KR20010012848A - Compositions containing select solid polyol fatty acid polyesters - Google Patents

Abstract

Topical to human hair or skin containing a combination of a solid polyol fatty acid polyester having a melting point of about 30 ° C. to about 80 ° C. and a liquid oil other than a solid polyol fatty acid polyester having a melting point of about 30 ° C. to less than about −30 ° C. Compositions suitable for application are described, wherein the solid polyol fatty acid polyesters contain one polyol moiety and at least one fatty acid moiety, wherein the polyol moiety has at least 4 hydroxyl groups, and of these free hydroxyl groups At least 60% is esterified by at least one fatty acid moiety having 8 to 22 carbon atoms. The composition preferably further contains a topical carrier for blending the liquid polyol fatty acid polyester with a solid oil. This composition provides potent softening and aesthetic benefits.

Description

COMPOSITIONS CONTAINING SELECT SOLID POLYOL FATTY ACID POLYESTERS}

Topical compositions containing emollients have been used for many years in the treatment of human hair or skin. For example, occluded hydrocarbons such as petrolatum have been used as topical softeners to provide a protective film to human skin to prevent loss of moisture to the environment. Petrolatum has also been used in hair care products such as conditioners and grooming aids.

However, the most effective and widely used compositions containing occlusion softeners are of poor aesthetic quality such as shine and stickiness. Moreover, some occlusion softeners used to provide a protective film on the skin can clog pores and block the flow of oxygen. Such obstruction of the skin surface or obstruction of the flow or circulation of air and moisture limits the use of the heavy occlusion softener material. In addition, European Patent Publication No. 458,600 B1 (March 2, 1994) describes occluded skin care compositions containing one polyol fatty acid polyester having at least four free hydroxyl groups. At least 60% is esterified by one or more fatty acids containing 8 to 22 carbon atoms that can form a blockage on the skin after topical application. U.S. Pat. No. 5,160,738, issued Nov. 3, 1992 to Macaulay et al., Describes occlusion compositions containing a mixture of two or more polyol fatty acid polyesters having the same appearance and physical properties as petrolatum. However, these compositions also have the disadvantage of being heavy and can clog pores to block the flow of oxygen.

It has now been found that formulations containing occlusive softeners, which are not heavy, sticky or greasy, can be formulated. These compositions contain a selected blend of solid polyol fatty acid polyesters having a melting point of about 30 ° C. to about 80 ° C. and liquid oils having a melting point of about 30 ° C. to less than about −30 ° C., which compositions combine both efficacy and aesthetic benefits. Applicable to various products to provide.

Therefore, it is an object of the present invention to provide a composition which has both an effective softening property and an acceptable aesthetic quality and contains a occlusive softener used in combination with a liquid oil. Another object of the present invention is to provide a topical composition containing a polyol fatty acid polyester that is heavy, sticky, non-greasy and effective for the treatment of human hair or skin.

[Overview of invention]

The present invention relates to a human hair comprising a combination of a solid polyol fatty acid polyester having a melting point of about 30 ° C. to about 80 ° C. and a liquid oil other than a liquid polyol fatty acid polyester having a melting point of about 30 ° C. to less than about −30 ° C. Or a composition suitable for topical application to the skin, wherein said solid polyol fatty acid polyester contains one polyol moiety and at least one fatty acid moiety, said polyol moiety having at least 4 free hydroxyl groups, these free At least 60% of the hydroxyl groups are esterified by at least one fatty acid moiety having 8 to 22 carbon atoms. The composition preferably further contains a topical carrier for the combination of the solid polyol fatty acid polyester and the liquid oil.

All percentages and ratios used in the present invention are expressed in weight, and all measurements were performed at 25 ° C., otherwise indicated separately. The present invention may contain, but may consist of or consist essentially of the necessary ingredients as well as the optional ingredients and the components described below.

The invention is topical to human hair or skin, comprising a selected blend of solid polyol fatty acid polyesters having a melting point of about 30 ° C. to about 80 ° C. and liquid oils having a melting point of about 30 ° C. to less than about −30 ° C. To compositions suitable for application.

The term "topical composition" as used herein means a composition suitable for topical application to human hair or skin. The term is used to encompass various appearance care, beauty care and cosmetic compositions. Examples of topical compositions include lotions, creams, hand and body lotions, skin conditioning lotions and creams, skin care compositions, sunscreen compositions, cold creams, anti-acne compositions, skin regeneration products, non-foaming cleansing lotions, moisturizers, facial moisturizers, Makeup products, foundations, lipsticks, lip protectors, skin cleansers, hands, face and body cleansers, shower products, shampoos, and the like.

As used herein, the term "topical carrier" is well known to those skilled in the art and means one or more compatible solid or liquid fillers, diluents or excipients suitable for administration to humans. As used herein, the term "compatibility" means that the components of the topical carrier may be mixed with the components of the present invention in a non-interacting manner that may substantially reduce the efficacy or aesthetic properties of the cosmetic composition under normal conditions of use. It also means that can be mixed with each other. Topical carriers should be pharmaceutically acceptable carriers. As used herein, the term "pharmaceutically acceptable" means that the topical carrier should be sufficiently pure and suitable for use in contact with human hair or skin without severe toxicity, incompatibility, instability, allergic reactions, etc. Means that.

Melting points of solid polyol fatty acid polyesters and liquid oils can be measured using conventional techniques. These techniques are well defined in the art and include thermometry and calorimetry. Particularly preferred techniques for melting point determination are described in US Pat. No. 5,306,514 to Letton et al., April 26, 1994, incorporated herein by reference in its entirety. This technique typically involves measuring the melting point using differential scanning calorimetry (DSC), which measures the melting point using a scanning temperature of 5 ° C./min. The melting point is the temperature at the intersection of a baseline, i.e., a particular hot wire and a line in contact with the trailing edge of the endothermic peak.

Solid polyol fatty acid polyester

The composition of the present invention is about 0.1% to about 99.9% by weight of the composition, preferably about 0.5% to about 75% by weight, more preferably about 1% to about 50% by weight, even more preferably From about 2% to about 25% by weight solid polyol fatty acid polyester. This solid polyol fatty acid polyester has a melting point of about 30 ° C. to about 80 ° C. and is derived from any aliphatic or aromatic polyol having four or more free hydroxyl groups, wherein at least 60% of these free hydroxyl groups have 8 to 8 carbon atoms. Subsequently esterified by one or more fatty acids of 22. Fatty acids can also be described as carboxylic acids, since the terms fatty acid and carboxylic acid are often used interchangeably with those skilled in the art.

Solid polyol polyesters used in the present invention are polyol esters or polyesters in which the fatty acid ester groups of the polyester contain the following combinations, and the ratio of (a) to (b) is from about 1 to 15 to about 2 to 1: (a) a long chain unsaturated fatty acid moiety or a mixture of a long chain unsaturated fatty acid moiety and a short chain saturated fatty acid moiety and (b) a long chain saturated fatty acid moiety. At least about 15%, preferably at least about 30%, more preferably at least about 50%, and most preferably at least about 60% by weight of the total fatty acid portion of the polyester is C ₂₀ or more saturated fatty acid portion. to be. The long chain unsaturated fatty acid moiety is typically straight chain and has a carbon number of at least about 12, preferably from about 12 to about 22, more preferably from about 18 to about 22. Most preferred unsaturated fatty acids are C ₁₈ mono and / or di unsaturated fatty acids. Short-chain saturated fatty acids are typically unbranched and have a carbon number of about 2 to about 12, preferably about 6 to about 12, most preferably about 8 to about 12. Long chain saturated fatty acids are typically straight chain and have a carbon number of at least about 20, preferably from about 20 to about 22, most preferably about 22. The molar ratio of the group (a) fatty acid moiety to the group (b) fatty acid moiety in the polyester molecule is about 1:15 to about 2: 1, preferably about 1: 7 to about 5: 3, more preferably about 1: 7 to about 3: 5. The average degree of esterification of these fatty acid esters causes at least about 60% of the hydroxyl groups of the polyol to be esterified. In the case of sucrose polyesters, it is preferred that about 7 to about 8 of the hydroxyl groups of the polyol are esterified. Typically, the hydroxyl groups of the polyol that are substantially whole, for example at least about 85%, preferably at least about 95%, are esterified.

Preferred polyols of solid polyol fatty acid esters are sugars comprising monosaccharides, disaccharides and trisaccharides containing from about 4 to about 11 hydroxyl groups. Most preferred sugars are sugars containing about 4 to about 8, more preferably about 6 to about 8 hydroxyl groups. Examples of polyols containing four hydroxyl groups are monosaccharide xylose, arabinose and combinations thereof. Suitable examples of polyols containing five hydroxyl groups are monosaccharide galactose, fructose, mannose, glucose and combinations thereof. Examples of disaccharide polyols that may be used include maltose, lactose, sucrose and combinations thereof, all of which contain eight hydroxyl groups. Preferred polyols are sucrose.

Examples of long-chain unsaturated fatty acid moieties include laurolate, myristoleate, palmitoleate, oleate, ellidate, erucate, linoleate, linoleate, arachidonate, eicosapentaenoate and docosa Hexaenoate is included, but is not limited thereto. For oxidative stability, mono and diunsaturated fatty acid moieties are preferred.

Examples of suitable short chain saturated fatty acid moieties include, but are not limited to, acetate, caproate, caprylate, caprate and laurate.

Examples of suitable long chain saturated fatty acid moieties include, but are not limited to, arachidate, behenate, lignokerate and serotate.

Of course, the long chain unsaturated fatty acid moieties may be used alone or in admixture with each other, or in any proportion with the short chain saturated fatty acid moieties. Similarly, long chain saturated fatty acid moieties can be used in combination with one another in all proportions. The mixed fatty acid moiety of the raw oil containing a significant amount of the desired unsaturated or saturated acid can be used as the acid moiety for preparing the compounds for use in the present invention. The mixed fatty acid portion of the oil should contain at least about 30%, preferably at least about 50%, most preferably at least about 80% of the desired unsaturated or saturated acid. For example, rapeseed oil fatty acid or soybean oil fatty acid may be used in place of pure C ₁₂ -C ₁₆ unsaturated fatty acids. Cured, ie hydrogenated higher eruk rapeseed oil fatty acids may be used in place of pure C ₂₀ -C ₂₂ saturated acids. Preferably, C ₂₀ and higher acids or derivatives thereof such as methyl or other lower alkyl esters are concentrated, for example by distillation. Fatty acids of palm kernal oil or coconut oil can be used as a raw material of C ₈ to C ₁₂ acids. One example of the use of raw oils to make solid polyol polyesters for use in the compositions of the present invention is the fatty acids of higher ole sunflower oils and the fatty acids of higher fully hydrogenated rapeseed oil of substantially fully hydrogenated oil. To prepare a solid sucrose polyester. If sucrose is substantially completely esterified with a 1: 3 weight ratio mixture of the methyl esters of the fatty acids of these two oils, the resulting sucrose polyester has a ratio of unsaturated C ₁₈ acid radicals to C ₂₀ and higher saturated acid radicals of about 1 : 1, and 28.6% by weight of the total fatty acids in the polyester will be C ₂₂ fatty acids.

The higher the ratio of the desired unsaturated and saturated acids in the fatty acid feedstock used to make the solid polyol polyester, the more effective the binding capacity of the ester with the liquid oil described below will be.

Examples of solid polyol fatty acid polyesters used in the compositions of the present invention include octaesters of raffinose wherein the esterified fatty acid moiety is a 1: 3 molar ratio of linoleate and behenate; Heptaester of maltose wherein the esterified fatty acid moiety is a 3: 4 molar ratio of sunflower seed oil fatty acid and lignokerate; Octaesters of sucrose, wherein the esterified fatty acid moiety is a 2: 6 molar ratio of oleate and behenate; And octaesters of sucrose, wherein the esterified fatty acid moiety is a 1: 3: 4 molar ratio of laurate, linoleate and behenate. Preferred materials are sucrose polyesters having a degree of esterification of 7-8 and fatty acid moieties of from 1: 7 to 3: 5 molar ratio (unsaturated: behen) C ₁₈ mono and / or diunsaturated and behene. Particularly preferred polyol esters are octaesters of sucrose with about 7 Behen fatty acid moieties and about 1 ole moiety present in the molecule.

Solid fatty acid polyesters in the present invention may be prepared according to conventional techniques for producing polyol polyesters. U.S. Patent 5,306,516, issued April 26, 1994 to Letton et al., Incorporated herein by reference in its entirety; U.S. Patent No. 5,306,515, issued April 26, 1994 to Letton et al .; U.S. Patent No. 5,306,514, issued April 26, 1994 to Letton et al .; U.S. Patent 4,797,300, issued Jan. 10, 1989 to Jandacek et al .; U.S. Patent No. 3,963,699, issued June 15, 1976 to Rizzi et al .; U.S. Patent 4,518,772, issued May 21, 1985 to Volpenhein et al .; And US Pat. No. 4,517,360, issued May 21, 1985 to Volpenhein et al.

Liquid oil

The compositions of the present invention contain liquid oils used in combination with the solid polyol fatty acid polyesters described herein. Liquid oils can be used as individual liquid oils or as a combination of liquid oils, and from about 0.1% to 99.9% by weight of the composition, preferably from about 0.5% to about 75% by weight, more preferably from about 1% by weight to And from about 2% to about 25% by weight even more preferably.

Liquid oils useful in the present invention have a melting point of less than 30 ° C., preferably from about 30 ° C. to less than about −30 ° C., more preferably from about 27.5 ° C. to less than about −30 ° C., even more preferably from about 25 ° C. to about A substance that is less than -30 ° C. Liquid oils generally have low solubility in water and are generally less than about 1 weight percent at 25 ° C. Examples of suitable liquid oils include, but are not limited to, mineral oils, hydrocarbons of about 5 to about 16 carbon atoms, fatty alcohol esters of about 3 to about 22 carbon atoms, fatty acid esters of about 3 to about 30 carbon atoms, vegetable oils, and mixtures thereof. It is not limited. Other oils suitable for use in the present invention are described in WO 95-00166 publication (January 5, 1995) to Gordon et al., Which is incorporated herein by reference in its entirety.

Mineral oils, also known as petrolatum liquids, are suitable for use in the present invention. This compound is a mixture of liquid hydrocarbons obtained from petrolatum. The Merck Index, 10th Edition, Entry 7048, p. 1033 (1983), and International Cosmetic Ingredient Dictionary, 5th Edition, Vol. 1, pp. 415-417 (1993), incorporated herein by reference in its entirety. See.

Suitable hydrocarbons for use in the present invention include straight and branched chain hydrocarbons having about 5 to about 16 carbon atoms. Hydrocarbon materials include, but are not limited to, dodecane, isododecane, hydrogenated polyisobutylene, hexadecane, isohexadecane (Permethyl® 101A, a hydrocarbon marketed by Presperse, South Plainfield, NJ) no. Also useful are C ₅ -C ₁₆ isoparaffins, which are C ₅ -C ₁₆ branched chain hydrocarbons.

Fatty alcohol esters suitable for use in the present invention include esters or diesters of fatty alcohols having from about 3 to about 22 carbon atoms. Fatty acid esters having about 3 to about 30 carbon atoms are also useful. Examples of this ester material include, but are not limited to, isopropyl myristate, isopropyl palmitate, isopropyl stearate, diisopropyl adipate and dioctyl sebacate (dioctyl ester of decandioic acid).

Vegetable oils that are liquid at ambient temperatures of about 20 ° C. to about 25 ° C. are also useful in the present invention. Examples of suitable vegetable oils include cod liver oil, dolphin oil, pork oil, carpenter oil, dolphin oil, seal oil, sperm whale oil, whale oil, acorn oil, almond oil, beech fruit oil, feng shui oil, rapeseed oil, Soybean oil, sunflower seed oil, groundnut oil, cottonseed oil, corn oil, safflower oil, olive oil, herring oil, sesame oil, castor oil, hazelnut oil, hemp seed oil, linseed oil, mustard (black) oil, neem oil , Peanut oil, pistachio fruit oil, poppy seed oil, pumpkin seed oil, tung oil, white mustard seed oil, pine oil, wheat germ oil, derivatives thereof and mixtures thereof.

Topical carriers

The composition of the present invention comprises from about 0.1% to about 99.9% by weight, preferably from about 50% to about 99% by weight, more preferably from about 60% to about 95% by weight of the solid polyol fatty acid polyester and liquid Topical carriers for combination with oils and topical carriers for any other component of the invention.

The combination of the solid polyol fatty acid polyester and liquid oil of the present invention is a cream, lotion, milk, gel, hand and body lotion, cold cream, non-foaming cleansing lotion, facial moisturizer, sunscreen, anti-acne preparation, topical analgesic It can be formulated into a variety of product forms, including mascara, lipstick, skin cleanser, hand, face and body cleanser, shower products, shampoos and the like. The carrier and any additional ingredients required to formulate such products depend on the product type and can be routinely selected by one of ordinary skill in the art.

Topical carriers can be in various forms. For example, emulsion carriers including oil-in-water, oil-in-water, oil-in-water, and silicon-in-oil emulsions are useful in the present invention, but are not limited thereto. These emulsions have a wide range of viscosities, for example from about 100 cps to about 200,000 cps. Other suitable topical carriers include anhydrous liquid solvents such as alcohols and silicones (eg, ethanol, isopropanol, dimethicone, cyclomethicone, etc.); Aqueous phase single phase liquid solvents (eg, hydro-alcoholic solvent systems); And those in which such anhydrous and aqueous based single phase solvents have been thickened (e.g., the viscosity of the solvent has been increased to such an extent that a suitable gum, resin, wax, polymer, salt, etc. is added to form a solid or semisolid). Included. Examples of topical carrier systems useful in the present invention are described in the following references incorporated herein by reference in their entirety: “Sun Products Formulary” Cosmetics & Toiletries, Vol. 105, pp. 122-139 (December 1990); "Sun Products Formulary", Cosmetics & Toiletries, Vol. 102, pp. 117-136 (March 1987); U.S. Patent No. 4,960,764, issued October 2, 1990 to Figueroa et al .; U.S. Patent 4,254,105, issued March 3, 1981 to Fukuda et al .; U.S. Patent No. 4,976,953, issued December 11, 1990 to Orr et al .; US Patent No. 5,073,372, issued December 17, 1991 to Turner et al .; U.S. Patent 5,585,104, issued December 17, 1996 to Ha et al .; U.S. Patent No. 5,607,678, issued March 4, 1997 to Moore, et al .; US Patent No. 5,607,980, issued March 4, 1997 to McAtee et al .; And US Pat. No. 5,618,522, issued April 8, 1997 to Kalea et al.

Topical carriers may also contain oil-in-water emulsion systems having complex structures such as liquid crystals and crystalline gel networks. The nature of the liquid crystal, the formulation of the liquid crystal and the properties and advantages of the liquid crystal are described in detail below, all of which are incorporated herein by reference in their entirety: G. Dahms, Properties of O / W Emulsions With Anisotropic Lameliar Phases, 101 Cosmetics & Toiletries, 113-115 (1986); P. Loll, Liquid Crystals in Cosmetic Emulsions, ICI Surfactants' Publication RP94-93E; And G M Eccleston, Multiple-Phase Oil-In-Water Emulsions, 41, J Soc Cosmet Chem, 1-22, (January / February 1990).

Additional ingredients

Various additional ingredients can be used in the compositions of the present invention. Examples include, but are not limited to:

Pharmaceutically active ingredients

The composition of the present invention may contain a safe effective amount of a pharmaceutically active ingredient. As used herein, the phrase "effective effective amount" is sufficient to modify the disease to be treated significantly or positively, but within a range of sound medical judgments that are small enough to avoid serious side effects (non-adequate benefit / risk). Means the amount of active ingredient. A safe and effective amount of a pharmaceutically active ingredient includes a particular active ingredient, the ability of the composition to permeate the active ingredient through the skin, the amount of the composition to be applied, the particular disease to be treated, the age and physical condition of the patient to be treated, the extent of the disease and the duration of treatment This will depend on factors such as the nature of the treatment and the nature of the accompanying treatment.

Pharmaceutically active ingredients that can be used in the compositions of the present invention are preferably from about 0.1% to about 20%, more preferably from about 0.1% to about 10%, most preferably about 0.1% by weight of the composition. To about 5% by weight. Mixtures of pharmaceutically active ingredients can also be used.

Examples of pharmaceutically active ingredients include, but are not limited to:

Pharmaceutically active ingredients useful in the compositions of the present invention include anti-acne preparations. Anti-acne preparations for use in the present invention include keratolytic agents such as salicylic acid, sulfur, lactic acid, glycolic acid, pyruvic acid, resorcinol and N-acetylcysteine; Retinoids such as retinoic acid and derivatives thereof (eg cis and trans); Antibiotics and antibacterial agents such as benzoyl peroxide, octopyrox, erythromycin, zinc, tetracycline, triclosan, azelaic acid and derivatives thereof, phenoxy ethanol and phenoxy propanol, ethyl acetate, clindamycin and meclocycline; Sebostats such as flavinoids; Alpha and beta hydroxy acids; And bile salts such as cymnol sulfate and derivatives thereof, deoxycholate and cholate. Preferred anti-acne active ingredients are those selected from the group consisting of salicylic acid, sulfur, resorcinol, lactic acid, zinc, erythromycin, benzoyl peroxide and mixtures thereof. Salicylic acid is more preferred.

Pharmaceutically active ingredients useful in the compositions of the present invention include nonsteroidal anti-inflammatory agents (NSAIDS). NSAIDS can be selected from the following categories: propionic acid derivatives; Acetic acid derivatives; Penamic acid derivatives; Biphenylcarboxylic acid derivatives; And oxycam. All NSAIDS are described in detail in US Pat. No. 4,985,459, issued January 15, 1991 to Sunshine et al., Incorporated herein by reference. Most preferred are aspirin, acetaminophen, ibuprofen, naproxen, venoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen (pirprofen), caprophene, oxaprozin, pranopropene, myroprofen, tioxaprofen, suprofen, aminopropene, thiapropene acid, fluprofen and bucloxane Propion NSAIDS containing, but not limited to. Also useful are steroidal anti-inflammatory agents containing hydrocortisone and the like.

Pharmaceutically active ingredients useful in the compositions of the present invention include antipruritic agents. Preferred antipruritic agents encompassed herein include pharmaceutically acceptable salts of metrelizine and trimetaprazine.

Pharmaceutically active ingredients useful in the compositions of the present invention include anesthetics. Preferred anesthetics included herein include lidocaine, bupivacaine, chlorprocaine, dibucaine, ethidocaine, mepivacaine, tetracaine, diclonin, hexylcaine, procaine, cocaine, ketamine, pramoxin and phenols. Pharmaceutically acceptable salts are included.

Pharmaceutically active ingredients useful in the compositions of the present invention include antibacterial agents (antibiotics, antifungal agents, probiotic and antiviral agents). Preferred antibacterial agents included herein include b-lactam preparations, quinolone preparations, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, triclosan, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxy Tetracycline, clindamycin, etabutol, metronidazole, pentamidine, gentamicin, kanamycin, linenemycin, metacycline, methenamin, minocycline, neomycin, netylmycin, paromomycin, streptomycin, tobramycin, mycomycin Pharmaceutically acceptable salts of nazol and amanfadine are included. Preferred antibacterial agents included here include tetracycline hydrochloride, erythromycin estoleate, erythromycin stearate (salt), amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate , Chlorhexidine Hydrochloride, Chlortetracycline Hydrochloride, Oxytetracycline Hydrochloride, Clindamycin Hydrochloride, Etambutol Hydrochloride, Metronidazole Hydrochloride, Pentamidine Hydrochloride, Gentamicin Sulfate, Carnamycin Sulfate Fate, Lineeomycin Hydrochloride, Metacycline Hydrochloride, Methenamin Hippurate, Methenamin Mandelate, Minosinline Hydrochloride, Neomycin Sulfate, Netylmycin Sulfate, Palomomycin Sulfate, Strepto Mycin sulfate, tobramai Shin sulfate, myconazole hydrochloride, amanpadin hydrochloride, amanpadin sulfate, triclosan, oxopyrox, parachloromethaxenol, nystatin, tolnaftate and clotrimazole.

Also useful here are sunscreens. Various types of sunscreens are disclosed in US Pat. No. 5,087,445, issued February 11, 1992 to Haffey et al .; U.S. Patent 5,073,372, issued December 17, 1991 to Turner et al .; US Patent No. 5,073,371, issued December 17, 1991 to Turner et al .; And Chapter VIII of Cosmetics Science and Technology, Segarin et al., Page 189, below, all of which are incorporated herein by reference in their entirety. Preferred among these sunscreen agents useful in the composition of the invention are 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenz Imidazole-5-sulfonic acid, octocrylene, oxybenzone, homomentyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3- Benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof.

Another useful sunscreen agent is U.S. Patent No. 4,937,370, issued June 26, 1990 to Sabatelli et al .; And US Pat. No. 4,999,186, issued March 12, 1991 to Sabatelli et al., Both of which are incorporated herein by reference in their entirety. Sunscreen agents described in these documents have, in a single molecule, two distinct chromophore moieties that exhibit different ultraviolet radiation absorption spectra. One chromophore portion absorbs mainly in the UVB radiation range and the other absorbs strongly in the UVA radiation range. These sunscreens provide higher efficacy, wider UV absorption, lower skin penetration and longer lasting efficacy than conventional sunscreens. Particularly preferred examples of such sunscreens include 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N with 4-hydroxydibenzoylmethane -(2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4- 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of (2-hydroxyethoxy) dibenzoylmethane, and mixtures thereof.

Generally, the composition may contain from about 0.5% to about 20% of the sunscreen useful in the present invention. The exact amount will depend on the sunscreen chosen and the desired sunscreen index (SPF). SPF is a commonly used measure of photoprotection of sun protection against erythema. See Federal Register, Vol. 43, No. 166, pp. 38206-38269, Aug. 25, 1978, which is hereby incorporated by reference in its entirety.

Daylight tanning, including dihydroxyacetone, glyceraldehyde, indole, derivatives thereof, and the like, is also useful in the compositions of the present invention. This sunless tanning agent can also be used in combination with a sunscreen agent.

Still other useful active ingredients include, but are not limited to, skin bleaching (or bleaching) agents including hydroquinone, ascorbic acid, kojic acid, and sodium metadisulfite.

Humectants and moisturizers

The compositions of the present invention may also contain one or more additional wet or moisturizing materials in addition to those described herein. Various wet and moisturizing materials can be used, each of from about 0.1% to about 20% by weight of the composition, more preferably from about 1% to about 10% by weight, most preferably from 2% to 5% by weight. May exist at the level. These substances include guanidines; Glycolic acid and glycolate (eg, ammonium and quaternary alkyl ammonium); Lactic acid and lactates (eg, ammonium and quaternary alkyl ammonium); Aloe vera in any of its various forms (eg, aloe vera gel); Polyhydroxy alcohols such as sorbitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; Polyethylene glycol; Sugars and starches; Sugar and starch derivatives (eg, alkoxylated glucose); Hyaluronic acid; Lactamide monoethanolamine; Acetamide monoethanolamine; And mixtures thereof.

Emulsifier

The composition of the present invention may contain various emulsifiers. These emulsifiers are useful for emulsifying the various carrier components of the compositions of the present invention. Suitable emulsifiers can include any of a variety of nonionic, cationic, anionic and zwitterionic emulsifiers, described in priority and other references. Published by McCutcheon's, Detergents and Emulsifiers, North American Edition (1986), Allured Publishing Corporation; US Patent No. 5,011,681, issued April 30, 1991 to Ciotti et al .; U.S. Patent 4,421,769, issued December 20, 1983 to Dixon et al .; And US Patent No. 3,755,560, issued August 28, 1973 to Dickert et al., All of which are incorporated herein by reference in their entirety.

Suitable emulsifier types include esters of glycerin, esters of propylene glycol, fatty acid esters of polyethylene glycol, fatty acid esters of polypropylene glycol, esters of sorbitol, esters of sorbitan anhydride, carboxylic acid copolymers, esters and ethers of glucose, ethoxylation Ethers, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, soaps and mixtures thereof.

Suitable emulsifiers include polyethylene glycol 20 sorbitan monolaurate (polysorbate 20), polyethylene glycol 5 soya sterol, stearet-20, ceteareth-20, PPG-2 methyl glucose ether distearate, cetet-10, Polysorbate 80, cetyl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, polysorbate 60, glyceryl stearate, PEG-100 stearate, and mixtures thereof, but are not limited thereto.

Emulsifiers can be used individually or in mixtures of two or more, from about 0.1% to about 10% by weight of the composition, more preferably from about 1% to about 7% by weight, most preferably from about 1% to about It may be contained at a concentration in the range of 5% by weight.

Carboxylic Acid Copolymer Thickener

Another component useful in the compositions of the present invention is a carboxylic acid copolymer thickener. These crosslinked polymers contain acrylic acid, substituted acrylic acid, and one or more monomers derived from salts and esters of this acrylic acid and substituted acrylic acid, wherein the crosslinker has at least two carbon-carbon double bonds, polyhydric alcohols Derived from. Preferred polymers for use in the present invention are two general types. The first type of polymer is acrylic acid monomer or derivative thereof (e.g., acrylic acid is two and three independently C _1-4 alkyl, -CN, -COOH, and the substituent selected from the group consisting of a mixture thereof to carbon position Derivatives having a crosslinked homopolymer). Polymers of the second type are acrylic acid monomers or derivatives thereof (same as those described in the previous sentence), short chain alcohols (for example C _1-4 ) acrylate ester monomers or derivatives thereof (for example acrylic acid portions of esters) A derivative having a substituent selected from the group consisting of C _1-4 alkyl, -CN, -COOH, and mixtures thereof independently at the 2 or 3 carbon position, and a first monomer selected from the group consisting of mixtures thereof; And long chain alcohols (e.g. C _8-40) acrylate ester monomer or derivative thereof (e. G., Independently selected from C _1-4 alkyl, the acid portion of the ester is 2 or 3-carbon position, -CN, -COOH And derivatives having substituents selected from the group consisting of mixtures thereof). Combinations of these two types of polymers are also useful in the present invention.

In the first type of crosslinked homopolymer, the monomer is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid being most preferred. In the second type of crosslinked copolymer, the acrylic acid monomer or derivative thereof is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, and acrylic acid, methacrylic acid and mixtures thereof Most preferred. Short-chain alcohol acrylate ester monomers or derivatives thereof are preferably from the group consisting of C _1-4 alcohol acrylate esters, C _1-4 alcohol methacrylate esters, C _1-4 alcohol methacrylate esters, and mixtures thereof Most preferred are C _1-4 alcohol acrylate esters, C _1-4 alcohol methacrylate esters, and mixtures thereof. The long chain alcohol acrylate ester monomer is selected from C _8-40 alkyl acrylate esters, with C _10-30 alkyl acrylate esters being preferred.

Crosslinkers in both types of polymers are polyalkenyl polyethers of polyhydric alcohols containing one or more alkenyl ether groups per molecule, wherein the parent polyhydric alcohol contains three or more carbon atoms and three or more hydroxyl groups do. Preferred crosslinkers are those selected from the group consisting of allyl ethers of sucrose and allyl ethers of pentaerythritol, and mixtures thereof. These polymers useful in the present invention include US Pat. No. 5,087,445, issued February 11, 1992 to Haffey et al., Incorporated herein by reference in its entirety; U.S. Patent No. 4,509,949, issued April 5, 1985 to Huang et al .; US Patent No. 2,798 053, issued July 2, 1957 to Brown, is described in more detail. See also the CTFA International Cosmetic Ingredient Dictionary, 4th Edition, 1991, pages 12 and 80, incorporated herein by reference in its entirety.

Examples of the first type of commercial homopolymers useful in the present invention include carbomers which are homopolymers of acrylic acid crosslinked with pentaerythritol or sucrose allyl ethers. This carbomer is available as Carbopol® 900 series from BF Goodrich. Examples of the second type of commercially available copolymers useful in the present invention include copolymers of one or more acrylic acid, methacrylic acid monomers, or their short chain (e.g., C _1-4 alcohol) esters with C _10-30 alkyl acrylates. Wherein the crosslinker is allyl ether of pentaerythritol or sucrose. These copolymers are known as acrylate / C _10-30 alkyl acrylate crosspolymers and are commercially available as Carbopol® 1342, Pemulen TR-1, and Pemulen TR-2 from BF Goodrich. That is, examples of carboxylic acid polymer thickeners useful in the present invention are those selected from the group consisting of carbomers, acrylates / C ₁₀ -C ₃₀ alkyl acrylate crosspolymers, and mixtures thereof.

The composition of the present invention contains from about 0.025% to about 1%, more preferably from about 0.05% to about 0.75%, most preferably from about 0.10% to about 0.50% by weight of carboxylic acid polymer thickener. can do.

Other additional ingredients

The composition of the present invention may contain a wide variety of other additional ingredients. [CTFA Cosmetic Ingredient Handbook, 2nd Edition, 1992], which is hereby incorporated by reference in its entirety, includes a variety of non-limiting cosmetic and pharmaceutical applications commonly used in the hair and skin care industry, suitable for use in the compositions of the present invention. Product ingredients are described. Non-limiting examples of functional classes of ingredients are described on page 537 of this reference. Examples of these functional classes include absorbents, abrasives, anti-acne agents, anticaking agents, antifoam agents, antibacterial agents, antioxidants, binders, biological additives, buffering agents, extenders, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetic biocides. Agents, denaturants, drug astringents, film formers, perfume ingredients, opacifiers, pH adjusting agents, plasticizers, preservatives, propellants, reducing agents, additional skin-conditioning agents, suspending agents (nonsurfactants), ultraviolet absorbers, and viscosity increasing agents (Aqueous and non-aqueous). Other functional classes of materials useful in the present invention that are well known to those of ordinary skill in the art include solubilizers, sequestrants and the like.

In addition to the additional ingredients cited in the CTFA Cosmetic Ingredient Handbook, non-limiting examples of other materials useful in the present invention include the following: vitamins and derivatives thereof [eg, vitamin C, vitamin A (ie, retino) Acid), retinol, retinoids, and the like]; Antioxidants; Polyethylene glycol and polypropylene glycol; Polymers that aid the substantial and film forming properties of the compositions (eg, copolymers of eicosene and vinyl pyrrolidone, examples of which are available as Ganex® V-220 from GAF Chemical Corporation); Preservatives to maintain the antimicrobial nature of the composition; Antioxidants; Chelating agents and sequestering agents; Cross-linked and uncrosslinked nonionic and cationic polyacrylamides [eg, Salcare SC92 containing CTFA designated polyquaternium 32 (and) mineral oil, and CTFA designated polyquaternium 37 (and) mineral oil ( And) Salcare SC 95 containing PPG-1 trideset-6, and nonionic Seppi-Gel polyacrylamide available from Seppic Corp .; And aesthetic ingredients such as perfumes, pigments, colorings, essential oils, skin senates, astringents, skin calming agents, skin treatments and the like. Non-limiting examples of this aesthetic component include clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate, bisabolol, dipotassium glycysinate, and the like.

How to use

The compositions of the present invention are cosmetically suitable for products such as sun protection, anti-acne benefits, anti-wrinkle and skin anti-aging benefits, artificial tanning, analgesic benefits, skin conditioning benefits, facial moisturizing, lip protection, skin cleansing benefits, grooming aids, etc. Or in a conventional manner to provide pharmaceutical benefits. Such usage depends on the type of composition used, but generally involves topically applying an effective amount of the product to hair or skin. "Effective amount" means an amount sufficient to provide the desired benefit. Typical amounts of the compositions of the invention applied to hair or skin will vary depending on the type of composition and the desired benefit, but typical ranges are generally from about 1 g to about 25 g, with about 2 g being typical.

The following examples describe and describe embodiments within the scope of the invention in more detail. The examples are given for illustrative purposes only and are not intended to limit the invention, and various modifications thereof are possible without departing from the spirit of the invention.

Ingredients are indicated by chemical name or CTFA name.

Example 1

Topical compositions in the form of softening cleansers are prepared by combining the following ingredients using conventional mixing techniques. This composition utilizes a mixture of solid polyol fatty acid polyesters (solid sucrose polyesters) and liquid oils to provide softening and aesthetic benefits without leaving heavy feeling, stickiness or shine on the skin.

Phase A

Component weight percentage

Disodium EDTA 0.100

Glycerin 4.000

Methylparaben 0.200

Acrylate / C _10-30 Alkyl Acrylate Crosspolymer ¹ 0.150

Carbomer 954 ² 0.250

Water QS 100

Phase B

Stearic acid0.110

Stearyl Alcohol 0.875

Cetyl alcohol 0.875

Propylparaben 0.150

Stearette-2 0.250

Stearette-21 0.500

Solid Sucrose Polyester ³ 1.000

Phase C

Sodium hydroxide ⁴ 0.130

Phase D

Diisopropyl Sebacate 1.500

Isohexadecane 5.000

Phase E

Phenoxyethanol 0.500

Spices 0.150

Phase F

Glucose Amide 0.960

¹ , marketed as Pemulen® TR-1 by BF Goodrich Corporation.

² , marketed as Carbomer® 954 by BF Goodrich Corporation.

Solid sucrose octaester esterified with ³ 1 oleic acid and 7 behenic acid moiety.

⁴ 50% aqueous solution.

In a suitable vessel, the Phase A component is mixed at room temperature to form a dispersion, stirred and heated to 70-80 ° C. In a separate vessel, phase B ingredients are stirred and heated to 70-80 ° C. Phase B is then added to phase A while mixing to form an emulsion. Phase C is then added to neutralize the composition. Phase D ingredients are added with mixing and then cooled to 45-50 ° C. Phase E component is then added with stirring, then cooled to 40 ° C. Phase F is mixed and heated to 40 ° C. and added to the cooled emulsion to room temperature.

Example 2

Topical compositions in the form of shower products are prepared by combining the following ingredients using conventional mixing techniques. The composition utilizes a mixture of solid polyol fatty acid polyesters (solid sucrose polyesters) and liquid oils to provide softening and aesthetic benefits without leaving heavy feeling, stickiness or shine on the skin.

Component weight percentage

Sodium C _12/14 Alkyl Ether Glycerol Sulfonate 12.0

Ammonium Lauret-3 Sulfate 3.00

Myristic acid 1.00

Myristic Alcohol 1.00

Cocamidopropyl Betaine 3.00

Trihydroxystearin 1.75

Solid Sucrose Polyester ¹ 1.20

Tetrasodium EDTA 0.13

Glycerin 6.24

Perfume 0.80

Polyquat-10 (JR-30M) 0.30

Glidant 0.20

Malated Soybean Oil 1.00

Water QS 100

Solid sucrose octaester esterified with ¹ 1 oleic acid and 7 behenic acid moiety.

In a suitable vessel, polyquaart-10 is added to distilled water and mixed until fully hydrated. Surfactant and water soluble components are added and the mixture is heated to 70-80 ° C. with stirring. In a separate vessel, the solid sucrose polyester is combined with the liquid oil and trihydroxystearin, mixed and heated to homogenize and then added to the heated mixture at 70-80 ° C. The mixture is kept stirring and allowed to cool to 25-35 ° C. Glidant and perfume components are then added with stirring and the mixture is cooled to room temperature.

Example 3

Topical compositions in the form of shower products are prepared by combining the following ingredients using conventional mixing techniques. This composition utilizes a mixture of solid polyol fatty acid polyesters (solid sucrose polyesters) and liquid oils to provide softening and aesthetic benefits without leaving heavy feeling, stickiness or shine on the skin.

Component weight percentage

Ammonium Lauryl Sulfate 3.15

Ammonium Lauret-3 Sulfate 9.45

Na lauroamphoacetate 5.40

Polyquaternium-10 0.3

Trihydroxystearin 2.0

Solid Sucrose Polyester ¹ 1.20

Tetrasodium EDTA 0.13

Glycerin 3.0

Perfume 0.80

Citric Acid 0.76

Lauryl Alcohol 2.00

Mineral Oil 3.00

Water QS 100

Solid sucrose octaester esterified with ¹ 1 oleic acid and 7 behenic acid moiety.

In a suitable vessel, polyquaternium-10 is added to distilled water and mixed until fully hydrated. Surfactant and water soluble components are added and the mixture is stirred and heated to 70-80 ° C. In a separate vessel, the solid sucrose polyester is combined with liquid oil, lauryl alcohol and trihydroxystearin, mixed and heated to homogenize and then added to the heated mixture at 70-80 ° C. The mixture is kept stirring and the mixture is cooled to 25-35 ° C. Glidant and perfume components are then added with stirring and the mixture is cooled to room temperature.

Example 4

Topical compositions in the form of moisturizers are prepared by combining the following ingredients using conventional mixing techniques. This composition utilizes a mixture of solid polyol fatty acid polyesters (solid sucrose polyesters) and liquid oils to provide softening and aesthetic benefits without leaving heavy feeling, stickiness or shine on the skin.

Component weight percentage

Cetyl Alcohol 1.80

Stearic acid 0.25

Stearyl Alcohol 1.20

Peg 10-Stearate 0.25

Mineral Oil 2.00

Petrolatum 1.50

Isopropyl Palmitate 1.00

Cetyl Ricinoleate 1.00

Solid Sucrose Polyester ¹ 2.00

Dimethicone 350 ² 0.50

Propyl Paraben 0.10

Arlactone (RTM) 2121 ³ 1.00

Glycerin 9.00

Element 2.00

Octyl methoxycinnamate 2.00

Phenoxyethanol 0.25

Carbomer 1382⁴ 0.05

Carbomer 954⁵ 0.35

Tetrasodium EDTA 0.10

Titanium Dioxide 0.15

Methyl Paraben 0.20

NaOH 0.22

Dimethicone Q-21403⁶ 1.00

Isohexadecane 1.00

Water qslOO

Solid sucrose octaester esterified with ¹ 1 oleic acid and 7 behenic acid moiety.

² Dow Corning® 200 Fluid (350 centistokes) from Dow Corning.

³ 95% by weight of sorbitan stearate and 5% by weight of sucrose cocoate.

⁴ Carbopol® 13B.

⁵ Carbopol® 954 from BF Goodrich.

⁶ Dow Corning® Q-2 1403 from Dow Corning, a mixture of 85% by weight of dimethicone and 15% by weight of dimethiconal.

Primary premixes of solid sucrose polyester, arlactone 2121 and other water soluble components are prepared by mixing and heating in water. Secondary premixes of oily ingredients, except silicone, are prepared by mixing and heating and added to the aqueous premix. The resulting mixture is cooled. Silicone is then added to the resulting oil-in-water emulsion and the mixture is cooled before adding trace components.

Claims (10)

A composition comprising a blend of a solid polyol fatty acid polyester having a melting point of 30 ° C. to 80 ° C. and a liquid oil other than a liquid polyol fatty acid polyester having a melting point of 30 ° C. to less than −30 ° C., wherein the solid polyol fatty acid polyester is A composition containing a polyol moiety and at least one fatty acid moiety, the polyol moiety containing at least 4 free hydroxyl groups, wherein at least 60% of these free hydroxyl groups are esterified by at least one fatty acid moiety having from 8 to 22 carbon atoms . Topical compositions containing: (a) a combination of a solid polyol fatty acid polyester having a melting point of 30 ° C. to 80 ° C. and a liquid oil other than a liquid polyol fatty acid polyester having a melting point of 30 ° C. to less than −30 ° C., wherein the solid polyol fatty acid polyester is one polyol Part and at least one fatty acid moiety, the polyol moiety containing at least 4 free hydroxyl groups, wherein at least 60% of these free hydroxyl groups are esterified by at least one fatty acid moiety having from 8 to 22 carbon atoms Wt% to 99.9 wt% of the blend; And (b) about 0.1% to about 99.9% by weight topical carrier. The composition of claim 2 wherein the topical carrier is an oil-in-water emulsion. The composition of claim 2 wherein the topical carrier is anhydrous liquid solvent. 5. The moisturizer according to claim 2, wherein the hand lotion, body lotion, skin conditioning cream, skin protectant, sunscreen, cold cream, anti-acne composition, skin regeneration product, non-foam cleansing lotion, moisturizer, facial moisturizer , Compositions in the form of makeup products, foundations, lipsticks, lip protectors, hand cleansers, facial cleansers, body cleansers, shower products, shampoos and mixtures thereof. The composition of claim 1, wherein the polyol moiety is sucrose. 7. The fatty acid moiety according to any one of claims 1 to 6, wherein the fatty acid moiety is a long chain unsaturated fatty acid moiety having 12 to 22 carbon atoms, a short chain saturated fatty acid moiety having 2 to 12 carbon atoms, a long chain saturated fatty acid moiety having 20 to 22 carbon atoms, and mixtures thereof. A composition containing the. The liquid oil according to any one of claims 1 to 7, wherein the liquid oil is a mineral oil, a hydrocarbon having 5 to 16 carbon atoms, a fatty alcohol ester having 3 to 22 carbon atoms, a fatty acid ester having 3 to 30 carbon atoms, a vegetable oil and mixtures thereof. A composition selected from the group consisting of. A method for treating human hair or skin, comprising topically applying a safe effective amount of the composition of claim 1 to a human being in need thereof. A method for treating human hair or skin, comprising topically applying a safe effective amount of the composition of claim 2 to a human being in need thereof.