MXPA00004530A - Compositions containing combinations of liquid polyol fatty acid polyesters and a liquid oil - Google Patents

Abstract

Disclosed are compositions suitable for topical application to human hair or skin, which comprise (a) from about 0.1%to about 99.9%by weight of a liquid polyol fatty acid polyester having a melting point of from about -30°C to about 30°C, wherein the liquid polyol fatty acid polyester has a polyol moiety and at least 1 fatty acid moiety, the polyol moiety having at least 4 free hydroxyl groups wherein at least 60%of these free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms;and (b) from about 0.1%to about 99.9%by weight of a liquid oil having a melting point of from about -30°C to less than about 30°C, wherein the liquid oil is subtantially free of liquid polyol fattyacid polyesters, isohexadecane, isopropyl palmitate, or blends of C13-C14 isoparrafins and polyacrylamide and laureth-7. The composition preferably further comprises a topical carrier for the liquid polyol fatty acid polyester and liquid oil combination. The composition provides effective emolliency and aesthetic benefits.

Description

COMPOSITIONS CONTAINING COMBINATIONS OF LIQUID POLYOLIC POLYESTERS AND LIQUIDS AND OILS LIQUIDS FIELD OF THE INVENTION The present invention relates to compositions suitable for topical application in human hair or skin including a select combination of liquid polyol fatty acid polyesters with a melting point of between -30 ° C to 30 ° C, and a select liquid oil. with a melting point between -30 ° C and less than 30 ° C.

BACKGROUND OF THE INVENTION Topical emollient-containing compositions have been used for many years for the treatment of human hair or skin. For example, occlusive hydrocarbons, such as petrolatum or petrolatum, have been used as topical emollients to provide a protective layer on human skin that helps prevent the loss of water caused by interaction with the environment. Petrolatum has also been used in hair care products such as conditioners and other cleaning aids.

However, the most effective and widely used compositions containing occlusive emollients have adverse characteristics as regards their aesthetic qualities, since they are greasy and sticky. In addition, some of the occlusive emollients that are used to provide a protective layer on the skin clog pores thereof and impede the flow of oxygen. This obstruction of the surface of the skin or blockage of the passage or circulation of air and moisture limits the use of this type of heavy and occlusive emollient materials. Additionally the European patent no. 458,600 B1, issued March 2, 1994, describes occlusive skin care compositions containing a polyol fatty acid polyester with at least 4 free hydroxyl groups, at least 60% of which are esterified with one or more acids fatty acids that have between 8 and 22 carbon atoms that can form a film or occlusive layer on the skin after they are applied topically on it. The US patent no. 5,160,738, issued to Macaulay et al., On November 3, 1992, discloses other occlusive compositions containing a mixture of two or more polyol fatty acid polyesters with the appearance and physical characteristics of the petrolatum. However, these compositions have the disadvantage of being heavy, clogging the pores of the skin and preventing the flow of oxygen. Therefore, there is a need to find materials that are emollient and that also have acceptable aesthetic qualities, without being heavy or occlusive.

It has now been found that it is possible to formulate compositions containing non-occlusive emollients without being heavy, sticky or greasy. These compositions contain a select combination of liquid polyol fatty acid polyesters with a melting point of about -30 ° C to about 30 ° C, and a liquid oil with a melting point of between -30 ° C and less than 30 ° C, characterized in that the liquid oil is substantially free of liquid polyol fatty acid polyesters, isohexadecane, isopropyl palmitate or mixtures of Ci3-C isoparaffins? and polyacrylamide and laureth-7. These compositions can be incorporated into various products to provide both emollient and aesthetic benefits. It is therefore the object of this invention to provide a composition having acceptable and effective emollient and aesthetic qualities, and containing a non-occlusive emollient used in combination with a select liquid oil. It is also the object of this invention to provide topical compositions containing polyol fatty acid polyesters which are not heavy, sticky and greasy, and which are effective in the treatment of human hair or skin.

BRIEF DESCRIPTION OF THE INVENTION The present invention relates to a composition suitable for topical application on human hair or skin, which includes (a) between 0.1% and 99.9% by weight of a liquid polyol fatty acid polyester with a melting point of between -30 ° C and about 30 ° C, characterized in that the polyester of liquid polyol fatty acid has a polyol moiety and at least one fatty acid moiety, and the polyol moiety has at least 4 free hydroxyl groups characterized in that at least 60% of these free hydroxyl groups are esterified with one or more fatty acid moieties containing between 8 and 22 carbon atoms; and (b) between 0.1% and 99.9% by weight of a liquid oil with a melting point between -30 ° C and less than 30 ° C, characterized in that this liquid oil is substantially free of liquid polyol fatty acid polyesters, isohexadecane, isopropyl palmitate or mixtures of C13-C14 isoparaffins and polyacrylamide and laureth-7. Preferably, the composition further includes a topical vehicle for the combination of polyester of liquid polyol fatty acid and liquid oil. All percentages and ratios used herein are by weight and all measurements are made at 25 ° C, unless otherwise indicated. The invention of the present may include, consist of, or essentially include the fundamental ingredients, as well as the ingredients and optional components described herein.

DETAILED DESCRIPTION OF THE INVENTION The term "topical composition", as used herein, means a composition suitable for topical application on the hair or skin of a human being. The term is used to cover a whole series of cosmetic compositions, for personal care and beauty articles. Some of these topical compositions, but not limitingly, are lotions, creams, body lotions and hand lotions, skin conditioning lotions and creams, skin protection compositions, sunscreens, skin creams, compositions against acne, skin regenerating products, cleansing lotions that do not create foam, moisturizers, facial moisturizers, makeup, foundation for makeup, lipsticks, lip protectors, skin cleansers, hand cleaners, face and body, products for bathing, shampoos and the like. The term "topical carrier", as used herein, is well known to those skilled in the art and means one or more compatible solid or liquid fillers, diluents or carriers suitable for administration to humans. The term "compatible", as used herein, means that the components of the topical vehicle can be mixed with the components of the present invention, as well as with each other, such that there is no interaction that could significantly reduce the effectiveness or aesthetic qualities of the cosmetic composition under ordinary conditions of use. The topical vehicle must be a pharmaceutically acceptable vehicle. The term "pharmaceutically acceptable", as used herein, means that the topical carrier must be of sufficient purity and must be suitable for use upon contact with human hair or skin without toxicity, incompatibility, instability, allergic response and the like. The term "liquid", as used herein, refers to materials that are spillable fluids under ambient conditions of a pressure atmosphere, with about 50% relative humidity and about 20 ° C to about 25 °. C, unless otherwise specified. The term "selected liquid oils", as used herein, refers to liquid oil materials that have a melting point of less than about 30 ° C and that are substantially free of liquid polyol fatty acid polyesters, isohexadecane , isopropyl palmitate, or mixtures of C13-C14 isoparaffins and polyacrylamide and laureth-7.

In this context, the term "substantially free" means that the compositions preferably contain less than an effective amount of these materials when used in combination with the liquid polyol fatty acid polyester to provide emollient and aesthetic benefits.

Generally, the compositions contain less than 1%, preferably less than 0.5%, most preferably less than 0.25%, most preferably still less than 0.1%, and most preferably 0% by weight of these materials of the composition. The melting point of the liquid polyol fatty acid polyesters can be determined using conventional techniques. These techniques are well known to experts, and include thermometric and calorimetric methodologies. A particularly preferred technique for determining the melting point is that described in U.S. Pat. do not. 5,306,514, issued Letton et al., April 26, 1994, which is incorporated herein by reference. This technique commonly uses the measurement of melting points by Differential Scanning Calorimetry (DSC), characterized in that a scanning temperature of 5 ° C / min is used to measure the melting point. The melting point is the temperature at which the baseline linear crosses, this is the specific heat line, and the line tangent to the trailing edge of the endothermic peak.

Liquid polyol fatty acid polyester The composition of the present invention includes a non-occlusive liquid polyol fatty acid polyester at concentrations between 0.1% and 99.9%, preferably between 0.5% and 75%, most preferably between 1% and 50%, very preferably still between 2% and 25% by weight of the composition. These liquid polyol fatty acid polyesters have melting points below about 30 ° C, and are derived from any aliphatic or aromatic polyol having at least 4 free hydroxyl groups, of which at least 60% of these are then esterified with one or more fatty acids having between 8 and about 22 carbon atoms. Fatty acids can also be described as carboxylic acids, because the terms fatty acid and carboxylic acid are used interchangeably by those skilled in the art.

Among the liquid polyol polyesters used in this invention are certain polyols, especially sugars or sugar alcohols, esterified with one or more fatty acid groups. Accordingly, the polyol starting material must have at least 4 esterifiable hydroxyl groups. Among the preferred polyols are the sugars, including monosaccharides and disaccharides and sugar alcohols. Among the monosaccharides containing 4 hydroxyl groups are xylose and arabinose, and sugar alcohol derived from xylose, which has 5 hydroxyl groups, that is, xylitol. The monosaccharide erythrose is not suitable in the practice of this invention since it contains only three hydroxyl groups, but the sugar alcohol derived from erythrose, these is erythritol, contains 4 hydroxyl groups and can therefore be used. Among the monosaccharides containing five convenient hydroxyl groups are galactose, fructose and sorbose. Sugar alcohols containing six hydroxyl groups derived from the products of the hydrolysis of sucrose, as well as glucose and sorbose, for example sorbitol, are also convenient. Among the disaccharide polyols that can be used are maltose, lactose and sucrose, which contain eight hydroxyl groups. The polyols used in the liquid polyol esters of the present invention have between 4 and about 12, preferably between 4 and 11, and most preferably between 4 and 8 hydroxyl groups. The preferred polyols for preparing the polyesters that are used in the present invention are selected from a group consisting of erythritol, xylitol, sorbitol, glucose and sucrose. Sucrose is especially preferred. The preferred polyol starting material with at least four hydroxyl groups must be esterified in at least 60% of the hydroxyl groups with a fatty acid containing about 8 to 22 carbon atoms, preferably between 8 and 18 carbon atoms . Among these fatty acids are caprylic, capric, lauric, myristic, myristoleic, palmitic, palmitoleic, stearic, oleic, resinoléic, linoleic, linolenic, elephantic, ariquídic, arachidonic, behenic, and erucic acids. Fatty acids can be derived from natural or synthetic fatty acids. They can be saturated or unsaturated, including positional and geometric isomers. However, to obtain liquid polyesters of the type used herein, at least half of the fatty acid incorporated into the polyester molecule must be unsaturated. Especially preferred are oleic and linoleic acids, and mixtures thereof. The liquid polyol fatty acid polyesters useful in this invention should contain one or more fatty acid ester groups. It is not necessary that all hydroxyl groups of the polyol be esterified with fatty acids, but it is preferable that at least 60% of the hydroxyl groups be esterified with fatty acid ester groups. Most preferably, substantially all the hydroxyl groups of the polyol are esterified with fatty acids, that is, the polyol portion is substantially completely esterified. The fatty acids esterified in the polyol molecule can be itself or mixtures, but as indicated above, there must be a substantial amount of the unsaturated acid ester groups to obtain liquid characteristics. To illustrate the above, sucrose fatty acid ester would be convenient for use herein, but it is not preferred since it has more than two non-esterified hydroxyl groups. Likewise, the tetraacid ester of sucrose would be convenient, but it is not preferred since it has more than two unesterified hydroxyl groups. Among the highly preferred compounds in which all hydroxyl groups are esterified with fatty acids are the suctasubstated fatty acid esters of liquid sucrose. Among the specific liquid polyol fatty acid polyesters containing one or more fatty acid ester groups suitable for use in the present invention are, but are not limited to: glucose oleate, glucose ester, fatty acid, fatty acid soybean (unsaturated), mixed soybean oil fatty acid maleate ester, oleic acid galactose ester, linoleic acid arabinose ester, xylose linoleate, sorbitol oleate, sucrose oleate, glucose dioleate, glucose diester of soybean oil fatty acids (unsaturated), mixed soybean oil fatty acid diesters, oleic acid galactose diesters, linoleic acid arabinose diesters, xylose dilinoleate, sorbitol dioleate, sucrose dioleate, trioleate glucose, glucose triesters of soybean oil fatty acids (unsaturated), mixed soybean oil fatty acid trésteres , triesters of galactose of oleic acid, triesters of arabinose of linoleic acid, trilinoleate of xylose, trioleate of sorbitol, trioleate of sucrose, tetraesters of glucose of fatty acids of soybean oil (unsaturated) tetraesters of mañosa of fatty acids of soybean oil mixtures, tetraesters of galactose of oleic acid, tetraesters of arabinose of linoleic acid, tetralinoleate of xylose, tetraoleate of sorbitol, pentaoleate of galactose, hexaesters of sorbitol of fatty acids of unsaturated soybean oil, xylitol pentaoleate, sucrose tretaoleate, pentaoleate sucrose, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof. Liquid polyol esters selected from a group consisting of sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof are preferred. Most preferably sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof. The preferred liquid polyol fatty acid polyesters of the present invention have melting points of between -30 ° C and about 30 ° C, preferably -30 ° C and 27.5 ° C, and most preferably between -30 ° C and 25 ° C. ° C. The melting points are measured using conventional techniques. The polyol fatty acid polyesters suitable for use herein can be made by various methods well known in the art. Among these methods is: the transesterification of polio! with fatty acid esters of methyl, ethyl or glycerol using a variety of catalysts; the acylation of the polyol with a fatty acid chloride; the acylation of the polyol with a fatty acid anhydride; and the acylation of the polyol with a fatty acid, by itself. See the patent of E.U.A. No. 2,831, 854 and the patent of E.U.A. No. 4,005,196, issued to Jandacek on January 25, 1977, incorporated herein by reference.

Liquid Oil The composition of the present invention includes a select liquid oil, as defined herein, which is used in combination with the liquid polyol fatty acid polyester described herein. The concentrations of the selected liquid oil are between 0.1% and 99.9%, preferably between 0.5% and 75%, most preferably between 1% and 50%, most preferably between 2% and 25% by weight of the composition. Liquid oils useful herein are those materials substantially free of liquid polyol fatty acid polyesters, isohexadecane, isopropyl palmitate, or mixtures of C13-C14 isoparaffins and polyacrylamide and laureth-7, and having a melting point of less of 30 ° C, preferably between -30 ° C and less than about 30 ° C, most preferably between -30 ° C and 27.5 ° C, and most preferably still between -30 ° C and 25 ° C. Suitable liquid oils include, but are not limited to, mineral oil, hydrocarbons having between 5 and 16 carbon atoms, esters of fatty alcohol with between 3 and 22 carbon atoms, fatty acid esters having between 3 and 30 carbon atoms, vegetable oils and mixtures thereof. Other liquid oils suitable for use herein are described in Patent No. WO 95-00166, issued to Gordon et al, on January 5, 1995, which is incorporated herein by reference. Mineral oil, also known as liquid petrolatum, is suitable for use in the present. It is a mixture of liquid hydrocarbons obtained from petroleum. See The Merck Index, tenth edition, annotation 7048, p. 1033 (1983), and International Cosmetic Ingredient Dictionary, fifth edition, vol. 1, pp. 415-417 (1993), which are incorporated herein by reference. Among the selected hydrocarbon liquid oils suitable for use herein are straight and branched chain hydrocarbons with between 5 and 16 carbon atoms. Among these hydrocarbon materials are, but not limited to, dodecane, sododecane, hydrogenated polyisobutylene and hexadecane. C5-C16 isoparaffins are also useful, excluding C3-C1 isoparaffins when these compounds are used in combination with polyacrylamide and laureth-7. C5-C6 isoparaffins are also known as C5-C16 branched hydrocarbons. Among the fatty alcohol esters suitable for use as a select liquid oil as defined herein are esters and diesters of fatty alcohols having between 3 and 22 carbon atoms. Also useful are fatty acid esters having between 3 and 28 carbon atoms. Among these ester materials are, but are not limited to, isopropyl myristate, isopropyl stearate, diisopropyl adipate and dioctyl sebacate (dioctyl ester of decanodioic acid). Other suitable liquid oils suitable for use herein are liquid vegetable oils at an ambient temperature between 20 ° C and 25 ° C. Among these convenient vegetable oils are cod liver oil, dolphin oil, lard oil, cow paw oil, porpoise oil, seal oil, sperm whale oil, whale oil, acorn oil, almond oil. , beech nut oil, chaulmugra oil, rape seed oil, soybean oil, sunflower seed oil, peanut oil, cottonseed oil, corn oil, safflower oil, olive oil, oil of sábalo, sesame seed oil, castor oil, hazelnut oil, hemp seed oil, flaxseed oil, black mustard seed oil, Mella Azadirachta oil, peanut oil, pistachio oil, seed oil of poppy, pumpkin seed oil, oil of Aleurítes Fordii, white mustard seed oil, pine oil, wheat germ oil and derivatives and mixtures thereof.

Topical vehicle The composition of the present invention includes between 0.1% and 99.9%, preferably between 50% and 99%, and most preferably between 60% and 95% by weight of a topical carrier for the combination of liquid polyol fatty acid polyester and of liquid oil, as well as for any other optional component of the present invention. The combination of liquid polyol fatty acid polyester and liquid oil of the present invention can be formulated in the form of a wide range of product types, including creams, lotions, milk, gel, hand and body lotions, skin creams , cleansing lotions that do not create foam, facial moisturizers, sunscreens, acne preparations, topical analgesics, mascara, lipstick, skin cleansers, hand cleansers, face and body, bath products, shampoos and the like. The vehicles and additional components required to formulate these products vary according to the type of product, and the person skilled in the art will be able to determine which components he will use. The topical vehicle can come in different forms. For example, as emulsion vehicles, including but not limited to emulsions of oil in water, water in oil, water in oil-oil in water, and oil in water-silicone. These emulsions can cover a wide range of viscosities, for example, between 100 cps and about 200,000 cps. Other suitable topical vehicles are anhydrous liquid solvents such as alcohols and silicones (e.g., ethanol, sodium propane, dimethicone, cyclomethicone and the like; aqueous single-phase liquid solvents (eg, hydroalcoholic solvent systems; and thickened versions) of these anhydrous and single-phase water-based solvents (for example, when the viscosity of the solvent has been increased to form a solid or semi-solid by the addition of the relevant gums, resins, waxes, polymers, salts and the like). of the topical carrier systems useful in the present invention are described in the following references, all incorporated herein by reference in their entirety: "Sun Products Formulary" Cosmetics &Toiletries, vol 105, pp. 122-139 (December 1990) "Sun Products Formulary", Cosmetics &Toiletries, vol 102, pp. 117-136 (March 1987), US Patent No. 4,960,764 issued Figueroa et al., October 2, 1990; patent of E.U.A. No. 4,254,105 issued to Fukuda et al., March 3, 1981; patent of E.U.A. No. 4,976,953 issued to Orr et al., December 11, 1990; patent of E.U.A. No. 5,073,372; issued to Tumer et al., December 17, 1991; patent of E.U.A. No. 5,585,104, issued to Ha et al., December 17, 1996; patent of E.U.A. No. 5,607,678 issued to Moore et al., March 4, 1997; the patent of E.U.A. No. 5,607,980, issued to McAtee et al., March 4, 1997; and the patent of E.U.A. No. 5,618,522, issued to Kaleta et al., April 8, 1997. The topical vehicle may also include an oil-in-water emulsion system with complex structures such as liquid crystals and crystalline gel networks. The nature of the liquid crystals, as well as the formation, characteristics and advantages thereof are described in greater detail in the following documents: G. Dahms, Properties of O / W Emulsions With Anisotropic Lameliar Phases, 101 Cosmetics & Toiletries, 113-115 (1986); P. Loll, Liquid Crystals, Cosmetic Emulsions, ICI Suriactants' Publication RP94-93E; and G.M. Eccleston, Multiple-Phase Oil-ln-Water Emulsions, 41, J. Soc. Cosmet. Chem., 1-22, (January / February 1990); all these documents are incorporated herein by reference.

Additional components It is possible to incorporate a large variety of additional components to the compositions herein. Of enunciative but not limitative way, between these components we have: Pharmaceutical Active Compounds The compositions of the present invention may include a safe and effective amount of a pharmaceutical active compound. The phrase "safe and effective amount", as used herein, means an amount of an asset high enough to significantly or positively modify the condition to be treated, but low enough to avoid any serious side effects (at a reasonable benefit / risk ratio) , within the scope of a diagnosis or successful medical reasoning. The safe and effective amount of the pharmaceutical active will vary according to the specific active compound, the ability of the composition to penetrate the active through the skin, the amount of composition applied, the condition being treated in particular, the age and physical condition of the patient under treatment, the severity of the condition, the duration of the treatment, the nature of the concurrent therapies and similar factors. The pharmaceutical active compounds that can be used in the compositions of the present invention preferably constitute between 0.1% and 20% by weight of the compositions, most preferably between 0.1% and 10%, and most preferably still between 0.1% and 5%. . It is also possible to use mixtures of different pharmaceutical actives. Among the active pharmaceutical compounds that can be used are, but are not limited to: One of the active pharmaceutical compounds in the compositions of the present invention are the anti-acne drugs. These drugs include keratolytics such as salicylic acid, sulfur, lactic acid, glycolic acid, pyruvic acid, resorcinol and N-acetylcysteine.; retinoids such as retinoic acid and its derivatives (eg, cis and trans); antibiotics and antimicrobials such as benzoyl peroxide, octopirox, erythromycin, zinc, tetracycline, triclosan, azelaic acid and its derivatives, phenoxyethanol and phenoxypropanol, ethyl acetate, clindamycin and meclocycline; sebaptics such as flavonoids; alpha and beta hydroxy acids; and bile salts such as escimnol sulfate and its derivatives, deoxycholate and cholate. The preferred anti-acne actives are selected from the group consisting of salicylic acid, sulfur, resorcinol, lactic acid, zinc, erythromycin, benzoyl peroxide, and mixtures thereof. The most preferred is salicylic acid.

Among the active pharmaceutical compounds useful in the compositions of the present invention are non-steroidal anti-inflammatory drugs (NSAIDS). NSAIDs can be selected from the following categories: propionic acid derivatives; acetic acid derivatives; phenamic acid derivatives; diphenylcarboxylic acid derivatives; and oxicams. All of these NSAIDS are described in U.S. Pat. No. 4,985,459 issued to Sunshine at al., January 15, 1991, incorporated herein by reference. Most preferred are propionic NSAIDS including, but not limited to, aspirin, acetaminophen, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, microprofen, thioxaprofen , alminoprofen, thiaprofenic acid, fluprofen and bucloxic acid. Steroidal anti-inflammatory drugs including hydrocortisone and the like are also useful. Pharmaceutical active compounds useful in the compositions of the present invention include antipruritic drugs. Preferred antipruritic drugs to be included herein include pharmaceutically acceptable salts of metdilizine and trimeprazine. The pharmaceutical active compounds useful in the compositions of the present invention include anesthetic medicaments. Preferred anesthetic medicaments for inclusion herein include pharmaceutically acceptable salts of lidocaine, bupivacaine, chlorprocaine, digobucaine, etidocaine, mepivacaine, tetracaine, dyclonine, hexylcaine, procaine, cocaine, ketamine, pramoxin and phenol. The active pharmaceutical compounds useful in the compositions of the present invention include antimicrobial drugs (antibacterial, antifungal, antiprotozoal and antiviral drugs). Preferred antimicrobial drugs to be included herein include pharmaceutically acceptable salts of β-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, triclosan, doxycycline, capreomycin, chlorhexidine, chlortetracycline, oxytetracycline, clindamycin, ethambutol, metronidazole, pentamidine, gentamicin, kanamycin, lineomycin, metacycline, methenamine, minocycline, neomycin, netilmicin, paromomycin, streptomycin, tobramycin, miconazole and amanfadine. Preferred antimicrobial drugs to be included herein include tetracycline hydrochloride, erythromycin estolate, erythromycin stearate (salt), amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, hydrochloride of oxytetracycline, clindamycin hydrochloride, ethambutol hydrochloride, metronidazole hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, lineomycin hydrochloride, methacycline hydrochloride, methenamine hippurate, methenamine mandelate, minocycline hydrochloride, neomycin sulfate , netilmicin sulfate, paromomycin sulfate, streptomycin sulfate, tobramycin sulfate, miconazole hydrochloride, amanfadine hydrochloride, amanfadine sulfate, triclosan, octopirox, parachloromethaxyleneol, nystatin, tolnaftate and clotrimazole. Sunscreen agents are also useful herein. A wide variety of sunscreen agents are described in the patent E.U.A. No. 5,087,445 to Haffey et al., Issued February 1, 1992; patent of E.U.A. No. 5,073,372, Turner et al, issued December 17, 1991; patent of E.U.A. No. 5,073,371, Turner et al. issued on December 17, 1991; and Segarin, et al., in chapter VIII pages 189 et se. of Cosmetics Science and Technology, all of which is incorporated herein by reference in its entirety. Preferred among said sunscreens which are useful in the compositions of the present invention are those selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, homomenthyl salicylate, octyl salicylate, 4,4'-methoxy-t = butyldibenzoylmethane , 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. Other useful sunscreens are those described in the U.S. patent. No. 4,937,370 of Sabatelli, issued June 26, 1990; and the patent E.U.A. No. 4,999,186 of Sabatelli et al., Issued March 12, 1991; These two references are incorporated by reference herein in their entirety. The sunscreen agents described therein have, in a single molecule, two distinct chromophore portions which have different absorption spectra of ultraviolet radiation. One of the chromophore portions absorbs predominantly in the UVB radiation range and the other absorbs strongly in the UVA radiation range. These sunscreen agents provide greater efficiency, wider UV light absorption, lower skin penetration and longer lasting efficacy compared to conventional sunscreens. Especially preferred examples of these sunscreens include those selected from the group consisting of 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N- (2-ethylhexyl) ester ) methylaminobenzoic acid with 4-hydroxydibenzoylmethane, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4-N, N- (2-ethylhexyl) ester 4- (2-hydroxyethoxy) dibenzoylmethane methylaminobenzoic acid, and mixtures thereof. In general, the compositions may comprise from about 0.5% to about 20% of the sunscreens useful herein. The exact amounts will vary depending on the chosen sunscreen and the desired Sun Protection Factor (SPF). SPF is a commonly used photoprotection measure of a sunscreen against erythema. See Federal Register. Vol. 43, No. 166, pp. 38206-38269, August 25, 1978, which is hereby incorporated by reference in its entirety. Also useful in the compositions of the present invention are sunless tanning agents including dihydroxyacetone, glyceraldehyde, indoles and their derivatives, and the like. These sunless tanning agents can also be used in combination with sunscreen agents. Other useful active compounds include skin whitening (or brightening) agents including, but not limited to, hydroquinone, ascorbic acid, kogic acid, and sodium metabisulfite.

Moisturizers and humectants The compositions of the present invention may also contain one or more additional moisturizing or humectant materials other than those described herein. A variety of these materials may be employed and each may be present at a level of from about 0.1% to about 20%, preferably from about 1% to about 10% and most preferably from about 2% to about 5%, by weight of the composition. These materials include guanidine; glycolic acid and glycolate salts (eg, ammonium and alkylammonium-quaternary); lactic acid and lactate salts (for example, ammonium and alkylammonium-quaternary); zabila in any of its variety of forms (for example, zabila gel); polyhydric alcohols such as sorbitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; sugars and starches; sugar and starch derivatives (eg, alkoxylated glucose); hyaluronic acid; lactate monoethanolamine; acetamide monoethanolamine; and mixtures thereof.

Emulsifiers The compositions herein may contain various emulsifiers. These emulsifiers are useful for emulsifying the various carrier components of the compositions herein. Suitable emulsifiers can include any of a wide variety of nonionic, cationic, anionic, and zwitterionic emulsifiers which are described in the above patents and other references. See McCutcheon Detergents and Emulsifiers, US edition (1986), published by Allured Publishing Corporation; patent of E.U.A. No. 5,01 1, 681 of Ciotti et al., Issued April 30, 1991; patent of E.U.A. No. 4,421, 769 of Dixon et al, issued December 20, 1983; and patent of E.U.A. No. 3,755,560 of Dickert et al, issued August 28, 1973; These four references are incorporated herein by reference in their entirety. Suitable types of emulsifiers include glycerin esters, propylene glycol esters, polyethylene glycol fatty acid esters, polypropylene glycol grade acid esters, sorbitol esters, sorbitan anhydride esters, carboxylic acid copolymers, esters and glucose ethers, esters ethoxylates, ethoxylated alcohols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactylates, soaps and mixtures thereof. Suitable emulsifiers may include, but are not limited to, polyethylene glycol sorbitan monolaurate 20 (Polysorbate 20), polyethylene glycol 5 soybean stearate, Steareth-20, Ceteareth-20, methylgluous ether distearate of PPG-2, Ceteth- 10, Polysorbate 80, cetylphosphate, potassium cetylphosphate, diethanolamine cetylphosphate, Polysorbate 60, glyceryl stearate, PEG-100 stearate and mixtures thereof. The emulsifiers can be used individually or as a mixture of two or more and can be included in concentrations ranging from about 0.1% to about 10%, preferably from about 1% to about 7%, and most preferably from about 1% to about 5%, by weight of the composition.

Carboxylic acid copolymer thickeners Another useful component in the compositions herein is a carboxylic acid copolymer thickener. These crosslinked polymers contain one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol. Preferred polymers for use herein are of two general types. The first type of polymer is an entangled homopolymer of an acrylic acid monomer or derivative thereof (eg, wherein the acrylic acid has substituents at the two carbon and three carbon positions independently selected from the group consisting of C1-alkyl 4, -CN, -COOH, and mixtures thereof). The second type of polymer is an entangled copolymer having a first monomer selected from the group consisting of an acrylic acid monomer or derivative thereof (as just described), a short chain alcohol acrylate ester monomer (s) say a C1-4) or derivative thereof (eg, wherein the acrylic acid portion of the ester has substituents at the two and three carbon positions independently selected from the group consisting of C1-4 alkyl, -CN, - COOH, and mixtures thereof), and mixtures thereof; and a second monomer which is a long-chain alcohol acrylate ester monomer (ie C8-0) or derivative thereof (eg, where the acrylic acid portion of the ester has substituents at the two and three carbon positions). independently selected from the group consisting of C -? - 4 alkyl, -CN, -COOH, and mixtures thereof). The combinations of these two types of polymers are also useful herein. In the first type of crosslinked homopolymers the monomers are preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid being preferred. In the second type of crosslinked copolymers the acrylic acid monomer or derivative thereof is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid, methacrylic acid and mixtures of they are the preferred ones. The short chain alcohol acrylate ester monomer or derivative thereof is preferably selected from the group consisting of C1-4 alcohol acrylate esters, Cr4 alcohol alcohol methacrylate esters, alcohol ethacrylate esters of C1-4, and mixtures thereof, with the C1-4 alcohol acrylate esters, C1-4 alcohol methacrylate esters, and mixtures thereof, being preferred. The long chain alcohol acrylate ester monomer is selected from Cs-40 alkyl acrylate esters, with C10-30 alkyl acrylate esters being preferred. The crosslinking agent in both of these types of polymers is a polyether polyalkenyl of a polyhydric alcohol containing more than one alkenyl ether group per molecule, wherein the parent polyhydric alcohol contains at least 3 carbon atoms and at least 3 hydroxyl groups. Preferred crosslinkers are those selected from the group consisting of allyl esters of sucrose and allyl esters of pentaerythritol, and mixtures thereof. These polymers useful in the present invention are described in detail in the U.S.A. No. 5,087,445 to Haffey et al, issued February 1, 1992; U.S. Patent No. 4,509,949 to Huang et al, issued April 5, 1985; patent of E.U.A. No. 2,798,053 of Brown, issued July 2, 1957; which they incorporate here by reference. See also, CTFA International Cosmetic Ingredient Dictionarv (CTFA International Cosmetic Ingredient Dictionary), fourth edition 1991, pp. 12 and 80; which is also incorporated herein by reference. Examples of homopolymers of the first type useful herein commercially include carbomers, which are homopolymers of acrylic acid crosslinked with allylic esters of sucrose or pentaerythritol. The carbomers are available as the Carbopol® 900 series from B.F. Goodrich. Examples of copolymers of the second type useful herein commercially include copolymers of C?-3o alkyl acrylates with one or more monomers of acrylic acid, methacrylic acid, or one of their short chain esters (i.e. C1-4), wherein the interlacing agent is an allyl ester of sucrose or pentaerythritol. These copolymers are known as interlaced acrylates / polymers of C10-30 alkyl acrylate and are commercially available as Carbopol® 1342, Pemulen TR-1, and Pemulen TR-2, from B.F. Goodrich. In other words, examples of carboxylic acid polymer thickeners useful herein are those selected from the group consisting of C.sub.10-30 alkyl acrylate crosslinked carbomers, acrylates / polymers, and mixtures thereof. The compositions of the present invention may comprise from about 0.025% to about 1%, preferably from about 0.05% to about 0.75%, and most preferably from about 0.10% to about 0.50%, by weight of the carboxylic acid polymer thickeners.

Other additional components The compositions of the present invention may comprise a wide range of other additional components. The CTFA Cosmetic Ingredient Handbook, second edition, 1992, which is hereby incorporated by reference in its entirety, describes a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the care industries of the body. hair and skin, which are suitable for use in the compositions of the present invention. Examples that are not limited to functional classes of ingredients are described on page 537 of this reference. Examples of these functional classes include: absorbers, abrasives, anti-acne agents, cake antiforming agents, foam anti-foaming agents, antimicrobial agents, antioxidants, binders, biological additives, pH-regulating agents, body-forming agents, chelating agents, additives chemicals, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, film formers, fragrance component, opacifying agents, pH adjusters, plasticizers, preservatives, propellants, reducing agents, additional skin conditioning agents, suspending agents (no surfactant), ultraviolet light absorbers, and viscosity increasing agents (aqueous and non-aqueous). Examples of other functional classes of materials useful herein that are well known to those skilled in the art include solubilizing agents, sequestering agents, and the like. Non-limiting examples of these additional components mentioned in the CTFA Cosmetic Ingredient Handbook, as well as other materials useful herein, include the following: vitamins and derivatives thereof [eg, vitamin C , Vitamin A (ie, retinoic acid), retinol, retinoids, and the like]; antioxidants; polyethylene glycols; polymers for assisting the film-forming properties and substantivity of the composition (such as a copolymer of eicosene and vinylpyrrolidone, an example of which is available from GAF Chemical Corporation as Ganex® V-220); preservatives to maintain the antimicrobial integrity of the compositions; antioxidants; chelators and sequestrants; interlaced and non-interlaced cationic polyacrylamides [eg, Saleare SC92 which has the designation CTFA polyquaternium 32 (and) mineral oil, and Saleare SC95 which has the designation CTFA polyquaternium 37 (and) mineral oil (y) PPG-1 trideceth -6]; and aesthetic components such as fragrances, pigments, dyes, essential oils, skin sensitizers, astringents, skin softening agents, skin healing agents and the like, non-limiting examples of these aesthetic components include clove oil, menthol , camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate, bisabolol, dipotassium glycyrrhizinate, and the like.

Methods of use The compositions of the present invention are used in conventional ways to provide cosmetic or pharmaceutical benefits appropriate to the product such as sun protection, anti-acne benefits, anti-wrinkle and anti-aging benefits of the skin, artificial tanning, analgesic benefits, conditioning benefits. of the skin, facial moisturization, protection for the lips, skin cleansing benefits, auxiliary for personal grooming, and the like. Said methods of use depend on the type of composition employed but generally involve topical application of an effective amount of the product to the hair or skin. By "effective amount" is meant an amount sufficient to provide the desired benefit. The typical amounts of the compositions of the present invention that are applied to the hair or skin will vary depending on the type of composition and the desired benefit, however, typical ranges are generally from about 1 gram to about 25 grams, with approximately 2 grams being typical .

EXAMPLES The following examples describe and show better embodiments within the scope of the present invention. The examples are provided solely for the purpose of illustrating and should not be construed as limitations of the present invention, since many variations thereof are possible without departing from the spirit and scope of the invention. The ingredients are identified by the chemical or CTFA name.

EXAMPLE 1 A topical composition in the form of a bath product is prepared by combining the following ingredients using conventional mixing techniques. This composition utilizes a non-occlusive liquid polyol fatty acid polyester (liquid sucrose polyester) and a liquid oil to provide emolliency and aesthetic benefits without leaving the skin feeling harsh, sticky or oily.

Ingredients Percent by weight Alkyl ether glycerol sulfonate of C12 / 14 of 12.0 sodium Laureth-3 ammonium sulfate 3.00 Myristic acid 1.00 Myristic alcohol 1.00 Cocamidopropylbetaine 3.00 Polyester of liquid sucrose1 15.3 EDTA of tetrasodium 0.13 Glycerin 6.24 Perfume 0.80 Polyquat -10 (JR-30M) 0.30 Slip agent 0.20 Maleated soybean oil 1.00 Water CS 100 1 The liquid sucrose polyester is a mixture of esters of hexa-, hepta-, and octa-sucrose, predominantly the octa-ester esterified with mixed soybean oil fatty acids. In an appropriate container, Polyquat-10 is added to distilled water and allowed to mix until completely hydrated. The surfactants, and water soluble ingredients, are added and the mixture is heated by stirring at 70-80 ° C. In a separate container, the liquid sucrose polyester is combined with the liquid oil, heated by mixing until uniform, and then added to the heated mixture at 70-80 ° C. The mixture is allowed to cool to 25-35 ° C while continuing to stir. Then the ingredients of slippery agent and perfume are added with stirring, and the mixture is cooled to room temperature.

EXAMPLE 2 A topical composition in the form of a bath product is prepared by combining the following ingredients using conventional mixing techniques. This composition utilizes a blend of a non-occlusive liquid polyol fatty acid polyester (liquid sucrose polyester) and a liquid oil to provide emolliency and aesthetic benefits without leaving the skin feeling rough, sticky or oily.

Ingredients Percent by weight Ammonium lauryl sulfate 3.15 Laureth-3 ammonium sulfate 9.45 Lauroanfoacetate Na 5.40 Polyquatemium-10 0.30 Liquid sucrose polyester1 15.3 Mineral oil 3.00 Tetrasodium EDTA 0.13 Glycerin 3.00 Perfume 0.80 Citric acid 0.76 Lauryl alcohol 2.00 Water CS 100 1 The Liquid sucrose polyester is a mixture of esters of hexa-, hepta-, and octa-sucrose, predominantly the octa-ester esterified with mixed soybean oil fatty acids. In an appropriate container, Polyquatemium-10 is added to distilled water and allowed to mix until completely hydrated. The surfactants, and water soluble ingredients, are added and the mixture is heated by stirring at 70-80 ° C. In a separate container, the liquid sucrose polyester is combined with the liquid oil and lauryl alcohol, heated by mixing until uniform, and then added to the heated mixture at 70-80 ° C. The mixture is allowed to cool to 25-35 ° C while continuing to stir. The ingredients of slippery agent and perfume are then added by stirring, and the mixture is cooled to room temperature.

EXAMPLE 3 A topical composition in the form of a humectant is prepared by combining the following ingredients using conventional mixing techniques. This composition uses a mixture of a non-occlusive liquid polyol fatty acid polyester (liquid sucrose polyester) and a liquid oil to provide emolliency and aesthetic benefits without leaving the skin feeling rough, sticky or oily.

Ingredients Percentage by weight Cetyl alcohol 1.80 Stearic acid 0.25 Stearyl alcohol 1.20 Peg 100 stearate 0.25 Mineral oil 2.00 Liquid sucrose po1ester 4.00 Dimemetic 3502 0.50 Propylparaben 0.10 Arlatone (RMT) 21213 1.00 Glycerin 9.00 Urea 2.00 Octylmethoxycinnamate 2.00 Phenoxyethanol 0.25 Carbomer 13824 0.05 Carbomer 9545 0.35 Tetrasodium EDTA 0.10 Titanium dioxide 0.15 Methylparaben 0.20 NaOH 0.22 Dimethicone Q-214036 1.00 Water cs100 1 The liquid sucrose polyester is a mixture of esters of hexa-, hepta-, and octa-sucrose, predominantly the octa-ester esterified with mixed soybean oil fatty acids. 2 Fluid from Dow Corning® 200 (350 centistokes) from Dow Corning. 3 95% by weight of sorbitan stearate and 5% by weight of sucrose cocoate. 4 Carbopol® 1382 from B.F. Goodrich. 5 Carbopol® 954 from B.F. Goodrich. 6 Q-2 1403 Dow Corning® from Dow Corning which is a blend of 85% by weight dimethicone and 15% by weight dimethiconal.

A first premix of liquid sucrose polyester, Arlatone 2121 and other water soluble ingredients is prepared by mixing in water and heating. A second premix of oil phase ingredients other than silicones is prepared by mixing and heating and added to the aqueous premix. The resulting mixture is cooled. The silicones are then added to the resulting oil-in-water emulsion and the mixture is cooled before adding the minor ingredients.

Claims (19)

NOVELTY OF THE INVENTION CLAIMS

1. - A composition comprising: (a) of about

0. 1% to about 99.9% by weight of a liquid polyol fatty acid polyester having a melting point of about -30 ° C to about 30 ° C, further characterized in that the polyester of liquid polyol fatty acid has a polyol portion and at least 1 fatty acid portion, the polyol portion having at least 4 free hydroxyl groups wherein at least 60% of these free hydroxyl groups are esterified with one or more fatty acid moieties having from about 8 to about 22 carbon atoms; and (b) from about 0.1% to about 99.9% by weight of a liquid oil having a melting point of about -30 ° C to less than about 30 ° C, further characterized in that the liquid oil is substantially free of polyesters of fatty acid liquid polyols, isohexadecane, isopropyl palmitate, mixtures of C13-C14 isoparaffins and polyacrylamide and laureth-7, or combinations thereof. 2. The composition according to claim 1, further characterized in that the fatty acid portion contains from about 8 to about 18 carbon atoms.

3. - The composition according to claim 1, further characterized in that the polyol portion is selected from the group consisting of erythritol, xylitol, sorbitol, glucose, sucrose, and mixtures of the mims.

4. The composition according to claim 3, further characterized in that the polyol portion is sucrose.

5. The composition according to claim 4, further characterized in that the liquid polyol fatty acid polyester has a melting point of about -30 ° C to about 25 ° C.

6. The composition according to claim 1, further characterized in that the liquid oil has a melting point of about -30 ° C to about 25 ° C.

7. The composition according to claim 6, further characterized in that the liquid oil is selected from the group consisting of mineral oil, hydrocarbons having from about 5 to about 16 carbon atoms, fatty alcohol esters having from about 3. to about 22 carbon atoms, fatty acid esters having from about 3 to about 30 carbon atoms, vegetable oils, and mixtures thereof.

8. A topical composition comprising: (a) from about 0.1% to about 99.9% by weight of a liquid polyol fatty acid polyester having a melting point of about -30 ° C to about 30 ° C, further characterized because the. polyester of liquid polyol fatty acid has a polyol portion and at least 1 fatty acid portion, the polyol portion having at least 4 free hydroxyl groups wherein at least 60% of these free hydroxyl groups are esterified with one or more acid portions fatty acids having from about 8 to about 22 carbon atoms; (b) from about 0.1% to about 99.9% by weight of a liquid oil having a melting point of about -30 ° C to less than about 30 ° C, further characterized in that the liquid oil is substantially free of acid polyesters liquid polyol fatty acids, isohexadecane, isopropyl palmitate, mixtures of C13-C14 isoparaffins and polyacrylamide and laureth-7, or combinations thereof; and (c) from about 0.1% to about 99.9% by weight of a topical vehicle.

9. The composition according to claim 8, further characterized in that the fatty acid portion contains from about 8 to about 18 carbon atoms.

10. The composition according to claim 8, further characterized in that the polyol portion is selected from the group consisting of erythritol, xylitol, sorbitol, glucose, sucrose, and mixtures of the mims. 1.

The composition according to claim 10, further characterized in that the polyol portion is sucrose.

12. The composition according to claim 1, further characterized in that the liquid polyol fatty acid polyester has a melting point of about -30 ° C to about 25 ° C.

13. The composition according to claim 8, further characterized in that the liquid oil has a melting point of about -30 ° C to about 25 ° C.

14. The composition according to claim 13, further characterized in that the liquid oil is selected from the group consisting of mineral oil, hydrocarbons having from about 5 to about 16 carbon atoms, fatty alcohol esters having from about 3. to about 22 carbon atoms, fatty acid esters having from about 3 to about 30 carbon atoms, vegetable oils, and mixtures thereof.

15. The composition according to claim 8, further characterized in that the topical vehicle is an oil-in-water emulsion.

16. The composition according to claim 8, further characterized in that the topical vehicle is an anhydrous liquid solvent.

17. The composition according to claim 8, further characterized in that the composition is in the form of a hand lotion, body lotion, skin conditioning cream, skin protector, sunscreen, skin cream, composition against acne, skin regenerating product, non-foaming cleansing lotion, moisturizer, facial moisturizer, makeup, foundation, lipstick, lip balm, hand cleaner, face cleanser, body cleanser, bath product, shampoo , and mixtures thereof.

18. A method for treating hair or skin of humans comprising topically applying to a human in need of treatment a safe and effective amount of a composition in accordance with claim 1.

19. A method for treating hair or hair human skin comprising topically applying to a human in need of treatment a safe and effective amount of a composition according to claim 8.