa accugga 27ugagccccug augagncgaa accugga 27

＜210＞ 416<210> 416

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 416<400> 416

auugguucug augagncgaa agcccga 27auugguucug augagncgaa agcccga 27

＜210＞ 417<210> 417

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 417<400> 417

aaccaggcug augagncgaa auugguu 27aaccaggcug augagncgaa auugguu 27

＜210＞ 418<210> 418

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 418<400> 418

gugaccccug augagncgaa accaggu 27gugaccccug augagncgaa accaggu 27

＜210＞ 419<210> 419

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 419<400> 419

gagcugucug augagncgaa acccaac 27gagcugucug augagncgaa acccaac 27

＜210＞ 420<210> 420

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 420<400> 420

cgcauggcug augagncgaa agcugug 27cgcauggcug augagncgaa agcugug 27

＜210＞ 421<210> 421

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 421<400> 421

gccagcccug augagncgaa acguuua 27gccagcccug augagncgaa acguuua 27

＜210＞ 422<210> 422

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 422<400> 422

ggggggacug augagncgaa acccccu 27ggggggacug augagncgaa acccccu 27

＜210＞ 423<210> 423

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 423<400> 423

gagggggcug augagncgaa agacccc 27gagggggcug augagncgaa agacccc 27

＜210＞ 424<210> 424

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 424<400> 424

ggccaagcug augagncgaa agggggg 27ggccaagcug augagncgaa agggggg 27

＜210＞ 425<210> 425

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 425<400> 425

gcuggcccug augagncgaa aggaggg 27gcuggcccug augagncgaa aggaggg 27

＜210＞ 426<210> 426

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 426<400> 426

agcugaacug augagncgaa agcuggc 27agcugaacug augagncgaa agcuggc 27

＜210＞ 427<210> 427

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 427<400> 427

cgcagaccug augagncgaa auuggcu 27cgcagaccug augagncgaa auuggcu 27

＜210＞ 428<210> 428

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 428<400> 428

aggcgcacug augagncgaa acaauug 27aggcgcacug augagncgaa acaauug 27

＜210＞ 429<210> 429

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 429<400> 429

gccacagcug augagncgaa agguugg 27gccacagcug augagncgaa agguugg 27

＜210＞ 430<210> 430

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 430<400> 430

ccgcucgcug augagncgaa agcgggu 27ccgcucgcug augagncgaa agcgggu 27

＜210＞ 431<210> 431

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 431<400> 431

uccgcuccug augagncgaa aagcggg 27uccgcuccug augagncgaa aagcggg 27

＜210＞ 432<210> 432

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 432<400> 432

caacggacug augagncgaa acuuccc 27caacggacug augagncgaa acuuccc 27

＜210＞ 433<210> 433

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 433<400> 433

uaugggccug augagncgaa acgcggg 27uaugggccug augagncgaa acgcggg 27

＜210＞ 434<210> 434

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 434<400> 434

gugcccacug augagncgaa augggca 27gugcccacug augagncgaa augggca 27

＜210＞ 435<210> 435

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 435<400> 435

ggguugucug augagncgaa auccggg 27ggguugucug augagncgaa auccggg 27

＜210＞ 436<210> 436

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 436<400> 436

aggguugcug augagncgaa aauccgg 27aggguugcug augagncgaa aauccgg 27

＜210＞ 437<210> 437

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 437<400> 437

ggacucucug augagncgaa acagugg 27ggacucucug augagncgaa acagugg 27

＜210＞ 438<210> 438

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 438<400> 438

aggacuccug augagncgaa aacagug 27aggacuccug augagncgaa aacagug 27

＜210＞ 439<210> 439

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 439<400> 439

uaguccgcug augagncgaa acuuuuc 27uaguccgcug augagncgaa acuuuuc 27

＜210＞ 440<210> 440

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 440<400> 440

agggacgcug augagncgaa aguccgg 27agggacgcug augagncgaa aguccgg 27

＜210＞ 441 ＜211＞ 27<210> 441 <211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 441<400> 441

ccggaggcug augagncgaa acguagu 27ccggaggcug augagncgaa acguagu 27

＜210＞ 442<210> 442

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 442<400> 442

accgccgcug augagncgaa agggacg 27accgccgcug augagncgaa agggacg 27

＜210＞ 443<210> 443

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 443<400> 443

aggcggccug augagncgaa augggca 27aggcggccug augagncgaa augggca 27

＜210＞ 444<210> 444

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 444<400> 444

cccguggcug augagncgaa aggcggc 27cccguggcug augagncgaa aggcggc 27

＜210＞ 445<210> 445

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 445<400> 445

cacggugcug augagncgaa acucugu 27cacggugcug augagncgaa acucugu 27

＜210＞ 446<210> 446

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 446<400> 446

gucuuagcug augagncgaa agccagc 27gucuuagcug augagncgaa agccagc 27

＜210＞ 447<210> 447

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 447<400> 447

aaagucucug augagncgaa aguagcc 27aaagucucug augagncgaa aguagcc 27

＜210＞ 448<210> 448

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 448<400> 448

cugccgacug augagncgaa agucuua 27cugccgacug augagncgaa agucuua 27

＜210＞ 449<210> 449

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 449<400> 449

gcugccgcug augagncgaa aagucuu 27gcugccgcug augagncgaa aagucuu 27

＜210＞ 450<210> 450

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 450<400> 450

agcugcccug augagncgaa aaagucu 27agcugcccug augagncgaa aaagucu 27

＜210＞ 451<210> 451

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 451<400> 451

ggccgaccug augagncgaa auccgga 27ggccgaccug augagncgaa auccgga 27

＜210＞ 452<210> 452

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 452<400> 452

aacggcccug augagncgaa acgaucc 27aacggcccug augagncgaa acgaucc 27

＜210＞ 453<210> 453

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 453<400> 453

cgcuguccug augagncgaa acggccg 27cgcuguccug augagncgaa acggccg 27

＜210＞ 454<210> 454

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 454<400> 454

cauggagcug augagncgaa aguacga 27cauggagcug augagncgaa aguacga 27

＜210＞ 455<210> 455

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 455<400> 455

gggcaugcug augagncgaa aggagua 27gggcaugcug augagncgaa aggagua 27

＜210＞ 456<210> 456

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 456<400> 456

cccccuccug augagncgaa agggggg 27cccccuccug augagncgaa agggggg 27

＜210＞ 457<210> 457

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 457<400> 457

ucgcugacug augagncgaa aucaggg 27ucgcugacug augagncgaa aucaggg 27

＜210＞ 458<210> 458

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 458<400> 458

cgucgcucug augagncgaa agaucag 27cgucgcucug augagncgaa agaucag 27

＜210＞ 459<210> 459

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 459<400> 459

agaccaacug augagncgaa acccguc 27agaccaacug augagncgaa acccguc 27

＜210＞ 460<210> 460

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 460<400> 460

guagacccug augagncgaa agacccg 27guagacccug augagncgaa agacccg 27

＜210＞ 461<210> 461

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 461<400> 461

cacgguacug augagncgaa accaaga 27cacgguacug augagncgaa accaaga 27

＜210＞ 462<210> 462

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 462<400> 462

cucacggcug augagncgaa agaccaa 27cucacggcug augagncgaa agaccaa 27

＜210＞ 463<210> 463

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 463<400> 463

agcagaccug augagncgaa augucgu 27agcagaccug augagncgaa augucgu 27

＜210＞ 464<210> 464

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 464<400> 464

agcagcacug augagncgaa acgaugu 27agcagcacug augagncgaa acgaugu 27

＜210＞ 465<210> 465

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 465<400> 465

ggacauucug augagncgaa agcagca 27ggacauucug augagncgaa agcagca 27

＜210＞ 466<210> 466

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 466<400> 466

uguguagcug augagncgaa acauuga 27uguguagcug augagncgaa acauuga 27

＜210＞ 467<210> 467

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 467<400> 467

acgcguucug augagncgaa augggca 27acgcguucug augagncgaa augggca 27

＜210＞ 468<210> 468

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 468<400> 468

acugcggcug augagncgaa auguugu 27acugcggcug augagncgaa auguugu 27

＜210＞ 469<210> 469

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 469<400> 469

cguccagcug augagncgaa acuugca 27cguccagcug augagncgaa acuugca 27

＜210＞ 470<210> 470

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 470<400> 470

gucccggcug augagncgaa agugguc 27gucccggcug augagncgaa agugguc 27

＜210＞ 471<210> 471

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 471<400> 471

agaaguucug augagncgaa agccuua 27agaaguucug augagncgaa agccuua 27

＜210＞ 472<210> 472

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 472<400> 472

cuacggacug augagncgaa agaaguu 27cuacggacug augagncgaa agaaguu 27

＜210＞ 473<210> 473

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 473<400> 473

uucuacgcug augagncgaa auagaag 27uucuacgcug augagncgaa auagaag 27

＜210＞ 474<210> 474

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 474<400> 474

cuucuuccug augagncgaa acggaua 27cuucuuccug augagncgaa acggaua 27

＜210＞ 475<210> 475

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 475<400> 475

aaauuuacug augagncgaa auuuggc 27aaauuuacug augagncgaa auuuggc 27

＜210＞ 476<210> 476

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 476<400> 476

ccaaauucug augagncgaa agauuug 27ccaaauucug augagncgaa agauuug 27

＜210＞ 477<210> 477

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 477<400> 477

auagccacug augagncgaa auuuaga 27auagccacug augagncgaa auuuaga 27

＜210＞ 478<210> 478

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 478<400> 478

cauagcccug augagncgaa aauuuag 27cauagcccug augagncgaa aauuuag 27

＜210＞ 479<210> 479

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 479<400> 479

ugccccacug augagncgaa agccaaa 27ugccccacug augagncgaa agccaaa 27

＜210＞ 480<210> 480

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 480<400> 480

cggagcgcug augagncgaa auguggu 27cggagcgcug augagncgaa auguggu 27

＜210＞ 481<210> 481

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 481<400> 481

ccacacgcug augagncgaa agcggau 27ccacacgcug augagncgaa agcggau 27

＜210＞ 482<210> 482

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 482<400> 482

auacgaucug augagncgaa aggcgag 27auacgaucug augagncgaa aggcgag 27

＜210＞ 483<210> 483

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 483<400> 483

aauacgacug augagncgaa aaggcga 27aauacgacug augagncgaa aaggcga 27

＜210＞ 484<210> 484

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 484<400> 484

ggaauaccug augagncgaa auaaggc 27ggaauaccug augagncgaa auaaggc 27

＜210＞ 485<210> 485

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 485<400> 485

gaauccgcug augagncgaa acgagga 27gaauccgcug augagncgaa acgagga 27

＜210＞ 486<210> 486

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 486<400> 486

guacuggcug augagncgaa auccgua 27guacuggcug augagncgaa auccgua 27

＜210＞ 487<210> 487

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 487<400> 487

aggagagcug augagncgaa acuggaa 27aggagagcug augagncgaa acuggaa 27

＜210＞ 488<210> 488

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 488<400> 488

ugcccagcug augagncgaa agaguac 27ugcccagcug augagncgaa agaguac 27

＜210＞ 489<210> 489

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 489<400> 489

ggaacuccug augagncgaa acccgcu 27ggaacuccug augagncgaa acccgcu 27

＜210＞ 490<210> 490

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 490<400> 490

caccaggcug augagncgaa acucaac 27caccaggcug augagncgaa acucaac 27

＜210＞ 491<210> 491

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 491<400> 491

ucaccagcug augagncgaa aacucaa 27ucaccagcug augagncgaa aacucaa 27

＜210＞ 492<210> 492

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 492<400> 492

uuucuuucug augagncgaa auuucca 27uuucuuucug augagncgaa auuucca 27

＜210＞ 493<210> 493

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 493<400> 493

gcgacuucug augagncgaa auggccu 27gcgacuucug augagncgaa auggccu 27

＜210＞ 494<210> 494

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 494<400> 494

cgugagccug augagncgaa acuuuau 27cgugagccug augagncgaa acuuuau 27

＜210＞ 495<210> 495

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 495<400> 495

gcuccgucug augagncgaa agcgacu 27gcuccgucug augagncgaa agcgacu 27

＜210＞ 496<210> 496

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 496<400> 496

cgauguacug augagncgaa agccgcu 27cgauguacug augagncgaa agccgcu 27

＜210＞ 497<210> 497

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 497<400> 497

cccgaugcug augagncgaa agagccg 27cccgaugcug augagncgaa agagccg 27

＜210＞ 498<210> 498

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 498<400> 498

ggccccccug augagncgaa auguaga 27ggccccccug augagncgaa auguaga 27

＜210＞ 499<210> 499

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 499<400> 499

cggcgaucug augagncgaa accgcag 27cggcgaucug augagncgaa accgcag 27

＜210＞ 500<210> 500

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 500<400> 500

ccggcgacug augagncgaa aaccgca 27ccggcgacug augagncgaa aaccgca 27

＜210＞ 501<210> 501

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 501<400> 501

caccggccug augagncgaa auaaccg 27caccggccug augagncgaa auaaccg 27

＜210＞ 502<210> 502

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 502<400> 502

ccgcagccug augagncgaa agucguc 27ccgcagccug augagncgaa agucguc 27

＜210＞ 503<210> 503

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 503<400> 503

gcagcuccug augagncgaa acaggcc 27gcagcuccug augagncgaa acaggcc 27

＜210＞ 504<210> 504

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 504<400> 504

aguccugcug augagncgaa agcuuug 27aguccugcug augagncgaa agcuuug 27

＜210＞ 505<210> 505

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 505<400> 505

cguucaccug augagncgaa agcaucg 27cguucaccug augagncgaa agcaucg 27

＜210＞ 506<210> 506

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 506<400> 506

uaacgaccug augagncgaa aggucgu 27uaacgaccug augagncgaa aggucgu 27

＜210＞ 507<210> 507

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 507<400> 507

agauaaccug augagncgaa acaaggu 27agauaaccug augagncgaa acaaggu 27

＜210＞ 508<210> 508

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 508<400> 508

cacagaucug augagncgaa acgacaa 27cacagaucug augagncgaa acgacaa 27

＜210＞ 509<210> 509

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 509<400> 509

gggggcacug augagncgaa aguaccu 27gggggcacug augagncgaa aguaccu 27

＜210＞ 510<210> 510

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 510<400> 510

caagucgcug augagncgaa auucugg 27caagucgcug augagncgaa auucugg 27

＜210＞ 511<210> 511

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 511<400> 511

guuggagcug augagncgaa agcauga 27guuggagcug augagncgaa agcauga 27

＜210＞ 512<210> 512

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 512<400> 512

cacguugcug augagncgaa aggagca 27cacguugcug augagncgaa aggagca 27

＜210＞ 513<210> 513

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 513<400> 513

uuugccgcug augagncgaa augcguc 27uuugccgcug augagncgaa augcguc 27

＜210＞ 514<210> 514

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 514<400> 514

cccgugccug augagncgaa agggggg 27cccgugccug augagncgaa agggggg 27

＜210＞ 515<210> 515

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 515<400> 515

gggcgcacug augagncgaa acaugau 27gggcgcacug augagncgaa acaugau 27

＜210＞ 516<210> 516

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 516<400> 516

ugcccaucug augagncgaa agguggg 27ugcccaucug augagncgaa agguggg 27

＜210＞ 517<210> 517

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 517<400> 517

uugcccacug augagncgaa aaggugg 27uugcccacug augagncgaa aaggugg 27

＜210＞ 518<210> 518

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 518<400> 518

gucaucacug augagncgaa aaucauc 27gucaucacug augagncgaa aaucauc 27

＜210＞ 519<210> 519

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 519<400> 519

aagaagucug augagncgaa agucauc 27aagaagucug augagncgaa agucauc 27

＜210＞ 520<210> 520

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 520<400> 520

aucugaccug augagncgaa auccagg 27aucugaccug augagncgaa auccagg 27

＜210＞ 521<210> 521

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 521<400> 521

uagaucucug augagncgaa acaaucc 27uagaucucug augagncgaa acaaucc 27

＜210＞ 522<210> 522

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 522<400> 522

ccccguacug augagncgaa aucugac 27ccccguacug augagncgaa aucugac 27

＜210＞ 523<210> 523

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 523<400> 523

ggccccgcug augagncgaa agaucug 27ggccccgcug augagncgaa agaucug 27

＜210＞ 524<210> 524

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 524<400> 524

guuuccucug augagncgaa aggcaug 27guuuccucug augagncgaa aggcaug 27

＜210＞ 525<210> 525

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 525<400> 525

guacccccug augagncgaa aguuucc 27guacccccug augagncgaa aguuucc 27

＜210＞ 526<210> 526

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 526<400> 526

agggcggcug augagncgaa accccaa 27agggcggcug augagncgaa accccaa 27

＜210＞ 527<210> 527

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 527<400> 527

gacucgccug augagncgaa agggcgg 27gacucgccug augagncgaa agggcgg 27

＜210＞ 528<210> 528

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 528<400> 528

gucuccacug augagncgaa acucgca 27gucuccacug augagncgaa acucgca 27

＜210＞ 529<210> 529

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 529<400> 529

uagcgcgcug augagncgaa acacuuc 27uagcgcgcug augagncgaa acacuuc 27

＜210＞ 530<210> 530

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 530<400> 530

aguagcccug augagncgaa agcgcgg 27aguagcccug augagncgaa agcgcgg 27

＜210＞ 531<210> 531

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 531<400> 531

gggacagcug augagncgaa agccuag 27gggacagcug augagncgaa agccuag 27

＜210＞ 532<210> 532

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 532<400> 532

cccuuggcug augagncgaa acaguag 27cccuuggcug augagncgaa acaguag 27

＜210＞ 533<210> 533

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 533<400> 533

cagcuggcug augagncgaa acgcggc 27cagcuggcug augagncgaa acgcggc 27

＜210＞ 534<210> 534

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 534<400> 534

gcuggaccug augagncgaa aguccag 27gcuggaccug augagncgaa aguccag 27

＜210＞ 535<210> 535

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 535<400> 535

ccagcugcug augagncgaa acaaguc 27ccagcugcug augagncgaa acaaguc 27

＜210＞ 536<210> 536

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 536<400> 536

agcaacgcug augagncgaa accagcu 27agcaacgcug augagncgaa accagcu 27

＜210＞ 537<210> 537

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 537<400> 537

cagcaaccug augagncgaa aaccagc 27cagcaaccug augagncgaa aaccagc 27

＜210＞ 538<210> 538

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 538<400> 538

aaccagccug augagncgaa acgaacc 27aaccagccug augagncgaa acgaacc 27

＜210＞ 539<210> 539

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 539<400> 539

ugugauacug augagncgaa augucuc 27ugugauacug augagncgaa augucuc 27

＜210＞ 540<210> 540

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 540<400> 540

gcugugacug augagncgaa auauguc 27gcugugacug augagncgaa auauguc 27

＜210＞ 541<210> 541

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 541<400> 541

aggcugucug augagncgaa auauaug 27aggcugucug augagncgaa auauaug 27

＜210＞ 542<210> 542

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 542<400> 542

ggcacgacug augagncgaa acaggcu 27ggcacgacug augagncgaa acaggcu 27

＜210＞ 543<210> 543

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 543<400> 543

guaggagcug augagncgaa aggcacc 27guaggagcug augagncgaa aggcacc 27

＜210＞ 544<210> 544

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 544<400> 544

aaaguagcug augagncgaa aguaggc 27aaaguagcug augagncgaa aguaggc 27

＜210＞ 545<210> 545

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 545<400> 545

cggaaagcug augagncgaa aggagua 27cggaaagcug augagncgaa aggagua 27

＜210＞ 546<210> 546

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 546<400> 546

cuacggacug augagncgaa aguagga 27cuacggacug augagncgaa aguagga 27

＜210＞ 547<210> 547

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 547<400> 547

ccuacggcug augagncgaa aaguagg 27ccuacggcug augagncgaa aaguagg 27

＜210＞ 548<210> 548

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 548<400> 548

cccuacgcug augagncgaa aaaguag 27cccuacgcug augagncgaa aaaguag 27

＜210＞ 549<210> 549

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 549<400> 549

cuacccccug augagncgaa acggaaa 27cuacccccug augagncgaa acggaaa 27

＜210＞ 550<210> 550

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 550<400> 550

agaugcccug augagncgaa accccua 27agaugcccug augagncgaa accccua 27

＜210＞ 551<210> 551

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 551<400> 551

gcagguacug augagncgaa augccua 27gcagguacug augagncgaa augccua 27

＜210＞ 552<210> 552

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 552<400> 552

gagcaggcug augagncgaa agaugcc 27gagcaggcug augagncgaa agaugcc 27

＜210＞ 553<210> 553

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 553<400> 553

gguugggcug augagncgaa agcaggu 27gguugggcug augagncgaa agcaggu 27

＜210＞ 554<210> 554

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 554<400> 554

gagugaucug augagncgaa agcuccc 27gagugaucug augagncgaa agcuccc 27

＜210＞ 555<210> 555

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 555<400> 555

cuggagucug augagncgaa auuagcu 27cuggagucug augagncgaa auuagcu 27

＜210＞ 556<210> 556

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 556<400> 556

uggccugcug augagncgaa agugauu 27uggccugcug augagncgaa agugauu 27

＜210＞ 557<210> 557

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 557<400> 557

gauggcccug augagncgaa auuggcc 27gauggcccug augagncgaa auuggcc 27

＜210＞ 558<210> 558

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 558<400> 558

cgacacucca ccaua 15cgacacucca ccaua 15

＜210＞ 559<210> 559

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 559<400> 559

gcagccucca ggacc 15gcagccucca ggacc 15

＜210＞ 560<210> 560

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 560<400> 560

ccccccuccc gggag 15ccccccuccc gggag 15

＜210＞ 561<210> 561

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 561<400> 561

uaguggucug cggaa 15uaguggucug cggaa 15

＜210＞ 562<210> 562

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 562<400> 562

ggugaguaca ccgga 15ggugaguaca ccgga 15

＜210＞ 563<210> 563

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 563<400> 563

ccggaauugc cagga 15ccggaauugc cagga 15

＜210＞ 564<210> 564

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 564<400> 564

ccuuucuugg aucaa 15ccuuucuugg aucaa 15

＜210＞ 565<210> 565

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 565<400> 565

acccgcucaa ugccu 15acccgcucaa ugccu 15

＜210＞ 566<210> 566

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 566<400> 566

gacugcuagc cgagu 15gacugcuagc cgagu 15

＜210＞ 567<210> 567

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 567<400> 567

gccgaguagu guugg 15gccgaguagu guugg 15

＜210＞ 568<210> 568

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 568<400> 568

guaguguugg gucgc 15guaguguugg gucgc 15

＜210＞ 569<210> 569

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 569<400> 569

guugggucgc gaaag 15guugggucgc gaaag 15

＜210＞ 570<210> 570

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 570<400> 570

uugugguacu gccug 15uugugguacu gccug 15

＜210＞ 571<210> 571

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 571<400> 571

gccugauagg gugcu 15gccugauagg gugcu 15

＜210＞ 572<210> 572

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 572<400> 572

gggugcuugc gagug 15gggugcuugc gagug 15

＜210＞ 573<210> 573

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 573<400> 573

gggaggucuc guaga 15gggaggucuc guaga 15

＜210＞ 574<210> 574

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 574<400> 574

gaggucucgu agacc 15gaggucucgu agacc 15

＜210＞ 575<210> 575

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 575<400> 575

gucucguaga ccgug 15gucucguaga ccgug 15

＜210＞ 576<210> 576

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 576<400> 576

aggacgucaa guucc 15aggacgucaa guucc 15

＜210＞ 577<210> 577

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 577<400> 577

gucaaguucc cgggc 15gucaaguucc cgggc 15

＜210＞ 578<210> 578

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 578<400> 578

ucaaguuccc gggcg 15ucaaguuccc gggcg 15

＜210＞ 579<210> 579

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 579<400> 579

cgguggucag aucgu 15cgguggucag aucgu 15

＜210＞ 580<210> 580

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 580<400> 580

cccacguugg gugug 15cccacguugg gugug 15

＜210＞ 581<210> 581

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 581<400> 581

cgcgacuagg aagac 15cgcgacuagg aagac 15

＜210＞ 582<210> 582

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 582<400> 582

gaagacuucc gaacg 15gaagacuucc gaacg 15

＜210＞ 583<210> 583

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 583<400> 583

aagacuuccg aacgg 15aagacuuccg aacgg 15

＜210＞ 584<210> 584

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 584<400> 584

gaacggucgc aaccu 15gaacggucgc aaccu 15

＜210＞ 585<210> 585

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 585<400> 585

acaaccuauc cccaa 15acaaccuauc cccaa 15

＜210＞ 586<210> 586

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 586<400> 586

aaccuauccc caagg 15aaccuauccc caagg 15

＜210＞ 587<210> 587

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 587<400> 587

caaggcucgc cgacc 15caaggcucgc cgacc 15

＜210＞ 588<210> 588

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 588<400> 588

cgaggguagg gccug 15cgaggguagg gccug 15

＜210＞ 589<210> 589

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 589<400> 589

cugggcucag ccugg 15cugggcucag ccugg 15

＜210＞ 590<210> 590

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 590<400> 590

ccuggguacc cuugg 15ccuggguacc cuugg 15

＜210＞ 591<210> 591

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 591<400> 591

guacccuugg ccccu 15guacccuugg ccccu 15

＜210＞ 592<210> 592

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 592<400> 592

ggccccucua uggca 15ggccccucua uggca 15

＜210＞ 593<210> 593

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 593<400> 593

ccccucuaug gcaau 15ccccucuaug gcaau 15

＜210＞ 594<210> 594

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 594<400> 594

gauggcuccu gucac 15gauggcuccu gucac 15

＜210＞ 595<210> 595

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 595<400> 595

cuccugucac cccgc 15cuccugucac cccgc 15

＜210＞ 596<210> 596

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 596<400> 596

cgcggcuccc ggccu 15cgcggcuccc ggccu 15

＜210＞ 597<210> 597

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 597<400> 597

ccggccuagu ugggg 15ccggccuagu ugggg 15

＜210＞ 598<210> 598

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 598<400> 598

gccuaguugg ggccc 15gccuaguugg ggccc 15

＜210＞ 599<210> 599

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 599<400> 599

gcgcaaucug gguaa 15gcgcaaucug gguaa 15

＜210＞ 600<210> 600

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 600<400> 600

guaaggucau cgaua 15guaaggucau cgaua 15

＜210＞ 601<210> 601

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 601<400> 601

aggucaucga uaccc 15aggucaucga uaccc 15

＜210＞ 602<210> 602

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 602<400> 602

caucgauacc cucac 15caucgauacc cucac 15

＜210＞ 603<210> 603

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 603<400> 603

ugcggcuucg ccgac 15ugcggcuucg ccgac 15

＜210＞ 604<210> 604

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 604<400> 604

gcggcuucgc cgacc 15gcggcuucgc cgacc 15

＜210＞ 605<210> 605

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 605<400> 605

augggguaca uuccg 15augggguaca uuccg 15

＜210＞ 606<210> 606

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 606<400> 606

gguacauucc gcucg 15gguacauucc gcucg 15

＜210＞ 607<210> 607

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 607<400> 607

guacauuccg cucgu 15guacauuccg cucgu 15

＜210＞ 608<210> 608

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 608<400> 608

uuccgcucgu cggcg 15uuccgcucgu cggcg 15

＜210＞ 609<210> 609

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 609<400> 609

cgcucgucgg cgccc 15cgcucgucgg cgccc 15

＜210＞ 610<210> 610

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 610<400> 610

ccccccuagg gggcg 15ccccccuagg gggcg 15

＜210＞ 611<210> 611

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 611<400> 611

augguguccg gguuc 15augguguccg gguuc 15

＜210＞ 612<210> 612

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 612<400> 612

uccggguucu ggagg 15uccggguucu ggagg 15

＜210＞ 613<210> 613

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 613<400> 613

ccggguucug gagga 15ccggguucug gagga 15

＜210＞ 614<210> 614

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 614<400> 614

gugaacuacg caaca 15gugaacuacg caaca 15

＜210＞ 615<210> 615

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 615<400> 615

gggaacuugc ccggu 15gggaacuugc ccggu 15

＜210＞ 616<210> 616

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 616<400> 616

gcccgguugc ucuuu 15gcccgguugc ucuuu 15

＜210＞ 617<210> 617

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 617<400> 617

gguugcucuu ucucu 15gguugcucuu ucucu 15

＜210＞ 618<210> 618

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 618<400> 618

auuguguaug aggca 15auuguguaug aggca 15

＜210＞ 619<210> 619

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 619<400> 619

gcaugaucau gcaua 15gcaugaucau gcaua 15

＜210＞ 620<210> 620

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 620<400> 620

ggugcguacc cugcg 15ggugcguacc cugcg 15

＜210＞ 621<210> 621

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 621<400> 621

ccugcguucg ggaga 15ccugcguucg ggaga 15

＜210＞ 622<210> 622

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 622<400> 622

cugcguucgg gagaa15cugcguucgg gagaa15

＜210＞ 623<210> 623

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 623<400> 623

aacgccuccc guugu 15aacgccuccc guugu 15

＜210＞ 624<210> 624

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 624<400> 624

cucccguugu ugggu 15cucccguugu ugggu 15

＜210＞ 625<210> 625

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 625<400> 625

ccguuguugg guagc 15ccguuguugg guagc 15

＜210＞ 626<210> 626

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 626<400> 626

guuggguagc gcuca 15guuggguagc gcuca 15

＜210＞ 627<210> 627

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 627<400> 627

gccacgucga cuugc 15gccacgucga cuugc 15

＜210＞ 628<210> 628

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 628<400> 628

gucgacuugc ucguu 15gucgacuugc ucguu 15

＜210＞ 629<210> 629

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 629<400> 629

acuugcucgu ugggg 15acuugcucgu ugggg 15

＜210＞ 630<210> 630

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 630<400> 630

ugcucguugg ggcgg 15ugcucguugg ggcgg 15

＜210＞ 631<210> 631

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 631<400> 631

gccgcuuucu guucc 15gccgcuuucu guucc 15

＜210＞ 632<210> 632

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 632<400> 632

ccgcuuucug uuccg 15ccgcuuucug uuccg 15

＜210＞ 633<210> 633

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 633<400> 633

uuucuguucc gccau 15uuucuguucc gccau 15

＜210＞ 634<210> 634

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 634<400> 634

uucuguuccg ccaug 15uucuguuccg ccaug 15

＜210＞ 635<210> 635

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 635<400> 635

gccauguacg ugggg 15gccauguacg ugggg 15

＜210＞ 636<210> 636

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 636<400> 636

ugcggauccg uuuuc 15ugcggauccg uuuuc 15

＜210＞ 637<210> 637

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 637<400> 637

gauccguuuu ccucg 15gauccguuuu ccucg 15

＜210＞ 638<210> 638

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 638<400> 638

auccguuuuc cucgu 15auccguuuuc cucgu 15

＜210＞ 639<210> 639

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 639<400> 639

uccguuuucc ucguc 15uccguuuucc ucguc 15

＜210＞ 640<210> 640

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 640<400> 640

ccguuuuccu cgucu 15ccguuuuccu cgucu 15

＜210＞ 641<210> 641

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 641<400> 641

gccauguauc agguc 15gccauguauc agguc 15

＜210＞ 642<210> 642

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 642<400> 642

cauguaucag gucac 15cauguaucag gucac 15

＜210＞ 643<210> 643

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 643<400> 643

aucaggucac cgcau 15aucaggucac cgcau 15

＜210＞ 644<210> 644

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 644<400> 644

aagcugucgu ggaua 15aagcugucgu ggaua 15

＜210＞ 645<210> 645

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 645<400> 645

cguggauaug guggc 15cguggauaug guggc 15

＜210＞ 646<210> 646

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 646<400> 646

ggggaguccu agcgg 15ggggaguccu agcgg 15

＜210＞ 647<210> 647

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 647<400> 647

gaguccuagc gggcc 15gaguccuagc gggcc 15

＜210＞ 648<210> 648

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 648<400> 648

cgggccuugc cuacu 15cgggccuugc cuacu 15

＜210＞ 649<210> 649

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 649<400> 649

cuugccuacu auucc 15cuugccuacu auucc 15

＜210＞ 650<210> 650

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 650<400> 650

gccuacuauu ccaug 15gccuacuauu ccaug 15

＜210＞ 651<210> 651

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 651<400> 651

cuacuauucc auggu 15cuacuauucc auggu 15

＜210＞ 652<210> 652

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 652<400> 652

uacuauucca uggug 15uacuauucca uggug 15

＜210＞ 653<210> 653

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 653<400> 653

gcuccaucga caagu 15gcuccaucga caagu 15

＜210＞ 654<210> 654

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 654<400> 654

gacaaguucg cucag 15gacaaguucg cucag 15

＜210＞ 655<210> 655

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 655<400> 655

acaaguucgc ucagg 15acaaguucgc ucagg 15

＜210＞ 656<210> 656

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 656<400> 656

guucgcucag ggaug 15guucgcucag ggaug 15

＜210＞ 657<210> 657

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 657<400> 657

gccccaucac cuaua 15gccccaucac cuaua 15

＜210＞ 658<210> 658

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 658<400> 658

aucaccuaua ccgag 15aucaccuaua ccgag 15

＜210＞ 659<210> 659

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 659<400> 659

aggccuuacu gcugg 15aggccuuacu gcugg 15

＜210＞ 660<210> 660

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 660<400> 660

cuggcauuac gcacc 15cuggcauuac gcacc 15

＜210＞ 661<210> 661

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 661<400> 661

uggcauuacg caccu 15uggcauuacg caccu 15

＜210＞ 662<210> 662

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 662<400> 662

cgcaccucgg cagug 15cgcaccucgg cagug 15

＜210＞ 663<210> 663

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 663<400> 663

gugugguauc guacc 15gugugguauc guacc 15

＜210＞ 664<210> 664

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 664<400> 664

gugguaucgu accug 15gugguaucgu accug 15

＜210＞ 665<210> 665

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 665<400> 665

guaucguacc ugcgu 15guaucguacc ugcgu 15

＜210＞ 666<210> 666

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 666<400> 666

ccugcgucgc aggug 15ccugcgucgc aggug 15

＜210＞ 667<210> 667

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 667<400> 667

guguggucca gugua 15guguggucca gugua 15

＜210＞ 668<210> 668

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 668<400> 668

gcccuguugu agugg 15gcccuguugu agugg 15

＜210＞ 669<210> 669

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 669<400> 669

cuguuguagu gggga 15cuguuguagu gggga 15

＜210＞ 670<210> 670

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 670<400> 670

gaccgaucgg uccgg 15gaccgaucgg uccgg 15

＜210＞ 671<210> 671

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 671<400> 671

gaucgguccg gugcc 15gaucgguccg gugcc 15

＜210＞ 672<210> 672

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 672<400> 672

ugccccuacg uauaa 15ugccccuacg uauaa 15

＜210＞ 673<210> 673

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 673<400> 673

ccuacguaua acugg 15ccuacguaua acugg 15

＜210＞ 674<210> 674

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 674<400> 674

uacguauaac ugggg 15uacguauaac ugggg 15

＜210＞ 675<210> 675

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 675<400> 675

aacugguuug gcugu 15aacugguuug gcugu 15

＜210＞ 676<210> 676

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 676<400> 676

acugguuugg cugua 15acugguuugg cugua 15

＜210＞ 677<210> 677

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 677<400> 677

uggcuguaca uggau 15uggcuguaca uggau 15

＜210＞ 678<210> 678

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 678<400> 678

gggcccuccg ugcaa 15gggcccuccg ugcaa 15

＜210＞ 679<210> 679

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 679<400> 679

gcaacaucgg ggggg 15gcaacaucgg ggggg 15

＜210＞ 680<210> 680

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 680<400> 680

ggggggucgg caacc 15ggggggucgg caacc 15

＜210＞ 681<210> 681

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 681<400> 681

gcaaccucac cuuga 15gcaaccucac cuuga 15

＜210＞ 682<210> 682

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 682<400> 682

cucaccuuga ccugc 15cucaccuuga ccugc 15

＜210＞ 683<210> 683

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 683<400> 683

ggccacuuac acaaa 15ggccacuuac acaaa 15

＜210＞ 684<210> 684

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 684<400> 684

gccacuuaca caaaa 15gccacuuaca caaaa 15

＜210＞ 685<210> 685

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 685<400> 685

uguggcucgg ggcca 15uguggcucgg ggcca 15

＜210＞ 686<210> 686

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 686<400> 686

ccaugguuaa caccu 15ccaugguuaa caccu 15

＜210＞ 687<210> 687

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 687<400> 687

caugguuaac accua 15caugguuaac accua 15

＜210＞ 688<210> 688

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 688<400> 688

uuaccaucuu uaagg 15uuaccaucuu uaagg 15

＜210＞ 689<210> 689

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 689<400> 689

accaucuuua agguu 15accaucuuua agguu 15

＜210＞ 690<210> 690

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 690<400> 690

acaggcuuag ugcug 15acaggcuuag ugcug 15

＜210＞ 691<210> 691

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 691<400> 691

caggcuuagu gcugc 15caggcuuagu gcugc 15

＜210＞ 692<210> 692

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 692<400> 692

agagcguugc gaccu 15agagcguugc gaccu 15

＜210＞ 693<210> 693

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 693<400> 693

gacagaucgg agcuc 15gacagaucgg agcuc 15

＜210＞ 694<210> 694

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 694<400> 694

cggagcucag cccgc 15cggagcucag cccgc 15

＜210＞ 695<210> 695

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 695<400> 695

cugcugucca cgaca 15cugcugucca cgaca 15

＜210＞ 696<210> 696

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 696<400> 696

uccaccucca ucaga 15uccaccucca ucaga 15

＜210＞ 697<210> 697

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 697<400> 697

ccuccaucag aacau 15ccuccaucag aacau 15

＜210＞ 698<210> 698

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 698<400> 698

agaacaucgu ggacg 15agaacaucgu ggacg 15

＜210＞ 699<210> 699

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 699<400> 699

cgcgcgucug ugccu 15cgcgcgucug ugccu 15

＜210＞ 700<210> 700

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 700<400> 700

ccgcccuaga gaacc 15ccgcccuaga gaacc 15

＜210＞ 701<210> 701

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 701<400> 701

uggugguccu caacg 15uggugguccu caacg 15

＜210＞ 702<210> 702

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 702<400> 702

ugguccucaa cgcgg 15ugguccucaa cgcgg 15

＜210＞ 703<210> 703

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 703<400> 703

gccugguaca ucaag 15gccugguaca ucaag 15

＜210＞ 704<210> 704

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 704<400> 704

gguacaucaa gggca 15gguacaucaa gggca 15

＜210＞ 705<210> 705

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 705<400> 705

ggcugguccc ugggg 15ggcugguccc ugggg 15

＜210＞ 706<210> 706

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 706<400> 706

gcggcauaug cucug 15gcggcauaug cucug 15

＜210＞ 707<210> 707

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 707<400> 707

auaugcucug uacgg 15auaugcucug uacgg 15

＜210＞ 708<210> 708

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 708<400> 708

gcucuguacg gcgug 15gcucuguacg gcgug 15

＜210＞ 709<210> 709

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 709<400> 709

uccugcuccu gcugg 15uccugcuccu gcugg 15

＜210＞ 710<210> 710

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 710<400> 710

acgggcuuac gccau 15acgggcuuac gccau 15

＜210＞ 711<210> 711

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 711<400> 711

cgggcuuacg ccaug 15cgggcuuacg ccaug 15

＜210＞ 712<210> 712

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 712<400> 712

uggugguuac aauac 15uggugguuac aauac 15

＜210＞ 713<210> 713

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 713<400> 713

ggugguuaca auacu 15ggugguuaca auacu 15

＜210＞ 714<210> 714

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 714<400> 714

uuacaauacu uuauc 15uuacaauacu uuauc 15

＜210＞ 715<210> 715

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 715<400> 715

caauacuuua ucacc 15caauacuuua ucacc 15

＜210＞ 716<210> 716

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 716<400> 716

aauacuuuau cacca 15aauacuuuau cacca 15

＜210＞ 717<210> 717

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 717<400> 717

ggcgcauuug ugcgu 15ggcgcauuug ugcgu 15

＜210＞ 718<210> 718

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 718<400> 718

gcgcauuugu gcgug 15gcgcauuugu gcgug 15

＜210＞ 719<210> 719

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 719<400> 719

uguggguccc cccuc 15uguggguccc cccuc 15

＜210＞ 720<210> 720

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 720<400> 720

ccccccucuc aaugu 15ccccccucuc aaugu 15

＜210＞ 721<210> 721

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 721<400> 721

ccccucucaa ugucc 15ccccucucaa ugucc 15

＜210＞ 722<210> 722

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 722<400> 722

ucaauguccg ggggg 15ucaauguccg ggggg 15

＜210＞ 723<210> 723

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 723<400> 723

cgaugcuauc auccu 15cgaugcuauc auccu 15

＜210＞ 724<210> 724

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 724<400> 724

augcuaucau ccucc 15augcuaucau ccucc 15

＜210＞ 725<210> 725

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 725<400> 725

cuaucauccu ccuca 15cuaucauccu ccuca 15

＜210＞ 726<210> 726

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 726<400> 726

ucauccuccu cacau 15ucauccuccu cacau 15

＜210＞ 727<210> 727

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 727<400> 727

uccuccucac augug 15uccuccucac augug 15

＜210＞ 728<210> 728

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 728<400> 728

cugccauaac ugcga 15cugccauaac ugcga 15

＜210＞ 729<210> 729

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 729<400> 729

aggccauuac gucca 15aggccauuac gucca 15

＜210＞ 730<210> 730

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 730<400> 730

ggccauuacg uccaa 15ggccauuacg uccaa 15

＜210＞ 731<210> 731

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 731<400> 731

auuacgucca aaugg 15auuacgucca aaugg 15

＜210＞ 732<210> 732

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 732<400> 732

auggccuuca ugaag 15auggccuuca ugaag 15

＜210＞ 733<210> 733

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 733<400> 733

uggccuucau gaagc 15uggccuucau gaagc 15

＜210＞ 734<210> 734

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 734<400> 734

ccccgcuaca ggauu 15ccccgcuaca ggauu 15

＜210＞ 735<210> 735

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 735<400> 735

acaggauugg gccca 15acaggauugg gccca 15

＜210＞ 736<210> 736

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 736<400> 736

cgggccuacg agacc 15cgggccuacg agacc 15

＜210＞ 737<210> 737

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 737<400> 737

gagaccuugc ggugg 15gagaccuugc ggugg 15

＜210＞ 738<210> 738

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 738<400> 738

agcccgucgu cuucu 15agcccgucgu cuucu 15

＜210＞ 739<210> 739

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 739<400> 739

ccgucgucuu cucug 15ccgucgucuu cucug 15

＜210＞ 740<210> 740

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 740<400> 740

gucgucuucu cugac 15gucgucuucu cugac 15

＜210＞ 741<210> 741

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 741<400> 741

ccaagaucau caccu 15ccaagaucau caccu 15

＜210＞ 742<210> 742

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 742<400> 742

agaucaucac cuggg 15agaucaucac cuggg 15

＜210＞ 743<210> 743

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 743<400> 743

gggacaucau cuugg 15gggacaucau cuugg 15

＜210＞ 744<210> 744

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 744<400> 744

acaucaucuu gggac 15acaucaucuu gggac 15

＜210＞ 745<210> 745

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 745<400> 745

aucaucuugg gacug 15aucaucuugg gacug 15

＜210＞ 746<210> 746

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 746<400> 746

ugcccgucuc cgccc 15ugcccgucuc cgccc 15

＜210＞ 747<210> 747

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 747<400> 747

cccgucuccg cccga 15cccgucuccg cccga 15

＜210＞ 748<210> 748

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 748<400> 748

gggagauacu ucugg 15gggagauacu ucugg 15

＜210＞ 749<210> 749

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 749<400> 749

ggcgacuccu ugccc 15ggcgacuccu ugccc 15

＜210＞ 750<210> 750

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 750<400> 750

gacuccuugc cccca 15gacuccuugc cccca 15

＜210＞ 751<210> 751

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 751<400> 751

cccccaucac ggccu 15cccccaucac ggccu 15

＜210＞ 752<210> 752

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 752<400> 752

cuagccucac aggcc 15cuagccucac aggcc 15

＜210＞ 753<210> 753

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 753<400> 753

gggagguuca agugg 15gggagguuca agugg 15

＜210＞ 754<210> 754

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 754<400> 754

ggagguucaa guggu 15ggagguucaa guggu 15

＜210＞ 755<210> 755

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 755<400> 755

aagugguuuc caccg 15aagugguuuc caccg 15

＜210＞ 756<210> 756

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 756<400> 756

agugguuucc accgc 15agugguuucc accgc 15

＜210＞ 757<210> 757

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 757<400> 757

gugguuucca ccgca 15gugguuucca ccgca 15

＜210＞ 758<210> 758

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 758<400> 758

uguguguugg accgu 15uguguguugg accgu 15

＜210＞ 759<210> 759

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 759<400> 759

gccggcucaa agacc 15gccggcucaa agacc 15

＜210＞ 760<210> 760

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 760<400> 760

agacccuagc cggcc 15agacccuagc cggcc 15

＜210＞ 761<210> 761

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 761<400> 761

ugcgccuccc ggggc 15ugcgccuccc ggggc 15

＜210＞ 762<210> 762

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 762<400> 762

ggcgcguucc cuuac 15ggcgcguucc cuuac 15

＜210＞ 763<210> 763

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 763<400> 763

gcgcguuccc uuaca 15gcgcguuccc uuaca 15

＜210＞ 764<210> 764

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 764<400> 764

guucccuuac accau 15guucccuuac accau 15

＜210＞ 765<210> 765

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 765<400> 765

uucccuuaca ccaug 15uucccuuaca ccaug 15

＜210＞ 766<210> 766

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus ＜400＞ 766<213> Hepatitis C Virus <400> 766

gguagcucgg accuc 15gguagcucgg accuc 15

＜210＞ 767<210> 767

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 767<400> 767

cggaccucua ucugg 15cggaccucua ucugg 15

＜210＞ 768<210> 768

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 768<400> 768

gaccucuauc ugguc 15gaccucuauc ugguc 15

＜210＞ 769<210> 769

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 769<400> 769

ccucuaucug gucac 15ccucuaucug gucac 15

＜210＞ 770<210> 770

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 770<400> 770

aucuggucac gagac 15aucuggucac gagac 15

＜210＞ 771<210> 771

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 771<400> 771

acgucauucc ggugc 15acgucauucc ggugc 15

＜210＞ 772<210> 772

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 772<400> 772

cgucauuccg gugcg 15cgucauuccg gugcg 15

＜210＞ 773<210> 773

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 773<400> 773

ugacggucgg gggag 15ugacggucgg gggag 15

＜210＞ 774<210> 774

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 774<400> 774

ggagccuacu guccc 15ggagccuacu guccc 15

＜210＞ 775<210> 775

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 775<400> 775

cuacuguccc ccaga 15cuacuguccc ccaga 15

＜210＞ 776<210> 776

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 776<400> 776

ggcucuucgg guggc 15ggcucuucgg guggc 15

＜210＞ 777<210> 777

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 777<400> 777

cacugcucug cccuu 15cacugcucug cccuu 15

＜210＞ 778<210> 778

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 778<400> 778

cugcccuucg gggca 15cugcccuucg gggca 15

＜210＞ 779<210> 779

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 779<400> 779

ugcccuucgg ggcac 15ugcccuucgg ggcac 15

＜210＞ 780<210> 780

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 780<400> 780

acgcuguagg caucu 15acgcuguagg caucu 15

＜210＞ 781<210> 781

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 781<400> 781

uaggcaucuu ccggg 15uaggcaucuu ccggg 15

＜210＞ 782<210> 782

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 782<400> 782

ggcaucuucc gggcu 15ggcaucuucc gggcu 15

＜210＞ 783<210> 783

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 783<400> 783

gcaucuuccg ggcug 15gcaucuuccg ggcug 15

＜210＞ 784<210> 784

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 784<400> 784

gggggguugc gaagg 15gggggguugc gaagg 15

＜210＞ 785<210> 785

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 785<400> 785

gagcacuaaa gugcc 15gagcacuaaa gugcc 15

＜210＞ 786<210> 786

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 786<400> 786

gcugcguacg cagcc 15gcugcguacg cagcc 15

＜210＞ 787<210> 787

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 787<400> 787

caaggguaca aggua 15caaggguaca aggua 15

＜210＞ 788<210> 788

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 788<400> 788

caucuguugc cgcca 15caucuguugc cgcca 15

＜210＞ 789<210> 789

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 789<400> 789

ccaacaucag aacug 15ccaacaucag aacug 15

＜210＞ 790<210> 790

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 790<400> 790

cugggguaag gacca 15cugggguaag gacca 15

＜210＞ 791<210> 791

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 791<400> 791

uccaccuaug guaag 15uccaccuaug guaag 15

＜210＞ 792<210> 792

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 792<400> 792

cuaugguaag uuccu 15cuaugguaag uuccu 15

＜210＞ 793<210> 793

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 793<400> 793

gguaaguucc uugcc 15gguaaguucc uugcc 15

＜210＞ 794<210> 794

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 794<400> 794

guaaguuccu ugccg 15guaaguuccu ugccg 15

＜210＞ 795<210> 795

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 795<400> 795

aguuccuugc cgacg 15aguuccuugc cgacg 15

＜210＞ 796<210> 796

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 796<400> 796

auaucauaau augug 15auaucauaau augug 15

＜210＞ 797<210> 797

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 797<400> 797

ucauaauaug ugaug 15ucauaauaug ugaug 15

＜210＞ 798<210> 798

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 798<400> 798

gcacaguccu ggacc 15gcacaguccu ggacc 15

＜210＞ 799<210> 799

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 799<400> 799

cgcggcucgu cgugc 15cgcggcucgu cgugc 15

＜210＞ 800<210> 800

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 800<400> 800

ggcucgucgu gcucg 15ggcucgucgu gcucg 15

＜210＞ 801<210> 801

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 801<400> 801

ucgugcucgc caccg 15ucgugcucgc caccg 15

＜210＞ 802<210> 802

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 802<400> 802

cccaaauauu gagga 15cccaaauauu gagga 15

＜210＞ 803<210> 803

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 803<400> 803

gcucugucca acacu 15gcucugucca acacu 15

＜210＞ 804<210> 804

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 804<400> 804

gagagauccc cuucu 15gagagauccc cuucu 15

＜210＞ 805<210> 805

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 805<400> 805

aggccauccc ccucg 15aggccauccc ccucg 15

＜210＞ 806<210> 806

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 806<400> 806

ucccccucga ggcca 15ucccccucga ggcca 15

＜210＞ 807<210> 807

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 807<400> 807

aggccaucaa ggggg 15aggccaucaa ggggg 15

＜210＞ 808<210> 808

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 808<400> 808

ugccacucca agaag 15ugccacucca agaag 15

＜210＞ 809<210> 809

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 809<400> 809

ucggaaucaa ugccg 15ucggaaucaa ugccg 15

＜210＞ 810<210> 810

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 810<400> 810

augccguagc guauu 15augccguagc guauu 15

＜210＞ 811<210> 811

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 811<400> 811

guagcguauu accgg 15guagcguauu accgg 15

＜210＞ 812<210> 812

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 812<400> 812

agcguauuac cgggg 15agcguauuac cgggg 15

＜210＞ 813<210> 813

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 813<400> 813

gcguauuacc ggggu 15gcguauuacc ggggu 15

＜210＞ 814<210> 814

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 814<400> 814

uguccgucau accga 15uguccgucau accga 15

＜210＞ 815<210> 815

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 815<400> 815

ccgucauacc gacua 15ccgucauacc gacua 15

＜210＞ 816<210> 816

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 816<400> 816

accgacuagc ggaga 15accgacuagc ggaga 15

＜210＞ 817<210> 817

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 817<400> 817

acgggcuaca ccggu 15acgggcuaca ccggu 15

＜210＞ 818<210> 818

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 818<400> 818

cggugaucga cugca 15cggugaucga cugca 15

＜210＞ 819<210> 819

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 819<400> 819

gcggugucgc gcuca 15gcggugucgc gcuca 15

＜210＞ 820<210> 820

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 820<400> 820

ucgcgcucac aacgg 15ucgcgcucac aacgg 15

＜210＞ 821<210> 821

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 821<400> 821

cugugcuugg uauga 15cugugcuugg uauga 15

＜210＞ 822<210> 822

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 822<400> 822

gcuugguaug agcuc 15gcuugguaug agcuc 15

＜210＞ 823<210> 823

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 823<400> 823

augagcucac gcccg 15augagcucac gcccg 15

＜210＞ 824<210> 824

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 824<400> 824

ugagacuaca gucag 15ugagacuaca gucag 15

＜210＞ 825<210> 825

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 825<400> 825

cuacagucag guugc 15cuacagucag guugc 15

＜210＞ 826<210> 826

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 826<400> 826

gucagguugc gggcu 15gucagguugc gggcu 15

＜210＞ 827<210> 827

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 827<400> 827

gcgggcuuac cugaa 15gcgggcuuac cugaa 15

＜210＞ 828<210> 828

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 828<400> 828

cgggcuuacc ugaau 15cgggcuuacc ugaau 15

＜210＞ 829<210> 829

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 829<400> 829

ccugaauaca ccagg 15ccugaauaca ccagg 15

＜210＞ 830<210> 830

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 830<400> 830

ccaggguugc ccguc 15ccaggguugc ccguc 15

＜210＞ 831<210> 831

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 831<400> 831

ugcccgucug ccagg 15ugcccgucug ccagg 15

＜210＞ 832<210> 832

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 832<400> 832

ggaccaucug gaguu 15ggaccaucug gaguu 15

＜210＞ 833<210> 833

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 833<400> 833

accugguagc auacc 15accugguagc auacc 15

＜210＞ 834<210> 834

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 834<400> 834

guagcauacc aagcc 15guagcauacc aagcc 15

＜210＞ 835<210> 835

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 835<400> 835

cagggcucag gcucc 15cagggcucag gcucc 15

＜210＞ 836<210> 836

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 836<400> 836

cugcuguaua ggcua 15cugcuguaua ggcua 15

＜210＞ 837<210> 837

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 837<400> 837

gcuguauagg cuagg 15gcuguauagg cuagg 15

＜210＞ 838<210> 838

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 838<400> 838

uggaggucgu cacua 15uggaggucgu cacua 15

＜210＞ 839<210> 839

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 839<400> 839

aggucgucac uagca 15aggucgucac uagca 15

＜210＞ 840<210> 840

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 840<400> 840

cgucacuagc accug 15cgucacuagc accug 15

＜210＞ 841<210> 841

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 841<400> 841

ugcugguagg cggag 15ugcugguagg cggag 15

＜210＞ 842<210> 842

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 842<400> 842

gcggaguccu ugcag 15gcggaguccu ugcag 15

＜210＞ 843<210> 843

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 843<400> 843

gaguccuugc agcuc 15gaguccuugc agcuc 15

＜210＞ 844<210> 844

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 844<400> 844

gccgcauauu gccug 15gccgcauauu gccug 15

＜210＞ 845<210> 845

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 845<400> 845

cgcauauugc cugac 15cgcauauugc cugac 15

＜210＞ 846<210> 846

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 846<400> 846

aaccgguagu guggu 15aaccgguagu guggu 15

＜210＞ 847<210> 847

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 847<400> 847

guaggaucau uuugu 15guaggaucau uuugu 15

＜210＞ 848<210> 848

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 848<400> 848

cggcuguugu ucccg 15cggcuguugu ucccg 15

＜210＞ 849<210> 849

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 849<400> 849

cuguuguucc cgaca 15cuguuguucc cgaca 15

＜210＞ 850<210> 850

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 850<400> 850

uguuguuccc gacag 15uguuguuccc gacag 15

＜210＞ 851<210> 851

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 851<400> 851

gagcaguuca agcag 15gagcaguuca agcag 15

＜210＞ 852<210> 852

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 852<400> 852

agcaguucaa gcaga 15agcaguucaa gcaga 15

＜210＞ 853<210> 853

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 853<400> 853

cgcugcuccc guggu 15cgcugcuccc guggu 15

＜210＞ 854<210> 854

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 854<400> 854

guggagucca ggugg 15guggagucca ggugg 15

＜210＞ 855<210> 855

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 855<400> 855

gggcccuuga ggccu 15gggcccuuga ggccu 15

＜210＞ 856<210> 856

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 856<400> 856

gaggccuucu gggca 15gaggccuucu gggca 15

＜210＞ 857<210> 857

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 857<400> 857

aggccuucug ggcaa 15aggccuucug ggcaa 15

＜210＞ 858<210> 858

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 858<400> 858

gcaggcuuau ccacu 15gcaggcuuau ccacu 15

＜210＞ 859<210> 859

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 859<400> 859

caggcuuauc cacuc 15caggcuuauc cacuc 15

＜210＞ 860<210> 860

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 860<400> 860

cuccuguuca acauc 15cuccuguuca acauc 15

＜210＞ 861<210> 861

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 861<400> 861

uccuguucaa caucu 15uccuguucaa caucu 15

＜210＞ 862<210> 862

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 862<400> 862

cucaacucgc uccuc 15cucaacucgc uccuc 15

＜210＞ 863<210> 863

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 863<400> 863

acucgcuccu cccag 15acucgcuccu cccag 15

＜210＞ 864<210> 864

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 864<400> 864

gcugcuucgg ccuuc 15gcugcuucgg ccuuc 15

＜210＞ 865<210> 865

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 865<400> 865

ucggccuucg ugggc 15ucggccuucg ugggc 15

＜210＞ 866<210> 866

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 866<400> 866

cggccuucgu gggcg 15cggccuucgu gggcg 15

＜210＞ 867<210> 867

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 867<400> 867

ccggcauugc cggug 15ccggcauugc cggug 15

＜210＞ 868<210> 868

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 868<400> 868

cggccauugg cagca 15cggccauugg cagca 15

＜210＞ 869<210> 869

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 869<400> 869

gcagcauagg ccuug 15gcagcauagg ccuug 15

＜210＞ 870<210> 870

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 870<400> 870

uaggccuugg gaagg 15uaggccuugg gaagg 15

＜210＞ 871<210> 871

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 871<400> 871

gcgggcuaug gagcg 15gcgggcuaug gagcg 15

＜210＞ 872<210> 872

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 872<400> 872

gugcacucgu ggcuu 15gugcacucgu ggcuu 15

＜210＞ 873<210> 873

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 873<400> 873

cguggcuuuu aaggu 15cguggcuuuu aaggu 15

＜210＞ 874<210> 874

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 874<400> 874

guggcuuuua agguc 15guggcuuuua agguc 15

＜210＞ 875<210> 875

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 875<400> 875

uggcuuuuaa gguca 15uggcuuuuaa gguca 15

＜210＞ 876<210> 876

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 876<400> 876

ggcuuuuaag gucau 15ggcuuuuaag gucau 15

＜210＞ 877<210> 877

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 877<400> 877

uuaaggucau gagcg 15uuaaggucau gagcg 15

＜210＞ 878<210> 878

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 878<400> 878

gcgcccuccg ccgag 15gcgcccuccg ccgag 15

＜210＞ 879<210> 879

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 879<400> 879

accugguuaa cuugc 15accugguuaa cuugc 15

＜210＞ 880<210> 880

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 880<400> 880

ccugguuaac uugcu 15ccugguuaac uugcu 15

＜210＞ 881<210> 881

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 881<400> 881

acuugcuccc ugcca 15acuugcuccc ugcca 15

＜210＞ 882<210> 882

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 882<400> 882

auccucuccc ccggc 15auccucuccc ccggc 15

＜210＞ 883<210> 883

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 883<400> 883

cccuggucgu cgggg 15cccuggucgu cgggg 15

＜210＞ 884<210> 884

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 884<400> 884

uggucgucgg ggucg 15uggucgucgg ggucg 15

＜210＞ 885<210> 885

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 885<400> 885

ucggggucgu gugug 15ucggggucgu gugug 15

＜210＞ 886<210> 886

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 886<400> 886

cagcaauccu gcguc 15cagcaauccu gcguc 15

＜210＞ 887<210> 887

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 887<400> 887

ccugcgucgg cacgu 15ccugcgucgg cacgu 15

＜210＞ 888<210> 888

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 888<400> 888

auagcguucg cuucg 15auagcguucg cuucg 15

＜210＞ 889<210> 889

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 889<400> 889

uagcguucgc uucgc 15uagcguucgc uucgc 15

＜210＞ 890<210> 890

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 890<400> 890

guucgcuucg cgggg 15guucgcuucg cgggg 15

＜210＞ 891<210> 891

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 891<400> 891

acggcaucau gcaaa 15acggcaucau gcaaa 15

＜210＞ 892<210> 892

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 892<400> 892

ccgaacuauu ccagg 15ccgaacuauu ccagg 15

＜210＞ 893<210> 893

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 893<400> 893

gaacuauucc agggc 15gaacuauucc agggc 15

＜210＞ 894<210> 894

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 894<400> 894

aacuauucca gggcg 15aacuauucca gggcg 15

＜210＞ 895<210> 895

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 895<400> 895

ggggacuucc acuac 15ggggacuucc acuac 15

＜210＞ 896<210> 896

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 896<400> 896

gggacuucca cuacg 15gggacuucca cuacg 15

＜210＞ 897<210> 897

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 897<400> 897

uuccacuacg ugacg 15uuccacuacg ugacg 15

＜210＞ 898<210> 898

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 898<400> 898

acaacguaaa augcc 15acaacguaaa augcc 15

＜210＞ 899<210> 899

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 899<400> 899

cccgaauucu ucacc 15cccgaauucu ucacc 15

＜210＞ 900<210> 900

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 900<400> 900

ccgaauucuu caccg 15ccgaauucuu caccg 15

＜210＞ 901<210> 901

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 901<400> 901

gaauucuuca ccgaa 15gaauucuuca ccgaa 15

＜210＞ 902<210> 902

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 902<400> 902

aauucuucac cgaau 15aauucuucac cgaau 15

＜210＞ 903<210> 903

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 903<400> 903

accgaauugg acggg 15accgaauugg acggg 15

＜210＞ 904<210> 904

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 904<400> 904

gugcgguugc acagg 15gugcgguugc acagg 15

＜210＞ 905<210> 905

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 905<400> 905

cacagguacg cuccg 15cacagguacg cuccg 15

＜210＞ 906<210> 906

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 906<400> 906

guacgcuccg gcgug 15guacgcuccg gcgug 15

＜210＞ 907<210> 907

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 907<400> 907

cagaccucuc cuacg 15cagaccucuc cuacg 15

＜210＞ 908<210> 908

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 908<400> 908

gaccucuccu acggg 15gaccucuccu acggg 15

＜210＞ 909<210> 909

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 909<400> 909

cucuccuacg ggagg 15cucuccuacg ggagg 15

＜210＞ 910<210> 910

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 910<400> 910

aggaugucac auucc 15aggaugucac auucc 15

＜210＞ 911<210> 911

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 911<400> 911

ucacauucca ggucg 15ucacauucca ggucg 15

＜210＞ 912<210> 912

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 912<400> 912

uccaggucgg gcuca 15uccaggucgg gcuca 15

＜210＞ 913<210> 913

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 913<400> 913

ucgggcucaa ccaau 15ucgggcucaa ccaau 15

＜210＞ 914<210> 914

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 914<400> 914

aaccaauacc ugguu 15aaccaauacc ugguu 15

＜210＞ 915<210> 915

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 915<400> 915

accugguugg gucac 15accugguugg gucac 15

＜210＞ 916<210> 916

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 916<400> 916

guugggucac agcuc 15guugggucac agcuc 15

＜210＞ 917<210> 917

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 917<400> 917

cacagcuccc augcg 15cacagcuccc augcg 15

＜210＞ 918<210> 918

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 918<400> 918

uaaacguagg cuggc 15uaaacguagg cuggc 15

＜210＞ 919<210> 919

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 919<400> 919

agggggucuc ccccc 15agggggucuc ccccc 15

＜210＞ 920<210> 920

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 920<400> 920

ggggucuccc cccuc 15ggggucuccc cccuc 15

＜210＞ 921<210> 921

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 921<400> 921

ccccccuccu uggcc 15ccccccuccu uggcc 15

＜210＞ 922<210> 922

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 922<400> 922

cccuccuugg ccagc 15cccuccuugg ccagc 15

＜210＞ 923<210> 923

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 923<400> 923

gccagcucuu cagcu 15gccagcucuu cagcu 15

＜210＞ 924<210> 924

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 924<400> 924

agccaauugu cugcg 15agccaauugu cugcg 15

＜210＞ 925<210> 925

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 925<400> 925

caauugucug cgccu 15caauugucug cgccu 15

＜210＞ 926<210> 926

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 926<400> 926

ccaaccuccu guggc 15ccaaccuccu guggc 15

＜210＞ 927<210> 927

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 927<400> 927

acccgcuucg agcgg 15acccgcuucg agcgg 15

＜210＞ 928<210> 928

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 928<400> 928

cccgcuucga gcgga 15cccgcuucga gcgga 15

＜210＞ 929<210> 929

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 929<400> 929

gggaaguauc cguug 15gggaaguauc cguug 15

＜210＞ 930<210> 930

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 930<400> 930

cccgcguugc ccaua 15cccgcguugc ccaua 15

＜210＞ 931<210> 931

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 931<400> 931

ugcccauaug ggcac 15ugcccauaug ggcac 15

＜210＞ 932<210> 932

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 932<400> 932

cccggauuac aaccc 15cccggauuac aaccc 15

＜210＞ 933<210> 933

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 933<400> 933

ccggauuaca acccu 15ccggauuaca acccu 15

＜210＞ 934<210> 934

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 934<400> 934

ccacuguuag agucc 15ccacuguuag agucc 15

＜210＞ 935<210> 935

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 935<400> 935

cacuguuaga guccu 15cacuguuaga guccu 15

＜210＞ 936<210> 936

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 936<400> 936

gaaaaguccg gacua 15gaaaaguccg gacua 15

＜210＞ 937<210> 937

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 937<400> 937

ccggacuacg ucccu 15ccggacuacg ucccu 15

＜210＞ 938<210> 938

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 938<400> 938

acuacguccc uccgg 15acuacguccc uccgg 15

＜210＞ 939<210> 939

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 939<400> 939

cgucccuccg gcggu 15cgucccuccg gcggu 15

＜210＞ 940<210> 940

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 940<400> 940

ugcccauugc cgccu 15ugcccauugc cgccu 15

＜210＞ 941<210> 941

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 941<400> 941

gccgccuacc acggg 15gccgccuacc acggg 15

＜210＞ 942<210> 942

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 942<400> 942

acagagucca ccgug 15acagagucca ccgug 15

＜210＞ 943<210> 943

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 943<400> 943

gcuggcuacu aagac 15gcuggcuacu aagac 15

＜210＞ 944<210> 944

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 944<400> 944

ggcuacuaag acuuu 15ggcuacuaag acuuu 15

＜210＞ 945<210> 945

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 945<400> 945

uaagacuuuc ggcag 15uaagacuuuc ggcag 15

＜210＞ 946<210> 946

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 946<400> 946

aagacuuucg gcagc 15aagacuuucg gcagc 15

＜210＞ 947<210> 947

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 947<400> 947

agacuuucgg cagcu 15agacuuucgg cagcu 15

＜210＞ 948<210> 948

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 948<400> 948

uccggaucgu cggcc 15uccggaucgu cggcc 15

＜210＞ 949<210> 949

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 949<400> 949

ggaucgucgg ccguu 15ggaucgucgg ccguu 15

＜210＞ 950<210> 950

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 950<400> 950

cggccguuga cagcg 15cggccguuga cagcg 15

＜210＞ 951<210> 951

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 951<400> 951

ucguacuccu ccaug 15ucguacuccu ccaug 15

＜210＞ 952<210> 952

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 952<400> 952

uacuccucca ugccc 15uacuccucca ugccc 15

＜210＞ 953<210> 953

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 953<400> 953

ccccccuuga ggggg 15ccccccuuga ggggg 15

＜210＞ 954<210> 954

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 954<400> 954

cccugaucuc agcga 15cccugaucuc agcga 15

＜210＞ 955<210> 955

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 955<400> 955

cugaucucag cgacg 15cugaucucag cgacg 15

＜210＞ 956<210> 956

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 956<400> 956

gacgggucuu ggucu 15gacgggucuu ggucu 15

＜210＞ 957<210> 957

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 957<400> 957

cgggucuugg ucuac 15cgggucuugg ucuac 15

＜210＞ 958<210> 958

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 958<400> 958

ucuuggucua ccgug 15ucuuggucua ccgug 15

＜210＞ 959<210> 959

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 959<400> 959

uuggucuacc gugag 15uuggucuacc gugag 15

＜210＞ 960<210> 960

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 960<400> 960

acgacaucgu cugcu 15acgacaucgu cugcu 15

＜210＞ 961<210> 961

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 961<400> 961

acaucgucug cugcu 15acaucgucug cugcu 15

＜210＞ 962<210> 962

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 962<400> 962

ugcugcucaa ugucc 15ugcugcucaa ugucc 15

＜210＞ 963<210> 963

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 963<400> 963

ucaauguccu acaca 15ucaauguccu acaca 15

＜210＞ 964<210> 964

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 964<400> 964

ugcccaucaa cgcgu 15ugcccaucaa cgcgu 15

＜210＞ 965<210> 965

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 965<400> 965

acaacauccc gcagu 15acaacauccc gcagu 15

＜210＞ 966<210> 966

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 966<400> 966

ugcaaguccu ggacg 15ugcaaguccu ggacg 15

＜210＞ 967<210> 967

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 967<400> 967

gaccacuacc gggac 15gaccacuacc gggac 15

＜210＞ 968<210> 968

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 968<400> 968

uaaggcuaaa cuucu 15uaaggcuaaa cuucu 15

＜210＞ 969<210> 969

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 969<400> 969

aacuucuauc cguag 15aacuucuauc cguag 15

＜210＞ 970<210> 970

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 970<400> 970

cuucuauccg uagaa 15cuucuauccg uagaa 15

＜210＞ 971<210> 971

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 971<400> 971

uauccguaga agaag 15uauccguaga agaag 15

＜210＞ 972<210> 972

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 972<400> 972

gccaaaucua aauuu 15gccaaaucua aauuu 15

＜210＞ 973<210> 973

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 973<400> 973

caaaucuaaa uuugg 15caaaucuaaa uuugg 15

＜210＞ 974<210> 974

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 974<400> 974

ucuaaauuug gcuau 15ucuaaauuug gcuau 15

＜210＞ 975<210> 975

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 975<400> 975

cuaaauuugg cuaug 15cuaaauuugg cuaug 15

＜210＞ 976<210> 976

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 976<400> 976

uuuggcuaug gggca 15uuuggcuaug gggca 15

＜210＞ 977<210> 977

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 977<400> 977

accacauccg cuccg 15accacauccg cuccg 15

＜210＞ 978<210> 978

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 978<400> 978

auccgcuccg ugugg 15auccgcuccg ugugg 15

＜210＞ 979<210> 979

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 979<400> 979

cucgccuuau cguau 15cucgccuuau cguau 15

＜210＞ 980<210> 980

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 980<400> 980

ucgccuuauc guauu 15ucgccuuauc guauu 15

＜210＞ 981<210> 981

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 981<400> 981

gccuuaucgu auucc 15gccuuaucgu auucc 15

＜210＞ 982<210> 982

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 982<400> 982

uccucguacg gauuc 15uccucguacg gauuc 15

＜210＞ 983<210> 983

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 983<400> 983

uacggauucc aguac 15uacggauucc aguac 15

＜210＞ 984<210> 984

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 984<400> 984

uuccaguacu cuccu 15uuccaguacu cuccu 15

＜210＞ 985<210> 985

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 985<400> 985

guacucuccu gggca 15guacucuccu gggca 15

＜210＞ 986<210> 986

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 986<400> 986

agcggguuga guucc 15agcggguuga guucc 15

＜210＞ 987<210> 987

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 987<400> 987

guugaguucc uggug 15guugaguucc uggug 15

＜210＞ 988<210> 988

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 988<400> 988

uugaguuccu gguga 15uugaguuccu gguga 15

＜210＞ 989<210> 989

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 989<400> 989

uggaaaucaa agaaa 15uggaaaucaa agaaa 15

＜210＞ 990<210> 990

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 990<400> 990

aggccauaaa gucgc 15aggccauaaa gucgc 15

＜210＞ 991<210> 991

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 991<400> 991

auaaagucgc ucacg 15auaaagucgc ucacg 15

＜210＞ 992<210> 992

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 992<400> 992

agucgcucac ggagc 15agucgcucac ggagc 15

＜210＞ 993<210> 993

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 993<400> 993

agcggcucua caucg 15agcggcucua caucg 15

＜210＞ 994<210> 994

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 994<400> 994

cggcucuaca ucggg 15cggcucuaca ucggg 15

＜210＞ 995<210> 995

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 995<400> 995

ucuacaucgg gggcc 15ucuacaucgg gggcc 15

＜210＞ 996<210> 996

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 996<400> 996

cugcgguuau cgccg 15cugcgguuau cgccg 15

＜210＞ 997<210> 997

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 997<400> 997

ugcgguuauc gccgg 15ugcgguuauc gccgg 15

＜210＞ 998<210> 998

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 998<400> 998

cgguuaucgc cggug 15cgguuaucgc cggug 15

＜210＞ 999<210> 999

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 999<400> 999

gacgacuagc ugcgg 15gacgacuagc ugcgg 15

＜210＞ 1000<210> 1000

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1000<400> 1000

ggccugucga gcugc 15ggccugucga gcugc 15

＜210＞ 1001<210> 1001

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1001<400> 1001

caaagcucca ggacu 15caaagcucca ggacu 15

＜210＞ 1002<210> 1002

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1002<400> 1002

cgaugcucgu gaacg 15cgaugcucgu gaacg 15

＜210＞ 1003<210> 1003

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1003<400> 1003

acgaccuugu cguua 15acgaccuugu cguua 15

＜210＞ 1004<210> 1004

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1004<400> 1004

accuugucgu uaucu 15accuugucgu uaucu 15

＜210＞ 1005<210> 1005

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1005<400> 1005

uugucguuau cugug 15uugucguuau cugug 15

＜210＞ 1006<210> 1006

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1006<400> 1006

agguacucug ccccc 15agguacucug ccccc 15

＜210＞ 1007<210> 1007

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1007<400> 1007

ccagaauacg acuug 15ccagaauacg acuug 15

＜210＞ 1008<210> 1008

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1008<400> 1008

ucaugcuccu ccaac 15ucaugcuccu ccaac 15

＜210＞ 1009<210> 1009

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1009<400> 1009

ugcuccucca acgug 15ugcuccucca acgug 15

＜210＞ 1010<210> 1010

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1010<400> 1010

gacgcauccg gcaaa 15gacgcauccg gcaaa 15

＜210＞ 1011<210> 1011

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1011<400> 1011

ccccccuugc acggg 15ccccccuugc acggg 15

＜210＞ 1012<210> 1012

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1012<400> 1012

aucauguaug cgccc 15aucauguaug cgccc 15

＜210＞ 1013<210> 1013

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1013<400> 1013

cccaccuuau gggca 15cccaccuuau gggca 15

＜210＞ 1014<210> 1014

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1014<400> 1014

ccaccuuaug ggcaa 15ccaccuuaug ggcaa 15

＜210＞ 1015<210> 1015

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1015<400> 1015

gaugauuuug augac 15gaugauuuug augac 15

＜210＞ 1016<210> 1016

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1016<400> 1016

gaugacucac uucuu 15gaugacucac uucuu 15

＜210＞ 1017<210> 1017

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1017<400> 1017

ccuggauugu cagau 15ccuggauugu cagau 15

＜210＞ 1018<210> 1018

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1018<400> 1018

ggauugucag aucua 15ggauugucag aucua 15

＜210＞ 1019<210> 1019

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1019<400> 1019

gucagaucua cgggg 15gucagaucua cgggg 15

＜210＞ 1020<210> 1020

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1020<400> 1020

cagaucuacg gggcc 15cagaucuacg gggcc 15

＜210＞ 1021<210> 1021

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1021<400> 1021

caugccucag gaaac 15caugccucag gaaac 15

＜210＞ 1022<210> 1022

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1022<400> 1022

ggaaacuugg gguac 15ggaaacuugg gguac 15

＜210＞ 1023<210> 1023

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1023<400> 1023

uugggguacc gcccu 15uugggguacc gcccu 15

＜210＞ 1024<210> 1024

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1024<400> 1024

ccgcccuugc gaguc 15ccgcccuugc gaguc 15

＜210＞ 1025<210> 1025

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1025<400> 1025

ugcgagucug gagac 15ugcgagucug gagac 15

＜210＞ 1026<210> 1026

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1026<400> 1026

gaaguguccg cgcua 15gaaguguccg cgcua 15

＜210＞ 1027<210> 1027

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1027<400> 1027

ccgcgcuagg cuacu 15ccgcgcuagg cuacu 15

＜210＞ 1028<210> 1028

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1028<400> 1028

cuaggcuacu guccc 15cuaggcuacu guccc 15

＜210＞ 1029<210> 1029

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1029<400> 1029

cuacuguccc aaggg 15cuacuguccc aaggg 15

＜210＞ 1030<210> 1030

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1030<400> 1030

gccgcguccc agcug 15gccgcguccc agcug 15

＜210＞ 1031<210> 1031

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1031<400> 1031

cuggacuugu ccagc 15cuggacuugu ccagc 15

＜210＞ 1032<210> 1032

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1032<400> 1032

gacuugucca gcugg 15gacuugucca gcugg 15

＜210＞ 1033<210> 1033

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1033<400> 1033

agcugguucg uugcu 15agcugguucg uugcu 15

＜210＞ 1034<210> 1034

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1034<400> 1034

gcugguucgu ugcug 15gcugguucgu ugcug 15

＜210＞ 1035<210> 1035

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1035<400> 1035

gguucguugc ugguu 15gguucguugc ugguu 15

＜210＞ 1036<210> 1036

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1036<400> 1036

gagacauaua ucaca 15gagacauaua ucaca 15

＜210＞ 1037<210> 1037

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1037<400> 1037

gacauauauc acagc 15gacauauauc acagc 15

＜210＞ 1038<210> 1038

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1038<400> 1038

cauauaucac agccu 15cauauaucac agccu 15

＜210＞ 1039<210> 1039

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1039<400> 1039

agccugucuc gugcc 15agccugucuc gugcc 15

＜210＞ 1040<210> 1040

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1040<400> 1040

ggugccuacu ccuac 15ggugccuacu ccuac 15

＜210＞ 1041<210> 1041

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1041<400> 1041

gccuacuccu acuuu 15gccuacuccu acuuu 15

＜210＞ 1042<210> 1042

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1042<400> 1042

uacuccuacu uuccg 15uacuccuacu uuccg 15

＜210＞ 1043<210> 1043

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1043<400> 1043

uccuacuuuc cguag 15uccuacuuuc cguag 15

＜210＞ 1044<210> 1044

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1044<400> 1044

ccuacuuucc guagg 15ccuacuuucc guagg 15

＜210＞ 1045<210> 1045

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1045<400> 1045

cuacuuuccg uaggg 15cuacuuuccg uaggg 15

＜210＞ 1046<210> 1046

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1046<400> 1046

uuuccguagg gguag 15uuuccguagg gguag 15

＜210＞ 1047<210> 1047

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1047<400> 1047

uagggguagg caucu 15uagggguagg caucu 15

＜210＞ 1048<210> 1048

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1048<400> 1048

uaggcaucua ccugc 15uaggcaucua ccugc 15

＜210＞ 1049<210> 1049

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1049<400> 1049

ggcaucuacc ugcuc 15ggcaucuacc ugcuc 15

＜210＞ 1050<210> 1050

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1050<400> 1050

accugcuccc caacc 15accugcuccc caacc 15

＜210＞ 1051<210> 1051

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1051<400> 1051

gggagcuaau cacuc 15gggagcuaau cacuc 15

＜210＞ 1052<210> 1052

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1052<400> 1052

agcuaaucac uccag 15agcuaaucac uccag 15

＜210＞ 1053<210> 1053

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1053<400> 1053

aaucacucca ggcca 15aaucacucca ggcca 15

＜210＞ 1054<210> 1054

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1054<400> 1054

ggccaauagg ccauc 15ggccaauagg ccauc 15

＜210＞ 1055<210> 1055

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1055<400> 1055

cgccccccug augagncgaa aucgggg 27cgccccccug augagncgaa aucgggg 27

＜210＞ 1056<210> 1056

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1056<400> 1056

agugauccug augagncgaa auggugg 27agugauccug augagncgaa auggugg 27

＜210＞ 1057<210> 1057

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1057<400> 1057

ggggagucug augagncgaa aucuaug 27ggggagucug augagncgaa aucuaug 27

＜210＞ 1058<210> 1058

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1058<400> 1058

cacagggcug augagncgaa agugauc 27cacagggcug augagncgaa agugauc 27

＜210＞ 1059<210> 1059

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1059<400> 1059

aagacagcug augagncgaa aguuccu 27aagacagcug augagncgaa aguuccu 27

＜210＞ 1060<210> 1060

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1060<400> 1060

gcgugaacug augagncgaa acaguag 27gcgugaacug augagncgaa acaguag 27

＜210＞ 1061<210> 1061

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1061<400> 1061

cugcgugcug augagncgaa agacagu 27cugcgugcug augagncgaa agacagu 27

＜210＞ 1062<210> 1062

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1062<400> 1062

ucugcgucug augagncgaa aagacag 27ucugcgucug augagncgaa aagacag 27

＜210＞ 1063<210> 1063

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1063<400> 1063

auggcuacug augagncgaa acgcuuu 27auggcuacug augagncgaa acgcuuu 27

＜210＞ 1064<210> 1064

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1064<400> 1064

ccauggccug augagncgaa agacgcu 27ccauggccug augagncgaa agacgcu 27

＜210＞ 1065<210> 1065

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1065<400> 1065

ucauacucug augagncgaa acgccau 27ucauacucug augagncgaa acgccau 27

＜210＞ 1066<210> 1066

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1066<400> 1066

cucauaccug augagncgaa aacgcca 27cucauaccug augagncgaa aacgcca 27

＜210＞ 1067<210> 1067

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1067<400> 1067

acacucacug augagncgaa acuaacg 27acacucacug augagncgaa acuaacg 27

＜210＞ 1068<210> 1068

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1068<400> 1068

gcugcaccug augagncgaa acacuca 27gcugcaccug augagncgaa acacuca 27

＜210＞ 1069<210> 1069

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1069<400> 1069

agaccaccug augagncgaa auggcuc 27agaccaccug augagncgaa auggcuc 27

＜210＞ 1070<210> 1070

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1070<400> 1070

aagaaagcug augagncgaa acccggu 27aagaaagcug augagncgaa acccggu 27

＜210＞ 1071<210> 1071

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1071<400> 1071

uccaagacug augagncgaa aggaccc 27uccaagacug augagncgaa aggaccc 27

＜210＞ 1072<210> 1072

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1072<400> 1072

auccaagcug augagncgaa aaggacc 27auccaagcug augagncgaa aaggacc 27

＜210＞ 1073<210> 1073

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1073<400> 1073

gauccaacug augagncgaa aaaggac 27gauccaacug augagncgaa aaaggac 27

＜210＞ 1074<210> 1074

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1074<400> 1074

gcggguucug augagncgaa auccaag 27gcggguucug augagncgaa auccaag 27

＜210＞ 1075<210> 1075

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1075<400> 1075

acgcccacug augagncgaa aucucca 27acgcccacug augagncgaa aucucca 27

＜210＞ 1076<210> 1076

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1076<400> 1076

cacgccccug augagncgaa aaucucc 27cacgccccug augagncgaa aaucucc 27

＜210＞ 1077<210> 1077

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1077<400> 1077

guaccaccug augagncgaa aggccuu 27guaccaccug augagncgaa aggccuu 27

＜210＞ 1078<210> 1078

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1078<400> 1078

gguuuagcug augagncgaa auucgug 27gguuuagcug augagncgaa auucgug 27

＜210＞ 1079<210> 1079

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1079<400> 1079

ugagguucug augagncgaa aggauuc 27ugagguucug augagncgaa aggauuc 27

＜210＞ 1080<210> 1080

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1080<400> 1080

uuucuuucug augagncgaa agguuua 27uuucuuucug augagncgaa agguuua 27

＜210＞ 1081<210> 1081

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1081<400> 1081

uaggugucug augagncgaa acguuug 27uaggugucug augagncgaa acguuug 27

＜210＞ 1082<210> 1082

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1082<400> 1082

gcggcggcug augagncgaa agguguu 27gcggcggcug augagncgaa agguguu 27

＜210＞ 1083<210> 1083

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1083<400> 1083

caccaaccug augagncgaa aucugac 27caccaaccug augagncgaa aucugac 27

＜210＞ 1084<210> 1084

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1084<400> 1084

cuccacccug augagncgaa acgaucu 27cuccacccug augagncgaa acgaucu 27

＜210＞ 1085<210> 1085

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1085<400> 1085

acacguacug augagncgaa acuccac 27acacguacug augagncgaa acuccac 27

＜210＞ 1086<210> 1086

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1086<400> 1086

aacacgucug augagncgaa aacucca 27aacacgucug augagncgaa aacucca 27

＜210＞ 1087<210> 1087

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1087<400> 1087

caacacgcug augagncgaa aaacucc 27caacacgcug augagncgaa aaacucc 27

＜210＞ 1088<210> 1088

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1088<400> 1088

gcgcggccug augagncgaa acacgua 27gcgcggccug augagncgaa acacgua 27

＜210＞ 1089<210> 1089

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1089<400> 1089

cuuccaccug augagncgaa agguugc 27cuuccaccug augagncgaa agguugc 27

＜210＞ 1090<210> 1090

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1090<400> 1090

auugcgccug augagncgaa accuccg 27auugcgccug augagncgaa accuccg 27

＜210＞ 1091<210> 1091

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1091<400> 1091

augaccucug augagncgaa acccaga 27augaccucug augagncgaa acccaga 27

＜210＞ 1092<210> 1092

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1092<400> 1092

cgcacgucug augagncgaa aggguau 27cgcacgucug augagncgaa aggguau 27

＜210＞ 1093<210> 1093

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1093<400> 1093

accccaucug augagncgaa aggucgg 27accccaucug augagncgaa aggucgg 27

＜210＞ 1094<210> 1094

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1094<400> 1094

auagagacug augagncgaa agagcaa 27auagagacug augagncgaa agagcaa 27

＜210＞ 1095<210> 1095

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1095<400> 1095

gauagagcug augagncgaa aagagca 27gauagagcug augagncgaa aagagca 27

＜210＞ 1096<210> 1096

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1096<400> 1096

agauagacug augagncgaa aaagagc 27agauagacug augagncgaa aaagagc 27

＜210＞ 1097<210> 1097

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1097<400> 1097

gaagauacug augagncgaa agaaaga 27gaagauacug augagncgaa agaaaga 27

＜210＞ 1098<210> 1098

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1098<400> 1098

aggaagacug augagncgaa agagaaa 27aggaagacug augagncgaa agagaaa 27

＜210＞ 1099<210> 1099

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1099<400> 1099

agaggaacug augagncgaa auagaga 27agaggaacug augagncgaa auagaga 27

＜210＞ 1100<210> 1100

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1100<400> 1100

caagaggcug augagncgaa agauaga 27caagaggcug augagncgaa agauaga 27

＜210＞ 1101<210> 1101

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1101<400> 1101

ccaagagcug augagncgaa aagauag 27ccaagagcug augagncgaa aagauag 27

＜210＞ 1102<210> 1102

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1102<400> 1102

gggccaacug augagncgaa aggaaga 27gggccaacug augagncgaa aggaaga 27

＜210＞ 1103<210> 1103

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1103<400> 1103

cagggcccug augagncgaa agaggaa 27cagggcccug augagncgaa agaggaa 27

＜210＞ 1104<210> 1104

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1104<400> 1104

caaacagcug augagncgaa acagcag 27caaacagcug augagncgaa acagcag 27

＜210＞ 1105<210> 1105

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1105<400> 1105

auggucacug augagncgaa acaggac 27auggucacug augagncgaa acaggac 27

＜210＞ 1106<210> 1106

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1106<400> 1106

gaugguccug augagncgaa aacagga 27gaugguccug augagncgaa aacagga 27

＜210＞ 1107<210> 1107

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1107<400> 1107

aagcuggcug augagncgaa augguca 27aagcuggcug augagncgaa augguca 27

＜210＞ 1108<210> 1108

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1108<400> 1108

uaagcggcug augagncgaa agcuggg 27uaagcggcug augagncgaa agcuggg 27

＜210＞ 1109<210> 1109

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1109<400> 1109

auaagcgcug augagncgaa aagcugg 27auaagcgcug augagncgaa aagcugg 27

＜210＞ 1110<210> 1110

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1110<400> 1110

accugaucug augagncgaa agcggaa 27accugaucug augagncgaa agcggaa 27

＜210＞ 1111<210> 1111

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1111<400> 1111

caccugacug augagncgaa aagcgga 27caccugacug augagncgaa aagcgga 27

＜210＞ 1112<210> 1112

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1112<400> 1112

cgcaccucug augagncgaa auaagcg 27cgcaccucug augagncgaa auaagcg 27

＜210＞ 1113<210> 1113

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1113<400> 1113

cagcccgcug augagncgaa augcguu 27cagcccgcug augagncgaa augcguu 27

＜210＞ 1114<210> 1114

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1114<400> 1114

gacauggcug augagncgaa acagccc 27gacauggcug augagncgaa acagccc 27

＜210＞ 1115<210> 1115

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1115<400> 1115

cauucgucug augagncgaa acauggu 27cauucgucug augagncgaa acauggu 27

＜210＞ 1116<210> 1116

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1116<400> 1116

ugaguugcug augagncgaa agcaguc 27ugaguugcug augagncgaa agcaguc 27

＜210＞ 1117<210> 1117

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1117<400> 1117

aaugcuucug augagncgaa aguugga 27aaugcuucug augagncgaa aguugga 27

＜210＞ 1118<210> 1118

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1118<400> 1118

cauacaccug augagncgaa augcuug 27cauacaccug augagncgaa augcuug 27

＜210＞ 1119<210> 1119

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1119<400> 1119

ccgggggcug augagncgaa augcaug 27ccgggggcug augagncgaa augcaug 27

＜210＞ 1120<210> 1120

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1120<400> 1120

ugggagucug augagncgaa agcgcua 27ugggagucug augagncgaa agcgcua 27

＜210＞ 1121<210> 1121

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1121<400> 1121

agcguggcug augagncgaa agugagc 27agcguggcug augagncgaa agugagc 27

＜210＞ 1122<210> 1122

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1122<400> 1122

uggccgccug augagncgaa agcgugg 27uggccgccug augagncgaa agcgugg 27

＜210＞ 1123<210> 1123

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1123<400> 1123

uagugggcug augagncgaa augcugg 27uagugggcug augagncgaa augcugg 27

＜210＞ 1124<210> 1124

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1124<400> 1124

auugucgcug augagncgaa agugggg 27auugucgcug augagncgaa agugggg 27

＜210＞ 1125<210> 1125

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1125<400> 1125

ggcgucgcug augagncgaa auugucg 27ggcgucgcug augagncgaa auugucg 27

＜210＞ 1126<210> 1126

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1126<400> 1126

gaacagacug augagncgaa agcggcc 27gaacagacug augagncgaa agcggcc 27

＜210＞ 1127<210> 1127

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1127<400> 1127

auccgcacug augagncgaa agguccc 27auccgcacug augagncgaa agguccc 27

＜210＞ 1128<210> 1128

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1128<400> 1128

gggagaccug augagncgaa aggaaaa 27gggagaccug augagncgaa aggaaaa 27

＜210＞ 1129<210> 1129

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1129<400> 1129

acugggacug augagncgaa acgagga 27acugggacug augagncgaa acgagga 27

＜210＞ 1130<210> 1130

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1130<400> 1130

caacuggcug augagncgaa agacgag 27caacuggcug augagncgaa agacgag 27

＜210＞ 1131<210> 1131

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1131<400> 1131

ggugaaccug augagncgaa acuggga 27ggugaaccug augagncgaa acuggga 27

＜210＞ 1132<210> 1132

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1132<400> 1132

gaaggugcug augagncgaa acaacug 27gaaggugcug augagncgaa acaacug 27

＜210＞ 1133<210> 1133

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1133<400> 1133

agaaggucug augagncgaa aacaacu 27agaaggucug augagncgaa aacaacu 27

＜210＞ 1134<210> 1134

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1134<400> 1134

aggcgagcug augagncgaa aggugaa 27aggcgagcug augagncgaa aggugaa 27

＜210＞ 1135<210> 1135

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1135<400> 1135

gaggcgacug augagncgaa aagguga 27gaggcgacug augagncgaa aagguga 27

＜210＞ 1136<210> 1136

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1136<400> 1136

gcgaggccug augagncgaa agaaggu 27gcgaggccug augagncgaa agaaggu 27

＜210＞ 1137<210> 1137

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1137<400> 1137

uaccggccug augagncgaa aggcgag 27uaccggccug augagncgaa aggcgag 27

＜210＞ 1138<210> 1138

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1138<400> 1138

ugucucacug augagncgaa accggcg 27ugucucacug augagncgaa accggcg 27

＜210＞ 1139<210> 1139

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1139<400> 1139

aguccugcug augagncgaa acugucu 27aguccugcug augagncgaa acugucu 27

＜210＞ 1140<210> 1140

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1140<400> 1140

auugagccug augagncgaa auugcag 27auugagccug augagncgaa auugcag 27

＜210＞ 1141<210> 1141

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1141<400> 1141

auagauucug augagncgaa agcaauu 27auagauucug augagncgaa agcaauu 27

＜210＞ 1142<210> 1142

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1142<400> 1142

cgggauacug augagncgaa auugagc 27cgggauacug augagncgaa auugagc 27

＜210＞ 1143<210> 1143

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1143<400> 1143

gccgggacug augagncgaa agauuga 27gccgggacug augagncgaa agauuga 27

＜210＞ 1144<210> 1144

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1144<400> 1144

uggccggcug augagncgaa auagauu 27uggccggcug augagncgaa auagauu 27

＜210＞ 1145<210> 1145

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1145<400> 1145

auauccccug augagncgaa agccaug 27auauccccug augagncgaa agccaug 27

＜210＞ 1146<210> 1146

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1146<400> 1146

aucaucacug augagncgaa aucccaa 27aucaucacug augagncgaa aucccaa 27

＜210＞ 1147<210> 1147

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1147<400> 1147

uguaggccug augagncgaa accaguu 27uguaggccug augagncgaa accaguu 27

＜210＞ 1148<210> 1148

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1148<400> 1148

gcuguugcug augagncgaa aggcgac 27gcuguugcug augagncgaa aggcgac 27

＜210＞ 1149<210> 1149

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1149<400> 1149

acaccaccug augagncgaa agggcug 27acaccaccug augagncgaa agggcug 27

＜210＞ 1150<210> 1150

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1150<400> 1150

uaacugccug augagncgaa acaccac 27uaacugccug augagncgaa acaccac 27

＜210＞ 1151<210> 1151

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1151<400> 1151

ccggagucug augagncgaa acugcga 27ccggagucug augagncgaa acugcga 27

＜210＞ 1152<210> 1152

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1152<400> 1152

uccggagcug augagncgaa aacugcg 27uccggagcug augagncgaa aacugcg 27

＜210＞ 1153<210> 1153

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1153<400> 1153

ggauccgcug augagncgaa aguaacu 27ggauccgcug augagncgaa aguaacu 27

＜210＞ 1154<210> 1154

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1154<400> 1154

cuuguggcug augagncgaa auccgga 27cuuguggcug augagncgaa auccgga 27

＜210＞ 1155<210> 1155

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1155<400> 1155

aagaccucug augagncgaa agcccag 27aagaccucug augagncgaa agcccag 27

＜210＞ 1156<210> 1156

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1156<400> 1156

caaucaacug augagncgaa accuuag 27caaucaacug augagncgaa accuuag 27

＜210＞ 1157<210> 1157

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1157<400> 1157

cacaauccug augagncgaa agaccuu 27cacaauccug augagncgaa agaccuu 27

＜210＞ 1158<210> 1158

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1158<400> 1158

acaucaccug augagncgaa aucaaga 27acaucaccug augagncgaa aucaaga 27

＜210＞ 1159<210> 1159

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1159<400> 1159

aaagagucug augagncgaa acaucac 27aaagagucug augagncgaa acaucac 27

＜210＞ 1160<210> 1160

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1160<400> 1160

caaagagcug augagncgaa aacauca 27caaagagcug augagncgaa aacauca 27

＜210＞ 1161<210> 1161

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1161<400> 1161

cggcaaacug augagncgaa aguaaca 27cggcaaacug augagncgaa aguaaca 27

＜210＞ 1162<210> 1162

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1162<400> 1162

gccggcacug augagncgaa agaguaa 27gccggcacug augagncgaa agaguaa 27

＜210＞ 1163<210> 1163

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1163<400> 1163

cgccggccug augagncgaa aagagua 27cgccggccug augagncgaa aagagua 27

＜210＞ 1164<210> 1164

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1164<400> 1164

ccccguccug augagncgaa acgccgg 27ccccguccug augagncgaa acgccgg 27

＜210＞ 1165<210> 1165

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1165<400> 1165

uguaagucug augagncgaa accccgu 27uguaagucug augagncgaa accccgu 27

＜210＞ 1166<210> 1166

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1166<400> 1166

gucgugucug augagncgaa agugacc 27gucgugucug augagncgaa agugacc 27

＜210＞ 1167<210> 1167

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1167<400> 1167

ugucgugcug augagncgaa aagugac 27ugucgugcug augagncgaa aagugac 27

＜210＞ 1168<210> 1168

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1168<400> 1168

agcuugccug augagncgaa acccccc 27agcuugccug augagncgaa acccccc 27

＜210＞ 1169<210> 1169

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1169<400> 1169

guguggccug augagncgaa agcuugc 27guguggccug augagncgaa agcuugc 27

＜210＞ 1170<210> 1170

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1170<400> 1170

aggacgucug augagncgaa acgcucu 27aggacgucug augagncgaa acgcucu 27

＜210＞ 1171<210> 1171

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1171<400> 1171

gaagaagcug augagncgaa acgugac 27gaagaagcug augagncgaa acgugac 27

＜210＞ 1172<210> 1172

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1172<400> 1172

ggugaagcug augagncgaa aggacgu 27ggugaagcug augagncgaa aggacgu 27

＜210＞ 1173<210> 1173

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1173<400> 1173

gggugaacug augagncgaa aaggacg 27gggugaacug augagncgaa aaggacg 27

＜210＞ 1174<210> 1174

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1174<400> 1174

uugggugcug augagncgaa agaagga 27uugggugcug augagncgaa agaagga 27

＜210＞ 1175<210> 1175

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1175<400> 1175

cuugggucug augagncgaa aagaagg 27cuugggucug augagncgaa aagaagg 27

＜210＞ 1176<210> 1176

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1176<400> 1176

ugagcugcug augagncgaa auucucu 27ugagcugcug augagncgaa auucucu 27

＜210＞ 1177<210> 1177

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1177<400> 1177

uguuuaucug augagncgaa agcugga 27uguuuaucug augagncgaa agcugga 27

＜210＞ 1178<210> 1178

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1178<400> 1178

ugguguucug augagncgaa augagcu 27ugguguucug augagncgaa augagcu 27

＜210＞ 1179<210> 1179

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1179<400> 1179

uccuguucug augagncgaa augugcc 27uccuguucug augagncgaa augugcc 27

＜210＞ 1180<210> 1180

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1180<400> 1180

guugaggcug augagncgaa auucauu 27guugaggcug augagncgaa auucauu 27

＜210＞ 1181<210> 1181

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1181<400> 1181

cgguguucug augagncgaa agggauu 27cgguguucug augagncgaa agggauu 27

＜210＞ 1182<210> 1182

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1182<400> 1182

ggcaaagcug augagncgaa acccggu 27ggcaaagcug augagncgaa acccggu 27

＜210＞ 1183<210> 1183

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1183<400> 1183

cggcaaacug augagncgaa aacccgg 27cggcaaacug augagncgaa aacccgg 27

＜210＞ 1184<210> 1184

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1184<400> 1184

ugcggcacug augagncgaa agaaccc 27ugcggcacug augagncgaa agaaccc 27

＜210＞ 1185<210> 1185

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1185<400> 1185

gugcggccug augagncgaa aagaacc 27gugcggccug augagncgaa aagaacc 27

＜210＞ 1186<210> 1186

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1186<400> 1186

ugcguagcug augagncgaa acagugc 27ugcguagcug augagncgaa acagugc 27

＜210＞ 1187<210> 1187

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1187<400> 1187

gugcguacug augagncgaa aacagug 27gugcguacug augagncgaa aacagug 27

＜210＞ 1188<210> 1188

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1188<400> 1188

gugugcgcug augagncgaa agaacag 27gugugcgcug augagncgaa agaacag 27

＜210＞ 1189<210> 1189

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1189<400> 1189

cgaguugcug augagncgaa acuugug 27cgaguugcug augagncgaa acuugug 27

＜210＞ 1190<210> 1190

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1190<400> 1190

acgaguucug augagncgaa aacuugu 27acgaguucug augagncgaa aacuugu 27

＜210＞ 1191<210> 1191

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1191<400> 1191

uccggaccug augagncgaa aguugaa 27uccggaccug augagncgaa aguugaa 27

＜210＞ 1192<210> 1192

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1192<400> 1192

gcauccgcug augagncgaa acgaguu 27gcauccgcug augagncgaa acgaguu 27

＜210＞ 1193<210> 1193

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1193<400> 1193

gucgaugcug augagncgaa agcugca 27gucgaugcug augagncgaa agcugca 27

＜210＞ 1194<210> 1194

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1194<400> 1194

ggcucggcug augagncgaa auaggug 27ggcucggcug augagncgaa auaggug 27

＜210＞ 1195<210> 1195

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1195<400> 1195

agguccccug augagncgaa aggcucg 27agguccccug augagncgaa aggcucg 27

＜210＞ 1196<210> 1196

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1196<400> 1196

ggccucucug augagncgaa auccagg 27ggccucucug augagncgaa auccagg 27

＜210＞ 1197<210> 1197

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1197<400> 1197

cagcagucug augagncgaa aggccuc 27cagcagucug augagncgaa aggccuc 27

＜210＞ 1198<210> 1198

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1198<400> 1198

gaaacagcug augagncgaa acacugg 27gaaacagcug augagncgaa acacugg 27

＜210＞ 1199<210> 1199

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1199<400> 1199

ggggugacug augagncgaa acaguac 27ggggugacug augagncgaa acaguac 27

＜210＞ 1200<210> 1200

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1200<400> 1200

uggggugcug augagncgaa aacagua 27uggggugcug augagncgaa aacagua 27

＜210＞ 1201 ＜211＞ 27<210> 1201 <211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1201<400> 1201

uuggggucug augagncgaa aaacagu 27uuggggucug augagncgaa aaacagu 27

＜210＞ 1202<210> 1202

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1202<400> 1202

uguugagcug augagncgaa agcagca 27uguugagcug augagncgaa agcagca 27

＜210＞ 1203<210> 1203

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1203<400> 1203

uuguugacug augagncgaa aagcagc 27uuguugacug augagncgaa aagcagc 27

＜210＞ 1204<210> 1204

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1204<400> 1204

uguuguucug augagncgaa agaagca 27uguuguucug augagncgaa agaagca 27

＜210＞ 1205<210> 1205

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1205<400> 1205

cuuggugcug augagncgaa acccagu 27cuuggugcug augagncgaa acccagu 27

＜210＞ 1206<210> 1206

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1206<400> 1206

ucuuggucug augagncgaa aacccag 27ucuuggucug augagncgaa aacccag 27

＜210＞ 1207<210> 1207

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1207<400> 1207

cgaaagccug augagncgaa auccgug 27cgaaagccug augagncgaa auccgug 27

＜210＞ 1208<210> 1208

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1208<400> 1208

cuuccgacug augagncgaa agcaauc 27cuuccgacug augagncgaa agcaauc 27

＜210＞ 1209<210> 1209

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1209<400> 1209

gcuuccgcug augagncgaa aagcaau 27gcuuccgcug augagncgaa aagcaau 27

＜210＞ 1210<210> 1210

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1210<400> 1210

ugcuucccug augagncgaa aaagcaa 27ugcuucccug augagncgaa aaagcaa 27

＜210＞ 1211<210> 1211

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1211<400> 1211

auacacccug augagncgaa agguguu 27auacacccug augagncgaa agguguu 27

＜210＞ 1212<210> 1212

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1212<400> 1212

ucaacuacug augagncgaa acaccua 27ucaacuacug augagncgaa acaccua 27

＜210＞ 1213<210> 1213

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1213<400> 1213

agucaaccug augagncgaa auacacc 27agucaaccug augagncgaa auacacc 27

＜210＞ 1214<210> 1214

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1214<400> 1214

gguaguccug augagncgaa acuauac 27gguaguccug augagncgaa acuauac 27

＜210＞ 1215<210> 1215

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1215<400> 1215

guaugggcug augagncgaa agucaac 27guaugggcug augagncgaa agucaac 27

＜210＞ 1216<210> 1216

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1216<400> 1216

gagccugcug augagncgaa augggua 27gagccugcug augagncgaa augggua 27

＜210＞ 1217<210> 1217

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1217<400> 1217

agugccacug augagncgaa agccugu 27agugccacug augagncgaa agccugu 27

＜210＞ 1218<210> 1218

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1218<400> 1218

gcaggggcug augagncgaa agugcca 27gcaggggcug augagncgaa agugcca 27

＜210＞ 1219<210> 1219

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1219<400> 1219

uaaaguucug augagncgaa acagugc 27uaaaguucug augagncgaa acagugc 27

＜210＞ 1220<210> 1220

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1220<400> 1220

gaugguacug augagncgaa aguugac 27gaugguacug augagncgaa aguugac 27

＜210＞ 1221<210> 1221

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1221<400> 1221

agauggucug augagncgaa aaguuga 27agauggucug augagncgaa aaguuga 27

＜210＞ 1222<210> 1222

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1222<400> 1222

aagauggcug augagncgaa aaaguug 27aagauggcug augagncgaa aaaguug 27

＜210＞ 1223<210> 1223

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1223<400> 1223

uaaccuucug augagncgaa aagaugg 27uaaccuucug augagncgaa aagaugg 27

＜210＞ 1224<210> 1224

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1224<400> 1224

cuaaccucug augagncgaa aaagaug 27cuaaccucug augagncgaa aaagaug 27

＜210＞ 1225<210> 1225

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1225<400> 1225

acauccucug augagncgaa accuuaa 27acauccucug augagncgaa accuuaa 27

＜210＞ 1226<210> 1226

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1226<400> 1226

uacaucccug augagncgaa aaccuua 27uacaucccug augagncgaa aaccuua 27

＜210＞ 1227<210> 1227

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1227<400> 1227

ccccacacug augagncgaa acauccu 27ccccacacug augagncgaa acauccu 27

＜210＞ 1228<210> 1228

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1228<400> 1228

ucuccuccug augagncgaa aguccag 27ucuccuccug augagncgaa aguccag 27

＜210＞ 1229<210> 1229

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1229<400> 1229

aacagggcug augagncgaa agugucu 27aacagggcug augagncgaa agugucu 27

＜210＞ 1230<210> 1230

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1230<400> 1230

gaacaggcug augagncgaa aaguguc 27gaacaggcug augagncgaa aaguguc 27

＜210＞ 1231<210> 1231

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1231<400> 1231

gugaaggcug augagncgaa acaggga 27gugaaggcug augagncgaa acaggga 27

＜210＞ 1232<210> 1232

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1232<400> 1232

ggugaagcug augagncgaa aacaggg 27ggugaagcug augagncgaa aacaggg 27

＜210＞ 1233<210> 1233

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1233<400> 1233

gguggugcug augagncgaa aggaaca 27gguggugcug augagncgaa aggaaca 27

＜210＞ 1234<210> 1234

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1234<400> 1234

ggguggucug augagncgaa aaggaac 27ggguggucug augagncgaa aaggaac 27

＜210＞ 1235<210> 1235

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1235<400> 1235

gagccggcug augagncgaa agggugg 27gagccggcug augagncgaa agggugg 27

＜210＞ 1236<210> 1236

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1236<400> 1236

guggacacug augagncgaa agccggu 27guggacacug augagncgaa agccggu 27

＜210＞ 1237<210> 1237

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1237<400> 1237

accagugcug augagncgaa acagagc 27accagugcug augagncgaa acagagc 27

＜210＞ 1238<210> 1238

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1238<400> 1238

uggaucacug augagncgaa accagug 27uggaucacug augagncgaa accagug 27

＜210＞ 1239<210> 1239

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1239<400> 1239

guggauccug augagncgaa aaccagu 27guggauccug augagncgaa aaccagu 27

＜210＞ 1240<210> 1240

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1240<400> 1240

ggaggugcug augagncgaa aucaaac 27ggaggugcug augagncgaa aucaaac 27

＜210＞ 1241<210> 1241

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1241<400> 1241

guacaggcug augagncgaa acugcac 27guacaggcug augagncgaa acugcac 27

＜210＞ 1242<210> 1242

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1242<400> 1242

uauaccgcug augagncgaa acaggua 27uauaccgcug augagncgaa acaggua 27

＜210＞ 1243<210> 1243

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1243<400> 1243

gacccuacug augagncgaa accguac 27gacccuacug augagncgaa accguac 27

＜210＞ 1244<210> 1244

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1244<400> 1244

cugaccccug augagncgaa auaccgu 27cugaccccug augagncgaa auaccgu 27

＜210＞ 1245<210> 1245

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1245<400> 1245

aaccgcucug augagncgaa acccuau 27aaccgcucug augagncgaa acccuau 27

＜210＞ 1246<210> 1246

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1246<400> 1246

aggagaccug augagncgaa accgcug 27aggagaccug augagncgaa accgcug 27

＜210＞ 1247<210> 1247

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1247<400> 1247

caaaggacug augagncgaa acaaccg 27caaaggacug augagncgaa acaaccg 27

＜210＞ 1248<210> 1248

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1248<400> 1248

cacaaagcug augagncgaa agacaac 27cacaaagcug augagncgaa agacaac 27

＜210＞ 1249<210> 1249

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1249<400> 1249

gaucacacug augagncgaa aggagac 27gaucacacug augagncgaa aggagac 27

＜210＞ 1250<210> 1250

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1250<400> 1250

ugaucaccug augagncgaa aaggaga 27ugaucaccug augagncgaa aaggaga 27

＜210＞ 1251<210> 1251

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1251<400> 1251

cccauuucug augagncgaa aucacaa 27cccauuucug augagncgaa aucacaa 27

＜210＞ 1252<210> 1252

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1252<400> 1252

cacgauacug augagncgaa acuccca 27cacgauacug augagncgaa acuccca 27

＜210＞ 1253<210> 1253

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1253<400> 1253

aacacgacug augagncgaa auacucc 27aacacgacug augagncgaa auacucc 27

＜210＞ 1254<210> 1254

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1254<400> 1254

gcaacaccug augagncgaa auauacu 27gcaacaccug augagncgaa auauacu 27

＜210＞ 1255<210> 1255

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1255<400> 1255

gaaaagccug augagncgaa acacgau 27gaaaagccug augagncgaa acacgau 27

＜210＞ 1256<210> 1256

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1256<400> 1256

gaaggaacug augagncgaa agcaaca 27gaaggaacug augagncgaa agcaaca 27

＜210＞ 1257<210> 1257

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1257<400> 1257

agaaggacug augagncgaa aagcaac 27agaaggacug augagncgaa aagcaac 27

＜210＞ 1258<210> 1258

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1258<400> 1258

gagaaggcug augagncgaa aaagcaa 27gagaaggcug augagncgaa aaagcaa 27

＜210＞ 1259<210> 1259

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1259<400> 1259

ggagaagcug augagncgaa aaaagca 27ggagaagcug augagncgaa aaaagca 27

＜210＞ 1260<210> 1260

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1260<400> 1260

ccaggagcug augagncgaa aggaaaa 27ccaggagcug augagncgaa aggaaaa 27

＜210＞ 1261<210> 1261

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1261<400> 1261

gccaggacug augagncgaa aaggaaa 27gccaggacug augagncgaa aaggaaa 27

＜210＞ 1262<210> 1262

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1262<400> 1262

ccgccagcug augagncgaa agaagga 27ccgccagcug augagncgaa agaagga 27

＜210＞ 1263<210> 1263

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1263<400> 1263

cauccaccug augagncgaa agcaggc 27cauccaccug augagncgaa agcaggc 27

＜210＞ 1264<210> 1264

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1264<400> 1264

ccugggccug augagncgaa aucagca 27ccugggccug augagncgaa aucagca 27

＜210＞ 1265<210> 1265

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1265<400> 1265

ggccaggcug augagncgaa acgccgc 27ggccaggcug augagncgaa acgccgc 27

＜210＞ 1266<210> 1266

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1266<400> 1266

aggagagcug augagncgaa augccau 27aggagagcug augagncgaa augccau 27

＜210＞ 1267<210> 1267

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1267<400> 1267

aaggagacug augagncgaa aaugcca 27aaggagacug augagncgaa aaugcca 27

＜210＞ 1268<210> 1268

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1268<400> 1268

ggaaggacug augagncgaa agaaugc 27ggaaggacug augagncgaa agaaugc 27

＜210＞ 1269<210> 1269

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1269<400> 1269

aaggaagcug augagncgaa agagaau 27aaggaagcug augagncgaa agagaau 27

＜210＞ 1270<210> 1270

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1270<400> 1270

cacaaggcug augagncgaa aggagag 27cacaaggcug augagncgaa aggagag 27

＜210＞ 1271<210> 1271

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1271<400> 1271

acacaagcug augagncgaa aaggaga 27acacaagcug augagncgaa aaggaga 27

＜210＞ 1272<210> 1272

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1272<400> 1272

aaaacaccug augagncgaa aggaagg 27aaaacaccug augagncgaa aggaagg 27

＜210＞ 1273<210> 1273

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1273<400> 1273

acagaaacug augagncgaa acacaag 27acagaaacug augagncgaa acacaag 27

＜210＞ 1274<210> 1274

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1274<400> 1274

cacagaacug augagncgaa aacacaa 27cacagaacug augagncgaa aacacaa 27

＜210＞ 1275<210> 1275

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1275<400> 1275

gcacagacug augagncgaa aaacaca 27gcacagacug augagncgaa aaacaca 27

＜210＞ 1276<210> 1276

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1276<400> 1276

ggcacagcug augagncgaa aaaacac 27ggcacagcug augagncgaa aaaacac 27

＜210＞ 1277<210> 1277

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1277<400> 1277

cggcacacug augagncgaa aaaaaca 27cggcacacug augagncgaa aaaaaca 27

＜210＞ 1278<210> 1278

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1278<400> 1278

ggagcagcug augagncgaa agcagcg 27ggagcagcug augagncgaa agcagcg 27

＜210＞ 1279<210> 1279

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1279<400> 1279

ugguggucug augagncgaa acgccag 27ugguggucug augagncgaa acgccag 27

＜210＞ 1280<210> 1280

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1280<400> 1280

gugguggcug augagncgaa aacgcca 27gugguggcug augagncgaa aacgcca 27

＜210＞ 1281<210> 1281

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1281<400> 1281

uccacaccug augagncgaa augcagc 27uccacaccug augagncgaa augcagc 27

＜210＞ 1282<210> 1282

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1282<400> 1282

cuacaaacug augagncgaa accaccc 27cuacaaacug augagncgaa accaccc 27

＜210＞ 1283<210> 1283

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1283<400> 1283

ccuacaacug augagncgaa aaccacc 27ccuacaacug augagncgaa aaccacc 27

＜210＞ 1284<210> 1284

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1284<400> 1284

accuacacug augagncgaa aaaccac 27accuacacug augagncgaa aaaccac 27

＜210＞ 1285<210> 1285

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1285<400> 1285

gaccuaccug augagncgaa aaaacca 27gaccuaccug augagncgaa aaaacca 27

＜210＞ 1286<210> 1286

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1286<400> 1286

uuagacccug augagncgaa acaaaaa 27uuagacccug augagncgaa acaaaaa 27

＜210＞ 1287<210> 1287

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1287<400> 1287

aguauuacug augagncgaa accuaca 27aguauuacug augagncgaa accuaca 27

＜210＞ 1288<210> 1288

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1288<400> 1288

agaguaucug augagncgaa agaccua 27agaguaucug augagncgaa agaccua 27

＜210＞ 1289<210> 1289

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1289<400> 1289

ucaagagcug augagncgaa auuagac 27ucaagagcug augagncgaa auuagac 27

＜210＞ 1290<210> 1290

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1290<400> 1290

aggucaacug augagncgaa aguauua 27aggucaacug augagncgaa aguauua 27

＜210＞ 1291<210> 1291

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1291<400> 1291

caagguccug augagncgaa agaguau 27caagguccug augagncgaa agaguau 27

＜210＞ 1292<210> 1292

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1292<400> 1292

uggugaccug augagncgaa aggucaa 27uggugaccug augagncgaa aggucaa 27

＜210＞ 1293<210> 1293

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1293<400> 1293

guguggucug augagncgaa acaaggu 27guguggucug augagncgaa acaaggu 27

＜210＞ 1294<210> 1294

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1294<400> 1294

cacuuugcug augagncgaa agugugg 27cacuuugcug augagncgaa agugugg 27

＜210＞ 1295<210> 1295

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1295<400> 1295

ggcgaggcug augagncgaa acacuuu 27ggcgaggcug augagncgaa acacuuu 27

＜210＞ 1296<210> 1296

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1296<400> 1296

uggcgagcug augagncgaa aacacuu 27uggcgagcug augagncgaa aacacuu 27

＜210＞ 1297<210> 1297

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1297<400> 1297

gccuggccug augagncgaa aggaaca 27gccuggccug augagncgaa aggaaca 27

＜210＞ 1298<210> 1298

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1298<400> 1298

accauaucug augagncgaa agccugg 27accauaucug augagncgaa agccugg 27

＜210＞ 1299<210> 1299

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1299<400> 1299

accaccacug augagncgaa augagcc 27accaccacug augagncgaa augagcc 27

＜210＞ 1300<210> 1300

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1300<400> 1300

cuggugacug augagncgaa aaaguau 27cuggugacug augagncgaa aaaguau 27

＜210＞ 1301<210> 1301

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1301<400> 1301

cccuggucug augagncgaa auaaagu 27cccuggucug augagncgaa auaaagu 27

＜210＞ 1302<210> 1302

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1302<400> 1302

caaagaucug augagncgaa agcucug 27caaagaucug augagncgaa agcucug 27

＜210＞ 1303<210> 1303

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1303<400> 1303

ugucaaacug augagncgaa auuagcu 27ugucaaacug augagncgaa auuagcu 27

＜210＞ 1304<210> 1304

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1304<400> 1304

aaugucacug augagncgaa agauuag 27aaugucacug augagncgaa agauuag 27

＜210＞ 1305<210> 1305

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1305<400> 1305

uaauguccug augagncgaa aagauua 27uaauguccug augagncgaa aagauua 27

＜210＞ 1306<210> 1306

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1306<400> 1306

guuuggucug augagncgaa augucaa 27guuuggucug augagncgaa augucaa 27

＜210＞ 1307<210> 1307

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1307<400> 1307

aguuuggcug augagncgaa aauguca 27aguuuggcug augagncgaa aauguca 27

＜210＞ 1308<210> 1308

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1308<400> 1308

cgagcagcug augagncgaa aguuugg 27cgagcagcug augagncgaa aguuugg 27

＜210＞ 1309<210> 1309

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1309<400> 1309

gaauggccug augagncgaa agcagga 27gaauggccug augagncgaa agcagga 27

＜210＞ 1310<210> 1310

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1310<400> 1310

gaccgagcug augagncgaa auggcga 27gaccgagcug augagncgaa auggcga 27

＜210＞ 1311<210> 1311

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1311<400> 1311

ggaccgacug augagncgaa aauggcg 27ggaccgacug augagncgaa aauggcg 27

＜210＞ 1312<210> 1312

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1312<400> 1312

gcggacccug augagncgaa agaaugg 27gcggacccug augagncgaa agaaugg 27

＜210＞ 1313<210> 1313

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1313<400> 1313

augagcgcug augagncgaa accgaga 27augagcgcug augagncgaa accgaga 27

＜210＞ 1314<210> 1314

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1314<400> 1314

gcaccaucug augagncgaa agcggac 27gcaccaucug augagncgaa agcggac 27

＜210＞ 1315<210> 1315

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1315<400> 1315

cagccugcug augagncgaa agcacca 27cagccugcug augagncgaa agcacca 27

＜210＞ 1316<210> 1316

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1316<400> 1316

uacaaagcug augagncgaa acggcau 27uacaaagcug augagncgaa acggcau 27

＜210＞ 1317<210> 1317

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1317<400> 1317

gcguacacug augagncgaa aguacgg 27gcguacacug augagncgaa aguacgg 27

＜210＞ 1318<210> 1318

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1318<400> 1318

cgcguaccug augagncgaa aaguacg 27cgcguaccug augagncgaa aaguacg 27

＜210＞ 1319<210> 1319

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1319<400> 1319

gagcgcgcug augagncgaa acaaagu 27gagcgcgcug augagncgaa acaaagu 27

＜210＞ 1320<210> 1320

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1320<400> 1320

agccccucug augagncgaa agcgcgu 27agccccucug augagncgaa agcgcgu 27

＜210＞ 1321<210> 1321

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1321<400> 1321

cacgaaucug augagncgaa agccccu 27cacgaaucug augagncgaa agccccu 27

＜210＞ 1322<210> 1322

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1322<400> 1322

gcacgaacug augagncgaa aagcccc 27gcacgaacug augagncgaa aagcccc 27

＜210＞ 1323<210> 1323

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1323<400> 1323

augcacgcug augagncgaa auaagcc 27augcacgcug augagncgaa auaagcc 27

＜210＞ 1324<210> 1324

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1324<400> 1324

caugcaccug augagncgaa aauaagc 27caugcaccug augagncgaa aauaagc 27

＜210＞ 1325<210> 1325

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1325<400> 1325

ccgcacccug augagncgaa acaugca 27ccgcacccug augagncgaa acaugca 27

＜210＞ 1326<210> 1326

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1326<400> 1326

cuccggccug augagncgaa acuuucc 27cuccggccug augagncgaa acuuucc 27

＜210＞ 1327<210> 1327

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1327<400> 1327

acguacgcug augagncgaa accuguc 27acguacgcug augagncgaa accuguc 27

＜210＞ 1328<210> 1328

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1328<400> 1328

auagacgcug augagncgaa acguacc 27auagacgcug augagncgaa acguacc 27

＜210＞ 1329<210> 1329

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1329<400> 1329

ggucauacug augagncgaa acguacg 27ggucauacug augagncgaa acguacg 27

＜210＞ 1330<210> 1330

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1330<400> 1330

auggucacug augagncgaa agacgua 27auggucacug augagncgaa agacgua 27

＜210＞ 1331<210> 1331

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1331<400> 1331

gggguaacug augagncgaa augguca 27gggguaacug augagncgaa augguca 27

＜210＞ 1332<210> 1332

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1332<400> 1332

gcggggucug augagncgaa agauggu 27gcggggucug augagncgaa agauggu 27

＜210＞ 1333<210> 1333

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1333<400> 1333

agcggggcug augagncgaa aagaugg 27agcggggcug augagncgaa aagaugg 27

＜210＞ 1334<210> 1334

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1334<400> 1334

cgggcuccug augagncgaa acugcca 27cgggcuccug augagncgaa acugcca 27

＜210＞ 1335<210> 1335

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1335<400> 1335

ugucagacug augagncgaa aagacga 27ugucagacug augagncgaa aagacga 27

＜210＞ 1336<210> 1336

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1336<400> 1336

caugucacug augagncgaa agaagac 27caugucacug augagncgaa agaagac 27

＜210＞ 1337<210> 1337

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1337<400> 1337

gucccagcug augagncgaa aguaucu 27gucccagcug augagncgaa aguaucu 27

＜210＞ 1338<210> 1338

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1338<400> 1338

ggucccacug augagncgaa aaguauc 27ggucccacug augagncgaa aaguauc 27

＜210＞ 1339<210> 1339

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1339<400> 1339

ucaaugccug augagncgaa aucggcc 27ucaaugccug augagncgaa aucggcc 27

＜210＞ 1340<210> 1340

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1340<400> 1340

gcccuuccug augagncgaa augcuau 27gcccuuccug augagncgaa augcuau 27

＜210＞ 1341<210> 1341

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1341<400> 1341

uugggcgcug augagncgaa aggccgu 27uugggcgcug augagncgaa aggccgu 27

＜210＞ 1342<210> 1342

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1342<400> 1342

aaccaagcug augagncgaa aggcccc 27aaccaagcug augagncgaa aggcccc 27

＜210＞ 1343<210> 1343

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1343<400> 1343

ugcaacccug augagncgaa aguaggc 27ugcaacccug augagncgaa aguaggc 27

＜210＞ 1344<210> 1344

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1344<400> 1344

acaaugccug augagncgaa accaagu 27acaaugccug augagncgaa accaagu 27

＜210＞ 1345<210> 1345

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1345<400> 1345

uaguaaccug augagncgaa augcaac 27uaguaaccug augagncgaa augcaac 27

＜210＞ 1346<210> 1346

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1346<400> 1346

ggcuagucug augagncgaa acaaugc 27ggcuagucug augagncgaa acaaugc 27

＜210＞ 1347<210> 1347

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1347<400> 1347

aggcuagcug augagncgaa aacaaug 27aggcuagcug augagncgaa aacaaug 27

＜210＞ 1348<210> 1348

＜211＞ 27 ＜212＞ RNA<211> 27 <212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1348<400> 1348

gugaggccug augagncgaa aguaaca 27gugaggccug augagncgaa aguaaca 27

＜210＞ 1349<210> 1349

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1349<400> 1349

ccccuuccug augagncgaa accuggu 27ccccuuccug augagncgaa accuggu 27

＜210＞ 1350<210> 1350

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1350<400> 1350

caggaaacug augagncgaa auugugu 27caggaaacug augagncgaa auugugu 27

＜210＞ 1351<210> 1351

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1351<400> 1351

gccaggacug augagncgaa agauugu 27gccaggacug augagncgaa agauugu 27

＜210＞ 1352<210> 1352

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1352<400> 1352

cgccaggcug augagncgaa aagauug 27cgccaggcug augagncgaa aagauug 27

＜210＞ 1353<210> 1353

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1353<400> 1353

ucgccagcug augagncgaa aaagauu 27ucgccagcug augagncgaa aaagauu 27

＜210＞ 1354<210> 1354

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1354<400> 1354

caccauucug augagncgaa acgcagg 27caccauucug augagncgaa acgcagg 27

＜210＞ 1355<210> 1355

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1355<400> 1355

acaccaucug augagncgaa aacgcag 27acaccaucug augagncgaa aacgcag 27

＜210＞ 1356<210> 1356

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1356<400> 1356

cguggaacug augagncgaa acggucc 27cguggaacug augagncgaa acggucc 27

＜210＞ 1357<210> 1357

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1357<400> 1357

gccguggcug augagncgaa agacggu 27gccguggcug augagncgaa agacggu 27

＜210＞ 1358<210> 1358

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1358<400> 1358

cgccgugcug augagncgaa aagacgg 27cgccgugcug augagncgaa aagacgg 27

＜210＞ 1359<210> 1359

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1359<400> 1359

uuugggucug augagncgaa auugggc 27uuugggucug augagncgaa auugggc 27

＜210＞ 1360<210> 1360

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1360<400> 1360

auuagugcug augagncgaa acauuug 27auuagugcug augagncgaa acauuug 27

＜210＞ 1361<210> 1361

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1361<400> 1361

ucuacaucug augagncgaa aguguac 27ucuacaucug augagncgaa aguguac 27

＜210＞ 1362<210> 1362

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1362<400> 1362

cuugguccug augagncgaa acauuag 27cuugguccug augagncgaa acauuag 27

＜210＞ 1363<210> 1363

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1363<400> 1363

agccgaccug augagncgaa aggucuu 27agccgaccug augagncgaa aggucuu 27

＜210＞ 1364<210> 1364

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1364<400> 1364

gccagcccug augagncgaa acgaggu 27gccagcccug augagncgaa acgaggu 27

＜210＞ 1365<210> 1365

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1365<400> 1365

uccgagccug augagncgaa accgcag 27uccgagccug augagncgaa accgcag 27

＜210＞ 1366<210> 1366

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1366<400> 1366

ccggaaucug augagncgaa acgucag 27ccggaaucug augagncgaa acgucag 27

＜210＞ 1367<210> 1367

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1367<400> 1367

aauaggacug augagncgaa acggguc 27aauaggacug augagncgaa acggguc 27

＜210＞ 1368<210> 1368

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1368<400> 1368

caaauagcug augagncgaa agacggg 27caaauagcug augagncgaa agacggg 27

＜210＞ 1369<210> 1369

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1369<400> 1369

cuucaaacug augagncgaa aggagac 27cuucaaacug augagncgaa aggagac 27

＜210＞ 1370<210> 1370

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1370<400> 1370

cccuucacug augagncgaa auaggag 27cccuucacug augagncgaa auaggag 27

＜210＞ 1371<210> 1371

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1371<400> 1371

gcccuuccug augagncgaa aauagga 27gcccuuccug augagncgaa aauagga 27

＜210＞ 1372<210> 1372

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1372<400> 1372

acccgaacug augagncgaa agcccuu 27acccgaacug augagncgaa agcccuu 27

＜210＞ 1373<210> 1373

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1373<400> 1373

ccacccgcug augagncgaa agagccc 27ccacccgcug augagncgaa agagccc 27

＜210＞ 1374<210> 1374

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1374<400> 1374

ggguaugcug augagncgaa aguccac 27ggguaugcug augagncgaa aguccac 27

＜210＞ 1375<210> 1375

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1375<400> 1375

cggguaucug augagncgaa aagucca 27cggguaucug augagncgaa aagucca 27

＜210＞ 1376<210> 1376

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1376<400> 1376

caacgggcug augagncgaa augaagu 27caacgggcug augagncgaa augaagu 27

＜210＞ 1377<210> 1377

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1377<400> 1377

uagacuccug augagncgaa acgggua 27uagacuccug augagncgaa acgggua 27

＜210＞ 1378<210> 1378

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1378<400> 1378

uuccauacug augagncgaa acucaac 27uuccauacug augagncgaa acucaac 27

＜210＞ 1379<210> 1379

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1379<400> 1379

guuuccacug augagncgaa agacuca 27guuuccacug augagncgaa agacuca 27

＜210＞ 1380<210> 1380

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1380<400> 1380

cgcauagcug augagncgaa aguuucc 27cgcauagcug augagncgaa aguuucc 27

＜210＞ 1381<210> 1381

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1381<400> 1381

gaccgcacug augagncgaa aguaguu 27gaccgcacug augagncgaa aguaguu 27

＜210＞ 1382<210> 1382

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1382<400> 1382

gaccgggcug augagncgaa accgcau 27gaccgggcug augagncgaa accgcau 27

＜210＞ 1383<210> 1383

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1383<400> 1383

ccgugaacug augagncgaa accgggg 27ccgugaacug augagncgaa accgggg 27

＜210＞ 1384<210> 1384

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1384<400> 1384

guccgugcug augagncgaa agaccgg 27guccgugcug augagncgaa agaccgg 27

＜210＞ 1385<210> 1385

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1385<400> 1385

uguccgucug augagncgaa aagaccg 27uguccgucug augagncgaa aagaccg 27

＜210＞ 1386<210> 1386

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1386<400> 1386

gggagaucug augagncgaa aguuguc 27gggagaucug augagncgaa aguuguc 27

＜210＞ 1387<210> 1387

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1387<400> 1387

cgggggacug augagncgaa augaguu 27cgggggacug augagncgaa augaguu 27

＜210＞ 1388<210> 1388

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1388<400> 1388

gccggggcug augagncgaa agaugag 27gccggggcug augagncgaa agaugag 27

＜210＞ 1389<210> 1389

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1389<400> 1389

ucugcggcug augagncgaa acggccg 27ucugcggcug augagncgaa acggccg 27

＜210＞ 1390<210> 1390

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1390<400> 1390

cacuuggcug augagncgaa augucug 27cacuuggcug augagncgaa augucug 27

＜210＞ 1391<210> 1391

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1391<400> 1391

ccacuugcug augagncgaa aaugucu 27ccacuugcug augagncgaa aaugucu 27

＜210＞ 1392<210> 1392

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1392<400> 1392

gcguguacug augagncgaa augggcc 27gcguguacug augagncgaa augggcc 27

＜210＞ 1393<210> 1393

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1393<400> 1393

gagcgugcug augagncgaa agauggg 27gagcgugcug augagncgaa agauggg 27

＜210＞ 1394<210> 1394

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1394<400> 1394

ccaguggcug augagncgaa agcgugu 27ccaguggcug augagncgaa agcgugu 27

＜210＞ 1395<210> 1395

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1395<400> 1395

ggacgagcug augagncgaa accuugu 27ggacgagcug augagncgaa accuugu 27

＜210＞ 1396<210> 1396

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1396<400> 1396

ucaggaccug augagncgaa aguaccu 27ucaggaccug augagncgaa aguaccu 27

＜210＞ 1397<210> 1397

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1397<400> 1397

gguucagcug augagncgaa acgagua 27gguucagcug augagncgaa acgagua 27

＜210＞ 1398<210> 1398

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1398<400> 1398

ggcaacacug augagncgaa auggguu 27ggcaacacug augagncgaa auggguu 27

＜210＞ 1399<210> 1399

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1399<400> 1399

aaaaccccug augagncgaa agguggc 27aaaaccccug augagncgaa agguggc 27

＜210＞ 1400<210> 1400

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1400<400> 1400

gccccaacug augagncgaa acccaag 27gccccaacug augagncgaa acccaag 27

＜210＞ 1401<210> 1401

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1401<400> 1401

cgccccacug augagncgaa aacccaa 27cgccccacug augagncgaa aacccaa 27

＜210＞ 1402<210> 1402

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1402<400> 1402

acgcccccug augagncgaa aaaccca 27acgcccccug augagncgaa aaaccca 27

＜210＞ 1403<210> 1403

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1403<400> 1403

agacauacug augagncgaa acgcccc 27agacauacug augagncgaa acgcccc 27

＜210＞ 1404<210> 1404

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1404<400> 1404

uuagacacug augagncgaa auacgcc 27uuagacacug augagncgaa auacgcc 27

＜210＞ 1405<210> 1405

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1405<400> 1405

ugccuuacug augagncgaa acauaua 27ugccuuacug augagncgaa acauaua 27

＜210＞ 1406<210> 1406

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1406<400> 1406

ugugccucug augagncgaa agacaua 27ugugccucug augagncgaa agacaua 27

＜210＞ 1407<210> 1407

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1407<400> 1407

gggucggcug augagncgaa accaugu 27gggucggcug augagncgaa accaugu 27

＜210＞ 1408<210> 1408

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1408<400> 1408

ccguggucug augagncgaa auggucc 27ccguggucug augagncgaa auggucc 27

＜210＞ 1409<210> 1409

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1409<400> 1409

cccguggcug augagncgaa aaugguc 27cccguggcug augagncgaa aaugguc 27

＜210＞ 1410<210> 1410

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1410<400> 1410

aguacgucug augagncgaa auggggg 27aguacgucug augagncgaa auggggg 27

＜210＞ 1411<210> 1411

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1411<400> 1411

gguggagcug augagncgaa acgugau 27gguggagcug augagncgaa acgugau 27

＜210＞ 1412<210> 1412

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1412<400> 1412

auaggugcug augagncgaa aguacgu 27auaggugcug augagncgaa aguacgu 27

＜210＞ 1413<210> 1413

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1413<400> 1413

cccccagcug augagncgaa acaucca 27cccccagcug augagncgaa acaucca 27

＜210＞ 1414<210> 1414

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1414<400> 1414

gcccccacug augagncgaa aacaucc 27gcccccacug augagncgaa aacaucc 27

＜210＞ 1415<210> 1415

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1415<400> 1415

gauaucacug augagncgaa aggcgcc 27gauaucacug augagncgaa aggcgcc 27

＜210＞ 1416<210> 1416

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1416<400> 1416

auuaugacug augagncgaa aucauag 27auuaugacug augagncgaa aucauag 27

＜210＞ 1417<210> 1417

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1417<400> 1417

auauuaucug augagncgaa auaucau 27auauuaucug augagncgaa auaucau 27

＜210＞ 1418<210> 1418

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1418<400> 1418

gucaguucug augagncgaa aguggca 27gucaguucug augagncgaa aguggca 27

＜210＞ 1419<210> 1419

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1419<400> 1419

gguaguccug augagncgaa agucagu 27gguaguccug augagncgaa agucagu 27

＜210＞ 1420<210> 1420

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1420<400> 1420

aggauggcug augagncgaa agucgag 27aggauggcug augagncgaa agucgag 27

＜210＞ 1421<210> 1421

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1421<400> 1421

ugcccagcug augagncgaa augguag 27ugcccagcug augagncgaa augguag 27

＜210＞ 1422<210> 1422

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1422<400> 1422

cugugcccug augagncgaa augccca 27cugugcccug augagncgaa augccca 27

＜210＞ 1423<210> 1423

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1423<400> 1423

ggaggcgcug augagncgaa agcggug 27ggaggcgcug augagncgaa agcggug 27

＜210＞ 1424<210> 1424

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1424<400> 1424

gaucccgcug augagncgaa aggcgua 27gaucccgcug augagncgaa aggcgua 27

＜210＞ 1425<210> 1425

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1425<400> 1425

gguaacccug augagncgaa aucccgg 27gguaacccug augagncgaa aucccgg 27

＜210＞ 1426<210> 1426

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1426<400> 1426

gcacggucug augagncgaa accgauc 27gcacggucug augagncgaa accgauc 27

＜210＞ 1427<210> 1427

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1427<400> 1427

ggcacggcug augagncgaa aaccgau 27ggcacggcug augagncgaa aaccgau 27

＜210＞ 1428<210> 1428

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1428<400> 1428

ccuccuccug augagncgaa auauuug 27ccuccuccug augagncgaa auauuug 27

＜210＞ 1429<210> 1429

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1429<400> 1429

uuggacacug augagncgaa agccacc 27uuggacacug augagncgaa agccacc 27

＜210＞ 1430<210> 1430

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1430<400> 1430

gccauagcug augagncgaa aggggau 27gccauagcug augagncgaa aggggau 27

＜210＞ 1431<210> 1431

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1431<400> 1431

ugccauacug augagncgaa aagggga 27ugccauacug augagncgaa aagggga 27

＜210＞ 1432<210> 1432

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1432<400> 1432

cuugccacug augagncgaa agaaggg 27cuugccacug augagncgaa agaaggg 27

＜210＞ 1433<210> 1433

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1433<400> 1433

aaaaugacug augagncgaa augccuu 27aaaaugacug augagncgaa augccuu 27

＜210＞ 1434<210> 1434

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1434<400> 1434

agaaaaucug augagncgaa agaugcc 27agaaaaucug augagncgaa agaugcc 27

＜210＞ 1435<210> 1435

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1435<400> 1435

ggcagaacug augagncgaa augagau 27ggcagaacug augagncgaa augagau 27

＜210＞ 1436<210> 1436

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1436<400> 1436

uggcagacug augagncgaa aaugaga 27uggcagacug augagncgaa aaugaga 27

＜210＞ 1437<210> 1437

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1437<400> 1437

guggcagcug augagncgaa aaaugag 27guggcagcug augagncgaa aaaugag 27

＜210＞ 1438<210> 1438

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1438<400> 1438

aguggcacug augagncgaa aaaauga 27aguggcacug augagncgaa aaaauga 27

＜210＞ 1439<210> 1439

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1439<400> 1439

uugcggccug augagncgaa agcucau 27uugcggccug augagncgaa agcucau 27

＜210＞ 1440<210> 1440

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1440<400> 1440

gaggccucug augagncgaa acagcuu 27gaggccucug augagncgaa acagcuu 27

＜210＞ 1441<210> 1441

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1441<400> 1441

ugauucccug augagncgaa aggccug 27ugauucccug augagncgaa aggccug 27

＜210＞ 1442<210> 1442

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1442<400> 1442

acgucaacug augagncgaa accccgg 27acgucaacug augagncgaa accccgg 27

＜210＞ 1443<210> 1443

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1443<400> 1443

acacguccug augagncgaa agacccc 27acacguccug augagncgaa agacccc 27

＜210＞ 1444<210> 1444

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1444<400> 1444

uaugacgcug augagncgaa acacguc 27uaugacgcug augagncgaa acacguc 27

＜210＞ 1445<210> 1445

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1445<400> 1445

cgauaaccug augagncgaa acaucuc 27cgauaaccug augagncgaa acaucuc 27

＜210＞ 1446<210> 1446

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1446<400> 1446

ccacgaucug augagncgaa acgacau 27ccacgaucug augagncgaa acgacau 27

＜210＞ 1447<210> 1447

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1447<400> 1447

gccacgacug augagncgaa aacgaca 27gccacgacug augagncgaa aacgaca 27

＜210＞ 1448<210> 1448

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1448<400> 1448

uugccaccug augagncgaa auaacga 27uugccaccug augagncgaa auaacga 27

＜210＞ 1449<210> 1449

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1449<400> 1449

gucauuacug augagncgaa agcgucu 27gucauuacug augagncgaa agcgucu 27

＜210＞ 1450<210> 1450

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1450<400> 1450

ccgucaucug augagncgaa agagcgu 27ccgucaucug augagncgaa agagcgu 27

＜210＞ 1451<210> 1451

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1451<400> 1451

cgagucacug augagncgaa agucacc 27cgagucacug augagncgaa agucacc 27

＜210＞ 1452<210> 1452

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1452<400> 1452

ccgaguccug augagncgaa aagucac 27ccgaguccug augagncgaa aagucac 27

＜210＞ 1453<210> 1453

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1453<400> 1453

gaucacccug augagncgaa agucaaa 27gaucacccug augagncgaa agucaaa 27

＜210＞ 1454<210> 1454

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1454<400> 1454

ucugggucug augagncgaa acacaug 27ucugggucug augagncgaa acacaug 27

＜210＞ 1455<210> 1455

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1455<400> 1455

ugaaauccug augagncgaa acugucu 27ugaaauccug augagncgaa acugucu 27

＜210＞ 1456<210> 1456

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1456<400> 1456

aagcugacug augagncgaa aucgacu 27aagcugacug augagncgaa aucgacu 27

＜210＞ 1457<210> 1457

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1457<400> 1457

caagcugcug augagncgaa aaucgac 27caagcugcug augagncgaa aaucgac 27

＜210＞ 1458<210> 1458

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1458<400> 1458

ccaagcucug augagncgaa aaaucga 27ccaagcucug augagncgaa aaaucga 27

＜210＞ 1459<210> 1459

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1459<400> 1459

gggaucccug augagncgaa agcugaa 27gggaucccug augagncgaa agcugaa 27

＜210＞ 1460<210> 1460

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1460<400> 1460

aagguggcug augagncgaa auccaag 27aagguggcug augagncgaa auccaag 27

＜210＞ 1461<210> 1461

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1461<400> 1461

aaugguacug augagncgaa agguggg 27aaugguacug augagncgaa agguggg 27

＜210＞ 1462<210> 1462

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1462<400> 1462

caauggucug augagncgaa aaggugg 27caauggucug augagncgaa aaggugg 27

＜210＞ 1463<210> 1463

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1463<400> 1463

ucaauggcug augagncgaa aaaggug 27ucaauggcug augagncgaa aaaggug 27

＜210＞ 1464<210> 1464

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1464<400> 1464

ucgucuccug augagncgaa augguaa 27ucgucuccug augagncgaa augguaa 27

＜210＞ 1465<210> 1465

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1465<400> 1465

ccucccccug augagncgaa accccug 27ccucccccug augagncgaa accccug 27

＜210＞ 1466<210> 1466

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1466<400> 1466

accuguacug augagncgaa augccuc 27accuguacug augagncgaa augccuc 27

＜210＞ 1467<210> 1467

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1467<400> 1467

aaaccugcug augagncgaa agaugcc 27aaaccugcug augagncgaa agaugcc 27

＜210＞ 1468<210> 1468

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1468<400> 1468

agucacacug augagncgaa accugua 27agucacacug augagncgaa accugua 27

＜210＞ 1469<210> 1469

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1469<400> 1469

gagucaccug augagncgaa aaccugu 27gagucaccug augagncgaa aaccugu 27

＜210＞ 1470<210> 1470

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1470<400> 1470

ucucccgcug augagncgaa agucaca 27ucucccgcug augagncgaa agucaca 27

＜210＞ 1471<210> 1471

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1471<400> 1471

caugccccug augagncgaa agggccg 27caugccccug augagncgaa agggccg 27

＜210＞ 1472<210> 1472

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1472<400> 1472

agaaucgcug augagncgaa acaugcc 27agaaucgcug augagncgaa acaugcc 27

＜210＞ 1473<210> 1473

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1473<400> 1473

aagaauccug augagncgaa aacaugc 27aagaauccug augagncgaa aacaugc 27

＜210＞ 1474<210> 1474

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1474<400> 1474

accgaagcug augagncgaa aucgaac 27accgaagcug augagncgaa aucgaac 27

＜210＞ 1475<210> 1475

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1475<400> 1475

gaccgaacug augagncgaa aaucgaa 27gaccgaacug augagncgaa aaucgaa 27

＜210＞ 1476<210> 1476

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1476<400> 1476

aggaccgcug augagncgaa agaaucg 27aggaccgcug augagncgaa agaaucg 27

＜210＞ 1477<210> 1477

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1477<400> 1477

caggacccug augagncgaa aagaauc 27caggacccug augagncgaa aagaauc 27

＜210＞ 1478<210> 1478

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1478<400> 1478

cacacagcug augagncgaa accgaag 27cacacagcug augagncgaa accgaag 27

＜210＞ 1479<210> 1479

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1479<400> 1479

cgcgucacug augagncgaa agcacuc 27cgcgucacug augagncgaa agcacuc 27

＜210＞ 1480<210> 1480

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1480<400> 1480

uucccagcug augagncgaa acuccag 27uucccagcug augagncgaa acuccag 27

＜210＞ 1481<210> 1481

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1481<400> 1481

uuucccacug augagncgaa aacucca 27uuucccacug augagncgaa aacucca 27

＜210＞ 1482<210> 1482

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1482<400> 1482

cugugaacug augagncgaa acgcuuu 27cugugaacug augagncgaa acgcuuu 27

＜210＞ 1483<210> 1483

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1483<400> 1483

gccugugcug augagncgaa agacgcu 27gccugugcug augagncgaa agacgcu 27

＜210＞ 1484<210> 1484

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1484<400> 1484

ggccugucug augagncgaa aagacgc 27ggccugucug augagncgaa aagacgc 27

＜210＞ 1485<210> 1485

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1485<400> 1485

ugugggucug augagncgaa aggccug 27ugugggucug augagncgaa aggccug 27

＜210＞ 1486<210> 1486

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1486<400> 1486

gggcauccug augagncgaa auguggg 27gggcauccug augagncgaa auguggg 27

＜210＞ 1487<210> 1487

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1487<400> 1487

ggacaggcug augagncgaa agugggc 27ggacaggcug augagncgaa agugggc 27

＜210＞ 1488<210> 1488

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1488<400> 1488

gggacagcug augagncgaa aaguggg 27gggacagcug augagncgaa aaguggg 27

＜210＞ 1489<210> 1489

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1489<400> 1489

gguuuggcug augagncgaa acaggaa 27gguuuggcug augagncgaa acaggaa 27

＜210＞ 1490<210> 1490

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1490<400> 1490

guaagggcug augagncgaa aguuguc 27guaagggcug augagncgaa aguuguc 27

＜210＞ 1491<210> 1491

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1491<400> 1491

gguaaggcug augagncgaa aaguugu 27gguaaggcug augagncgaa aaguugu 27

＜210＞ 1492<210> 1492

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1492<400> 1492

accaggucug augagncgaa agggaag 27accaggucug augagncgaa agggaag 27

＜210＞ 1493<210> 1493

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1493<400> 1493

uaccaggcug augagncgaa aagggaa 27uaccaggcug augagncgaa aagggaa 27

＜210＞ 1494<210> 1494

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1494<400> 1494

ggaggugcug augagncgaa agccuga 27ggaggugcug augagncgaa agccuga 27

＜210＞ 1495<210> 1495

＜211＞ 27<211> 27

＜212＞ RNA ＜213＞ Artificial Sequence<212> RNA <213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1495<400> 1495

cacgaugcug augagncgaa aggugga 27cacgaugcug augagncgaa aggugga 27

＜210＞ 1496<210> 1496

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1496<400> 1496

aucccaccug augagncgaa auggagg 27aucccaccug augagncgaa auggagg 27

＜210＞ 1497<210> 1497

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1497<400> 1497

cacauuucug augagncgaa aucccac 27cacauuucug augagncgaa aucccac 27

＜210＞ 1498<210> 1498

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1498<400> 1498

cguaugacug augagncgaa acacuuc 27cguaugacug augagncgaa acacuuc 27

＜210＞ 1499<210> 1499

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1499<400> 1499

gccguaucug augagncgaa agacacu 27gccguaucug augagncgaa agacacu 27

＜210＞ 1500<210> 1500

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1500<400> 1500

uaagccgcug augagncgaa augagac 27uaagccgcug augagncgaa augagac 27

＜210＞ 1501<210> 1501

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1501<400> 1501

uagguuucug augagncgaa agccgua 27uagguuucug augagncgaa agccgua 27

＜210＞ 1502<210> 1502

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1502<400> 1502

guagguucug augagncgaa aagccgu 27guagguucug augagncgaa aagccgu 27

＜210＞ 1503<210> 1503

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1503<400> 1503

ugcagcgcug augagncgaa agguuua 27ugcagcgcug augagncgaa agguuua 27

＜210＞ 1504<210> 1504

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1504<400> 1504

cggcucccug augagncgaa agccuau 27cggcucccug augagncgaa agccuau 27

＜210＞ 1505<210> 1505

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1505<400> 1505

cauuuugcug augagncgaa acggcuc 27cauuuugcug augagncgaa acggcuc 27

＜210＞ 1506<210> 1506

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1506<400> 1506

ucauuuucug augagncgaa aacggcu 27ucauuuucug augagncgaa aacggcu 27

＜210＞ 1507<210> 1507

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1507<400> 1507

ugagggucug augagncgaa aucucau 27ugagggucug augagncgaa aucucau 27

＜210＞ 1508<210> 1508

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1508<400> 1508

gaugugucug augagncgaa aggguga 27gaugugucug augagncgaa aggguga 27

＜210＞ 1509<210> 1509

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1509<400> 1509

guuauggcug augagncgaa augugug 27guuauggcug augagncgaa augugug 27

＜210＞ 1510<210> 1510

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1510<400> 1510

auuuggucug augagncgaa augggau 27auuuggucug augagncgaa augggau 27

＜210＞ 1511<210> 1511

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1511<400> 1511

caugaugcug augagncgaa auuuggu 27caugaugcug augagncgaa auuuggu 27

＜210＞ 1512<210> 1512

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1512<400> 1512

ccaugaucug augagncgaa aauuugg 27ccaugaucug augagncgaa aauuugg 27

＜210＞ 1513<210> 1513

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1513<400> 1513

augccaucug augagncgaa augaauu 27augccaucug augagncgaa augaauu 27

＜210＞ 1514<210> 1514

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1514<400> 1514

gucggcccug augagncgaa acaugca 27gucggcccug augagncgaa acaugca 27

＜210＞ 1515<210> 1515

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1515<400> 1515

gcggccacug augagncgaa agcugca 27gcggccacug augagncgaa agcugca 27

＜210＞ 1516<210> 1516

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1516<400> 1516

ccacaaucug augagncgaa accacac 27ccacaaucug augagncgaa accacac 27

＜210＞ 1517<210> 1517

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1517<400> 1517

uacccaccug augagncgaa augacca 27uacccaccug augagncgaa augacca 27

＜210＞ 1518<210> 1518

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1518<400> 1518

augaucccug augagncgaa acccaca 27augaucccug augagncgaa acccaca 27

＜210＞ 1519<210> 1519

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1519<400> 1519

cggacaacug augagncgaa augaucc 27cggacaacug augagncgaa augaucc 27

＜210＞ 1520<210> 1520

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1520<400> 1520

ccggacacug augagncgaa aaugauc 27ccggacacug augagncgaa aaugauc 27

＜210＞ 1521<210> 1521

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1521<400> 1521

cccggaccug augagncgaa aaaugau 27cccggaccug augagncgaa aaaugau 27

＜210＞ 1522<210> 1522

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1522<400> 1522

ccucccgcug augagncgaa acaaaau 27ccucccgcug augagncgaa acaaaau 27

＜210＞ 1523<210> 1523

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1523<400> 1523

gguagagcug augagncgaa acuuccc 27gguagagcug augagncgaa acuuccc 27

＜210＞ 1524<210> 1524

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1524<400> 1524

cccgguacug augagncgaa aggacuu 27cccgguacug augagncgaa aggacuu 27

＜210＞ 1525<210> 1525

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1525<400> 1525

cucccggcug augagncgaa agaggac 27cucccggcug augagncgaa agaggac 27

＜210＞ 1526<210> 1526

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1526<400> 1526

uucaucgcug augagncgaa acucccg 27uucaucgcug augagncgaa acucccg 27

＜210＞ 1527<210> 1527

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1527<400> 1527

uuucauccug augagncgaa aacuccc 27uuucauccug augagncgaa aacuccc 27

＜210＞ 1528<210> 1528

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1528<400> 1528

gaggugucug augagncgaa aggcgca 27gaggugucug augagncgaa aggcgca 27

＜210＞ 1529<210> 1529

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1529<400> 1529

uguaaggcug augagncgaa aggugug 27uguaaggcug augagncgaa aggugug 27

＜210＞ 1530<210> 1530

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1530<400> 1530

ucgaugucug augagncgaa agggagg 27ucgaugucug augagncgaa agggagg 27

＜210＞ 1531<210> 1531

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1531<400> 1531

uucgaugcug augagncgaa aagggag 27uucgaugcug augagncgaa aagggag 27

＜210＞ 1532<210> 1532

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1532<400> 1532

ccuguuccug augagncgaa auguaag 27ccuguuccug augagncgaa auguaag 27

＜210＞ 1533<210> 1533

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1533<400> 1533

gcucggccug augagncgaa agcugca 27gcucggccug augagncgaa agcugca 27

＜210＞ 1534<210> 1534

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1534<400> 1534

gcaaccccug augagncgaa agugccu 27gcaaccccug augagncgaa agugccu 27

＜210＞ 1535<210> 1535

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1535<400> 1535

uugcagccug augagncgaa acccgag 27uugcagccug augagncgaa acccgag 27

＜210＞ 1536<210> 1536

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1536<400> 1536

gcugaugcug augagncgaa aguucca 27gcugaugcug augagncgaa aguucca 27

＜210＞ 1537<210> 1537

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1537<400> 1537

cgcugaucug augagncgaa aaguucc 27cgcugaucug augagncgaa aaguucc 27

＜210＞ 1538<210> 1538

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1538<400> 1538

ucccgcucug augagncgaa augaagu 27ucccgcucug augagncgaa augaagu 27

＜210＞ 1539<210> 1539

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1539<400> 1539

aauacugcug augagncgaa aucccgc 27aauacugcug augagncgaa aucccgc 27

＜210＞ 1540<210> 1540

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1540<400> 1540

ugcuaaacug augagncgaa acuguau 27ugcuaaacug augagncgaa acuguau 27

＜210＞ 1541<210> 1541

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1541<400> 1541

ccugcuacug augagncgaa auacugu 27ccugcuacug augagncgaa auacugu 27

＜210＞ 1542<210> 1542

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1542<400> 1542

gccugcucug augagncgaa aauacug 27gccugcucug augagncgaa aauacug 27

＜210＞ 1543<210> 1543

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1543<400> 1543

agccugccug augagncgaa aaauacu 27agccugccug augagncgaa aaauacu 27

＜210＞ 1544<210> 1544

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1544<400> 1544

cagagugcug augagncgaa auaagcc 27cagagugcug augagncgaa auaagcc 27

＜210＞ 1545<210> 1545

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1545<400> 1545

ccaggcacug augagncgaa aguggau 27ccaggcacug augagncgaa aguggau 27

＜210＞ 1546<210> 1546

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1546<400> 1546

gugaugccug augagncgaa aucgcgg 27gugaugccug augagncgaa aucgcgg 27

＜210＞ 1547<210> 1547

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1547<400> 1547

caucagucug augagncgaa augcuau 27caucagucug augagncgaa augcuau 27

＜210＞ 1548<210> 1548

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1548<400> 1548

ggcugugcug augagncgaa augccau 27ggcugugcug augagncgaa augccau 27

＜210＞ 1549<210> 1549

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1549<400> 1549

aggcugucug augagncgaa aaugcca 27aggcugucug augagncgaa aaugcca 27

＜210＞ 1550<210> 1550

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1550<400> 1550

ggugauacug augagncgaa aggcugu 27ggugauacug augagncgaa aggcugu 27

＜210＞ 1551<210> 1551

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1551<400> 1551

cuggugacug augagncgaa agaggcu 27cuggugacug augagncgaa agaggcu 27

＜210＞ 1552<210> 1552

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1552<400> 1552

gacuggucug augagncgaa auagagg 27gacuggucug augagncgaa auagagg 27

＜210＞ 1553<210> 1553

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1553<400> 1553

gugagcgcug augagncgaa acuggug 27gugagcgcug augagncgaa acuggug 27

＜210＞ 1554<210> 1554

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1554<400> 1554

ggguggucug augagncgaa agcggac 27ggguggucug augagncgaa agcggac 27

＜210＞ 1555<210> 1555

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1555<400> 1555

aggagggcug augagncgaa auucugg 27aggagggcug augagncgaa auucugg 27

＜210＞ 1556<210> 1556

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1556<400> 1556

ugaacagcug augagncgaa aggguau 27ugaacagcug augagncgaa aggguau 27

＜210＞ 1557<210> 1557

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1557<400> 1557

ccccuaacug augagncgaa auguuga 27ccccuaacug augagncgaa auguuga 27

＜210＞ 1558<210> 1558

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1558<400> 1558

ucccccucug augagncgaa agauguu 27ucccccucug augagncgaa agauguu 27

＜210＞ 1559<210> 1559

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1559<400> 1559

auccccccug augagncgaa aagaugu 27auccccccug augagncgaa aagaugu 27

＜210＞ 1560<210> 1560

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1560<400> 1560

gcgaguucug augagncgaa agcagcc 27gcgaguucug augagncgaa agcagcc 27

＜210＞ 1561<210> 1561

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1561<400> 1561

gcacuggcug augagncgaa aggagcg 27gcacuggcug augagncgaa aggagcg 27

＜210＞ 1562<210> 1562

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1562<400> 1562

aaggccgcug augagncgaa agcagca 27aaggccgcug augagncgaa agcagca 27

＜210＞ 1563<210> 1563

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1563<400> 1563

uguccaccug augagncgaa agcaccu 27uguccaccug augagncgaa agcaccu 27

＜210＞ 1564<210> 1564

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1564<400> 1564

ccgccagcug augagncgaa augucca 27ccgccagcug augagncgaa augucca 27

＜210＞ 1565<210> 1565

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1565<400> 1565

cccgccacug augagncgaa aaugucc 27cccgccacug augagncgaa aaugucc 27

＜210＞ 1566<210> 1566

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1566<400> 1566

agggagccug augagncgaa aguuaac 27agggagccug augagncgaa aguuaac 27

＜210＞ 1567<210> 1567

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1567<400> 1567

gggagagcug augagncgaa auggcag 27gggagagcug augagncgaa auggcag 27

＜210＞ 1568<210> 1568

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1568<400> 1568

cgggggacug augagncgaa aggaugg 27cgggggacug augagncgaa aggaugg 27

＜210＞ 1569<210> 1569

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1569<400> 1569

cgaacgccug augagncgaa aucagcc 27cgaacgccug augagncgaa aucagcc 27

＜210＞ 1570<210> 1570

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1570<400> 1570

accccgccug augagncgaa aagcgaa 27accccgccug augagncgaa aagcgaa 27

＜210＞ 1571<210> 1571

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1571<400> 1571

acguggucug augagncgaa accccgc 27acguggucug augagncgaa accccgc 27

＜210＞ 1572<210> 1572

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1572<400> 1572

ugggggacug augagncgaa acguggu 27ugggggacug augagncgaa acguggu 27

＜210＞ 1573<210> 1573

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1573<400> 1573

gugggggcug augagncgaa aacgugg 27gugggggcug augagncgaa aacgugg 27

＜210＞ 1574<210> 1574

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1574<400> 1574

cguggggcug augagncgaa aaacgug 27cguggggcug augagncgaa aaacgug 27

＜210＞ 1575<210> 1575

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1575<400> 1575

aggcacgcug augagncgaa agugcgu 27aggcacgcug augagncgaa agugcgu 27

＜210＞ 1576<210> 1576

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1576<400> 1576

ucugagucug augagncgaa acacgug 27ucugagucug augagncgaa acacgug 27

＜210＞ 1577<210> 1577

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1577<400> 1577

aggaucucug augagncgaa aguuaca 27aggaucucug augagncgaa aguuaca 27

＜210＞ 1578<210> 1578

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1578<400> 1578

uggagagcug augagncgaa aucugag 27uggagagcug augagncgaa aucugag 27

＜210＞ 1579<210> 1579

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1579<400> 1579

ggcuggacug augagncgaa aggaucu 27ggcuggacug augagncgaa aggaucu 27

＜210＞ 1580<210> 1580

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1580<400> 1580

gaggcugcug augagncgaa agaggau 27gaggcugcug augagncgaa agaggau 27

＜210＞ 1581<210> 1581

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1581<400> 1581

ugauggucug augagncgaa aggcugg 27ugauggucug augagncgaa aggcugg 27

＜210＞ 1582<210> 1582

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1582<400> 1582

gcugagucug augagncgaa augguga 27gcugagucug augagncgaa augguga 27

＜210＞ 1583<210> 1583

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1583<400> 1583

agcagcucug augagncgaa agugaug 27agcagcucug augagncgaa agugaug 27

＜210＞ 1584<210> 1584

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1584<400> 1584

acuggugcug augagncgaa agccucu 27acuggugcug augagncgaa agccucu 27

＜210＞ 1585<210> 1585

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1585<400> 1585

cacuggucug augagncgaa aagccuc 27cacuggucug augagncgaa aagccuc 27

＜210＞ 1586<210> 1586

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1586<400> 1586

ccucauucug augagncgaa auccacu 27ccucauucug augagncgaa auccacu 27

＜210＞ 1587<210> 1587

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1587<400> 1587

uccucaucug augagncgaa aauccac 27uccucaucug augagncgaa aauccac 27

＜210＞ 1588<210> 1588

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1588<400> 1588

uggcgugcug augagncgaa agcaguc 27uggcgugcug augagncgaa agcaguc 27

＜210＞ 1589<210> 1589

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1589<400> 1589

cgagccgcug augagncgaa agcaugg 27cgagccgcug augagncgaa agcaugg 27

＜210＞ 1590<210> 1590

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1590<400> 1590

uagccaccug augagncgaa agccgga 27uagccaccug augagncgaa agccgga 27

＜210＞ 1591<210> 1591

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1591<400> 1591

cauccuucug augagncgaa agccacg 27cauccuucug augagncgaa agccacg 27

＜210＞ 1592<210> 1592

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1592<400> 1592

agucccacug augagncgaa acauccu 27agucccacug augagncgaa acauccu 27

＜210＞ 1593<210> 1593

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1593<400> 1593

caguccccug augagncgaa aacaucc 27caguccccug augagncgaa aacaucc 27

＜210＞ 1594<210> 1594

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1594<400> 1594

ccgugcacug augagncgaa auccagu 27ccgugcacug augagncgaa auccagu 27

＜210＞ 1595<210> 1595

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1595<400> 1595

gucaguccug augagncgaa acaccgu 27gucaguccug augagncgaa acaccgu 27

＜210＞ 1596<210> 1596

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1596<400> 1596

ggucuugcug augagncgaa agucagu 27ggucuugcug augagncgaa agucagu 27

＜210＞ 1597<210> 1597

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1597<400> 1597

aggucuucug augagncgaa aagucag 27aggucuucug augagncgaa aagucag 27

＜210＞ 1598<210> 1598

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1598<400> 1598

uggacugcug augagncgaa agccagg 27uggacugcug augagncgaa agccagg 27

＜210＞ 1599<210> 1599

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1599<400> 1599

gagcuugcug augagncgaa acuggag 27gagcuugcug augagncgaa acuggag 27

＜210＞ 1600<210> 1600

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1600<400> 1600

ucggcagcug augagncgaa agcuugg 27ucggcagcug augagncgaa agcuugg 27

＜210＞ 1601<210> 1601

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1601<400> 1601

ucccggccug augagncgaa auuucgg 27ucccggccug augagncgaa auuucgg 27

＜210＞ 1602<210> 1602

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1602<400> 1602

agaaaggcug augagncgaa acucccg 27agaaaggcug augagncgaa acucccg 27

＜210＞ 1603<210> 1603

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1603<400> 1603

gagaagacug augagncgaa agggacu 27gagaagacug augagncgaa agggacu 27

＜210＞ 1604<210> 1604

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1604<400> 1604

ugagaagcug augagncgaa aagggac 27ugagaagcug augagncgaa aagggac 27

＜210＞ 1605<210> 1605

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1605<400> 1605

augagaacug augagncgaa aaaggga 27augagaacug augagncgaa aaaggga 27

＜210＞ 1606<210> 1606

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1606<400> 1606

gcaugagcug augagncgaa agaaagg 27gcaugagcug augagncgaa agaaagg 27

＜210＞ 1607<210> 1607

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1607<400> 1607

ggcaugacug augagncgaa aagaaag 27ggcaugacug augagncgaa aagaaag 27

＜210＞ 1608<210> 1608

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1608<400> 1608

uuggcaucug augagncgaa agaagaa 27uuggcaucug augagncgaa agaagaa 27

＜210＞ 1609<210> 1609

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1609<400> 1609

ucccuugcug augagncgaa acccgcg 27ucccuugcug augagncgaa acccgcg 27

＜210＞ 1610<210> 1610

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1610<400> 1610

cccgccacug augagncgaa acucccu 27cccgccacug augagncgaa acucccu 27

＜210＞ 1611<210> 1611

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1611<400> 1611

guccggucug augagncgaa auuugug 27guccggucug augagncgaa auuugug 27

＜210＞ 1612<210> 1612

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1612<400> 1612

uguccggcug augagncgaa aauuugu 27uguccggcug augagncgaa aauuugu 27

＜210＞ 1613<210> 1613

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1613<400> 1613

cguuuuucug augagncgaa acauguc 27cguuuuucug augagncgaa acauguc 27

＜210＞ 1614<210> 1614

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1614<400> 1614

cucauggcug augagncgaa accguuu 27cucauggcug augagncgaa accguuu 27

＜210＞ 1615<210> 1615

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1615<400> 1615

ccucaugcug augagncgaa aaccguu 27ccucaugcug augagncgaa aaccguu 27

＜210＞ 1616<210> 1616

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1616<400> 1616

gcccaaccug augagncgaa auccuca 27gcccaaccug augagncgaa auccuca 27

＜210＞ 1617<210> 1617

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1617<400> 1617

uaggccccug augagncgaa acgaucc 27uaggccccug augagncgaa acgaucc 27

＜210＞ 1618<210> 1618

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1618<400> 1618

cagguuucug augagncgaa aggccca 27cagguuucug augagncgaa aggccca 27

＜210＞ 1619<210> 1619

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1619<400> 1619

gauggggcug augagncgaa acguucc 27gauggggcug augagncgaa acguucc 27

＜210＞ 1620<210> 1620

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1620<400> 1620

ugaugggcug augagncgaa aacguuc 27ugaugggcug augagncgaa aacguuc 27

＜210＞ 1621<210> 1621

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1621<400> 1621

acgcguucug augagncgaa augggga 27acgcguucug augagncgaa augggga 27

＜210＞ 1622<210> 1622

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1622<400> 1622

uguggugcug augagncgaa acgcguu 27uguggugcug augagncgaa acgcguu 27

＜210＞ 1623<210> 1623

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1623<400> 1623

cgccgggcug augagncgaa agggugu 27cgccgggcug augagncgaa agggugu 27

＜210＞ 1624<210> 1624

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1624<400> 1624

cuccacgcug augagncgaa acucuuc 27cuccacgcug augagncgaa acucuuc 27

＜210＞ 1625<210> 1625

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1625<400> 1625

cccgcgucug augagncgaa aucucca 27cccgcgucug augagncgaa aucucca 27

＜210＞ 1626<210> 1626

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1626<400> 1626

acccgcgcug augagncgaa aaucucc 27acccgcgcug augagncgaa aaucucc 27

＜210＞ 1627<210> 1627

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1627<400> 1627

guggucacug augagncgaa acccguc 27guggucacug augagncgaa acccguc 27

＜210＞ 1628<210> 1628

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1628<400> 1628

gggccggcug augagncgaa accuggc 27gggccggcug augagncgaa accuggc 27

＜210＞ 1629<210> 1629

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1629<400> 1629

gaccuggcug augagncgaa augugac 27gaccuggcug augagncgaa augugac 27

＜210＞ 1630<210> 1630

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1630<400> 1630

uggaagucug augagncgaa agcacug 27uggaagucug augagncgaa agcacug 27

＜210＞ 1631<210> 1631

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1631<400> 1631

agcauggcug augagncgaa agugagc 27agcauggcug augagncgaa agugagc 27

＜210＞ 1632<210> 1632

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1632<400> 1632

gagcaugcug augagncgaa aagugag 27gagcaugcug augagncgaa aagugag 27

＜210＞ 1633<210> 1633

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1633<400> 1633

ggucggucug augagncgaa agcaugg 27ggucggucug augagncgaa agcaugg 27

＜210＞ 1634<210> 1634

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1634<400> 1634

aauguggcug augagncgaa agggguc 27aauguggcug augagncgaa agggguc 27

＜210＞ 1635<210> 1635

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1635<400> 1635

cugcugucug augagncgaa auguggg 27cugcugucug augagncgaa auguggg 27

＜210＞ 1636<210> 1636

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1636<400> 1636

ucugcugcug augagncgaa aaugugg 27ucugcugcug augagncgaa aaugugg 27

＜210＞ 1637<210> 1637

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1637<400> 1637

cuacguucug augagncgaa agccguc 27cuacguucug augagncgaa agccguc 27

＜210＞ 1638<210> 1638

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1638<400> 1638

cuagcugcug augagncgaa agagcug 27cuagcugcug augagncgaa agagcug 27

＜210＞ 1639<210> 1639

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1639<400> 1639

gcuagcucug augagncgaa aagagcu 27gcuagcucug augagncgaa aagagcu 27

＜210＞ 1640<210> 1640

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1640<400> 1640

aauuggccug augagncgaa agcugaa 27aauuggccug augagncgaa agcugaa 27

＜210＞ 1641<210> 1641

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1641<400> 1641

uucaaggcug augagncgaa aggcgca 27uucaaggcug augagncgaa aggcgca 27

＜210＞ 1642<210> 1642

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ ArtificialSequence<213> ArtificialSequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1642<400> 1642

cuucaagcug augagncgaa aaggcgc 27cuucaagcug augagncgaa aaggcgc 27

＜210＞ 1643<210> 1643

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1643<400> 1643

ugccuuccug augagncgaa aggaagg 27ugccuuccug augagncgaa aggaagg 27

＜210＞ 1644<210> 1644

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1644<400> 1644

uggugggcug augagncgaa agugcau 27uggugggcug augagncgaa agugcau 27

＜210＞ 1645<210> 1645

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1645<400> 1645

guccgggcug augagncgaa agucaug 27guccgggcug augagncgaa agucaug 27

＜210＞ 1646<210> 1646

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1646<400> 1646

ccucgaucug augagncgaa aggucag 27ccucgaucug augagncgaa aggucag 27

＜210＞ 1647<210> 1647

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1647<400> 1647

uggccuccug augagncgaa augaggu 27uggccuccug augagncgaa augaggu 27

＜210＞ 1648<210> 1648

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1648<400> 1648

cacgggucug augagncgaa auguuuc 27cacgggucug augagncgaa auguuuc 27

＜210＞ 1649<210> 1649

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1649<400> 1649

auucucucug augagncgaa acuccac 27auucucucug augagncgaa acuccac 27

＜210＞ 1650<210> 1650

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1650<400> 1650

accaccucug augagncgaa auucucu 27accaccucug augagncgaa auucucu 27

＜210＞ 1651<210> 1651

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1651<400> 1651

ccaaaaucug augagncgaa accaccu 27ccaaaaucug augagncgaa accaccu 27

＜210＞ 1652<210> 1652

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1652<400> 1652

aguccaacug augagncgaa auuacca 27aguccaacug augagncgaa auuacca 27

＜210＞ 1653<210> 1653

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1653<400> 1653

gaguccacug augagncgaa aauuacc 27gaguccacug augagncgaa aauuacc 27

＜210＞ 1654<210> 1654

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1654<400> 1654

agagucccug augagncgaa aaauuac 27agagucccug augagncgaa aaauuac 27

＜210＞ 1655<210> 1655

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1655<400> 1655

gucgaaacug augagncgaa aguccaa 27gucgaaacug augagncgaa aguccaa 27

＜210＞ 1656<210> 1656

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1656<400> 1656

gggucgacug augagncgaa agagucc 27gggucgacug augagncgaa agagucc 27

＜210＞ 1657<210> 1657

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1657<400> 1657

cgggucgcug augagncgaa aagaguc 27cgggucgcug augagncgaa aagaguc 27

＜210＞ 1658<210> 1658

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1658<400> 1658

gcggguccug augagncgaa aaagagu 27gcggguccug augagncgaa aaagagu 27

＜210＞ 1659<210> 1659

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1659<400> 1659

ugcaacgcug augagncgaa auacuuc 27ugcaacgcug augagncgaa auacuuc 27

＜210＞ 1660<210> 1660

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1660<400> 1660

cugcugccug augagncgaa acggaua 27cugcugccug augagncgaa acggaua 27

＜210＞ 1661<210> 1661

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1661<400> 1661

uucgcagcug augagncgaa aucucug 27uucgcagcug augagncgaa aucucug 27

＜210＞ 1662<210> 1662

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1662<400> 1662

cuucuugcug augagncgaa auuuucg 27cuucuugcug augagncgaa auuuucg 27

＜210＞ 1663<210> 1663

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1663<400> 1663

gggggggcug augagncgaa acuucuu 27gggggggcug augagncgaa acuucuu 27

＜210＞ 1664<210> 1664

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1664<400> 1664

cggggggcug augagncgaa aacuucu 27cggggggcug augagncgaa aacuucu 27

＜210＞ 1665<210> 1665

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1665<400> 1665

aacagugcug augagncgaa aggguug 27aacagugcug augagncgaa aggguug 27

＜210＞ 1666<210> 1666

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1666<400> 1666

uuuccagcug augagncgaa acucuaa 27uuuccagcug augagncgaa acucuaa 27

＜210＞ 1667<210> 1667

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1667<400> 1667

gguauugcug augagncgaa agggccc 27gguauugcug augagncgaa agggccc 27

＜210＞ 1668<210> 1668

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1668<400> 1668

gaggcggcug augagncgaa auuggag 27gaggcggcug augagncgaa auuggag 27

＜210＞ 1669<210> 1669

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1669<400> 1669

uuccgugcug augagncgaa aggcggu 27uuccgugcug augagncgaa aggcggu 27

＜210＞ 1670<210> 1670

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1670<400> 1670

ucagaaccug augagncgaa accgucc 27ucagaaccug augagncgaa accgucc 27

＜210＞ 1671<210> 1671

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1671<400> 1671

cugucagcug augagncgaa acaaccg 27cugucagcug augagncgaa acaaccg 27

＜210＞ 1672<210> 1672

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1672<400> 1672

ucugucacug augagncgaa aacaacc 27ucugucacug augagncgaa aacaacc 27

＜210＞ 1673<210> 1673

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1673<400> 1673

ggcagaacug augagncgaa acacggu 27ggcagaacug augagncgaa acacggu 27

＜210＞ 1674<210> 1674

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1674<400> 1674

aaggcagcug augagncgaa agacacg 27aaggcagcug augagncgaa agacacg 27

＜210＞ 1675<210> 1675

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1675<400> 1675

caaggcacug augagncgaa aagacac 27caaggcacug augagncgaa aagacac 27

＜210＞ 1676<210> 1676

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1676<400> 1676

cuccgcccug augagncgaa aggcaga 27cuccgcccug augagncgaa aggcaga 27

＜210＞ 1677<210> 1677

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1677<400> 1677

cgauccgcug augagncgaa agcugcc 27cgauccgcug augagncgaa agcugcc 27

＜210＞ 1678<210> 1678

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1678<400> 1678

ugaucggcug augagncgaa aggggcg 27ugaucggcug augagncgaa aggggcg 27

＜210＞ 1679<210> 1679

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1679<400> 1679

gaggucucug augagncgaa aucggga 27gaggucucug augagncgaa aucggga 27

＜210＞ 1680<210> 1680

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1680<400> 1680

gucgucacug augagncgaa aggucug 27gucgucacug augagncgaa aggucug 27

＜210＞ 1681<210> 1681

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1681<400> 1681

aacgucacug augagncgaa auucuuu 27aacgucacug augagncgaa auucuuu 27

＜210＞ 1682<210> 1682

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1682<400> 1682

acgacuccug augagncgaa acgucag 27acgacuccug augagncgaa acgucag 27

＜210＞ 1683<210> 1683

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1683<400> 1683

ggaguaccug augagncgaa acucaac 27ggaguaccug augagncgaa acucaac 27

＜210＞ 1684<210> 1684

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1684<400> 1684

ggaggagcug augagncgaa acgacuc 27ggaggagcug augagncgaa acgacuc 27

＜210＞ 1685<210> 1685

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1685<400> 1685

ccaugugcug augagncgaa aggacau 27ccaugugcug augagncgaa aggacau 27

＜210＞ 1686<210> 1686

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1686<400> 1686

auggcgucug augagncgaa aucaggg 27auggcgucug augagncgaa aucaggg 27

＜210＞ 1687<210> 1687

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1687<400> 1687

guugcuccug augagncgaa acgcguu 27guugcuccug augagncgaa acgcguu 27

＜210＞ 1688<210> 1688

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1688<400> 1688

cagcagacug augagncgaa aguugcu 27cagcagacug augagncgaa aguugcu 27

＜210＞ 1689<210> 1689

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1689<400> 1689

cgcagcacug augagncgaa agaguug 27cgcagcacug augagncgaa agaguug 27

＜210＞ 1690<210> 1690

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1690<400> 1690

uuguggucug augagncgaa acgcagc 27uuguggucug augagncgaa acgcagc 27

＜210＞ 1691<210> 1691

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1691<400> 1691

uggcauacug augagncgaa accaugu 27uggcauacug augagncgaa accaugu 27

＜210＞ 1692<210> 1692

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1692<400> 1692

uguggcacug augagncgaa agaccau 27uguggcacug augagncgaa agaccau 27

＜210＞ 1693<210> 1693

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1693<400> 1693

caaaggucug augagncgaa accuucu 27caaaggucug augagncgaa accuucu 27

＜210＞ 1694<210> 1694

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1694<400> 1694

ucugucacug augagncgaa aggugac 27ucugucacug augagncgaa aggugac 27

＜210＞ 1695<210> 1695

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1695<400> 1695

gucuguccug augagncgaa aagguga 27gucuguccug augagncgaa aagguga 27

＜210＞ 1696<210> 1696

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1696<400> 1696

ucuccuucug augagncgaa agcacgu 27ucuccuucug augagncgaa agcacgu 27

＜210＞ 1697<210> 1697

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1697<400> 1697

aacugugcug augagncgaa acgccuu 27aacugugcug augagncgaa acgccuu 27

＜210＞ 1698<210> 1698

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1698<400> 1698

uagccuucug augagncgaa acugugg 27uagccuucug augagncgaa acugugg 27

＜210＞ 1699<210> 1699

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1699<400> 1699

uuagccucug augagncgaa aacugug 27uuagccucug augagncgaa aacugug 27

＜210＞ 1700<210> 1700

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1700<400> 1700

cggauagcug augagncgaa aguuuag 27cggauagcug augagncgaa aguuuag 27

＜210＞ 1701<210> 1701

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1701<400> 1701

acggauacug augagncgaa aaguuua 27acggauacug augagncgaa aaguuua 27

＜210＞ 1702<210> 1702

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1702<400> 1702

uuggccgcug augagncgaa auguggg 27uuggccgcug augagncgaa auguggg 27

＜210＞ 1703<210> 1703

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1703<400> 1703

uuuggcccug augagncgaa aaugugg 27uuuggcccug augagncgaa aaugugg 27

＜210＞ 1704<210> 1704

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1704<400> 1704

gguuccgcug augagncgaa acguccu 27gguuccgcug augagncgaa acguccu 27

＜210＞ 1705<210> 1705

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1705<400> 1705

ugcuggacug augagncgaa agguucc 27ugcuggacug augagncgaa agguucc 27

＜210＞ 1706<210> 1706

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1706<400> 1706

cuugcugcug augagncgaa auagguu 27cuugcugcug augagncgaa auagguu 27

＜210＞ 1707<210> 1707

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1707<400> 1707

ugugguucug augagncgaa auggccu 27ugugguucug augagncgaa auggccu 27

＜210＞ 1708<210> 1708

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1708<400> 1708

auguggucug augagncgaa aauggcc 27auguggucug augagncgaa aauggcc 27

＜210＞ 1709<210> 1709

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1709<400> 1709

ugguguccug augagncgaa auuggug 27ugguguccug augagncgaa auuggug 27

＜210＞ 1710<210> 1710

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1710<400> 1710

uugccaucug augagncgaa auggugg 27uugccaucug augagncgaa auggugg 27

＜210＞ 1711<210> 1711

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1711<400> 1711

cgcagaacug augagncgaa acuucac 27cgcagaacug augagncgaa acuucac 27

＜210＞ 1712<210> 1712

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1712<400> 1712

acgcagacug augagncgaa aacuuca 27acgcagacug augagncgaa aacuuca 27

＜210＞ 1713<210> 1713

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1713<400> 1713

gacgcagcug augagncgaa aaacuuc 27gacgcagcug augagncgaa aaacuuc 27

＜210＞ 1714<210> 1714

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1714<400> 1714

ggacgcacug augagncgaa aaaacuu 27ggacgcacug augagncgaa aaaacuu 27

＜210＞ 1715<210> 1715

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1715<400> 1715

ccgguugcug augagncgaa acgcaga 27ccgguugcug augagncgaa acgcaga 27

＜210＞ 1716<210> 1716

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1716<400> 1716

auaaggccug augagncgaa agcuggc 27auaaggccug augagncgaa agcuggc 27

＜210＞ 1717<210> 1717

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1717<400> 1717

cugggaacug augagncgaa acgauaa 27cugggaacug augagncgaa acgauaa 27

＜210＞ 1718<210> 1718

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1718<400> 1718

gucugggcug augagncgaa auacgau 27gucugggcug augagncgaa auacgau 27

＜210＞ 1719<210> 1719

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1719<400> 1719

ggucuggcug augagncgaa aauacga 27ggucuggcug augagncgaa aauacga 27

＜210＞ 1720<210> 1720

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1720<400> 1720

auacacgcug augagncgaa acuccca 27auacacgcug augagncgaa acuccca 27

＜210＞ 1721<210> 1721

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1721<400> 1721

cauacaccug augagncgaa aacuccc 27cauacaccug augagncgaa aacuccc 27

＜210＞ 1722<210> 1722

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1722<400> 1722

ucucgcacug augagncgaa acacgaa 27ucucgcacug augagncgaa acacgaa 27

＜210＞ 1723<210> 1723

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1723<400> 1723

ucguaaacug augagncgaa agccauu 27ucguaaacug augagncgaa agccauu 27

＜210＞ 1724<210> 1724

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1724<400> 1724

cgucguacug augagncgaa agagcca 27cgucguacug augagncgaa agagcca 27

＜210＞ 1725<210> 1725

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1725<400> 1725

acgucgucug augagncgaa aagagcc 27acgucgucug augagncgaa aagagcc 27

＜210＞ 1726<210> 1726

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1726<400> 1726

cacgucgcug augagncgaa aaagagc 27cacgucgcug augagncgaa aaagagc 27

＜210＞ 1727<210> 1727

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1727<400> 1727

ggguggacug augagncgaa accacgu 27ggguggacug augagncgaa accacgu 27

＜210＞ 1728<210> 1728

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1728<400> 1728

aagggugcug augagncgaa agaccac 27aagggugcug augagncgaa agaccac 27

＜210＞ 1729<210> 1729

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1729<400> 1729

ccugaggcug augagncgaa agggugg 27ccugaggcug augagncgaa agggugg 27

＜210＞ 1730<210> 1730

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1730<400> 1730

gccugagcug augagncgaa aagggug 27gccugagcug augagncgaa aagggug 27

＜210＞ 1731<210> 1731

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1731<400> 1731

acggccucug augagncgaa aggaagg 27acggccucug augagncgaa aggaagg 27

＜210＞ 1732<210> 1732

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1732<400> 1732

guacgagcug augagncgaa agcccau 27guacgagcug augagncgaa agcccau 27

＜210＞ 1733<210> 1733

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1733<400> 1733

uccguaccug augagncgaa aggagcc 27uccguaccug augagncgaa aggagcc 27

＜210＞ 1734<210> 1734

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1734<400> 1734

aguacugcug augagncgaa aauccgu 27aguacugcug augagncgaa aauccgu 27

＜210＞ 1735<210> 1735

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1735<400> 1735

cccaggacug augagncgaa aguacug 27cccaggacug augagncgaa aguacug 27

＜210＞ 1736<210> 1736

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1736<400> 1736

aagcccacug augagncgaa agggcuu 27aagcccacug augagncgaa agggcuu 27

＜210＞ 1737<210> 1737

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1737<400> 1737

auacgagcug augagncgaa agcccau 27auacgagcug augagncgaa agcccau 27

＜210＞ 1738<210> 1738

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1738<400> 1738

cauacgacug augagncgaa aagccca 27cauacgacug augagncgaa aagccca 27

＜210＞ 1739<210> 1739

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1739<400> 1739

gucauaccug augagncgaa agaagcc 27gucauaccug augagncgaa agaagcc 27

＜210＞ 1740<210> 1740

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1740<400> 1740

ggugucacug augagncgaa acgagaa 27ggugucacug augagncgaa acgagaa 27

＜210＞ 1741<210> 1741

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1741<400> 1741

ugagucacug augagncgaa agcagcg 27ugagucacug augagncgaa agcagcg 27

＜210＞ 1742<210> 1742

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1742<400> 1742

uugaguccug augagncgaa aagcagc 27uugaguccug augagncgaa aagcagc 27

＜210＞ 1743<210> 1743

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1743<400> 1743

gacuguucug augagncgaa agucaaa 27gacuguucug augagncgaa agucaaa 27

＜210＞ 1744<210> 1744

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1744<400> 1744

ucucagucug augagncgaa acuguug 27ucucagucug augagncgaa acuguug 27

＜210＞ 1745<210> 1745

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1745<400> 1745

caacacgcug augagncgaa augucgc 27caacacgcug augagncgaa augucgc 27

＜210＞ 1746<210> 1746

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1746<400> 1746

acuccuccug augagncgaa acacgga 27acuccuccug augagncgaa acacgga 27

＜210＞ 1747<210> 1747

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1747<400> 1747

guagauucug augagncgaa acuccuc 27guagauucug augagncgaa acuccuc 27

＜210＞ 1748<210> 1748

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1748<400> 1748

auugguacug augagncgaa auugacu 27auugguacug augagncgaa auugacu 27

＜210＞ 1749<210> 1749

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1749<400> 1749

acauuggcug augagncgaa agauuga 27acauuggcug augagncgaa agauuga 27

＜210＞ 1750<210> 1750

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1750<400> 1750

aagucaccug augagncgaa acauugg 27aagucaccug augagncgaa acauugg 27

＜210＞ 1751<210> 1751

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1751<400> 1751

gggggcccug augagncgaa agucaca 27gggggcccug augagncgaa agucaca 27

＜210＞ 1752<210> 1752

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1752<400> 1752

uuugaaucug augagncgaa agucagg 27uuugaaucug augagncgaa agucagg 27

＜210＞ 1753<210> 1753

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1753<400> 1753

ccuuuugcug augagncgaa auuaguc 27ccuuuugcug augagncgaa auuaguc 27

＜210＞ 1754<210> 1754

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1754<400> 1754

cccuuuucug augagncgaa aauuagu 27cccuuuucug augagncgaa aauuagu 27

＜210＞ 1755<210> 1755

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1755<400> 1755

gugagggcug augagncgaa auugccg 27gugagggcug augagncgaa auugccg 27

＜210＞ 1756<210> 1756

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1756<400> 1756

agcaugucug augagncgaa aggguau 27agcaugucug augagncgaa aggguau 27

＜210＞ 1757<210> 1757

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1757<400> 1757

uuucaagcug augagncgaa agcaugu 27uuucaagcug augagncgaa agcaugu 27

＜210＞ 1758<210> 1758

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1758<400> 1758

ggcuuuccug augagncgaa aguagca 27ggcuuuccug augagncgaa aguagca 27

＜210＞ 1759<210> 1759

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1759<400> 1759

ucacagacug augagncgaa aacgaca 27ucacagacug augagncgaa aacgaca 27

＜210＞ 1760<210> 1760

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1760<400> 1760

uuucacacug augagncgaa auaacga 27uuucacacug augagncgaa auaacga 27

＜210＞ 1761<210> 1761

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1761<400> 1761

agacucgcug augagncgaa aggcucg 27agacucgcug augagncgaa aggcucg 27

＜210＞ 1762<210> 1762

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1762<400> 1762

ccgugaacug augagncgaa acucgua 27ccgugaacug augagncgaa acucgua 27

＜210＞ 1763<210> 1763

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1763<400> 1763

cuccgugcug augagncgaa agacucg 27cuccgugcug augagncgaa agacucg 27

＜210＞ 1764<210> 1764

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1764<400> 1764

ccuccgucug augagncgaa aagacuc 27ccuccgucug augagncgaa aagacuc 27

＜210＞ 1765<210> 1765

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1765<400> 1765

cuagucacug augagncgaa agccucc 27cuagucacug augagncgaa agccucc 27

＜210＞ 1766<210> 1766

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1766<400> 1766

gaguacccug augagncgaa agucaua 27gaguacccug augagncgaa agucaua 27

＜210＞ 1767<210> 1767

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1767<400> 1767

ggcagagcug augagncgaa accuagu 27ggcagagcug augagncgaa accuagu 27

＜210＞ 1768<210> 1768

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1768<400> 1768

caacucccug augagncgaa agucgua 27caacucccug augagncgaa agucgua 27

＜210＞ 1769<210> 1769

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1769<400> 1769

uguuauccug augagncgaa acuccaa 27uguuauccug augagncgaa acuccaa 27

＜210＞ 1770<210> 1770

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1770<400> 1770

augaugucug augagncgaa aucaacu 27augaugucug augagncgaa aucaacu 27

＜210＞ 1771<210> 1771

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1771<400> 1771

ggagcaucug augagncgaa auguuau 27ggagcaucug augagncgaa auguuau 27

＜210＞ 1772<210> 1772

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1772<400> 1772

cgcgacccug augagncgaa acacguu 27cgcgacccug augagncgaa acacguu 27

＜210＞ 1773<210> 1773

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1773<400> 1773

cgugcgccug augagncgaa accgaca 27cgugcgccug augagncgaa accgaca 27

＜210＞ 1774<210> 1774

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1774<400> 1774

gagguagcug augagncgaa acacucu 27gagguagcug augagncgaa acacucu 27

＜210＞ 1775<210> 1775

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1775<400> 1775

agugaggcug augagncgaa aguacac 27agugaggcug augagncgaa aguacac 27

＜210＞ 1776<210> 1776

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1776<400> 1776

cacgagucug augagncgaa agguagu 27cacgagucug augagncgaa agguagu 27

＜210＞ 1777<210> 1777

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1777<400> 1777

ggaucaccug augagncgaa agugagg 27ggaucaccug augagncgaa agugagg 27

＜210＞ 1778<210> 1778

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1778<400> 1778

gugguggcug augagncgaa aucacga 27gugguggcug augagncgaa aucacga 27

＜210＞ 1779<210> 1779

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1779<400> 1779

guguguccug augagncgaa agcuguc 27guguguccug augagncgaa agcuguc 27

＜210＞ 1780<210> 1780

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1780<400> 1780

uugacugcug augagncgaa agugugu 27uugacugcug augagncgaa agugugu 27

＜210＞ 1781<210> 1781

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1781<400> 1781

aggaguucug augagncgaa acuggag 27aggaguucug augagncgaa acuggag 27

＜210＞ 1782<210> 1782

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1782<400> 1782

uagccagcug augagncgaa aguugac 27uagccagcug augagncgaa aguugac 27

＜210＞ 1783<210> 1783

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1783<400> 1783

uguugcccug augagncgaa agccagg 27uguugcccug augagncgaa agccagg 27

＜210＞ 1784<210> 1784

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1784<400> 1784

acaugaucug augagncgaa auguugc 27acaugaucug augagncgaa auguugc 27

＜210＞ 1785<210> 1785

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1785<400> 1785

cauacaucug augagncgaa augaugu 27cauacaucug augagncgaa augaugu 27

＜210＞ 1786<210> 1786

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1786<400> 1786

ucaucaacug augagncgaa aucaucc 27ucaucaacug augagncgaa aucaucc 27

＜210＞ 1787<210> 1787

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1787<400> 1787

agucauccug augagncgaa aaaucau 27agucauccug augagncgaa aaaucau 27

＜210＞ 1788<210> 1788

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1788<400> 1788

ggagaagcug augagncgaa agugagu 27ggagaagcug augagncgaa agugagu 27

＜210＞ 1789<210> 1789

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1789<400> 1789

uggagaacug augagncgaa aagugag 27uggagaacug augagncgaa aagugag 27

＜210＞ 1790<210> 1790

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1790<400> 1790

gauggagcug augagncgaa agaagug 27gauggagcug augagncgaa agaagug 27

＜210＞ 1791<210> 1791

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1791<400> 1791

ggauggacug augagncgaa aagaagu 27ggauggacug augagncgaa aagaagu 27

＜210＞ 1792<210> 1792

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1792<400> 1792

aaggaugcug augagncgaa agaagaa 27aaggaugcug augagncgaa agaagaa 27

＜210＞ 1793<210> 1793

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1793<400> 1793

cuagaagcug augagncgaa auggaga 27cuagaagcug augagncgaa auggaga 27

＜210＞ 1794<210> 1794

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1794<400> 1794

gggcuagcug augagncgaa aggaugg 27gggcuagcug augagncgaa aggaugg 27

＜210＞ 1795<210> 1795

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1795<400> 1795

ugggcuacug augagncgaa aaggaug 27ugggcuacug augagncgaa aaggaug 27

＜210＞ 1796<210> 1796

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1796<400> 1796

ccugggccug augagncgaa agaagga 27ccugggccug augagncgaa agaagga 27

＜210＞ 1797<210> 1797

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1797<400> 1797

ccuuuuccug augagncgaa agcuguu 27ccuuuuccug augagncgaa agcuguu 27

＜210＞ 1798<210> 1798

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1798<400> 1798

auggagucug augagncgaa acaggcc 27auggagucug augagncgaa acaggcc 27

＜210＞ 1799<210> 1799

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1799<400> 1799

aauggagcug augagncgaa aacaggc 27aauggagcug augagncgaa aacaggc 27

＜210＞ 1800<210> 1800

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1800<400> 1800

cucaaugcug augagncgaa aguaaca 27cucaaugcug augagncgaa aguaaca 27

＜210＞ 1801<210> 1801

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1801<400> 1801

guggcuccug augagncgaa auggagu 27guggcuccug augagncgaa auggagu 27

＜210＞ 1802<210> 1802

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1802<400> 1802

guagguccug augagncgaa aguggcu 27guagguccug augagncgaa aguggcu 27

＜210＞ 1803<210> 1803

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1803<400> 1803

ucugaggcug augagncgaa aggucaa 27ucugaggcug augagncgaa aggucaa 27

＜210＞ 1804<210> 1804

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1804<400> 1804

augaucucug augagncgaa agguagg 27augaucucug augagncgaa agguagg 27

＜210＞ 1805<210> 1805

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1805<400> 1805

guugaaucug augagncgaa aucugag 27guugaaucug augagncgaa aucugag 27

＜210＞ 1806<210> 1806

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1806<400> 1806

gucguugcug augagncgaa augaucu 27gucguugcug augagncgaa augaucu 27

＜210＞ 1807<210> 1807

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1807<400> 1807

agucguucug augagncgaa aaugauc 27agucguucug augagncgaa aaugauc 27

＜210＞ 1808<210> 1808

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1808<400> 1808

gaccaugcug augagncgaa agucguu 27gaccaugcug augagncgaa agucguu 27

＜210＞ 1809<210> 1809

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1809<400> 1809

gcgcuaacug augagncgaa accaugg 27gcgcuaacug augagncgaa accaugg 27

＜210＞ 1810<210> 1810

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1810<400> 1810

augcgcucug augagncgaa agaccau 27augcgcucug augagncgaa agaccau 27

＜210＞ 1811<210> 1811

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1811<400> 1811

aaugcgccug augagncgaa aagacca 27aaugcgccug augagncgaa aagacca 27

＜210＞ 1812<210> 1812

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1812<400> 1812

gagugagcug augagncgaa augcgcu 27gagugagcug augagncgaa augcgcu 27

＜210＞ 1813<210> 1813

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1813<400> 1813

ggagugacug augagncgaa aaugcgc 27ggagugacug augagncgaa aaugcgc 27

＜210＞ 1814<210> 1814

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1814<400> 1814

auggagucug augagncgaa agaaugc 27auggagucug augagncgaa agaaugc 27

＜210＞ 1815<210> 1815

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1815<400> 1815

aacuaugcug augagncgaa agugaga 27aacuaugcug augagncgaa agugaga 27

＜210＞ 1816<210> 1816

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1816<400> 1816

gaguaaccug augagncgaa auggagu 27gaguaaccug augagncgaa auggagu 27

＜210＞ 1817<210> 1817

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1817<400> 1817

ggagagucug augagncgaa acuaugg 27ggagagucug augagncgaa acuaugg 27

＜210＞ 1818<210> 1818

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1818<400> 1818

uggagagcug augagncgaa aacuaug 27uggagagcug augagncgaa aacuaug 27

＜210＞ 1819<210> 1819

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1819<400> 1819

accuggacug augagncgaa aguaacu 27accuggacug augagncgaa aguaacu 27

＜210＞ 1820<210> 1820

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1820<400> 1820

ucaccugcug augagncgaa agaguaa 27ucaccugcug augagncgaa agaguaa 27

＜210＞ 1821<210> 1821

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1821<400> 1821

cccuauucug augagncgaa aucucac 27cccuauucug augagncgaa aucucac 27

＜210＞ 1822<210> 1822

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1822<400> 1822

gccaccccug augagncgaa auugauc 27gccaccccug augagncgaa auugauc 27

＜210＞ 1823<210> 1823

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1823<400> 1823

aggcaugcug augagncgaa agccacc 27aggcaugcug augagncgaa agccacc 27

＜210＞ 1824<210> 1824

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1824<400> 1824

gaggcaucug augagncgaa aagccac 27gaggcaucug augagncgaa aagccac 27

＜210＞ 1825<210> 1825

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1825<400> 1825

cuggccccug augagncgaa augucuc 27cuggccccug augagncgaa augucuc 27

＜210＞ 1826<210> 1826

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1826<400> 1826

gaagaggcug augagncgaa acuugcc 27gaagaggcug augagncgaa acuugcc 27

＜210＞ 1827<210> 1827

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1827<400> 1827

aguugaacug augagncgaa agguacu 27aguugaacug augagncgaa agguacu 27

＜210＞ 1828<210> 1828

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1828<400> 1828

ccaguugcug augagncgaa agaggua 27ccaguugcug augagncgaa agaggua 27

＜210＞ 1829<210> 1829

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1829<400> 1829

cccaguucug augagncgaa aagaggu 27cccaguucug augagncgaa aagaggu 27

＜210＞ 1830<210> 1830

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1830<400> 1830

ugguccucug augagncgaa acugccc 27ugguccucug augagncgaa acugccc 27

＜210＞ 1831<210> 1831

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1831<400> 1831

ugaguuucug augagncgaa agcuugg 27ugaguuucug augagncgaa agcuugg 27

＜210＞ 1832<210> 1832

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1832<400> 1832

uuggagucug augagncgaa aguuuga 27uuggagucug augagncgaa aguuuga 27

＜210＞ 1833<210> 1833

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1833<400> 1833

gggauugcug augagncgaa agugagu 27gggauugcug augagncgaa agugagu 27

＜210＞ 1834<210> 1834

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1834<400> 1834

cggccggcug augagncgaa auuggag 27cggccggcug augagncgaa auuggag 27

＜210＞ 1835<210> 1835

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1835<400> 1835

ccgcugucug augagncgaa accagca 27ccgcugucug augagncgaa accagca 27

＜210＞ 1836<210> 1836

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1836<400> 1836

cccgcugcug augagncgaa aaccagc 27cccgcugcug augagncgaa aaccagc 27

＜210＞ 1837<210> 1837

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1837<400> 1837

cgggcaccug augagncgaa agacagg 27cgggcaccug augagncgaa agacagg 27

＜210＞ 1838<210> 1838

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1838<400> 1838

ccacauacug augagncgaa accagcg 27ccacauacug augagncgaa accagcg 27

＜210＞ 1839<210> 1839

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1839<400> 1839

accacaucug augagncgaa aaccagc 27accacaucug augagncgaa aaccagc 27

＜210＞ 1840<210> 1840

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1840<400> 1840

caccacacug augagncgaa aaaccag 27caccacacug augagncgaa aaaccag 27

＜210＞ 1841<210> 1841

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1841<400> 1841

aaaagggcug augagncgaa auggccu 27aaaagggcug augagncgaa auggccu 27

＜210＞ 1842<210> 1842

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hammerhead (HH) Ribozyme<223> Synthesized HCV Hammerhead (HH) Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 1842<400> 1842

aaaaaaacug augagncgaa aggggau 27aaaaaaacug augagncgaa aggggau 27

＜210＞ 1843<210> 1843

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1843<400> 1843

ccccgauugg gggcg 15ccccgauugg gggcg 15

＜210＞ 1844<210> 1844

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1844<400> 1844

ccaccauaga ucacu 15ccaccauaga ucacu 15

＜210＞ 1845<210> 1845

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1845<400> 1845

cauagaucac ucccc 15cauagaucac ucccc 15

＜210＞ 1846<210> 1846

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1846<400> 1846

gaucacuccc cugug 15gaucacuccc cugug 15

＜210＞ 1847<210> 1847

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1847<400> 1847

aggaacuacu gucuu 15aggaacuacu gucuu 15

＜210＞ 1848<210> 1848

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1848<400> 1848

cuacugucuu cacgc 15cuacugucuu cacgc 15

＜210＞ 1849<210> 1849

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1849<400> 1849

acugucuuca cgcag 15acugucuuca cgcag 15

＜210＞ 1850<210> 1850

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1850<400> 1850

cugucuucac gcaga 15cugucuucac gcaga 15

＜210＞ 1851<210> 1851

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1851<400> 1851

aaagcgucua gccau 15aaagcgucua gccau 15

＜210＞ 1852<210> 1852

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1852<400> 1852

agcgucuagc caugg 15agcgucuagc caugg 15

＜210＞ 1853<210> 1853

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1853<400> 1853

auggcguuag uauga 15auggcguuag uauga 15

＜210＞ 1854<210> 1854

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1854<400> 1854

uggcguuagu augag 15uggcguuagu augag 15

＜210＞ 1855<210> 1855

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1855<400> 1855

cguuaguaug agugu 15cguuaguaug agugu 15

＜210＞ 1856<210> 1856

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1856<400> 1856

ugagugucgu gcagc 15ugagugucgu gcagc 15

＜210＞ 1857<210> 1857

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1857<400> 1857

gagccauagu ggucu 15gagccauagu ggucu 15

＜210＞ 1858<210> 1858

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1858<400> 1858

accggguccu uucuu 15accggguccu uucuu 15

＜210＞ 1859<210> 1859

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1859<400> 1859

ggguccuuuc uugga 15ggguccuuuc uugga 15

＜210＞ 1860<210> 1860

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1860<400> 1860

gguccuuucu uggau 15gguccuuucu uggau 15

＜210＞ 1861<210> 1861

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1861<400> 1861

guccuuucuu ggauc 15guccuuucuu ggauc 15

＜210＞ 1862<210> 1862

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1862<400> 1862

cuuggaucaa cccgc 15cuuggaucaa cccgc 15

＜210＞ 1863<210> 1863

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1863<400> 1863

uggagauuug ggcgu 15uggagauuug ggcgu 15

＜210＞ 1864<210> 1864

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1864<400> 1864

ggagauuugg gcgug 15ggagauuugg gcgug 15

＜210＞ 1865<210> 1865

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1865<400> 1865

aaggccuugu gguac 15aaggccuugu gguac 15

＜210＞ 1866<210> 1866

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1866<400> 1866

cacgaauccu aaacc 15cacgaauccu aaacc 15

＜210＞ 1867<210> 1867

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1867<400> 1867

gaauccuaaa ccuca 15gaauccuaaa ccuca 15

＜210＞ 1868<210> 1868

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1868<400> 1868

uaaaccucaa agaaa 15uaaaccucaa agaaa 15

＜210＞ 1869<210> 1869

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1869<400> 1869

caaacguaac accua 15caaacguaac accua 15

＜210＞ 1870<210> 1870

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1870<400> 1870

aacaccuacc gccgc 15aacaccuacc gccgc 15

＜210＞ 1871<210> 1871

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1871<400> 1871

gucagaucgu uggug 15gucagaucgu uggug 15

＜210＞ 1872<210> 1872

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1872<400> 1872

agaucguugg uggag 15agaucguugg uggag 15

＜210＞ 1873<210> 1873

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1873<400> 1873

guggaguuua cgugu 15guggaguuua cgugu 15

＜210＞ 1874<210> 1874

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1874<400> 1874

uggaguuuac guguu 15uggaguuuac guguu 15

＜210＞ 1875<210> 1875

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1875<400> 1875

ggaguuuacg uguug 15ggaguuuacg uguug 15

＜210＞ 1876<210> 1876

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1876<400> 1876

uacguguugc cgcgc 15uacguguugc cgcgc 15

＜210＞ 1877<210> 1877

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1877<400> 1877

gcaaccucgu ggaag 15gcaaccucgu ggaag 15

＜210＞ 1878<210> 1878

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1878<400> 1878

cggaggucgc gcaau 15cggaggucgc gcaau 15

＜210＞ 1879<210> 1879

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1879<400> 1879

ucuggguaag gucau 15ucuggguaag gucau 15

＜210＞ 1880<210> 1880

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1880<400> 1880

auacccucac gugcg 15auacccucac gugcg 15

＜210＞ 1881<210> 1881

＜211＞ 15<211> 15

＜212＞ RNA ＜213＞ Hepatitis C Virus<212> RNA <213> Hepatitis C Virus

＜400＞ 1881<400> 1881

ccgaccucau ggggu 15ccgaccucau ggggu 15

＜210＞ 1882<210> 1882

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1882<400> 1882

uugcucuuuc ucuau 15uugcucuuuc ucuau 15

＜210＞ 1883<210> 1883

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1883<400> 1883

ugcucuuucu cuauc 15ugcucuuucu cuauc 15

＜210＞ 1884<210> 1884

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1884<400> 1884

gcucuuucuc uaucu 15gcucuuucuc uaucu 15

＜210＞ 1885<210> 1885

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1885<400> 1885

ucuuucucua ucuuc 15ucuuucucua ucuuc 15

＜210＞ 1886<210> 1886

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1886<400> 1886

uuucucuauc uuccu 15uuucucuauc uuccu 15

＜210＞ 1887<210> 1887

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1887<400> 1887

ucucuaucuu ccucu 15ucucuaucuu ccucu 15

＜210＞ 1888<210> 1888

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1888<400> 1888

ucuaucuucc ucuug 15ucuaucuucc ucuug 15

＜210＞ 1889<210> 1889

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1889<400> 1889

cuaucuuccu cuugg 15cuaucuuccu cuugg 15

＜210＞ 1890<210> 1890

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1890<400> 1890

ucuuccucuu ggccc 15ucuuccucuu ggccc 15

＜210＞ 1891<210> 1891

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1891<400> 1891

uuccucuugg cccug 15uuccucuugg cccug 15

＜210＞ 1892<210> 1892

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1892<400> 1892

cugcuguccu guuug 15cugcuguccu guuug 15

＜210＞ 1893<210> 1893

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1893<400> 1893

guccuguuug accau 15guccuguuug accau 15

＜210＞ 1894<210> 1894

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1894<400> 1894

uccuguuuga ccauc 15uccuguuuga ccauc 15

＜210＞ 1895<210> 1895

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1895<400> 1895

ugaccauccc agcuu 15ugaccauccc agcuu 15

＜210＞ 1896<210> 1896

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1896<400> 1896

cccagcuucc gcuua 15cccagcuucc gcuua 15

＜210＞ 1897<210> 1897

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1897<400> 1897

ccagcuuccg cuuau 15ccagcuuccg cuuau 15

＜210＞ 1898<210> 1898

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1898<400> 1898

uuccgcuuau caggu 15uuccgcuuau caggu 15

＜210＞ 1899<210> 1899

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1899<400> 1899

uccgcuuauc aggug 15uccgcuuauc aggug 15

＜210＞ 1900<210> 1900

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1900<400> 1900

cgcuuaucag gugcg 15cgcuuaucag gugcg 15

＜210＞ 1901<210> 1901

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1901<400> 1901

aacgcauccg ggcug 15aacgcauccg ggcug 15

＜210＞ 1902<210> 1902

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1902<400> 1902

gggcuguacc auguc 15gggcuguacc auguc 15

＜210＞ 1903<210> 1903

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1903<400> 1903

accaugucac gaaug 15accaugucac gaaug 15

＜210＞ 1904<210> 1904

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1904<400> 1904

gacugcucca acuca 15gacugcucca acuca 15

＜210＞ 1905<210> 1905

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1905<400> 1905

uccaacucaa gcauu 15uccaacucaa gcauu 15

＜210＞ 1906<210> 1906

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1906<400> 1906

caagcauugu guaug 15caagcauugu guaug 15

＜210＞ 1907<210> 1907

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1907<400> 1907

caugcauacc cccgg 15caugcauacc cccgg 15

＜210＞ 1908<210> 1908

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1908<400> 1908

uagcgcucac uccca 15uagcgcucac uccca 15

＜210＞ 1909<210> 1909

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1909<400> 1909

gcucacuccc acgcu 15gcucacuccc acgcu 15

＜210＞ 1910<210> 1910

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1910<400> 1910

ccacgcucgc ggcca 15ccacgcucgc ggcca 15

＜210＞ 1911<210> 1911

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1911<400> 1911

ccagcauccc cacua 15ccagcauccc cacua 15

＜210＞ 1912<210> 1912

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1912<400> 1912

ccccacuacg acaau 15ccccacuacg acaau 15

＜210＞ 1913<210> 1913

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1913<400> 1913

cgacaauacg acgcc 15cgacaauacg acgcc 15

＜210＞ 1914<210> 1914

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1914<400> 1914

ggccgcuuuc uguuc 15ggccgcuuuc uguuc 15

＜210＞ 1915<210> 1915

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1915<400> 1915

gggaccucug cggau 15gggaccucug cggau 15

＜210＞ 1916<210> 1916

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1916<400> 1916

uuuuccucgu cuccc 15uuuuccucgu cuccc 15

＜210＞ 1917<210> 1917

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1917<400> 1917

uccucgucuc ccagu 15uccucgucuc ccagu 15

＜210＞ 1918<210> 1918

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1918<400> 1918

cucgucuccc aguug 15cucgucuccc aguug 15

＜210＞ 1919<210> 1919

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1919<400> 1919

ucccaguugu ucacc 15ucccaguugu ucacc 15

＜210＞ 1920<210> 1920

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1920<400> 1920

caguuguuca ccuuc 15caguuguuca ccuuc 15

＜210＞ 1921<210> 1921

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1921<400> 1921

aguuguucac cuucu 15aguuguucac cuucu 15

＜210＞ 1922<210> 1922

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1922<400> 1922

uucaccuucu cgccu 15uucaccuucu cgccu 15

＜210＞ 1923<210> 1923

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1923<400> 1923

ucaccuucuc gccuc 15ucaccuucuc gccuc 15

＜210＞ 1924<210> 1924

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1924<400> 1924

accuucucgc cucgc 15accuucucgc cucgc 15

＜210＞ 1925<210> 1925

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1925<400> 1925

cucgccucgc cggua 15cucgccucgc cggua 15

＜210＞ 1926<210> 1926

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1926<400> 1926

cgccgguaug agaca 15cgccgguaug agaca 15

＜210＞ 1927<210> 1927

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1927<400> 1927

agacaguaca ggacu 15agacaguaca ggacu 15

＜210＞ 1928<210> 1928

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1928<400> 1928

cugcaauugc ucaau 15cugcaauugc ucaau 15

＜210＞ 1929<210> 1929

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1929<400> 1929

aauugcucaa ucuau 15aauugcucaa ucuau 15

＜210＞ 1930<210> 1930

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1930<400> 1930

gcucaaucua ucccg 15gcucaaucua ucccg 15

＜210＞ 1931<210> 1931

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1931<400> 1931

ucaaucuauc ccggc 15ucaaucuauc ccggc 15

＜210＞ 1932<210> 1932

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1932<400> 1932

aaucuauccc ggcca 15aaucuauccc ggcca 15

＜210＞ 1933<210> 1933

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1933<400> 1933

cauggcuugg gauau 15cauggcuugg gauau 15

＜210＞ 1934<210> 1934

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1934<400> 1934

uugggauaug augau 15uugggauaug augau 15

＜210＞ 1935<210> 1935

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1935<400> 1935

aacuggucgc cuaca 15aacuggucgc cuaca 15

＜210＞ 1936<210> 1936

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1936<400> 1936

gucgccuaca acagc 15gucgccuaca acagc 15

＜210＞ 1937<210> 1937

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1937<400> 1937

cagcccuagu ggugu 15cagcccuagu ggugu 15

＜210＞ 1938<210> 1938

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1938<400> 1938

guggugucgc aguua 15guggugucgc aguua 15

＜210＞ 1939<210> 1939

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1939<400> 1939

ucgcaguuac uccgg 15ucgcaguuac uccgg 15

＜210＞ 1940<210> 1940

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1940<400> 1940

cgcaguuacu ccgga 15cgcaguuacu ccgga 15

＜210＞ 1941<210> 1941

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1941<400> 1941

aguuacuccg gaucc 15aguuacuccg gaucc 15

＜210＞ 1942<210> 1942

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1942<400> 1942

uccggauccc acaag 15uccggauccc acaag 15

＜210＞ 1943<210> 1943

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1943<400> 1943

cugggcuaag gucuu 15cugggcuaag gucuu 15

＜210＞ 1944<210> 1944

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1944<400> 1944

cuaaggucuu gauug 15cuaaggucuu gauug 15

＜210＞ 1945<210> 1945

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1945<400> 1945

aaggucuuga uugug 15aaggucuuga uugug 15

＜210＞ 1946<210> 1946

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1946<400> 1946

ucuugauugu gaugu 15ucuugauugu gaugu 15

＜210＞ 1947<210> 1947

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1947<400> 1947

gugauguuac ucuuu 15gugauguuac ucuuu 15

＜210＞ 1948<210> 1948

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1948<400> 1948

ugauguuacu cuuug 15ugauguuacu cuuug 15

＜210＞ 1949<210> 1949

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1949<400> 1949

uguuacucuu ugccg 15uguuacucuu ugccg 15

＜210＞ 1950<210> 1950

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1950<400> 1950

uuacucuuug ccggc 15uuacucuuug ccggc 15

＜210＞ 1951<210> 1951

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1951<400> 1951

uacucuuugc cggcg 15uacucuuugc cggcg 15

＜210＞ 1952<210> 1952

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1952<400> 1952

ccggcguuga cgggg 15ccggcguuga cgggg 15

＜210＞ 1953<210> 1953

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1953<400> 1953

acggggucac uuaca 15acggggucac uuaca 15

＜210＞ 1954<210> 1954

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1954<400> 1954

ggucacuuac acgac 15ggucacuuac acgac 15

＜210＞ 1955<210> 1955

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1955<400> 1955

gucacuuaca cgaca 15gucacuuaca cgaca 15

＜210＞ 1956<210> 1956

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1956<400> 1956

ggggggucgc aagcu 15ggggggucgc aagcu 15

＜210＞ 1957<210> 1957

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1957<400> 1957

gcaagcucgc cacac 15gcaagcucgc cacac 15

＜210＞ 1958<210> 1958

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1958<400> 1958

agagcgucac guccu 15agagcgucac guccu 15

＜210＞ 1959<210> 1959

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1959<400> 1959

gucacguccu ucuuc 15gucacguccu ucuuc 15

＜210＞ 1960<210> 1960

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1960<400> 1960

acguccuucu ucacc 15acguccuucu ucacc 15

＜210＞ 1961<210> 1961

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1961<400> 1961

cguccuucuu caccc 15cguccuucuu caccc 15

＜210＞ 1962<210> 1962

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1962<400> 1962

uccuucuuca cccaa 15uccuucuuca cccaa 15

＜210＞ 1963<210> 1963

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1963<400> 1963

ccuucuucac ccaag 15ccuucuucac ccaag 15

＜210＞ 1964<210> 1964

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1964<400> 1964

agagaaucca gcuca 15agagaaucca gcuca 15

＜210＞ 1965<210> 1965

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1965<400> 1965

uccagcucau aaaca 15uccagcucau aaaca 15

＜210＞ 1966<210> 1966

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1966<400> 1966

agcucauaaa cacca 15agcucauaaa cacca 15

＜210＞ 1967<210> 1967

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1967<400> 1967

ggcacaucaa cagga 15ggcacaucaa cagga 15

＜210＞ 1968<210> 1968

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1968<400> 1968

aaugaauccc ucaac 15aaugaauccc ucaac 15

＜210＞ 1969<210> 1969

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1969<400> 1969

aaucccucaa caccg 15aaucccucaa caccg 15

＜210＞ 1970<210> 1970

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1970<400> 1970

accggguucu uugcc 15accggguucu uugcc 15

＜210＞ 1971<210> 1971

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1971<400> 1971

ccggguucuu ugccg 15ccggguucuu ugccg 15

＜210＞ 1972<210> 1972

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1972<400> 1972

ggguucuuug ccgca 15ggguucuuug ccgca 15

＜210＞ 1973<210> 1973

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1973<400> 1973

gguucuuugc cgcac 15gguucuuugc cgcac 15

＜210＞ 1974<210> 1974

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1974<400> 1974

gcacuguucu acgca 15gcacuguucu acgca 15

＜210＞ 1975<210> 1975

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1975<400> 1975

cacuguucua cgcac 15cacuguucua cgcac 15

＜210＞ 1976<210> 1976

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1976<400> 1976

cuguucuacg cacac 15cuguucuacg cacac 15

＜210＞ 1977<210> 1977

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1977<400> 1977

cacaaguuca acucg 15cacaaguuca acucg 15

＜210＞ 1978<210> 1978

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1978<400> 1978

acaaguucaa cucgu 15acaaguucaa cucgu 15

＜210＞ 1979<210> 1979

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1979<400> 1979

uucaacucgu ccgga 15uucaacucgu ccgga 15

＜210＞ 1980<210> 1980

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1980<400> 1980

aacucguccg gaugc 15aacucguccg gaugc 15

＜210＞ 1981<210> 1981

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1981<400> 1981

ugcagcucca ucgac 15ugcagcucca ucgac 15

＜210＞ 1982<210> 1982

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1982<400> 1982

caccuauacc gagcc 15caccuauacc gagcc 15

＜210＞ 1983<210> 1983

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1983<400> 1983

cgagccuagg gaccu 15cgagccuagg gaccu 15

＜210＞ 1984<210> 1984

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1984<400> 1984

ccuggaucag aggcc 15ccuggaucag aggcc 15

＜210＞ 1985<210> 1985

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1985<400> 1985

gaggccuuac ugcug 15gaggccuuac ugcug 15

＜210＞ 1986<210> 1986

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1986<400> 1986

ccaguguacu guuuc 15ccaguguacu guuuc 15

＜210＞ 1987<210> 1987

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1987<400> 1987

guacuguuuc acccc 15guacuguuuc acccc 15

＜210＞ 1988<210> 1988

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1988<400> 1988

uacuguuuca cccca 15uacuguuuca cccca 15

＜210＞ 1989<210> 1989

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1989<400> 1989

acuguuucac cccaa 15acuguuucac cccaa 15

＜210＞ 1990<210> 1990

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1990<400> 1990

ugcugcuucu caaca 15ugcugcuucu caaca 15

＜210＞ 1991<210> 1991

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1991<400> 1991

gcugcuucuc aacaa 15gcugcuucuc aacaa 15

＜210＞ 1992<210> 1992

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1992<400> 1992

ugcuucucaa caaca 15ugcuucucaa caaca 15

＜210＞ 1993<210> 1993

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1993<400> 1993

acuggguuca ccaag 15acuggguuca ccaag 15

＜210＞ 1994<210> 1994

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1994<400> 1994

cuggguucac caaga 15cuggguucac caaga 15

＜210＞ 1995<210> 1995

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1995<400> 1995

cacggauugc uuucg 15cacggauugc uuucg 15

＜210＞ 1996<210> 1996

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1996<400> 1996

gauugcuuuc ggaag 15gauugcuuuc ggaag 15

＜210＞ 1997<210> 1997

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1997<400> 1997

auugcuuucg gaagc 15auugcuuucg gaagc 15

＜210＞ 1998<210> 1998

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1998<400> 1998

uugcuuucgg aagca 15uugcuuucgg aagca 15

＜210＞ 1999<210> 1999

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 1999<400> 1999

aacaccuagg uguau 15aacaccuagg uguau 15

＜210＞ 2000<210> 2000

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2000<400> 2000

uagguguaua guuga 15uagguguaua guuga 15

＜210＞ 2001<210> 2001

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2001<400> 2001

gguguauagu ugacu 15gguguauagu ugacu 15

＜210＞ 2002<210> 2002

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2002<400> 2002

guauaguuga cuacc 15guauaguuga cuacc 15

＜210＞ 2003<210> 2003

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2003<400> 2003

guugacuacc cauac 15guugacuacc cauac 15

＜210＞ 2004<210> 2004

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2004<400> 2004

uacccauaca ggcuc 15uacccauaca ggcuc 15

＜210＞ 2005<210> 2005

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2005<400> 2005

acaggcucug gcacu 15acaggcucug gcacu 15

＜210＞ 2006<210> 2006

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2006<400> 2006

uggcacuacc ccugc 15uggcacuacc ccugc 15

＜210＞ 2007<210> 2007

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2007<400> 2007

gcacugucaa cuuua 15gcacugucaa cuuua 15

＜210＞ 2008<210> 2008

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2008<400> 2008

gucaacuuua ccauc 15gucaacuuua ccauc 15

＜210＞ 2009<210> 2009

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2009<400> 2009

ucaacuuuac caucu 15ucaacuuuac caucu 15

＜210＞ 2010<210> 2010

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2010<400> 2010

caacuuuacc aucuu 15caacuuuacc aucuu 15

＜210＞ 2011<210> 2011

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2011<400> 2011

ccaucuuuaa gguua 15ccaucuuuaa gguua 15

＜210＞ 2012<210> 2012

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2012<400> 2012

caucuuuaag guuag 15caucuuuaag guuag 15

＜210＞ 2013<210> 2013

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2013<400> 2013

uuaagguuag gaugu 15uuaagguuag gaugu 15

＜210＞ 2014<210> 2014

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2014<400> 2014

uaagguuagg augua 15uaagguuagg augua 15

＜210＞ 2015<210> 2015

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2015<400> 2015

aggauguaug ugggg 15aggauguaug ugggg 15

＜210＞ 2016<210> 2016

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2016<400> 2016

cuggacucga ggaga 15cuggacucga ggaga 15

＜210＞ 2017<210> 2017

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2017<400> 2017

agacacuucc cuguu 15agacacuucc cuguu 15

＜210＞ 2018<210> 2018

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2018<400> 2018

gacacuuccc uguuc 15gacacuuccc uguuc 15

＜210＞ 2019<210> 2019

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2019<400> 2019

ucccuguucc uucac 15ucccuguucc uucac 15

＜210＞ 2020<210> 2020

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2020<400> 2020

cccuguuccu ucacc 15cccuguuccu ucacc 15

＜210＞ 2021<210> 2021

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2021<400> 2021

uguuccuuca ccacc 15uguuccuuca ccacc 15

＜210＞ 2022<210> 2022

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2022<400> 2022

guuccuucac caccc 15guuccuucac caccc 15

＜210＞ 2023<210> 2023

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus ＜400＞ 2023<213> Hepatitis C Virus <400> 2023

ccacccuacc ggcuc 15ccacccuacc ggcuc 15

＜210＞ 2024<210> 2024

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2024<400> 2024

accggcucug uccac 15accggcucug uccac 15

＜210＞ 2025<210> 2025

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2025<400> 2025

gcucugucca cuggu 15gcucugucca cuggu 15

＜210＞ 2026<210> 2026

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2026<400> 2026

cacugguuug aucca 15cacugguuug aucca 15

＜210＞ 2027<210> 2027

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2027<400> 2027

acugguuuga uccac 15acugguuuga uccac 15

＜210＞ 2028<210> 2028

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2028<400> 2028

guuugaucca ccucc 15guuugaucca ccucc 15

＜210＞ 2029<210> 2029

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2029<400> 2029

gugcaguacc uguac 15gugcaguacc uguac 15

＜210＞ 2030<210> 2030

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2030<400> 2030

uaccuguacg guaua 15uaccuguacg guaua 15

＜210＞ 2031<210> 2031

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2031<400> 2031

guacgguaua ggguc 15guacgguaua ggguc 15

＜210＞ 2032<210> 2032

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2032<400> 2032

acgguauagg gucag 15acgguauagg gucag 15

＜210＞ 2033<210> 2033

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2033<400> 2033

auagggucag cgguu 15auagggucag cgguu 15

＜210＞ 2034<210> 2034

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2034<400> 2034

cagcgguugu cuccu 15cagcgguugu cuccu 15

＜210＞ 2035<210> 2035

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2035<400> 2035

cgguugucuc cuuug 15cgguugucuc cuuug 15

＜210＞ 2036<210> 2036

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2036<400> 2036

guugucuccu uugug 15guugucuccu uugug 15

＜210＞ 2037<210> 2037

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2037<400> 2037

gucuccuuug ugauc 15gucuccuuug ugauc 15

＜210＞ 2038<210> 2038

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2038<400> 2038

ucuccuuugu gauca 15ucuccuuugu gauca 15

＜210＞ 2039<210> 2039

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2039<400> 2039

uugugaucaa auggg 15uugugaucaa auggg 15

＜210＞ 2040<210> 2040

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2040<400> 2040

ugggaguaua ucgug 15ugggaguaua ucgug 15

＜210＞ 2041<210> 2041

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2041<400> 2041

ggaguauauc guguu 15ggaguauauc guguu 15

＜210＞ 2042<210> 2042

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2042<400> 2042

aguauaucgu guugc 15aguauaucgu guugc 15

＜210＞ 2043<210> 2043

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2043<400> 2043

aucguguugc uuuuc 15aucguguugc uuuuc 15

＜210＞ 2044<210> 2044

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2044<400> 2044

uguugcuuuu ccuuc 15uguugcuuuu ccuuc 15

＜210＞ 2045<210> 2045

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2045<400> 2045

guugcuuuuc cuucu 15guugcuuuuc cuucu 15

＜210＞ 2046<210> 2046

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2046<400> 2046

uugcuuuucc uucuc 15uugcuuuucc uucuc 15

＜210＞ 2047<210> 2047

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2047<400> 2047

ugcuuuuccu ucucc 15ugcuuuuccu ucucc 15

＜210＞ 2048<210> 2048

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2048<400> 2048

uuuuccuucu ccugg 15uuuuccuucu ccugg 15

＜210＞ 2049<210> 2049

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2049<400> 2049

uuuccuucuc cuggc 15uuuccuucuc cuggc 15

＜210＞ 2050<210> 2050

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2050<400> 2050

uccuucuccu ggcgg 15uccuucuccu ggcgg 15

＜210＞ 2051<210> 2051

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2051<400> 2051

gccugcuugu ggaug 15gccugcuugu ggaug 15

＜210＞ 2052<210> 2052

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2052<400> 2052

ugcugauagc ccagg 15ugcugauagc ccagg 15

＜210＞ 2053<210> 2053

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2053<400> 2053

gcggcguccc uggcc 15gcggcguccc uggcc 15

＜210＞ 2054<210> 2054

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2054<400> 2054

auggcauucu cuccu 15auggcauucu cuccu 15

＜210＞ 2055<210> 2055

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2055<400> 2055

uggcauucuc uccuu 15uggcauucuc uccuu 15

＜210＞ 2056<210> 2056

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2056<400> 2056

gcauucucuc cuucc 15gcauucucuc cuucc 15

＜210＞ 2057<210> 2057

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2057<400> 2057

auucucuccu uccuu 15auucucuccu uccuu 15

＜210＞ 2058<210> 2058

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2058<400> 2058

cucuccuucc uugug 15cucuccuucc uugug 15

＜210＞ 2059<210> 2059

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2059<400> 2059

ucuccuuccu ugugu 15ucuccuuccu ugugu 15

＜210＞ 2060<210> 2060

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2060<400> 2060

ccuuccuugu guuuu 15ccuuccuugu guuuu 15

＜210＞ 2061<210> 2061

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2061<400> 2061

cuuguguuuu ucugu 15cuuguguuuu ucugu 15

＜210＞ 2062<210> 2062

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2062<400> 2062

uuguguuuuu cugug 15uuguguuuuu cugug 15

＜210＞ 2063<210> 2063

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2063<400> 2063

uguguuuuuc ugugc 15uguguuuuuc ugugc 15

＜210＞ 2064<210> 2064

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2064<400> 2064

guguuuuucu gugcc 15guguuuuucu gugcc 15

＜210＞ 2065<210> 2065

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2065<400> 2065

uguuuuucug ugccg 15uguuuuucug ugccg 15

＜210＞ 2066<210> 2066

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2066<400> 2066

cgcugcuccu gcucc 15cgcugcuccu gcucc 15

＜210＞ 2067<210> 2067

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2067<400> 2067

cuggcguuac cacca 15cuggcguuac cacca 15

＜210＞ 2068<210> 2068

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2068<400> 2068

uggcguuacc accac 15uggcguuacc accac 15

＜210＞ 2069<210> 2069

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2069<400> 2069

gcugcaucgu gugga 15gcugcaucgu gugga 15

＜210＞ 2070<210> 2070

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2070<400> 2070

gggugguuuu uguag 15gggugguuuu uguag 15

＜210＞ 2071<210> 2071

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2071<400> 2071

ggugguuuuu guagg 15ggugguuuuu guagg 15

＜210＞ 2072<210> 2072

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2072<400> 2072

gugguuuuug uaggu 15gugguuuuug uaggu 15

＜210＞ 2073<210> 2073

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2073<400> 2073

ugguuuuugu agguc 15ugguuuuugu agguc 15

＜210＞ 2074<210> 2074

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2074<400> 2074

uuuuuguagg ucuaa 15uuuuuguagg ucuaa 15

＜210＞ 2075<210> 2075

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2075<400> 2075

uguaggucua auacu 15uguaggucua auacu 15

＜210＞ 2076<210> 2076

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2076<400> 2076

uaggucuaau acucu 15uaggucuaau acucu 15

＜210＞ 2077<210> 2077

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2077<400> 2077

gucuaauacu cuuga 15gucuaauacu cuuga 15

＜210＞ 2078<210> 2078

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2078<400> 2078

uaauacucuu gaccu 15uaauacucuu gaccu 15

＜210＞ 2079<210> 2079

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2079<400> 2079

auacucuuga ccuug 15auacucuuga ccuug 15

＜210＞ 2080<210> 2080

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2080<400> 2080

uugaccuugu cacca 15uugaccuugu cacca 15

＜210＞ 2081<210> 2081

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2081<400> 2081

accuugucac cacac 15accuugucac cacac 15

＜210＞ 2082<210> 2082

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2082<400> 2082

ccacacuaca aagug 15ccacacuaca aagug 15

＜210＞ 2083<210> 2083

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2083<400> 2083

aaaguguucc ucgcc 15aaaguguucc ucgcc 15

＜210＞ 2084<210> 2084

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2084<400> 2084

aaguguuccu cgcca 15aaguguuccu cgcca 15

＜210＞ 2085<210> 2085

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2085<400> 2085

uguuccucgc caggc 15uguuccucgc caggc 15

＜210＞ 2086<210> 2086

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2086<400> 2086

ccaggcucau auggu 15ccaggcucau auggu 15

＜210＞ 2087<210> 2087

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2087<400> 2087

ggcucauaug guggu 15ggcucauaug guggu 15

＜210＞ 2088<210> 2088

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2088<400> 2088

auacuuuauc accag 15auacuuuauc accag 15

＜210＞ 2089<210> 2089

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2089<400> 2089

acuuuaucac caggg 15acuuuaucac caggg 15

＜210＞ 2090<210> 2090

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2090<400> 2090

cagagcuaau cuuug 15cagagcuaau cuuug 15

＜210＞ 2091<210> 2091

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2091<400> 2091

agcuaaucuu ugaca 15agcuaaucuu ugaca 15

＜210＞ 2092<210> 2092

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2092<400> 2092

cuaaucuuug acauu 15cuaaucuuug acauu 15

＜210＞ 2093<210> 2093

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2093<400> 2093

uaaucuuuga cauua 15uaaucuuuga cauua 15

＜210＞ 2094<210> 2094

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2094<400> 2094

uugacauuac caaac 15uugacauuac caaac 15

＜210＞ 2095<210> 2095

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2095<400> 2095

ugacauuacc aaacu 15ugacauuacc aaacu 15

＜210＞ 2096<210> 2096

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2096<400> 2096

ccaaacuccu gcucg 15ccaaacuccu gcucg 15

＜210＞ 2097<210> 2097

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2097<400> 2097

uccugcucgc cauuc 15uccugcucgc cauuc 15

＜210＞ 2098<210> 2098

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2098<400> 2098

ucgccauucu cgguc 15ucgccauucu cgguc 15

＜210＞ 2099<210> 2099

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2099<400> 2099

cgccauucuc ggucc 15cgccauucuc ggucc 15

＜210＞ 2100<210> 2100

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2100<400> 2100

ccauucucgg uccgc 15ccauucucgg uccgc 15

＜210＞ 2101<210> 2101

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2101<400> 2101

ucucgguccg cucau 15ucucgguccg cucau 15

＜210＞ 2102<210> 2102

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2102<400> 2102

guccgcucau ggugc 15guccgcucau ggugc 15

＜210＞ 2103<210> 2103

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2103<400> 2103

uggugcucca ggcug 15uggugcucca ggcug 15

＜210＞ 2104<210> 2104

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2104<400> 2104

augccguacu uugua 15augccguacu uugua 15

＜210＞ 2105<210> 2105

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2105<400> 2105

ccguacuuug uacgc 15ccguacuuug uacgc 15

＜210＞ 2106<210> 2106

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2106<400> 2106

cguacuuugu acgcg 15cguacuuugu acgcg 15

＜210＞ 2107<210> 2107

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2107<400> 2107

acuuuguacg cgcuc 15acuuuguacg cgcuc 15

＜210＞ 2108<210> 2108

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2108<400> 2108

acgcgcucag gggcu 15acgcgcucag gggcu 15

＜210＞ 2109<210> 2109

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2109<400> 2109

aggggcuuau ucgug 15aggggcuuau ucgug 15

＜210＞ 2110<210> 2110

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2110<400> 2110

ggggcuuauu cgugc 15ggggcuuauu cgugc 15

＜210＞ 2111<210> 2111

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2111<400> 2111

ggcuuauucg ugcau 15ggcuuauucg ugcau 15

＜210＞ 2112<210> 2112

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2112<400> 2112

gcuuauucgu gcaug 15gcuuauucgu gcaug 15

＜210＞ 2113<210> 2113

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2113<400> 2113

ugcauguugg ugcgg 15ugcauguugg ugcgg 15

＜210＞ 2114<210> 2114

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2114<400> 2114

ggaaaguagc cggag 15ggaaaguagc cggag 15

＜210＞ 2115<210> 2115

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2115<400> 2115

gacagguacg uacgu 15gacagguacg uacgu 15

＜210＞ 2116<210> 2116

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2116<400> 2116

gguacguacg ucuau 15gguacguacg ucuau 15

＜210＞ 2117<210> 2117

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2117<400> 2117

cguacgucua ugacc 15cguacgucua ugacc 15

＜210＞ 2118<210> 2118

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2118<400> 2118

uacgucuaug accau 15uacgucuaug accau 15

＜210＞ 2119<210> 2119

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2119<400> 2119

ugaccaucuu acccc 15ugaccaucuu acccc 15

＜210＞ 2120<210> 2120

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2120<400> 2120

accaucuuac cccgc 15accaucuuac cccgc 15

＜210＞ 2121<210> 2121

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2121<400> 2121

ccaucuuacc ccgcu 15ccaucuuacc ccgcu 15

＜210＞ 2122<210> 2122

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2122<400> 2122

uggcaguaga gcccg 15uggcaguaga gcccg 15

＜210＞ 2123<210> 2123

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2123<400> 2123

ucgucuucuc ugaca 15ucgucuucuc ugaca 15

＜210＞ 2124<210> 2124

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2124<400> 2124

gucuucucug acaug 15gucuucucug acaug 15

＜210＞ 2125<210> 2125

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2125<400> 2125

agauacuucu gggac 15agauacuucu gggac 15

＜210＞ 2126<210> 2126

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2126<400> 2126

gauacuucug ggacc 15gauacuucug ggacc 15

＜210＞ 2127<210> 2127

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2127<400> 2127

ggccgauagc auuga 15ggccgauagc auuga 15

＜210＞ 2128<210> 2128

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2128<400> 2128

auagcauuga agggc 15auagcauuga agggc 15

＜210＞ 2129<210> 2129

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2129<400> 2129

acggccuacg cccaa 15acggccuacg cccaa 15

＜210＞ 2130<210> 2130

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2130<400> 2130

ggggccuacu ugguu 15ggggccuacu ugguu 15

＜210＞ 2131<210> 2131

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2131<400> 2131

gccuacuugg uugca 15gccuacuugg uugca 15

＜210＞ 2132<210> 2132

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2132<400> 2132

acuugguugc auugu 15acuugguugc auugu 15

＜210＞ 2133<210> 2133

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2133<400> 2133

guugcauugu uacua 15guugcauugu uacua 15

＜210＞ 2134<210> 2134

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2134<400> 2134

gcauuguuac uagcc 15gcauuguuac uagcc 15

＜210＞ 2135<210> 2135

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2135<400> 2135

cauuguuacu agccu 15cauuguuacu agccu 15

＜210＞ 2136<210> 2136

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2136<400> 2136

uguuacuagc cucac 15uguuacuagc cucac 15

＜210＞ 2137<210> 2137

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2137<400> 2137

accaggucga agggg 15accaggucga agggg 15

＜210＞ 2138<210> 2138

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2138<400> 2138

acacaaucuu uccug 15acacaaucuu uccug 15

＜210＞ 2139<210> 2139

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2139<400> 2139

acaaucuuuc cuggc 15acaaucuuuc cuggc 15

＜210＞ 2140<210> 2140

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2140<400> 2140

caaucuuucc uggcg 15caaucuuucc uggcg 15

＜210＞ 2141<210> 2141

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2141<400> 2141

aaucuuuccu ggcga 15aaucuuuccu ggcga 15

＜210＞ 2142<210> 2142

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2142<400> 2142

ccugcguuaa uggug 15ccugcguuaa uggug 15

＜210＞ 2143<210> 2143

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2143<400> 2143

cugcguuaau ggugu 15cugcguuaau ggugu 15

＜210＞ 2144<210> 2144

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2144<400> 2144

ggaccgucuu ccacg 15ggaccgucuu ccacg 15

＜210＞ 2145<210> 2145

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2145<400> 2145

accgucuucc acggc 15accgucuucc acggc 15

＜210＞ 2146<210> 2146

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2146<400> 2146

ccgucuucca cggcg 15ccgucuucca cggcg 15

＜210＞ 2147<210> 2147

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2147<400> 2147

gcccaaucac ccaaa 15gcccaaucac ccaaa 15

＜210＞ 2148<210> 2148

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2148<400> 2148

caaauguaca cuaau 15caaauguaca cuaau 15

＜210＞ 2149<210> 2149

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2149<400> 2149

guacacuaau guaga 15guacacuaau guaga 15

＜210＞ 2150<210> 2150

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2150<400> 2150

cuaauguaga ccaag 15cuaauguaga ccaag 15

＜210＞ 2151<210> 2151

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2151<400> 2151

aagaccucgu cggcu 15aagaccucgu cggcu 15

＜210＞ 2152<210> 2152

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2152<400> 2152

accucgucgg cuggc 15accucgucgg cuggc 15

＜210＞ 2153<210> 2153

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2153<400> 2153

cugcgguagc ucgga 15cugcgguagc ucgga 15

＜210＞ 2154<210> 2154

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2154<400> 2154

cugacgucau uccgg 15cugacgucau uccgg 15

＜210＞ 2155<210> 2155

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2155<400> 2155

gacccgucuc cuauu 15gacccgucuc cuauu 15

＜210＞ 2156<210> 2156

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2156<400> 2156

cccgucuccu auuug 15cccgucuccu auuug 15

＜210＞ 2157<210> 2157

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2157<400> 2157

gucuccuauu ugaag 15gucuccuauu ugaag 15

＜210＞ 2158<210> 2158

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2158<400> 2158

cuccuauuug aaggg 15cuccuauuug aaggg 15

＜210＞ 2159<210> 2159

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2159<400> 2159

uccuauuuga agggc 15uccuauuuga agggc 15

＜210＞ 2160<210> 2160

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2160<400> 2160

aagggcucuu cgggu 15aagggcucuu cgggu 15

＜210＞ 2161<210> 2161

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2161<400> 2161

gggcucuucg ggugg 15gggcucuucg ggugg 15

＜210＞ 2162<210> 2162

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2162<400> 2162

guggacuuca uaccc 15guggacuuca uaccc 15

＜210＞ 2163<210> 2163

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2163<400> 2163

uggacuucau acccg 15uggacuucau acccg 15

＜210＞ 2164<210> 2164

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2164<400> 2164

acuucauacc cguug 15acuucauacc cguug 15

＜210＞ 2165<210> 2165

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2165<400> 2165

uacccguuga gucua 15uacccguuga gucua 15

＜210＞ 2166<210> 2166

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2166<400> 2166

guugagucua uggaa 15guugagucua uggaa 15

＜210＞ 2167<210> 2167

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2167<400> 2167

ugagucuaug gaaac 15ugagucuaug gaaac 15

＜210＞ 2168<210> 2168

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2168<400> 2168

ggaaacuacu augcg 15ggaaacuacu augcg 15

＜210＞ 2169<210> 2169

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2169<400> 2169

aacuacuaug cgguc 15aacuacuaug cgguc 15

＜210＞ 2170<210> 2170

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2170<400> 2170

augcgguccc cgguc 15augcgguccc cgguc 15

＜210＞ 2171<210> 2171

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2171<400> 2171

ccccggucuu cacgg 15ccccggucuu cacgg 15

＜210＞ 2172<210> 2172

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2172<400> 2172

ccggucuuca cggac 15ccggucuuca cggac 15

＜210＞ 2173<210> 2173

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2173<400> 2173

cggucuucac ggaca 15cggucuucac ggaca 15

＜210＞ 2174<210> 2174

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2174<400> 2174

gacaacucau cuccc 15gacaacucau cuccc 15

＜210＞ 2175<210> 2175

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2175<400> 2175

aacucaucuc ccccg 15aacucaucuc ccccg 15

＜210＞ 2176<210> 2176

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2176<400> 2176

cucaucuccc ccggc 15cucaucuccc ccggc 15

＜210＞ 2177<210> 2177

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2177<400> 2177

cggccguacc gcaga 15cggccguacc gcaga 15

＜210＞ 2178<210> 2178

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2178<400> 2178

cagacauucc aagug 15cagacauucc aagug 15

＜210＞ 2179<210> 2179

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2179<400> 2179

agacauucca agugg 15agacauucca agugg 15

＜210＞ 2180<210> 2180

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2180<400> 2180

ggcccaucua cacgc 15ggcccaucua cacgc 15

＜210＞ 2181<210> 2181

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2181<400> 2181

cccaucuaca cgcuc 15cccaucuaca cgcuc 15

＜210＞ 2182<210> 2182

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2182<400> 2182

acacgcuccc acugg 15acacgcuccc acugg 15

＜210＞ 2183<210> 2183

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2183<400> 2183

acaagguacu cgucc 15acaagguacu cgucc 15

＜210＞ 2184<210> 2184

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2184<400> 2184

agguacucgu ccuga 15agguacucgu ccuga 15

＜210＞ 2185<210> 2185

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2185<400> 2185

uacucguccu gaacc 15uacucguccu gaacc 15

＜210＞ 2186<210> 2186

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2186<400> 2186

aacccaucug uugcc 15aacccaucug uugcc 15

＜210＞ 2187<210> 2187

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2187<400> 2187

gccaccuugg guuuu 15gccaccuugg guuuu 15

＜210＞ 2188<210> 2188

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2188<400> 2188

cuuggguuuu ggggc 15cuuggguuuu ggggc 15

＜210＞ 2189<210> 2189

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2189<400> 2189

uuggguuuug gggcg 15uuggguuuug gggcg 15

＜210＞ 2190<210> 2190

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2190<400> 2190

uggguuuugg ggcgu 15uggguuuugg ggcgu 15

＜210＞ 2191<210> 2191

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2191<400> 2191

ggggcguaua ugucu 15ggggcguaua ugucu 15

＜210＞ 2192<210> 2192

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2192<400> 2192

ggcguauaug ucuaa 15ggcguauaug ucuaa 15

＜210＞ 2193<210> 2193

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2193<400> 2193

uauaugucua aggca 15uauaugucua aggca 15

＜210＞ 2194<210> 2194

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2194<400> 2194

uaugucuaag gcaca 15uaugucuaag gcaca 15

＜210＞ 2195<210> 2195

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2195<400> 2195

acaugguacc gaccc 15acaugguacc gaccc 15

＜210＞ 2196<210> 2196

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2196<400> 2196

ggaccauuac cacgg 15ggaccauuac cacgg 15

＜210＞ 2197<210> 2197

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2197<400> 2197

gaccauuacc acggg 15gaccauuacc acggg 15

＜210＞ 2198<210> 2198

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2198<400> 2198

cccccaucac guacu 15cccccaucac guacu 15

＜210＞ 2199<210> 2199

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2199<400> 2199

aucacguacu ccacc 15aucacguacu ccacc 15

＜210＞ 2200<210> 2200

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2200<400> 2200

acguacucca ccuau 15acguacucca ccuau 15

＜210＞ 2201<210> 2201

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2201<400> 2201

uggauguucu ggggg 15uggauguucu ggggg 15

＜210＞ 2202<210> 2202

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2202<400> 2202

ggauguucug ggggc 15ggauguucug ggggc 15

＜210＞ 2203<210> 2203

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2203<400> 2203

ggcgccuaug auauc 15ggcgccuaug auauc 15

＜210＞ 2204<210> 2204

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2204<400> 2204

cuaugauauc auaau 15cuaugauauc auaau 15

＜210＞ 2205<210> 2205

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2205<400> 2205

augauaucau aauau 15augauaucau aauau 15

＜210＞ 2206<210> 2206

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2206<400> 2206

ugccacucaa cugac 15ugccacucaa cugac 15

＜210＞ 2207<210> 2207

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2207<400> 2207

acugacucga cuacc 15acugacucga cuacc 15

＜210＞ 2208<210> 2208

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2208<400> 2208

cucgacuacc auccu 15cucgacuacc auccu 15

＜210＞ 2209<210> 2209

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2209<400> 2209

cuaccauccu gggca 15cuaccauccu gggca 15

＜210＞ 2210<210> 2210

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2210<400> 2210

ugggcaucgg cacag 15ugggcaucgg cacag 15

＜210＞ 2211<210> 2211

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2211<400> 2211

caccgcuacg ccucc 15caccgcuacg ccucc 15

＜210＞ 2212<210> 2212

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2212<400> 2212

uacgccuccg ggauc 15uacgccuccg ggauc 15

＜210＞ 2213<210> 2213

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2213<400> 2213

ccgggaucgg uuacc 15ccgggaucgg uuacc 15

＜210＞ 2214<210> 2214

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2214<400> 2214

gaucgguuac cgugc 15gaucgguuac cgugc 15

＜210＞ 2215<210> 2215

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2215<400> 2215

aucgguuacc gugcc 15aucgguuacc gugcc 15

＜210＞ 2216<210> 2216

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2216<400> 2216

caaauauuga ggagg 15caaauauuga ggagg 15

＜210＞ 2217<210> 2217

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2217<400> 2217

gguggcucug uccaa 15gguggcucug uccaa 15

＜210＞ 2218<210> 2218

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2218<400> 2218

auccccuucu auggc 15auccccuucu auggc 15

＜210＞ 2219<210> 2219

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2219<400> 2219

uccccuucua uggca 15uccccuucua uggca 15

＜210＞ 2220<210> 2220

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2220<400> 2220

cccuucuaug gcaag 15cccuucuaug gcaag 15

＜210＞ 2221<210> 2221

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2221<400> 2221

aaggcaucuc auuuu 15aaggcaucuc auuuu 15

＜210＞ 2222<210> 2222

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2222<400> 2222

ggcaucucau uuucu 15ggcaucucau uuucu 15

＜210＞ 2223<210> 2223

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2223<400> 2223

aucucauuuu cugcc 15aucucauuuu cugcc 15

＜210＞ 2224<210> 2224

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2224<400> 2224

ucucauuuuc ugcca 15ucucauuuuc ugcca 15

＜210＞ 2225<210> 2225

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2225<400> 2225

cucauuuucu gccac 15cucauuuucu gccac 15

＜210＞ 2226<210> 2226

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2226<400> 2226

ucauuuucug ccacu 15ucauuuucug ccacu 15

＜210＞ 2227<210> 2227

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2227<400> 2227

augagcucgc cgcaa 15augagcucgc cgcaa 15

＜210＞ 2228<210> 2228

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2228<400> 2228

aagcugucag gccuc 15aagcugucag gccuc 15

＜210＞ 2229<210> 2229

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2229<400> 2229

caggccucgg aauca 15caggccucgg aauca 15

＜210＞ 2230<210> 2230

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2230<400> 2230

ccggggucuu gacgu 15ccggggucuu gacgu 15

＜210＞ 2231<210> 2231

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2231<400> 2231

ggggucuuga cgugu 15ggggucuuga cgugu 15

＜210＞ 2232<210> 2232

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2232<400> 2232

gacguguccg ucaua 15gacguguccg ucaua 15

＜210＞ 2233<210> 2233

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2233<400> 2233

gagaugucgu uaucg 15gagaugucgu uaucg 15

＜210＞ 2234<210> 2234

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2234<400> 2234

augucguuau cgugg 15augucguuau cgugg 15

＜210＞ 2235<210> 2235

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2235<400> 2235

ugucguuauc guggc 15ugucguuauc guggc 15

＜210＞ 2236<210> 2236

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2236<400> 2236

ucguuaucgu ggcaa 15ucguuaucgu ggcaa 15

＜210＞ 2237<210> 2237

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2237<400> 2237

agacgcucua augac 15agacgcucua augac 15

＜210＞ 2238<210> 2238

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2238<400> 2238

acgcucuaau gacgg 15acgcucuaau gacgg 15

＜210＞ 2239<210> 2239

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2239<400> 2239

ggugacuuug acucg 15ggugacuuug acucg 15

＜210＞ 2240<210> 2240

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2240<400> 2240

gugacuuuga cucgg 15gugacuuuga cucgg 15

＜210＞ 2241<210> 2241

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2241<400> 2241

uuugacucgg ugauc 15uuugacucgg ugauc 15

＜210＞ 2242<210> 2242

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2242<400> 2242

caugugucac ccaga 15caugugucac ccaga 15

＜210＞ 2243<210> 2243

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2243<400> 2243

agacagucga uuuca 15agacagucga uuuca 15

＜210＞ 2244<210> 2244

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2244<400> 2244

agucgauuuc agcuu 15agucgauuuc agcuu 15

＜210＞ 2245<210> 2245

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2245<400> 2245

gucgauuuca gcuug 15gucgauuuca gcuug 15

＜210＞ 2246<210> 2246

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2246<400> 2246

ucgauuucag cuugg 15ucgauuucag cuugg 15

＜210＞ 2247<210> 2247

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2247<400> 2247

uucagcuugg auccc 15uucagcuugg auccc 15

＜210＞ 2248<210> 2248

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2248<400> 2248

cuuggauccc accuu 15cuuggauccc accuu 15

＜210＞ 2249<210> 2249

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2249<400> 2249

cccaccuuua ccauu 15cccaccuuua ccauu 15

＜210＞ 2250<210> 2250

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2250<400> 2250

ccaccuuuac cauug 15ccaccuuuac cauug 15

＜210＞ 2251<210> 2251

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2251<400> 2251

caccuuuacc auuga 15caccuuuacc auuga 15

＜210＞ 2252<210> 2252

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2252<400> 2252

uuaccauuga gacga 15uuaccauuga gacga 15

＜210＞ 2253<210> 2253

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2253<400> 2253

cagggguagg ggagg 15cagggguagg ggagg 15

＜210＞ 2254<210> 2254

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2254<400> 2254

gaggcaucua caggu 15gaggcaucua caggu 15

＜210＞ 2255<210> 2255

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2255<400> 2255

ggcaucuaca gguuu 15ggcaucuaca gguuu 15

＜210＞ 2256<210> 2256

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2256<400> 2256

uacagguuug ugacu 15uacagguuug ugacu 15

＜210＞ 2257<210> 2257

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2257<400> 2257

acagguuugu gacuc 15acagguuugu gacuc 15

＜210＞ 2258<210> 2258

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2258<400> 2258

ugugacuccg ggaga 15ugugacuccg ggaga 15

＜210＞ 2259<210> 2259

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2259<400> 2259

cggcccucgg gcaug 15cggcccucgg gcaug 15

＜210＞ 2260<210> 2260

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2260<400> 2260

ggcauguucg auucu 15ggcauguucg auucu 15

＜210＞ 2261<210> 2261

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2261<400> 2261

gcauguucga uucuu 15gcauguucga uucuu 15

＜210＞ 2262<210> 2262

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2262<400> 2262

guucgauucu ucggu 15guucgauucu ucggu 15

＜210＞ 2263<210> 2263

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2263<400> 2263

uucgauucuu cgguc 15uucgauucuu cgguc 15

＜210＞ 2264<210> 2264

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2264<400> 2264

cgauucuucg guccu 15cgauucuucg guccu 15

＜210＞ 2265<210> 2265

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2265<400> 2265

gauucuucgg uccug 15gauucuucgg uccug 15

＜210＞ 2266<210> 2266

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2266<400> 2266

cuucgguccu gugug 15cuucgguccu gugug 15

＜210＞ 2267<210> 2267

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2267<400> 2267

gagugcuaug acgcg 15gagugcuaug acgcg 15

＜210＞ 2268<210> 2268

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2268<400> 2268

cuggaguucu gggaa 15cuggaguucu gggaa 15

＜210＞ 2269<210> 2269

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2269<400> 2269

uggaguucug ggaaa 15uggaguucug ggaaa 15

＜210＞ 2270<210> 2270

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2270<400> 2270

aaagcgucuu cacag 15aaagcgucuu cacag 15

＜210＞ 2271<210> 2271

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2271<400> 2271

agcgucuuca caggc 15agcgucuuca caggc 15

＜210＞ 2272<210> 2272

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2272<400> 2272

gcgucuucac aggcc 15gcgucuucac aggcc 15

＜210＞ 2273<210> 2273

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2273<400> 2273

caggccucac ccaca 15caggccucac ccaca 15

＜210＞ 2274<210> 2274

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2274<400> 2274

cccacauaga ugccc 15cccacauaga ugccc 15

＜210＞ 2275<210> 2275

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2275<400> 2275

gcccacuucc ugucc 15gcccacuucc ugucc 15

＜210＞ 2276<210> 2276

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2276<400> 2276

cccacuuccu guccc 15cccacuuccu guccc 15

＜210＞ 2277<210> 2277

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2277<400> 2277

uuccuguccc aaacc 15uuccuguccc aaacc 15

＜210＞ 2278<210> 2278

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2278<400> 2278

gacaacuucc cuuac 15gacaacuucc cuuac 15

＜210＞ 2279<210> 2279

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2279<400> 2279

acaacuuccc uuacc 15acaacuuccc uuacc 15

＜210＞ 2280<210> 2280

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2280<400> 2280

cuucccuuac cuggu 15cuucccuuac cuggu 15

＜210＞ 2281<210> 2281

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2281<400> 2281

uucccuuacc uggua 15uucccuuacc uggua 15

＜210＞ 2282<210> 2282

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2282<400> 2282

ucaggcucca ccucc 15ucaggcucca ccucc 15

＜210＞ 2283<210> 2283

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2283<400> 2283

uccaccucca ucgug 15uccaccucca ucgug 15

＜210＞ 2284<210> 2284

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2284<400> 2284

ccuccaucgu gggau 15ccuccaucgu gggau 15

＜210＞ 2285<210> 2285

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2285<400> 2285

gugggaucaa augug 15gugggaucaa augug 15

＜210＞ 2286<210> 2286

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2286<400> 2286

gaagugucuc auacg 15gaagugucuc auacg 15

＜210＞ 2287<210> 2287

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2287<400> 2287

agugucucau acggc 15agugucucau acggc 15

＜210＞ 2288<210> 2288

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2288<400> 2288

gucucauacg gcuua 15gucucauacg gcuua 15

＜210＞ 2289<210> 2289

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2289<400> 2289

uacggcuuaa accua 15uacggcuuaa accua 15

＜210＞ 2290<210> 2290

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2290<400> 2290

acggcuuaaa ccuac 15acggcuuaaa ccuac 15

＜210＞ 2291<210> 2291

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2291<400> 2291

uaaaccuacg cugca 15uaaaccuacg cugca 15

＜210＞ 2292<210> 2292

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2292<400> 2292

auaggcuagg agccg 15auaggcuagg agccg 15

＜210＞ 2293<210> 2293

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2293<400> 2293

gagccguuca aaaug 15gagccguuca aaaug 15

＜210＞ 2294<210> 2294

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2294<400> 2294

agccguucaa aauga 15agccguucaa aauga 15

＜210＞ 2295<210> 2295

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2295<400> 2295

augagaucac ccuca 15augagaucac ccuca 15

＜210＞ 2296<210> 2296

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2296<400> 2296

ucacccucac acauc 15ucacccucac acauc 15

＜210＞ 2297<210> 2297

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2297<400> 2297

cacacauccc auaac 15cacacauccc auaac 15

＜210＞ 2298<210> 2298

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2298<400> 2298

aucccauaac caaau 15aucccauaac caaau 15

＜210＞ 2299<210> 2299

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2299<400> 2299

accaaauuca ucaug 15accaaauuca ucaug 15

＜210＞ 2300<210> 2300

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2300<400> 2300

ccaaauucau caugg 15ccaaauucau caugg 15

＜210＞ 2301<210> 2301

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2301<400> 2301

aauucaucau ggcau 15aauucaucau ggcau 15

＜210＞ 2302<210> 2302

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2302<400> 2302

ugcaugucgg ccgac 15ugcaugucgg ccgac 15

＜210＞ 2303<210> 2303

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2303<400> 2303

ugcagcucug gccgc 15ugcagcucug gccgc 15

＜210＞ 2304<210> 2304

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2304<400> 2304

guguggucau ugugg 15guguggucau ugugg 15

＜210＞ 2305<210> 2305

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2305<400> 2305

uggucauugu gggua 15uggucauugu gggua 15

＜210＞ 2306<210> 2306

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2306<400> 2306

uguggguagg aucau 15uguggguagg aucau 15

＜210＞ 2307<210> 2307

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2307<400> 2307

ggaucauuuu guccg 15ggaucauuuu guccg 15

＜210＞ 2308<210> 2308

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2308<400> 2308

gaucauuuug uccgg 15gaucauuuug uccgg 15

＜210＞ 2309<210> 2309

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2309<400> 2309

aucauuuugu ccggg 15aucauuuugu ccggg 15

＜210＞ 2310<210> 2310

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2310<400> 2310

auuuuguccg ggagg 15auuuuguccg ggagg 15

＜210＞ 2311<210> 2311

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2311<400> 2311

gggaaguccu cuacc 15gggaaguccu cuacc 15

＜210＞ 2312<210> 2312

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2312<400> 2312

aaguccucua ccggg 15aaguccucua ccggg 15

＜210＞ 2313<210> 2313

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2313<400> 2313

guccucuacc gggag 15guccucuacc gggag 15

＜210＞ 2314<210> 2314

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2314<400> 2314

cgggaguucg augaa 15cgggaguucg augaa 15

＜210＞ 2315<210> 2315

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2315<400> 2315

gggaguucga ugaaa 15gggaguucga ugaaa 15

＜210＞ 2316<210> 2316

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2316<400> 2316

ugcgccucac accuc 15ugcgccucac accuc 15

＜210＞ 2317<210> 2317

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2317<400> 2317

cacaccuccc uuaca 15cacaccuccc uuaca 15

＜210＞ 2318<210> 2318

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2318<400> 2318

ccucccuuac aucga 15ccucccuuac aucga 15

＜210＞ 2319<210> 2319

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2319<400> 2319

cucccuuaca ucgaa 15cucccuuaca ucgaa 15

＜210＞ 2320<210> 2320

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2320<400> 2320

cuuacaucga acagg 15cuuacaucga acagg 15

＜210＞ 2321<210> 2321

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2321<400> 2321

ugcagcucgc cgagc 15ugcagcucgc cgagc 15

＜210＞ 2322<210> 2322

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2322<400> 2322

aggcacucgg guugc 15aggcacucgg guugc 15

＜210＞ 2323<210> 2323

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2323<400> 2323

cucggguugc ugcaa 15cucggguugc ugcaa 15

＜210＞ 2324<210> 2324

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2324<400> 2324

uggaacuuca ucagc 15uggaacuuca ucagc 15

＜210＞ 2325<210> 2325

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2325<400> 2325

ggaacuucau cagcg 15ggaacuucau cagcg 15

＜210＞ 2326<210> 2326

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2326<400> 2326

acuucaucag cggga 15acuucaucag cggga 15

＜210＞ 2327<210> 2327

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2327<400> 2327

gcgggauaca guauu 15gcgggauaca guauu 15

＜210＞ 2328<210> 2328

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2328<400> 2328

auacaguauu uagca 15auacaguauu uagca 15

＜210＞ 2329<210> 2329

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2329<400> 2329

acaguauuua gcagg 15acaguauuua gcagg 15

＜210＞ 2330<210> 2330

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2330<400> 2330

caguauuuag caggc 15caguauuuag caggc 15

＜210＞ 2331<210> 2331

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2331<400> 2331

aguauuuagc aggcu 15aguauuuagc aggcu 15

＜210＞ 2332<210> 2332

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2332<400> 2332

ggcuuaucca cucug 15ggcuuaucca cucug 15

＜210＞ 2333<210> 2333

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2333<400> 2333

auccacucug ccugg 15auccacucug ccugg 15

＜210＞ 2334<210> 2334

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2334<400> 2334

ccgcgauagc aucac 15ccgcgauagc aucac 15

＜210＞ 2335<210> 2335

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2335<400> 2335

auagcaucac ugaug 15auagcaucac ugaug 15

＜210＞ 2336<210> 2336

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2336<400> 2336

auggcauuca cagcc 15auggcauuca cagcc 15

＜210＞ 2337<210> 2337

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2337<400> 2337

uggcauucac agccu 15uggcauucac agccu 15

＜210＞ 2338<210> 2338

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2338<400> 2338

acagccucua ucacc 15acagccucua ucacc 15

＜210＞ 2339<210> 2339

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2339<400> 2339

agccucuauc accag 15agccucuauc accag 15

＜210＞ 2340<210> 2340

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2340<400> 2340

ccucuaucac caguc 15ccucuaucac caguc 15

＜210＞ 2341<210> 2341

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2341<400> 2341

caccaguccg cucac 15caccaguccg cucac 15

＜210＞ 2342<210> 2342

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2342<400> 2342

guccgcucac caccc 15guccgcucac caccc 15

＜210＞ 2343<210> 2343

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2343<400> 2343

ccagaauacc cuccu 15ccagaauacc cuccu 15

＜210＞ 2344<210> 2344

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2344<400> 2344

auacccuccu guuca 15auacccuccu guuca 15

＜210＞ 2345<210> 2345

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2345<400> 2345

ucaacaucuu agggg 15ucaacaucuu agggg 15

＜210＞ 2346<210> 2346

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2346<400> 2346

aacaucuuag gggga 15aacaucuuag gggga 15

＜210＞ 2347<210> 2347

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2347<400> 2347

acaucuuagg gggau 15acaucuuagg gggau 15

＜210＞ 2348<210> 2348

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2348<400> 2348

ggcugcucaa cucgc 15ggcugcucaa cucgc 15

＜210＞ 2349<210> 2349

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2349<400> 2349

cgcuccuccc agugc 15cgcuccuccc agugc 15

＜210＞ 2350<210> 2350

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2350<400> 2350

ugcugcuucg gccuu 15ugcugcuucg gccuu 15

＜210＞ 2351<210> 2351

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2351<400> 2351

aggugcuugu ggaca 15aggugcuugu ggaca 15

＜210＞ 2352<210> 2352

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2352<400> 2352

uggacauucu ggcgg 15uggacauucu ggcgg 15

＜210＞ 2353<210> 2353

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2353<400> 2353

ggacauucug gcggg 15ggacauucug gcggg 15

＜210＞ 2354<210> 2354

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2354<400> 2354

guuaacuugc ucccu 15guuaacuugc ucccu 15

＜210＞ 2355<210> 2355

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2355<400> 2355

cugccauccu cuccc 15cugccauccu cuccc 15

＜210＞ 2356<210> 2356

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2356<400> 2356

ccauccucuc ccccg 15ccauccucuc ccccg 15

＜210＞ 2357<210> 2357

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2357<400> 2357

ggcugauagc guucg 15ggcugauagc guucg 15

＜210＞ 2358<210> 2358

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2358<400> 2358

uucgcuucgc ggggu 15uucgcuucgc ggggu 15

＜210＞ 2359<210> 2359

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2359<400> 2359

gcgggguaac cacgu 15gcgggguaac cacgu 15

＜210＞ 2360<210> 2360

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2360<400> 2360

accacguuuc cccca 15accacguuuc cccca 15

＜210＞ 2361<210> 2361

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2361<400> 2361

ccacguuucc cccac 15ccacguuucc cccac 15

＜210＞ 2362<210> 2362

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2362<400> 2362

cacguuuccc ccacg 15cacguuuccc ccacg 15

＜210＞ 2363<210> 2363

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2363<400> 2363

acgcacuacg ugccu 15acgcacuacg ugccu 15

＜210＞ 2364<210> 2364

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2364<400> 2364

cacguguaac ucaga 15cacguguaac ucaga 15

＜210＞ 2365<210> 2365

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2365<400> 2365

uguaacucag auccu 15uguaacucag auccu 15

＜210＞ 2366<210> 2366

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2366<400> 2366

cucagauccu cucca 15cucagauccu cucca 15

＜210＞ 2367<210> 2367

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2367<400> 2367

agauccucuc cagcc 15agauccucuc cagcc 15

＜210＞ 2368<210> 2368

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2368<400> 2368

auccucucca gccuc 15auccucucca gccuc 15

＜210＞ 2369<210> 2369

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2369<400> 2369

ccagccucac cauca 15ccagccucac cauca 15

＜210＞ 2370<210> 2370

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2370<400> 2370

ucaccaucac ucagc 15ucaccaucac ucagc 15

＜210＞ 2371<210> 2371

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2371<400> 2371

caucacucag cugcu 15caucacucag cugcu 15

＜210＞ 2372<210> 2372

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2372<400> 2372

agaggcuuca ccagu 15agaggcuuca ccagu 15

＜210＞ 2373<210> 2373

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2373<400> 2373

gaggcuucac cagug 15gaggcuucac cagug 15

＜210＞ 2374<210> 2374

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2374<400> 2374

aguggauuaa ugagg 15aguggauuaa ugagg 15

＜210＞ 2375<210> 2375

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2375<400> 2375

guggauuaau gagga 15guggauuaau gagga 15

＜210＞ 2376<210> 2376

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2376<400> 2376

gacugcucca cgcca 15gacugcucca cgcca 15

＜210＞ 2377<210> 2377

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2377<400> 2377

ccaugcuccg gcucg 15ccaugcuccg gcucg 15

＜210＞ 2378<210> 2378

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2378<400> 2378

uccggcucgu ggcua 15uccggcucgu ggcua 15

＜210＞ 2379<210> 2379

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2379<400> 2379

cguggcuaaa ggaug 15cguggcuaaa ggaug 15

＜210＞ 2380<210> 2380

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2380<400> 2380

aggauguuug ggacu 15aggauguuug ggacu 15

＜210＞ 2381<210> 2381

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2381<400> 2381

ggauguuugg gacug 15ggauguuugg gacug 15

＜210＞ 2382<210> 2382

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2382<400> 2382

acuggauaug cacgg 15acuggauaug cacgg 15

＜210＞ 2383<210> 2383

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2383<400> 2383

acgguguuga cugac 15acgguguuga cugac 15

＜210＞ 2384<210> 2384

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2384<400> 2384

acugacuuca agacc 15acugacuuca agacc 15

＜210＞ 2385<210> 2385

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2385<400> 2385

cugacuucaa gaccu 15cugacuucaa gaccu 15

＜210＞ 2386<210> 2386

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2386<400> 2386

ccuggcucca gucca 15ccuggcucca gucca 15

＜210＞ 2387<210> 2387

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2387<400> 2387

cuccagucca agcuc 15cuccagucca agcuc 15

＜210＞ 2388<210> 2388

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2388<400> 2388

ccaagcuccu gccga 15ccaagcuccu gccga 15

＜210＞ 2389<210> 2389

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2389<400> 2389

ccgaaauugc cggga 15ccgaaauugc cggga 15

＜210＞ 2390<210> 2390

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2390<400> 2390

cgggaguccc uuucu 15cgggaguccc uuucu 15

＜210＞ 2391<210> 2391

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2391<400> 2391

agucccuuuc uucuc 15agucccuuuc uucuc 15

＜210＞ 2392<210> 2392

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2392<400> 2392

gucccuuucu ucuca 15gucccuuucu ucuca 15

＜210＞ 2393<210> 2393

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2393<400> 2393

ucccuuucuu cucau 15ucccuuucuu cucau 15

＜210＞ 2394<210> 2394

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2394<400> 2394

ccuuucuucu caugc 15ccuuucuucu caugc 15

＜210＞ 2395<210> 2395

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2395<400> 2395

cuuucuucuc augcc 15cuuucuucuc augcc 15

＜210＞ 2396<210> 2396

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2396<400> 2396

uucuucucau gccaa 15uucuucucau gccaa 15

＜210＞ 2397<210> 2397

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2397<400> 2397

cgcggguaca aggga 15cgcggguaca aggga 15

＜210＞ 2398<210> 2398

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2398<400> 2398

agggagucug gcggg 15agggagucug gcggg 15

＜210＞ 2399<210> 2399

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2399<400> 2399

cacaaauuac cggac 15cacaaauuac cggac 15

＜210＞ 2400<210> 2400

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2400<400> 2400

acaaauuacc ggaca 15acaaauuacc ggaca 15

＜210＞ 2401<210> 2401

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2401<400> 2401

gacaugucaa aaacg 15gacaugucaa aaacg 15

＜210＞ 2402<210> 2402

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2402<400> 2402

aaacgguucc augag 15aaacgguucc augag 15

＜210＞ 2403<210> 2403

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2403<400> 2403

aacgguucca ugagg 15aacgguucca ugagg 15

＜210＞ 2404<210> 2404

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2404<400> 2404

ugaggaucgu ugggc 15ugaggaucgu ugggc 15

＜210＞ 2405<210> 2405

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2405<400> 2405

ggaucguugg gccua 15ggaucguugg gccua 15

＜210＞ 2406<210> 2406

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2406<400> 2406

ugggccuaaa accug 15ugggccuaaa accug 15

＜210＞ 2407<210> 2407

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2407<400> 2407

ggaacguucc ccauc 15ggaacguucc ccauc 15

＜210＞ 2408<210> 2408

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2408<400> 2408

gaacguuccc cauca 15gaacguuccc cauca 15

＜210＞ 2409<210> 2409

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2409<400> 2409

uccccaucaa cgcgu 15uccccaucaa cgcgu 15

＜210＞ 2410<210> 2410

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2410<400> 2410

aacgcguaca ccaca 15aacgcguaca ccaca 15

＜210＞ 2411<210> 2411

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2411<400> 2411

acacccuccc cggcg 15acacccuccc cggcg 15

＜210＞ 2412<210> 2412

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2412<400> 2412

gaagaguacg uggag 15gaagaguacg uggag 15

＜210＞ 2413<210> 2413

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2413<400> 2413

uggagauuac gcggg 15uggagauuac gcggg 15

＜210＞ 2414<210> 2414

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2414<400> 2414

ggagauuacg cgggu 15ggagauuacg cgggu 15

＜210＞ 2415<210> 2415

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2415<400> 2415

gacggguaug accac 15gacggguaug accac 15

＜210＞ 2416<210> 2416

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2416<400> 2416

gccagguccc ggccc 15gccagguccc ggccc 15

＜210＞ 2417<210> 2417

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2417<400> 2417

gucacauucc agguc 15gucacauucc agguc 15

＜210＞ 2418<210> 2418

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2418<400> 2418

cagugcucac uucca 15cagugcucac uucca 15

＜210＞ 2419<210> 2419

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2419<400> 2419

gcucacuucc augcu 15gcucacuucc augcu 15

＜210＞ 2420<210> 2420

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2420<400> 2420

cucacuucca ugcuc 15cucacuucca ugcuc 15

＜210＞ 2421<210> 2421

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2421<400> 2421

ccaugcucac cgacc 15ccaugcucac cgacc 15

＜210＞ 2422<210> 2422

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2422<400> 2422

gaccccuccc acauu 15gaccccuccc acauu 15

＜210＞ 2423<210> 2423

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2423<400> 2423

cccacauuac agcag 15cccacauuac agcag 15

＜210＞ 2424<210> 2424

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2424<400> 2424

ccacauuaca gcaga 15ccacauuaca gcaga 15

＜210＞ 2425<210> 2425

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2425<400> 2425

gacggcuaaa cguag 15gacggcuaaa cguag 15

＜210＞ 2426<210> 2426

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2426<400> 2426

cagcucuuca gcuag 15cagcucuuca gcuag 15

＜210＞ 2427<210> 2427

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2427<400> 2427

agcucuucag cuagc 15agcucuucag cuagc 15

＜210＞ 2428<210> 2428

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2428<400> 2428

uucagcuagc caauu 15uucagcuagc caauu 15

＜210＞ 2429<210> 2429

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2429<400> 2429

ugcgccuucc uugaa 15ugcgccuucc uugaa 15

＜210＞ 2430<210> 2430

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2430<400> 2430

gcgccuuccu ugaag 15gcgccuuccu ugaag 15

＜210＞ 2431<210> 2431

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2431<400> 2431

ccuuccuuga aggca 15ccuuccuuga aggca 15

＜210＞ 2432<210> 2432

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2432<400> 2432

augcacuacc cacca 15augcacuacc cacca 15

＜210＞ 2433<210> 2433

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2433<400> 2433

caugacuccc cggac 15caugacuccc cggac 15

＜210＞ 2434<210> 2434

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2434<400> 2434

cugaccucau cgagg 15cugaccucau cgagg 15

＜210＞ 2435<210> 2435

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2435<400> 2435

accucaucga ggcca 15accucaucga ggcca 15

＜210＞ 2436<210> 2436

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2436<400> 2436

gaaacaucac ccgug 15gaaacaucac ccgug 15

＜210＞ 2437<210> 2437

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2437<400> 2437

guggagucag agaau 15guggagucag agaau 15

＜210＞ 2438<210> 2438

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2438<400> 2438

agagaauaag guggu 15agagaauaag guggu 15

＜210＞ 2439<210> 2439

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2439<400> 2439

aggugguaau uuugg 15aggugguaau uuugg 15

＜210＞ 2440<210> 2440

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2440<400> 2440

ugguaauuuu ggacu 15ugguaauuuu ggacu 15

＜210＞ 2441<210> 2441

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2441<400> 2441

gguaauuuug gacuc 15gguaauuuug gacuc 15

＜210＞ 2442<210> 2442

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2442<400> 2442

guaauuuugg acucu 15guaauuuugg acucu 15

＜210＞ 2443<210> 2443

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2443<400> 2443

uuggacucuu ucgac 15uuggacucuu ucgac 15

＜210＞ 2444<210> 2444

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2444<400> 2444

ggacucuuuc gaccc 15ggacucuuuc gaccc 15

＜210＞ 2445<210> 2445

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2445<400> 2445

gacucuuucg acccg 15gacucuuucg acccg 15

＜210＞ 2446<210> 2446

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2446<400> 2446

acucuuucga cccgc 15acucuuucga cccgc 15

＜210＞ 2447<210> 2447

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2447<400> 2447

gaaguauccg uugca 15gaaguauccg uugca 15

＜210＞ 2448<210> 2448

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2448<400> 2448

uauccguugc agcag 15uauccguugc agcag 15

＜210＞ 2449<210> 2449

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2449<400> 2449

cagagauccu gcgaa 15cagagauccu gcgaa 15

＜210＞ 2450<210> 2450

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2450<400> 2450

cgaaaaucca agaag 15cgaaaaucca agaag 15

＜210＞ 2451<210> 2451

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2451<400> 2451

aagaaguucc ccccc 15aagaaguucc ccccc 15

＜210＞ 2452<210> 2452

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2452<400> 2452

agaaguuccc ccccg 15agaaguuccc ccccg 15

＜210＞ 2453<210> 2453

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2453<400> 2453

caacccucca cuguu 15caacccucca cuguu 15

＜210＞ 2454<210> 2454

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2454<400> 2454

uuagaguccu ggaaa 15uuagaguccu ggaaa 15

＜210＞ 2455<210> 2455

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2455<400> 2455

gggcccucca auacc 15gggcccucca auacc 15

＜210＞ 2456<210> 2456

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2456<400> 2456

cuccaauacc gccuc 15cuccaauacc gccuc 15

＜210＞ 2457<210> 2457

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2457<400> 2457

accgccucca cggaa 15accgccucca cggaa 15

＜210＞ 2458<210> 2458

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2458<400> 2458

ggacgguugu ucuga 15ggacgguugu ucuga 15

＜210＞ 2459<210> 2459

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2459<400> 2459

cgguuguucu gacag 15cgguuguucu gacag 15

＜210＞ 2460<210> 2460

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2460<400> 2460

gguuguucug acaga 15gguuguucug acaga 15

＜210＞ 2461<210> 2461

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2461<400> 2461

accgugucuu cugcc 15accgugucuu cugcc 15

＜210＞ 2462<210> 2462

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2462<400> 2462

cgugucuucu gccuu 15cgugucuucu gccuu 15

＜210＞ 2463<210> 2463

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2463<400> 2463

gugucuucug ccuug 15gugucuucug ccuug 15

＜210＞ 2464<210> 2464

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2464<400> 2464

ucugccuugg cggag 15ucugccuugg cggag 15

＜210＞ 2465<210> 2465

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2465<400> 2465

ggcagcuccg gaucg 15ggcagcuccg gaucg 15

＜210＞ 2466<210> 2466

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2466<400> 2466

cgccccuccc gauca 15cgccccuccc gauca 15

＜210＞ 2467<210> 2467

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2467<400> 2467

ucccgaucag accuc 15ucccgaucag accuc 15

＜210＞ 2468<210> 2468

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2468<400> 2468

cagaccucug acgac 15cagaccucug acgac 15

＜210＞ 2469<210> 2469

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2469<400> 2469

aaagaaucug acguu 15aaagaaucug acguu 15

＜210＞ 2470<210> 2470

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2470<400> 2470

cugacguuga gucgu 15cugacguuga gucgu 15

＜210＞ 2471<210> 2471

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2471<400> 2471

guugagucgu acucc 15guugagucgu acucc 15

＜210＞ 2472<210> 2472

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2472<400> 2472

gagucguacu ccucc 15gagucguacu ccucc 15

＜210＞ 2473<210> 2473

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2473<400> 2473

auguccuaca caugg 15auguccuaca caugg 15

＜210＞ 2474<210> 2474

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2474<400> 2474

cccugaucac gccau 15cccugaucac gccau 15

＜210＞ 2475<210> 2475

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2475<400> 2475

aacgcguuga gcaac 15aacgcguuga gcaac 15

＜210＞ 2476<210> 2476

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2476<400> 2476

agcaacucuc ugcug 15agcaacucuc ugcug 15

＜210＞ 2477<210> 2477

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2477<400> 2477

caacucucug cugcg 15caacucucug cugcg 15

＜210＞ 2478<210> 2478

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2478<400> 2478

gcugcgucac cacaa 15gcugcgucac cacaa 15

＜210＞ 2479<210> 2479

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2479<400> 2479

acauggucua ugcca 15acauggucua ugcca 15

＜210＞ 2480<210> 2480

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2480<400> 2480

auggucuaug ccaca 15auggucuaug ccaca 15

＜210＞ 2481<210> 2481

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2481<400> 2481

agaaggucac cuuug 15agaaggucac cuuug 15

＜210＞ 2482<210> 2482

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2482<400> 2482

gucaccuuug acaga 15gucaccuuug acaga 15

＜210＞ 2483<210> 2483

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2483<400> 2483

ucaccuuuga cagac 15ucaccuuuga cagac 15

＜210＞ 2484<210> 2484

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2484<400> 2484

acgugcucaa ggaga 15acgugcucaa ggaga 15

＜210＞ 2485<210> 2485

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2485<400> 2485

aaggcgucca caguu 15aaggcgucca caguu 15

＜210＞ 2486<210> 2486

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2486<400> 2486

ccacaguuaa ggcua 15ccacaguuaa ggcua 15

＜210＞ 2487<210> 2487

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2487<400> 2487

cacaguuaag gcuaa 15cacaguuaag gcuaa 15

＜210＞ 2488<210> 2488

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2488<400> 2488

cuaaacuucu auccg 15cuaaacuucu auccg 15

＜210＞ 2489<210> 2489

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2489<400> 2489

uaaacuucua uccgu 15uaaacuucua uccgu 15

＜210＞ 2490<210> 2490

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2490<400> 2490

cccacauucg gccaa 15cccacauucg gccaa 15

＜210＞ 2491<210> 2491

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2491<400> 2491

ccacauucgg ccaaa 15ccacauucgg ccaaa 15

＜210＞ 2492<210> 2492

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2492<400> 2492

aggacguccg gaacc 15aggacguccg gaacc 15

＜210＞ 2493<210> 2493

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2493<400> 2493

ggaaccuauc cagca 15ggaaccuauc cagca 15

＜210＞ 2494<210> 2494

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2494<400> 2494

aaccuaucca gcaag 15aaccuaucca gcaag 15

＜210＞ 2495<210> 2495

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2495<400> 2495

aggccauuaa ccaca 15aggccauuaa ccaca 15

＜210＞ 2496<210> 2496

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2496<400> 2496

ggccauuaac cacau 15ggccauuaac cacau 15

＜210＞ 2497<210> 2497

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2497<400> 2497

caccaauuga cacca 15caccaauuga cacca 15

＜210＞ 2498<210> 2498

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2498<400> 2498

ccaccaucau ggcaa 15ccaccaucau ggcaa 15

＜210＞ 2499<210> 2499

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2499<400> 2499

gugaaguuuu cugcg 15gugaaguuuu cugcg 15

＜210＞ 2500<210> 2500

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2500<400> 2500

ugaaguuuuc ugcgu 15ugaaguuuuc ugcgu 15

＜210＞ 2501<210> 2501

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2501<400> 2501

gaaguuuucu gcguc 15gaaguuuucu gcguc 15

＜210＞ 2502<210> 2502

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2502<400> 2502

aaguuuucug cgucc 15aaguuuucug cgucc 15

＜210＞ 2503<210> 2503

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2503<400> 2503

ucugcgucca accgg 15ucugcgucca accgg 15

＜210＞ 2504<210> 2504

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2504<400> 2504

gccagcucgc cuuau 15gccagcucgc cuuau 15

＜210＞ 2505<210> 2505

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2505<400> 2505

uuaucguauu cccag 15uuaucguauu cccag 15

＜210＞ 2506<210> 2506

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2506<400> 2506

aucguauucc cagac 15aucguauucc cagac 15

＜210＞ 2507<210> 2507

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2507<400> 2507

ucguauuccc agacc 15ucguauuccc agacc 15

＜210＞ 2508<210> 2508

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2508<400> 2508

ugggaguucg uguau 15ugggaguucg uguau 15

＜210＞ 2509<210> 2509

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2509<400> 2509

gggaguucgu guaug 15gggaguucgu guaug 15

＜210＞ 2510<210> 2510

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2510<400> 2510

uucguguaug cgaga 15uucguguaug cgaga 15

＜210＞ 2511<210> 2511

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2511<400> 2511

aauggcucuu uacga 15aauggcucuu uacga 15

＜210＞ 2512<210> 2512

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2512<400> 2512

uggcucuuua cgacg 15uggcucuuua cgacg 15

＜210＞ 2513<210> 2513

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2513<400> 2513

ggcucuuuac gacgu 15ggcucuuuac gacgu 15

＜210＞ 2514<210> 2514

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2514<400> 2514

gcucuuuacg acgug 15gcucuuuacg acgug 15

＜210＞ 2515<210> 2515

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2515<400> 2515

acguggucuc caccc 15acguggucuc caccc 15

＜210＞ 2516<210> 2516

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2516<400> 2516

guggucucca cccuu 15guggucucca cccuu 15

＜210＞ 2517<210> 2517

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2517<400> 2517

ccacccuucc ucagg 15ccacccuucc ucagg 15

＜210＞ 2518<210> 2518

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2518<400> 2518

cacccuuccu caggc 15cacccuuccu caggc 15

＜210＞ 2519<210> 2519

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2519<400> 2519

ccuuccucag gccgu 15ccuuccucag gccgu 15

＜210＞ 2520<210> 2520

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2520<400> 2520

augggcuccu cguac 15augggcuccu cguac 15

＜210＞ 2521<210> 2521

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2521<400> 2521

ggcuccucgu acgga 15ggcuccucgu acgga 15

＜210＞ 2522<210> 2522

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2522<400> 2522

acggauucca guacu 15acggauucca guacu 15

＜210＞ 2523<210> 2523

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2523<400> 2523

caguacucuc cuggg 15caguacucuc cuggg 15

＜210＞ 2524<210> 2524

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2524<400> 2524

aagcccuaug ggcuu 15aagcccuaug ggcuu 15

＜210＞ 2525<210> 2525

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2525<400> 2525

augggcuucu cguau 15augggcuucu cguau 15

＜210＞ 2526<210> 2526

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2526<400> 2526

ugggcuucuc guaug 15ugggcuucuc guaug 15

＜210＞ 2527<210> 2527

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2527<400> 2527

ggcuucucgu augac 15ggcuucucgu augac 15

＜210＞ 2528<210> 2528

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2528<400> 2528

uucucguaug acacc 15uucucguaug acacc 15

＜210＞ 2529<210> 2529

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2529<400> 2529

cgcugcuuug acuca 15cgcugcuuug acuca 15

＜210＞ 2530<210> 2530

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2530<400> 2530

gcugcuuuga cucaa 15gcugcuuuga cucaa 15

＜210＞ 2531<210> 2531

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2531<400> 2531

uuugacucaa caguc 15uuugacucaa caguc 15

＜210＞ 2532<210> 2532

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2532<400> 2532

caacagucac ugaga 15caacagucac ugaga 15

＜210＞ 2533<210> 2533

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2533<400> 2533

gcgacauccg uguug 15gcgacauccg uguug 15

＜210＞ 2534<210> 2534

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2534<400> 2534

uccguguuga ggagu 15uccguguuga ggagu 15

＜210＞ 2535<210> 2535

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2535<400> 2535

gaggagucaa ucuac 15gaggagucaa ucuac 15

＜210＞ 2536<210> 2536

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2536<400> 2536

agucaaucua ccaau 15agucaaucua ccaau 15

＜210＞ 2537<210> 2537

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2537<400> 2537

ucaaucuacc aaugu 15ucaaucuacc aaugu 15

＜210＞ 2538<210> 2538

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2538<400> 2538

ccaauguugu gacuu 15ccaauguugu gacuu 15

＜210＞ 2539<210> 2539

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2539<400> 2539

ugugacuugg ccccc 15ugugacuugg ccccc 15

＜210＞ 2540<210> 2540

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2540<400> 2540

ccugacuaau ucaaa 15ccugacuaau ucaaa 15

＜210＞ 2541<210> 2541

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2541<400> 2541

gacuaauuca aaagg 15gacuaauuca aaagg 15

＜210＞ 2542<210> 2542

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2542<400> 2542

acuaauucaa aaggg 15acuaauucaa aaggg 15

＜210＞ 2543<210> 2543

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2543<400> 2543

cggcaauacc cucac 15cggcaauacc cucac 15

＜210＞ 2544<210> 2544

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2544<400> 2544

auacccucac augcu 15auacccucac augcu 15

＜210＞ 2545<210> 2545

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2545<400> 2545

acaugcuacu ugaaa 15acaugcuacu ugaaa 15

＜210＞ 2546<210> 2546

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2546<400> 2546

ugcuacuuga aagcc 15ugcuacuuga aagcc 15

＜210＞ 2547<210> 2547

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2547<400> 2547

ugucguuauc uguga 15ugucguuauc uguga 15

＜210＞ 2548<210> 2548

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2548<400> 2548

ucguuaucug ugaaa 15ucguuaucug ugaaa 15

＜210＞ 2549<210> 2549

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2549<400> 2549

cgagccuacg agucu 15cgagccuacg agucu 15

＜210＞ 2550<210> 2550

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2550<400> 2550

uacgagucuu cacgg 15uacgagucuu cacgg 15

＜210＞ 2551<210> 2551

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2551<400> 2551

cgagucuuca cggag 15cgagucuuca cggag 15

＜210＞ 2552<210> 2552

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2552<400> 2552

gagucuucac ggagg 15gagucuucac ggagg 15

＜210＞ 2553<210> 2553

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2553<400> 2553

ggaggcuaug acuag 15ggaggcuaug acuag 15

＜210＞ 2554<210> 2554

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2554<400> 2554

uaugacuagg uacuc 15uaugacuagg uacuc 15

＜210＞ 2555<210> 2555

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2555<400> 2555

acuagguacu cugcc 15acuagguacu cugcc 15

＜210＞ 2556<210> 2556

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2556<400> 2556

uacgacuugg aguug 15uacgacuugg aguug 15

＜210＞ 2557<210> 2557

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2557<400> 2557

uuggaguuga uaaca 15uuggaguuga uaaca 15

＜210＞ 2558<210> 2558

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2558<400> 2558

aguugauaac aucau 15aguugauaac aucau 15

＜210＞ 2559<210> 2559

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2559<400> 2559

auaacaucau gcucc 15auaacaucau gcucc 15

＜210＞ 2560<210> 2560

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2560<400> 2560

aacgugucgg ucgcg 15aacgugucgg ucgcg 15

＜210＞ 2561<210> 2561

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2561<400> 2561

ugucggucgc gcacg 15ugucggucgc gcacg 15

＜210＞ 2562<210> 2562

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2562<400> 2562

agaguguacu accuc 15agaguguacu accuc 15

＜210＞ 2563<210> 2563

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2563<400> 2563

guguacuacc ucacu 15guguacuacc ucacu 15

＜210＞ 2564<210> 2564

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2564<400> 2564

acuaccucac ucgug 15acuaccucac ucgug 15

＜210＞ 2565<210> 2565

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2565<400> 2565

ccucacucgu gaucc 15ccucacucgu gaucc 15

＜210＞ 2566<210> 2566

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2566<400> 2566

ucgugauccc accac 15ucgugauccc accac 15

＜210＞ 2567<210> 2567

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2567<400> 2567

gacagcuaga cacac 15gacagcuaga cacac 15

＜210＞ 2568<210> 2568

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2568<400> 2568

acacacucca gucaa 15acacacucca gucaa 15

＜210＞ 2569<210> 2569

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2569<400> 2569

cuccagucaa cuccu 15cuccagucaa cuccu 15

＜210＞ 2570<210> 2570

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2570<400> 2570

gucaacuccu ggcua 15gucaacuccu ggcua 15

＜210＞ 2571<210> 2571

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2571<400> 2571

ccuggcuagg caaca 15ccuggcuagg caaca 15

＜210＞ 2572<210> 2572

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2572<400> 2572

gcaacaucau caugu 15gcaacaucau caugu 15

＜210＞ 2573<210> 2573

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2573<400> 2573

acaucaucau guaug 15acaucaucau guaug 15

＜210＞ 2574<210> 2574

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2574<400> 2574

ggaugauuuu gauga 15ggaugauuuu gauga 15

＜210＞ 2575<210> 2575

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2575<400> 2575

augauuuuga ugacu 15augauuuuga ugacu 15

＜210＞ 2576<210> 2576

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2576<400> 2576

acucacuucu ucucc 15acucacuucu ucucc 15

＜210＞ 2577<210> 2577

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2577<400> 2577

cucacuucuu cucca 15cucacuucuu cucca 15

＜210＞ 2578<210> 2578

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2578<400> 2578

cacuucuucu ccauc 15cacuucuucu ccauc 15

＜210＞ 2579<210> 2579

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2579<400> 2579

acuucuucuc caucc 15acuucuucuc caucc 15

＜210＞ 2580<210> 2580

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2580<400> 2580

uucuucucca uccuu 15uucuucucca uccuu 15

＜210＞ 2581<210> 2581

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2581<400> 2581

ucuccauccu ucuag 15ucuccauccu ucuag 15

＜210＞ 2582<210> 2582

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2582<400> 2582

ccauccuucu agccc 15ccauccuucu agccc 15

＜210＞ 2583<210> 2583

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2583<400> 2583

cauccuucua gccca 15cauccuucua gccca 15

＜210＞ 2584<210> 2584

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2584<400> 2584

uccuucuagc ccagg 15uccuucuagc ccagg 15

＜210＞ 2585<210> 2585

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2585<400> 2585

aacagcuuga aaagg 15aacagcuuga aaagg 15

＜210＞ 2586<210> 2586

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2586<400> 2586

ggccuguuac uccau 15ggccuguuac uccau 15

＜210＞ 2587<210> 2587

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2587<400> 2587

gccuguuacu ccauu 15gccuguuacu ccauu 15

＜210＞ 2588<210> 2588

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2588<400> 2588

uguuacucca uugag 15uguuacucca uugag 15

＜210＞ 2589<210> 2589

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2589<400> 2589

acuccauuga gccac 15acuccauuga gccac 15

＜210＞ 2590<210> 2590

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2590<400> 2590

agccacuuga ccuac 15agccacuuga ccuac 15

＜210＞ 2591<210> 2591

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2591<400> 2591

uugaccuacc ucaga 15uugaccuacc ucaga 15

＜210＞ 2592<210> 2592

＜211＞ 15＜212＞ RNA<211> 15 <212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2592<400> 2592

ccuaccucag aucau 15ccuaccucag aucau 15

＜210＞ 2593<210> 2593

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2593<400> 2593

cucagaucau ucaac 15cucagaucau ucaac 15

＜210＞ 2594<210> 2594

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2594<400> 2594

agaucauuca acgac 15agaucauuca acgac 15

＜210＞ 2595<210> 2595

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2595<400> 2595

gaucauucaa cgacu 15gaucauucaa cgacu 15

＜210＞ 2596<210> 2596

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2596<400> 2596

aacgacucca ugguc 15aacgacucca ugguc 15

＜210＞ 2597<210> 2597

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2597<400> 2597

ccauggucuu agcgc 15ccauggucuu agcgc 15

＜210＞ 2598<210> 2598

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2598<400> 2598

auggucuuag cgcau 15auggucuuag cgcau 15

＜210＞ 2599<210> 2599

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2599<400> 2599

uggucuuagc gcauu 15uggucuuagc gcauu 15

＜210＞ 2600<210> 2600

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2600<400> 2600

agcgcauucu cacuc 15agcgcauucu cacuc 15

＜210＞ 2601<210> 2601

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2601<400> 2601

gcgcauucuc acucc 15gcgcauucuc acucc 15

＜210＞ 2602<210> 2602

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2602<400> 2602

gcauucucac uccau 15gcauucucac uccau 15

＜210＞ 2603<210> 2603

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2603<400> 2603

ucucacucca uaguu 15ucucacucca uaguu 15

＜210＞ 2604<210> 2604

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2604<400> 2604

acuccauagu uacuc 15acuccauagu uacuc 15

＜210＞ 2605<210> 2605

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2605<400> 2605

ccauaguuac ucucc 15ccauaguuac ucucc 15

＜210＞ 2606<210> 2606

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2606<400> 2606

cauaguuacu cucca 15cauaguuacu cucca 15

＜210＞ 2607<210> 2607

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2607<400> 2607

aguuacucuc caggu 15aguuacucuc caggu 15

＜210＞ 2608<210> 2608

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2608<400> 2608

uuacucucca gguga 15uuacucucca gguga 15

＜210＞ 2609<210> 2609

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2609<400> 2609

gugagaucaa uaggg 15gugagaucaa uaggg 15

＜210＞ 2610<210> 2610

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2610<400> 2610

gaucaauagg guggc 15gaucaauagg guggc 15

＜210＞ 2611<210> 2611

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2611<400> 2611

gguggcuuca ugccu 15gguggcuuca ugccu 15

＜210＞ 2612<210> 2612

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2612<400> 2612

guggcuucau gccuc 15guggcuucau gccuc 15

＜210＞ 2613<210> 2613

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2613<400> 2613

gagacaucgg gccag 15gagacaucgg gccag 15

＜210＞ 2614<210> 2614

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2614<400> 2614

ggcaaguacc ucuuc 15ggcaaguacc ucuuc 15

＜210＞ 2615<210> 2615

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2615<400> 2615

aguaccucuu caacu 15aguaccucuu caacu 15

＜210＞ 2616<210> 2616

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2616<400> 2616

uaccucuuca acugg 15uaccucuuca acugg 15

＜210＞ 2617<210> 2617

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2617<400> 2617

accucuucaa cuggg 15accucuucaa cuggg 15

＜210＞ 2618<210> 2618

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2618<400> 2618

gggcaguaag gacca 15gggcaguaag gacca 15

＜210＞ 2619<210> 2619

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2619<400> 2619

ccaagcucaa acuca 15ccaagcucaa acuca 15

＜210＞ 2620<210> 2620

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2620<400> 2620

ucaaacucac uccaa 15ucaaacucac uccaa 15

＜210＞ 2621<210> 2621

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2621<400> 2621

acucacucca auccc 15acucacucca auccc 15

＜210＞ 2622<210> 2622

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2622<400> 2622

cuccaauccc ggccg 15cuccaauccc ggccg 15

＜210＞ 2623<210> 2623

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2623<400> 2623

ugcugguuac agcgg 15ugcugguuac agcgg 15

＜210＞ 2624<210> 2624

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2624<400> 2624

gcugguuaca gcggg 15gcugguuaca gcggg 15

＜210＞ 2625<210> 2625

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2625<400> 2625

ccugucucgu gcccg 15ccugucucgu gcccg 15

＜210＞ 2626<210> 2626

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2626<400> 2626

cgcugguuua ugugg 15cgcugguuua ugugg 15

＜210＞ 2627<210> 2627

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2627<400> 2627

gcugguuuau guggu 15gcugguuuau guggu 15

＜210＞ 2628<210> 2628

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2628<400> 2628

cugguuuaug uggug 15cugguuuaug uggug 15

＜210＞ 2629<210> 2629

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2629<400> 2629

aggccauccc cuuuu 15aggccauccc cuuuu 15

＜210＞ 2630<210> 2630

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2630<400> 2630

auccccuuuu uuuuu 15auccccuuuu uuuuu 15

＜210＞ 2631<210> 2631

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2631<400> 2631

cccccaagaa ggggaccaga gaaacangua cauuaccugg ua 42cccccaagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2632<210> 2632

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2632<400> 2632

cgugaaagaa guagaccaga gaaacangua cauuaccugg ua 42cgugaaagaa guagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2633<210> 2633

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2633<400> 2633

ccuggaagaa gcacaccaga gaaacangua cauuaccugg ua 42ccuggaagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2634<210> 2634

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2634<400> 2634

gcauugagaa gguuaccaga gaaacangua cauuaccugg ua 42gcauugagaa gguuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2635<210> 2635

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2635<400> 2635

cuaucaagaa guacaccaga gaaacangua cauuaccugg ua 42cuaucaagaa guacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2636<210> 2636

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2636<400> 2636

gugggcagaa guagaccaga gaaacangua cauuaccugg ua 42gugggcagaa guagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2637<210> 2637

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2637<400> 2637

ccugugagaa gcggaccaga gaaacangua cauuaccugg ua 42ccugugagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2638<210> 2638

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2638<400> 2638

ccaacgagaa gaccaccaga gaaacangua cauuaccugg ua 42ccaacgagaa gaccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2639<210> 2639

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2639<400> 2639

gguugcagaa guucaccaga gaaacangua cauuaccugg ua 42gguugcagaa guucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2640<210> 2640

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2640<400> 2640

ccucggagaa gcgaaccaga gaaacangua cauuaccugg ua 42ccucggagaa gcgaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2641<210> 2641

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2641<400> 2641

uacccaagaa gagcaccaga gaaacangua cauuaccugg ua 42uacccaagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2642<210> 2642

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2642<400> 2642

gccgggagaa gcggaccaga gaaacangua cauuaccugg ua 42gccgggagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2643<210> 2643

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2643<400> 2643

caacuaagaa gggaaccaga gaaacangua cauuaccugg ua 42caacuaagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2644<210> 2644

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2644<400> 2644

ccggggagaa guggaccaga gaaacangua cauuaccugg ua 42ccggggagaa guggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2645<210> 2645

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2645<400> 2645

cggcgaagaa gcacaccaga gaaacangua cauuaccugg ua 42cggcgaagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2646<210> 2646

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2646<400> 2646

caugagagaa gcgaaccaga gaaacangua cauuaccugg ua 42caugagagaa gcgaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2647<210> 2647

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2647<400> 2647

ccgacgagaa gaauaccaga gaaacangua cauuaccugg ua 42ccgacgagaa gaauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2648<210> 2648

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2648<400> 2648

aagagcagaa gggcaccaga gaaacangua cauuaccugg ua 42aagagcagaa gggcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2649<210> 2649

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2649<400> 2649

caggacagaa gggcaccaga gaaacangua cauuaccugg ua 42caggacagaa gggcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2650<210> 2650

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2650<400> 2650

aaacagagaa gcagaccaga gaaacangua cauuaccugg ua 42aaacagagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2651<210> 2651

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2651<400> 2651

uggucaagaa ggacaccaga gaaacangua cauuaccugg ua 42uggucaagaa ggacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2652<210> 2652

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2652<400> 2652

agcggaagaa gggaaccaga gaaacangua cauuaccugg ua 42agcggaagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2653<210> 2653

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2653<400> 2653

cugauaagaa gaagaccaga gaaacangua cauuaccugg ua 42cugauaagaa gaagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2654<210> 2654

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2654<400> 2654

aguuggagaa gucaaccaga gaaacangua cauuaccugg ua 42aguuggagaa gucaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2655<210> 2655

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2655<400> 2655

cccaacagaa ggagaccaga gaaacangua cauuaccugg ua 42cccaacagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2656<210> 2656

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2656<400> 2656

gaaagcagaa gcccaccaga gaaacangua cauuaccugg ua 42gaaagcagaa gcccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2657<210> 2657

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2657<400> 2657

acagaaagaa gccgaccaga gaaacangua cauuaccugg ua 42acagaaagaa gccgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2658<210> 2658

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2658<400> 2658

uggcggagaa gaaaaccaga gaaacangua cauuaccugg ua 42uggcggagaa gaaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2659<210> 2659

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2659<400> 2659

aaacggagaa gcagaccaga gaaacangua cauuaccugg ua 42aaacggagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2660<210> 2660

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2660<400> 2660

gaggaaagaa gaucaccaga gaaacangua cauuaccugg ua 42gaggaaagaa gaucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2661<210> 2661

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2661<400> 2661

gugaacagaa gggaaccaga gaaacangua cauuaccugg ua 42gugaacagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2662<210> 2662

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2662<400> 2662

cacuagagaa guugaccaga gaaacangua cauuaccugg ua 42cacuagagaa guugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2663<210> 2663

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2663<400> 2663

ugugggagaa ggagaccaga gaaacangua cauuaccugg ua 42ugugggagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2664<210> 2664

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2664<400> 2664

auccacagaa gcuuaccaga gaaacangua cauuaccugg ua 42auccacagaa gcuuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2665<210> 2665

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2665<400> 2665

ucucugagaa ggccaccaga gaaacangua cauuaccugg ua 42ucucugagaa ggccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2666<210> 2666

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2666<400> 2666

uuuaugagaa ggauaccaga gaaacangua cauuaccugg ua 42uuuaugagaa ggauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2667<210> 2667

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2667<400> 2667

ugugccagaa gccaaccaga gaaacangua cauuaccugg ua 42ugugccagaa gccaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2668<210> 2668

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2668<400> 2668

guucagagaa guccaccaga gaaacangua cauuaccugg ua 42guucagagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2669<210> 2669

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2669<400> 2669

gcguagagaa gugcaccaga gaaacangua cauuaccugg ua 42gcguagagaa gugcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2670<210> 2670

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2670<400> 2670

cugggcagaa ggacaccaga gaaacangua cauuaccugg ua 42cugggcagaa ggacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2671<210> 2671

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2671<400> 2671

agcugcagaa ggccaccaga gaaacangua cauuaccugg ua 42agcugcagaa ggccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2672<210> 2672

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2672<400> 2672

cgauggagaa gcagaccaga gaaacangua cauuaccugg ua 42cgauggagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2673<210> 2673

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2673<400> 2673

aaugccagaa guaaaccaga gaaacangua cauuaccugg ua 42aaugccagaa guaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2674<210> 2674

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2674<400> 2674

gggugaagaa guacaccaga gaaacangua cauuaccugg ua 42gggugaagaa guacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2675<210> 2675

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2675<400> 2675

cacuacagaa gggcaccaga gaaacangua cauuaccugg ua 42cacuacagaa gggcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2676<210> 2676

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2676<400> 2676

ggaccgagaa gucgaccaga gaaacangua cauuaccugg ua 42ggaccgagaa gucgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2677<210> 2677

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2677<400> 2677

gcaccgagaa gaucaccaga gaaacangua cauuaccugg ua 42gcaccgagaa gaucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2678<210> 2678

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2678<400> 2678

cagcacagaa gucuaccaga gaaacangua cauuaccugg ua 42cagcacagaa gucuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2679<210> 2679

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2679<400> 2679

uugagaagaa gcacaccaga gaaacangua cauuaccugg ua 42uugagaagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2680<210> 2680

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2680<400> 2680

uguggcagaa gcguaccaga gaaacangua cauuaccugg ua 42uguggcagaa gcguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2681<210> 2681

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2681<400> 2681

ccguggagaa ggucaccaga gaaacangua cauuaccugg ua 42ccguggagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2682<210> 2682

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2682<400> 2682

aaagcaagaa guggaccaga gaaacangua cauuaccugg ua 42aaagcaagaa guggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2683<210> 2683

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2683<400> 2683

gcuccgagaa guccaccaga gaaacangua cauuaccugg ua 42gcuccgagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2684<210> 2684

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2684<400> 2684

gcagcgagaa gagcaccaga gaaacangua cauuaccugg ua 42gcagcgagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2685<210> 2685

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2685<400> 2685

agcagcagaa ggcuaccaga gaaacangua cauuaccugg ua 42agcagcagaa ggcuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2686<210> 2686

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2686<400> 2686

gacagcagaa gcggaccaga gaaacangua cauuaccugg ua 42gacagcagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2687<210> 2687

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2687<400> 2687

guggacagaa gcagaccaga gaaacangua cauuaccugg ua 42guggacagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2688<210> 2688

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2688<400> 2688

gucgugagaa gcagaccaga gaaacangua cauuaccugg ua 42gucgugagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2689<210> 2689

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2689<400> 2689

ugaaggagaa gggaaccaga gaaacangua cauuaccugg ua 42ugaaggagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2690<210> 2690

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2690<400> 2690

ggacagagaa gguaaccaga gaaacangua cauuaccugg ua 42ggacagagaa gguaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2691<210> 2691

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2691<400> 2691

ccagugagaa gagcaccaga gaaacangua cauuaccugg ua 42ccagugagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2692<210> 2692

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2692<400> 2692

ggagacagaa gcugaccaga gaaacangua cauuaccugg ua 42ggagacagaa gcugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2693<210> 2693

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2693<400> 2693

gcgcgcagaa gccaaccaga gaaacangua cauuaccugg ua 42gcgcgcagaa gccaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2694<210> 2694

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2694<400> 2694

uccacaagaa ggcaaccaga gaaacangua cauuaccugg ua 42uccacaagaa ggcaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2695<210> 2695

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2695<400> 2695

gcuaucagaa gcauaccaga gaaacangua cauuaccugg ua 42gcuaucagaa gcauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2696<210> 2696

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2696<400> 2696

cucuagagaa gccuaccaga gaaacangua cauuaccugg ua 42cucuagagaa gccuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2697<210> 2697

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2697<400> 2697

aaugccagaa gcucaccaga gaaacangua cauuaccugg ua 42aaugccagaa gcucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2698<210> 2698

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2698<400> 2698

guaccaagaa gcacaccaga gaaacangua cauuaccugg ua 42guaccaagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2699<210> 2699

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2699<400> 2699

aggagcagaa gccaaccaga gaaacangua cauuaccugg ua 42aggagcagaa gccaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2700<210> 2700

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2700<400> 2700

agcaggagaa gcggaccaga gaaacangua cauuaccugg ua 42agcaggagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2701<210> 2701

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2701<400> 2701

agcaggagaa ggagaccaga gaaacangua cauuaccugg ua 42agcaggagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2702<210> 2702

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2702<400> 2702

aacgccagaa ggagaccaga gaaacangua cauuaccugg ua 42aacgccagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2703<210> 2703

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2703<400> 2703

ugggugagaa gcacaccaga gaaacangua cauuaccugg ua 42ugggugagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2704<210> 2704

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2704<400> 2704

auggcgagaa ggagaccaga gaaacangua cauuaccugg ua 42auggcgagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2705<210> 2705

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2705<400> 2705

ugagcgagaa gagaaccaga gaaacangua cauuaccugg ua 42ugagcgagaa gagaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2706<210> 2706

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2706<400> 2706

accaugagaa gaccaccaga gaaacangua cauuaccugg ua 42accaugagaa gaccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2707<210> 2707

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2707<400> 2707

gaagacagaa ggcuaccaga gaaacangua cauuaccugg ua 42gaagacagaa ggcuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2708<210> 2708

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2708<400> 2708

gagacgagaa guccaccaga gaaacangua cauuaccugg ua 42gagacgagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2709<210> 2709

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2709<400> 2709

ggcggaagaa ggcaaccaga gaaacangua cauuaccugg ua 42ggcggaagaa ggcaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2710<210> 2710

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2710<400> 2710

ccuucgagaa gagaaccaga gaaacangua cauuaccugg ua 42ccuucgagaa gagaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2711<210> 2711

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2711<400> 2711

gcuaucagaa ggucaccaga gaaacangua cauuaccugg ua 42gcuaucagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2712<210> 2712

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2712<400> 2712

ggcguaagaa gugaaccaga gaaacangua cauuaccugg ua 42ggcguaagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2713<210> 2713

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2713<400> 2713

guggaaagaa guccaccaga gaaacangua cauuaccugg ua 42guggaaagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2714<210> 2714

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2714<400> 2714

ucuuugagaa ggcgaccaga gaaacangua cauuaccugg ua 42ucuuugagaa ggcgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2715<210> 2715

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2715<400> 2715

cuuuugagaa ggcuaccaga gaaacangua cauuaccugg ua 42cuuuugagaa ggcuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2716<210> 2716

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2716<400> 2716

caugccagaa gacgaccaga gaaacangua cauuaccugg ua 42caugccagaa gacgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2717<210> 2717

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2717<400> 2717

auagagagaa gagcaccaga gaaacangua cauuaccugg ua 42auagagagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2718<210> 2718

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2718<400> 2718

aaugacagaa gcauaccaga gaaacangua cauuaccugg ua 42aaugacagaa gcauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2719<210> 2719

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2719<400> 2719

caccgcagaa gcgcaccaga gaaacangua cauuaccugg ua 42caccgcagaa gcgcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2720<210> 2720

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2720<400> 2720

ucccccagaa gucaaccaga gaaacangua cauuaccugg ua 42ucccccagaa gucaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2721<210> 2721

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2721<400> 2721

cuggggagaa guagaccaga gaaacangua cauuaccugg ua 42cuggggagaa guagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2722<210> 2722

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2722<400> 2722

agacggagaa ggggaccaga gaaacangua cauuaccugg ua 42agacggagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2723<210> 2723

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2723<400> 2723

auaggaagaa ggucaccaga gaaacangua cauuaccugg ua 42auaggaagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2724<210> 2724

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2724<400> 2724

gggcagagaa guggaccaga gaaacangua cauuaccugg ua 42gggcagagaa guggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2725<210> 2725

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2725<400> 2725

ccgaagagaa gagcaccaga gaaacangua cauuaccugg ua 42ccgaagagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2726<210> 2726

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2726<400> 2726

gcacacagaa gcccaccaga gaaacangua cauuaccugg ua 42gcacacagaa gcccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2727<210> 2727

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2727<400> 2727

agacucagaa gguaaccaga gaaacangua cauuaccugg ua 42agacucagaa gguaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2728<210> 2728

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2728<400> 2728

accgggagaa gcauaccaga gaaacangua cauuaccugg ua 42accgggagaa gcauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2729<210> 2729

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2729<400> 2729

cgugaaagaa ggggaccaga gaaacangua cauuaccugg ua 42cgugaaagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2730<210> 2730

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2730<400> 2730

cgguacagaa ggggaccaga gaaacangua cauuaccugg ua 42cgguacagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2731<210> 2731

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2731<400> 2731

guacgcagaa ggcaaccaga gaaacangua cauuaccugg ua 42guacgcagaa ggcaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2732<210> 2732

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2732<400> 2732

cccuugagaa gcguaccaga gaaacangua cauuaccugg ua 42cccuugagaa gcguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2733<210> 2733

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2733<400> 2733

ggcggcagaa gaugaccaga gaaacangua cauuaccugg ua 42ggcggcagaa gaugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2734<210> 2734

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2734<400> 2734

guugggagaa guacaccaga gaaacangua cauuaccugg ua 42guugggagaa guacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2735<210> 2735

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2735<400> 2735

uccaccagaa gcaaaccaga gaaacangua cauuaccugg ua 42uccaccagaa gcaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2736<210> 2736

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2736<400> 2736

agucgaagaa guugaccaga gaaacangua cauuaccugg ua 42agucgaagaa guugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2737<210> 2737

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2737<400> 2737

guccagagaa gugcaccaga gaaacangua cauuaccugg ua 42guccagagaa gugcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2738<210> 2738

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2738<400> 2738

cgcuccagaa gucuaccaga gaaacangua cauuaccugg ua 42cgcuccagaa gucuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2739<210> 2739

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2739<400> 2739

acgacgagaa gcgcaccaga gaaacangua cauuaccugg ua 42acgacgagaa gcgcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2740<210> 2740

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2740<400> 2740

guguugagaa gagcaccaga gaaacangua cauuaccugg ua 42guguugagaa gagcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2741<210> 2741

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2741<400> 2741

ccgcuaagaa guauaccaga gaaacangua cauuaccugg ua 42ccgcuaagaa guauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2742<210> 2742

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2742<400> 2742

uagagcagaa guugaccaga gaaacangua cauuaccugg ua 42uagagcagaa guugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2743<210> 2743

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2743<400> 2743

gaaaucagaa gucuaccaga gaaacangua cauuaccugg ua 42gaaaucagaa gucuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2744<210> 2744

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2744<400> 2744

gauccaagaa gaaaaccaga gaaacangua cauuaccugg ua 42gauccaagaa gaaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2745<210> 2745

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2745<400> 2745

cccgagagaa guucaccaga gaaacangua cauuaccugg ua 42cccgagagaa guucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2746<210> 2746

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2746<400> 2746

acacagagaa gaagaccaga gaaacangua cauuaccugg ua 42acacagagaa gaagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2747<210> 2747

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2747<400> 2747

agucucagaa ggcgaccaga gaaacangua cauuaccugg ua 42agucucagaa ggcgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2748<210> 2748

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2748<400> 2748

cuggcaagaa ggcaaccaga gaaacangua cauuaccugg ua 42cuggcaagaa ggcaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2749<210> 2749

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2749<400> 2749

guuuggagaa ggaaaccaga gaaacangua cauuaccugg ua 42guuuggagaa ggaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2750<210> 2750

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2750<400> 2750

gguuuaagaa guauaccaga gaaacangua cauuaccugg ua 42gguuuaagaa guauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2751<210> 2751

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2751<400> 2751

cuauacagaa ggggaccaga gaaacangua cauuaccugg ua 42cuauacagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2752<210> 2752

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2752<400> 2752

auuuugagaa gcucaccaga gaaacangua cauuaccugg ua 42auuuugagaa gcucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2753<210> 2753

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2753<400> 2753

caggucagaa gacaaccaga gaaacangua cauuaccugg ua 42caggucagaa gacaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2754<210> 2754

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2754<400> 2754

cuccagagaa gccgaccaga gaaacangua cauuaccugg ua 42cuccagagaa gccgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2755<210> 2755

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2755<400> 2755

ggccagagaa gcaaaccaga gaaacangua cauuaccugg ua 42ggccagagaa gcaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2756<210> 2756

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2756<400> 2756

aacaacagaa ggccaccaga gaaacangua cauuaccugg ua 42aacaacagaa ggccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2757<210> 2757

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2757<400> 2757

gggaacagaa gccgaccaga gaaacangua cauuaccugg ua 42gggaacagaa gccgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2758<210> 2758

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2758<400> 2758

ucggcgagaa gcauaccaga gaaacangua cauuaccugg ua 42ucggcgagaa gcauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2759<210> 2759

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2759<400> 2759

ugcuugagaa gcucaccaga gaaacangua cauuaccugg ua 42ugcuugagaa gcucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2760<210> 2760

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2760<400> 2760

gggagcagaa gccuaccaga gaaacangua cauuaccugg ua 42gggagcagaa gccuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2761<210> 2761

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2761<400> 2761

cacgggagaa gcggaccaga gaaacangua cauuaccugg ua 42cacgggagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2762<210> 2762

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2762<400> 2762

uucccaagaa gaguaccaga gaaacangua cauuaccugg ua 42uucccaagaa gaguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2763<210> 2763

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2763<400> 2763

aaugccagaa gugaaccaga gaaacangua cauuaccugg ua 42aaugccagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2764<210> 2764

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2764<400> 2764

gauagaagaa gugaaccaga gaaacangua cauuaccugg ua 42gauagaagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2765<210> 2765

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2765<400> 2765

ugagcgagaa ggugaccaga gaaacangua cauuaccugg ua 42ugagcgagaa ggugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2766<210> 2766

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2766<400> 2766

guggugagaa gacuaccaga gaaacangua cauuaccugg ua 42guggugagaa gacuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2767<210> 2767

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2767<400> 2767

auguugagaa ggagaccaga gaaacangua cauuaccugg ua 42auguugagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2768<210> 2768

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2768<400> 2768

gaguugagaa gccaaccaga gaaacangua cauuaccugg ua 42gaguugagaa gccaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2769<210> 2769

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2769<400> 2769

ggccgaagaa gcacaccaga gaaacangua cauuaccugg ua 42ggccgaagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2770<210> 2770

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2770<400> 2770

cacgaaagaa gaagaccaga gaaacangua cauuaccugg ua 42cacgaaagaa gaagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2771<210> 2771

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2771<400> 2771

guccucagaa gaggaccaga gaaacangua cauuaccugg ua 42guccucagaa gaggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2772<210> 2772

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2772<400> 2772

gcuaucagaa gguuaccaga gaaacangua cauuaccugg ua 42gcuaucagaa gguuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2773<210> 2773

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2773<400> 2773

gagaggagaa gaguaccaga gaaacangua cauuaccugg ua 42gagaggagaa gaguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2774<210> 2774

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2774<400> 2774

uggugaagaa ggagaccaga gaaacangua cauuaccugg ua 42uggugaagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2775<210> 2775

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2775<400> 2775

uucagcagaa gaguaccaga gaaacangua cauuaccugg ua 42uucagcagaa gaguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2776<210> 2776

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2776<400> 2776

cucuucagaa gcugaccaga gaaacangua cauuaccugg ua 42cucuucagaa gcugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2777<210> 2777

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2777<400> 2777

gcguggagaa guccaccaga gaaacangua cauuaccugg ua 42gcguggagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2778<210> 2778

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2778<400> 2778

gccacgagaa ggagaccaga gaaacangua cauuaccugg ua 42gccacgagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2779<210> 2779

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2779<400> 2779

cuugaaagaa gucaaccaga gaaacangua cauuaccugg ua 42cuugaaagaa gucaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2780<210> 2780

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2780<400> 2780

agcuugagaa ggagaccaga gaaacangua cauuaccugg ua 42agcuugagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2781<210> 2781

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2781<400> 2781

aauuucagaa ggagaccaga gaaacangua cauuaccugg ua 42aauuucagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2782<210> 2782

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2782<400> 2782

cacaugagaa ggugaccaga gaaacangua cauuaccugg ua 42cacaugagaa ggugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2783<210> 2783

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2783<400> 2783

ucauggagaa guuuaccaga gaaacangua cauuaccugg ua 42ucauggagaa guuuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2784<210> 2784

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2784<400> 2784

cucuucagaa gccaaccaga gaaacangua cauuaccugg ua 42cucuucagaa gccaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2785<210> 2785

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2785<400> 2785

uucgggagaa gggaaccaga gaaacangua cauuaccugg ua 42uucgggagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2786<210> 2786

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2786<400> 2786

cugugcagaa gcacaccaga gaaacangua cauuaccugg ua 42cugugcagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2787<210> 2787

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2787<400> 2787

ggagagagaa gcacaccaga gaaacangua cauuaccugg ua 42ggagagagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2788<210> 2788

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2788<400> 2788

caugggagaa gugaaccaga gaaacangua cauuaccugg ua 42caugggagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2789<210> 2789

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2789<400> 2789

ugccacagaa gguuaccaga gaaacangua cauuaccugg ua 42ugccacagaa gguuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2790<210> 2790

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2790<400> 2790

ggagggagaa gugaaccaga gaaacangua cauuaccugg ua 42ggagggagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2791<210> 2791

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2791<400> 2791

cugaagagaa ggccaccaga gaaacangua cauuaccugg ua 42cugaagagaa ggccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2792<210> 2792

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2792<400> 2792

gucagcagaa ggggaccaga gaaacangua cauuaccugg ua 42gucagcagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2793<210> 2793

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2793<400> 2793

gaugagagaa gcguaccaga gaaacangua cauuaccugg ua 42gaugagagaa gcguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2794<210> 2794

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2794<400> 2794

gcucgaagaa ggucaccaga gaaacangua cauuaccugg ua 42gcucgaagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2795<210> 2795

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2795<400> 2795

ugcugcagaa gauaaccaga gaaacangua cauuaccugg ua 42ugcugcagaa gauaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2796<210> 2796

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2796<400> 2796

guuguaagaa gggcaccaga gaaacangua cauuaccugg ua 42guuguaagaa gggcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2797<210> 2797

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2797<400> 2797

gacguaagaa ggacaccaga gaaacangua cauuaccugg ua 42gacguaagaa ggacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2798<210> 2798

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2798<400> 2798

gugguaagaa gcaaaccaga gaaacangua cauuaccugg ua 42gugguaagaa gcaaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2799<210> 2799

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2799<400> 2799

cguggaagaa guauaccaga gaaacangua cauuaccugg ua 42cguggaagaa guauaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2800<210> 2800

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2800<400> 2800

cagaacagaa guccaccaga gaaacangua cauuaccugg ua 42cagaacagaa guccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2801<210> 2801

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2801<400> 2801

cgccaaagaa gaagaccaga gaaacangua cauuaccugg ua 42cgccaaagaa gaagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2802<210> 2802

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2802<400> 2802

auccggagaa gccgaccaga gaaacangua cauuaccugg ua 42auccggagaa gccgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2803<210> 2803

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2803<400> 2803

ccgacgagaa ggagaccaga gaaacangua cauuaccugg ua 42ccgacgagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2804<210> 2804

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2804<400> 2804

gucaacagaa gacgaccaga gaaacangua cauuaccugg ua 42gucaacagaa gacgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2805<210> 2805

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2805<400> 2805

gcugucagaa gccgaccaga gaaacangua cauuaccugg ua 42gcugucagaa gccgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2806<210> 2806

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2806<400> 2806

gggaggagaa gucgaccaga gaaacangua cauuaccugg ua 42gggaggagaa gucgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2807<210> 2807

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2807<400> 2807

ggucugagaa ggagaccaga gaaacangua cauuaccugg ua 42ggucugagaa ggagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2808<210> 2808

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2808<400> 2808

ucagagagaa gaucaccaga gaaacangua cauuaccugg ua 42ucagagagaa gaucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2809<210> 2809

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2809<400> 2809

accgucagaa gaggaccaga gaaacangua cauuaccugg ua 42accgucagaa gaggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2810<210> 2810

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2810<400> 2810

cucaacagaa gauuaccaga gaaacangua cauuaccugg ua 42cucaacagaa gauuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2811<210> 2811

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2811<400> 2811

gcugagagaa ggguaccaga gaaacangua cauuaccugg ua 42gcugagagaa ggguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2812<210> 2812

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2812<400> 2812

uugagcagaa gacgaccaga gaaacangua cauuaccugg ua 42uugagcagaa gacgaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2813<210> 2813

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2813<400> 2813

acauugagaa gcagaccaga gaaacangua cauuaccugg ua 42acauugagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2814<210> 2814

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2814<400> 2814

ggcgugagaa gggcaccaga gaaacangua cauuaccugg ua 42ggcgugagaa gggcaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2815<210> 2815

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2815<400> 2815

uugaugagaa gcuuaccaga gaaacangua cauuaccugg ua 42uugaugagaa gcuuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2816<210> 2816

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2816<400> 2816

ugacgcagaa gagaaccaga gaaacangua cauuaccugg ua 42ugacgcagaa gagaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2817<210> 2817

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2817<400> 2817

cuugcaagaa gucaaccaga gaaacangua cauuaccugg ua 42cuugcaagaa gucaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2818<210> 2818

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2818<400> 2818

gggggcagaa gcuuaccaga gaaacangua cauuaccugg ua 42gggggcagaa gcuuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2819<210> 2819

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2819<400> 2819

acacggagaa gaugaccaga gaaacangua cauuaccugg ua 42acacggagaa gaugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2820<210> 2820

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2820<400> 2820

ucuuccagaa ggucaccaga gaaacangua cauuaccugg ua 42ucuuccagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2821<210> 2821

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2821<400> 2821

aaggcgagaa ggcuaccaga gaaacangua cauuaccugg ua 42aaggcgagaa ggcuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2822<210> 2822

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2822<400> 2822

ucccagagaa gggaaccaga gaaacangua cauuaccugg ua 42ucccagagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2823<210> 2823

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2823<400> 2823

acuggaagaa guacaccaga gaaacangua cauuaccugg ua 42acuggaagaa guacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2824<210> 2824

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2824<400> 2824

caaagcagaa ggugaccaga gaaacangua cauuaccugg ua 42caaagcagaa ggugaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2825<210> 2825

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2825<400> 2825

agucaaagaa gcggaccaga gaaacangua cauuaccugg ua 42agucaaagaa gcggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2826<210> 2826

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2826<400> 2826

auguagagaa gcucaccaga gaaacangua cauuaccugg ua 42auguagagaa gcucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2827<210> 2827

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2827<400> 2827

gaauuaagaa ggggaccaga gaaacangua cauuaccugg ua 42gaauuaagaa ggggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2828<210> 2828

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2828<400> 2828

cuagucagaa gcacaccaga gaaacangua cauuaccugg ua 42cuagucagaa gcacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2829<210> 2829

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2829<400> 2829

ucgacaagaa gcagaccaga gaaacangua cauuaccugg ua 42ucgacaagaa gcagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2830<210> 2830

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2830<400> 2830

cagcucagaa ggccaccaga gaaacangua cauuaccugg ua 42cagcucagaa ggccaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2831<210> 2831

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2831<400> 2831

ggggggagaa gaguaccaga gaaacangua cauuaccugg ua 42ggggggagaa gaguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2832<210> 2832

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2832<400> 2832

gguuggagaa ggucaccaga gaaacangua cauuaccugg ua 42gguuggagaa ggucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2833<210> 2833

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2833<400> 2833

gugcgcagaa gacaaccaga gaaacangua cauuaccugg ua 42gugcgcagaa gacaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2834<210> 2834

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2834<400> 2834

uuuucaagaa guucaccaga gaaacangua cauuaccugg ua 42uuuucaagaa guucaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2835<210> 2835

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2835<400> 2835

ccguagagaa gacaaccaga gaaacangua cauuaccugg ua 42ccguagagaa gacaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2836<210> 2836

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2836<400> 2836

ugaaugagaa gaggaccaga gaaacangua cauuaccugg ua 42ugaaugagaa gaggaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2837<210> 2837

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2837<400> 2837

cgcaagagaa guacaccaga gaaacangua cauuaccugg ua 42cgcaagagaa guacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2838<210> 2838

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2838<400> 2838

ccuuggagaa guagaccaga gaaacangua cauuaccugg ua 42ccuuggagaa guagaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2839<210> 2839

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2839<400> 2839

ggacgcagaa gggaaccaga gaaacangua cauuaccugg ua 42ggacgcagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2840<210> 2840

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2840<400> 2840

aaguccagaa gggaaccaga gaaacangua cauuaccugg ua 42aaguccagaa gggaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2841<210> 2841

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2841<400> 2841

cgaaccagaa ggacaccaga gaaacangua cauuaccugg ua 42cgaaccagaa ggacaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2842<210> 2842

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2842<400> 2842

gagacaagaa gugaaccaga gaaacangua cauuaccugg ua 42gagacaagaa gugaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2843<210> 2843

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2843<400> 2843

gcacgaagaa ggcuaccaga gaaacangua cauuaccugg ua 42gcacgaagaa ggcuaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2844<210> 2844

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2844<400> 2844

agcgggagaa ggcaaccaga gaaacangua cauuaccugg ua 42agcgggagaa ggcaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2845<210> 2845

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2845<400> 2845

uaaaccagaa ggguaccaga gaaacangua cauuaccugg ua 42uaaaccagaa ggguaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2846<210> 2846

＜211＞ 42<211> 42

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Hairpin Ribozyme<223> Synthesized HCV Hairpin Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem IV region of a HP ribozyme.<223> The letter "n" represents the stem IV region of a HP ribozyme.

＜400＞ 2846<400> 2846

uuggggagaa gguaaccaga gaaacangua cauuaccugg ua 42uuggggagaa gguaaccaga gaaacangua cauuaccugg ua 42

＜210＞ 2847<210> 2847

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2847<400> 2847

cccccgauug gggg 14cccccgauug gggg 14

＜210＞ 2848<210> 2848

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2848<400> 2848

cuacugucuu cacg 14cuacugucuu cacg 14

＜210＞ 2849<210> 2849

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2849<400> 2849

gugcagccuc cagg 14gugcagccuc cagg 14

＜210＞ 2850<210> 2850

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2850<400> 2850

aacccgcuca augc 14aacccgcuca augc 14

＜210＞ 2851<210> 2851

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2851<400> 2851

guacugccug auag 14guacugccug auag 14

＜210＞ 2852<210> 2852

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2852<400> 2852

cuaccgccgc ccac 14cuaccgccgc ccac 14

＜210＞ 2853<210> 2853

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2853<400> 2853

ccgccgccca cagg 14ccgccgccca cagg 14

＜210＞ 2854<210> 2854

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2854<400> 2854

ggucagaucg uugg 14ggucagaucg uugg 14

＜210＞ 2855<210> 2855

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2855<400> 2855

gaacggucgc aacc 14gaacggucgc aacc 14

＜210＞ 2856<210> 2856

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2856<400> 2856

ucgccgaccc gagg 14ucgccgaccc gagg 14

＜210＞ 2857<210> 2857

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2857<400> 2857

gcucagccug ggua 14gcucagccug ggua 14

＜210＞ 2858<210> 2858

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2858<400> 2858

ccgcggcucc cggc 14ccgcggcucc cggc 14

＜210＞ 2859<210> 2859

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2859<400> 2859

ucccggccua guug 14ucccggccua guug 14

＜210＞ 2860<210> 2860

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2860<400> 2860

ccacggaccc ccgg 14ccacggaccc ccgg 14

＜210＞ 2861<210> 2861

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2861<400> 2861

gugcggcuuc gccg 14gugcggcuuc gccg 14

＜210＞ 2862<210> 2862

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2862<400> 2862

ucgccgaccu caug 14ucgccgaccu caug 14

＜210＞ 2863<210> 2863

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2863<400> 2863

auuccgcucg ucgg 14auuccgcucg ucgg 14

＜210＞ 2864<210> 2864

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2864<400> 2864

gcccgguugc ucuu 14gcccgguugc ucuu 14

＜210＞ 2865<210> 2865

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2865<400> 2865

gcccugcugu ccug 14gcccugcugu ccug 14

＜210＞ 2866<210> 2866

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2866<400> 2866

cugcuguccu guuu 14cugcuguccu guuu 14

＜210＞ 2867<210> 2867

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2867<400> 2867

guccuguuug acca 14guccuguuug acca 14

＜210＞ 2868<210> 2868

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2868<400> 2868

ucccagcuuc cgcu 14ucccagcuuc cgcu 14

＜210＞ 2869<210> 2869

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2869<400> 2869

cuuccgcuua ucag 14cuuccgcuua ucag 14

＜210＞ 2870<210> 2870

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2870<400> 2870

ugacugcucc aacu 14ugacugcucc aacu 14

＜210＞ 2871<210> 2871

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2871<400> 2871

cucccguugu uggg 14cucccguugu uggg 14

＜210＞ 2872<210> 2872

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2872<400> 2872

gggcggccgc uuuc 14gggcggccgc uuuc 14

＜210＞ 2873<210> 2873

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2873<400> 2873

cggccgcuuu cugu 14cggccgcuuu cugu 14

＜210＞ 2874<210> 2874

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2874<400> 2874

uuucuguucc gcca 14uuucuguucc gcca 14

＜210＞ 2875<210> 2875

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2875<400> 2875

cugcggaucc guuu 14cugcggaucc guuu 14

＜210＞ 2876<210> 2876

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2876<400> 2876

gauccguuuu ccuc 14gauccguuuu ccuc 14

＜210＞ 2877<210> 2877

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2877<400> 2877

ucccaguugu ucac 14ucccaguugu ucac 14

＜210＞ 2878<210> 2878

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2878<400> 2878

caacagcccu agug 14caacagcccu agug 14

＜210＞ 2879<210> 2879

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2879<400> 2879

cuccggaucc caca 14cuccggaucc caca 14

＜210＞ 2880<210> 2880

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2880<400> 2880

aagcugucgu ggau 14aagcugucgu ggau 14

＜210＞ 2881<210> 2881

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2881<400> 2881

ggccggccca gaga 14ggccggccca gaga 14

＜210＞ 2882<210> 2882

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2882<400> 2882

auccagcuca uaaa 14auccagcuca uaaa 14

＜210＞ 2883<210> 2883

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2883<400> 2883

uggcagcugg caca 14uggcagcugg caca 14

＜210＞ 2884<210> 2884

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2884<400> 2884

ggacugcccu gaac 14ggacugcccu gaac 14

＜210＞ 2885<210> 2885

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2885<400> 2885

gcacuguucu acgc 14gcacuguucu acgc 14

＜210＞ 2886<210> 2886

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2886<400> 2886

guccggaugc ccag 14guccggaugc ccag 14

＜210＞ 2887<210> 2887

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2887<400> 2887

ggccagcugc agcu 14ggccagcugc agcu 14

＜210＞ 2888<210> 2888

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2888<400> 2888

cugcagcucc aucg 14cugcagcucc aucg 14

＜210＞ 2889<210> 2889

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2889<400> 2889

uuacugcugg cauu 14uuacugcugg cauu 14

＜210＞ 2890<210> 2890

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2890<400> 2890

guacuguuuc accc 14guacuguuuc accc 14

＜210＞ 2891<210> 2891

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2891<400> 2891

gcccuguugu agug 14gcccuguugu agug 14

＜210＞ 2892<210> 2892

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2892<400> 2892

cgaccgaucg gucc 14cgaccgaucg gucc 14

＜210＞ 2893<210> 2893

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2893<400> 2893

gaucgguccg gugc 14gaucgguccg gugc 14

＜210＞ 2894<210> 2894

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2894<400> 2894

agacagaugu gcug 14agacagaugu gcug 14

＜210＞ 2895<210> 2895

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2895<400> 2895

gugcugcuuc ucaa 14gugcugcuuc ucaa 14

＜210＞ 2896<210> 2896

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2896<400> 2896

acgcggccgc caca 14acgcggccgc caca 14

＜210＞ 2897<210> 2897

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2897<400> 2897

gaccugcccc acgg 14gaccugcccc acgg 14

＜210＞ 2898<210> 2898

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2898<400> 2898

ccacggauug cuuu 14ccacggauug cuuu 14

＜210＞ 2899<210> 2899

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2899<400> 2899

ggacagaucg gagc 14ggacagaucg gagc 14

＜210＞ 2900<210> 2900

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2900<400> 2900

gcucagcccg cugc 14gcucagcccg cugc 14

＜210＞ 2901<210> 2901

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2901<400> 2901

agcccgcugc ugcu 14agcccgcugc ugcu 14

＜210＞ 2902<210> 2902

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2902<400> 2902

ccgcugcugc uguc 14ccgcugcugc uguc 14

＜210＞ 2903<210> 2903

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2903<400> 2903

cugcugcugu ccac 14cugcugcugu ccac 14

＜210＞ 2904<210> 2904

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2904<400> 2904

cugcugucca cgac 14cugcugucca cgac 14

＜210＞ 2905<210> 2905

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2905<400> 2905

ucccuguucc uuca 14ucccuguucc uuca 14

＜210＞ 2906<210> 2906

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2906<400> 2906

uaccggcucu gucc 14uaccggcucu gucc 14

＜210＞ 2907<210> 2907

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2907<400> 2907

gcucugucca cugg 14gcucugucca cugg 14

＜210＞ 2908<210> 2908

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2908<400> 2908

cagcgguugu cucc 14cagcgguugu cucc 14

＜210＞ 2909<210> 2909

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2909<400> 2909

uggcggacgc gcgc 14uggcggacgc gcgc 14

＜210＞ 2910<210> 2910

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2910<400> 2910

ugccugcuug ugga 14ugccugcuug ugga 14

＜210＞ 2911<210> 2911

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2911<400> 2911

augcugcuga uagc 14augcugcuga uagc 14

＜210＞ 2912<210> 2912

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2912<400> 2912

aggccgcccu agag 14aggccgcccu agag 14

＜210＞ 2913<210> 2913

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2913<400> 2913

gagcggaugg cauu 14gagcggaugg cauu 14

＜210＞ 2914<210> 2914

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2914<400> 2914

gugccgccug guac 14gugccgccug guac 14

＜210＞ 2915<210> 2915

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2915<400> 2915

uggccgcugc uccu 14uggccgcugc uccu 14

＜210＞ 2916<210> 2916

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2916<400> 2916

ccgcugcucc ugcu 14ccgcugcucc ugcu 14

＜210＞ 2917<210> 2917

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2917<400> 2917

cuccugcucc ugcu 14cuccugcucc ugcu 14

＜210＞ 2918<210> 2918

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2918<400> 2918

cuccugcugg cguu 14cuccugcugg cguu 14

＜210＞ 2919<210> 2919

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2919<400> 2919

gugcggccca ccca 14gugcggccca ccca 14

＜210＞ 2920<210> 2920

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2920<400> 2920

cuccugcucg ccau 14cuccugcucg ccau 14

＜210＞ 2921<210> 2921

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2921<400> 2921

ucucgguccg cuca 14ucucgguccg cuca 14

＜210＞ 2922<210> 2922

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2922<400> 2922

gguccgcuca uggu 14gguccgcuca uggu 14

＜210＞ 2923<210> 2923

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2923<400> 2923

agcccgucgu cuuc 14agcccgucgu cuuc 14

＜210＞ 2924<210> 2924

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2924<400> 2924

ggacugcccg ucuc 14ggacugcccg ucuc 14

＜210＞ 2925<210> 2925

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2925<400> 2925

ugcccgucuc cgcc 14ugcccgucuc cgcc 14

＜210＞ 2926<210> 2926

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2926<400> 2926

ucuccgcccg aagg 14ucuccgcccg aagg 14

＜210＞ 2927<210> 2927

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2927<400> 2927

gaccggccga uagc 14gaccggccga uagc 14

＜210＞ 2928<210> 2928

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2928<400> 2928

ucacggccua cgcc 14ucacggccua cgcc 14

＜210＞ 2929<210> 2929

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2929<400> 2929

ggaccgucuu ccac 14ggaccgucuu ccac 14

＜210＞ 2930<210> 2930

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2930<400> 2930

cgccggcuca aaga 14cgccggcuca aaga 14

＜210＞ 2931<210> 2931

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2931<400> 2931

agccggccca aaag 14agccggccca aaag 14

＜210＞ 2932<210> 2932

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2932<400> 2932

cgucggcugg caug 14cgucggcugg caug 14

＜210＞ 2933<210> 2933

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2933<400> 2933

gcucggaccu cuau 14gcucggaccu cuau 14

＜210＞ 2934<210> 2934

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2934<400> 2934

augcugacgu cauu 14augcugacgu cauu 14

＜210＞ 2935<210> 2935

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2935<400> 2935

gcgccgacgc ggug 14gcgccgacgc ggug 14

＜210＞ 2936<210> 2936

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2936<400> 2936

ugacggucgg ggga 14ugacggucgg ggga 14

＜210＞ 2937<210> 2937

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2937<400> 2937

cuacuguccc ccag 14cuacuguccc ccag 14

＜210＞ 2938<210> 2938

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2938<400> 2938

ccccagaccc gucu 14ccccagaccc gucu 14

＜210＞ 2939<210> 2939

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2939<400> 2939

gacccgucuc cuau 14gacccgucuc cuau 14

＜210＞ 2940<210> 2940

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2940<400> 2940

ccacugcucu gccc 14ccacugcucu gccc 14

＜210＞ 2941<210> 2941

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2941<400> 2941

gcucugcccu ucgg 14gcucugcccu ucgg 14

＜210＞ 2942<210> 2942

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2942<400> 2942

gggcugcugu gugc 14gggcugcugu gugc 14

＜210＞ 2943<210> 2943

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2943<400> 2943

uacccguuga gucu 14uacccguuga gucu 14

＜210＞ 2944<210> 2944

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2944<400> 2944

augcgguccc cggu 14augcgguccc cggu 14

＜210＞ 2945<210> 2945

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2945<400> 2945

ccccggucuu cacg 14ccccggucuu cacg 14

＜210＞ 2946<210> 2946

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2946<400> 2946

ccccggccgu accg 14ccccggccgu accg 14

＜210＞ 2947<210> 2947

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2947<400> 2947

ugccggcugc guac 14ugccggcugc guac 14

＜210＞ 2948<210> 2948

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2948<400> 2948

acgcagccca aggg 14acgcagccca aggg 14

＜210＞ 2949<210> 2949

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2949<400> 2949

caucuguugc cgcc 14caucuguugc cgcc 14

＜210＞ 2950<210> 2950

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2950<400> 2950

guaccgaccc caac 14guaccgaccc caac 14

＜210＞ 2951<210> 2951

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2951<400> 2951

uugccgacgg ugga 14uugccgacgg ugga 14

＜210＞ 2952<210> 2952

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2952<400> 2952

caacugacuc gacu 14caacugacuc gacu 14

＜210＞ 2953<210> 2953

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2953<400> 2953

gcacaguccu ggac 14gcacaguccu ggac 14

＜210＞ 2954<210> 2954

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2954<400> 2954

agacggcugg agcg 14agacggcugg agcg 14

＜210＞ 2955<210> 2955

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2955<400> 2955

gcgcggcucg ucgu 14gcgcggcucg ucgu 14

＜210＞ 2956<210> 2956

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2956<400> 2956

gcucugucca acac 14gcucugucca acac 14

＜210＞ 2957<210> 2957

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2957<400> 2957

auaccgacua gcgg 14auaccgacua gcgg 14

＜210＞ 2958<210> 2958

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2958<400> 2958

caacagacgc ucua 14caacagacgc ucua 14

＜210＞ 2959<210> 2959

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2959<400> 2959

agacagucga uuuc 14agacagucga uuuc 14

＜210＞ 2960<210> 2960

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2960<400> 2960

uuucagcuug gauc 14uuucagcuug gauc 14

＜210＞ 2961<210> 2961

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2961<400> 2961

gaacggcccu cggg 14gaacggcccu cggg 14

＜210＞ 2962<210> 2962

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2962<400> 2962

cuucgguccu gugu 14cuucgguccu gugu 14

＜210＞ 2963<210> 2963

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2963<400> 2963

cgcccgcuga gacu 14cgcccgcuga gacu 14

＜210＞ 2964<210> 2964

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2964<400> 2964

ugcccgucug ccag 14ugcccgucug ccag 14

＜210＞ 2965<210> 2965

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2965<400> 2965

uuccuguccc aaac 14uuccuguccc aaac 14

＜210＞ 2966<210> 2966

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2966<400> 2966

auacggcuua aacc 14auacggcuua aacc 14

＜210＞ 2967<210> 2967

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2967<400> 2967

ccccugcugu auag 14ccccugcugu auag 14

＜210＞ 2968<210> 2968

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2968<400> 2968

gagccguuca aaau 14gagccguuca aaau 14

＜210＞ 2969<210> 2969

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2969<400> 2969

ugucggccga ccug 14ugucggccga ccug 14

＜210＞ 2970<210> 2970

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2970<400> 2970

cggccgaccu ggag 14cggccgaccu ggag 14

＜210＞ 2971<210> 2971

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2971<400> 2971

uugcagcucu ggcc 14uugcagcucu ggcc 14

＜210＞ 2972<210> 2972

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2972<400> 2972

ggccggcugu uguu 14ggccggcugu uguu 14

＜210＞ 2973<210> 2973

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2973<400> 2973

cggcuguugu uccc 14cggcuguugu uccc 14

＜210＞ 2974<210> 2974

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2974<400> 2974

augcagcucg ccga 14augcagcucg ccga 14

＜210＞ 2975<210> 2975

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2975<400> 2975

gagcaguuca agca 14gagcaguuca agca 14

＜210＞ 2976<210> 2976

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2976<400> 2976

aggccgcugc uccc 14aggccgcugc uccc 14

＜210＞ 2977<210> 2977

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2977<400> 2977

ccgcugcucc cgug 14ccgcugcucc cgug 14

＜210＞ 2978<210> 2978

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2978<400> 2978

acucugccug ggaa 14acucugccug ggaa 14

＜210＞ 2979<210> 2979

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2979<400> 2979

ucacugaugg cauu 14ucacugaugg cauu 14

＜210＞ 2980<210> 2980

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2980<400> 2980

ucacagccuc uauc 14ucacagccuc uauc 14

＜210＞ 2981<210> 2981

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2981<400> 2981

caccaguccg cuca 14caccaguccg cuca 14

＜210＞ 2982<210> 2982

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2982<400> 2982

aguccgcuca ccac 14aguccgcuca ccac 14

＜210＞ 2983<210> 2983

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2983<400> 2983

cuccuguuca acau 14cuccuguuca acau 14

＜210＞ 2984<210> 2984

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2984<400> 2984

uggcugcuca acuc 14uggcugcuca acuc 14

＜210＞ 2985<210> 2985

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2985<400> 2985

gugcugcuuc ggcc 14gugcugcuuc ggcc 14

＜210＞ 2986<210> 2986

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2986<400> 2986

cuucggccuu cgug 14cuucggccuu cgug 14

＜210＞ 2987<210> 2987

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2987<400> 2987

ccuccgccga ggac 14ccuccgccga ggac 14

＜210＞ 2988<210> 2988

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2988<400> 2988

aaccggcuga uagc 14aaccggcuga uagc 14

＜210＞ 2989<210> 2989

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2989<400> 2989

acucagaucc ucuc 14acucagaucc ucuc 14

＜210＞ 2990<210> 2990

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2990<400> 2990

cuccagccuc acca 14cuccagccuc acca 14

＜210＞ 2991<210> 2991

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2991<400> 2991

acucagcugc ugaa 14acucagcugc ugaa 14

＜210＞ 2992<210> 2992

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2992<400> 2992

cagcugcuga agag 14cagcugcuga agag 14

＜210＞ 2993<210> 2993

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2993<400> 2993

ggacugcucc acgc 14ggacugcucc acgc 14

＜210＞ 2994<210> 2994

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2994<400> 2994

cuccggcucg uggc 14cuccggcucg uggc 14

＜210＞ 2995<210> 2995

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2995<400> 2995

ugacugacuu caag 14ugacugacuu caag 14

＜210＞ 2996<210> 2996

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2996<400> 2996

cuccagucca agcu 14cuccagucca agcu 14

＜210＞ 2997<210> 2997

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2997<400> 2997

cuccugccga aauu 14cuccugccga aauu 14

＜210＞ 2998<210> 2998

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2998<400> 2998

caccugccca ugug 14caccugccca ugug 14

＜210＞ 2999<210> 2999

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 2999<400> 2999

aaacgguucc auga 14aaacgguucc auga 14

＜210＞ 3000<210> 3000

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3000<400> 3000

uggcugcuga agag 14uggcugcuga agag 14

＜210＞ 3001<210> 3001

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3001<400> 3001

ucccggcccc cgaa 14ucccggcccc cgaa 14

＜210＞ 3002<210> 3002

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3002<400> 3002

gugcgguugc acag 14gugcgguugc acag 14

＜210＞ 3003<210> 3003

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3003<400> 3003

gugcagaccu cucc 14gugcagaccu cucc 14

＜210＞ 3004<210> 3004

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3004<400> 3004

ucacagcucc caug 14ucacagcucc caug 14

＜210＞ 3005<210> 3005

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3005<400> 3005

aaccggaugu ggca 14aaccggaugu ggca 14

＜210＞ 3006<210> 3006

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3006<400> 3006

ucaccgaccc cucc 14ucaccgaccc cucc 14

＜210＞ 3007<210> 3007

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3007<400> 3007

ggccagcucu ucag 14ggccagcucu ucag 14

＜210＞ 3008<210> 3008

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3008<400> 3008

ccccggacgc ugac 14ccccggacgc ugac 14

＜210＞ 3009<210> 3009

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3009<400> 3009

acgcugaccu cauc 14acgcugaccu cauc 14

＜210＞ 3010<210> 3010

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3010<400> 3010

gacccgcuuc gagc 14gacccgcuuc gagc 14

＜210＞ 3011<210> 3011

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3011<400> 3011

uauccguugc agca 14uauccguugc agca 14

＜210＞ 3012<210> 3012

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3012<400> 3012

gcccggauua caac 14gcccggauua caac 14

＜210＞ 3013<210> 3013

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3013<400> 3013

guccggacua cguc 14guccggacua cguc 14

＜210＞ 3014<210> 3014

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3014<400> 3014

uugccgccua ccac 14uugccgccua ccac 14

＜210＞ 3015<210> 3015

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3015<400> 3015

auaccgccuc cacg 14auaccgccuc cacg 14

＜210＞ 3016<210> 3016

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3016<400> 3016

ggacgguugu ucug 14ggacgguugu ucug 14

＜210＞ 3017<210> 3017

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3017<400> 3017

cuucugccuu ggcg 14cuucugccuu ggcg 14

＜210＞ 3018<210> 3018

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3018<400> 3018

cggcagcucc ggau 14cggcagcucc ggau 14

＜210＞ 3019<210> 3019

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3019<400> 3019

cuccggaucg ucgg 14cuccggaucg ucgg 14

＜210＞ 3020<210> 3020

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3020<400> 3020

cgucggccgu ugac 14cgucggccgu ugac 14

＜210＞ 3021<210> 3021

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3021<400> 3021

cggccguuga cagc 14cggccguuga cagc 14

＜210＞ 3022<210> 3022

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3022<400> 3022

cgaccgcccc uccc 14cgaccgcccc uccc 14

＜210＞ 3023<210> 3023

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3023<400> 3023

cucccgauca gacc 14cucccgauca gacc 14

＜210＞ 3024<210> 3024

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3024<400> 3024

gaucagaccu cuga 14gaucagaccu cuga 14

＜210＞ 3025<210> 3025

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3025<400> 3025

ccucugacga cggu 14ccucugacga cggu 14

＜210＞ 3026<210> 3026

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3026<400> 3026

aaucugacgu ugag 14aaucugacgu ugag 14

＜210＞ 3027<210> 3027

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3027<400> 3027

acccugaucu cagc 14acccugaucu cagc 14

＜210＞ 3028<210> 3028

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3028<400> 3028

cgucugcugc ucaa 14cgucugcugc ucaa 14

＜210＞ 3029<210> 3029

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3029<400> 3029

cugcugcuca augu 14cugcugcuca augu 14

＜210＞ 3030<210> 3030

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3030<400> 3030

gcccugauca cgcc 14gcccugauca cgcc 14

＜210＞ 3031<210> 3031

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3031<400> 3031

aagcugccca ucaa 14aagcugccca ucaa 14

＜210＞ 3032<210> 3032

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3032<400> 3032

ucucugcugc guca 14ucucugcugc guca 14

＜210＞ 3033<210> 3033

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3033<400> 3033

ugacagacug caag 14ugacagacug caag 14

＜210＞ 3034<210> 3034

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3034<400> 3034

aagcugacgc cccc 14aagcugacgc cccc 14

＜210＞ 3035<210> 3035

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3035<400> 3035

cauccgcucc gugu 14cauccgcucc gugu 14

＜210＞ 3036<210> 3036

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3036<400> 3036

gaccugcugg aaga 14gaccugcugg aaga 14

＜210＞ 3037<210> 3037

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3037<400> 3037

agccagcucg ccuu 14agccagcucg ccuu 14

＜210＞ 3038<210> 3038

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3038<400> 3038

ucccagaccu ggga 14ucccagaccu ggga 14

＜210＞ 3039<210> 3039

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3039<400> 3039

guacggauuc cagu 14guacggauuc cagu 14

＜210＞ 3040<210> 3040

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3040<400> 3040

cacccgcugc uuug 14cacccgcugc uuug 14

＜210＞ 3041<210> 3041

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3041<400> 3041

ccgcugcuuu gacu 14ccgcugcuuu gacu 14

＜210＞ 3042<210> 3042

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3042<400> 3042

gagcggcucu acau 14gagcggcucu acau 14

＜210＞ 3043<210> 3043

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3043<400> 3043

ccccugacua auuc 14ccccugacua auuc 14

＜210＞ 3044<210> 3044

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3044<400> 3044

gugcugacga cuag 14gugcugacga cuag 14

＜210＞ 3045<210> 3045

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3045<400> 3045

cugcggccug ucga 14cugcggccug ucga 14

＜210＞ 3046<210> 3046

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3046<400> 3046

ggccugucga gcug 14ggccugucga gcug 14

＜210＞ 3047<210> 3047

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3047<400> 3047

acucugcccc cccc 14acucugcccc cccc 14

＜210＞ 3048<210> 3048

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3048<400> 3048

gacccgcccc aacc 14gacccgcccc aacc 14

＜210＞ 3049<210> 3049

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3049<400> 3049

ugucggucgc gcac 14ugucggucgc gcac 14

＜210＞ 3050<210> 3050

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3050<400> 3050

gaacagcuug aaaa 14gaacagcuug aaaa 14

＜210＞ 3051<210> 3051

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3051<400> 3051

ugucagaucu acgg 14ugucagaucu acgg 14

＜210＞ 3052<210> 3052

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3052<400> 3052

ccucagauca uuca 14ccucagauca uuca 14

＜210＞ 3053<210> 3053

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3053<400> 3053

guaccgcccu ugcg 14guaccgcccu ugcg 14

＜210＞ 3054<210> 3054

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3054<400> 3054

cuacuguccc aagg 14cuacuguccc aagg 14

＜210＞ 3055<210> 3055

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3055<400> 3055

ucccggccgc gucc 14ucccggccgc gucc 14

＜210＞ 3056<210> 3056

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3056<400> 3056

ucccagcugg acuu 14ucccagcugg acuu 14

＜210＞ 3057<210> 3057

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3057<400> 3057

guccagcugg uucg 14guccagcugg uucg 14

＜210＞ 3058<210> 3058

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3058<400> 3058

ucacagccug ucuc 14ucacagccug ucuc 14

＜210＞ 3059<210> 3059

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3059<400> 3059

agccugucuc gugc 14agccugucuc gugc 14

＜210＞ 3060<210> 3060

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3060<400> 3060

ugcccgaccc cgcu 14ugcccgaccc cgcu 14

＜210＞ 3061<210> 3061

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3061<400> 3061

accccgcugg uuua 14accccgcugg uuua 14

＜210＞ 3062<210> 3062

＜211＞ 14<211> 14

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3062<400> 3062

uaccugcucc ccaa 14uaccugcucc ccaa 14

＜210＞ 3063<210> 3063

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3063<400> 3063

uuggugucug augagncgaa acguuug 27uuggugucug augagncgaa acguuug 27

＜210＞ 3064<210> 3064

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3064<400> 3064

ugugggccug augagncgaa acgguug 27ugugggccug augagncgaa acgguug 27

＜210＞ 3065<210> 3065

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3065<400> 3065

agguugucug augagncgaa accgcuc 27agguugucug augagncgaa accgcuc 27

＜210＞ 3066<210> 3066

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3066<400> 3066

aaaaaaacug augagncgaa aaaaaaa 27aaaaaaacug augagncgaa aaaaaaa 27

＜210＞ 3067<210> 3067

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3067<400> 3067

uaagaugcug augagncgaa agccacc 27uaagaugcug augagncgaa agccacc 27

＜210＞ 3068<210> 3068

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3068<400> 3068

gggcuaacug augagncgaa auggagc 27gggcuaacug augagncgaa auggagc 27

＜210＞ 3069<210> 3069

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3069<400> 3069

uagggcucug augagncgaa agaugga 27uagggcucug augagncgaa agaugga 27

＜210＞ 3070<210> 3070

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3070<400> 3070

cuagggccug augagncgaa aagaugg 27cuagggccug augagncgaa aagaugg 27

＜210＞ 3071<210> 3071

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3071<400> 3071

ccgugaccug augagncgaa agggcua 27ccgugaccug augagncgaa agggcua 27

＜210＞ 3072<210> 3072

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3072<400> 3072

uagccgucug augagncgaa acuaggg 27uagccgucug augagncgaa acuaggg 27

＜210＞ 3073<210> 3073

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3073<400> 3073

ucacagccug augagncgaa agccgug 27ucacagccug augagncgaa agccgug 27

＜210＞ 3074<210> 3074

＜211＞ 27<211> 27

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized HCV Conserved Hammerhead Ribozyme<223> Synthesized HCV Conserved Hammerhead Ribozyme

＜220＞<220>

＜223＞ The letter "n" represents the stem II region of a HH ribozyme.<223> The letter "n" represents the stem II region of a HH ribozyme.

＜400＞ 3074<400> 3074

gcucacgcug augagncgaa accuuuc 27gcucacgcug augagncgaa accuuuc 27

＜210＞ 3075<210> 3075

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3075<400> 3075

caaacguaac accaa 15caaacguaac accaa 15

＜210＞ 3076<210> 3076

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3076<400> 3076

caaccgucgc ccaca 15caaccgucgc ccaca 15

＜210＞ 3077<210> 3077

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3077<400> 3077

gagcggucac aaccu 15gagcggucac aaccu 15

＜210＞ 3078<210> 3078

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3078<400> 3078

uuuuuuuuuu uuuuu 15uuuuuuuuuu uuuuu 15

＜210＞ 3079<210> 3079

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3079<400> 3079

gguggcucca ucuua 15gguggcucca ucuua 15

＜210＞ 3080<210> 3080

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3080<400> 3080

gcuccaucuu agccc 15gcuccaucuu agccc 15

＜210＞ 3081<210> 3081

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3081<400> 3081

uccaucuuag cccua 15uccaucuuag cccua 15

＜210＞ 3082<210> 3082

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3082<400> 3082

ccaucuuagc ccuag 15ccaucuuagc ccuag 15

＜210＞ 3083<210> 3083

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3083<400> 3083

uagcccuagu cacgg 15uagcccuagu cacgg 15

＜210＞ 3084<210> 3084

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3084<400> 3084

cccuagucac ggcua 15cccuagucac ggcua 15

＜210＞ 3085<210> 3085

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3085<400> 3085

cacggcuagc uguga 15cacggcuagc uguga 15

＜210＞ 3086<210> 3086

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3086<400> 3086

gaaagguccg ugagc 15gaaagguccg ugagc 15

＜210＞ 3087<210> 3087

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3087<400> 3087

auccuugaug gcauacacua ugcgcgauga ucugca 36auccuugaug gcauacacua ugcgcgauga ucugca 36

＜210＞ 3088<210> 3088

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3088<400> 3088

acacuugaug gcaugcacua ugcgcgauac uaacgc 36acacuugaug gcaugcacua ugcgcgauac uaacgc 36

＜210＞ 3089<210> 3089

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3089<400> 3089

cacgaugaug gcaugcacua ugcgcgacuc auacua 36cacgaugaug gcaugcacua ugcgcgacuc auacua 36

＜210＞ 3090<210> 3090

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3090<400> 3090

ggcugugaug gcaugcacua ugcgcgacga cacuca 36ggcugugaug gcaugcacua ugcgcgacga cacuca 36

＜210＞ 3091<210> 3091

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3091<400> 3091

cccaaugaug gcaugcacua ugcgcgacua cucggc 36cccaaugaug gcaugcacua ugcgcgacua cucggc 36

＜210＞ 3092<210> 3092

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3092<400> 3092

uuucgugaug gcaugcacua ugcgcggacc caacac 36uuucgugaug gcaugcacua ugcgcggacc caacac 36

＜210＞ 3093<210> 3093

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3093<400> 3093

ucaggugaug gcaugcacua ugcgcgagua ccacaa 36ucaggugaug gcaugcacua ugcgcgagua ccacaa 36

＜210＞ 3094<210> 3094

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3094<400> 3094

gcacuugaug gcaugcacua ugcgcggcaa gcaccc 36gcacuugaug gcaugcacua ugcgcggcaa gcaccc 36

＜210＞ 3095<210> 3095

＜211＞ 32<211> 32

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence ＜220＞<213> Artificial Sequence <220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3095<400> 3095

auuccacnag ugaggcguua gccgauacgc ga 32auuccacnag ugaggcguua gccgauacgc ga 32

＜210＞ 3096<210> 3096

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜220＞<220>

＜223＞ The letter "n" in position 9 represents 2'-C-Allyl-U;<223> The letter "n" in position 9 represents 2'-C-Allyl-U;

The letter "n" in position 30 represents a ribo inosine.The letter "n" in position 30 represents a ribo inosine.

＜400＞ 3096<400> 3096

uccucaccng augaggccgu uaggccgaan gggagu 36uccucaccng augaggccgu uaggccgaan gggagu 36

＜210＞ 3097<210> 3097

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜220＞<220>

＜223＞ The letter "n" in position 9 represents an 2'-C-Allyl-U;<223> The letter "n" in position 9 represents an 2'-C-Allyl-U;

The letter "n" in position 30 represents a ribo inosine.The letter "n" in position 30 represents a ribo inosine.

＜400＞ 3097<400> 3097

guccuggcng augaggccgu uaggccgaan gcugca 36guccuggcng augaggccgu uaggccgaan gcugca 36

＜210＞ 3098<210> 3098

＜211＞ 53<211> 53

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3098<400> 3098

ggaaaggugu gcaaccggag gaaacucccu ucaaggacau cguccgggac ggc 53ggaaaggugu gcaaccggag gaaacucccu ucaaggacau cguccgggac ggc 53

＜210＞ 3099<210> 3099

＜211＞ 50<211> 50

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3099<400> 3099

uuccgcagac ggaggaaacu cccuucaagg acgaaagucc gggacuaugg 50uuccgcagac ggaggaaacu cccuucaagg acgaaagucc gggacuaugg 50

＜210＞ 3100<210> 3100

＜211＞ 48<211> 48

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3100<400> 3100

ccgcagacgg aggaaacucc cuucaaggac gaaaguccgg gacuaugg 48ccgcagacgg aggaaacucc cuucaaggac gaaaguccgg gacuaugg 48

＜210＞ 3101<210> 3101

＜211＞ 48<211> 48

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3101<400> 3101

cagguaguac ggaggaaacu cccuucaagg acaucguccg ggacaagg 48cagguaguac ggaggaaacu cccuucaagg acaucguccg ggacaagg 48

＜210＞ 3102<210> 3102

＜211＞ 48<211> 48

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3102<400> 3102

gcacggucua ggaggaaacu cccuucaagg acaucguccg gggagacc 48gcacggucua ggaggaaacu cccuucaagg acaucguccg gggagacc 48

＜210＞ 3103<210> 3103

＜211＞ 47<211> 47

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Ribozyme Motifs<223> Synthesized Ribozyme Motifs

＜400＞ 3103<400> 3103

guguacucac ggaggaaacu cccuucaagg acaucguccg gggguuc 47guguacucac ggaggaaacu cccuucaagg acaucguccg gggguuc 47

＜210＞ 3104<210> 3104

＜211＞ 23<211> 23

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜400＞ 3104<400> 3104

gaaaugcaaa guuccagaau cgg 23gaaaugcaaa guuccagaau cgg 23

＜210＞ 3105<210> 3105

＜211＞ 17<211> 17

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜400＞ 3105<400> 3105

uccucgcugg ggcuaag 17uccucgcugg ggcuaag 17

＜210＞ 3106<210> 3106

＜211＞ 13<211> 13

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base.<223> The letter "n" stands for any base.

＜400＞ 3106<400> 3106

cugangagcg aaa 13cugangagcg aaa 13

＜210＞ 3107<210> 3107

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base;<223> The letter "n" stands for any base;

The letter "y" stands for c or u;The letter "y" stands for c or u;

The letter "h" stands for a, c or u.The letter "h" stands for a, c or u.

＜400＞ 3107<400> 3107

nnnnnnnyng hynnn 15nnnnnnnyng hynnn 15

＜210＞ 3108<210> 3108

＜211＞ 47<211> 47

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base;<223> The letter "n" stands for any base;

The letter "h" stands for a, c or u.The letter "h" stands for a, c or u.

＜400＞ 3108<400> 3108

nnnngaagnn nnnnnnnnna aahannnnnn nacauuacnn nnnnnnn 47nnnngaagnn nnnnnnnnna aahannnnnn nacauuacnn nnnnnnn 47

＜210＞ 3109<210> 3109

＜211＞ 15<211> 15

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3109<400> 3109

ggguccuuuc uugga 15ggguccuuuc uugga 15

＜210＞ 3110<210> 3110

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 3110<400> 3110

uccaagacug augaggccgu uaggccgaaa ggaccc 36uccaagacug augaggccgu uaggccgaaa ggaccc 36

＜210＞ 3111<210> 3111

＜211＞ 34<211> 34

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 3111<400> 3111

uccaagacug augaggcguu agccgaaagg accc 34uccaagacug augaggcguu agccgaaagg accc 34

＜210＞ 3112<210> 3112

＜211＞ 13<211> 13

＜212＞ RNA<212> RNA

＜213＞ Hepatitis C Virus<213> Hepatitis C Virus

＜400＞ 3112<400> 3112

gguccuuucu ugg 13gguccuuucu ugg 13

＜210＞ 3113<210> 3113

＜211＞ 34<211> 34

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 3113<400> 3113

ccaagacuga ugaggccguu aggccgaaag gacc 34ccaagacuga ugaggccguu aggccgaaag gacc 34

＜210＞ 3114<210> 3114

＜211＞ 32<211> 32

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized Hammerhead Ribozyme<223> Synthesized Hammerhead Ribozyme

＜400＞ 3114<400> 3114

ccaagacuga ugaggcguua gccgaaagga cc 32ccaagacuga ugaggcguua gccgaaagga cc 32

＜210＞ 3115<210> 3115

＜211＞ 54<211> 54

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base<223> The letter "n" stands for any base

＜400＞ 3115<400> 3115

nnnnnnnnnn nnnnnnggag gaaacucccu ucaaggacga aaguccgggn nnnn 54nnnnnnnnnn nnnnnnggag gaaacucccu ucaaggacga aaguccgggn nnnn 54

＜210＞ 3116<210> 3116

＜211＞ 18<211> 18

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base<223> The letter "n" stands for any base

＜400＞ 3116<400> 3116

nnnnngnnnn nnnnnnnn 18nnnnngnnnn nnnnnnnn 18

＜210＞ 3117<210> 3117

＜211＞ 35<211> 35

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base<223> The letter "n" stands for any base

＜400＞ 3117<400> 3117

nnnnnnncug augagnnnga aannncgaan nnnnn 35nnnnnnncug augagnnnga aannncgaan nnnnn 35

＜210＞ 3118<210> 3118

＜211＞ 36<211> 36

＜212＞ RNA<212> RNA

＜213＞ Artificial Sequence<213> Artificial Sequence

＜220＞<220>

＜223＞ Synthesized nucleic acid molecule<223> Synthesized nucleic acid molecule

＜220＞<220>

＜223＞ The letter "n" stands for any base;<223> The letter "n" stands for any base;

The letter "s" stands for c or g.The letter "s" stands for c or g.

＜400＞ 3118<400> 3118

nnnnnnnuga usgggaugaa cuauccgcgn nnnnnn 36nnnnnnnuga usgggaugaa cuauccgcgn nnnnnn 36

본 특허 출원은 블랫(Blatt) 등의 1999년 2월 24일 출원된 미국 출원(번호 미지정), 블랫(Blatt) 등의 1998년 9월 18일 출원된 미국 특허 제 60/100,842호, 및 맥스위겐(McSwiggen) 등의 1998년 4월 27일 출원된 미국 특허 제 60/083,217호에 대하여 우선권을 주장하며, 이들 이전의 출원의 명칭은 모두 "C형 간염 바이러스성 감염과 관련된 질환의 효소적 핵산 치료제"이다. 이들 출원 각각은 도면을 포함한 전문이 본원에 참고문헌으로 삽입된다.This patent application is filed on Feb. 24, 1999, filed by Blatt et al., U.S. Patent No. 60 / 100,842, filed on September 18, 1998, by Blatt et al., And Maxwigen. (McSwiggen) et al., Claims priority to U.S. Patent No. 60 / 083,217, filed April 27, 1998, all of which are entitled "Enzymatic Nucleic Acid Therapeutics for Diseases Associated with Hepatitis C Viral Infection. "to be. Each of these applications is incorporated herein by reference in their entirety, including the drawings.

발명의 배경Background of the Invention

본 발명은 C형 간염 바이러스성 감염과 관련된 질환의 치료 방법 및 치료제에 관한 것이다.The present invention relates to a method and therapeutic agent for a disease associated with hepatitis C viral infection.

하기 설명은 본 발명보다 선행되는 것으로 인정되지 않는 관련 기술에 관한 검토이다.The following description is a review of the related art, which is not recognized as prior to the present invention.

1989년, HCV는 RNA 바이러스로 결정되었고 대부분의 비-A 비-B형 바이러스성 간염의 원인 인자로서 확인되었다[참조: Choo et al., Science. 1989; 244: 359-362]. HIV와 같은 레트로바이러스와는 달리, HCV는 DNA 복제기를 거치지 않으며 숙주 염색체에 혼입된 형태의 바이러스 게놈은 검출되지 않았다[참조: Houghton et al., Hepatology 1991; 14: 381-388]. 오히려, 코딩(+) 가닥의 복제는 (+) 가닥 HCV RNA의 수개의 복제물을 생성시키는 복제성(-) 가닥의 생성에 의해 매개된다. 게놈은 폴리단백질로 번역되는 단일의 거대한 개방 해독 구조로 구성된다[Kato et al., FEBS Letters. 1991; 280: 325-328]. 이 폴리단백질은 후속하여 번역후 절단을 거쳐 수개의 바이러스 단백질을 생성한다[참조: Leinbach et al., 1994: 204: 163-169].In 1989, HCV was determined to be an RNA virus and has been identified as a causative agent of most non-A non-B viral hepatitis. Choo et al., Science. 1989; 244: 359-362. Unlike retroviruses such as HIV, HCV does not go through a DNA replicator and no viral genome has been detected that has been incorporated into the host chromosome (Houghton et al., Hepatology 1991; 14: 381-388. Rather, the replication of the coding (+) strand is mediated by the generation of a replicative (-) strand that produces several copies of the (+) strand HCV RNA. The genome consists of a single large open reading structure that is translated into polyproteins [Kato et al., FEBS Letters. 1991; 280: 325-328. This polyprotein is subsequently post-translationally cleaved to produce several viral proteins (Leinbach et al., 1994: 204: 163-169).

HCV의 9.5 킬로베이스 게놈의 조사결과 바이러스 핵산은 고비율로 돌연변이할 수 있는 것으로 증명되었다[Smith et al., Mol. Evol. 1997 45: 238-246]. 이러한 돌연변이 비율은 약 70%의 서열 동일성을 공유하는 HCV의 수개의 상이한 제노타입의 진화를 초래하였다[참조: Simmonds et al., J. Gen. Virol. 1994; 75: 1053-1061]. 중요한 것은 이러한 서열이 진화론적으로 관계가 매우 멀다는 것이다. 예컨대, 인간과 침팬지와 같은 영장류 사이의 유전학적 동일성은 약 98%이다. 또한, 개개 환자에서 HCV 감염은 RNA 수준에서 98%의 동일성을 가지는 수개의 상이한 진화성 유사종으로 구성되는 것이 증명되었다. 따라서, HCV 게놈은 초가변성이고 연속적으로 변화한다. HCV 게놈이 초가변성일지라도, 고도로 보존되는 3개 영역의 게놈이 있다. 이들 보존되는 서열은 5' 및 3' 비코딩 영역 뿐만 아니라 5' 말단의 가운데 단백질 코딩 영역에 존재하고 HCV RNA 복제 뿐만 아니라 HCV 폴리단백질의 번역에 중요한 것으로 생각된다. 따라서, 이러한 보존되는 HCV 게놈 영역을 표적화하는 치료제는 광범위한 HCV 제노타입에 대하여 현저한 효과를 나타낼 수 있다. 또한, HCV 게놈의 보존 영역에 특이적인 리보자임에 있어서 약물 내성은 일어나지 않을 것 같다. 대조적으로, 바이러스 프로테아제 또는 헬리카제와 같은 효소의 저해를 표적화하는 치료 양식은 이러한 바이러스 엔코딩된 효소에 대한 RNA가 HCV 게놈의 초가변성 부분에 위치하기 때문에 약물 내성 균주에 대하여 선택성을 가져올 것이다.Examination of the 9.5 kilobase genome of HCV demonstrated that viral nucleic acids can be mutated at high rates [Smith et al., Mol. Evol. 1997 45: 238-246. This mutation rate resulted in the evolution of several different genotypes of HCV that share about 70% sequence identity. Simmonds et al., J. Gen. Virol. 1994; 75: 1053-1061. Importantly, these sequences are very far from evolutionary. For example, the genetic identity between humans and primates such as chimpanzees is about 98%. In addition, HCV infection in individual patients has been shown to consist of several different evolutionary similar species with 98% identity at the RNA level. Thus, the HCV genome is hypervariable and changes continuously. Although the HCV genome is hypervariable, there are three regions of the genome that are highly conserved. These conserved sequences are present in the 5 'and 3' noncoding regions as well as in the middle protein coding region of the 5 'end and are believed to be important for HCV RNA replication as well as translation of HCV polyproteins. Thus, therapeutic agents that target these conserved HCV genomic regions may have significant effects on a wide range of HCV genotypes. In addition, drug resistance is unlikely to occur in ribozymes specific to the conserved region of the HCV genome. In contrast, therapeutic modalities that target inhibition of enzymes such as viral proteases or helicases will result in selectivity for drug resistant strains because the RNA for these viral encoded enzymes is located in the hypervariable portion of the HCV genome.

HCV에 처음 노출된 후에, 환자는 간 효소의 일시적인 상승을 겪으며, 이는 염증 과정이 발생하고 있음을 시사한다[참조: Alter et al., IN: Seef LB, Lewis JH, eds. Current Perspectives in Hepatology. New York: Plenum Medical Book Co; 1989: 83-89]. 상기 간 효소의 상승은 최초 노출 4주 이상 후에 일어날 것이며 2개월까지 지속할 수 있다[참조: Farci et al., New England Journal of Medicine. 1991: 325: 98-104]. 간 효소의 상승 전에, RT-PCR 분석을 사용한 환자 혈청에서 HCV RNA를 검출하는 것이 가능하다[참조: Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243]. 상기 질환의 이 단계는 급성기라고 하며, HCV 감염으로 인한 급성 바이러스성 간염을 가진 환자의 75%가 무증상이기 때문에 일반적으로 검출되지 않는다. 이들 환자의 나머지 25%가 황달 또는 간염의 기타 증상을 나타낸다.After first exposure to HCV, the patient undergoes a transient elevation of liver enzymes, suggesting that an inflammatory process is occurring. Alter et al., IN: Seef LB, Lewis JH, eds. Current Perspectives in Hepatology. New York: Plenum Medical Book Co; 1989: 83-89. The elevation of liver enzymes will occur at least 4 weeks after the initial exposure and can last up to 2 months. Farci et al., New England Journal of Medicine. 1991: 325: 98-104. Prior to elevation of liver enzymes, it is possible to detect HCV RNA in patient serum using RT-PCR analysis. Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243. This stage of the disease is called the acute phase and is generally not detected because 75% of patients with acute viral hepatitis due to HCV infection are asymptomatic. The remaining 25% of these patients show jaundice or other symptoms of hepatitis.

급성 HCV 감염은 양성 질환이지만, 급성 HCV 환자의 80%가 혈청 알라닌 아미노트랜스페라제(ALT) 수준의 지속적인 상승 및 순환 HCV RNA의 지속적인 존재로 나타나는 만성 간질환으로 진행한다[참조: Sherock, Lancet 1992; 339: 802]. 10 내지 20여년의 기간 동안 만성 HCV 감염의 자연적인 경과는 환자의 20 내지 50%에서 간경변으로 진행되며[참조: Davis et al., Infectious Agents and Disease 1993; 2: 150: 154], HCV 감염이 간세포성 암종으로 경과하는 것도 상당히 기록된 바 있다[참조: Liang et al., Hepatology. 1993; 18: 1326-1333; Tong et al., Western Journal of Medicine, 1994; Vol. 160, No. 2: 133-138]. 간경변 및/또는 간세포성 암종으로 진행될 가능성이 가장 큰 아집단을 결정하는 연구는 없었으며, 따라서, 모든 환자는 동등한 위험율의 진행성을 가진다.Acute HCV infection is a benign disease, but 80% of patients with acute HCV progress to chronic liver disease, which results in a sustained elevation of serum alanine aminotransferase (ALT) levels and the continued presence of circulating HCV RNA. Sherock, Lancet 1992 ; 339: 802. The natural course of chronic HCV infection over a period of 10 to 20 years progresses to cirrhosis in 20-50% of patients (see Davis et al., Infectious Agents and Disease 1993; 2: 150: 154], the progression of HCV infection to hepatocellular carcinoma has also been recorded significantly (Liang et al., Hepatology. 1993; 18: 1326-1333; Tong et al., Western Journal of Medicine, 1994; Vol. 160, No. 2: 133-138. There has been no study determining the subpopulations most likely to progress to cirrhosis and / or hepatocellular carcinoma, so all patients have an equal risk of progression.

중요한 것은 간세포성 암종으로 진단된 환자의 생존기간은 최초 진단으로부터 단지 0.9 내지 12.8개월이라는 점이다[참조: Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243]. 화학요법제를 사용한 간세포성 암종의 치료는 유효한 것으로 판명되지 않았고 단지 10%의 환자만이 종양의 광범위한 간 침윤에 기인한 수술로부터 이익이 있다[참조: Trinchet et al., Presse Medicine. 1994: 23: 831-833]. 원발성 간세포성 암종의 침윤성이 제공되는 경우, 수술에 대한 유일한 생존가능한 대체 치료는 간이식이다[참조: Pichlmayer et al., Hepatology. 1994: 20: 33S-40S].Importantly, the survival of patients diagnosed with hepatocellular carcinoma is only 0.9 to 12.8 months from the initial diagnosis. Takahashi et al., American Journal of Gastroenterology. 1993: 88: 2: 240-243. Treatment of hepatocellular carcinoma with chemotherapeutic agents has not been shown to be effective and only 10% of patients benefit from surgery due to extensive liver infiltration of the tumor. Trinchet et al., Presse Medicine. 1994: 23: 831-833. Given the invasiveness of primary hepatocellular carcinoma, the only viable alternative treatment for surgery is liver transplantation. Pichlmayer et al., Hepatology. 1994: 20: 33S-40S.

간경변으로 진행시, 만성 HCV 감염을 가진 환자는 최초의 원인과 무관하게 임상적인 간경변에 통상적인 임상적 특징을 나타낸다[참조: D'Amico et al., Digestive Diseases and Sciences. 1986; 31: 5: 468-475]. 이러한 임상적 특징은 출혈성 식도 정맥류, 복수, 황달, 및 뇌질환을 포함할 수 있다[참조: Zakim D, Boyer TD. Hepatology a textbook of liver disease. Second Edition Volume 1. 1990 W. B. Saunders Company. Philadelphia]. 간경변의 초기에, 환자는 간 조직 손상이 일어날지라도, 환자의 간은 여전히 혈류중의 대사물질을 해독할 수 있다는 대상적 의미로서 분류된다. 또한, 대상성 간 질환을 가진 대부분의 환자는 무증상이며, 증상을 나타낸 소수는 소화불량 및 허약함과 같은 경증만을 나타낸다. 간경변의 보다 후기에서는, 환자는 혈류중의 대사물질의 해독능이 감소하는 대상적 의미로서 분류되며 이 시기에서는 상기 임상적 특징이 존재한다.When progressing to cirrhosis, patients with chronic HCV infection exhibit clinical features common to clinical cirrhosis, regardless of the original cause. See D'Amico et al., Digestive Diseases and Sciences. 1986; 31: 5: 468-475. Such clinical features may include hemorrhagic esophageal varices, ascites, jaundice, and brain diseases. Zakim D, Boyer TD. Hepatology a textbook of liver disease. Second Edition Volume 1. 1990 W. B. Saunders Company. Philadelphia]. In the early stages of cirrhosis, the patient is classified as a target meaning that even if liver tissue damage occurs, the liver of the patient can still detoxify metabolites in the bloodstream. In addition, most patients with subject liver disease are asymptomatic, and a minority of symptoms only show mild symptoms such as indigestion and weakness. In later stages of cirrhosis, patients are classified as subjective meanings in which the detoxification of metabolites in the bloodstream is reduced, at which time the clinical characteristics are present.

1986년, 다미코(D'Amico) 등은 알코올성 및 바이러스성 간경변을 모두 가진 1155명의 환자에서 임상 증후 및 생존율을 기술하였다[D'Amico supra]. 1155명의 환자 중에서, 70%가 본 시험의 초기에 무증상이었으나, 435명(37%)이 대상성 질환을 가졌다. 나머지 720명(63%)의 환자는 대상부전 질환을 가졌고, 그 78%가 복수, 31%가 황달, 17%가 출혈의 병력을 나타냈고 16%는 뇌질환이었다. 간세포성 암종은 대상 질환을 가진 6명의 환자(.5%) 및 대상부전 질환을 가진 30명의 환자(2.6%)에서 관찰되었다.In 1986, D'Amico et al. Described clinical symptoms and survival in 1155 patients with both alcoholic and viral cirrhosis [D'Amico supra]. Of 1155 patients, 70% were asymptomatic at the beginning of this trial, but 435 (37%) had subject disease. The remaining 720 patients (63%) had dysplasia, 78% had ascites, 31% jaundice, 17% had bleeding, and 16% had brain disease. Hepatocellular carcinoma was observed in 6 patients (.5%) with subject disease and 30 patients (2.6%) with dysplasia.

6년의 기간에 걸쳐, 대상성 간경변을 가진 환자는 해마다 10%의 비율로 비대상성 질환의 임상적 특징을 나타내었다. 대부분의 경우, 복수는 최초로 발현되는 대상부전이었다. 또한, 초기에 대상 질환을 가진 것으로 나타난 59명의 환자에서 6년의 시험 기간이 끝났을 때 간세포성 암종이 나타났다.Over a six year period, patients with subject cirrhosis showed clinical characteristics of the non-target disease at a rate of 10% annually. In most cases, ascites was the first manifested dysfunction. In addition, hepatocellular carcinoma developed at the end of the six-year trial in 59 patients initially shown to have the subject disease.

생존과 관련하여, 다미코(D'Amico)의 연구는 본 시험에서 모든 환자에 대한 5년간의 생존율은 단지 40%이었음을 나타냈다. 초기에 대상 간경변을 가진 환자에 대한 6년간의 생존율은 54%이었던 반면, 초기에 대상부전 질환을 가진 것으로 나타난 환자에 대한 6년간의 생존율은 단지 21%였다. 알코올성 간경변을 가진 환자 및 바이러스성 간경변을 가진 환자 사이의 생존율에 유의한 차이는 없었다. 다미코(D'Amico)의 연구에서 환자 사망의 주된 원인은 49%에서 간부전; 22%에서 간세포성 암종; 및 13%에서 출혈이었다(D'Amico supra).In terms of survival, D'Amico's study indicated that the 5-year survival rate for all patients in this trial was only 40%. The 6-year survival rate for patients with initial cirrhosis was 54%, whereas the 6-year survival rate for patients with early disease was only 21%. There was no significant difference in survival between patients with alcoholic cirrhosis and those with viral cirrhosis. In D'Amico's study, the leading cause of patient death was liver failure in 49%; Hepatocellular carcinoma in 22%; And bleeding at 13% (D'Amico supra).

만성 C형 간염은 10 내지 20년의 기간에 걸쳐 간경변, 간부전 및/또는 간세포성 암종을 초래할 수 있는 바이러스(HCV)에 의해 매개된 서서히 진행하는 간의 염증성 질환이다. 미국에서, HCV 감염은 매년 미국에서 새로운 50,000명의 급성 간염 환자의 원인인 것으로 예측된다[참조: NIH Consensus Development Conference Statement on Management of Hepatitis C March 1997]. 미국에서 HCV의 유행은 1.8%로 예측되고 CDC는 만성적으로 감염된 미국인의 수를 약 4.5백만명으로 평가한다. CDC는 또한 해마다 10,000명의 사인은 만성 HCV 감염에 기인하는 것으로 평가한다.Chronic hepatitis C is a progressive liver inflammatory disease mediated by a virus (HCV) that can result in cirrhosis, liver failure and / or hepatocellular carcinoma over a period of 10 to 20 years. In the United States, HCV infection is predicted to be the cause of 50,000 new acute hepatitis patients in the United States each year (NIH Consensus Development Conference Statement on Management of Hepatitis C March 1997). The prevalence of HCV in the United States is estimated at 1.8%, and the CDC estimates that the number of chronically infected Americans is about 4.5 million. The CDC also estimates that 10,000 deaths each year are due to chronic HCV infection.

만성 HCV 감염의 치료에 인터페론(IFN-α)을 사용한 많은 대조 임상 시험 결과는 1주 3회 요법은 6개월의 치료가 끝날 때까지 약 50%의 환자(40 내지 70% 범위)에서 혈청 ALT 수치를 감소시킨 것으로 증명되었다[참조: Davis et al., New England Journal of Medicine 1989; 321: 1501-1506; Marcellin et al., Hepatology. 1991; 13: 393-397; Tong et al., Hepatology 1997; 26: 747-754; Tong et al., Hepatology 1997 26(6): 1640-1645]. 그러나, 인터페론 치료를 중지한 후에, 반응한 환자의 약 50%가 재발하였고, 그 결과 혈청 ALT 농도의 정상화로 평가되는 "영구성" 반응율은 약 20 내지 25%였다.Many control clinical trials using interferon (IFN-α) in the treatment of chronic HCV infection showed that serum ALT levels in approximately 50% of patients (range 40-70%) until the end of six months of treatment were given three times a week. Has been shown to be reduced (see Davis et al., New England Journal of Medicine 1989; 321: 1501-1506; Marcellin et al., Hepatology. 1991; 13: 393-397; Tong et al., Hepatology 1997; 26: 747-754; Tong et al., Hepatology 1997 26 (6): 1640-1645]. However, after discontinuing interferon treatment, about 50% of the patients who responded relapsed, with a result of about 20-25% of the “young” response assessed to normalize serum ALT concentrations.

최근 수년간, 분지된 DNA 또는 역전사 효소 중합효소 연쇄 반응(RT-PCR) 분석의 사용하여 HCV RNA의 직접적인 측정이 가능해졌다. 일반적으로, RT-PCR 방법은 보다 감조가 높고 임상적 경과를 보다 정확하게 평가하도록 한다[참조: Tong et al., supra]. 임상적 종말점으로서 HCV RNA 수치의 변화를 사용하여 6개월간의 타입 1 인터페론 요법을 조사한 연구 결과 35% 이하의 환자가 치료가 끝났을 때 HCV RNA가 소실되는 것으로 증명되었다[참조: Marcellin et al., supra]. 그러나, ALT 종말점에서와 같이, 환자의 약 50%가 치료 중지후 6개월에 재발한 결과, 영구의 바이러스학적 반응은 단지 12%에 불과하였다[참조: Marcellin et al., supra]. 48주 요법을 조사한 연구 결과 유지된 바이러스학적 반응은 25% 이하인 것으로 증명되었다(NIH 조사 성명서: 1997). 따라서, 타입 1 인터페론을 사용한 만성 HCV 감염의 치료에 대한 관리 표준은 현재 효능의 1차적 평가로서 HCV RNA의 농도 변화를 사용한 48주간의 치료법이다[참조: Hoofnagle et al., New England Journal of Medicine 1997; 336(5) 347-356].In recent years, direct measurement of HCV RNA has been possible using branched DNA or reverse transcriptase polymerase chain reaction (RT-PCR) analysis. In general, the RT-PCR method allows for higher sensitivity and more accurate assessment of clinical course (Tong et al., Supra). A study of 6 months of Type 1 interferon therapy using changes in HCV RNA levels as clinical endpoints demonstrated that up to 35% of patients lost HCV RNA at the end of treatment. Marcellin et al., Supra ]. However, as at the ALT endpoint, about 50% of patients recurred 6 months after discontinuation of treatment, resulting in only a permanent 12% viral response (Marlin et al., Supra). Studies of 48-week therapy have demonstrated that sustained virological response is less than 25% (NIH survey statement: 1997). Thus, the standard of care for the treatment of chronic HCV infection with type 1 interferon is the 48-week treatment with varying concentrations of HCV RNA as the primary assessment of current efficacy. Hoofnagle et al., New England Journal of Medicine 1997 ; 336 (5) 347-356.

타입 1 인터페론을 사용한 치료에 기인한 부작용은 4개의 일반적 범주로 분류될 수 있으며, 이는 1. 인플루엔자형 증상; 2. 신경정신증; 3. 실험실검사 이상; 및 4. 기타 혼합을 포함한다[참조: Dusheiko et al., Journal of Viral Hepatitis. 1994: 1: 3-5]. 인플루엔자형 증상의 예로서 피로, 열, 근융통, 권태감, 식욕 상실, 빈맥, 경직, 두통 및 관절통을 포함한다. 인플루엔자형 증상은 일반적으로 일시적이며 투여 첫 4주 후에 감소되는 경항이 있다[참조: Dusheiko et al., supra]. 신경정신증적 부작용은 과민성, 무감동, 기분 변화, 불면증, 인식 변화 및 우울증을 포함한다. 이러한 신경정신증적 부작용중 가장 중요한 것은 우울증이며, 우울증의 병력이 있는 환자는 타입 1 인터페론을 투여받으면 안된다. 실험실검사 이상은 과립구, 혈소판을 포함한 골수 세포의 감소 및 적혈구수의 감소를 포함한다. 혈구수에서 이러한 변화는 어떠한 현저한 임상적 후유증을 거의 일으키지 못한다[참조: Dusheiko et al., supra]. 또한, 트리글리세라이드 농도의 증가 및 혈청 알라닌 및 아스파르테이트 아미노트랜스페라제 농도의 상승이 관찰되었다. 마지막으로, 갑상선 이상이 보고되었다. 이러한 갑상선 이상은 일반적으로 인터페론 요법의 중지후에 역전되며 치료중에 적당한 약물투여로 조절될 수 있다. 기타 혼합적인 부작용은 오심, 설사, 복통 및 요통, 소양증, 탈모, 및 콧물을 포함한다. 일반적으로 대부분의 부작용은 치료 4주 내지 8주 후에 감소된다[참조: Dusheiko et al., supra].Side effects resulting from treatment with type 1 interferon can be classified into four general categories, including 1. influenza-like symptoms; 2. neuropsychiatric; 3. abnormal laboratory tests; And 4. other blends. Dusheiko et al., Journal of Viral Hepatitis. 1994: 1: 3-5]. Examples of influenza-like symptoms include fatigue, fever, myalgia, malaise, loss of appetite, tachycardia, stiffness, headache and joint pain. Influenza-like symptoms are usually transient and tend to decrease after the first four weeks of administration (Dusheiko et al., Supra). Neuropsychiatric side effects include irritability, numbness, mood changes, insomnia, cognitive changes, and depression. The most important of these neuropsychiatric side effects is depression, and patients with a history of depression should not receive Type 1 interferon. Laboratory abnormalities include the reduction of bone marrow cells, including granulocytes, platelets, and a decrease in the number of red blood cells. These changes in blood cell count rarely cause any significant clinical sequelae (Dusheiko et al., Supra). In addition, an increase in triglyceride concentration and an increase in serum alanine and aspartate aminotransferase concentrations were observed. Finally, thyroid abnormalities have been reported. Such thyroid abnormalities are generally reversed after discontinuation of interferon therapy and can be controlled with appropriate drug administration during treatment. Other mixed side effects include nausea, diarrhea, abdominal pain and back pain, pruritis, hair loss, and runny nose. In general, most side effects are reduced after 4 to 8 weeks of treatment (Dusheiko et al., Supra).

웰치(Welch) 등[참조: Gene Therapy 1996 3(11): 994-1001]은 C형 간염 바이러스를 표적으로 하는 2개의 벡터 발현된 헤어핀 리보자임에 있어서 시험관내 및 생체내 연구를 기술한다.Welch et al., Gene Therapy 1996 3 (11): 994-1001, describe in vitro and in vivo studies in two vector expressed hairpin ribozymes targeting hepatitis C virus.

사카모토(Sakamoto) 등[참조: J. Clinical Investigation 1996 98(12): 2720-2728]은 특정한 벡터 발현된 해머헤드 리보자임에 의한 C형 간염 바이러스 RNA의 세포내 절단 및 바이러스 단백질 번역의 저해를 기술한다.Sakamoto et al. (J. Clinical Investigation 1996 98 (12): 2720-2728) describe the inhibition of intracellular cleavage and viral protein translation of hepatitis C virus RNA by specific vector-expressed hammerhead ribozymes. do.

리이베(Lieber) 등[참조: J. Virology 1996 70(12): 8782-8791]은 아데노바이러스 매개의 특정 해머헤드 리보자임의 발현에 의한 감염된 인간 간세포에서 C형 간염 바이러스 RNA의 제거를 기술한다.Lieber et al. (J. Virology 1996 70 (12): 8782-8791) describe the removal of hepatitis C virus RNA from infected human hepatocytes by expression of adenovirus mediated specific hammerhead ribozymes. .

오카와(Ohkawa) 등[참조: 1997, J. Hepatology, 27; 78-84]은 특정한 시험관내 전사된 해머헤드 리보자임을 사용한 HCV RNA의 시험관내 절단 및 바이러스 단백질 번역의 저해를 기술한다.Ohkawa et al., 1997, J. Hepatology, 27; 78-84 describes inhibition of in vitro cleavage and viral protein translation of HCV RNA using specific in vitro transcribed hammerhead ribozymes.

바아버(Barber) 등[참조: 국제 PCT 공개 제 WO97/32018호]은 특정한 항-C형 간염 바이러스 헤어핀 리보자임을 발현하기 위한 아데노바이러스 벡터의 용도를 기술한다.Barber et al., International PCT Publication No. WO97 / 32018, describe the use of adenovirus vectors to express certain anti-hepatitis C virus hairpin ribozymes.

케이(Kay) 등[참조: 국제 PCT 공개 제 WO96/18419호]은 항-HCV 해머헤드 리보자임을 발현하기 위한 특정한 재조합 아데노바이러스 벡터를 기술한다.Kay et al., International PCT Publication No. WO96 / 18419, describe certain recombinant adenovirus vectors for expressing anti-HCV hammerhead ribozymes.

야마다(Yamada) 등[참조: 일본 특허 출원 제 JP07231784호]은 HCV를 표적으로 하는 특정 폴리-(L)-리신 콘쥬게이션된 해머헤드 리보자임을 기술한다.Yamada et al. (Japanese Patent Application No. JP07231784) describes a specific poly- (L) -lysine conjugated hammerhead riboza that targets HCV.

드래퍼(Draper)[참조: 미국 특허 제 5,610,054호]는 HCV의 복제를 저해할 수 있는 효소적 핵산 분자를 기술한다.Draper (US Pat. No. 5,610,054) describes enzymatic nucleic acid molecules that can inhibit the replication of HCV.

알트(Alt) 등[참조: Hepatology 1995 22(3): 707-717]은 특정한 안티센스 포스포로티오에이트 올리고데옥시누클레오티드에 의한 C형 간염 바이러스 유전자 발현의 특이적 저해를 기술한다.Alt et al., Hepatology 1995 22 (3): 707-717, describe specific inhibition of hepatitis C virus gene expression by specific antisense phosphorothioate oligodeoxynucleotides.

발명의 개요Summary of the Invention

본 발명은 C형 간염 바이러스(HCV)의 RNA종을 절단하도록 되고/거나 HCV에 의해 엔코딩되는 리보자임 또는 효소적 핵산 분자에 관한 것이다. 특히, 출원인은 HCV RNA를 특이적으로 절단할 수 있는 리보자임의 선택 및 기능을 기술한다. 이러한 리보자임은 HCV 감염과 관련된 질환을 치료하기 위하여 사용될 수 있다.The present invention relates to ribozymes or enzymatic nucleic acid molecules that are adapted to cleave RNA species of hepatitis C virus (HCV) and / or encoded by HCV. In particular, Applicants describe the selection and function of ribozymes capable of specifically cleaving HCV RNA. Such ribozymes can be used to treat diseases associated with HCV infection.

HCV 게놈의 높은 서열 가변성 때문에, 광범위한 치료적 응용을 위한 리보자임의 선택은 HCV 게놈의 보존 영역과 관련될 것이다. 상세하게는, 본 발명은 HCV 게놈의 보존 영역에서 절단시키는 해머헤드 리보자임을 기술한다. HCV 게놈의 보존 영역(5'-비코딩 영역(NCR), 코아 단백질 코딩 영역의 5'-말단, 및 3'-NCR)으로부터 유래된 30개의 해머헤드 리보자임의 목록은 표 Ⅳ에 제시된다. 일반적으로, 본 출원인은 HCV 게놈의 5' 말단에 위치한 부위를 절단시키는 효소적 핵산 분자가 번역을 차단하는 반면, 상기 게놈의 3' 말단에 위치한 부위를 절단시키는 리보자임은 RNA 복제를 차단함을 발견하였다. 약 50개 HCV 분리물이 확인되었고 제노타입 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a, 및 6a로부터 이러한 분리물의 서열 정렬이 수행되었다. 본 출원인은 이러한 정렬을 사용하여 제노타입간에 고도로 보존된 영역내의 30개의 해머헤드 리보자임 부위를 확인하였다. 23개의 리보자임 부위는 보존 영역내의 최대의 상동성 영역에서 확인되었다. 따라서, 1개의 리보자임이 HCV의 모든 상이한 분리물을 절단하도록 예정될 수 있다. 본 출원인에 의하면, 다양한HCV 분리물의 보존 영역에 대항하도록 예정된 리보자임은 다양한 환자 집단에서 HCV 복제의 효율적 저해를 가능케 할 것이고 HCV 게놈의 비보존 영역에서 돌연변이에 기인하여 진화한 HCV 유사종에 대한 리보자임의 유효성을 보장할 수 있다.Because of the high sequence variability of the HCV genome, the selection of ribozymes for a wide range of therapeutic applications will be related to the conserved region of the HCV genome. Specifically, the present invention describes hammerhead ribozymes that cleave in the conserved regions of the HCV genome. A list of 30 hammerhead ribozymes derived from the conserved region of the HCV genome (5'-noncoding region (NCR), 5'-end of core protein coding region, and 3'-NCR) is shown in Table IV. In general, Applicants note that enzymatic nucleic acid molecules that cleave a site located at the 5 'end of the HCV genome block translation, whereas ribozymes that cleave a site located at the 3' end of the genome block RNA replication. Found. About 50 HCV isolates were identified and sequence alignments of these isolates from genotypes 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a, and 6a were performed. Applicants used this alignment to identify 30 hammerhead ribozyme sites in highly conserved regions between genotypes. 23 ribozyme sites were identified in the largest homology region in the conserved region. Thus, one ribozyme can be scheduled to cleave all different isolates of HCV. According to Applicants, ribozymes destined to confront the conserved regions of various HCV isolates will enable efficient inhibition of HCV replication in a variety of patient populations and will be ribosomes for HCV-like species that have evolved due to mutations in non-conserved regions of the HCV genome. The effectiveness of the role can be guaranteed.

"저해"는 HCV의 활성 또는 HCV 게놈에 의해 엔코딩된 RNA의 수준이 핵산의 부재하에서 관찰되는 것 미만으로 감소되고, 특히 리보자임을 사용한 저해는 mRNA의 동일한 부위와 결합할 수 있으나 상기 RNA를 절단시킬 수 없는 비활성 RNA 분자의 존재하에서 관찰된 수준 미만인 것을 의미한다."Inhibition" is that the activity of HCV or the level of RNA encoded by the HCV genome is reduced below that observed in the absence of nucleic acid, in particular inhibition using ribozymes may bind to the same site of mRNA but cleave the RNA It is meant to be below the level observed in the presence of an inactive RNA molecule that cannot be made.

"효소적 핵산"은 다른 핵산 분자의 부위 특이적 절단 및/또는 연결, 펩티드 및 아미드 결합의 절단, 및 트랜스-스플라이싱을 포함하지만 이에 한정되지 않는 촉매화 반응이 가능한 핵산 분자를 의미한다. 엔도누클레아제 활성을 가진 이러한 분자는 지정된 유전자 표적에 대한 기질 결합 영역에서 상보성을 가질 수 있고, 상기 표적에서 RNA 및 DNA를 특이적을 절단시키는 효소 활성을 가질 수도 있다. 즉, 엔도누클레아제 활성을 가진 핵산 분자는 분자내 또는 분자간에 RNA 또는 DNA를 절단시킬 수 있으므로 표적 RNA 또는 DNA 분자를 불활성화할 수 있다. 이러한 상보성은 효소적 RNA 분자를 표적 RNA 또는 DNA와 충분히 하이브리드화시켜 절단이 일어나도록 하는 기능을 한다. 100% 상보성이 바람직하지만, 50 내지 75%의 상보성도 본 발명에서 유용할 수 있다. 핵산은 염기, 당, 및/또는 인산기에서 변형될 수 있다. 효소적 핵산이라는 용어는 리보자임, 촉매적 RNA, 효소적 RNA, 촉매적 DNA, 촉매적 올리고누클레오티드, 누클레오자임, DNA자임, RNA 효소, 엔도리보누클레아제, 엔도누클레아제, 미니자임, 리드자임, 올리고자임 또는 DNA 효소와 같은 어구와 상호교환적으로 사용된다. 본원에서 기술된 특이적 효소적 핵산 분자는 본 발명에서 제한되지 않으며, 당업자는 본 발명의 효소적 핵산 분자가 하나 이상의 표적 핵산 영역에 상보적인 특이적 기질 결합 부위를 가지며, 분자에 핵산 절단 활성을 부여하는 기질 결합 부위 내 또는 주변의 누클레오티드 서열을 가지는 것이 중요하다는 것을 인지할 것이다."Enzymatic nucleic acid" means a nucleic acid molecule capable of a catalytic reaction, including but not limited to site specific cleavage and / or ligation of other nucleic acid molecules, cleavage of peptide and amide bonds, and trans-splicing. Such molecules with endonuclease activity may have complementarity at the substrate binding region for designated gene targets and may have enzymatic activity that specifically cleaves RNA and DNA at the target. That is, nucleic acid molecules with endonuclease activity can cleave RNA or DNA within or between molecules, thereby inactivating the target RNA or DNA molecule. This complementarity functions to sufficiently hybridize the enzymatic RNA molecule with the target RNA or DNA so that cleavage occurs. 100% complementarity is preferred, but between 50 and 75% complementarity may also be useful in the present invention. Nucleic acids can be modified at base, sugar, and / or phosphate groups. The term enzymatic nucleic acid refers to ribozyme, catalytic RNA, enzymatic RNA, catalytic DNA, catalytic oligonucleotide, nucleozyme, DNAzyme, RNA enzyme, endoribonuclease, endonuclease, minizyme, It is used interchangeably with phrases such as reedzyme, oligozyme or DNA enzyme. Specific enzymatic nucleic acid molecules described herein are not limited in the present invention and those skilled in the art will appreciate that the enzymatic nucleic acid molecules of the present invention have specific substrate binding sites that are complementary to one or more target nucleic acid regions, and that the nucleic acid cleavage activity may be It will be appreciated that it is important to have a nucleotide sequence in or around the conferring substrate binding site.

"효소적 부분" 또는 "촉매적 도메인"은 핵산 기질의 절단에 필수적인 리보자임의 부분/영역을 의미한다(예컨대, 도 1 참조).By “enzymatic moiety” or “catalytic domain” is meant a portion / region of ribozyme essential for cleavage of a nucleic acid substrate (see, eg, FIG. 1).

"기질 결합 아암(arm)" 또는 "기질 결합 도메인"은 기질의 부분에 상보적인(즉, 이와 염기쌍을 이룰 수 있는) 리보자임의 부분/영역을 의미한다. 일반적으로, 이러한 상보성은 100%이지만, 필요에 따라 보다 적을 수 있다. 예컨대, 14개 중 10개의 염기가 염기쌍을 이룰 수 있다. 이러한 아암(arm)은 일반적으로 도 1 및 3에 도시된다. 즉, 이러한 아암(arm)은 상보적 염기쌍 상호작용을 통하여 리보자임 및 표적 RNA를 짝짓도록 한 리보자임내의 서열을 함유한다. 본 발명의 리보자임은 인접 또는 비인접하고 다양한 길이일 수 있는 결합 아암(arm)을 가질 수 있다. 결합 아암(arm)의 길이는 바람직하게는 4개 누클레오티드 이상이다; 특히 12 내지 100개 누클레오티드; 보다 특별히 14 내지 24개 누클레오티드 길이이다. 2개의 결합 아암(arm)이 선택된 경우, 결합 아암(arm)의 길이가 대칭(즉, 각각의 결합 아암(arm)의 길이가 동일하다; 예컨대 5개 및 5개 누클레오티드, 6개 및 6개 누클레오티드 또는 7개 및 7개 누클레오티드 길이) 또는 비대칭(즉, 결합 아암(arm)의 길이가 상이하다; 예컨대, 6개 및 3개 누클레오티드; 3개 및 6개 누클레오티드 길이; 4개 및 5개 누클레오티드 길이; 4개 및 6개 누클레오티드 길이; 4개 및 7개 누클레오티드 길이; 등)이도록 설계된다."Substrate binding arm" or "substrate binding domain" refers to a portion / region of a ribozyme that is complementary to (ie, base-paired with) a portion of a substrate. In general, this complementarity is 100%, but may be less if desired. For example, 10 out of 14 bases can be base paired. Such arms are generally shown in FIGS. 1 and 3. In other words, these arms contain sequences within the ribozymes that allow for ribozyme and target RNA pairing through complementary base pair interactions. The ribozymes of the present invention may have binding arms that are adjacent or nonadjacent and may be of various lengths. The length of the binding arm is preferably at least 4 nucleotides; In particular 12 to 100 nucleotides; More particularly 14 to 24 nucleotides in length. If two binding arms are selected, the length of the binding arms is symmetrical (ie, the length of each binding arm is the same; for example, five and five nucleotides, six and six nucleotides). Or 7 and 7 nucleotides in length) or asymmetric (ie, the length of the binding arm is different; for example, 6 and 3 nucleotides; 3 and 6 nucleotides in length; 4 and 5 nucleotides in length); 4 and 6 nucleotides in length; 4 and 7 nucleotides in length;

본원에서 발명의 가장 바람직한 구현예중 하나에서, 효소적 핵산 분자는 해머헤드 또는 헤어핀 모티프로 형성되지만, 간염 d 바이러스, Ⅰ군 인트론, Ⅱ군 인트론 또는 RN아제P RNA(RNA 가이드 서열과 관련) 또는 뉴로스포라(Neyrospora) VS RNA의 모티프로 형성될 수도 있다. 이러한 해머헤드 모티프의 예는 문헌[Dreyfus, supra, Rossi et al., 1992, AIDS Research and Human Retroviruses 8, 183]에 기재되어 있고; 헤어핀 모티프의 예는 문헌[Hampel et al., EP036257, Hempel and Trittz, 1989 Biochemistry 28, 4929, Feldstein et al., 1989, Gene 82, 53, Haseloff and Gerlach, 1989, Gene, 82, 43, and Hempel et al., 1990 Nucleic Scids Res. 18, 299]에 기재되어 있으며; 간염 d 바이러스 모티프는 문헌[Perrotta and Been, 1992 Biochemistry 31, 16]에 기재되어 있고; RN아제P 모티프의 예는 문헌[Guerrier-Takeda et al., 1983 Cell 35, 849; Foster and Altman, 1990, Science 249, 783; Li and Altman, 1996, Nucleic Acids Res. 24, 835]에 기재되어 있으며; 뉴로스포라(Neurospora) VS RNA 리보자임 모티프의 예는 Collins의 문헌[Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemistry 32, 2795-2799; Guo and Collins, 1995, EMBO. J. 14, 363]에 기재되어 있고; Ⅱ군 인트론의 예는 문헌[Griffin et al., 1995, Chem. Biol. 2, 761; Michels and Pyle, 1995, Biochemistry 34, 2965; Pyle et al., International PCT Publication No. WO96/22689]에 기재되어 있으며; Ⅰ군 인트론의 예는 문헌[Cech et al., U.S. Patent 4,987,071]에 기재되어 있고; DNA자임 모티프의 예는 문헌[Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, PNAS 94, 4262]에 기재되어 있다. 이러한 특이적 모티프는 본 발명에 한정되지 않으며 당업자는 본 발명의 효소적 핵산 분자가 하나 이상의 표적 유전자 RNA 영역에 상보적인 특이적 기질 결합 부위를 가지며, 상기 분자에 RNA 절단 활성을 부여하는 기질 결합 부위 내 또는 주변의 누클레오티드 서열을 가지는 것이 중요함을 인지할 것이다.In one of the most preferred embodiments of the invention herein, the enzymatic nucleic acid molecule is formed with a hammerhead or hairpin motif, but with hepatitis d virus, group I introns, group II introns or RNase P RNA (associated with RNA guide sequences) or neurons. It may also be formed with the motif of Nerosrospora VS RNA. Examples of such hammerhead motifs are described in Dreyfus, supra, Rossi et al., 1992, AIDS Research and Human Retroviruses 8, 183; Examples of hairpin motifs are described in Hamel et al., EP036257, Hempel and Trittz, 1989 Biochemistry 28, 4929, Feldstein et al., 1989, Gene 82, 53, Haseloff and Gerlach, 1989, Gene, 82, 43, and Hempel et al., 1990 Nucleic Scids Res. 18, 299; Hepatitis d virus motifs are described in Perrotta and Been, 1992 Biochemistry 31, 16; Examples of RNase P motifs are described in Guerrier-Takeda et al., 1983 Cell 35, 849; Foster and Altman, 1990, Science 249, 783; Li and Altman, 1996, Nucleic Acids Res. 24, 835; Examples of Neurospora VS RNA ribozyme motifs are described in Collins, Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991 Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993 Biochemistry 32, 2795-2799; Guo and Collins, 1995, EMBO. J. 14, 363; Examples of group II introns are described in Griffin et al., 1995, Chem. Biol. 2, 761; Michels and Pyle, 1995, Biochemistry 34, 2965; Pyle et al., International PCT Publication No. WO96 / 22689; Examples of group I introns are described in Cech et al., U.S. Patent 4,987,071; Examples of DNAzyme motifs are described in Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, PNAS 94, 4262. Such specific motifs are not limited to the present invention and those skilled in the art will recognize that the enzymatic nucleic acid molecule of the present invention has a specific substrate binding site complementary to one or more target gene RNA regions, and that the substrate binding site confers RNA cleavage activity to the molecule. It will be appreciated that having a nucleotide sequence within or around it is important.

HCV에 대한 "동등한" RNA는 인간, 설치류, 영장류, 토끼 및 돼지를 포함한 다양한 동물에서 HCV 감염과 관련된 천연의 RNA 분자를 포함하는 것을 의미한다. 동등한 RNA 서열은 코딩 영역 뿐만 아니라 5'-비번역 영역, 3'-비번역 영역, 인트론, 인트론-엑손 접합부 등도 포함한다.By "equivalent" RNA for HCV is meant to include native RNA molecules associated with HCV infection in various animals including humans, rodents, primates, rabbits and pigs. Equivalent RNA sequences include coding regions as well as 5'-untranslated regions, 3'-untranslated regions, introns, intron-exon junctions, and the like.

"상보성"은 전형적인 왓슨-크릭(Watson-Crick) 또는 기타 비전형적인 유형의 염기쌍 상호작용(예컨대, Hoogsteen형)에 의해 다른 DNA 서열과 수소 결합을 형성할 수 있는 핵산을 의미한다."Complementarity" refers to a nucleic acid capable of forming hydrogen bonds with other DNA sequences by typical Watson-Crick or other atypical types of base pair interactions (eg, Hoogsteen type).

한 바람직한 구현예에서, 본 발명은 목적하는 표적의 RNA에 고도의 특이성을 나타내는 일종의 효소적 절단제를 제조하는 방법을 제공한다. 효소적 핵산 분자는 바람직하게는 HCV 단백질을 엔코딩하는 표적 mRNA의 고도의 보존 영역을 표적으로 하여 1개 또는 수개의 효소적 핵산으로 질병의 특이적 치료가 제공될 수 있다. 이러한 효소적 핵산 분자는 필요에 따라 특이적 세포에 외인성으로 전달될 수 있다. 대안적으로, 리보자임은 특이적 세포에 전달되는 DNA/RNA 벡터로부터 발현될 수 있다.In one preferred embodiment, the present invention provides a method for preparing a kind of enzymatic cleavage agent that exhibits high specificity for RNA of a desired target. Enzymatic nucleic acid molecules may be provided for the specific treatment of a disease with one or several enzymatic nucleic acids, preferably targeting a highly conserved region of the target mRNA encoding the HCV protein. Such enzymatic nucleic acid molecules can be exogenously delivered to specific cells as needed. Alternatively, ribozymes can be expressed from DNA / RNA vectors delivered to specific cells.

이러한 리보자임은 상기 질환, 및 세포 또는 조직에서 HCV 활성의 수준과 관련된 기타 질환의 예방에 유용하다.Such ribozymes are useful for the prevention of such diseases and other diseases associated with the level of HCV activity in cells or tissues.

"관련"이라 함은 HCV RNA의 저해 및 이렇게 이루어진 각각의 바이러스 활성 수준의 감소가 질병의 증상을 어느 정도 완화할 것임을 의미한다.By “relevant” it is meant that inhibition of HCV RNA and a reduction in the respective viral activity levels thus achieved will somewhat relieve the symptoms of the disease.

바람직한 구현예에서, 리보자임은 표 Ⅳ 내지 Ⅸ의 표적 서열과 상보적인 결합 아암(arm)을 가진다. 이러한 리보자임의 예는 또한 표 Ⅳ 내지 Ⅸ에 제시된다. 이러한 리보자임의 예는 이들 표에 정의된 서열을 필수적으로 포함한다. 이러한 절단을 방해하지 않은 기타 서열이 존재할 수 있다.In a preferred embodiment, the ribozyme has a binding arm that is complementary to the target sequences of Tables IV-VII. Examples of such ribozymes are also shown in Tables IV-VII. Examples of such ribozymes essentially include the sequences defined in these tables. Other sequences may be present that do not interfere with such cleavage.

"주성분으로 포함한다"는 것은 활성 리보자임이 예시된 것과 동등한 효소 중심 또는 코아를 함유하고, 결합 아암(arm)이 mRNA와 결합하여 표적 부위에서 절단이 일어나도록 할 수 있다는 것을 의미한다."Contains principally" means that the active ribozyme contains an enzyme center or core equivalent to that exemplified, and that the binding arm can bind mRNA and cause cleavage at the target site.

따라서, 제 1의 측면에서, 본 발명은 유전자 발현 및/또는 바이러스 복제를 저해하는 리보자임을 특징으로 한다. 이러한 화학적 또는 효소적으로 합성된 RNA 분자는 표적 mRNA의 접근가능한 영역과 결합하는 기질 결합 도메인을 함유한다. 또한, RNA 분자는 RNA의 절단을 촉매하는 도메인을 함유한다. 바람직하게는, RNA 분자는 해머헤드 또는 헤어핀 모티프의 리보자임이다. 결합시에, 리보자임은 표적 mRNA를 절단시켜, 번역 및 단백질 축적을 방지한다. 표적 유전자 발현의 부재시에, HCV 유전자 발현 및/또는 복제는 저해된다.Thus, in a first aspect, the invention is characterized in that it is a riboza that inhibits gene expression and / or viral replication. Such chemically or enzymatically synthesized RNA molecules contain a substrate binding domain that binds to an accessible region of the target mRNA. RNA molecules also contain domains that catalyze the cleavage of RNA. Preferably, the RNA molecule is a ribozyme of a hammerhead or hairpin motif. Upon binding, ribozyme cleaves the target mRNA, preventing translation and protein accumulation. In the absence of target gene expression, HCV gene expression and / or replication is inhibited.

한 바람직한 구현예에서, 리보자임은 표적 세포에 직접 첨가되거나, 양이온성 지질과 복합체를 형성하고, 리포좀내에 봉입되거나, 기타 다른 방법으로 표적 세포에 전달될 수 있다. 핵산 분자 또는 핵산 복합체는 생체고분자에 혼입 또는 혼입되지 않고 주사, 주입 펌프 또는 스텐트를 통하여 관련 조직으로 국소적으로 투여될 수 있다. 다른 바람직한 구현예에서, 리보자임은 적당한 리포좀 비히클내에서 HCV 활성의 부위(예컨대, 간세포)에 투여된다.In one preferred embodiment, the ribozyme can be added directly to the target cell, complexed with cationic lipids, enclosed in liposomes, or delivered to the target cell by other means. Nucleic acid molecules or nucleic acid complexes may be topically administered to related tissues via injection, infusion pumps or stents, without incorporation into or incorporation into the biopolymer. In another preferred embodiment, the ribozyme is administered to a site of HCV activity (eg hepatocytes) in a suitable liposome vehicle.

본 발명의 다른 측면에서, 표적 분자를 절단하고 HCV 활성을 저해하는 리보자임은 DNA 또는 RNA 벡터에 삽입된 전사 단위로부터 발현된다. 재조합 벡터는 바람직하게는, DNA 플라스미드 또는 바이러스 벡터이다. 리보자임을 발현하는 바이러스 벡터는 아데노관련 바이러스, 레트로바이러스, 아데노바이러스, 또는 알파바이러스를 기재로 하여 작제될 수 있으나, 이에 한정되지 않는다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 전달되어 표적 세포에 잔존한다. 대안적으로, 바이러스 벡터는 리보자임의 일시적 발현을 위해 사용될 수 있다. 이러한 벡터는 필요에 따라 반복적으로 투여될 수 있다. 일단 발현되면, 리보자임은 표적 mRNA를 절단시킨다. 리보자임 발현 벡터의 전달은, 예컨대 정맥내 투여 또는 근육내 투여, 환자로부터 외식된 표적 세포로 투여후 환자에 재도입하거나 목적하는 표적 세포로 도입하기 위하여 허용되는 기타 수단에 의해 에 의해 전신적으로 이루어질 수 있다[참조: Culture and Stinchcomb, 1996, TIG., 12, 510]. 본 발명의 다른 측면에서, 표적 분자를 절단시키고 바이러스 복제를 억제하는 리보자임은 DNA, RNA, 또는 바이러스 벡터에 삽입된 전사 단위로부터 발현된다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 국소적으로 전달되어 평활근 세포에 일시적으로 잔존한다. 그러나, RNA 발현을 지시하는 다른 포유동물 세포 벡터가 본 목적으로 사용될 수 있다.In another aspect of the invention, ribozymes that cleave the target molecule and inhibit HCV activity are expressed from transcriptional units inserted into a DNA or RNA vector. The recombinant vector is preferably a DNA plasmid or viral vector. Viral vectors expressing ribozymes may be constructed based on adeno-associated viruses, retroviruses, adenoviruses, or alphaviruses, but are not limited thereto. Preferably, recombinant vectors capable of expressing ribozymes are delivered as described above and remain in the target cell. Alternatively, viral vectors can be used for transient expression of ribozymes. Such vectors may be administered repeatedly as needed. Once expressed, ribozyme cleaves the target mRNA. Delivery of ribozyme expression vectors may be systemic, for example by intravenous or intramuscular administration, by other means acceptable for reintroduction to the patient or introduction into the target cell of interest after administration from the patient to the explanted target cell. [Cultural and Stinchcomb, 1996, TIG., 12, 510]. In another aspect of the invention, ribozymes that cleave the target molecule and inhibit viral replication are expressed from transcriptional units inserted into DNA, RNA, or viral vectors. Preferably, the recombinant vector capable of expressing ribozymes is delivered locally as described above and temporarily remains in smooth muscle cells. However, other mammalian cell vectors that direct RNA expression can be used for this purpose.

"환자"는 외식된 세포의 공여자 또는 피이식자 또는 세포 그자체인 유기체를 의미한다. "환자"는 효소적 핵산 분자가 투여될 수 있는 유기체를 지칭하기도 한다. 바람직하게는, 환자는 포유동물 또는 포유동물 세포이다. 보다 바람직하게는, 환자는 인간 또는 인간 세포이다."Patient" means an organism that is a donor or transplant of explanted cells or the cell itself. "Patient" also refers to an organism to which an enzymatic nucleic acid molecule can be administered. Preferably, the patient is a mammal or mammalian cell. More preferably, the patient is a human or human cell.

"벡터"는 목적하는 핵산을 전달시키기 위하여 사용되는 핵산 및/또는 바이러스를 기초로 한 기술을 의미한다.By "vector" is meant a technique based on a nucleic acid and / or virus used to deliver a nucleic acid of interest.

이러한 리보자임은 개별적으로, 또는 다른 약물과 병용 또는 함께 상기 질환을 치료하기 위해 사용될 수 있다. 예컨대, HCV 수준과 관련된 질환을 치료하기 위하여, 당업자에게 자면한 바와 같이, 환자를 치료하거나, 다른 적당한 세포를 치료할수 있다.Such ribozymes can be used individually or in combination with other drugs or together to treat the disease. For example, to treat a disease associated with HCV levels, the patient may be treated or other suitable cells may be treated, as would be apparent to one skilled in the art.

본 발명의 다른 특징 및 장점은 바람직한 구현예의 하기 설명, 및 청구범위로부터 자명할 것이다.Other features and advantages of the invention will be apparent from the following description of the preferred embodiments, and from the claims.

바람직한 구현예의 설명Description of the Preferred Embodiments

먼저, 도면을 간단하게 설명한다.First, the drawings are briefly described.

도면:drawing:

도 1은 몇가지 다른 종류의 효소적 핵산 분자에 대한 2차 구조 모델을 도시한다. 화살표는 절단 부위를 나타내고, 표적 서열을 나타낸다. 점으로 처리된 선은 3차 상호작용을 나타내고, 염기쌍 상호작용을 나타냄을 의미한다. Ⅰ군 인트론: P1 내지 P9은 다양한 스템-루프 구조를 나타낸다[참조: Cech et al., 1994, Nature Struc. Bio., 1, 273]. RN아제P(M1RNA): EGS는 외부 가이드 서열을 나타낸다[Forster et al., 1990, Science, 249, 783; Pace et al., 1990, J. Biol. Chem., 265, 3587]. Ⅱ군 인트론: 5'SS는 5'스플라이스 부위를 의미한다; 3'SS는 3'-스플라이스 부위를 의미한다; IBS는 인트론 결합 부위를 의미한다; EBS는 엑손 결합 부위를 의미한다[참조: Pyle et al., 1994, Biochemistry, 33, 2716]. VS RNA: Ⅰ내지 Ⅵ은 6개 스템-루프 구조를 나타내는 것을 의미한다; 차단된 영역은 3차 상호작용을 나태내는 것을 의미한다[참조: Collins, International PCT Publication No. WO 96/19577]. HDV 리보자임: Ⅰ내지 Ⅳ는 4개의 스템-루프 구조를 나타내는 것을 의미한다[참조: Been et al., US Patent No. 5,625,047] 해머헤드 리보자임: Ⅰ내지 Ⅲ은 3개의 스템-루프 구조를 나타내는 것을 의미한다; 스템 Ⅰ내지 Ⅲ은 임의의 길이일 수 있으며 대칭 또는 비대칭일 수 있다[참조: Usman et al., 1996, Curr. Op. Struct. Bio., 1, 527]. 헤어핀 리보자임: 헬릭스 1, 4 및 5는 임의의 길이일 수 있다; 헬릭스 2는 3 내지 8의 염기쌍 길이이다; Y는 피리미딘이다; 헬릭스 2(H2)는 4개 이상의 염기쌍(즉, n이 1, 2, 3 또는 4)을 가지고, 헬릭스 5는 임의적으로 2개 이상의 염기의 길이를 가질 수 있다(바람직하게는, 3 내지 20개 염기, 즉 m이 1 내지 20이상). 헬릭스 2 및 헬릭스 5는 하나 이상의 염기에 의해 공유적으로 결합될 수 있다(즉, r이 1개 염기). 헬릭스 1, 4 또는 5는 리보자임 구조를 안정화하기 위하여 2개 이상의 염기쌍으로 신장될 수 있고(즉, 4 내지 20개 염기쌍), 바람직하게는 단백질 결합 부위이다. 각각의 경우, 각 N 및 N'는 독립적으로 정상 또는 변형된 염기이고, 각 대시는 가능한 염기쌍 상호작용을 나타낸다. 이러한 누클레오티드는 당, 염기 또는 인산기에서 변형될 수 있다. 완전한 염기쌍 형성은 헬릭스에서 요구되지는 않으나, 바람직한 것이다. 헬릭스 1 및 4는 염기쌍 형성이 유지되는 한 임의의 크기일 수 있다(즉, o 및 p는 각각 독립적으로 0 내지 임의의 수, 예컨대 20이다). 필수적 염기는 구조에서 특이적 염기로 도시되어 있으나, 당업자는 하나 이상이 화학적으로 변형될 수 있거나(비염기성, 염기, 당 및/또는 인산기 변형) 현저한 효과 없이 다른 염기로 대체될 수 있음을 인지할 것이다. 헬릭스 4는 2개의 별개의 분자로부터, 즉 연결 루프없는 분자로부터 형성될 수 있다. 연결 루프가 존재하는 경우, 이는 그 염기, 당 또는 인산기에 변형이 있거나 없는 리보누클레오티드일 수 있다. "q"는 2개 염기이다. 또한, 연길 루프는 비누클레오티드 링커 분자로 대체될 수 있다. H는 염기 A, U, 또는 C를 지칭한다. Y는 피리미딘 염기를 지칭한다. "___"는 공유 결합을 지칭한다[참조: Burke et al., 1996, Nucleic Acids ＆ Mol. Biol., 10, 129; Chowrira et al., US Patent No. 5,631,359].1 shows a secondary structural model for several different kinds of enzymatic nucleic acid molecules. Arrows indicate cleavage sites and target sequences. Dotted lines indicate tertiary interactions and base pair interactions. Group I introns: P1 to P9 exhibit various stem-loop structures. See Cech et al., 1994, Nature Struc. Bio., 1, 273]. RNase P (M1RNA): EGS represents an external guide sequence [Forster et al., 1990, Science, 249, 783; Pace et al., 1990, J. Biol. Chem., 265, 3587]. Group II introns: 5'SS means 5 'splice site; 3'SS means a 3'-splice site; IBS means intron binding site; EBS means exon binding site (Pyle et al., 1994, Biochemistry, 33, 2716). VS RNA: I to VI are meant to represent six stem-loop structures; Blocked regions are those that represent tertiary interactions. Collins, International PCT Publication No. WO 96/19577]. HDV ribozymes: I to IV are meant to represent four stem-loop structures. See Been et al., US Pat. 5,625,047 Hammerhead ribozymes: I-III means to represent three stem-loop structures; Stems I-III can be of any length and can be symmetrical or asymmetrical. Usman et al., 1996, Curr. Op. Struct. Bio., 1, 527]. Hairpin ribozymes: helix 1, 4 and 5 can be any length; Helix 2 is 3 to 8 base pairs in length; Y is pyrimidine; Helix 2 (H2) has four or more base pairs (ie, n is 1, 2, 3 or 4), and helix 5 may optionally have a length of two or more bases (preferably 3 to 20) Base, ie, m is at least 1-20. Helix 2 and helix 5 may be covalently bound by one or more bases (ie r is one base). Helix 1, 4 or 5 can be extended to two or more base pairs (ie 4 to 20 base pairs) to stabilize the ribozyme structure and is preferably a protein binding site. In each case, each N and N 'is independently a normal or modified base, and each dash represents a possible base pair interaction. Such nucleotides may be modified at sugar, base or phosphate groups. Complete base pairing is not required in the helix but is preferred. Helix 1 and 4 can be of any size as long as base pairing is maintained (ie, o and p are each independently 0 to any number, such as 20). While essential bases are shown as specific bases in the structure, those skilled in the art will recognize that one or more may be chemically modified (non-basic, base, sugar and / or phosphate group modifications) or may be replaced with other bases without significant effect. will be. Helix 4 can be formed from two separate molecules, that is, from a molecule without a linking loop. If a linking loop is present, it may be a ribonucleotide with or without modification to its base, sugar or phosphate group. "q" is two bases. In addition, the long loop can be replaced with a soap nucleotide linker molecule. H refers to base A, U, or C. Y refers to the pyrimidine base. "___" refers to a covalent bond. Burke et al., 1996, Nucleic Acids & Mol. Biol., 10, 129; Chowrira et al., US patent no. 5,631,359].

도 2는 수개의 제노타입으로부터 제조된 전사체를 절단하기 위하여 5' HCV UTR 보존 영역내의 다양한 부위를 표적화하는 리보자임의 능력을 나타내는 그래프이다.2 is a graph showing the ability of ribozymes to target various sites within the 5 ′ HCV UTR conserved region to cleave transcripts made from several genotypes.

도 3은 세포 배양에서 리보자임 매개된 루시페라제 활성의 감소를 설명하기 위하여 사용된 듀얼 리포터 시스템의 개략도이다.3 is a schematic of the dual reporter system used to account for the reduction of ribozyme mediated luciferase activity in cell culture.

도 4는 OST-7 세포에서 루시페라제 활성을 감소시키는 리보자임의 능력을 나타내는 그래프이다.4 is a graph showing the ability of ribozymes to reduce luciferase activity in OST-7 cells.

도 5는 비활성 대조와 비교하여, OST-7 세포에서 루시페라제 활성을 감소시키 위하여 표적 부위 HCV.5-313 및 HCV.5-318을 표적화하는 리보자임의 능력을 나타내는 그래프이다.5 is a graph showing the ability of ribozymes to target target sites HCV.5-313 and HCV.5-318 to reduce luciferase activity in OST-7 cells compared to inactive controls.

도 6 a는 HCV-폴리오 바이러스(PV) 복제에 대한 리보자임 처리의 효과를 설명하는 막대 그래프이다. 96-웰 플레이트의 HeLa 세포를 0.1의 다중 감염(MOI)으로 HCV-PV로 감염시켰다. 그 후, 바이러스 접종물을 5% 혈청 및 표시된 바와 같이 양이온성 지질과 복합체형성된 리보자임 또는 대조(200nM)를 함유한 배지로 대체시켰다. 24시간 후에, 세포를 동결/해동에 의해 3회 용해시켰고 바이러스를 플래크 검정에 의해 정량하였다. 스크램블링된 재조(SAC), 결합 대조(BAC), 3P=S 리보자임, 및 4P=S 리보자임이 표시된다. 플래크 형성 단위(pfu)/ml는 삼중 샘플의 평균+표준 편차(S.D.)로서 나타낸다.6A is a bar graph illustrating the effect of ribozyme treatment on HCV-poliovirus (PV) replication. HeLa cells in 96-well plates were infected with HCV-PV with a multiple infection (MOI) of 0.1. The virus inoculum was then replaced with medium containing 5% serum and ribozyme or control (200 nM) complexed with cationic lipids as indicated. After 24 hours, cells were lysed three times by freeze / thaw and viruses were quantified by plaque assay. Scrambled preparation (SAC), binding control (BAC), 3P = S ribozyme, and 4P = S ribozyme are indicated. Plaque forming units (pfu) / ml are expressed as mean + standard deviation (S.D.) of triplicate samples.

도 6b는 야생형 PV 복제에 대한 리보자임 처리의 효과를 설명하는 막대 그래프이다. 96-웰의 HeLa 세포를 30분간 MOI=0.05에서 야생형 PV로 감염시켰다. 모든 리보자임은 (B)중에 4P=S를 함유하였다. 플래크 형성 단위(pfu)/ml는 삼중 샘플의 평균+표준 편차(S.D.)로서 나타낸다.6B is a bar graph illustrating the effect of ribozyme treatment on wild type PV replication. 96-well HeLa cells were infected with wild-type PV at MOI = 0.05 for 30 minutes. All ribozymes contained 4P = S in (B). Plaque forming units (pfu) / ml are expressed as mean + standard deviation (S.D.) of triplicate samples.

도 7은 HCV RNA에 대하여 표적화된 다양한 해머헤드 리보자임 작제물의 개략도이다.7 is a schematic of various hammerhead ribozyme constructs targeted against HCV RNA.

도 8은 1회의 HCV-PV 감염에 대한 부위 183 리보자임 처리의 효과를 설명하는 그래프이다. 리보자임 또는 대조로 처리하기 전에 HeLa 세포를 30분간 MOI=5에서 HCV-PV로 감염시켰다. 세포를 6, 7, 또는 8시간후에 용해시켰고 바이러스를 플래크 검정에 의해 정량하였다. 리보자임 결합 아암(arm)/스템 Ⅱ 포맷(7/4, 7/3, 6/4, 6/3) 및 스크램블링된 대조(SAC, 7/4포맷)가 표시된다. 모두 4P=S 안정화를 함유하였다. 결과(pfu/ml)는 2중 샘플의 중간치±범위로 나타낸다.8 is a graph illustrating the effect of site 183 ribozyme treatment on one HCV-PV infection. HeLa cells were infected with HCV-PV at MOI = 5 for 30 minutes prior to treatment with ribozyme or control. Cells were lysed after 6, 7, or 8 hours and viruses were quantified by plaque assay. Ribozyme binding arm / Stem II format (7/4, 7/3, 6/4, 6/3) and scrambled control (SAC, 7/4 format) are shown. All contained 4P = S stabilization. Results (pfu / ml) are shown as median ± range of duplicate samples.

도 9는 본원에서 기술된 3개의 리보자임 모티프의 2차 구조 모델을 나타낸다.9 shows a secondary structural model of the three ribozyme motifs described herein.

도 10은 인터페론과 병용한 항-HCV 리보자임의 활성을 나타낸다. 결과(pfu/ml)는 2중 샘플의 중간치±범위로 나타낸다. BAC는 결합 약화된 대조 분자; IF는 인터페론; Rz은 HCV 부위 183을 표적으로 하는 해머헤드 리보자임; pfu는 플래크 형성 단위이다.10 shows the activity of anti-HCV ribozymes in combination with interferon. Results (pfu / ml) are shown as median ± range of duplicate samples. BACs are binding weakened control molecules; IF is interferon; Rz is a hammerhead ribozyme that targets HCV site 183; pfu is a plaque forming unit.

리보자임Ribozyme

7개 기본 종류의 천연의 효소적 RNA는 현재 공지되어 있다. 또한, 포스포디에스테르 결합의 절단 및 결합을 촉매할 수 있는 새로운 핵산 촉매를 이끌어내기 위하여 몇가지 시험관내 선택성(진화) 전략[참조: Orgel, 1979, Proc. R. Soc. London, B 205, 435]이 사용되어 왔다[참조: Joyce, 1989, Gene, 82, 83-87; Beaudery et al., 1992, Science 257, 635-641; Joyce, 1992, Scientific American 267, 90-97; Breaker et al., 1994, TIBTECH 12, 268; Bartel et al., 1993, Science 261: 1411-1418; Szostak, 1993, TIBS 17, 89-93; Kumar et al., 1995, FASEB J., 9, 1183; Breaker, 1996, Curr. Op. Biotech., 7, 442; Santoro et al., 1997, Proc. Natl. Acad. Sci., 94, 4262; Tang et al., 1997, RNA 3, 914; Nakamaye ＆ Eckstein, 1994, supra; Long ＆ Uhlenbeck, 1994, supra; Ishizaka et al., 1995, supra; Vaish et al., 1997, Biochemistry 36, 6495; 상기 문헌은 모두 본원에 참고문헌으로 삽입된다]. 각각은 생리적 조건하에서 트랜스에서 포스포디에스테르 결합의 가수분해를 포함한 일련의 반응을 촉매할 수 있다. 표 Ⅰ은 이러한 몇가지 리보자임의 특성을 요약하고 있다. 일반적으로, 효소적 핵산은 먼저 표적 RNA와 결합함으로써 작용한다. 이러한 결합은 표적 RNA를 절단시키는 작용을 하는 분자의 효소적 부분에 매우 근접한 효소적 핵산의 표적 결합 부위를 통하여 일어난다. 따라서, 효소적 핵산은 먼저 표적 RNA를 인식한 후 상보적인 염기쌍 형성을 통하여 표적 RNA와 결합하고 일단 올바른 부위에 결합되면, 효소적으로 작용하여 표적 RNA를 절단한다. 이러한 표적 RNA의 전략적 절단은 그의 엔코딩된 단백질의 직접적인 합성 능력을 파괴할 것이다. 효소적 핵산은 RNA 표적과 결합하여 이를 절단시킨 후에, RNA로부터 유리되어 다른 표적을 찾아 반복적으로 새로운 표적과 결합하고 절단시킬 수 있다.Seven basic kinds of natural enzymatic RNA are now known. In addition, several in vitro selectivity (evolution) strategies have been developed to elicit novel nucleic acid catalysts that can catalyze the cleavage and binding of phosphodiester bonds. See Orgel, 1979, Proc. R. Soc. London, B 205, 435 have been used (Joyce, 1989, Gene, 82, 83-87; Beaudery et al., 1992, Science 257, 635-641; Joyce, 1992, Scientific American 267, 90-97; Breaker et al., 1994, TIBTECH 12, 268; Bartel et al., 1993, Science 261: 1411-1418; Szostak, 1993, TIBS 17, 89-93; Kumar et al., 1995, FASEB J., 9, 1183; Breaker, 1996, Curr. Op. Biotech., 7, 442; Santoro et al., 1997, Proc. Natl. Acad. Sci., 94, 4262; Tang et al., 1997, RNA 3, 914; Nakamaye & Eckstein, 1994, supra; Long & Uhlenbeck, 1994, supra; Ishizaka et al., 1995, supra; Vaish et al., 1997, Biochemistry 36, 6495; All of which are incorporated herein by reference. Each can catalyze a series of reactions including hydrolysis of phosphodiester bonds in trans under physiological conditions. Table I summarizes the characteristics of some of these ribozymes. In general, enzymatic nucleic acids act by first binding to target RNA. This binding occurs through the target binding site of the enzymatic nucleic acid in close proximity to the enzymatic portion of the molecule that acts to cleave the target RNA. Thus, the enzymatic nucleic acid first recognizes the target RNA and then binds to the target RNA through complementary base pairing and, once bound to the correct site, acts enzymatically to cleave the target RNA. Strategic cleavage of such target RNA will destroy the direct synthetic ability of its encoded protein. After enzymatic nucleic acid binds to and cleaves an RNA target, it can be liberated from the RNA to find another target and to repeatedly bind and cleave the new target.

리보자임의 효소적 성질은 다른 기술에 비하여 장점이 있는데, 이는 치료에 영향을 주는데 필요한 리보자임의 농도가 보다 낮기 때문이다. 이러한 장점은 효소적으로 작용하는 리보자임의 능력을 반영하는 것이다. 따라서, 단일 리보자임 분자는 표적 RNA의 많은 분자를 절단시킬 수 있다. 또한, 리보자임은 고도로 특이적인 저해제이며, 그 저해의 특이성은 표적 RNA와의 결합의 염기쌍 형성 메카니즘 뿐만 아니라 표적 RNA 절단의 메카니즘에 의존한다. 절단 부위 근처에서 단일 미스매치, 또는 염기 치환은 리보자임의 효소적 활성을 완전히 제거하기 위하여 선택될 수 있다.The enzymatic properties of ribozymes have advantages over other techniques because of the lower concentrations of ribozyme required to affect treatment. This advantage reflects the ability of ribozymes to act enzymatically. Thus, a single ribozyme molecule can cleave many molecules of the target RNA. In addition, ribozymes are highly specific inhibitors, and the specificity of the inhibition depends on the mechanism of target RNA cleavage as well as the base pairing mechanism of binding to the target RNA. A single mismatch, or base substitution, near the cleavage site can be chosen to completely eliminate the enzymatic activity of the ribozyme.

엔도누클레아제 효소 활성을 가진 핵산 분자는 누클레오티드 염기 서열 특이적 방식으로 다른 별개의 RNA 분자를 반복적으로 절단시킬 수 있다. 이러한 효소적 핵산 분자는 궁극적으로 임의의 RNA 전사체를 표적화하여 시험관내에서 효율적인 절단이 이루어질 수 있다[참조: Zaung et al., 324, Nature 429 1986; Uhlenbeck, 1987 Nature 328, 596; Kim et al., 84 Proc. Natl. Acad. Sci. USA 8788, 1987; Dreyfus, 1988, Einstein Quart. J. Bio. Med., 6, 92; Haeloff and Gerlach, 334 Nature 585, 1988; Cech, 260 JAMA 3030, 1988; and Jefferies et al., 17 Nucleic Acids Research 1371, 1989; Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, Pnas 94, 4262].Nucleic acid molecules with endonuclease enzyme activity can repeatedly cleave other discrete RNA molecules in a nucleotide sequence specific manner. Such enzymatic nucleic acid molecules can ultimately target any RNA transcript, resulting in efficient cleavage in vitro. Zaung et al., 324, Nature 429 1986; Uhlenbeck, 1987 Nature 328, 596; Kim et al., 84 Proc. Natl. Acad. Sci. USA 8788, 1987; Dreyfus, 1988, Einstein Quart. J. Bio. Med., 6, 92; Haeloff and Gerlach, 334 Nature 585, 1988; Cech, 260 JAMA 3030, 1988; and Jefferies et al., 17 Nucleic Acids Research 1371, 1989; Chartrand et al., 1995, Nucleic Acids Research 23, 4092; Santoro et al., 1997, Pnas 94, 4262.

서열 특이성 때문에, 트랜스-절단 리보자임은 인간 질병의 치료제로서 유망하다[참조: Usman ＆ McSwiggen, 1995 Ann. Rep. Med. Chem. 30, 285-294; Christoffersen and Marr, 1995 J. Med. Chem. 38, 2023-2037]. 리보자임은 세포 RNA의 배경 내에서 특이적 RNA 표적을 절단하도록 고안될 수 있다. 이러한 절단 이벤트는 RNA를 비기능적으로 만들고 RNA로부터 단백질 발현을 폐기시킨다. 이러한 방식으로, 질병과 관련된 단백질의 합성은 선택적으로 억제될 수 있다.Because of sequence specificity, trans-cleaving ribozymes are promising as therapeutics for human diseases. Usman & McSwiggen, 1995 Ann. Rep. Med. Chem. 30, 285-294; Christoffersen and Marr, 1995 J. Med. Chem. 38, 2023-2037. Ribozymes can be designed to cleave specific RNA targets within the background of cellular RNA. These cleavage events make RNA nonfunctional and discard protein expression from RNA. In this way, the synthesis of proteins associated with the disease can be selectively inhibited.

HCV RNA에서 명시된 부위를 절단하는 리보자임은 C형 간염 바이러스에 의한 감염의 새로운 치료적 접근법을 나타낸다. 본 출원인은 리보자임이 HCV의 활성을 억제할 수 있고 리보자임의 촉매적 활성은 이들의 억제 효과에 요구됨을 시사한다. 당법자는 HCV RNA를 절단시키는 기타 리보자임이 용이하게 고안될 수 있고 본 발명에 속하는 것이 기술된 실시예로부터 자명하다는 것을 알게 될 것이다.Ribozymes that cleave specified sites in HCV RNA represent a new therapeutic approach for infection with hepatitis C virus. Applicants suggest that ribozymes can inhibit the activity of HCV and the catalytic activity of ribozymes is required for their inhibitory effect. Those skilled in the art will appreciate that other ribozymes for cleaving HCV RNA can be readily devised and are apparent from the described embodiments belonging to the present invention.

표적 부위Target site

유용한 리보자임을 위한 표적은 문헌[Draper et al., WO93/23569; Sullivan et al., WO93/23057; Thompson et al., WO94/02595; Draper et al., WO95/04818; McSwiggen et al., UC Patent 5,525,468, 모두 본원에 참고문헌으로 삽입됨]에 기재된 바에 따라 결정될 수 있다. 이들 문헌에 제공된 지침을 반복하기 보다 본원에서는 하기에 당해 분야에 국한되지 않는 이러한 방법의 특정 실시예를 제공한다. 이러한 표적에 대한 리보자임은 상기 출원에 기술된 바에 따라 고안 및 합성되어, 또한 기술된 바에 따라 시험관내 및 생체내에서 시험된다. 이러한 리보자임은 기술된 바에 따라 최적화되고 전달될 수도 있다.Targets for useful ribozymes are described in Draper et al., WO 93/23569; Sullivan et al., WO 93/23057; Thompson et al., WO 94/02595; Draper et al., WO 95/04818; McSwiggen et al., UC Patent 5,525,468, all of which are incorporated herein by reference. Rather than repeating the instructions provided in these documents, the following provides specific examples of such methods, which are not limited to the art below. Ribozymes for such targets are designed and synthesized as described in the above application, and also tested in vitro and in vivo as described. Such ribozymes may be optimized and delivered as described.

HCV RNA의 서열은 컴퓨터 폴딩 알고리즘을 사용하여 최적의 리보자임 표적 부위에 대하여 스크리닝되었다. 해머헤드 또는 헤어핀 리보자임 절단 부위가 확인되었다. 이들 부위는 표 Ⅳ 내지 Ⅷ에 제시된다(표에서 모든 서열은 5' 에서 3'방향이다). 표에서 누클레오티드 염기 위치는 지정된 유형의 리보자임에 의해 절단되는 부위로서 표시된다. 표에서 누클레오티드 염기 위치는 지정된 유형의 리보자임에 의해 절단되는 부위로서 표시된다.Sequences of HCV RNA were screened for optimal ribozyme target sites using computer folding algorithms. Hammerhead or hairpin ribozyme cleavage sites were identified. These sites are shown in Tables IV to VIII (all sequences in the table are in the 5 'to 3' direction). Nucleotide base positions in the table are indicated as sites cleaved by the designated type of ribozyme. Nucleotide base positions in the table are indicated as sites cleaved by the designated type of ribozyme.

HCV RNA가 특정 영역에서 고도로 상동적이기 때문에, 몇가지 리보자임 표적 부위도 상동적이다(표 Ⅳ 내지 Ⅷ 참조). 이러한 경우에, 단일 리보자임은 상이한 종류의 HCV RNA를 표적화할 것이다. 수종의 HCV RNA를 표적화하는 1개의 리보자임의 장점은 특히 이러한 RNA 하나 이상이 질병 상태에 기여할 수 있는 경우에 특히 명백하다.Because HCV RNA is highly homologous in certain regions, several ribozyme target sites are also homologous (see Tables IV to VIII). In such cases, a single ribozyme will target different kinds of HCV RNA. The advantage of one ribozyme for targeting several HCV RNAs is particularly evident when one or more of these RNAs can contribute to a disease state.

결합될 수 있고, 리보자임 서열이 적당한 2차 구조로 폴딩되는지를 평가하기 위하여 컴퓨터 폴딩에 의해 개별적으로 분석된 해머헤드 또는 헤어핀 리보자임을 고안하였다[참조: Jaeger et al., 1989 Proc. Natl. Sci. USA, 86, 7706]. 결합 아암(arm) 및 촉매 코아 사이에 불리한 분자내 상호작용을 갖는 리보자임은 고려의 대상에 제외하였다. 활성을 최적화하기 위하여 다양한 결합 아암(arm) 길이가 선택될 수 있다. 일반적으로, 각 아암(arm)에 5개 이상의 염기가 표적 RNA와 결합하거나 상호작용할 수 있다. 해머헤드 또는 헤어핀 모티프의 리보자임은 mRNA 메시지에서 다양한 부위에 어닐링되도록 고안되었다. 결합 아암(arm)은 상기 표적 부위 서열에 상보적이다.Hammerhead or hairpin ribozymes were individually analyzed by computer folding to assess whether the ribozyme sequence can be bound and folded into a suitable secondary structure. Jaeger et al., 1989 Proc. Natl. Sci. USA, 86, 7706]. Ribozymes having adverse intramolecular interactions between the binding arm and the catalytic core were excluded from consideration. Various binding arm lengths can be selected to optimize activity. In general, five or more bases in each arm can bind or interact with the target RNA. Ribozymes of hammerhead or hairpin motifs are designed to anneal to various sites in an mRNA message. The binding arm is complementary to the target site sequence.

리보자임 합성Ribozyme Synthesis

100개 누클레오티드를 초과하는 길이의 핵산의 합성은 자동화된 방법을 사용하기 어렵고 이러한 분자의 치료적 비용은 고가이다. 본 발명에서, 작은 핵산 모티프(예컨대, 해머헤드 또는 헤어핀 리보자임)가 외인성 전달을 위하여 사용된다. 이러한 분자의 간단한 구조는 mRNA 구조의 표적화된 영역을 공격하는 핵산의 능력을 증가시킨다. 그러나, 이러한 핵산 분자는 진핵성 프로모터로부터 세포내에서 발현될 수도 있다[예컨대, Izant and Weintraub, 1985 Science 229, 345; McGarry and Lindquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; SullengerScanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5; Kashani-Sabet et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res. 23, 2259]. 당업자는 임의의 핵산이 적당한 DNA/RNA 프로모터로부터 진핵세포에서 발현될 수 있음을 알고 있다. 이러한 핵산의 활성은 리보자임으로부터의 1차 전사로부터의 유리에 의해 증강될 수 있다[참조: Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595, 양자 모두 본원에서 참고문헌으로 삽입; Ohkawa et al., 1992 Nucleic Acids Symp. Ser. 27, 15-6; Taira et al., Nucleic Acids Res., 19, 5125-30; Venura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856].Synthesis of nucleic acids of more than 100 nucleotides in length is difficult to use automated methods and the therapeutic cost of such molecules is expensive. In the present invention, small nucleic acid motifs (eg hammerhead or hairpin ribozymes) are used for exogenous delivery. The simple structure of these molecules increases the ability of the nucleic acid to attack targeted regions of the mRNA structure. However, such nucleic acid molecules may also be expressed intracellularly from eukaryotic promoters (eg, Izant and Weintraub, 1985 Science 229, 345; McGarry and Lindquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; Sullenger Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5; Kashani-Sabet et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res. 23, 2259]. One skilled in the art knows that any nucleic acid can be expressed in eukaryotic cells from a suitable DNA / RNA promoter. The activity of such nucleic acids can be enhanced by free from primary transcription from ribozymes (Draper et al., PCT WO93 / 23569, and Sullivan et al., PCT WO94 / 02595, both of which are herein incorporated by reference). Insertion into the literature; Ohkawa et al., 1992 Nucleic Acids Symp. Ser. 27, 15-6; Taira et al., Nucleic Acids Res., 19, 5125-30; Venura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856].

실시예에서 리보자임은 화학적으로 합성되었다. 사용된 합성 방법은 문헌[참조: Ulseman et al., 1987 J. Am. Chem. Soc. 109, 7845; Scaringe et al., 1990 Nucleic Acids Res., 18, 5433; and Wincott et al., 1995 Nucleic Acids Res., 23, 2677-2684]에 기재된 정상 RNA 합성 방법을 따르며, 5'-말단에서 디메톡시트리틸, 및 3'-말단에서 포스포르아미다이트와 같은 일반적인 핵산 보호 및 커플링기를 사용한다. 소규모의 합성을 알킬실릴 보호된 누클레오티드에 대한 5분 커플링 단계 및 2'-O-메틸화된 누클레오티드에 대하여 2.5분 커플링 단계를 가진 변형된 2.5μmol 규모 프로토콜을 사용하여 394 Applied Biosystems, Inc 합성기로 수행하였다. 표 Ⅱ는 합성 주기에서 사용된 시약의 양 및 접촉 시간을 기재한다. 중합체 결합된 5'-히드록실기에 대하여 6.5배 과량(0.1M 163μL=16.3μmol)의 포스포르아미다이트 및 24배 과량(0.25M 238μL=59.5μmol)의 S-에틸 테트라졸을 각 커플링 주기에서 사용하였다. 394 Applied Biosystems, Inc 합성기상에서 평균 커플링 수율은 트리틸 분획의 비색 정량에 의해 측정하여 97.5 내지 99%이었다. 394 Applied Biosystems, Inc 합성기용 기타 올리고누클레오티드 합성 시약: 탈트리틸화 용액은 메틸렌 클로라이드중의 2% TCA(ABI)이었고; 캡핑은 THF중의 16% N-메틸 이미다졸(ABI) 및 THF중의 10% 아세트산 무수물/10% 2,6-루티딘으로 수행하였으며; 산화 용액은 THF중의 16.9mM I2, 49mM 피리딘, 9% 물(Millipore)이었다. B ＆ J 합성 등급 아세토니트릴을 시약 병으로부터 직접 사용하였다. S-에틸 테트라졸 용액(아세토니트릴중 0.25M)을 American International Chemical, Inc로부터 구입한 고체로부터 제조하였다.In the examples ribozymes were chemically synthesized. Synthetic methods used are described in Ulseman et al., 1987 J. Am. Chem. Soc. 109, 7845; Scaringe et al., 1990 Nucleic Acids Res., 18, 5433; and Wincott et al., 1995 Nucleic Acids Res., 23, 2677-2684, followed by dimethoxytrityl at the 5'-end, and phosphoramidite at the 3'-end. Common nucleic acid protection and coupling groups are used. Small scale synthesis was performed on a 394 Applied Biosystems, Inc synthesizer using a modified 2.5 μmol scale protocol with a 5 minute coupling step for alkylsilyl protected nucleotides and a 2.5 minute coupling step for 2′-O-methylated nucleotides. Was performed. Table II lists the amounts and contact times of the reagents used in the synthesis cycle. Coupling 6.5-fold excess (0.1M 163μL = 16.3μmol) phosphoramidite and 24-fold excess (0.25M 238μL = 59.5μmol) S-ethyl tetrazole with each polymer bound 5'-hydroxyl group Used in cycle. The average coupling yield on the 394 Applied Biosystems, Inc synthesizer was 97.5 to 99% as measured by the colorimetric quantification of the trityl fraction. Other oligonucleotide synthesis reagents for the 394 Applied Biosystems, Inc synthesizer: The detritylation solution was 2% TCA (ABI) in methylene chloride; Capping was performed with 16% N-methyl imidazole (ABI) in THF and 10% acetic anhydride / 10% 2,6-lutidine in THF; The oxidation solution was 16.9 mM I 2 , 49 mM pyridine, 9% water (Millipore) in THF. B & J synthetic grade acetonitrile was used directly from the reagent bottle. S-ethyl tetrazole solution (0.25M in acetonitrile) was prepared from a solid purchased from American International Chemical, Inc.

RNA의 탈보호는 하기와 같이 수행하였다. 중합체 결합된, 트리틸 제거된 올리고리보누클레오티드를 합성 컬럼으로부터 4mL 유리 스크류 상부 바이알로 옮겨서 65℃에서 10분간 메틸아민(MA) 용액에 현탁시켰다. -20℃ 이하로 냉각시킨 후에, 상청액을 중합체 지지체로부터 제거하였다. 지지체를 EtOH: MeCN:H2O/3:1:1의 1.0mL로 3회 세척하였고, 보르텍싱시킨 다음 상청액을 최초의 상청액에 첨가하였다. 올리고리보누클레오티드를 함유한 혼합된 상청액을 건조시켜 백색 분말로 하였다.Deprotection of RNA was performed as follows. Polymer bound, tritylated oligoribonucleotides were transferred from the synthesis column into 4 mL glass screw top vials and suspended in methylamine (MA) solution at 65 ° C. for 10 minutes. After cooling to −20 ° C. or less, the supernatant was removed from the polymer support. The support was washed three times with 1.0 mL of EtOH: MeCN: H 2 O / 3: 1: 1, vortexed and then the supernatant was added to the original supernatant. The mixed supernatant containing oligoribonucleotides was dried to a white powder.

염기-탈보호된 올리고리보누클레오티드를 무수 TEA·HF/NMP 용액(1.4M HF 농도를 제공하기 위한 1.5mL N-메틸피롤리딘온, TEA 750μL 및 TEA·3HF 1.0mL의 용액 250μL)에 재현탁시켰고 1시간 30분 동안 65℃로 가열하였다. 생성된 완전히 탈보호된 올리고머를 음이온 교환 탈염 이전에 50mM TEAB(9mL)로 담금질하였다.Base-deprotected oligoribonucleotides were resuspended in anhydrous TEA.HF / NMP solution (250 μL of 1.5 mL N-methylpyrrolidinone, 750 μL of TEA and 1.0 mL of TEA · 3HF to provide 1.4 M HF concentration). Heated to 65 ° C. for 1 hour 30 minutes. The resulting fully deprotected oligomer was quenched with 50 mM TEAB (9 mL) prior to anion exchange desalting.

탈보호된 올리고머의 음이온 교환 탈염을 위하여 TEAB 용액을 50mM TEAB(10mL)로 미리 세척한 Qiagen 500음이온 교환 카트리지(Qiagen, Inc)에 로딩시켰다. 로딩된 카트리지를 50mM TEAB(10mL)로 세척한 후에, RNA를 2M TEAB(10mL)로 용리시켰고 건조시켜 백색 분말로 하였다.Qiagen 500 pre-washed TEAB solution with 50 mM TEAB (10 mL) for anion exchange desalting of deprotected oligomers Loaded in anion exchange cartridge (Qiagen, Inc). After the loaded cartridge was washed with 50 mM TEAB (10 mL), RNA was eluted with 2M TEAB (10 mL) and dried to a white powder.

비활성 해머헤드 리보자임을 G5A6의 순서를 바꾸어 치환하고 A14대신에 U로 치환함으로써 합성하였다[Hertel, K. J., et al., 1992, Nucleic Acids Res. 20, 3252로부터 번호매김]. 비활성 리보자임은 G5 대신에 U 그리고 A14 대신에 U로 치환함으로써 합성될 수도 있다. 몇가지 경우에, 기질 결합 아암(arm)의 서열을 무작위화시킨 반면, 전체적인 염기 조성은 유지하였다.Inactive hammerhead ribozymes were synthesized by reversing the order of G 5 A 6 and substituting U for A 14 [Hertel, KJ, et al., 1992, Nucleic Acids Res. Numbered from 20, 3252]. Inactive ribozymes may be synthesized by substituting U for G5 and U for A14. In some cases, the sequence of the substrate binding arm was randomized while the overall base composition was maintained.

평균적인 단계식 커플링 수율은 98%를 초과하였다[참조: Wincott et al., 1995 Nucleic Acids Res. 23, 2677-2684].Average stepwise coupling yields exceed 98%. Wincott et al., 1995 Nucleic Acids Res. 23, 2677-2684].

헤어핀 리보자임은 2개 부분으로 합성되며 활성 리보자임을 재작제하기 위하여 어닐링된다[참조: Chowrira and Burke, 1992 Nucleic Acids Res. 20, 2835-2840]. 리보자임은 박테리오파지 T7 RNA 중합효소를 사용하여 DNA 주형으로부터 합성될 수도 있다[참조: Miligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51].Hairpin ribozymes are synthesized in two parts and annealed to reconstruct active ribozymes. Chowrira and Burke, 1992 Nucleic Acids Res. 20, 2835-2840]. Ribozymes can also be synthesized from DNA templates using bacteriophage T7 RNA polymerase. Miligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51].

리보자임은 안정성 및/또는 촉매활성을 증강시키기 위하여 누클레아제 내성 기, 예컨대 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H를 사용한 변형, 누클레오티드 염기 변형에 의해 변형된다[참조: Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090].Ribozyme may be used to convert nuclease resistant groups such as 2'-amino, 2'-C-allyl, 2'-fluoro, 2'-0-methyl, 2'-H to enhance stability and / or catalytic activity. Modified by nucleotide base modifications used. See Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090].

리보자임은 일반적인 방법을 사용하는 겔 전기영동에 의해 정제되거나 고압 액체 크로마토그래피(HPLC: Stinchcomb et al., International PCT Publication No. WO95/23225 참조, 전문이 본원에 참고문헌으로 삽입)에 의해 정제되어 물에 재현탁된다.Ribozymes can be purified by gel electrophoresis using conventional methods or by high pressure liquid chromatography (see HPLC: Stinchcomb et al., International PCT Publication No. WO95 / 23225, incorporated herein by reference in its entirety). Resuspend in water.

본 연구에 유용한 화학적으로 합성된 리보자임의 서열은 표 Ⅳ 내지 Ⅸ에 제시된다. 당업자는 이러한 서열이 리보자임의 효소적 부분(결합 아암(arm)을 제외한 모두)이 활성에 영향을 미치도록 변형된 보다 많은 이러한 서열중에서 대표적인 것일 뿐이라는 것을 인지할 것이다. 예컨대, 해머헤드 리보자임의 스템-루프 Ⅱ 서열은 최소 2개의 염기쌍 형성된 스템 구조가 형성되는 경우 임의의 서열을 함유하도록 변화할 수 있다. 유사하게, 헤어핀 리보자임의 스템-루프 Ⅳ 서열은 최소 2개의 염기쌍 형성된 스템 구조가 형성되는 경우 임의의 서열을 함유하도록 변화할 수 있다(치환, 결실, 및/또는 삽입). 바람직하게는, 200개 이하의 염기가 이러한 위치에 삽입된다. 표 Ⅳ 내지 Ⅸ에 기재된 서열은 리보누클레오티드 또는 기타 누클레오티드 또는 비누클레오티드로 형성될 수 있다. 이러한 리보자임(효소적 활성을 가진)은 표에서 상세하게 기술한 리보자임과 동등하다.Chemically synthesized ribozyme sequences useful in this study are shown in Tables IV-VII. Those skilled in the art will appreciate that such sequences are merely representative of many more such sequences in which the enzymatic portion of the ribozyme (all but the binding arm) has been modified to affect activity. For example, the stem-loop II sequence of a hammerhead ribozyme can be changed to contain any sequence when at least two base paired stem structures are formed. Similarly, the stem-loop IV sequence of hairpin ribozyme can be changed (substituted, deleted, and / or inserted) to contain any sequence when at least two base paired stem structures are formed. Preferably, up to 200 bases are inserted at this position. The sequences set forth in Tables IV-VII may be formed of ribonucleotides or other nucleotides or soap nucleotides. This ribozyme (with enzymatic activity) is equivalent to the ribozyme described in detail in the table.

리보자임 활성의 최적화Optimization of Ribozyme Activity

본 발명에서 기술된 리보자임의 촉매적 활성은 문헌[참조: Draper et al., supra]에 의해 기술된 바와 같이 최적화될 수 있다. 상세한 사항은 여기서 반복하지 않겠지만, 리보자임 결합 아암(arm) 길이의 변화, 또는 혈청 리보누클레아제에 의한 분해를 방지하고/거나 효소적 활성을 증강시키는 변형(염기, 당 및/또는 인산기)을 가진 리보자임을 화학적으로 합성하는 것을 포함한다[참조: Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Bioche. Sci. 17, 334; Usman et al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162; Sproat, US Patent No. 5,334,711; and Burgin et al., supura; 이들 모두는 효소적 RNA 분자의 염기, 인산 및/또는 당 부분에 이루어질 수 있는 다양한 화학적 변형을 기술한다]. 세포에서 그의 효능, 및 RNA 합성 시간을 단축하기 위하여 스템 루프 구조로부터 염기의 제거를 증강하고 화학적 요구조건을 감소시키는 변형이 바람직하다[이들 공보 모두는 본원에서 참고문헌으로 삽입된다].The catalytic activity of the ribozymes described herein can be optimized as described by Draper et al., Supra. Details will not be repeated here, but modifications (base, sugar and / or phosphate groups) that prevent changes in ribozyme binding arm length, or degradation by serum ribonucleases and / or enhance enzymatic activity. Chemically synthesizing ribozymes with Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren, 1992 Trends in Bioche. Sci. 17, 334; Usman et al., International Publication No. WO 93/15187; and Rossi et al., International Publication No. WO 91/03162; Sproat, US Patent No. 5,334,711; and Burgin et al., supura; All of which describe the various chemical modifications that can be made to the base, phosphoric and / or sugar moieties of an enzymatic RNA molecule. Modifications that enhance the removal of bases from the stem loop structure and reduce chemical requirements in order to shorten their potency in the cell, and RNA synthesis time are preferred. All of these publications are incorporated herein by reference.

촉매작용에 현저한 영향없이 그의 누클레아제 안정성 및 효능이 현저히 증강된 효소적 핵산 분자로 도입될 수 있는 당 및 인산 변형을 기술한 당해 분야의 몇가지 예가 있다. 리보자임은 안정성 및/또는 촉매적 활성을 증강시키기 위하여 슬한 증강 누클레아제 내성 기, 예컨대 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H를 사용한 변형, 누클레오티드 염기 변형에 의해 변형된다[참조: Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090]. 효소적 핵산 분자의 당변형은 당해 분야에서 널리 기술되어 왔다[참조: Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565-568; Pieken et al., Science 1991, 253, 314-317; Usman and Cedergren, 1992 Trends in Bioche. Sci. 1992, 17, 334-339; Usman et al., International Publication No. WO 93/15187; Sproat, US Patent No. 5,334,711; and Beigelman et al., 1995 J. Biol. Chem. 270, 25702; 이들 문헌 모두는 전문이 본원에서 참고문헌으로 삽입된다]. 이러한 간행물은 촉매작용의 저해없이 당, 염기 및/또는 인산기 변형 등의 리보자임내로의 혼입 위치를 결정하기 위한 일반적인 방법 및 전략을 기술하며, 본원에서 참고문헌으로 삽입된다. 이러한 교시의 관점에서, 본 발명의 핵산 촉매를 변형시키기 위하여 유사한 변형이 본원에서 기술된 바와 같이 사용될 수 있다.There are several examples in the art that describe sugar and phosphoric acid modifications that can be introduced into enzymatic nucleic acid molecules whose remarkably enhanced nuclease stability and efficacy are not significantly affected by catalysis. Ribozymes can be used to enhance enhanced nuclease resistance groups such as 2'-amino, 2'-C-allyl, 2'-fluoro, 2'-0-methyl, 2 'to enhance stability and / or catalytic activity. Modified with -H, nucleotide base modified by Usman and Cedergren, 1992 TIBS 17, 34; Usman et al., 1994 Nucleic Acids Symp. Ser. 31, 163; Burgin et al., 1996 Biochemistry 6, 14090]. Sugar modifications of enzymatic nucleic acid molecules have been widely described in the art. See, Eckstein et al., International Publication No. WO 92/07065; Perrault et al., 1990 Nature 344, 565-568; Pieken et al., Science 1991, 253, 314-317; Usman and Cedergren, 1992 Trends in Bioche. Sci. 1992, 17, 334-339; Usman et al., International Publication No. WO 93/15187; Sproat, US Patent No. 5,334,711; and Beigelman et al., 1995 J. Biol. Chem. 270, 25702; All of these documents are incorporated herein by reference in their entirety. Such publications describe general methods and strategies for determining the site of incorporation into ribozymes, such as sugar, base and / or phosphate group modifications, without inhibiting catalysis, and are incorporated herein by reference. In view of this teaching, similar modifications can be used as described herein to modify the nucleic acid catalyst of the present invention.

효소족 활성을 유지 또는 증강시키는 화학적 변형을 가진 핵산 촉매가 제공된다. 이러한 핵산은 일반적으로 비변형된 핵산보다는 누클레아제에 대해 보다 내성이기도 하다. 따라서, 세포 및/또는 생체내에서 활성은 현저하게 감소되지 않을 수 있다. 본원에서 예시된 바와 같이, 이러한 리보자임은 활성이 전체적으로 10배 감소될지라도 세포 및/또는 생체내에서 유용하다[참조: Burgin et al., 1996, Biochemistr, 35, 14090]. 본원에서 이러한 리보자임은 모든 RNA 리보자임에 대한 효소적 활성을 "유지"하는 것으로 언급된다.Nucleic acid catalysts having chemical modifications that maintain or enhance enzymatic family activity are provided. Such nucleic acids are generally more resistant to nucleases than to unmodified nucleic acids. Thus, activity may not be significantly reduced in cells and / or in vivo. As exemplified herein, such ribozymes are useful in cells and / or in vivo even though the activity is reduced by a 10-fold overall (Burgin et al., 1996, Biochemistr, 35, 14090). Such ribozymes are referred to herein as "maintaining" the enzymatic activity for all RNA ribozymes.

외인성으로 전달되는 치료적 리보자임은 표적 RNA의 번역이 불필요한 단백질의 수준을 감소시키기에 충분히 오랫동안 억제될 때까지 세포내에서 최적의 안정을 가져야 한다. 이러한 기간은 질병 상태에 따라 수시간 내지 수일로 변화한다. 분명히, 리보자임은 유효한 세포내 치료제로서 기능하기 위해서는 누클레아제에 내성이어야 한다. RNA의 화학적 합성에서의 개선[참조: Wincott et al., 1995 Nucleic Acids Res. 23, 2677; 본원에서 참고문헌으로 삽입]이 상기한 바와 같은 누클레아제 안정성을 증가시키기 위하여 누클레오티드 변형을 도입함으로써 리보자임을 변형시키는 가능성을 확대시켰다.Exogenously delivered therapeutic ribozymes should have optimal stability in cells until translation of the target RNA is inhibited long enough to reduce the level of unnecessary protein. This period varies from hours to days depending on the disease state. Clearly, ribozymes must be resistant to nucleases to function as an effective intracellular therapeutic. Improvement in chemical synthesis of RNA [Wincott et al., 1995 Nucleic Acids Res. 23, 2677; Inserted herein by reference expands the possibility of modifying ribozymes by introducing nucleotide modifications to increase nuclease stability as described above.

본원에서 사용된 "누클레오티드"는 당해 분야에서 잘 알려진 천연 염기(표준), 및 변형된 염기를 포함하는 것으로 당해 분야에서 인식되는 것이다. 이러한 염기는 일반적으로 당 부분의 1' 위치에 위치한다. 누클레오티드는 일반적으로 염기, 당 및 인산기를 포함한다. 누클레오티드는 당, 인산 및/또는 염기 부분에서 비변형되거나 변형될 수 있다(또한, 누클레오티드 유사체, 변형된 누클레오티드, 비천연 누클레오티드, 비표준형 누클레오티드 등과 상호교환적으로 언급되기도 한다; Usman and McSwiggen, supra; Eckstein et al., International Publication No. WO 92/07065; Usman et al., International Publication No. WO 93/15187; 모두 본원에서 참고문헌으로 삽입). 당해 분야에서 공지된 변형된 핵산 염기의 몇가지 예가 있으며, 최근 Limbach 등[1994, Nucleic Acids Res. 22, 2183]에 의해 요약되었다. 촉매적 활성에 현저한 영향을 미치지 않고 효소적 핵산에 도입될 수 있는 염기 변형의 비제한적인 예 몇가지는 이노신, 퓨린, 피리딘-4-온, 피리딘-2-온, 페닐, 슈도유라실, 2,4,6-트리메톡시 벤젠, 3-메틸 우라실, 디히드로우리딘, 나프틸, 아미노페닐, 5-알킬시티딘(예컨대, 5-메틸시티딘), 5-알킬우리딘(예컨대, 리보티미딘), 5-할로우리딘(에컨대, 5-브로모우리딘) 또는 6-아자피리미딘 또는 6-알킬피리미딘(에컨대,. 6-메틸우리딘) 및 기타를 포함한다[참조: Burgin et al., 1996, Biochemistr, 35, 14090]. 본 측면에서, "변형된 염기"는 1' 위치에서 아데닌, 구아닌, 시토신 및 우라실이외의 누클레오티드 염기 또는 이들의 균등물을 의미한다; 이러한 염기는 효소의 촉매 코아내에서 및/또는 기질 결합 영역에서 사용될 수 있다.As used herein, “nucleotide” is one recognized in the art to include natural bases (standards) well known in the art, and modified bases. Such bases are generally located at the 1 'position of the sugar moiety. Nucleotides generally include bases, sugars, and phosphoric acid groups. Nucleotides may be unmodified or modified in sugar, phosphoric and / or base moieties (also referred to interchangeably with nucleotide analogues, modified nucleotides, non-natural nucleotides, non-standard nucleotides, etc.); Usman and McSwiggen, supra; Eckstein et al., International Publication No. WO 92/07065; Usman et al., International Publication No. WO 93/15187; all incorporated herein by reference). There are several examples of modified nucleic acid bases known in the art, and recently described in Limbach et al. [1994, Nucleic Acids Res. 22, 2183. Some non-limiting examples of base modifications that can be introduced into enzymatic nucleic acids without significantly affecting catalytic activity are inosine, purine, pyridin-4-one, pyridin-2-one, phenyl, pseudouracil, 2, 4,6-trimethoxy benzene, 3-methyl uracil, dihydrouridine, naphthyl, aminophenyl, 5-alkylcytidine (eg 5-methylcytidine), 5-alkyluridine (eg ribotimi Dins), 5-halouridines (eg 5-bromouridines) or 6-azapyrimidines or 6-alkylpyrimidines (eg. 6-methyluridines) and others. et al., 1996, Biochemistr, 35, 14090. In this aspect, "modified base" means a nucleotide base other than adenine, guanine, cytosine and uracil or their equivalents at the 1 'position; Such bases can be used in the catalytic core of the enzyme and / or in the substrate binding region.

"비염기성(abasic)"은 염기 1개가 부족하거나 1' 위치에서 염기 대신 다른 화학적 기를 가진 당부분을 의미한다."Abasic" means a sugar moiety that lacks one base or has a different chemical group in place of the base at the 1 'position.

"비변형된 누클레오시드"는 β-D-리보푸라노오스의 1' 탄소에 결합된 아데닌, 시토신, 구아닌, 우라실 염기중 하나를 의미한다."Unmodified nucleoside" means one of the adenine, cytosine, guanine, uracil bases bound to the 1 'carbon of β-D-ribofuranose.

"변형된 누클레오시드"는 비변형된 누클레오티드 염기, 당 및/또는 인산의 화학 구조에 변형을 함유한 임의의 누클레오티드 염기를 의미한다."Modified nucleotide" means any nucleotide base containing modifications in the chemical structure of the unmodified nucleotide base, sugar and / or phosphoric acid.

리보자임의 유용성을 증가시키기 위하여 리보자임 구조에 대한 다양한 변형이 이루어질 수 있다. 이러한 변형은 저장기간, 생체내 반감기, 안정성 및 세포막 침투를 증가시키기 위한 표적 부위로의 이러한 리보자임의 도입의 용이성을 증가시킬 것이고, 표적 세포의 인식 및 결합 능력을 부여할 것이다.Various modifications to the ribozyme structure can be made to increase the usefulness of the ribozyme. Such modifications will increase the ease of incorporation of such ribozymes into target sites to increase shelf life, in vivo half-life, stability and cell membrane penetration and confer the ability of recognition and binding of target cells.

리보자임의 투여Administration of Ribozyme

설리반(Sullivan) 등[참조: PCT WO 94/02595]은 효소적 RNA 분자의 전달을 위한 일반적인 방법을 기술한다. 리보자임은 리포좀으로의 캡슐화, 이온토포레시스, 또는 히드로겔, 시클로덱스티린, 생체분해성 나노입자, 및 생체부착성 마이크로스피어와 같은 기타 비히클에 혼입에 의한 방법을 포함하지만 이에 한정되지 않는 당업자에게 공지된 다양한 방법에 의해 세포에 투여될 수 있다. 몇가지 증후에 대하여, 리보자임은 상기 비히클와 함께 또는 없이 세포 또는 조직으로 생체외에서 직접 전달될 수 있다. 대안적으로, RNA/비히클 조합은 직접 주사 또는 카테테르, 주입 펌프 또는 스텐트를 사용하여 국소적으로 전달된다. 다른 전달 경로는 혈관내, 근육내, 피하 또는 관절 주사, 에어로솔 흡입, 경구(정제 또는 필의 형태), 국소, 전신, 안내, 복강내 및/또는 초내 전달을 포함하나, 이에 한정되지 않는다. 리보자임 전달 및 투여에 관한 보다 상세한 설명은 본원에 참고문헌으로 삽입된 문헌[Sullivan et at., supra and Draper et al., PCT WO93/23569]에 제공된다.Sullivan et al. (PCT WO 94/02595) describe a general method for the delivery of enzymatic RNA molecules. Ribozymes are known to those of skill in the art, including but not limited to, encapsulation into liposomes, iontophoresis, or incorporation into other vehicles such as hydrogels, cyclodextrins, biodegradable nanoparticles, and bioadhesive microspheres. The cells can be administered by a variety of known methods. For some symptoms, ribozymes can be delivered in vitro directly to cells or tissues with or without the vehicle. Alternatively, RNA / vehicle combinations are delivered topically using direct injection or catheters, infusion pumps or stents. Other routes of delivery include, but are not limited to, intravascular, intramuscular, subcutaneous or joint injection, aerosol inhalation, oral (in the form of tablets or pills), topical, systemic, intraocular, intraperitoneal and / or intradermal delivery. Further details regarding ribozyme delivery and administration are provided in Sullivan et at., Supra and Draper et al., PCT WO 93/23569, incorporated herein by reference.

본 발명의 분자는 약제로서 사용될 수 있다. 약제는 환자에서 질병 상태의 발생을 예방, 억제하거나 치료(증상을 어느 정도, 바람직하게는 모두 완화)한다.The molecules of the invention can be used as medicaments. The medicament prevents, inhibits or treats (to some extent, preferably alleviates) the disease state in the patient.

본 발명의 음으로 하전된 폴리누클레오티드는 약학 조성물을 형성하기 위하여 안정화제, 완충제 등을 함유 또는 함유하지 않는 임의의 표준 수단에 의해 환자에 투여(예컨대, RNA, DNA 또는 단백질) 및 도입될 수 있다. 지질 또는 리포좀 전달 메카니즘을 사용하도자 할 경우에는, 제형화를 위한 표준 프로토콜이 수반될 수 있다. 본 발명의 조성물은 경구용 정제, 캡슐 또는 엘릭시르; 직장 투여용 좌제; 주사 투여용 멸균 용액 및 현탁액 등으로 제형화되어 사용될 수도 있다.The negatively charged polynucleotides of the present invention may be administered (eg, RNA, DNA or protein) and introduced to a patient by any standard means with or without stabilizers, buffers, etc. to form pharmaceutical compositions. . If one wishes to use a lipid or liposome delivery mechanism, standard protocols for formulation may be involved. Compositions of the present invention may be used in oral tablets, capsules or elixirs; Suppositories for rectal administration; It may be formulated into sterile solutions and suspensions for injection administration and the like.

본 발명은 또한 기술된 화합물의 약제학적으로 허용되는 제형을 포함한다. 이러한 제형은 상기 화합물의 염, 예컨대 산부가염, 예컨대 염산, 브롬화수소산, 아세트산, 및 벤젠술폰산의 염을 포함한다.The present invention also includes pharmaceutically acceptable formulations of the compounds described. Such formulations include salts of the compounds, such as acid addition salts such as hydrochloric acid, hydrobromic acid, acetic acid, and salts of benzenesulfonic acid.

약학 조성물 또는 제형은, 예컨대 세포 또는 환자, 바람직하게는 사람에게 전신 투여에 적당한 형태의 조성물 또는 제형을 지칭한다. 적당한 형태는 부분적으로는 예컨대 경구, 경피, 또는 주사 투여와 같은 투여 경로에 의존한다. 이러한 형태는 조성물 또는 제형이 표적 세포(즉, 음으로 하전된 중합체가 전달되고자 하는 세포)에 전달하는 것을 방해해서는 안된다. 예컨대, 혈류로 주입된 약학 조성물은 가용성이어야 한다. 다른 인자들이 당해 분야에서 공지되어 있으며, 독성 및 조성물 또는 제형이 효과를 발휘하는 것을 방해하는 형태와 같은 고려사항을 포함한다.A pharmaceutical composition or formulation refers to a composition or formulation, eg, in a form suitable for systemic administration to a cell or patient, preferably a human. Proper form depends, in part, on the route of administration, such as oral, transdermal, or injection administration. This form should not interfere with the delivery of the composition or formulation to the target cell (ie, the cell to which the negatively charged polymer is intended to be delivered). For example, pharmaceutical compositions injected into the bloodstream should be soluble. Other factors are known in the art and include considerations such as toxicities and forms that interfere with the effectiveness of the composition or formulation.

"전신 투여"는 생체내에서 약물이 혈류중에 전신적으로 흡수 또는 축적된 후에 전신을 통하여 분포되는 것을 의미한다. 전신 흡수를 일으키는 투여 경로는 제한이 없이 정맥내, 피하, 복강내, 흡입, 경구, 폐내 및 근육내를 포함한다. 이들 투여 경로 각각은 목적하는 음으로 하전된 중합체, 예컨대 핵산을 접근가능한 질병 조직에 노출시킨다. 약물의 순환계로의 유입속도는 분자량 또는 크기의 함수인 것으로 증명되었다. 본 발명의 화합물을 포함한 리포좀 또는 기타 약물 담체의 사용은 잠재적으로 예컨대 세망내피계(RES)의 조직과 같은 특정 조직 유형으로 약물을 를 국재화시킬 수 있다. 림프구 및 마크로파지와 같은 세포의 표면과 약물의 결합을 촉진할 수 있는 리포좀 제형도 유용하다. 이러한 접근법은 마크로파지 및 림프구의 HCV 감염된 간세포와 같은 비정상 세포의 면역 인식의 특이성을 이용함으로써 표적 세포로 약물의 전달의 증가를 제공할 수 있다."Whole body administration" means that the drug is distributed throughout the body in vivo after the drug is systemically absorbed or accumulated in the bloodstream. Routes of administration causing systemic absorption include, but are not limited to, intravenous, subcutaneous, intraperitoneal, inhalation, oral, intrapulmonary and intramuscular. Each of these routes of administration exposes the desired negatively charged polymer, such as nucleic acid, to accessible diseased tissue. The rate of entry of the drug into the circulation has proved to be a function of molecular weight or size. The use of liposomes or other drug carriers, including the compounds of the present invention, can potentially localize the drug into certain tissue types, such as, for example, the tissue of the reticuloendothelial system (RES). Liposomal formulations that can facilitate the binding of drugs to the surface of cells such as lymphocytes and macrophages are also useful. This approach can provide for increased delivery of drugs to target cells by exploiting the specificity of immune recognition of abnormal cells such as HCV infected hepatocytes of macrophages and lymphocytes.

본 발명은 또한 폴리(에틸렌글리콜)지질을 함유하는 표면 변형된 리포좀(PEG-변형된, 또는 장기간 순환성 리포좀 또는 스텔쓰(stealth) 리포좀)을 포함하는 조성물의 용도를 특징으로 한다. 이러한 제형은 표적 조직에서 약물의 축적을 증가시키는 방법을 제공한다. 이러한 종류의 약물 담체는 단핵성 식세포계(MPS 또는 RES)에 의한 옵소닌화 및 제거를 방해하여, 혈류 순환 시간을 장기화하고 캡슐화된 약물에 대한 조직 노출을 증가시킬 수 있다[참조: Lasic et al., Chem. Rev. 1995, 95, 2601-2627; Ishigawa et al., Chem, Pham. Bull. 1995, 43, 1005-1011]. 이러한 리포좀은 종양에 선택적으로 축적되는 것으로 나타났고, 이는 혈관신생된 표적 조직으로 침윤 및 포획에 의한 것으로 추정된다[참조: Lasic et al., Chem. Rev. 1995, 267, 1275-1276; Oku et al., 1995, Biochem. Biophysis. Acta, 1238, 86-90]. 장기간 순환하는 리포좀은 MPS의 조직에 축적되는 것으로 공지된 종래의 양이온성 리포좀에 비교하여 특히 DNA 및RNA의 약물동력학 및 약물작용학을 증가시킨다[참조: Liu et al., J. Biol. Chem. 1995, 42, 24864-24870; Choi et al., International PCT Publication No. WO96/10390; Holland et al., International PCT Publication No. WO96/10392; 이들 모두는 본원에 참고문헌으로 삽입된다]. 이들 모두는 본원에 참고문헌으로 삽입된다.The invention also features the use of a composition comprising surface modified liposomes (PEG-modified or long-term circulating liposomes or stealth liposomes) containing poly (ethyleneglycol) lipids. Such formulations provide a method of increasing the accumulation of drugs in target tissues. Drug carriers of this kind can interfere with opsonization and elimination by the mononuclear phagocyte system (MPS or RES), prolonging blood flow circulation time and increasing tissue exposure to encapsulated drugs. Lasic et al. Chem. Rev. 1995, 95, 2601-2627; Ishigawa et al., Chem, Pham. Bull. 1995, 43, 1005-1011. These liposomes have been shown to accumulate selectively in tumors, presumably due to infiltration and capture into angiogenic target tissues. Lasic et al., Chem. Rev. 1995, 267, 1275-1276; Oku et al., 1995, Biochem. Biophysis. Acta, 1238, 86-90]. Long-circulating liposomes increase the pharmacokinetics and pharmacodynamics of DNA and RNA, in particular, compared to conventional cationic liposomes known to accumulate in the tissues of MPS. Liu et al., J. Biol. Chem. 1995, 42, 24864-24870; Choi et al., International PCT Publication No. WO96 / 10390; Holland et al., International PCT Publication No. WO96 / 10392; All of which are incorporated herein by reference]. All of which are incorporated herein by reference.

또한, 다른 양이온성 분자는 분 발명의 분자를 전달시키기 위하여 이용될 수도 있다. 예컨대, 리보자임은 간으로 안티센스 놀리고누클레오티드의 국재화를 증가시키는 것으로 나타난 글리코실화된 폴리(L-리신)과 콘쥬게이션될 수 있다[참조: Nakazono et al., 1996, Hepatology 23, 1297-1303; Nahato et al., 1997, Biochem Pharm. 53, 887-895]. 글리코실화된 폴리(L-리신)은 효소적 핵산 분자와 공유적으로 결합하거나 정전기적 상호작용을 통하여 효소적 핵산과 결합될 수 있다.Other cationic molecules may also be used to deliver the molecules of the invention. For example, ribozymes may be conjugated with glycosylated poly (L-lysine), which has been shown to increase the localization of antisense teal and nucleotides into the liver (Nakazono et al., 1996, Hepatology 23, 1297-1303; Nahato et al., 1997, Biochem Pharm. 53, 887-895]. Glycosylated poly (L-lysine) may be covalently bound to enzymatic nucleic acid molecules or to enzymatic nucleic acids through electrostatic interactions.

본 발명은 약제학적으로 허용되는 담체 또는 희석제에 목적하는 화합물의 약학적 유효량을 포함하는 저장 또는 투여용으로 제조된 조성물도 포함한다. 치료적 용도로 허용되는 담체 또는 희석제는 약학 분야에서 잘 알려져 있고, 예컨대 본원에 참고문헌으로 삽입된 Remington's Pharmaceutical Sciences, Mack Publishing Co.(A.R. Gennaro edit. 1985)에 기술되어 있다. 예컨대, 보존제, 안정화제, 착색제 및 향료가 제공될 수 있다[Id. 1449]. 이들은 벤조산 나트륨, 소르브산 및 p-히드록시벤조산의 에스테르를 포함한다. 또한, 항산화제 및 현탁화제가 사용될 수 있다.The invention also includes compositions prepared for storage or administration comprising a pharmaceutically effective amount of the desired compound in a pharmaceutically acceptable carrier or diluent. Acceptable carriers or diluents for therapeutic use are well known in the pharmaceutical art and are described, for example, in Remington's Pharmaceutical Sciences, Mack Publishing Co. (A.R. Gennaro edit. 1985), incorporated herein by reference. For example, preservatives, stabilizers, colorants and perfumes may be provided [Id. 1449]. These include esters of sodium benzoate, sorbic acid and p-hydroxybenzoic acid. In addition, antioxidants and suspending agents may be used.

약학적 유효량은 질병 상태의 발생을 예방 및 억제하거나 치료(증상을 어느 정도, 바람직하게는 모두 완화)하는데 필요한 용량이다. 약학적 유효량은 질병의 유형, 사용된 조성물, 투여 경로, 치료받는 포유동물의 유형, 고려중인 특정 포유동물의 신체적 특성, 병용 약물, 및 의료 분야에서 당업자가 인지하는 기타 인자에 의존한다. 일반적으로, 음으로 하전된 중합체의 효능에 따라 활성 성분 1일 체중 kg당 0.1 내지 100mg의 양이 투여된다.A pharmaceutically effective amount is a dose necessary to prevent and inhibit the occurrence of a disease state or to treat (to some extent, preferably alleviate the symptoms). The pharmaceutically effective amount depends on the type of disease, the composition used, the route of administration, the type of mammal being treated, the physical characteristics of the particular mammal under consideration, the concomitant drug, and other factors recognized by those skilled in the medical arts. Generally, depending on the efficacy of the negatively charged polymer, an amount of 0.1 to 100 mg per kg body weight of the active ingredient is administered.

대안적으로, 본 발명의 효소적 핵산 분자는 진핵성 프로모터로부터 세포내에서 발현될 수 있다[예컨대 Izant and Weintraub, 1985 Science 229, 345; McGarry and Linquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA 88, 10591-5; Kashani-Sabet et a;., 1992 Antisense Res. Dev., 2, 2-15; Dropulic et al., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res.,23, 2259; Good et al., 1997, Gene Therapy, 4, 45; 상기 문헌 모두 전문이 본원에 참고문헌으로 삽입된다]. 당업자는 핵산이 적당한 DNA/RNA 벡터로부터 진핵 세포에서 발현될 수 있음을 알고 있다. 이러한 핵산의 활성은 리보자임에 의한 최초의 전사로부터 유리에 의해 증강될 수 있다[참조: Draper et al., PCT WO93/23569, and Sullivan et al., PCT WO94/02595; Ohkawa et al., 1992 Nucleic Acids Symp. Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856; 상기 문헌 모두 전문이 본원에 참고문헌으로 삽입된다].Alternatively, enzymatic nucleic acid molecules of the invention can be expressed intracellularly from eukaryotic promoters (eg, Izant and Weintraub, 1985 Science 229, 345; McGarry and Linquist, 1986 Proc. Natl. Acad. Sci. USA 83, 399; Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA 88, 10591-5; Kashani-Sabet et a;., 1992 Antisense Res. Dev., 2, 2-15; Dropulic et al., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65, 5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science 247, 1222-1225; Thompson et al., 1995 Nucleic Acids Res., 23, 2259; Good et al., 1997, Gene Therapy, 4, 45; All of which are incorporated herein by reference in their entirety. One skilled in the art knows that nucleic acids can be expressed in eukaryotic cells from suitable DNA / RNA vectors. The activity of such nucleic acids can be enhanced by free from the original transcription by ribozymes (Draper et al., PCT WO93 / 23569, and Sullivan et al., PCT WO94 / 02595; Ohkawa et al., 1992 Nucleic Acids Symp. Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30; Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55; Chowrira et al., 1994 J. Biol. Chem. 269, 25856; All of which are incorporated herein by reference in their entirety.

본 발명의 다른 측면에서, 표적 분자를 절단시키는 효소적 핵산 분자는 DNA 또는 RNA 벡터로 삽입된 전자 단위로부터 발현된다[참조: Couture et al., 1996, TIG., 12, 510]. 재조합 벡터는 바람직하게는 DNA 플라시미드 또는 바이러스 벡터이다. 리보자임 발현 바이러스 벡터는 아데노관련 바이러스, 레트로바이러스, 아데노바이러스, 또는 알파바이러스를 기재로 하여 작제될 수 있으나, 이에 한정되지 않는다. 바람직하게는, 리보자임을 발현할 수 있는 재조합 벡터는 상기한 바와 같이 전달되어 표적 세포에 잔존한다. 대안적으로, 바이러스 벡터는 리보자임의 일시적 발현을 위해 사용될 수 있다. 이러한 벡터는 필요에 따라 반복적으로 투여될 수 있다. 일단 발현되면, 리보자임은 표적 mRNA를 절단시킨다. 활성 리보자임은 예시된 것과 동등한 효소 중심 또는 코아를 함유하고, 결합 아암(arm)이 mRNA와 결합하여 표적 부위에서 절단이 일어나도록 할 수 있다. 이러한 절단을 방해하지 않는 기타 서열이 존재할 수 있다. 리보자임 발현 벡터의 전달은, 예컨대 정맥내 투여 또는 근육내 투여, 환자로부터 외식된 표적 세포로 투여후 환자에 재도입하거나 목적하는 표적 세포로 도입하기 위하여 허용되는 기타 수단에 의해 전신적으로 이루어질 수 있다[참조: Culture and Stinchcomb, 1996, TIG., 12, 510].In another aspect of the invention, an enzymatic nucleic acid molecule that cleaves a target molecule is expressed from an electronic unit inserted into a DNA or RNA vector (Couture et al., 1996, TIG., 12, 510). The recombinant vector is preferably a DNA plasmid or viral vector. Ribozyme expressing viral vectors can be constructed based on, but not limited to, adeno-associated viruses, retroviruses, adenoviruses, or alphaviruses. Preferably, recombinant vectors capable of expressing ribozymes are delivered as described above and remain in the target cell. Alternatively, viral vectors can be used for transient expression of ribozymes. Such vectors may be administered repeatedly as needed. Once expressed, ribozyme cleaves the target mRNA. Active ribozymes contain enzyme centers or cores equivalent to those exemplified, and the binding arm can bind the mRNA to cause cleavage at the target site. Other sequences may be present that do not interfere with such cleavage. Delivery of the ribozyme expression vector may be systemic, for example, by intravenous or intramuscular administration, by other means acceptable for reintroduction into the patient or introduction into the target cell of interest after administration to the explanted target cell. See Culture and Stinchcomb, 1996, TIG., 12, 510.

본 발명의 다른 측면에서, 본 발명의 하나 이상의 핵산 촉매를 엔코딩하는 핵산 서열을 포함하는 발현 벡터가 개시된다. 본 발명의 핵산 촉매를 엔코딩하는 핵산 서열은 핵산 분자의 발현을 허용하는 방식으로 작동적으로 결합된다.In another aspect of the invention, an expression vector comprising a nucleic acid sequence encoding one or more nucleic acid catalysts of the invention is disclosed. Nucleic acid sequences encoding nucleic acid catalysts of the invention are operably linked in a manner that allows expression of the nucleic acid molecule.

다른 측면에서, 본 발명은 하기를 포함하는 발현 벡터를 특징으로 한다; a)전사 개시 영역(예컨대, 진핵성 폴 Ⅰ,Ⅱ 또는 Ⅲ 개시 영역); b) 전사 종결 영역(예컨대, 진핵성 폴 Ⅰ,Ⅱ 또는 Ⅲ 종결 영역); c) 본 발명의 하나 이상의 핵산 촉매를 엔코딩하는 유전자; 및 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역 및 종결 영역과 작동적으로 결합된다. 벡터는 임의적으로 본 발명의 핵산 촉매를 엔코딩하는 유전자의 5' 측면 또는 3' 측면에 작동적으로 결합된 단백질에 대한 개방 해독 프레임(ORF); 및/또는 인트론(개재 서열)을 포함할 수 있다.In another aspect, the invention features an expression vector comprising; a) transcription initiation region (eg, eukaryotic pole I, II or III initiation region); b) transcription termination regions (eg, eukaryotic pole I, II or III termination regions); c) a gene encoding one or more nucleic acid catalysts of the invention; And the gene is operatively associated with the initiation and termination regions in a manner that allows expression and / or delivery of the nucleic acid molecule. The vector optionally comprises an open reading frame (ORF) for a protein operably linked to the 5 'side or 3' side of the gene encoding the nucleic acid catalyst of the invention; And / or introns (intervening sequences).

리보자임 서열의 전사는 진핵성 RNA 중합효소 Ⅰ(폴Ⅰ), RNA 중합효소Ⅱ (폴Ⅱ), 또는 RNA 중합효소 Ⅲ(폴Ⅲ)에 대한 프로모터로부터 유도된다. 폴Ⅱ 또는 폴 Ⅲ 프로모터로부터의 전사는 모든 세포에서 높은 수준으로 발현될 것이다; 주어진 세포 유형에서 주어진 폴 프로모터의 수준은 근처에 존재하는 유전자 조절 서열의 성질(증강서열, 침묵서열 등)에 의존할 것이다. 원핵성 RNA 중합효소가 적당한 세포에서 발현되는 경우, 원핵성 RNA 중합효소 프로모터도 사용된다[참조: Elroy-Stein and Moss, 1990 Proc. Natl. Acad. Sci. USA 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res.,21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37]. 몇몇 연구자들은 이러한 프로모터로부터 발현된 리보자임이 포유동물 세포에서 기능할 수 있는 것으로 설명하였다[예컨대, Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci. USA 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. USA 90, 8000-4; Thompson et al., 1995 Nucleic Acids Res.,23, 2259; Sullenger ＆ Cech, 1993, Science, 262, 1566]. 보다 상세하게는, U6 소핵(sn RNA), 운반 RNA(tRNA) 및 아데노바이러스 VA RNA를 엔코딩하는 유전자로부터 유도된 것과 같은 전사 단위는 세포에서 리보자임과 같은 고농도의 목적하는 RNA 분자를 생성시키는데 유용하다[Thomson et al., supra; Coutuer and Stinchcomb, 1996, supra; Noonberg et al., 1994, Nucleic Acids Res., 22, 2830; Noonberg et al., US Patent No. 5,624,803; Good et al., 1997, Gen Ther. 4, 45; Beigelman et al., International PCT Publication No. WO96/18736; 상기 간행물 모두 본원에서 참고문헌으로 삽입된다]. 상기 리보자임 전사 단위는 플라스미드 DNA 벡터, 바이러스 DNA 벡터(예컨대, 아데노바이러스 또는 아데노관련 바이러스 벡터), 또는 바이러스 RNA 벡터(예컨대, 레트로바이러스 또는 알파바이러스 벡터)를 포함하지만, 이에 한정되지 않는, 포유동물 세포로의 도입을 위한 다양한 벡터로 혼입될 수 있다[참조: Couture and Stinchcomb, 1996, supra].Transcription of ribozyme sequences is derived from promoters for eukaryotic RNA polymerase I (pol I), RNA polymerase II (pol II), or RNA polymerase III (pol III). Transcription from the Pol II or Pol III promoters will be expressed at high levels in all cells; The level of a given pole promoter in a given cell type will depend on the nature of the gene control sequences present nearby (amplification sequences, silent sequences, etc.). If a prokaryotic RNA polymerase is expressed in a suitable cell, a prokaryotic RNA polymerase promoter is also used. Elroy-Stein and Moss, 1990 Proc. Natl. Acad. Sci. USA 87, 6743-7; Gao and Huang 1993 Nucleic Acids Res., 21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66; Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37. Some researchers have demonstrated that ribozymes expressed from such promoters can function in mammalian cells (eg, Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chen et al., 1992 Nucleic Acids Res 20, 4581-9; Yu et al., 1993 Proc. Natl. Acad. Sci. USA 90, 6340-4; L'Huillier et al., 1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. Natl. Acad. Sci. USA 90, 8000-4; Thompson et al., 1995 Nucleic Acids Res., 23, 2259; Sullenger & Cech, 1993, Science, 262, 1566]. More specifically, transcriptional units such as those derived from genes encoding U6 micronucleus (sn RNA), carrier RNA (tRNA) and adenovirus VA RNA are useful for producing high concentrations of desired RNA molecules such as ribozymes in cells. Thomson et al., Supra; Coutuer and Stinchcomb, 1996, supra; Noonberg et al., 1994, Nucleic Acids Res., 22, 2830; Noonberg et al., US Patent No. 5,624,803; Good et al., 1997, Gen Ther. 4, 45; Beigelman et al., International PCT Publication No. WO96 / 18736; All of these publications are incorporated herein by reference. The ribozyme transcription unit includes, but is not limited to, a plasmid DNA vector, a viral DNA vector (eg, adenovirus or adeno-associated virus vector), or a viral RNA vector (eg, retrovirus or alphavirus vector). It can be incorporated into a variety of vectors for introduction into cells (Couture and Stinchcomb, 1996, supra).

또다른 측면에서, 본 발명은 핵산 분자의 발현을 허용하는 방식으로, 본 발명의 하나 이상의 촉매적 핵산 분자를 엔코딩하는 핵산 서열을 포함하는 발현 벡터를 특징으로 한다. 발현 벡터는 한 구현예에서 a) 전사 개시 영역; b) 전사 종결 영역; c) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 다른 바람직한 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 개방 해독 프레임; d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 개방 해독 프레임의 3' 말단과 작동적으로 결합하고 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 개방 해독 프레임 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 또다른 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 인트론; d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 인트론 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다. 다른 구현예에서, 발현 벡터는 a) 전사 개시 영역; b) 전사 종결 영역; c) 인트론; d) 개방 해독 프레임; e) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하고, 상기 유전자는 개방 해독 프레임의 3' 말단과 작동적으로 결합하고 상기 핵산 분자의 발현 및/또는 전달을 허용하는 방식으로 개시 영역, 인트론, 개방 해독 프레임 및 종결 영역과 작동적으로 결합하는 것을 특징으로 한다.In another aspect, the invention features an expression vector comprising a nucleic acid sequence encoding one or more catalytic nucleic acid molecules of the invention in a manner that allows expression of the nucleic acid molecule. The expression vector is in one embodiment a) a transcription initiation region; b) transcription termination region; c) a gene encoding at least one nucleic acid molecule, said gene being operatively bound to the initiation and termination regions in a manner that allows expression and / or delivery of said nucleic acid molecule. In another preferred embodiment, the expression vector comprises a) a transcription initiation region; b) transcription termination region; c) an open reading frame; d) a gene encoding one or more nucleic acid molecules, said gene operatively binding to the 3 'end of the open translation frame and initiating region, open translation frame in a manner that allows expression and / or delivery of said nucleic acid molecule And operatively coupled to the termination region. In another embodiment, the expression vector comprises a) a transcription initiation region; b) transcription termination region; c) introns; d) a gene encoding at least one nucleic acid molecule, said gene being operatively bound to the initiation region, intron and termination region in a manner that allows expression and / or delivery of said nucleic acid molecule. In other embodiments, the expression vector comprises a) a transcription initiation region; b) transcription termination region; c) introns; d) an open reading frame; e) a gene encoding one or more nucleic acid molecules, said gene operably binding to the 3 'end of an open reading frame and initiating region, intron, opening in a manner that allows expression and / or delivery of said nucleic acid molecule And operatively coupled to the decryption frame and the termination region.

인터페론Interferon

타입 Ⅰ 인터페론(IFN)은 25개를 초과하는 IFN-α과[Pesta, 1986, Methods Enzymol. 119, 3-14] 뿐만 아니라 IFN-β, 및 IFN-ω를 포함한 천연의 사이토카인의 일종이다. 동일한 유전자로부터 진화론적으로 유도되었지만[Diaz et al., 1994, Genomics 22, 540-552], 이들 분자의 1차 서열에는 많은 차이점이 있으며, 이는 생물학적 활성에서 진화론적 다양성을 암시한다. 모든 타입 Ⅰ IFN은 IFN의 세포 표면 수용체 결합으로 시작하는 공통적인 페턴의 생물학적 효과를 공유한다[참조: Pfeffer ＆ Strulovici, 1992, Transmembrane secondary messengers for IFN-α/β, In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds 151-160). 결합후에 재너스(Janus) 티로신 키나제 및 STAT 단백질을 포함한 티로신 키나제가 활성화되어, 수개의 IFN-자극된 유전자 산물의 생성을 초래한다[참조: Johnson et al., 1994, Sci. Am. 270, 68-75]. IFN-자극된 유전자 산물은 항바이러스 효과, 항증식 효과, 및 면역조절 효과를 포함한 타입 Ⅰ IFN의 다면성(pleotropic) 생물학적 효과의 원인이 된다[참조: Pestka et al., 1987, Annu. Rev. Biochem. 56, 727]. IFN-자극된 유전자 산물의 예는 2-5-올리고아데닐레이트 합성효소(2-5 OAS), β2-마이크로글로불린, 네오프테린, p68 키나제, 및 Mx 단백질을 포함한다[참조: Chebath ＆ Revel, 1992, The 2-5 A system: 2-5 A synthetase, isospecies and functions. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 225-236; Samuel 1992, The RNA-dependent P1/eIF-2α protein kinase. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 237-250; Horisberger, 1992, MX protein: function and Mechanism of Action In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 215-224]. 모든 타입 Ⅰ IFN이 유사한 생물학적 효과를 가지고 있지만, 각 타입 Ⅰ IFN이 모든 활성을 공유하는 것은 아니며, 많은 경우에 활성의 정도는 각 IFN 서브타입에 대하여 실질적으로 상당히 변화한다[참조: Fish et al., 1989, J. Interferon Res. 9, 97-114; Ozes et al., 1992, J. Interferon Res 12, 55-59]. 보다 상세하게는, 상이한 서브타입의 IFN-α의 성질 및 IFN-α의 분자 하이브리드는 약리학적 성질에서 차이를 나타내었다[참조: Rubinstein, 1987, J. Interferon Res. 7, 545-551]. 이러한 약리학적 차이는 3개의 아미노산 잔기 변화에 기인하는 것일 수 있다[Lee et al., 1982, Cancer Res. 42, 1312-1316].Type I interferon (IFN) has more than 25 IFN-α and [Pesta, 1986, Methods Enzymol. 119, 3-14] as well as natural cytokines, including IFN-β and IFN-ω. Although evolutionarily derived from the same gene (Diaz et al., 1994, Genomics 22, 540-552), there are many differences in the primary sequences of these molecules, suggesting evolutionary diversity in biological activity. All Type I IFNs share a common pattern of biological effects, starting with cell surface receptor binding of IFNs (Pfeffer & Strulovici, 1992, Transmembrane secondary messengers for IFN-α / β, In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds 151-160). After binding, tyrosine kinases, including Janus tyrosine kinases and STAT proteins, are activated, resulting in the production of several IFN-stimulated gene products. Johnson et al., 1994, Sci. Am. 270, 68-75]. IFN-stimulated gene products contribute to the pleotropic biological effects of Type I IFN, including antiviral, antiproliferative, and immunomodulatory effects (Pestka et al., 1987, Annu. Rev. Biochem. 56, 727]. Examples of IFN-stimulated gene products include 2-5-oligoadenylate synthetase (2-5 OAS), β2-microglobulin, neopreterin, p68 kinase, and Mx protein. Chebath & Revel , 1992, The 2-5 A system: 2-5 A synthetase, isospecies and functions. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 225-236; Samuel 1992, The RNA-dependent P1 / eIF-2α protein kinase. In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 237-250; Horisberger, 1992, MX protein: function and Mechanism of Action In: Interferon. Principles and Medical Applications, S. Baron, D. H. Coopenhaver, F. Dianzani, W. R. Fleischmann Jr., T.K. Hughed Jr., G.R. Kimpel, D. W. Niesel, G.J. Stanton, and S.K. Tyring, eds pp 215-224. Although all Type I IFNs have similar biological effects, not all Type I IFNs share all activity, and in many cases the degree of activity varies substantially substantially for each IFN subtype. Fish et al. , 1989, J. Interferon Res. 9, 97-114; Ozes et al., 1992, J. Interferon Res 12, 55-59. More specifically, the properties of IFN-α of different subtypes and molecular hybrids of IFN-α showed differences in pharmacological properties. Rubinstein, 1987, J. Interferon Res. 7, 545-551. Such pharmacological differences may be due to three amino acid residue changes [Lee et al., 1982, Cancer Res. 42, 1312-1316.

85 내지 166개 아미노산이 공지된 IFN-α에서 보존된다. IFN-α 유사유전자를 제외하면, 약 25개의 공지된 상이한 IFN-α 서브타입이 있다. 이러한 비대립유전자 서브타입을 쌍끼리 비교하면 2 내지 23% 범위의 1차 서열의 차이를 나타낸다. 천연 IFN에 부가하여, 컨센서스 인터페론(CIFN)으로 공지된 천연 재조합 타입 Ⅰ 인터페론은 치료 화합물로서 합성되었다{참조: Tong et al., 1997, Hepatology 26, 747-754].85 to 166 amino acids are conserved in known IFN-α. Except for the IFN-α pseudogenes, there are about 25 known different IFN-α subtypes. Comparison of these non-allele subtypes between pairs shows differences in primary sequences ranging from 2 to 23%. In addition to native IFN, native recombinant Type I interferon known as consensus interferon (CIFN) has been synthesized as a therapeutic compound (Tong et al., 1997, Hepatology 26, 747-754).

인터페론은 현재 감염성 질환 및 자가면역 질환 및 암을 포함한 12개 이상의 상이한 적응증에 대하여 사용된다[참조: Borden, 1992, N. Engl. J. Med. 326, 1491-1492]. 자가면역 질환에 대하여, IFN은 류마티스성 관절염, 다발성 경화증, 및 크론병의 치료에 사용되어 왔다. 암 치료에 대하여, IFN은 단독으로 또는 많은 상이한 화합물과 병용하여 사용되어 왔다. IFN이 사용되었던 특정 유형의 암은 편평상피 암종, 흑색종, 부신종, 혈관종, 모양세포성 백혈병, 및 카포시 육종을 포함한다. 감염성 질환의 치료에 있어서, IFN은 마크로파지의 식세포 활성 및 림프구의 세포독성을 증가시키고 세포성 병원체의 전파를 저해한다. IFN이 치료제로서 사용된 특정 적응증은 B형 간염, 인간 유두종바이러스 타입 6 및 11(즉, 생식기 사마귀)[참조: Leventhal et al., 1991, N. Engl. J. Med. 325, 613-617], 만성 과립구성 질환, 및 C형 바이러스성 간염을 포함한다.Interferon is currently used for at least 12 different indications, including infectious diseases and autoimmune diseases and cancer. Borden, 1992, N. Engl. J. Med. 326, 1491-1492. For autoimmune diseases, IFN has been used to treat rheumatoid arthritis, multiple sclerosis, and Crohn's disease. For the treatment of cancer, IFN has been used either alone or in combination with many different compounds. Certain types of cancer in which IFN has been used include squamous carcinoma, melanoma, adrenal gland, hemangioma, hematopoietic leukemia, and Kaposi's sarcoma. In the treatment of infectious diseases, IFN increases the phagocytic activity of macrophages and cytotoxicity of lymphocytes and inhibits the spread of cellular pathogens. Specific indications in which IFN is used as a therapeutic agent include hepatitis B, human papillomavirus types 6 and 11 (ie genital warts) [Leventhal et al., 1991, N. Engl. J. Med. 325, 613-617, chronic granulocytic disease, and viral hepatitis C.

만성 HCV 감염의 치료에서 IFN-α를 사용한 많은 대조 임상 시험결과는 주 3회 치료로 6개월의 치료기간이 끝났을 때 환자의 약 50%에서 혈청 ALT 수치가 감소됨이 증명되었다[참조: Davis et al., 1989, The New England Journal of Medicine 321, 1501-1506; Marcellin et al., 1991, Hepatology 13, 393-397; Tong et al., 1997, Hepatology 26 747-754; Tong et al., Hepatology 26 1640-1645]. 그러나, 인터페론 치료의 중지후에, 반응한 환자의 약 50%가 재발한 결과, 혈청 ALT 농도의 정상화로 평가한 "영구" 반응율은 약 20 내지 25%였다. 또한, 임상적 종말점으로서 HCV RNA 수치의 변화를 사용한 타입 1 인터페론 요법을 6개월간 조사한 연구에서 환자의 35% 이하가 치료의 종료시에 HCV RNA가 소실되는 것으로 나타났다[참조: Tong et al., 1997, supra]. 그러나, ALT 종말점에서와 같이, 약 50%의 환자가 치료 중지후 6개월에 재발한 결과 영구적 바이러스학적 반응은 단지 12%에 불과하였다(23). 48주 요법을 시험한 염구에서는 유지된 바이러스학적 반응은 25% 이하인 것으로 나타났다.Many control trials using IFN-α in the treatment of chronic HCV infection demonstrated reduced serum ALT levels in about 50% of patients at the end of the 6-month treatment period with three weekly treatments. Davis et al. , 1989, The New England Journal of Medicine 321, 1501-1506; Marcellin et al., 1991, Hepatology 13, 393-397; Tong et al., 1997, Hepatology 26 747-754; Tong et al., Hepatology 26 1640-1645. However, after discontinuation of interferon treatment, about 50% of the responding patients relapsed and the “permanent” response rate, as assessed by normalization of serum ALT concentration, was about 20-25%. In addition, a six-month study of Type 1 interferon therapy using changes in HCV RNA levels as a clinical endpoint showed that up to 35% of patients lost HCV RNA at the end of treatment [Tong et al., 1997, supra]. However, as at the ALT endpoint, about 50% of patients recurred 6 months after discontinuation of treatment, resulting in only a 12% permanent virological response (23). In the 48 weeks of treatment, the sustained virological response was found to be less than 25%.

IFN과 병용한 리보자임은 HCV 또는 상기한 기타 어느 적응증의 치료 유효성을 개선시킬 가능성이 있다. 감염성 질환, 자가면역질환, 및 암과 같은 질환과 관련된 RNA를 표적화하는 리보자임은 단독으로 또는 증가된 효능을 얻기 위하여 IFN과 같은 기타 요법과 병용하여 사용될 수 있다.Ribozymes in combination with IFN are likely to improve the therapeutic effectiveness of HCV or any of the other indications described above. Ribozymes that target RNA associated with diseases such as infectious diseases, autoimmune diseases, and cancer can be used alone or in combination with other therapies such as IFN to obtain increased efficacy.

실시예Example

다음은 본 발명의 효소적 핵산의 선택, 분리, 합성 및 활성을 나타내는 비한정적 실시예이다.The following is a non-limiting example showing the selection, isolation, synthesis and activity of the enzymatic nucleic acid of the present invention.

하기 실시예는 HCV RNA를 절단시키는 리보자임의 선택성을 나타낸다. 본원에 기술된 방법은 HCV 복제에 필요한 기타 RNA 표적을 절단시키는 리보자임이 유도되는 설계를 나타낸다.The following examples show the selectivity of ribozymes for cleaving HCV RNA. The methods described herein represent designs in which ribozymes are induced to cleave other RNA targets required for HCV replication.

실시예 1: HCV RNA에서 유효 리보자임의 확인Example 1 Identification of Effective Ribozymes in HCV RNA

HCV RNA의 서열을 컴퓨터 폴딩 알고리즘을 사용하여 접근 가능 부위를 스크리닝하였다. 2차 폴딩 구조를 형성하지 않으며 유효 해머헤드 및/또는 헤어핀 리보자임 분해 부위를 함유하지 않는 mRNA 영역을 확인하였다. 이러한 분해 부위의 서열이 표 IV-VIII에 기재되어 있다.Sequences of HCV RNA were screened for accessible sites using computer folding algorithms. MRNA regions that did not form a secondary folding structure and did not contain an effective hammerhead and / or hairpin ribozyme degradation site were identified. The sequences of these degradation sites are described in Table IV-VIII.

실시예 2: HCV RNA에서 리보자임 절단 부위의 선택Example 2: Selection of Ribozyme Cleavage Sites in HCV RNA

컴퓨터 사용 RNA 폴딩 알고리즘에 의해 예상된 부위가 HCV RNA의 접근 가능 부위에 상응하는 지를 시험하기 위해, 20개의 해머헤드 부위를 분석용으로 선택하였다. 리보자임 표적 부위는 HCV의 게놈 서열(도입 서열 = HPCJTA(Acc#D11168 ＆ D01171))을 분석하고, 폴딩을 기초로 하여 상기 부위를 우선 순위로 하므로써 선택하였다. 해머헤드 리보자임은 각각의 표적물을 결합시킬 수 있도록(도 1 참조) 구성되었으며, 리보자임 서열이 적합한 2차 구조로 폴딩되었는지를 평가하기 위해 컴퓨터 폴딩(Chritoffersen et al., 1994 J. Mol. Struc. Theochem, 311, 273; Jaeger et al., 1989, Proc. Natl. Acad. Sci. USA, 86, 7706)에 의해 개별적으로 분석하였다. 결합 아암과 촉매적 코아간의 바람직하지 않은 분자내 상호작용을 갖는 리보자임은 고려 대상에서 탈락시켰다. 하기 기재되는 바와 같이, 활성을 최적화시키기 위해 결합 아암의 길이를 달리하여 선택할 수 있다. 일반적으로, 각 아암상에 5개 이상의 염기가 표적 RNA 결합할 수 있거나, 다르게는 표적 RNA와 상호작용한다.Twenty hammerhead sites were selected for analysis to test whether the sites expected by the computer-assisted RNA folding algorithm correspond to accessible sites of the HCV RNA. Ribozyme target sites were selected by analyzing the genomic sequence of HCV (introduction sequence = HPCJTA (Acc # D11168 & D01171)) and prioritizing the site based on folding. Hammerhead ribozymes were configured to bind each target (see FIG. 1), and computerized (Chritoffersen et al., 1994 J. Mol. Struc. Theochem, 311, 273; Jaeger et al., 1989, Proc. Natl. Acad. Sci. USA, 86, 7706). Ribozymes with undesirable intramolecular interactions between the binding arm and the catalytic core were dropped from consideration. As described below, the length of the binding arm can be selected to optimize the activity. In general, at least 5 bases on each arm can bind to the target RNA or otherwise interact with the target RNA.

리보자임 후보의 선택은 HCV 제노타입 1b에 감염된 환자로부터 유도된 HCV RNA 서열에서 모든 해머헤드 분해 부위를 스캐닝하므로써 개시하였다. 이 서열 분석 결과는 표 III에 기재된다. 표 III으로 알 수 있는 바와 같이, 상기 분석으로 1300개의 해머헤드 리보자임 부위가 확인되었다. 다음으로, HCV 게놈의 보존된 영역에서 절단될 수 있는 해머헤드 리보자임 후보를 확인하기 위해, 제노타입, 1a, 1b, 2a, 2b, 3a, 3b, 4a, 5a 및 6으로부터의 대략 50개의 HCV 단리물의 서열 배열을 완료하였다. 제노타입내에서 부위는 조사된 모든 단리물 간에 가장 큰 서열 동일성을 갖는 영역에 존재하는 것으로 확인되었다. 이러한 분석은 해머헤드 리보자임 후보를 약 23개로 감소시켰다(표 III).The selection of ribozyme candidates was initiated by scanning all hammerhead degradation sites in HCV RNA sequences derived from patients infected with HCV genotype 1b. The results of this sequence analysis are shown in Table III. As can be seen from Table III, this analysis identified 1300 hammerhead ribozyme sites. Next, approximately 50 HCVs from genotypes, 1a, 1b, 2a, 2b, 3a, 3b, 4a, 5a, and 6 to identify candidates for hammerhead ribozymes that can be cleaved in conserved regions of the HCV genome. The sequence alignment of the isolates was completed. Sites within the genotype were identified as present in the region with the largest sequence identity between all the isolates investigated. This analysis reduced the hammerhead ribozyme candidates to about 23 (Table III).

HCV 게놈의 높은 서열 변이성으로 인해, 광범위한 치료 적용을 위한 리보자임의 선택은 HCV 게놈의 보존된 영역을 포함해야 할 것이다. HCV 게놈의 보존된 영역(5'-비코딩 영역(NCR), 5'-코아 단백질 코딩 영역의 말단, 및 3'-NCR)으로부터의 30개 해머헤드 리보자임의 리스트가 표 IV에 기재되어 있다. 일반적으로, HCV 게놈의 5' 말단 영역에 위치한 부위로 표적되는 리보자임은 번역을 차단해야 하고, 게놈의 3' 말단 영역에 위한 리보자임 절단 부위는 RNA 복제를 차단해야 한다.Due to the high sequence variability of the HCV genome, the selection of ribozymes for a wide range of therapeutic applications will have to include conserved regions of the HCV genome. A list of 30 hammerhead ribozymes from conserved regions of the HCV genome (5'-noncoding region (NCR), end of 5'-core protein coding region, and 3'-NCR) is listed in Table IV. . In general, ribozymes targeted to sites located at the 5 'end region of the HCV genome should block translation, and ribozyme cleavage sites for the 3' end region of the genome should block RNA replication.

실시예 3 : 리보자임의 화학적 합성 및 정제Example 3 Chemical Synthesis and Purification of Ribozyme

해머헤드 또는 헤어핀 모티프의 리보자임을 RNA 메시지의 다양한 부위에 아닐링하도록 설계하였다. 결합되는 아암(arm)은 상기된 표적 부위 서열에 상보적이다. 그런 다음, 리보자임을 화학적으로 합성하였다. 사용된 합성 방법은 우스만(Usman) 등의 문헌[1987 J. Am. Chem. Soc., 109, 7845], 스카린지(Scaringe) 등의 문헌[1990 Nucleic Acids Res., 18, 5433] 및 윈코트(Wincott) 등의 문헌(상기)에 기술된 RNA 합성 방법을 따랐으며, 5'-말단에서 디메톡시트리틸 및 3'-말단에서 포스포르아미다이트와 같은 보통의 핵산 보호 및 커플링 그룹을 사용하였다. 평균적인 단계식 커플링 수율은 ＞98% 이었다.Ribozymes of hammerhead or hairpin motifs were designed to anneal to various sites in the RNA message. The arm to be joined is complementary to the target site sequence described above. Then, ribozyme was chemically synthesized. Synthetic methods used are described in Usman et al., 1987 J. Am. Chem. Soc., 109, 7845, Scaringe et al. (1990 Nucleic Acids Res., 18, 5433) and Wincott et al. (Supra) followed the RNA synthesis methods described, Normal nucleic acid protection and coupling groups such as dimethoxytrityl at the end and phosphoramidite at the 3'-end were used. The average step coupling yield was> 98%.

G5A6의 순서를 바꾸고 A14대신에 U를 사용함으로써 불활성의 해머헤드 리보자임을 합성하였다(이러한 번호매김은 문헌[Hertel et al., 1992 Nucleic Acids Res., 20, 3252]을 참조). 헤어핀 리보자임을 2개 부분으로 합성하고 아닐링하여 활성 리보자임을 재구성하였다[참고문헌: Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840]. 박테리오파아지 T7 RNA 폴리머라아제를 사용하여 DNA 템플레이트로부터도 리보자임을 합성하였다[참고문헌: Milligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51]. 누클레아제 저항성 그룹, 예를 들어, 2'-아미노, 2'-C-알릴, 2'-플루오로, 2'-O-메틸, 2'-H에 의한 개질에 의해 안정도를 증대시키기 위해 리보자임을 개질시켰다[참고문헌: Usman and Cedergren, 1992 TIBS 17, 34]. 리보자임을 일반적인 방법을 사용하여 겔 전기영동법에 의해 정제하고 고압 액체 크로마토그래피 (HPLC: 본원에 참고문헌으로 인용된 윈코트 등의 문헌(상기) 참조)에 의해 정제하고 수중에 재현탁시켰다. 본 연구에서 사용된 화학적으로 합성된 리보자임의 서열은 하기 표 4-9에 수록되어 있다.An inert hammerhead ribozyme was synthesized by reversing the order of G 5 A 6 and using U instead of A 14 (see Hertel et al., 1992 Nucleic Acids Res., 20, 3252). . Hairpin ribozyme was synthesized in two parts and annealed to reconstitute the active ribozyme (Ref. Chowrira and Burke, 1992 Nucleic Acids Res., 20, 2835-2840). Ribozymes were also synthesized from DNA templates using bacteriophage T7 RNA polymerases (Milligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51]. Lio to increase stability by modification with nuclease resistant groups such as 2'-amino, 2'-C-allyl, 2'-fluoro, 2'-0-methyl, 2'-H Bozaim was modified (Ref. Usman and Cedergren, 1992 TIBS 17, 34). Ribozyme was purified by gel electrophoresis using conventional methods, purified by high pressure liquid chromatography (HPLC: see Wincoat et al., Supra), and resuspended in water. The chemically synthesized ribozyme sequences used in this study are listed in Tables 4-9 below.

실시예 4 : 시험관내에서의 HCV RNA 표적의 리보자임 분열Example 4 Ribozyme Cleavage of HCV RNA Targets in Vitro

HCV를 대상으로 한 리보자임을 상기한 바와 같이 설계하고 합성하였다. 이들 리보자임을, 예를 들어 다음 과정을 사용하여 시험관내 분열 활성에 대해 시험하였다. HCV내에서의 표적 서열 및 누클레오티드 위치는 표 4에 기재하였다.Ribozymes for HCV were designed and synthesized as described above. These ribozymes were tested for in vitro cleavage activity using the following procedure, for example. Target sequences and nucleotide positions within HCV are listed in Table 4.

분열 반응 : 리보자임 분열 검정을 위해 온길이 또는 부분 온길이, 내부 표지된 표적 RNA를 [α-32P]CTP의 존재하에 시험관내 전사에 의해 제조하고 스핀 크로마토그래피에 의해 G 50 세파덱스 칼럼을 통과시키고 추가의 정제 없이 기질 RNA로서 사용하였다. 대안적으로, 기질을 T4 폴리누클레오티드 키나아제 효소를 사용하여 5'-32P 말단 표지시켰다.Cleavage reaction: Full or partial warm, internally labeled target RNA for ribozyme cleavage assays was prepared by in vitro transcription in the presence of [α- 32 P] CTP and G 50 Sephadex column by spin chromatography. Passed and used as substrate RNA without further purification. Alternatively, substrates were 5'- 32 P end labeled using T4 polynucleotide kinase enzyme.

검정은 리보자임 절단 완충액(50 mM Tris-HCl, 37℃에서 pH 7.5, 10 mM MgCl2)중의 미리 데워진 2X 농도의 정제된 리보자임에 의해 수행하였으며 역시 미리 데워진 절단 완충액중에 있는 동일 부피의 기질 RNA(최대 1-5 nM)에 2X 리보자임 혼합물을 첨가함으로써 절단 반응을 개시시켰다. 초기 스크리닝과 같이, 검정을 최종 농도가 40 nM 또는 1 mM인 리보자임, 즉, 리보자임 초과량을 사용하여 37℃에서 1시간 동안 수행하였다. 샘플을 2분 동안 95℃로 가열시키고, 급냉시켜 변성 폴리아크릴아미드 겔에 로딩시킨 후에 동일 부피의 95% 포름아미드, 20 mM EDTA, 0.05% 브로모페놀 블루 및 0.05% 자일렌 시아놀을 첨가함으로써 켄칭시켰다. 리보자임 절단에 의해 생성된 기질 RNA 및 특이적인 RNA 절단 산물을 겔의 자동방사능사진상에 가시화시켰다. 절단 %를 본래 기질 및 절단 산물을 나타내는 밴드들의 포스포 이지저(Phosphor Imager: 등록상표) 정량에 의해 결정하였다.The assay was performed by prewarmed 2X concentration of purified ribozyme in ribozyme cleavage buffer (50 mM Tris-HCl, pH 7.5 at 37 ° C., 10 mM MgCl 2 ) and also in the same volume of substrate RNA in the prewarmed cleavage buffer The cleavage reaction was initiated by adding 2X ribozyme mixture to (maximum 1-5 nM). As with initial screening, the assay was performed at 37 ° C. for 1 hour using ribozyme, ie, excess ribozyme, with a final concentration of 40 nM or 1 mM. The sample was heated to 95 ° C. for 2 minutes, quenched and loaded into a modified polyacrylamide gel, followed by the addition of equal volume of 95% formamide, 20 mM EDTA, 0.05% bromophenol blue and 0.05% xylene cyanol. Quenched. Substrate RNA and specific RNA cleavage products generated by ribozyme cleavage were visualized on autoradiographs of the gel. % Cleavage was determined by Phosphor Imager® quantification of the bands representing the original substrate and cleavage product.

실시예 5: 환자 혈청에서 HCV RNA를 절단하는 HCV 리보자임의 능력.Example 5: The ability of HCV ribozymes to cleave HCV RNA in patient serum.

HCV RNA에서 리보자임 표적 부위를 핵산가수분해효소 저항성을 부여하는 개질을 사용하여 합성하였다[참조 : Beigelman, 1995, J. Biol. Chem. 270, 25702). 만성 C형 간염 환자로부터의 혈청이 평균 3 x 106copies/ml의 HCV RNA를 보유하고 있다는 것은 널리 알려져 있다. 리보자임 생산 후보물질을 추가로 선택하기 위해, 30 HCV 특이적 리보자임을 인자형 1b HCV 환자의 혈청으로부터 분리된 HCV RNA를 사용하여 HCV RNA 절단 활성에 대해 특징화하였다. HCV 인자형 1b 스크리닝으로부터의 가장 좋은 후보물질이 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a 및 6를 포함하는 HCV 인자형의 광위로부터의 분리체에 대해 스크리닝될 것이다. 그러므로, 다양한 범위의 HCV 인자형 및 유사종으로부터의 HCV RNA를 대체로 절단하는 이들의 능력에 기초한 추가 개발을 위해 리보자임 후보물질을 선택하는 것이 가능하다.Ribozyme target sites in HCV RNA were synthesized using modifications conferring nucleic acid hydrolase resistance. Beigelman, 1995, J. Biol. Chem. 270, 25702). It is well known that serum from patients with chronic hepatitis C has an average of 3 × 10 6 copies / ml of HCV RNA. To further select ribozyme production candidates, 30 HCV specific ribozymes were characterized for HCV RNA cleavage activity using HCV RNA isolated from the sera of genotype 1b HCV patients. The best candidates from HCV genotype 1b screening will be screened for isolates from the wide range of HCV genotypes including 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 5a and 6. Therefore, it is possible to select ribozyme candidates for further development based on their ability to generally cleave HCV RNA from a wide range of HCV genotypes and similar species.

실시예 6: 시험관내에서 보존된 HCV RNA 표적 부위의 리보자임 절단Example 6: Ribozyme Cleavage of HCV RNA Target Sites Conserved in Vitro

하나의 인자형 내에서 및 다른 인자형들에 걸쳐 고도로 보존되어 있는 게놈의 3 영역이 있다. 이들 보존 서열들은 5' 및 3' 코딩되지 않는 영역(NCR) 뿐만 아니라 코어 단백질 코딩 영역의 5'말단에 나타난다. 이 영역들은 HCV RNA 복제 및 번역을 위해 중요하다고 생각된다. 따라서, 이들 보존된 HCV 게놈 영역들을 표적으로 하는 치료제들은 넓은 범위의 HCV 인자형에 걸쳐 현저한 효과를 가질 수 있다. 유사종의 존재 및 하나 이상의 인자형에 의한 감염에 대한 가능성은 이것이 효과적인 치료의 중요한 특성이 되도록 하였다. 또한, 약물 내성을 유발시키는 것으로 제안되고 있는 돌연변이들은 전형적으로 이렇게 고도로 보존된 영역들내에서 발생하지 않기 때문에 약물 내성이 발생할 것 같지 않다. 다수의 유전자형을 표적화시키고 발달하는 약물 내성의 변화를 감소시키기 위해, 본 출원인은 앞서 언급된 보존 영역내의 동일 영역중에서 분할되는 리보자임을 고안하였다.There are three regions of the genome that are highly conserved within one genotype and across other genotypes. These conserved sequences appear at the 5 'end of the core protein coding region as well as the 5' and 3 'uncoded regions (NCR). These regions are considered important for HCV RNA replication and translation. Thus, therapeutic agents targeting these conserved HCV genomic regions can have significant effects over a wide range of HCV genotypes. The presence of similar species and the potential for infection by one or more genotypes has made this an important characteristic of effective treatment. In addition, it is unlikely that drug resistance will occur because mutations that have been proposed to induce drug resistance typically do not occur in these highly conserved regions. To target multiple genotypes and reduce changes in drug resistance that develop, we have designed ribozymes that are divided among the same regions within the conserved regions mentioned above.

서열을 5' NCR, 코어 단백질 코딩 영역의 5' 단부 및 3'NCR에 대해서 정렬시켰다. 5' NCR에 있어서, 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4f 및 5a를 나타내는 34개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 기준 번호로서 보고된 서열 "HPCK1S1"을 사용하여, 누클레오티드 위치 1에서부터 누클레오티드 위치 350(개시인자 ATG 코돈 아래쪽의 18개의 누클레오티드)까지의 서열을 포함하였다. 코어 단백질 코딩 영역에 있어서, 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4c, 4f, 5a 및 6a를 나타내는 44개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 개시인자 ATG 코돈 앞쪽의 8개의 누클레오티드로부터 시작하여, 600개의 누클레오티드를 포함하였다. 기준 번호로서, 보고된 서열 "HPCCOPR"을 사용하였으며, 개시인자 코돈 ATG 앞쪽의 8개의 "C" 누클레오티드를 "1"로 지정하였다. 3' NCR 영역에 있어서, 유전자형 1b, 2a, 2b, 3a 및 3b를 나타내는 20개의 상이한 단리물을 정렬시켰다. 이러한 정렬은 게놈의 3' 말단 235개의 누클레오티드중의 서열을 포함하였고, 보고된 서열 "D85516"을 기준 번호로서 사용하였으며, 3' 단부로부터의 235번째 누클레오티드를 "1"로 지정하였다.The sequence was aligned with respect to the 5 'NCR, the 5' end of the core protein coding region and the 3'NCR. For 5 'NCR, 34 different isolates representing 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4f and 5a were aligned. This alignment included sequences from nucleotide position 1 to nucleotide position 350 (18 nucleotides below the initiator ATG codon) using the sequence “HPCK1S1” reported as reference number. For the core protein coding region, 44 different isolates representing 1a, 1b, 2a, 2b, 2c, 3a, 3b, 4a, 4c, 4f, 5a and 6a were aligned. This alignment included 600 nucleotides, starting with 8 nucleotides in front of the initiator ATG codon. As reference number, the reported sequence "HPCCOPR" was used and the eight "C" nucleotides preceding the initiator codon ATG were designated as "1". In the 3 ′ NCR region, 20 different isolates showing genotypes 1b, 2a, 2b, 3a and 3b were aligned. This alignment included the sequence among the 235 nucleotides at the 3 'end of the genome, using the reported sequence "D85516" as the reference number and designating the 235th nucleotide from the 3' end as "1".

각 영역의 정렬의 분석 과정에서, 각각의 서열을 각각의 기준 서열(앞에서 확인됨)과 비교하였으며, 모든 단리물에 대한 동일 영역을 결정하였다. 모든 잠재적인 리보자임 부위를 기준 서열에서 확인하였다. 리보자임 부위를 선택하는데 있어서 가장 우선시되는 것은 부위가 분할 부위와 결합 아암 모두에의 모든 위치에서 정렬된 모든 단리물에 대해 100% 동일성을 가져야 하는 것이다. 이러한 기준을 충족시키는 리보자임 부위를 선택하였다. 또한, 다음과 같은 2가지 특이적인 참작이 이루어졌다: 1) 잠재적인 리보자임 부위가 하나 또는 2개의 누클레오티드 위치를 제외하고 100% 서열 동일성을 갖는 경우에, 그 위치에서의 실제 누클레오티드를 구별된 단리물(들)중에서 조사하였다. "G:U 위블(wobble)" 염기쌍을 허용하도록 디자인된 리보자임이 모든 단리물상에서 작용할 수 있도록 상기 누클레오티드가 존재하는 경우에, 상기 부위를 선택하였다. 2) 잠재적인 리보자임 부위가 하나 또는 두개의 누클레오티드 위치를 제외하고 100% 서열 동일성을 갖는 경우에, 구별되는 누클레오티드(들)을 함유하는 단리물의 유전자형을 조사하였다. 구별되는 단리물의 유전자형이 극히 드물게 보급되는 경우에, 그 부위를 또한 선택하였다.In the course of analyzing the alignment of each region, each sequence was compared with each reference sequence (identified above) and the same region for all isolates was determined. All potential ribozyme sites were identified in the reference sequence. The first priority in selecting a ribozyme site is that the site should have 100% identity to all isolates aligned at all locations on both the split site and the binding arm. Ribozyme sites were selected that meet these criteria. In addition, two specific considerations have been made: 1) if the potential ribozyme site has 100% sequence identity except for one or two nucleotide positions, the isolation of the actual nucleotide at that position Irradiated in water (s). The site was chosen if the nucleotides were present such that ribozymes designed to allow "G: U wobble" base pairs could function on all isolates. 2) When potential ribozyme sites have 100% sequence identity except for one or two nucleotide positions, genotypes of isolates containing distinct nucleotide (s) were examined. If the genotype of the distinguishing isolates was extremely rarely spread, the site was also selected.

하기에서 확인되고 참조된 리보자임 부위는 다음과 같이 명명된다: "부위가 존재하는 게놈 영역" 이어서 "절단 부위에 대한 누클레오티드 영역 5'"(앞서 언급된 기준 서열 및 번호에 따름)를 명명하였다. 예를 들어, 5' NCR에서 누클레오티드 위치 67에서의 리보자임 절단 부위를 "5-67"로 지정하였고, 코어 코딩 영역에서 위치 48에서의 리보자임 절단 부위는 "c48"로 지정하였다.The ribozyme sites identified and referenced below are named as follows: "genomic region in which the site exists" followed by "nucleotide region 5 'to the cleavage site" (according to the aforementioned reference sequence and number). For example, the ribozyme cleavage site at nucleotide position 67 in the 5 'NCR was designated "5-67" and the ribozyme cleavage site at position 48 in the core coding region was designated "c48".

다수의 이러한 리보자임을 세포 배양 실험을 위한 적합한 리보자임 후보물질을 선택하기 위해 시험관내 HCV 절단 검정에서 스크리닝하였다. 스크리닝을 위해 선택된 리보자임은 HCV 번역에 필요한 5' UTR 영역을 표적화하였다. 이들 부위는 8개의 주요 HCV 유전자형 및 18개 서브타입 중에서 모두 보존되며, 상기 기술된 검정에 사용되었던 모든 HCV 단리물에서 고도의 상동성을 갖는다. 4개의 상이한 유전자형(1b, 2a, 4 및 5)의 HCV RNA를 사람 환자로부터 단리시키고, 5' HCV UTR 및 5' 코어 영역을 RT-PCR을 사용하여 증폭시켰다. 5' HCV UTR 영역의 런-오프(run-off) 전사체(750개 이하의 nt 전사체)를 T7 메가스크립트(Magascript) 전사 키트 및 제조업자 프로토콜(Ambion, Inc.)을 사용하여 T7 프로모터가 함유된 RT-PCR 생성물로부터 제조하였다. 혼입되지 않은 누클레오티드를 Bio-Gel P-60 수지(Bio-Rad)상에서 스핀 컬럼 여과에 의해 제거시켰다. 여과된 전사체를 폴리누클레오티드 키나아제(Boehringer/Mannheim)을 사용하여32P로, 효소 제조업자의 프로토콜을 이용하여 150μCi/㎕ 감마-32P-ATP(NEN)로, 5' 말단 표지화시켰다. 키나아제 처리된 전사체를 다시 스핀 정제시켜서, 혼입되지 않은 감마-32P-ATP를 제거하고, 5% 폴리아크릴아미드 겔상에서 정제시켰다.Many of these ribozymes were screened in an in vitro HCV cleavage assay to select suitable ribozyme candidates for cell culture experiments. The ribozyme selected for screening targeted the 5 'UTR region required for HCV translation. These sites are conserved among all eight major HCV genotypes and 18 subtypes and have a high degree of homology in all HCV isolates that were used in the assays described above. HCV RNAs of four different genotypes (1b, 2a, 4 and 5) were isolated from human patients and 5 'HCV UTR and 5' core regions were amplified using RT-PCR. Run-off transcripts (up to 750 nt transcripts) of the 5 'HCV UTR region were purified using the T7 Megascript transcription kit and manufacturer protocol (Ambion, Inc.). Prepared from the contained RT-PCR product. Unincorporated nucleotides were removed by spin column filtration on Bio-Gel P-60 resin (Bio-Rad). The filtered transcript was 5 'end labeled with 32 P using polynucleotide kinase (Boehringer / Mannheim) and 150 μCi / μL gamma-32P-ATP (NEN) using the protocol of the enzyme manufacturer. Kinase treated transcripts were again spin purified to remove unincorporated gamma-32P-ATP and purified on 5% polyacrylamide gels.

표 IV로부터의 다양한 부위를 표적화하는 리보자임을 선택하고, RNA 분해의 효율을 시험하기 위해 5' HCV UTR 전사체 서열에 대해 시험하였다. 15개 리보자임을 공지된 바와 같이 합성하였다 (Wincott et al., supra).Ribozymes that target various sites from Table IV were selected and tested for 5 ′ HCV UTR transcript sequence to test the efficiency of RNA degradation. Fifteen ribozymes were synthesized as known (Wincott et al., Supra).

검정을 리보자임 분해 완충액(50mM TRIS pH 7.5, 10mM MgCl2, 10 유닛 RNase 억제제(Boehringer/Mannheim), 10mM DTT, 0.5㎍ tRNA)에서 정제된 리보자임의 2X (2μM) 농도를 예비가온시킴으로써 수행하고, 절단 반응을 절단 완충액에서 또한 예비가온시킨 동 부피의 기질 RNA(17.46 pmole 최종 농도)에 2X 리보자임 혼합물을 첨가시킴으로써 개시시켰다. 검정을 1μM 리보자임의 최종 농도, 즉, 과량의 리보자임을 사용하여 37℃에서 24시간 동안 수행하였다. 반응을 동 부피의 95% 포름아미드, 20mM EDTA, 0.05% 브로모페놀 블루 및 0.05% 크실렌 시아놀을 첨가시킴으로써 켄칭(quenching)시킨 후, 샘플을 2분간 95℃로 가열하고, 급랭시키고, 변성 폴리아크릴아미드 겔상으로 로딩시켰다. 리보자임 절단에 의해 생성된 기질 RNA 및 특이적 RNA 분해 생성물을 겔의 자동방사선사진상에서 가시화시켰다. 분해의 퍼센트를 온전한 기질 및 절단 생성물을 나타내는 밴드의 포스포르 이미저(등록상표: Phosphor Imager) 정량에 의해 측정하였다.The assay was performed by prewarming 2 × (2 μM) concentrations of ribozyme purified in ribozyme digestion buffer (50 mM TRIS pH 7.5, 10 mM MgCl 2 , 10 unit RNase inhibitor (Boehringer / Mannheim), 10 mM DTT, 0.5 μg tRNA) The cleavage reaction was initiated by adding 2 × ribozyme mixture to the same volume of substrate RNA (17.46 pmole final concentration) which was also pre-warmed in cleavage buffer. The assay was performed at 37 ° C. for 24 hours using a final concentration of 1 μM ribozyme, ie excess ribozyme. The reaction is quenched by the addition of an equal volume of 95% formamide, 20 mM EDTA, 0.05% bromophenol blue and 0.05% xylene cyanol, and then the sample is heated to 95 ° C. for 2 minutes, quenched and modified poly Loading onto acrylamide gels. Substrate RNA and specific RNA degradation products generated by ribozyme cleavage were visualized on autoradiography of the gel. Percentage of degradation was determined by quantification of Phosphor Imager® of bands representing intact substrates and cleavage products.

겔로부터의 관찰된 절단 단편 크기를 RNA 마커와 비교하여 추정된 단편 크기와 상호관련시켰다. 예측된 절단 단편의 광학 밀도를 포스포르이미지 플레이트로부터 측정하고, 대부분의 절단 생성물을 나타내는 최고 밀도로부터 시험된 HCV 전사체의 각각의 유전자형의 최저치로 순위를 매겼다. 최고 3개의 절단 생성물(시험된 15개 리보자임 중에서)이 5의 순위 값으로 주어지고, 다음 3개의 최고 밀도가 4의 순위 값으로 주어지는 등, 시험된 모든 유전자형에 대해 등급이 주어진다. 각각의 리보자임에 대한 순위 값은 시험된 유전자형 사이에서 평균내어 진다. 개개의 리보자임 순위 값 및 평균값이 도시되고, 비교된다. 결과(도 2)는 다수의 이러한 시험된 리보자임이 유전자형에 관계없이 높은 수준의 절단을 제공할 수 있음을 나타낸다. 특히, 리보자임 표적화 부위 HCV.5-258, HCV.5-294, HCV.5-313(Sakamoto et al., J Clinical Investigation 1996 98(12):2720-2728), 및 HCV.5-318(표 IV)는 RNA 분해의 일관된 패턴을 나타내는 것으로 여겨진다.The observed cleavage fragment size from the gel was correlated with the estimated fragment size compared to the RNA marker. The optical density of the predicted cleavage fragments was measured from phosphorimage plates and ranked from the highest density representing the most cleavage products to the lowest of each genotype of the tested HCV transcript. Up to three cleavage products (of 15 ribozymes tested) are given a rank value of 5, and the next three highest densities are given a rank value of 4, which gives a rating for all genotypes tested. Rank values for each ribozyme are averaged among the genotypes tested. Individual ribozyme rank values and mean values are shown and compared. The results (FIG. 2) show that many of these tested ribozymes can provide high levels of cleavage regardless of genotype. In particular, ribozyme targeting sites HCV.5-258, HCV.5-294, HCV.5-313 (Sakamoto et al., J Clinical Investigation 1996 98 (12): 2720-2728), and HCV.5-318 ( Table IV) is believed to represent a consistent pattern of RNA degradation.

실시예 7: OST7 세포내에서 HCV 표적화 리보자임을 사용하는 루시페라제 효소활성의 저해Example 7: Inhibition of Luciferase Enzyme Activity Using HCV Targeting Ribozyme in OST7 Cells

리보자임이 HCV RNA을 내세포성으로 저해하는 능력을 반딧불 및 레닐라 루시페라제(도 3)을 사용하는 이중 수용기 시스템을 이용하여 시험했다. 5' HCV UTR 영역에 표적화된 리보자임은 절단된 경우에, 전사체가 루시페라제로 번역되지 못하게 하였다. OST-7 세포를 소 태아 혈청 10%, 펜/스트렙 1%, 및 L-글루타민을 함유하는 DMEM 배지내에서 암벽(blacked walled)의 96개의 웰 플레이트 (Packerd)중에 각 웰당 12,5000 세포로 플레이팅시키고, 37℃에서 하룻밤 배양시켰다. 5' HCV UTR을 발현하는 T7 프로모터 및 반딧불 루시페라제(T7C1-341(Wang et al., 1993, J. of Virol. 67, 3338-3344))를 함유하는 플라스미드를 pRLSV40 레닐라 조절 플라스미드(Promega Corporation)과 함께 혼합시킨 후, 리보자임, 및 양이온성 지방을 혼합시켜, 5X 농도의 시약(T7C1-341(4㎍/ml), pRLSV40 레닐라 루시페라제 조절제(6㎍/ml), 리보자임(250nM), 트랜스팩션 시약(28.5㎍/ml)를 제조했다.The ability of ribozymes to inhibit HCV RNA endogenously was tested using a dual receptor system using fireflies and Renilla luciferase (FIG. 3). Ribozymes targeted to the 5 'HCV UTR region prevented transcripts from being translated into luciferase when cleaved. OST-7 cells were played at 12,5000 cells per well in 96 well plated 96 well plates in DMEM medium containing 10% fetal bovine serum, 1% pen / strep, and L-glutamine And incubated overnight at 37 ° C. Plasmids containing the T7 promoter and firefly luciferase (T7C1-341 (Wang et al., 1993, J. of Virol. 67, 3338-3344)) expressing the 5 'HCV UTR were transferred to the pRLSV40 Renilla regulatory plasmid (Promega). After mixing with Ribozyme, and cationic fats, the reagent was mixed at 5X concentration (T7C1-341 (4 μg / ml), pRLSV40 Renilla Luciferase Modulator (6 μg / ml), ribozyme). (250 nM) and a transfection reagent (28.5 μg / ml) were prepared.

상기 복합체 혼합물을 37℃에서 20분동안 배양시켰다. 세포로부터 배지를 제거하고, 옵티-멤(Opti-mem) 배지 120㎕를 웰에 가한 후, 상기 5배 복합체 혼합물 30㎕를 가했다. 상기 옵티-멤 150㎕를 미처리 세포를 지닌 웰에 가했다. 상기 복합체 혼합물을 허성(passive) 용해 완충액 (Promega Corporation)으로 용해시킨 OST-7 세포상에서 4시간 동안 배양시키고, 제조자의 지침(Promega Corporation)에 따라 Dual Luciferase Assay Kit를 사용하여 발광성 신호를 정량했다. 사용된 리보자임 서열을 표 Ⅳ에 나타냈다. 상기 사용된 리보자임은 해머헤드 (hammerhead) 모티프였다. 상기해머헤드 리보자임을 화학적으로 변형시켜 상기 리보자임을 5개의 부위에서 리보스 잔기로 구성되도록 하였다(예를 들어, 도 7 참조); 제 4 위치는 2'-C-알릴 또는 2'-아미노 변형을 가졌으며; 제 7 위치는 2'-아미노 변형 또는 2'-O-메틸 변형을 가졌고; 나머지 누클레오티드 위치는 2'-O--메틸 치환기를 함유하며; 5'-말단의 4개의 누클레오티드는 포스포로티오에이트 치환기를 함유했다. 또한, 리보자임의 3'-말단은 3'-3' 결합된 역위 비염기성 성분(비염기성 데옥시리보스; iH)을 포함한다. 상기 데이터(도 4)는 반딧불 및 레닐라 루시페라제 형광성 사이의 비율을 나타낸다. 5' HCV UTR을 표적화하는 모든 리보자임이 레닐라 루시페라제에 대한 반딧불 루시페라제 시그널을 감소시켰다.The complex mixture was incubated at 37 ° C. for 20 minutes. The medium was removed from the cells, 120 μl of Opti-mem medium was added to the wells, and then 30 μl of the 5-fold complex mixture was added. 150 μl of the Opti-Mem was added to the wells with untreated cells. The complex mixture was incubated for 4 hours on OST-7 cells dissolved in passive lysis buffer (Promega Corporation) and luminescent signals were quantified using the Dual Luciferase Assay Kit according to the manufacturer's instructions (Promega Corporation). The ribozyme sequences used are shown in Table IV. The ribozyme used was a hammerhead motif. The hammerhead ribozyme was chemically modified such that the ribozyme was composed of ribose residues at five sites (see, eg, FIG. 7); The fourth position had a 2'-C-allyl or 2'-amino modification; The seventh position had a 2'-amino modification or a 2'-0-methyl modification; The remaining nucleotide position contains a 2'-0-methyl substituent; Four nucleotides of the 5'-end contained phosphorothioate substituents. In addition, the 3'-terminus of the ribozyme comprises a 3'-3 'bound inverted nonbasic component (nonbasic deoxyribose; iH). The data (FIG. 4) show the ratio between firefly and Renilla luciferase fluorescence. All ribozymes targeting the 5 'HCV UTR reduced the firefly luciferase signal for Renilla luciferase.

실시예 9: OST-7 세포내에서 불활성 대조와 비교한 루시페라제 활성의 리보자임 매개 저해Example 9: Ribozyme-mediated Inhibition of Luciferase Activity in Comparison with Inactive Controls in OST-7 Cells

상기 이중 수용기 시스템을 사용하여 불활성 대조와 비교한 리보자임에 의해 매개된 루시페라제 활성의 감소 수준을 측정했다. 상기 실시예에 기술한 화학적 조성물을 갖는, HCV 313 및 318(표 Ⅳ) 부위에 대한 리보자임 및 이들의 불활성 대조를 상기와 같이 합성했다. 상기 불활성 대조는 활성 리보자임과 동일한 누클레오티드 염기 조성을 가지나, 상기 누클레오티드 서열은 스크램블링되어 있었다. 조직 배양 및 루시페라제 검정을 위해 사용한 상기 규정을 실시예 8에 제시했으며, 실시예 8은 5배 복합체 혼합물중의 리보자임 농도가 1mM(세포상 최종 농도는 200nM)인 것을 제외하고는 상기 규정과 동일하였다.The dual receptor system was used to measure the level of decrease in luciferase activity mediated by ribozyme compared to the inactive control. Ribozymes and their inert controls for the HCV 313 and 318 (Table IV) sites, with the chemical composition described in the above examples, were synthesized as above. The inactive control had the same nucleotide base composition as the active ribozyme, but the nucleotide sequence was scrambled. The above definitions used for tissue culture and luciferase assays are presented in Example 8, except that Example 8 has the above rule except that the ribozyme concentration in the 5-fold complex mixture is 1 mM (cell final concentration is 200 nM). Was the same as

그 결과를 도 5에 나타냈다. HCV.5-318을 표적화하는 리보자임은 미처리된 불활성의 대조와 비교하여 반딧불 루시페라제 활성을 현저하게 감소시켰다. 상기 HCV.5-313을 표적화하는 리보자임은 반딧불 루시페라제 활성을 불활성 대조와 비교해 다소 감소시킬 수 있었다.The result is shown in FIG. Ribozymes targeting HCV.5-318 markedly reduced firefly luciferase activity compared to untreated inactive controls. Ribozymes targeting the HCV.5-313 could slightly reduce firefly luciferase activity compared to inactive controls.

실시예 10: 리보자임의 바이러스 복제 저해Example 10 Inhibition of Viral Replication by Ribozyme

HCV 감염중에, 바이러스성 RNA는 수개의 과정에서 리보자임 절단에 대한 잠재적 표적으로서 존재한다: 언코팅(uncoating), 번역, RNA 복제 및 패키징. 표적 RNA는 상기 단계들 중 어느 하나의 단계중에서 리보자임 절단에 대해 어느정도 접근할 수 있다. 비록, HCV 5'UTR/루시페라제 수용기 시스템(실시예 9)내에서 HCV 개시 라이보좀 유입 부위(IRES)와 번역 기관과의 결합이 흉내내어지나, 이들 다른 바이러스성 과정은 OST7 시스템에서 나타나지 았았다. 그 결과인 표적 바이러스성 RNA와 결합된 RNA/단백질 복합체는 또한 없었다. 또한, 이들 과정은 추가로 표적 RNA 접근성에 충격을 가할 수 있는 HCV-감염된 세포중에 결합될 수 있었다. 따라서, 본 발명자들은 HCV 5'UTR을 절단시키기 위해 설계한 리보자임이 복제 바이러스 시스템에 영향을 줄 수 있는지 여부를 시험했다.During HCV infection, viral RNA exists as a potential target for ribozyme cleavage in several processes: uncoating, translation, RNA replication and packaging. The target RNA may have some access to ribozyme cleavage during any of the above steps. Although the association of HCV initiating ribosomal inlet site (IRES) with translational organs in the HCV 5'UTR / luciferase receptor system (Example 9) is mimicked, these other viral processes have not been shown in the OST7 system. It was. There was also no RNA / protein complex associated with the resulting target viral RNA. In addition, these procedures could be further coupled to HCV-infected cells that could impact target RNA accessibility. Therefore, we tested whether ribozymes designed to cleave HCV 5'UTR can affect the replication virus system.

최근에, 루(Lu)와 위머(Wimmer)가 HCV-폴리오바이러스 키메라를 특성화시켰으며, 여기서 폴리오바이러스 IRES가 HCV로부터의 IRES에 의해 치환되었다(Lu ＆ Wimmer, 1996, Proc. Natl. Acad. Sci. USA. 93, 1412-1417). 폴리오바이러스(PV)는 HCV와 같은 양성 외가닥 RNA 바이러스이나, HCV와는 달리 엔벨로핑되지 않았으며, 세포 배양액 중에서 효과적으로 복제한다. 상기 HCV-PV 키메라는 야생형 PV와 비교하여 안정적이고, 작은 플라크 표현형을 발현한다.Recently, Lu and Wimmer have characterized the HCV-Poliovirus chimera, where the poliovirus IRES has been replaced by IRES from HCV (Lu & Wimmer, 1996, Proc. Natl. Acad. Sci). USA, 93, 1412-1417). Poliovirus (PV) is a positive single stranded RNA virus such as HCV, but unlike HCV, it is not enveloped and effectively replicates in cell culture. The HCV-PV chimera is stable compared to wild type PV and expresses a small plaque phenotype.

실험을 위해 하기 리보자임을 합성했다(표 Ⅷ): 리보자임 표적화 부위 183(3 5'-말단 포스포로티오에이트 결합), 183 부위에서 스크램블링된 대조, 318 부위(3 5'-말단 포스포로티오에이트 결합)에 대한 리보자임, 리보자임 표적화 부위 183(4 5'-말단 포스포로티오에이트 결합), 불활성 리보자임 부위 183(4 5'-말단 포스포로티오에이트). 헬라 세포를 HCV-PV 키메라를 사용하여 30분동안 감염시킨 직후에 리보자임으로 처리했다. 헬라세포를 U-바닥 96개의 웰 플레이트에 9000-10000 세포/웰의 밀도로 시딩하고, CO25%하에서 24시간 동안 37℃에서 배양시켰다. 리보자임(200nM)의 트랜스팩션을 10X 리보자임(2000nM)과 양이온성 지방(80㎍/㎖)을 DMEM(Gibco BRL)중에서 소 태아 혈청(FBS) 5%와 혼합시킴에 의해 수행했다. 리보자임/지방 복합체를 CO25%하에서 37℃에서 15분동안 배양시켰다. 세포로부터 배지를 제거하고, FBS 혈청 5%와 함께 DMEM(Gibco BRL) 80㎕로 치환시킨 다음, 10X 복합체 20㎕를 가했다.The following ribozymes were synthesized for the experiment (Table VII): ribozyme targeting site 183 (3 5'-terminal phosphorothioate linkage), control scrambled at 183 site, 318 site (3 5'-terminal phosphorothio) Ribozyme targeting ribozyme targeting site 183 (4 5'-terminal phosphorothioate linkage), inactive ribozyme site 183 (4 5'-terminal phosphorothioate). HeLa cells were treated with ribozyme immediately after infection for 30 minutes with HCV-PV chimeras. HeLa cells were seeded in a U-bottom 96 well plate at a density of 9000-10000 cells / well and incubated at 37 ° C. for 24 hours under 5% CO 2 . Transfection of ribozyme (200 nM) was performed by mixing 10 × ribozyme (2000 nM) and cationic fat (80 μg / ml) with 5% fetal bovine serum (FBS) in DMEM (Gibco BRL). Ribozyme / fat complexes were incubated for 15 minutes at 37 ° C. under 5% CO 2 . The medium was removed from the cells, replaced with 80 μl of DMEM (Gibco BRL) with 5% FBS serum, and 20 μl of 10 × complex added.

처리한 세포로부터 HCV-PV의 수율(도 6a)을 플라크 분석으로 정량했다. 상기 플라크 분석은 바이러스 샘플을 혈청 부재의 DMEM(Gibco BRL)중에 희석시키고 100㎕를 6-웰 플레이트내의 헬라 세포 단층(~80% 융합체)에 30분동안 적용시켜 수행했다. 감염시킨 단층을 1.2% 한천(시그마) 3ml와 포개고, CO25%하 37℃에서 배양시켰다. 2-3일 후에, 상기 겹친층을 제거하고, 단층을 크리스탈 바이올렛트 1.2%로 염색시키고, 플라크 형성 단위를 계수했다. 상기 데이터를 도 6a네 나타냈다. 스크램블링된 대조와 비교하여, 부위 183에 대한 리보자임은 80% 초과(P ＜ 0.05)하여 HCV-PV 복제를 저해했다(도 6a의 최초 2개의 막대). 또한, 3 또는 4 포스포로티오에이트 안정화는 바이러스 복제의 저해중에 동등하게 효과적이었다 (P＜0.05 대 대조 각각)(도 6a에서 첫번째와 네번째 막대의 비교). 318 부위에 대한 리보자임은 바이러스 복제에 대해 통계적으로 상당한(P ＜ 0.05) 영향을 가졌다(도 6a에서 제 2와 제 3 막대의 비교).The yield of HCV-PV (FIG. 6A) from the treated cells was quantified by plaque analysis. The plaque assay was performed by diluting virus samples in serum-free DMEM (Gibco BRL) and applying 100 μl to HeLa cell monolayers (˜80% fusion) in 6-well plates for 30 minutes. Infected monolayers were superimposed with 3 ml of 1.2% agar (Sigma) and incubated at 37 ° C. under 5% CO 2 . After 2-3 days, the layer was removed, the monolayer was dyed with 1.2% of crystal violet, and plaque forming units were counted. The data is shown in FIG. 6A. Compared with the scrambled control, the ribozyme for site 183 inhibited HCV-PV replication by more than 80% (P <0.05) (first two bars in FIG. 6A). In addition, 3 or 4 phosphorothioate stabilization was equally effective during inhibition of viral replication (P <0.05 vs. control, respectively) (comparison of the first and fourth bars in FIG. 6A). Ribozymes for the 318 site had a statistically significant (P <0.05) effect on virus replication (comparison of the second and third bars in FIG. 6A).

리보자임 절단 메카니즘이 관찰된 HCV-PV 복제의 저해에 책임이 있음을 확인하기 위해, 결합 아암(arm) 서열을 유지하지만 촉매 코어에 돌연변이를 함유하여 절단 활성을 저하시킨 HCV-PV 감염된 세포를 부위 183에 대한 리보자임으로 처리했다. 이들 세포에서의 바이러스 복제는 스크램블링된 대조 라이보좀으로 처리한 세포와 비교할 경우에, 저해되지 않았으며(도 6a, 제4 및 제 5 막대), 이는 리보자임 절단 활성이 관찰된 HCV-PV 복제의 저해에 필요함을 지시한다. 또한, 리보자임 표적화 부위 183인 HCV 5' UTR은 야생형 PV 복제에 대해서는 아무런 영향이 없었다(도 6b). 이들 데이터는 HCV-PV 복제의 리보자임 매개 저해가 HCV 5' UTR 의존성이며, PV 복제의 일반적인 저해가 아니라는 데 대한 증거를 제공했다.To confirm that the ribozyme cleavage mechanism is responsible for the observed inhibition of HCV-PV replication, sites of HCV-PV infected cells that retain binding arm sequences but contain mutations in the catalyst core that degrade cleavage activity Treated as a ribozyme for 183. Viral replication in these cells was not inhibited when compared to cells treated with scrambled control ribosome (FIGS. 6A, 4 and 5 bars), indicating that ribozyme cleavage activity was observed for HCV-PV replication. Indicates necessary for inhibition. In addition, HCV 5 ′ UTR, ribozyme targeting site 183, had no effect on wild-type PV replication (FIG. 6B). These data provided evidence that ribozyme mediated inhibition of HCV-PV replication is HCV 5 ′ UTR dependent and not a general inhibition of PV replication.

또한, 부위 183에 대한 리보자임을 헬라 세포에서 단일 감염 사이클중 HCV-PV 복제에 대한 저해력을 시험하기 위해 시험했다(도 8). 부위 183에 대한 리보자임으로 처리한 세포(7/4 포멧)는 스크램블링된 대조(감염 후 8시간째에 80% 초과의 저해, P ＜ 0.001)를 사용하여 처리한 세포보다 현저히 적은 양의 바이러스를 생성시켰다.In addition, ribozyme for site 183 was tested to test the inhibition of HCV-PV replication in a single infection cycle in HeLa cells (FIG. 8). Cells treated with ribozyme for site 183 (7/4 format) contained significantly less virus than cells treated with the scrambled control (> 80% inhibition at 8 hours post infection, P <0.001). Generated.

실시예 11: 리보자임 길이의 단축Example 11: Reduction of Ribozyme Length

상기 실시예 10에 기술한 모든 리보자임은 각각의 결합 아암에 7개 누클레오티드를 함유하였고, 4개의 염기쌍 스템 Ⅱ 성분(7/4 포멧)을 함유했다. 치료적 리보자임의 약제학적 제조를 위해, 가능하다면 서열의 길이를 최소화시키는 것이 유리하다. 이와 같이, 부위 183에 대한 리보자임을, 리보자임이 각각의 결합 아암에 6개의 누클레오티드를 가지며 스템 Ⅱ 영역이 4개의 염기쌍 길이(6/4 포멧)를 갖도록 외부의 대부분의 누클레오티드를 각각의 결합 아암으로부터 제거하고; 스템 Ⅱ 내의 하나의 염기쌍(2 누클레오티드)을 제거하여 3 염기쌍 스템 Ⅱ(7/3 포멧)를 만들거나; 또는 각각의 결합 아암으로부터 하나의 염기쌍을 제거하여 하나의 염기쌍만큼 스템 Ⅱ를 단축시킴으로써 단축시켰다. (각각의 이들 리보자임을 개략적으로 나타낸 도 7 참조). 7/4, 7/3, 및 6/3 포멧을 사용하여 시험한 모든 포멧에서의 리보자임이 8시간째에 거의 동일한 바이러스 복제의 저해를 가져왔다(모든 포멧에 대한 시간 경로를 거쳐 P ＜ 0.001). 시험한 것 중 가장 짧은 리보자임(6/3 포멧)이 7/4 리보자임(~80% 저해, P ＜ 0.001) 보다 약간 더 효과적이었다(＞ 90% 저해, P ＜ 0.001). 상기 6/3 리보자임은 HCV-PV 키메라중 부위 183에 대한 보다 더 큰 접근 가능성을 가질 수 있다.All ribozymes described in Example 10 above contained 7 nucleotides in each binding arm and 4 base pair stem II components (7/4 format). For pharmaceutical preparation of therapeutic ribozymes, it is advantageous to minimize the length of the sequence if possible. As such, ribozyme for site 183, the outer most of the nucleotides in each binding arm such that the ribozyme has 6 nucleotides in each binding arm and the stem II region is 4 base pairs long (6/4 format) Remove from; Removing one base pair (2 nucleotides) in stem II to form a three base pair stem II (7/3 format); Or by shortening Stem II by one base pair by removing one base pair from each binding arm. (See FIG. 7 schematically showing each of these ribozymes). Ribozymes in all formats tested using the 7/4, 7/3, and 6/3 formats resulted in nearly identical inhibition of viral replication at 8 hours (via P <0.001 over the time path for all formats). ). The shortest ribozyme (6/3 format) tested was slightly more effective than 7/4 ribozyme (˜80% inhibition, P <0.001) (> 90% inhibition, P <0.001). The 6/3 ribozyme may have greater accessibility to site 183 in HCV-PV chimeras.

실시예 12: HCV 리보자임과 인터페론의 조합 치료Example 12 Combination Treatment of HCV Ribozyme and Interferon

헬라 세포(웰당 10,000 세포수)를 완전 배지(DMEM + 5% FBS)중의 인터페론 알파 12.5 Units/ml를 사용하거나, 완전 배지 단독으로 4시간 동안 예비 처리시킨 후, MOI=0.1 에서 30분동안 감염시켰다. 다음, 상기 바이러스 접종을 제거하고, 리보자임의 결합력을 극심하게 감소시키는 리보자임의 촉매 코어중의 돌연변이를 가지는, HCV 부위 183(Rz)에 대해 표적화시킨 리보자임 또는 결합력 감소된 대조 (BAC) 200nM를 완전배지에서 24시간 동안 양이온성 지방을 사용하여 전달했다. 바이러스 수율을 ml당 평균 플라크 형성 유니트로 (pfu/ml) + SEM으로 나타냈다. 상기 데이터를 도 10에 제시했다.HeLa cells (10,000 cells per well) were infected with interferon alpha 12.5 Units / ml in complete medium (DMEM + 5% FBS) or pretreated for 4 hours with complete medium alone and then infected for 30 minutes at MOI = 0.1. . Next, ribozyme or avidity reduced control (BAC) 200 nM targeted against HCV site 183 (Rz), which eliminates the virus inoculation and has a mutation in the ribozyme catalytic core that severely reduces the binding capacity of ribozyme. Was delivered using cationic fat for 24 hours in complete medium. Virus yields are expressed as average plaque forming units per ml (pfu / ml) + SEM. The data is presented in FIG. 10.

인터페론(IFN)을 사용한 예비처리가 대조 세포에서 바이러스 수율을 ~10-1가지 감소시켰다(BAC+IFN 대 BAC). 리보자임 처리한 세포는 대조 처리한 세포보다 2x10-1적게 생산하였다(Rz 대 BAc). Rz와 IFN 처리의 조합은 바이러스 수율에서 4x10-2의 상승적 감속를 가져왔다(Rz+IFN 대 BAC). 다른 부가의 효과는 단지 3x10-1감소만을 가져왔다(1x10-1+ 2x10-1).Pretreatment with interferon (IFN) reduced ˜10-1 virus yield in control cells (BAC + IFN vs BAC). Ribozyme treated cells produced 2 × 10 −1 less than control treated cells (Rz vs. BAc). The combination of Rz and IFN treatment resulted in a synergistic slowdown of virus yield of 4 × 10 −2 (Rz + IFN vs BAC). Effect of different addition is only brought only 3x10 -1 reduction (1x10 -1 + 2x10 -1).

실시예 13: 다른 리보자임 모티프를 사용한 간염 C 바이러스의 저해Example 13: Inhibition of Hepatitis C Virus with Different Ribozyme Motifs

많은 다양한 종류의 리보자임 모티프(RPI 모티프 1-3; 도 9)를 조직배양중 HCV 증식에 대한 저해력에 대해 시험했다. RPI 모티프 Ⅰ의 한 예는 문헌(Kore et al., 1998, Nucleic Acid Research 26, 4116-4120)에 기술되었으며, RPI 모티프 Ⅱ의 일예는 루드빅 및 스프로앳트(Ludwig ＆ Sproat)의 국제 특허출원 PCT 공개공보 WO 98/58058에 기술되었다. RPI 모티프 Ⅲ은 출원인이 최근에 개발한 신규한 리보자임 모티프이며, 상기 모티프의 한 예를 본원에서 시험했다.Many different types of ribozyme motifs (RPI motifs 1-3; FIG. 9) were tested for inhibition of HCV proliferation during tissue culture. An example of RPI motif I is described in Kore et al., 1998, Nucleic Acid Research 26, 4116-4120, and one example of RPI motif II is the international patent application PCT of Ludwig & Sproat. It is described in publication WO 98/58058. RPI Motif III is a novel ribozyme motif recently developed by Applicants, an example of which was tested herein.

OST7 세포를 10% 소 태아 혈청, L-글루타민(2mM), 및 페니실린/스트렙토마이신을 부가시킨 Dulbecco의 변형된 Eagle 배지중에 보유시켰다. 트랜스펙션을 위해, OST 세포를 암벽 96-웰 플레이트(Parkard Instrument)내에 12,500 세포/웰의 밀도로 시딩하고 5% CO2하 37℃에서 24시간 동안 배양시켰다. 표적 수용기 HCVT7C (0.8㎍/ml), 대조 수용기 pRLSV40(1.2㎍/ml), 및 리보자임(50-200nM)의 코트랜스펙션을 하기 방법에 따라 수행했다: HCVT7C(4㎍/ml) 5X 혼합물, pRLSV40(6㎍/ml), 리보자임(250-1000nM), 및 양이온성 지방(28.5㎍/ml)를 OPTI-MEM(GIBCO BRL) 마이너스 혈청 150㎕중에 제조했다. 수용기/리보자임/지방 복합체가 5% CO2하 37℃에서 20분동안 형성되도록 했다. OST7 세포로부터 배지를 제거하고 OPTI-MEM (GIBCO BRL) 마이너스 혈청 120㎕로 치환시킨 후, 즉시 5X 수용기/리보자임/ 지방 복합체 30㎕를 가했다. 세포를 5% CO2하 37℃에서 4시간 동안 배양했다. 실시예 7에따라 루시페라제를 분석했다. 데이터를 대조와 함께 각각의 모티프의 결과를 표 Ⅸ에 요약했다. 모든 리보자임 모티프는 어떠한 HCV에도 표적화시키지 않은 라이보좀(무관한 대조)과 비교하여, HCV 생성량을 감소시킬 수 있었다.OST7 cells were retained in Dulbecco's modified Eagle's medium with 10% fetal bovine serum, L-glutamine (2 mM), and penicillin / streptomycin. For transfection, OST cells were seeded at a density of 12,500 cells / well in a rock wall 96-well plate (Parkard Instrument) and incubated for 24 hours at 37 ° C. under 5% CO 2 . Coatfection of the target receptor HCVT7C (0.8 μg / ml), control receptor pRLSV40 (1.2 μg / ml), and ribozyme (50-200 nM) was performed according to the following method: HCVT7C (4 μg / ml) 5X mixture , pRLSV40 (6 μg / ml), ribozyme (250-1000 nM), and cationic fat (28.5 μg / ml) were prepared in 150 μl of OPTI-MEM (GIBCO BRL) minus serum. Receptor / ribozyme / fat complexes were allowed to form for 20 minutes at 37 ° C. under 5% CO 2 . Medium was removed from OST7 cells and replaced with 120 μl of OPTI-MEM (GIBCO BRL) minus serum, followed immediately by 30 μl of 5 × receptor / ribozyme / fat complexes. Cells were incubated for 4 hours at 37 ° C. under 5% CO 2 . Luciferase was analyzed according to Example 7. The results of each motif are summarized in Table VII along with the control. All ribozyme motifs were able to reduce HCV production compared to ribosomes that did not target any HCV (irrelevant controls).

세포 배양 분석Cell culture assay

세포 배양물중의 HCV 복제에 대한 보고서가 있으나(하기 참조), 이들 시스템은 복제하기 어렵고 신뢰성이 없는 것으로 밝혀졌다. 따라서, 다른 항-HCV 치료제예컨데, 인터페론 및 리바비린의 개발에서와 같이, 동물연구에서의 안정성을 입증한 후에 본 발명자들은 임상적 적용가능성에 대한 연구를 수행했다.There are reports of HCV replication in cell cultures (see below), but these systems have been found to be difficult and unreliable to replicate. Thus, after demonstrating stability in animal studies, as in the development of other anti-HCV therapies such as interferon and ribavirin, we conducted a study of clinical applicability.

최근 수개의 보고서는 인간 세포주에서의 HCV의 시험관내 증식을 기술했다. 참고문헌:Several recent reports have described in vitro proliferation of HCV in human cell lines. references:

HCV의 복제를 T 세포 및 B 세포, 및 인간 간세포로부터 유도한 세포주에서 입증했다. 복제의 입증을 RT-PCR 기초 검정 또는 b-DNA 검정을 사용하여 기록하였다. HCV 에 대한 대부분의 최근의 간행물이 6주이하 동안의 복제를 기록함은 주목할 만하다. HCV로 감염될 수 있는 세포주에 추가하여, 수개의 그룹이 전장 또는 부분적 HCV 게놈의 cDNA 클론을 사용한 세포주의 성공적인 형질전환을 보고했다. 참고문헌:Replication of HCV was demonstrated in T cells and B cells, and in cell lines derived from human hepatocytes. Proof of replication was recorded using RT-PCR based assay or b-DNA assay. It is noteworthy that most recent publications on HCV record replication for less than six weeks. In addition to cell lines that may be infected with HCV, several groups have reported successful transformation of cell lines using cDNA clones of full-length or partial HCV genomes. references:

동물 모델Animal model

HCV 시스템에 대해 가장 잘 특성화된 동물 시스템은 침팬치이다. 또한, 침팬치 및 인간에서의 HCV의 감염에 의한 결과인 만성 간염은 매우 유사하다. 비록 임상적으로 관련되지만, 침팬치 모델은 이들 모델의 사용을 어렵게하는 수개의 실제적인 장애를 겪고 있다. 이러한 장애는 하기를 포함한다: 고비용, 오랜 양육기간의 필요성, 및 충분한 양의 동물의 부족. 이러한 요인들 때문에 많은 그룹에서 만성 간염 C 감염의 설치류 모델을 개발하고자 시도하였다. 직접적인 감염이 불가능한 반면에, 수개의 그룹은 일부 또는 전부의 HCV 게놈의 설치류에 대한 안정적인 트랜스팩션 대해 보고했다. 참고문헌:The best characterized animal system for HCV systems is chimpanzees. In addition, chronic hepatitis resulting from infection of HCV in chimpanzees and humans is very similar. Although clinically relevant, chimpanzee models suffer from several practical obstacles that make their use difficult. Such disorders include: high cost, the need for long parenting periods, and a lack of sufficient amounts of animals. Because of these factors, many groups have attempted to develop rodent models of chronic hepatitis C infection. While direct infection is not possible, several groups reported stable transfection of rodents of some or all HCV genomes. references:

또한, HCV로 감염된 인간의 간을 면역보충된 마우스로 이식함은 마우스의 혈액에서 HCV RNA의 검출을 연장시키는 결과를 가져왔다.In addition, transplanting human livers infected with HCV into immunosupplemented mice resulted in prolonged detection of HCV RNA in the blood of mice.

진단 용도Diagnostic purpose

본 발명의 리보자임은 질환에 걸린 세포내에서 유전적 드리프트 및 돌연변이를 조사하기 위해 또는 세포내의 HCV의 존재를 검출하기 위한 도구로서 사용될 수 있다. 리보자임의 활성과 표적 RNA의 구조와의 밀접한 관련성은 분자내의 임의의 영역에서의 돌연변이를 검출하는 것이 가능하도록 하고, 이는 표적 RNA의 염기 쌍 및 3차원 구조를 변경시켰다. 본원에 기술된 다중 리보자임을 사용함에 의해, 시험관내, 세포 및 조직내에서 RNA의 구조 및 기능에 중요한 누클레오티드의 변화를 맵핑할 수 있다. 리보자임을 사용한 표적 RNAs의 절단은 유전자 발현을 저해하고 질환의 진행중 특정 유전자 생성물의 (주요) 역할을 규정하는데 사용될 수 있다. 이러한 방법으로, 다른 유전자 표적이 질환의 중요한 매개자로서 정의될 수 있다. 이들 실험은 조합 치료(예를 들어, 다른 유전자에 표적화된 다중 리보자임, 공지의 작은 분자 저해제와 결합된 리보자임, 또는 리보자임 및/또는 다른 화학적 또는 생물학적 분자의 조합을 이용한 단속적 치료)를 가능하게 함에 의해 질환의 경과의 보다 더 우수한 치료를 유도할 것이다. 본 발명의 리보자임의 다른 시험관내 용도가 당업계에 잘 알려졌으며, HCV 관련 조건과 연관된 mRNA의 존재의 검출을 포함한다. 이러한 RNA는, 표준 방법을 사용하여 리보자임으로 처리한 후의 절단 생성물의 존재를 결정함에 의해 측정될 수 있다.The ribozymes of the present invention can be used to investigate genetic drift and mutations in diseased cells or as a tool for detecting the presence of HCV in cells. The close relationship between the activity of the ribozyme and the structure of the target RNA made it possible to detect mutations in any region in the molecule, which altered the base pair and three-dimensional structure of the target RNA. By using the multiple ribozymes described herein, changes in nucleotides important to the structure and function of RNA in vitro, cells and tissues can be mapped. Cleavage of target RNAs using ribozymes can be used to inhibit gene expression and define the (major) role of certain gene products during the course of the disease. In this way, other genetic targets can be defined as important mediators of the disease. These experiments allow for combination therapy (e.g., multiple ribozymes targeted to different genes, ribozymes combined with known small molecule inhibitors, or intermittent treatment with a combination of ribozymes and / or other chemical or biological molecules). This will lead to better treatment of the course of the disease. Other in vitro uses of ribozymes of the invention are well known in the art and include the detection of the presence of mRNA associated with HCV related conditions. Such RNA can be measured by determining the presence of the cleavage product after treatment with ribozyme using standard methods.

특정 실시예에서, 표적 RNA의 단지 야생형 또는 돌연변이형만을 절단할 수 있는 리보자임을 분석에 사용했다. 제 1의 리보자임을 샘플내의 야생형 RNA의 존재를 동정하는데 사용하였고, 제 2의 리보자임을 샘플내의 돌연변이 RNA를 동정하는데 사용했다. 반응 대조로서, 야생형 및 돌연변이 RNA의 합성 기질을 리보자임 양자 모두를 사용하여 절단시킴에 의해 반응에서의 리보자임의 상대적 효율성 및 "비표적화"시킨 RNA 종의 절단의 부재를 입증했다. 합성 기질로부터의 상기 절단 생성물은 샘플에서의 야생형 및 돌연변이 RNAs의 분석을 위한 사이즈 마커를 생성시키는데 기여했다. 이와같이, 각각의 분석은 2개의 리보자임, 두개의 기질, 및 6개의 반응으로 결합되는 하나의 알려지지 않은 샘플을 필요로하였다. 상기 절단 생성물의 존재는 RNase 분석을 사용하여 측정할 수 있으며, 그 결과 각각의 RNA의 전장 및 절단 단편을 폴리아크릴아미드 겔의 하나의 레인중에 분석할 수 있었다. 돌연변이 RNAs의 발현 및 표적 세포내에서의 목적하는 표현형 변환의 잠재적 위험성에 대한 통찰을 얻기 위해 상기 결과를 정량화할 절대적 필요성이 있는 것은 아니다. 그의 단백질 생성물이 표현형(즉, HCV)의 개발중에 연관된 mRNA의 발현은 의험을 설정하는데 적절했다. 필적하는 특이적 활성의 프로우브를 전사체 양자 모두에 대해 사용하며, RNA 수준의 양적인 비교가 적절하여 초기 진단 비용을 절감시킬 것이다. 보다 더 큰 야생형에 대한 돌연변이형의 비율은 RNA 수준을 정량적으로 비교하든지 정성적으로 비교하든지간에 보다 더 높은 위험성과 상호 관련된다.In certain examples, ribozymes that were capable of cleaving only wild or mutant types of target RNA were used for analysis. The first ribozyme was used to identify the presence of wild-type RNA in the sample and the second ribozyme was used to identify the mutant RNA in the sample. As a response control, the cleavage of the synthetic substrates of wild-type and mutant RNA using both ribozymes demonstrated the relative efficiency of ribozymes in the reaction and the absence of "non-targeting" cleavage of RNA species. The cleavage product from the synthetic substrate contributed to the generation of size markers for analysis of wild type and mutant RNAs in the sample. As such, each assay required two ribozymes, two substrates, and one unknown sample bound in six reactions. The presence of the cleavage product can be determined using RNase analysis, as a result of which the full length and cleavage fragments of each RNA can be analyzed in one lane of polyacrylamide gel. There is no absolute need to quantify these results to gain insight into the expression of mutant RNAs and the potential risk of desired phenotypic transformation in target cells. The expression of mRNA whose protein product was involved in the development of the phenotype (ie HCV) was appropriate for establishing the trial. Comparable specific activity probes are used for both transcripts, and quantitative comparisons of RNA levels will be appropriate to reduce initial diagnostic costs. The ratio of mutants to larger wildtypes correlates with higher risk, whether quantitatively or qualitatively comparing RNA levels.

추가의 용도Additional uses

본 발명의 서열 특이적 효소성 핵산 분자의 잠재적 유용성은 RNA의 연구에 있어서 DNA 엔도누클레아제 제한효소가 DNA의 연구에서 가지는 것과 많은 점에서 동일하다(Nathans et al., 1975 Ann. Rev. Biochem. 44:273). 예를 들어, 제한 단편의 패턴은 두개의 관련된 RNAs 사이의 서열 관련성을 설정하는데 사용될 수 있으며, 커다란 RNAs는 연구에 보다 더 유용한 크기의 단편으로 절단될 수 있다. 리보자임의 서열 특이성의 조작 가능성은 미지의 서열의 RNAs의 절단에 대해 적합하다.The potential utility of the sequence specific enzymatic nucleic acid molecules of the present invention is the same in many respects to that of DNA endonuclease restriction enzymes in the study of RNA in the study of RNA (Nathans et al., 1975 Ann. Rev. Biochem). 44: 273). For example, the pattern of restriction fragments can be used to establish sequence relationships between two related RNAs, and large RNAs can be cut into fragments of a size more useful for the study. The operability of the sequence specificity of ribozymes is suitable for cleavage of RNAs of unknown sequences.

다른 구체예는 하기 청구범위내에 있다.Other embodiments are within the scope of the following claims.

표 1Table 1

천연 리보자임의 성질Nature of Natural Ribozyme

Ⅰ군 인트론Ⅰ group intron

- 크기: ∼150 내지 ＞1000 누클레오티드Size: -150 to> 1000 nucleotides

- 절단 부위의 5' 직후 표적 서열에 U를 필요로 함.Requiring U at the target sequence immediately 5 'of the cleavage site.

- 절단 부위의 5' 측면에서 4 내지 6개 누클레오티드를 결합함.Binding 4 to 6 nucleotides on the 5 'side of the cleavage site.

- 반응 메카니즘: 구아노신의 3'-OH를 공격하여 3'-OH 및 5'-구아노신을 가진 절단 산물을 생성함.Reaction mechanism: attacking the 3'-OH of guanosine to produce a cleavage product with 3'-OH and 5'-guanosine.

- 어떤 경우에는 폴딩 및 활성 구조의 유지를 보조하기 위해 추가적 단백질 보조인자가 요구됨.In some cases additional protein cofactors are required to aid folding and maintenance of the active structure.

- 이 종류의 것으로 300여개가 공지됨. 테트라히메나 터모필라(Tetrahymena thermophila) RNA, 진균성 미토콘드리아, 엽록체, 파지 T4, 청-녹 조류 등에서 개재 서열이 발견됨 .About 300 of this kind are known. Intervention sequences are found in Tetrarhymena thermophila RNA, fungal mitochondria, chloroplasts, phage T4, and blue-green algae.

- 주된 구조적 특징은 주로 계통발생학적 비교, 변이형성, 및 생화학적 연구를 통하여 주로 확립됨[1,2].The main structural features are mainly established through phylogenetic comparisons, mutagenesis, and biochemical studies [1, 2].

- 하나의 리보자임에 대하여 완전한 속도론적 체계가 확립됨[3,4,5,6].A complete kinetic system is established for one ribozyme [3, 4, 5, 6].

- 리보자임 폴딩 및 기질 도킹의 연구는 진행중임[7,8,9].-Studies of ribozyme folding and substrate docking are ongoing [7, 8, 9].

- 중요한 나머지의 화학적 변형 조사는 잘 확립되어 있음[10,11].Investigations of chemical modifications of the critical remainder are well established [10, 11].

- 작은(4 내지 6nt) 결합 부위는 이러한 리보자임을 비특이적으로 만들어 표적 RNA를 절단할 수 없으나, 테트라히메나 Ⅰ군 인트론은 손상된 메시지로 새로운 β-갈락토시다제 서열의 결합에 의해 "손상된" β-갈락토시다제 메시지를 회복시키는데 사용되었다[12].Small (4-6 nt) binding sites can not cleave target RNA by making these ribozymes nonspecific, but tetrahimena group I introns are damaged messages that are "damaged" by binding of new β-galactosidase sequences -Was used to recover galactosidase messages [12].

RN아제P RNA(M1 RNA)RNase P RNA (M1 RNA)

- 크기: ∼290 내지 400개 누클레오티드Sizes: 290-400 nucleotides

- 편재하는 리보누클레오티드 효소의 RNA 부분RNA portion of the ubiquitous ribonuclease enzyme

- tRNA 전구체를 절단하여 성숙한 tRNA를 형성한다[13].cleaving tRNA precursors to form mature tRNAs [13].

- 반응 메카니즘: M2+-OH에 의한 공격으로 3'-OH 및 5'-인산기를 가진 절단 생성물을 생성가능.Reaction Mechanism: Attack with M2 + -OH can produce cleavage products with 3'-OH and 5'-phosphate groups.

- RN아제P는 원핵생물 및 진핵생물을 통하여 발견된다. RNA 서브단위는 세균, 효모, 설치류, 및 영장류로부터 서열화되었다.RNase P is found throughout prokaryotes and eukaryotes. RNA subunits were sequenced from bacteria, yeast, rodents, and primates.

- 치료적 용도로 내인성 RN아제P의 사용은 외부 가이드 서열(EGS)과 표적 RNA의 하이브리드화를 통하여 가능하다[14, 15].The use of endogenous RNase P for therapeutic use is possible through hybridization of an external guide sequence (EGS) with a target RNA [14, 15].

- 중요한 인산기 및 2'OH 접촉은 최근에 확인되었다[16,17]Important phosphate and 2'OH contacts have recently been identified [16,17].

Ⅱ군 인트론Group II Intron

- 크기: ＞1000누클레오티드Size:> 1000 nucleotides

- 표적 RNA를 트랜스 절단하는 것으로 최근 증명되었다[18,19]Recently demonstrated to trans-cut target RNA [18,19]

- 서열 조건은 완전히 결정되어 있지 않음Sequence conditions are not fully determined

- 반응 메카니즘: 내부 아데노신의 2'-OH는 3'-5' 및 2'-5' 분지 지점을 함유한 "래리엇(lariet)" RNA 및 3'-OH를 가진 절단 산물을 생성한다.Reaction Mechanism: 2'-OH of internal adenosine produces a cleavage product with "lariet" RNA and 3'-OH containing 3'-5 'and 2'-5' branching points.

- RNA 절단 및 결합 뿐만 아니라 DNA 절단[20,21]에 참여하는 것으로 증명된 유일한 천염 리보자임이다It is the only natural salt ribozyme that has been shown to participate in DNA cleavage [20,21] as well as RNA cleavage and binding.

- 주된 구조적 특징은 계통발생학적 비교를 통하여 주로 확립되어 있다[22]The main structural features are mainly established through phylogenetic comparisons [22].

- 중요한 2'OH 접촉이 초기에 확인됨[23]Significant 2'OH contact was initially identified [23]

- 속도론적 체계는 개발중임.Kinetic system is under development.

뉴로스포라(Neurospora) VS RNANeurospora VS RNA

- 크기: ∼144 누클레오티드Size: -144 nucleotides

- 표적 RNA를 트랜스 절단하는 것으로 최근 증명되었다[18,19]Recently demonstrated to trans-cut target RNA [18,19]

- 서열 조건은 완전히 결정되어 있지 않음Sequence conditions are not fully determined

- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.Reaction mechanism: 2'-OH 5 'attack on cleavable bonds results in cleavage products with 2', 3'-cyclic phosphoric acid and 5'-OH ends.

- 결합 부위 및 구조적 조건은 완전히 결정되어 있지 않음.Binding sites and structural conditions are not fully determined.

- 이러한 종류로서 1개만 공지되어 있음. 뉴로스포라(Neurospora) VS RNA에서 발견됨.Only one of these types is known. Found in Neurospora VS RNA.

해머헤드 리보자임Hammerhead Ribozyme

(참고문헌 참조)(See references)

- 크기: ∼ 23 내지 40 누클레오티드Size: from 23 to 40 nucleotides

- 절단 부위의 5'직후에 표적 서열 UH를 필요로 한다.The target sequence UH is required immediately after 5 ′ of the cleavage site.

- 절단 부위의 양쪽 측면에서 가변수의 누클레오티드와 결합한다Binds to variable nucleotides on both sides of the cleavage site

- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.Reaction mechanism: 2'-OH 5 'attack on cleavable bonds results in cleavage products with 2', 3'-cyclic phosphoric acid and 5'-OH ends.

- 이러한 종류로서 14개가 공지됨. 감염원으로서 RNA를 사용하는 많은 식물 병원체(바이러스형)에서 발견.14 known as this kind. Found in many plant pathogens (virus types) that use RNA as a source of infection.

- 필수 구조적 특징은 2개의 결정 구조를 포함하여 정의되어 있음[26,27]-Essential structural features are defined including two crystal structures [26, 27].

- 최소의 결합 활성이 증명됨(시험관내 선택을 통한 엔지니어링에 대하여)[28]Minimal binding activity is demonstrated (for engineering via in vitro selection) [28]

- 완전한 속도론적 체계는 2개 이상의 리보자임에 대하여 확립됨[29]A complete kinetic system is established for two or more ribozymes [29].

- 중요한 나머지의 화학적 변형 조사는 잘 확립되어 있음[30]Investigations of chemical modifications of the critical remainder are well established [30].

헤어핀 리보자임Hairpin Ribozyme

- 크기: ∼50 누클레오티드Size: -50 nucleotides

- 절단 부위 3'직후에 표적 서열 GUC를 필요로 한다.Target sequence GUC is required immediately after cleavage site 3 ′.

- 절단 부위의 5' 측면에서 4 내지 6개 누클레오티드 및 가변수를 절단 부위의 3'측면과 결합한다.-Combine 4-6 nucleotides and variables in the 5 'side of the cleavage site with the 3' side of the cleavage site.

- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.Reaction mechanism: 2'-OH 5 'attack on cleavable bonds results in cleavage products with 2', 3'-cyclic phosphoric acid and 5'-OH ends.

- 이 종류로서 3개가 공지되어 있음. 감염원으로서 RNA를 사용하는 3개의 식물 병원체(타바코 링스포트 바이러스(tabacco ringspot virus), 아라비스 모자이크 바이러스(arabis mosaic virus) 및 치코리 옐로우 모틀 바이러스(chicory yellow mottle virus)의 새틀라이트 RNA)에서 발견.-Three of these are known. Found in three plant pathogens that use RNA as infectious agent: satellite RNA of the tabacco ringspot virus, arabis mosaic virus and chicory yellow mottle virus.

- 필수 구조적 특징은 정의되어 있음[31, 32,33,34]-Required structural features are defined [31, 32, 33, 34]

- 결합 활성(절단 활성에 부가하여)은 리보자임이 시험관내 선택을 통한 엔지니어링될 수있도록 한다.Binding activity (in addition to cleavage activity) allows ribozymes to be engineered through in vitro selection.

- 완전한 속도론적 체계는 1개의 리보자임에 대하여 확립됨[36]A complete kinetic system is established for one ribozyme [36].

- 중요한 나머지의 화학적 변형 조사가 시작되었다[37,38]Investigation of the chemical modifications of the critical remainder [37,38]

델타 간염 바이러스(HDV) 리보자임Delta hepatitis virus (HDV) ribozyme

- 크기: ∼60 누클레오티드Size: ˜60 nucleotides

- 표적 RNA의 트랜스 절단이 증명됨[39]-Trans truncation of target RNA has been demonstrated [39]

- 절단 부위의 5' 서열이 요구되지 않지만, 결합 부위 및 구조적 조건은 완전히 결정되지 않음[40]5 'sequence of cleavage site is not required, but binding site and structural conditions are not fully determined [40]

- 반응 메카니즘: 절단가능 결합에 2'-OH 5' 공격으로 2',3'-사이클릭 인산 및 5'-OH 말단을 가진 절단 산물을 생성한다.Reaction mechanism: 2'-OH 5 'attack on cleavable bonds results in cleavage products with 2', 3'-cyclic phosphoric acid and 5'-OH ends.

- 이 종류로서 2개만이 공지됨, 인간 HDV에서 발견.Only two are known as this type, found in human HDV.

- HDV의 순환 형태는 활성이고 증가된 누클레아제 안정성을 나타낸다[41].The circulating form of HDV is active and shows increased nuclease stability [41].

참고문헌references

Claims (50)

C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 상기 효소적 핵산 분자가 해머헤드 모티프상태이고, 효소적 핵산 분자의 결합 아암(arm)이 표 Ⅳ 내지 Ⅵ 및 Ⅷ에 정의된 기질 서열중 어느 하나에 상보적인 서열을 포함하는 효소적 핵산 분자.In an enzymatic nucleic acid molecule that specifically cleaves RNA derived from hepatitis C virus (HCV), the enzymatic nucleic acid molecule is in the form of a hammerhead motif and the binding arms of the enzymatic nucleic acid molecule are shown in Table IV. An enzymatic nucleic acid molecule comprising a sequence complementary to any of the substrate sequences defined in VI and VII. C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 상기 효소적 핵산 분자가 헤어핀 모티프상태이고, 효소적 핵산 분자의 결합 아암(arm)이 표 Ⅶ에 정의된 기질 서열중 어느 하나에 상보적인 서열을 포함하는 것을 특징으로 하는 효소적 핵산 분자.In an enzymatic nucleic acid molecule that specifically cleaves RNA derived from hepatitis C virus (HCV), the enzymatic nucleic acid molecule is in the form of a hairpin motif, and the binding arm of the enzymatic nucleic acid molecule is defined in Table VII. An enzymatic nucleic acid molecule comprising a sequence complementary to any one of the substrate sequences. 제 1항에 있어서, 효소적 핵산 분자가 2개 염기쌍 이상의 길이의 스템 Ⅱ 영역을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The enzymatic nucleic acid molecule of claim 1, wherein the enzymatic nucleic acid molecule comprises a stem II region of length of at least two base pairs. 제 1항 또는 제 2항에 있어서, 핵산이 RNA에 상보적인 12 내지 100개 염기를 포함하는 것을 특징으로 하는 효소적 핵산 분자.3. Enzymatic nucleic acid molecule according to claim 1, wherein the nucleic acid comprises 12 to 100 bases complementary to RNA. 4. 제 1항 또는 제 2항에 있어서, 핵산이 mRNA에 상보적인 14 내지 24개 염기를 포함하는 것을 특징으로 하는 효소적 핵산 분자.3. Enzymatic nucleic acid molecule according to claim 1 or 2, wherein the nucleic acid comprises 14 to 24 bases complementary to the mRNA. 제 2항에 있어서, 효소적 핵산 분자가 3 내지 7개 염기쌍의 길이의 스템 Ⅱ 영역을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The enzymatic nucleic acid molecule of claim 2, wherein the enzymatic nucleic acid molecule comprises a Stem II region of 3 to 7 base pairs in length. 제 2항에 있어서, 효소적 핵산 분자가 표 Ⅶ에 정의된 리보자임 서열중 너으 하나를 주성분으로 포함하는 것을 특징으로 하는 효소적 핵산 분자.The enzymatic nucleic acid molecule of claim 2, wherein the enzymatic nucleic acid molecule comprises as its main component one of the ribozyme sequences defined in Table VII. 제 1항에 있어서, 효소적 핵산 분자가 표 Ⅳ 내지 Ⅵ 및 Ⅶ에 정의된 리보자임 서열중 어느 하나를 주성분으로 포함하는 것을 특징으로 하는 효소적 핵산 분자.2. The enzymatic nucleic acid molecule according to claim 1, wherein the enzymatic nucleic acid molecule comprises as a main component any one of the ribozyme sequences defined in Tables IV to VI and VIII. 제 1항 또는 제 2항의 효소적 핵산 분자를 포함하는 약학 조성물.A pharmaceutical composition comprising the enzymatic nucleic acid molecule of claim 1. 제 1항 또는 제 2항중 어느 하나의 효소적 핵산 분자를 포함하는 포유동물 세포.A mammalian cell comprising the enzymatic nucleic acid molecule of claim 1. 제 10항에 있어서, 포유동물 세포가 인간 세포인 것을 특징으로 하는 포유동물 세포.The mammalian cell of claim 10, wherein the mammalian cell is a human cell. 제 1항 또는 제 2항의 효소적 핵산 분자 1개 이상을 엔코딩하는 핵산 서열을 포함하여, 효소적 핵산 분자의 발현을 허용하는 발현 벡터.An expression vector that permits expression of an enzymatic nucleic acid molecule, comprising a nucleic acid sequence encoding at least one enzymatic nucleic acid molecule of claim 1. 제 12항의 발현 벡터를 포함하는 포유동물 세포.A mammalian cell comprising the expression vector of claim 12. 제 13항에 있어서, 포유동물 세포가 인간 세포인 것을 특징으로 하는 포유동물 세포.The mammalian cell of claim 13, wherein the mammalian cell is a human cell. 치료에 적당한 조건하에서 제 1항 또는 제 2항의 효소적 핵산 분자를 환자에게 투여하는 단계를 포함하는, 간경변, 간 부전 또는 간세포 암종의 치료 방법.A method of treating cirrhosis, liver failure or hepatocellular carcinoma, comprising administering to a patient the enzymatic nucleic acid molecule of claim 1 under conditions suitable for treatment. 치료에 적당한 조건하에서 제 1항 또는 제 2항의 발현 벡터를 환자에게 투여하는 단계를 포함하는, 간경변, 간 부전 및/또는 간세포 암종의 치료 방법.A method of treating cirrhosis, hepatic insufficiency and / or hepatocellular carcinoma, comprising administering to a patient the expression vector of claim 1 under conditions suitable for treatment. 환자의 세포를 제 1항 또는 제 2항의 핵산 분자와 접촉시키는 것을 포함하고, 치료에 적당한 조건하에서 하나 이상의 약물 요법을 사용하는 것을 추가로 포함하는, HCV와 관련된 질환을 가진 환자의 치료 방법.A method of treating a patient with a disease associated with HCV, comprising contacting a cell of the patient with the nucleic acid molecule of claim 1, further comprising using one or more drug therapies under conditions suitable for treatment. 제 1항에 있어서, 핵산이 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산의 4번 위치에서 2'-C-알릴 변형을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The method of claim 1 wherein the nucleic acid comprises at least 5 ribose residues, comprises phosphorothioate linkages at at least 3 5 ′ terminal nucleotides, and comprises a 2′-C-allyl modification at position 4 of the nucleic acid; , An enzymatic nucleic acid molecule comprising at least 10 2′-O-methyl modifications and comprising 3′-terminal modifications. 제 18항에 있어서, 핵산 분자가 3'말단에서 3'-3' 결합된 역위된 비염기성 부분을 포함하는 것을 특징으로 하는 효소적 핵산 분자.19. The enzymatic nucleic acid molecule of claim 18, wherein the nucleic acid molecule comprises an inverted non-basic moiety linked 3'-3 'at the 3' end. 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 2'-아미노 변형을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The nucleic acid molecule of claim 1, wherein the nucleic acid molecule comprises at least 5 ribose residues, comprises phosphorothioate linkages at at least 3 5 ′ terminal nucleotides, and is 2 ′ at position 4 and / or position 7 of the nucleic acid molecule. An enzymatic nucleic acid molecule comprising an amino modification, at least 10 2'-0-methyl modifications, and comprising a 3 'terminal modification. 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 비염기성 치환을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The nucleic acid molecule of claim 1, wherein the nucleic acid molecule comprises at least five ribose residues, comprises phosphorothioate linkages at three or more 5 ′ terminal nucleotides, and is nonbasic at positions 4 and / or 7 of the nucleic acid molecule. An enzymatic nucleic acid molecule comprising a substitution, at least 10 2′-O-methyl modifications, and comprising a 3 ′ terminal modification. 제 1항에 있어서, 핵산 분자가 5개 이상의 리보오스 잔기를 포함하고, 3개 이상의 5' 말단 누클레오티드에서 포스포로티오에이트 결합을 포함하며, 핵산 분자의 4번 위치 및/또는 7번 위치에서 6-메틸 우리딘 치환을 포함하고, 10개 이상의 2'-O-메틸 변형을 포함하며, 3'말단 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.The nucleic acid molecule of claim 1, wherein the nucleic acid molecule comprises at least five ribose residues, comprises phosphorothioate linkages at three or more 5 ′ terminal nucleotides, and is located at 6-position at position 4 and / or 7 of the nucleic acid molecule. An enzymatic nucleic acid molecule comprising a methyl uridine substitution, comprising at least 10 2′-O-methyl modifications, and comprising a 3 ′ terminal modification. 억제에 적당한 조건하에서 제 1항 또는 제 2항의 효소적 핵산 분자를 포유 동물 세포에 투여하는 단계를 포함하는 포유동물 세포에서 HCV 복제를 억제시키는 방법.A method of inhibiting HCV replication in a mammalian cell comprising administering to the mammalian cell the enzymatic nucleic acid molecule of claim 1 under conditions suitable for inhibition. 제 1항 또는 제 2항의 효소적 핵산 분자를, 별개의 RNA 분자의 절단에 적당한 조건하에서 별개의 RNA 분자와 접촉시키는 것을 포함하는 별개의 RNA 분자를 절단시키는 방법.A method of cleaving a separate RNA molecule comprising contacting the enzymatic nucleic acid molecule of claim 1 with a separate RNA molecule under conditions suitable for cleavage of the separate RNA molecule. 제 24항에 있어서, 절단이 2가 양이온의 존재하에서 수행되는 것을 특징으로 하는 방법.The method of claim 24, wherein the cleavage is performed in the presence of a divalent cation. 제 25항에 있어서, 2가 양이온이 Mg2+인 것을 특징으로 하는 방법.The method of claim 25, wherein the divalent cation is Mg 2+ . 제 1항 또는 제 2항에 있어서, 핵산이 화학적으로 합성되는 것을 특징으로 하는 핵산 분자.The nucleic acid molecule of claim 1 or 2, wherein the nucleic acid is chemically synthesized. 재 12항에 있어서, 벡터가The method of claim 12 wherein the vector is a) 전사 개시 영역;a) transcription initiation region; b) 전사 종결 영역;b) transcription termination region; c) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,c) a gene encoding one or more nucleic acid molecules, 상기 유전자는 개시 영역 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.Said gene is operably linked with an initiation region and a termination region, thereby allowing expression and / or delivery of nucleic acid molecules. 제 12항에 있어서, 벡터가The method of claim 12 wherein the vector is a) 전사 개시 영역;a) transcription initiation region; b) 전사 종결 영역;b) transcription termination region; c) 개방 해독 프레임;c) an open reading frame; d) 상기 개방 해독 프레임의 3'-말단과 작동적으로 연결된, 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,d) a gene encoding one or more nucleic acid molecules operably linked with the 3′-end of the open reading frame, 상기 유전자는 개시 영역, 개방 해독 프레임 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.Said gene is operatively associated with an initiation region, an open reading frame and a termination region, thereby allowing expression and / or delivery of nucleic acid molecules. 제 12항에 있어서, 벡터가The method of claim 12 wherein the vector is a) 전사 개시 영역;a) transcription initiation region; b) 전사 종결 영역;b) transcription termination region; c) 인트론;c) introns; d) 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,d) a gene encoding one or more nucleic acid molecules, 상기 유전자는 개시 영역, 인트론 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.Said gene is operatively associated with the initiation region, intron and termination region, thereby allowing expression and / or delivery of the nucleic acid molecule. 제 12항에 있어서, 벡터가The method of claim 12 wherein the vector is a) 전사 개시 영역;a) transcription initiation region; b) 전사 종결 영역;b) transcription termination region; c) 인트론c) intron d) 개방 해독 프레임;d) an open reading frame; e) 상기 개방 해독 프레임의 3'-말단과 작동적으로 연결된, 하나 이상의 핵산 분자를 엔코딩하는 유전자를 포함하며,e) a gene encoding one or more nucleic acid molecules operably linked with the 3'-end of said open reading frame, 상기 유전자는 개시 영역, 인트론, 개방 해독 프레임 및 종결 영역과 작동적으로 결합되어, 핵산 분자의 발현 및/또는 전달을 허용하는 것을 특징으로 하는 발현 벡터.Said gene is operatively associated with an initiation region, an intron, an open reading frame and a termination region, thereby allowing expression and / or delivery of the nucleic acid molecule. C형 간염 바이러스(HCV)로부터 유도된 RNA를 특이적으로 절단시키는 효소적 핵산 분자에 있어서, 효소적 핵산 분자가 DNA 효소인 것을 특징으로 하는 효소적 핵산 분자.An enzymatic nucleic acid molecule that specifically cleaves RNA derived from hepatitis C virus (HCV), wherein the enzymatic nucleic acid molecule is a DNA enzyme. 제 1항, 제 2항 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산 분자가 하나 이상의 2'-당 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.33. The enzymatic nucleic acid molecule according to any one of claims 1, 2 and 32, wherein the enzymatic nucleic acid molecule comprises one or more 2'-sugar modifications. 제 1항, 제 2항, 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산이 하나 이상의 핵산 염기 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.33. The enzymatic nucleic acid molecule according to any one of claims 1, 2, and 32, wherein the enzymatic nucleic acid comprises one or more nucleic acid base modifications. 제 1항, 제 2항, 및 제 32항 중 어느 한 항에 있어서, 효소적 핵산 분자이 하나 이상의 포스포로티오에이트 변형을 포함하는 것을 특징으로 하는 효소적 핵산 분자.33. The enzymatic nucleic acid molecule of any one of claims 1, 2, and 32 wherein the enzymatic nucleic acid molecule comprises one or more phosphorothioate modifications. 제 17항에 있어서, 약물 요법이 타입 Ⅰ 인터페론인 것을 특징으로 하는 방법.18. The method of claim 17, wherein the drug therapy is type I interferon. 제 36항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 동시에 투여되는 것을 특징으로 하는 방법.The method of claim 36, wherein the Type I interferon and the enzymatic nucleic acid molecule are administered simultaneously. 제 36항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 개별적으로 투여되는 것을 특징으로 하는 방법.The method of claim 36, wherein the Type I interferon and the enzymatic nucleic acid molecule are administered separately. 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 알파인 것을 특징으로 하는 방법.37. The method of claim 36, wherein the Type I interferon is interferon alpha. 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 베타인 것을 특징으로 하는 방법.37. The method of claim 36, wherein the Type I interferon is interferon beta. 제 36항에 있어서, 타입 Ⅰ 인터페론이 인터페론 감마인 것을 특징으로 하는 방법.37. The method of claim 36, wherein the Type I interferon is interferon gamma. 제 36항에 있어서, 타입 Ⅰ 인터페론이 콘센서스 인터페론인 것을 특징으로 하는 방법.37. The method of claim 36, wherein the Type I interferon is consensus interferon. 환자의 세포를 제 32항의 핵산 분자와 접촉시키는 것을 포함하고, 치료에 적당한 조건하에서 하나 이상의 약물 요법을 사용하는 것을 추가로 포함하는, HCV와 관련된 질환을 가진 환자의 치료 방법.A method of treating a patient with a disease associated with HCV, comprising contacting the patient's cells with the nucleic acid molecule of claim 32, further comprising using one or more drug therapies under conditions suitable for treatment. 제 43항에 있어서, 약물 요법이 타입 Ⅰ 인터페론인 것을 특징으로 하는 방법.44. The method of claim 43, wherein the drug therapy is type I interferon. 제 44항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 동시에 투여되는 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon and the enzymatic nucleic acid molecule are administered simultaneously. 제 44항에 있어서, 타입 Ⅰ 인터페론 및 효소적 핵산 분자가 개별적으로 투여되는 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon and the enzymatic nucleic acid molecules are administered separately. 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 알파인 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon is interferon alpha. 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 베타인 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon is interferon beta. 제 44항에 있어서, 타입 Ⅰ 인터페론이 인터페론 감마인 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon is interferon gamma. 제 44항에 있어서, 타입 Ⅰ 인터페론이 콘센서스 인터페론인 것을 특징으로 하는 방법.45. The method of claim 44, wherein the Type I interferon is consensus interferon.
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