MXPA97003896A - Topical compositions for care of the skin containing esters of carboxylic acid of non-oclusive liquid polyol as agents of conditioning of the p - Google Patents

Abstract

The present invention relates to skin care compositions comprising a skin conditioning agent and the topical vehicle for the skin conditioning agent, the skin conditioning agent comprising certain non-occlusive liquid polyol carboxylic acid esters, those which the ester has a full melting point of less than about 30 ° C, these compositions provide excellent benefits of conditioning the pi

Description

TOPICAL COMPOSITIONS FOR THE SKIN SKIN CONTAINING NON-OCLUSIVE LIQUID POLYOL ACID ESTERS OF OCCLUSIVE LIQUID CONDITIONING AGENTS TECHNICAL FIELD The present invention relates to skin care compositions containing a skin conditioning agent comprising a non-occlusive liquid polyol carboxylic acid ester, having a complete melting point of less than about 30 ° C and a topical vehicle for the skin conditioning agent.

BACKGROUND OF THE INVENTION For many years, the treatment of human skin with different agents has been undertaken in order to keep the skin in a soft and flexible condition. The skin has a tendency to dry out when exposed to low humidity or harsh detergent solutions for prolonged periods. From a physiological point of view, dryness is a measure of the water content of the skin. Under normal conditions, the water content and the vapor pressure of the epidermis are greater than those of the surrounding air, with consequent evaporation of water from the surface of the skin. The skin becomes dry due to excessive loss of water from its surface, which results in water loss from the stratum corneum. Low humidity accelerates this process, exacerbating the dryness of the skin. The continuous and prolonged immersion in solutions of soap or detergent can contribute to the dryness of the stratum corneum. The reason for this is that the surfactant medium promotes dissolution of the surface of the skin and lipids of the stratum corneum, and the dissolution of water-soluble hygroscopic components in the skin. In attempts to improve or avoid the aforementioned conditions, many different emollient materials have been suggested for topical application to the skin. See for example, Sagarin Cosrnetics, Science and Technology, 28th edition, vol. 1, pgs. 34-36 (1972). It is believed that skin conditioning agents increase the hydration status of the skin by altering the rate of water diffusion from the lower epidermal and dermal layers, the rate of water evaporation from the skin surface, and the ability of the skin to corneous layer to retain moisture. Various materials are proposed as effective skin conditioners. See CTFfl Cosmetic Ingredient Haok, second edition., 1992. However, the most effective and widely used materials, such as glycerol, have negative aesthetic qualities, such as greasy or sticky qualities. Conversely, materials with better aesthetics tend to be ineffective as skin conditioners. Additionally, European Patent No. 458,600 Bl, published on March 2, 1994, discloses skin care occlusive compositions containing a polyol fatty acid polyester having at least 4 free hydroxyl groups, so less than 60% of which are located with one or more fatty acids having from 8 to 22 carbon atoms. However, these compositions have the disadvantage of being heavy and occlusive, thereby obtruding the pores of the skin and preventing the flow of oxygen. Therefore, there is a need for materials that can cover both criteria, efficacy and aesthetics, without being heavy or occlusive. Such materials would find immediate application, for example, in a wide variety of skin care compositions. It has been found in the present invention that skin care compositions containing certain liquid, non-occlusive polyol carboxylic acid esters, as a skin conditioning agent, provide a skin conditioning benefit without the negative aesthetic effects nor the undesirable occlusive effects mentioned herein. An object of the present invention is to provide skin conditioning agents comprising non-occlusive liquid polyol carboxylic acid esters having excellent aesthetic and skin conditioning properties. Another object of the present invention is to provide skin care compositions containing these non-occlusive skin conditioning agents which contain liquid polyol carboxylic acid esters, so that these compositions possess excellent aesthetic and skin conditioning properties. These and other objects will become readily apparent from the detailed description that follows.

BRIEF DESCRIPTION OF THE INVENTION The present invention relates to a topical skin care composition comprising: a) from about 0.1% to about 99.9% of a skin conditioning agent comprising: a non-occlusive liquid polyol carboxylic acid ester having a portion of polyol and at least 2 portions of carboxylic acid, wherein the polyol portion is selected from the group consisting of sugars and sugar alcohols containing from about 4 to about 11 hydroxyl groups, and wherein each portion of acid carboxylic acid has from about 8 to about 22 carbon atoms, and wherein said non-occlusive liquid polyol carboxylic acid ester has a complete melting point of less than about 30 ° C; and b) from about 0.1% to about 99.9% of a topical vehicle for said skin conditioning agent. All percentages and ratios used herein are by weight and measurements were made at 25 ° C, unless otherwise indicated. About this, the invention may comprise, consist of, or consist essentially of, the fundamental ingredients and components as well as the optionals described herein.

DETAILED DESCRIPTION OF THE INVENTION The term "topical skin care composition", as used herein, means a composition suitable for application on the surface of human skin. The term used encompasses a great variety of compositions for personal care, beauty care and cosmetics. Non-limiting examples of topical skin care compositions include, skin conditioning lotions and creams, skin protecting compositions, hand and body lotions, sunscreen compositions, anti-acne compositions, skin renewal products, masks, bases, makeup, lipsticks, lip protectors, cleansers, and the like. The term "non-occlusive", as used herein, means that the described material does not obstruct the surface of the skin or block the passage or circulation of air and moisture. The term "skin conditioning agent", as used herein, means a material that provides a "skin conditioning benefit". As used herein, the term "skin conditioning benefit" means providing a therapeutic or cosmetic benefit to the skin including, but not limited to, moisturization, which is the ability to retain water or moisture in the skin, emolliency. , visual improvement of the surface of the skin, smooth feeling of the skin, softness of the skin, scarring of cuts, abrasions and minor burns of the skin, and the like. The above terms are all included under skin conditioning because a skin conditioning agent can provide one or more of these listed benefits, or other related benefits. The term "topical vehicle", as used herein, is well known to persons of ordinary skill in the art, and means one or more compatible, solid or liquid filler diluents, or vehicles, which are suitable for administration to a human. The term "compatible", as used herein, means that the components of the topical vehicle are capable of mixing with the components of the present invention and with each other, such that there is no interaction that substantially reduces the effectiveness or aesthetics of the skin conditioning composition under situations of ordinary use. The topical vehicle must be a pharmaceutically acceptable vehicle. The term "pharmaceutically acceptable" as used herein means that the topical carrier must be of sufficiently high purity and be suitable for use in contact with human skin, without toxicity, incompatibility, instability, allergic response or similar undue reactions. The term "complete melting point", as used herein, means a melting point determined by the well known technique of Differential Scanning Calorimetry (DCS). The full melting point is the temperature at the intersection of the baseline, that is, the specific heat line, with the tangent of the line to the trailing edge of the endothermic peak. Typically, a scrubbing temperature of 5 ° C / minute is used in the present invention to measure the full melting points. A technique for measuring complete melting points is described more fully in the U.S. Patent. No. 5,306,514 to Letton et al., Issued April 26, 1994, which is hereby incorporated by reference in its entirety.

SKIN CONDITIONING AGENT The present invention comprises from about 0.1% to about 99.9% by weight, preferably from about 0.5% to about 20%, and preferably from about 1% to about 10% by weight of the skin conditioning agent. not occlusive The skin conditioning agent comprises a non-occlusive liquid polyol carboxylic acid ester. These polyol esters are derived from a radical or portion of polyol and one or more radicals or portions of carboxylic acid. In other words, these esters contain a portion derived from a polyol and one or more portions derived from a carboxylic acid. These carboxylic acid esters can also be described as liquid polyol fatty acid esters, because the terms carboxylic acid and fatty acid are frequently used interchangeably by those skilled in the art. The liquid polyol polyesters employed in this invention comprise certain polyols, especially sugars or sugar alcohols, esterified with at least two fatty acid groups. The polyol starting material, however, preferably has at least about 4 esterifiable hydroxyl groups. Examples of preferred polyols are sugars, including monosaccharides and disaccharides, and sugar alcohols. Examples of monosaccharides containing four groups > The hydroxyl are xylose and arabinose and the sugar alcohol derived from xylose, which has five hydroxyl groups, i.e. xylitol. The monosaccharide erythrose is also suitable in the practice of this invention since it contains three hydroxyl groups, such as the sugar alcohol derived from erythrose, ie, erythritol, which contains four hydroxyl groups. Suitable monosaccharides that contain five hydroxyl groups are galactose, fructose, and sorbose. Also suitable are sugar alcohols containing 6 hydroxyl groups derived from the products of hydrolysis of sucrose, as well as glucose and sorbose, for example, sorbitol. Examples of disaccharide polyols that can be used include maltose, lactose, and sucrose, all of which contain eight hydroxyl groups. The polyols used in the non-occlusive liquid polyol esters of the present invention preferably have from about 4 to about 12, preferably from about 4 to about 11, and preferably from about 4 to about 8 hydroxyl groups. The preferred polyols for preparing the polyesters for use in the present invention are selected from the group consisting of erythritol, xylitol, sorbitol, glucose and sucrose. Sucrose is especially preferred. The preferred polyol starting material which has at least four hydroxyl groups must be esterified in at least two of the hydroxyl groups with a fatty acid containing from about 8 to about 22 carbon atoms, preferably from about 8 to about 14 carbon atoms. Examples of such fatty acids include caprylic, capric, lauric, myristic, myristoleic, palmitic, palmitoleic, stearic, oleic, ricinoleic, linoleic, linoleic, eleseaaric, arachidonic, behenic, and erucic acids. Fatty acids can be derived from naturally occurring or synthetic fatty acids; they can be saturated or unsaturated, including positional and geometric isomers. However, to provide liquid polyesters of the type used herein, at least about half of the fatty acid incorporated in the polyester molecule must be unsaturated fatty acids, short chain saturated fatty acids, or mixtures thereof. The liquid polyol fatty acid polyesters useful in this invention should contain at least two fatty acid ester groups. It is not necessary that all hydroxyl groups of the polyol be esterified with fatty acids, but it is preferable that the polyester contains no more than two unesterified hydroxyl groups. Preferably, substantially all the hydroxyl groups of the polyol are etherified with fatty acids, ie, the polyol portion is substantially completely esterified. The fatty acids esterified with the polyol molecule can be the same or mixed, but as noted above, a substantial amount of the unsaturated acid ester, and / or short acid saturated acid ester groups must be present to impart properties of liquid. To illustrate the above points, sucrose fatty acid ester may be suitable, but it is not preferred because it has more than two unesterified hydroxyl groups. It would be preferred to have an ester of sucrose hexahydric acid, since it has no more than two hydroxyl groups without esterification. Highly preferred compounds in which all hydroxyl groups are etherified with fatty acids include the octa-substituted sucrose fatty acid esters. The following are non-limiting examples of non-occlusive liquid polyol fatty acid polyesters containing at least two fatty acid ester groups suitable for use in the present invention: glucose dioleate, the glucose diesters of fatty acids of soybean oil (unsaturated), the diesters of fatty acid mafia of mixed soybean oil, the galactose diesters of oleic acid, the diesters of lytic acid of arabinose, xylose dilinoleate, sorbitol dioleate, sucrose dioleate, glucose trioleate, glucose triesters of soybean oil fatty acids (unsaturated), fatty acid maleate triesters of mixed soya oil, galactose triesters of oleic acid, arabinose triesters of líneleic acid, xylose trilinoleate, sorbitol trioleate , sucrose trioleate, glucose tetraoleate, glucose tetraethers of fatty acids of soybean oil (intakes), tetra mixed fatty acid oil fatty acid ester esters, the galactose tetraesters of oleic acid, the tetraesters of arabinose of linoleic acid, tetralinoleate of xylose, pentaoleate of galactose, tetraoleate of sorbitol, the esters of sorbitol of fatty acids of unsaturated soybean oil, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose ectaoleate, sucrose octaoleate, and mixtures thereof.

The preferred liquid polyol polyesters of the present invention have melting points below approximately 30 ° C, preferably below about 27.5 ° C, and preferably below about 25 ° C. The complete melting points reported herein are measured by Differential Scanning Calorimetry (DSC). The polyol fatty acid polyesters suitable for use herein can be prepared by a variety of methods well known to those skilled in the art. These methods include: transesterification of the polyol with fatty acid esters of methyl, ethyl or glycerol, using a variety of catalysts; acylation of the polyol with a fatty acid chloride; acylation of the polyol with fatty acid anhydride; and acylation of the polyol with a fatty acid, per se. See U.S. Patent No. 2,831,854, U.S. Patent. . DO NOT. 4,005,196. for Jandacek, issued on January 25, 1977 and US Patent. . No. 4,005,196 to Jandacek issued on January 25, 1977, all of which are hereby incorporated herein by reference.

TOPICAL VEHICLE The present invention comprises from about 0.1% to about 99.9%, preferably from about 50% to about 99%, and most preferred from about 60% to about 95%, by weight of a topical vehicle for the conditioning agent of the skin and for any other optional component of the present invention. Skin conditioning agents of the present invention can be formulated in a wide variety of product types, including creams, lotions, milk extracts, mousses, gels, lotions, toners, sprays, hand and body lotions, moisturizing creams, lotions cleansers, facial moisturizers, sunscreens, anti-acne preparations, topical analgesics, mascaras, lipsticks, and the like. The vehicles and any additional components required to formulate such products vary with the type of product and can be routinely chosen by a person skilled in the art. The topical vehicle can be in a wide variety of forms. For example, emulsion vehicles, including, but not limited to, oil-in-water emulsions, water-in-oil-in-water emulsions, and silicone water-in-water emulsions are useful herein. These emulsions can encompass a broad scale of viscosities, for example, from about 100 cps to about 200,000 cps. These emulsions can also be supplied in the form of sprinklers using mechanical pump containers or aerosol containers subjected to pressure using conventional propellants. These vehicles can also be supplied in the form of an ousse. Other suitable topical vehicles include anhydrous liquid solvents such as oils, alcohols, and silicones (e.g., mineral oil, ethanol, isopropanol, dimethyone, cyclomethicone, and the like); aqueous liquid solvents based on individual phase (for example, hydro-alcoholic solvent systems); and thickened versions of these anhydrous and aqueous solvents based on individual phase (for example, where the viscosity of the solvent has been increased to form a solid or is i-solid by the addition of gums, resins, waxes, polymers, salts, and Similar). Examples of topical vehicle systems useful in the present invention are described in the following references which are incorporated herein by reference in their entirety: "Sun Products Formulary" Cos etics R Toiletries, vol. 105, pp. 122-139 (December 1990); "Sun Products Fornulary" Cosmetics a Toiletries, vol. 102, pp. 117-136 (March 1987); Patent of E.U.A. No. 4,960,764, to Fi? Eroa et al., Issued October 2, 1990; Patent of E.U. . No. 4,254,105, to Fukuda et al., Issued March 3, 1981; Patent of E.U. . No. 4,976,953, to Orr et al., Issued December 11, 1990; and Patent of E.U.A. No. 5,073,372, to Turner and others, issued December 17, 1991. When the topical skin conditioning agent is an aerosol spray or mousse, the vehicle may also use any of the conventional propellants to deliver the material as a foam (in the case of a mousse) or as a uniform, fine sprinkler (in the case of an aerosol). Examples of suitable propellants include materials such as trichloro-fluoromethane, dichlorodifluoromethane, difloromethane, di-ethyl ether, propane, n-butane or isobutane. A more complete description of propellants useful herein can be found in Sagarin, Cosrnetics Science and Technology, 23 edition, vol. 2, pp. 443-465 (1972), which is incorporated herein by reference. Suitable spray containers are well known in the art and include conventional, non-rosin pump sprinklers, ie, "sprayers", containers or spray cans having propellant, as described above, and also pump spray containers using compressed air as the propeller. Pump aerosol containers are described, for example, in US Patents. Nos. 4,077, 441 March 7, 1978, Olofsson and 4,850,577, July 25, 1989, both incorporated herein by reference, and also in U.S. Pat. Series No. 07 / 839,648, Gosselin, Lund, Sojka and Lefebvre, filed on February 21, 1992, "Consumer Product Package Incorporating A Spray Device Utilizing Large Diameter Bubblee". The hair pump aerosol sprays using compressed air are also currently manufactured by The Procter 8 Gamble Company under its registered brand of hair sprays VIDAL SASSOON HAIRSPRAY.

ADDITIONAL COMPONENTS A wide variety of additional components may be employed in the topical skin conditioning compositions herein. Non-limiting examples include the following: Pharmaceutical Assets The compositions of the present invention may comprise a safe and effective amount of a pharmaceutical active. The phrase "safe and effective amount", as used herein, means an amount of active n? N sufficiently high to modify in a significant or positive manner the condition to be treated, but sufficiently low to avoid serious side effects (a a reasonable benefit / risk ratio), within the scope of the medical judgment. A safe and effective amount of the pharmaceutical active will vary with the specific asset, the ability of the composition to penetrate the active through the skin, the amount of composition to be applied, the particular condition being treated, the age and condition the patient's physical condition being treated, the severity of the condition, the duration of the treatment, the nature of the concurrent therapy, and similar factors. The pharmaceutical actives that can be used in the compositions of the present invention preferably comprise from about 0.1% to about 20% by weight of the compositions, more preferably from about 0.1% to about 10%, and most preferred from about 0.1% to approximately 5%. Mixtures of pharmaceutical active ingredients can also be used. Non-limiting examples of pharmaceutical actives may include the following: Pharmaceutical actives useful in the compositions of the present invention include anti-acne drugs. Anti-acne drugs for use in the present invention include the ceratotics such as salicylic acid, sulfur, lactic acid, glycolic acid, pyruvic acid, resorcinol, and N-acetylcysteine; re inoi is such as re-inoic acid and its derivatives (eg, cis and trans); antibiotics and antimicrobials such as benzoyl peroxide, octopirox, erythromycin, zinc, tetracycline, triclosan, azelaic acid and its derivatives, phenoxyethanol and phenoxypropanol, ethylacetate, clindamycin and meclocycline; seboestáticos such as flavinoides; alpha and beta hydroxy acids; and bile salts such as scymnol sulfate and its derivatives, deoxycholate, and cholate. Preferred anti-acne actives are those selected from the group consisting of salicylic acid, sulfur, resorcinol, lactic acid, zinc, erythromycin, benzoyl peroxide, and mixtures thereof. The most preferred is salicylic acid. The pharmaceutical actives in the compositions of the present invention include non-steroidal anti-inflammatory drugs (NSAIDS). The NSAIDS can be selected from the following categories: propionic acid derivatives; acetic acid derivatives; Phenaric acid derivatives; biphenylcarboxylic acid derivatives; and oxicarns. All of these NSAIDS are fully described in the U.S. Patent. . 4,985,459 to S? Nshine et al., Issued January 15, 1991, incorporated herein by reference. More preferred are propionic NSAIDS including, but not limited to, aspirin, aceofen, ibuprofen, naproxen, benoxaprofen, flurbiprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, rniroprofen, thioxaprofen, suprofen, in inoprofen, acid thiaprofenic, fluprofen and b? clóxico acid. Steroidal antiinflammatory drugs including hydrocortisone and the like are also useful. Pharmaceutical actives useful in the compositions of the present invention include antiprictic drugs. Preferred antiprictic drugs for inclusion in the compositions of the present invention include pharmaceutically acceptable salts of metdilizine and trimeprazine. The pharmaceutical actives useful in the compositions of the present invention include anesthetic drugs. Preferred anesthetic drugs for inclusion in the compositions of the present invention include pharmaceutically acceptable salts of lidocaine, bupivacaine, chlorprocaine, dib? Caine, etidocaine, mepivacaine, tetracaine, diclionine, hexylcaine, procaine, cocaine, ketamine, praoxin and phenol.

The pharmaceutical actives useful in the compositions of the present invention include antirnicrobial drugs (antibacterial, antifungal, antiprotozoal and antiviral drugs). Preferred antimicrobial drugs for inclusion in the compositions of the present invention include pharmaceutically acceptable salts of b-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, ephythmycin, icacma, tpclosan, doxycycline, capreromic, chlorhexidine. , chlortetracycline, oxytetracycline, clmdamicin, eta butol, and ronidazole, pentanidine, gentamicin, cana icine, lmeo icine, etacycline, minocycline, neocyst, netilmicm, omicin, streptomycin, tobra icina, iconazola and amphama. Preferred anti-microbial drugs for inclusion in the compositions of the present invention include tetracycline hydrochloride, entromycin estolate, entromicin (salt) stearate, amicacma sulfate, doxycycline hydrochloride, caffeine sulfate, chlorhexidine gluconate, hydrochloride chlorhexidine, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clmdamicin hydrochloride, ethambutol hydrochloride, metromdazole hydrochloride, pentamidine hydrochloride, genta icma sulfate, cannabis sulfate, lineochromic hydrochloride, metacyclic hydrochloride, methanamine hippurate, metnamma, inocicline hydrochloride, neomycin sulfate, netilmicma sulfate, paromomicma sulfate, streptomycin sulfate, tobramycin sulfate, miconazole hydrochloride, ananfadine hydrochloride, amanfadine sulfate, triclosan, octopirox, parachlorometre xylenol, nystatin, tolnaftate and clotrimazole. Here too, sunscreen agents are useful. A wide variety of sunscreen agents are described in the U.S. Patent. No. 5,087,445, to Haffey et al., Issued February 11, 1992; Patent of E.U. . No. 5,073,372, to Turner et al., Issued December 17, 1991; Patent of E.U.A. No. 5,073,371, to T? Rner et al., Issued December 17, 1991; and Segarin et al., in Chapter VIII, pages 189 et seq., of Cosmetics Science and Technology, all incorporated herein by reference in their entirety. Preferred sunscreens which are useful in the compositions of the present invention are those selected from the group consisting of 2-ethylhexyl p-methoxycinnam or, 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, p-arninobenzoic acid, 2-phenylbenzimidazole-5-sulphonic acid, octocrylene, oxybenzone, homobutyl salicylate, octyl salicylate, 4,4'-methoxy-t-butyldibenzoylmethane, 4-isopropyl dibenzoylmethane, 3-benzyldene camphor, 3- (3-camphor 4- ethylbenzyldene), titanium dioxide, zinc oxide, silica, iron oxide, and mixtures thereof. Still other useful sunscreens are those described in the U.S. Patent. No. 4,937,370, to Sabatelli, issued June 26, 1990; and the U.S. Patent. Do not. 4,999,186, to Sabatelli et al., Issued March 12, 1991; These two references are incorporated herein by reference in their entirety. The sunscreen agents described therein have, in a single molecule, two distinct chromophore portions that exhibit different absorption spectrum of ultra-violet radiation. One portion of chromophore absorbs predominantly on the UVB radiation scale and the other absorbs strongly on the UVA radiation scale. These sunscreen agents provide greater efficiency, wider UV absorption, less skin penetration and more durable efficacy with respect to conventional sunscreens. Preferred examples especially of these sunscreens include those selected from the group consisting of 4-N, N- (2-ethylhexyl) methyl-aminobenzoic acid ester of 2,4-dihydroxybenzophenone, 4-N, N-acid ester - (2-ethylhexyl) methylaminobenzoic acid with 4-hydroxydibenzoyl-methane, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, 4-N, N- (2-ethylhexyl) -methylaminobenzoic acid ester of 4- ( 2-hydroxyethoxy) ibenzoylmethane, and mixtures thereof. In general, sunscreens may comprise from about 0.5% to about 20% of the compositions useful herein. The exact amounts will vary depending on the chosen sunscreen and the Sun Protection Factor (? PF). SPF is a commonly used measure of photoprotection of a sunscreen against erythema. See, Federal Register, vol. 43, No. 166, pp. 38260-38269, August 25, 00 1978, which is incorporated herein by reference in its entirety. Artificial bronzing agents are also useful in the present invention including dihydroxyacetone, glyceraldehyde, indoles and their derivatives, and the like. These artificial tanning agents can also be used in combination with sunscreen agents. Other useful actives include skin whitening (or lightening) agents including, but not limited to, hydroquinone, aecorbic acid, konic acid, and sodium metabisulfite.

Conventional Wetting and Moistening The compositions of the present invention may also contain one or more wetting or moistening materials. A variety of these materials may be employed and each may be present at a level of from about 0.1% to about 20%, more preferably from about 1% to about 10%, and most preferred from about 2% to about 5% . These materials include guanidine; glycolic acid and glycolate salts (for example, ammonium and quaternary alkylammonium); lactic acid and lactate salts (for example, ammonium and quaternary alkylammonium); zabila in any of its variety of forms (for example, zabila gel); polyhydroxy aols such as sorbitol, glycerol, hexanetriol, propylene glycol, butylene glycol, hexylene glycol and the like; polyethylene glycols; sugars and starches; sugar and starch derivatives (eg, alkoxylated glucose), hyaluronic acid; lactate monoethanolamine; acetamide monoethanolamine; and mixtures thereof.

Emulsifiers The compositions herein may contain various emulsifiers. These emulsifiers are useful for emulsifying the different vehicle components of the compositions herein. Suitable emulsifiers can include any of a wide variety of nonionic, cationic, anionic and zwitterionic emulsifiers described in the above patents and other references. See, Detergents and Emulsifiers by McC? Tcheon, North American Edition (1986), published by Allured P? Blishing Corporation; Patent of E.U. . No. 5,011,681, to Ciotti et al., Issued April 30, 1991; Patent of E.U. . No. 4,421,769, to Dixon et al., Issued December 20, 1983; and Patent of E.U.A. No. 3,755,560, to Dickert et al., Issued August 28, 1973; These four references are incorporated herein by reference in their entirety. Suitable types of emulsifier include glycerin esters, propylene glycol esters, polyethylene glycol fatty acid esters, polypropylene glycol fatty acid esters, sorbitol esters, sorbitan anhydrous esters, carboxylic acid copolymers, esters and ethers of glucose, ethoxylated ethers, ethoxylated aols, alkyl phosphates, polyoxyethylene fatty ether phosphates, fatty acid amides, acyl lactiates, soaps and mixtures of the same. Suitable emulsifiers may include, but are not limited to, polyethylene glycol sorbitan 20 monolaurate (Polysorbate 20), polyethylene glycol soybean 5, Steareth-20, Ceteareth-20, methyl glucose ether distearate from PPG -2, Ceteth-10, Polysorbate 80, cetyl phosphate, potassium keta phosphate, potassium diethanolamine phosphate, Polysorbate 60, glyceryl stearate, PEG-100 stearate, and mixtures thereof. The e-energizers may be used individually or as a mixture of two or more and may comprise from about 0.1% to about 10%, more preferably from about 1% to about 7%, and most preferred from about 1% to about 5%. % of the compositions of the present invention.

Carboxylic Acid Copolymer Thickeners Another useful component in the compositions herein is a carboxylic acid copolymer thickener.

These interlaced polymers contain one or more monomers derived from acrylic acid, substituted acrylic acids, and salts and esters of these acrylic acids and substituted acrylic acids, wherein the crosslinking agent contains two or more carbon-carbon double bonds and is derived from a polyhydric alcohol. Preferred polymers for use herein are of two general types. The first type of polymer is an entangled honopolymer of an acrylic acid monomer or derivative thereof (for example, wherein the acrylic acid has two or three carbon moieties independently selected from the group consisting of C1 alkyl). -4, -CN, -COOH, and mixtures thereof). The second type of polymer is an interlaced copolymer having a first monomer selected from the group consisting of an acrylic acid monomer or derivative thereof (as just described in the previous sentence), an acrylate ester monomer (s). said C1-4) of short chain alcohol or derivative thereof (eg, wherein the acrylic acid portion of the ester has substituents at the positions of two or three carbons selected independently from the group consisting of C1-4 alkyl, -CN, -COOH, and mixtures thereof), and mixtures thereof; and a second monomer which is an acrylate ester (i.e., Cß-40) monomer of long chain alcohol or derivative thereof (eg, wherein the acrylic acid portion of the ester has substituents at the two positions). or three carbons selected from the group q? e consists of Ci-4 alkyl, -CN, -COOH, and mixtures thereof). The combinations of these two types of polymers are also useful herein. In the first type of interlaced homopolymer, the monomers are preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid being the most preferred. In the second type of entangled copolymers, the acrylic acid monomer or derivative thereof is preferably selected from the group consisting of acrylic acid, methacrylic acid, ethacrylic acid, and mixtures thereof, with acrylic acid, methacrylic acid being more preferred. and mixtures thereof. The short chain alcohol acrylate ester monomer or derivative thereof is preferably selected from the group consisting of alcohol acrylate esters of C? - ", alcohol methacrylate esters of C1-, ethacrylate esters C.sub.1-4 alcohol, with C1-4 alcohol acrylate esters, alcohol methacrylate esters of CI-A, and mixtures thereof being more preferred. The long-chain alcohol acrylate ester monomer is selected from C-40 alkyl acrylate esters, with C20-30 alkyl acrylate esters being most preferred. The crosslinking agent in both types of polymers is a polyalkenyl polyether of a polyhydric alcohol containing more than one alkylene ether group per molecule, wherein the polyhydric alcohol of origin contains at least 3 carbon atoms and at least 3 carbon atoms. hydroxyl groups. Preferred crosslinkers are those selected from the group consisting of allylic ethers of sucrose and alkyl ethers of pentaeptptol, and mixtures thereof. These polymers useful in the present invention are described more fully in the U.S. Patent. No. 5,087,445, to Haffey et al., Issued February 11, 1992; Patent of E.U. A. No. 4,509,949, to H? Ang and others, issued April 5, 1985; Patent of E.U.A. No. 2,798,053, to Brown, issued July 2, .1957; which are incorporated herein by reference. See also, CTFA International Cosrnetic Ingredient Dictionary, fourth edition, 1991, pp. 12 and 80; which is also incorporated herein by reference. Examples of commercially available homopolymers of the first type useful herein include carborneros, which are homopolymers of acrylic acid entangled with allylic ethers of sucrose or pentaepritol. The carborneros are available as the Carbopol * 900 series from B.F. Goodrich. Examples of commercially available copolymers of the second type useful herein include copolymers of C 1 or C 30 alkyl acrylates with one or more acrylic acid monomers, methacrylic acid, or one of its esters (ie, C alcohol? -4) of short chain, wherein the interlacing agent is an allyl ether of sucrose or pentaerythritol. These copolymers are known as interlaced polymers of acrylates / C10-10 alkyl acrylate and are commercially available as Carbopol * 1342, Pemulen TR-1, and Pemulen TR-2, from B.F. Goodrich.

In other words, examples of carboxylic acid polymer thickeners useful herein are those selected from the group consisting of carbomers, interlaced polymers of acrylates / C 10-10 alkyl acrylate, and mixtures thereof. The compositions of the present invention may comprise from about 0.025% to about 1%, more preferably from about 0.05% to about 0.75%, and most preferred from about 0.10% to about 0.50% of the carbohydrate polymer thickeners ilico Oils The compositions of the present invention may also optionally comprise various oil materials, that is, a material that generally has low solubility in water, generally less than about 1% by weight at 25 ° C. Examples of suitable oil components include, but are not limited to, volatile and non-volatile silicone oils, highly branched hydrocarbons, and non-polar alcohol and carboxylic acid esters, and mixtures thereof. The oils useful in the present invention are further described in the U.S. Patent. No. 4,919,934, to Deckner et al., Issued April 24, 1990, which is incorporated herein by reference in its entirety. Volatile silicone components such as cyclic polydimethylsiloxanes containing from about 3 to about 9 silicone atoms, and dimethicone are useful herein. Non-volatile silicones include polyalkylsiloxanes and polyalkyl-arylsiloxanes. Useful volatile and nonvolatile silicones are described in the U.S. Patent. . No. 5,069,897, to Orr, issued December 3, 1991, which is incorporated herein by reference in its entirety.

Other Additional Components The compositions of the present invention may comprise a broad scale of other additional components. The CTFA Cosmetic Ingredient Handbook, Second Edition, 1992, which is incorporated herein by reference in its entirety, discloses a wide variety of non-limiting cosmetic and pharmaceutical ingredients commonly used in the skin care industry, which are suitable for used in the compositions of the present invention. Non-limiting examples of functional classes of ingredients are described on page 537 of this reference. Examples of these functional classes include: absorbers, abrasives, anti-acne agents, anti-caking agents, anti-spreading agents, anti-microbial agents, antioxidants, binders, biological additives, regulating agents, dough forming agents, chemical agents, chemical additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, external analgesics, film formers, fragrance components, humectants, opacifying agents, pH adjusters, plastifiants, preservatives, propellants, agents reducers, additional skin conditioning agents, skin protectants, solvents, suspending agents (not surfactant), ultraviolet light absorbers, any agent that increases viscosity (aqueous and non-aqueous). Examples of other functional classes of materials useful herein which are well known to one skilled in the art include emulsifiers, solubilizant.es agents, and sequestrants, and the like. Non-limiting examples of these additional components cited in the CTFfl Cosmetic Ingredient Handbook, as well as other materials useful herein, include the following: vitamins and derivatives thereof C for example, vitamin C, vitamin A, (i.e., retinoic acid) , retinol, retinoids, and the like]; anti-oxidants; polyethylene glycols and polypropylene glycols; polymers to assist in the properties of film formation and subetantivity of the composition (such as a copolymer of eicoeeno and vinylpyrrolidone, an example of which is available from GAF Chemical Corporation as GanexR V-220); preservatives to maintain the microbial integrity of the compositions; antioxidants; chelators and kidnappers; non-ionic and cationic, interlaced and non-interlaced polyacrylamides C for example, Saleare SC92 q? e has the designation CTFA polyquaternium 32 (y) mineral oil, and Saleare SC 95 which has the designation CTFA polyquaterniu 37 (y) mineral oil (and ) PPG-1 trideceth-6, and the non-ionic Seppi-Gel polyacrylamides available from Seppic Corp.]; and aesthetic components such as fragrances, pigments, colorant, essential oils, skin sennates, astringents, skin softening agents, skin healing agents, and the like, non-limiting examples of these aesthetic components include spice clove oil, rnentol , camphor, eucalyptus oil, eugenol, menthyl lactate, hornbeam distillation liquid, bisabolol. , dipotassium glycyrhizinate and the like.

METHODS OF SKIN CONDITIONING The skin conditioning compositions of the present invention are used in conventional ways to provide a skin conditioning benefit, and to provide any cosmetic and pharmaceutical benefits appropriate to the product, such as protection against sun, anti acne benefits, anti wrinkle and anti aging skin benefits; artificial tanning, analgesic and similar benefits. Such methods of use depend on the type of composition employed but generally involve the application of an effective amount of the product to the skin. By "effective amount" is intended to mean any amount sufficient to provide the desired benefit. The typical amounts of the compositions of the present invention that are applied to the skin vary depending on the type of composition and the benefit desired. However, typical scales are generally from about 0.1 rng / cm2 to about 25 rng / cm2, with approximately 2 rng / cm2 being typical.

EXAMPLES The following examples describe more fully and demonstrate embodiments within the scope of the present invention. The examples are given by way of illustration only and should not be considered as limitations of the present invention, since many variations thereof are possible without departing from the spirit and scope of the invention. The ingredients are identified by their chemical or CTFA name.

EXAMPLE 1 Humidifier A humidifier is prepared by combining the following ingredients using conventional mixing techniques.

Ingredients Percent by weight Water cbp 100 Cetyl alcohol 1.80 Stearic acid 0.25 Stearyl alcohol 1.20 Peg 100-stearate 0.25 Mineral oil 2.00 Petrolatum 1.50 Isopropyl Palmitate 1.00 Cetyl Ricinoleate 1.00 Liquid Sucrose Polyester * 2.00 Dimethicone 3502 0.50 Propylparaben 0.10 Arlatone (RTM) 21213 1.00 Glycerin 9.00 Urea 2.00 Octyl methoxy cinnamate 2.00 Phenoxyethanol 0.25 Carbomer 1382 * 0.05 Carbomer 545 0.35 Trisodium EDTA 0.10 Titanium dioxide 0.15 Methylparaben 0.20 NaOH 0.22 Dirnethicone 0-214036 1. 00 i Esters of hexa-, hepta- and octa-sucrose, predominantly the ester-octa esterified with fatty acids of mixed soybean oil. 200 Dow Corning Fluid * (350 centistoke) from Dow Corning. 3 95% by weight of sorbitan stearate and 5% by weight of sucrose cocoate. 4 Carbopol * 1382 from B.F. Goodrich. s Carbopol * 954 from B.F. Goodrich. 6 0-2 1403 from Dow Corning of Dow Corning, which is a mixture of 85% by weight of dimethicone and 15% by weight of dimethylconal.

The composition is prepared as follows: A first premix of weighing agents, Arlatone 2121 and other water-soluble ingredients is prepared by mixing in water and heating. A second premix of oil phase ingredients other than the silicones is prepared by mixing and heating and added to the aqueous premix. The resulting mixture is cooled. The silicones are subsequently added to the resulting oil-in-water emulsion and the mixture is cooled before adding minor ingredients. The composition is ready to be packed. The composition is useful for topical application to the skin and displays improved wetting, skin feeling and skin care characteristics, together with a reduced fatty nature and excellent absorption characteristics by rubbing.

EXAMPLES 2-3 Moistening A humidifier is prepared by combining the following ingredients using conventional mixing techniques.

Percent by weight Ingredients Example 2 Example 3 Water cbp 100 - cbp 100 Cetyl Alcohol 1.80 1.80 Stearic acid 0.25 0.25 Stearyl alcohol 1.20 1.20 Peg 100-stearate 0.25 0.25 Mineral oil 2.00 Petroleum 1.50 1 1..5500 Isopropyl palmitate 1.00 1 1..0000 Cetyl Ricinoleate 1.00 1 1..0000 Liquid sucrose polyester1 2.00 4.00 Di ethicone 3502 0.50 0.50 Prspilparaben 0.10 0.10 Arlatone (RTM) 2121.3 i.rjO 1.00 Glycerin 9.00 9.00 Urea 2.00 2.00 Octyl methoxycinnamate 2.00 2.00 Phenoxyethanol 0.25 0.25 Carborner 1.3824 0.05 0.05 Carborner 9545 0.35 0.35 Trisodium EDTA 0.10 0.10 Titanium dioxide 0.15 0.15 Methylparaben 0.20 0.20 NaOH 0.22 0.22 Dimethicone 0-21403 * 1.00 1.00 i Esters of mixed liquid hexa-, hepta- and octa-sucrose, predominantly the ester-octa esterified with mixed fatty acids of soybean oil. 2 200 Fluid from Dow Corning "(350 centistoke) from Dow Corning 3 g 5 wt% sorbitan stearate and 5 wt% sucrose cocoate 4 Carbopol" 1382 from B.F. Goodrich. 5 Carbopol * 954 from B.F. Goodrich. 6 Dow Corning * 0-2 1403 from Dow Corning, which is a blend of 85% by weight of dimethicone and 15% by weight of dimethieonal.

The composition is prepared as follows: A first premix of thickeners, Arlatone 2121 and other water-soluble ingredients is prepared by mixing in water and heating. A second pre-mixture of oil phase ingredients other than the silicones is prepared by mixing and heating and added to the aqueous premix. The resulting mixture is cooled. The eylons are then added to the resulting oil-in-water emulsion and the mixture is cooled before adding minor ingredients. The composition is ready to be packed. These compositions are useful for topical application to the skin and display improved wetting, skin-feeling and skin-care characteristics, together with a reduced fattyness and excellent absorption characteristics by rubbing.

EXAMPLE 4 Sunscreen A sunscreen is prepared by combining the following ingredients using conventional mixing techniques.

Ingredients Percent by weight Water cbp 100 Octyl methoxy cinnamate 7.50 Octocrylene 3.75 Oxybenzone 2.00 1,3, Dihydroxyacetone .. 3.00 Polyester of sucrose thickened1 2.00 Butylene glycol 2.00 Saleare SC952 1.25 Ganex V-2203 1.00 Perrnethyl 101a * 1.00 Fragrance 0.50 Cetyl Palmitate 0.75 Synchrowax HRC5 0.75 Cetyl alcohol 0.50 Glydant plus 0.20 Varisoft TA-1005 0.20 Natrosol plus CS330? 0.20 EDTA disodium 0.05 1 Esters of mixed liquid hexa-, hepta- and octa-sucrose, predominantly the ester-octa esterified with fatty acids of mixed soybean oil. 2 Polyquaternium-37, mineral oil and PPG-1 trideceth-6, available from Allied Colloids, Norfolk, VA. 3 PVP / eicosene 4 Isohexadecane copolymer. 5 Tribehenin. 6 Distearildimony Chloride. 7 Cetyl hydroxyethylcellulose.

The composition is prepared as follows: A first premix of thickeners, and other water-soluble igredients is prepared by mixing in water and heating. A second pre-mixture of oil phase ingredients other than the silicones is prepared by mixing and heating and added to the aqueous premix. The resulting oil-in-water emulsion is cooled before adding minor ingredients. The composition is ready to be packed. This composition is useful for topical application to the skin as a sunscreen composition, and displays improved wetting, skin-feeling and skin-care characteristics, together with a reduced fatty nature and excellent absorption characteristics by rubbing.

EXAMPLE 5 Anti-Acne Gel An anti-acne gel is prepared by combining the following ingredients using conventional mixing techniques.

Ingredients Percent by weight Water cbp 100 Thickened sucrose polyester1 2.00 Benzoyl peroxide2 2.50 Carbomer 98O3 0.30 Glydant plus * .0.20 C10-305 acrylate / alkyl acrylate crosspolymer 0.05 Disodium EDTA 0.10 Stearyl alcohol 2.25 Cetyl alcohol 7 25 Glycerylhydroxy stearate 0.74 Steareth 100 0.50 Sucrose Polyester 2.50 Sodium Hydroxide 0.05 Dirneticone6 0.60 Cyclomethicone / dimethiconal 0.50 Esteree of hexa-, hepta- and octa-sucrose mixed liquids, predominantly the ester-octa esterified with fatty acids of mixed soybean oil. 2 Lucidol * 75 by Elf Atochem, which is a powder containing 75% active benzoyl peroxide. 3 Carbopol * 980 from B.F. Goodrich. 4 Hidantoin DMDM (and) iodopropynyl bicarbonate. s Pemulen * TR-1 of B.F. Goodrich. 6 200 Dow Corning Fluid * (350 centistoke) from Dow Corning. 7 0-2 1401 from Dow Corning *.

The composition is prepared as follows: In a suitable vessel a suspension of benzoyl peroxide is prepared by combining the benzoyl peroxide with water, which is equivalent to about 3.6% of the batch. This suspension is passed through a Colloid or Urschel mill to disperse the benzoyl peroxide and the mill is rinsed with an additional 1.44% water. The liquid is added to the total suspension. In a separate vessel prepare a 5% sodium hydroxide solution with water to provide sodium hydroxide to the mixture at 0.05%. In another container, the carborner 980 is gradually combined with a quantity of water, totaling 14.7% of the lot. This is added under agitation to disperse and hydrate the carbornero. In a suitable mixing tank, the remaining water is added and heated to at least 75 ° C. In a separate vessel add di-ethicone, cetyl alcohol, stearyl alcohol, glycerylhydroxy stearate, liquid sucrose polyester and steareth 100, and heat to at least 75 ° C. While the water phase is heated, disodium EDTA, glydant plus and alkyl acrylates are added and mixed until dissolved. When both phases reach the required temperature, the oil phase is slowly added to the water phase while the entire batch is recycled through a tekmar mill to reduce the particle size of the oil droplet to about one or two mieras. The batch is then cooled to room temperature under constant agitation. When the batch has cooled, the carbopol suspension, the benzoyl peroxide suspension and the cyclorketone / dirneticonal suspension are added. The batch is recycled again through the tekmar mill to disperse the materials. Finally, the 5% NaOH solution is added gradually with continuous mixing. The composition is subsequently mixed until homogeneous. This composition is useful for topical application to the skin as an anti-composition. acne, and displays improved moisturizing, skin-feeling and skin-care characteristics, together with a reduced fatty nature and excellent absorption characteristics by rubbing.

Claims (9)

NOVELTY OF THE INVENTION CLAIMS

1. - A topical skin care composition comprising: a) from about 0.1% to about 99.9% of a skin conditioning agent comprising: a non-occlusive liquid polyol carboxylic acid ester having a portion of polyol and at least two carboxylic acid moieties, wherein the polyol portion is selected from the group consisting of sugars and sugar alcohols containing from about 4 to about 11 hydroxyl groups, and wherein each carboxylic acid moiety has from about 8. to about 22 carbon atoms, and wherein said liquid and non-occlusive polyol carboxylic acid ester has a complete melting point of less than about 30 ° C; and b) from about 0.1% to about 99.9% of a topical vehicle for said skin conditioning agent.

2. A composition according to claim 1, wherein said non-occlusive liquid polyol carboxylic acid ester contains at least about 4 carboxylic acid moieties and no more than about 2 free hydroxyl groups.

3. A composition according to claim 2, wherein said carboxylic acid portions contain from about 14 to about 18 carbon atoms.

4. A composition according to claim 3, wherein said polyol portion is selected from the group consisting of erythritol, xylitol, sorbitol, glucose, sucrose and mixtures thereof.

5. A composition according to claim 4, wherein said polyol portion is sucrose.

6. A composition according to claim 1, comprising from about 0.5% to about 20% of said non-occlusive liquid polyol carboxylic acid ester and from about 50% to about 99% of said topical carrier.

7. A composition according to claim 1, comprising from about 1% to about 10% of said non-occlusive liquid polyol carboxylic acid ester and from about 60% to about 95% of said topical carrier. B. A composition according to claim 5, wherein said non-occlusive liquid polyol carboxylic acid ester has a complete melting point below about 27.5 ° C. 9. A composition according to claim 5, wherein said liquid polyol carboxylic acid ester has a complete melting point below about 25 ° C. 10. A composition according to claim 7, wherein said liquid polyol carboxylic acid ester is selected from the group consisting of sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate, sucrose octaoleate and mixtures thereof. . 11. A composition according to claim 1, which further comprises a pharmaceutical active selected from the group consisting of anti-acne drugs, non-steroidal antiinflammatory drugs, antipruritic drugs, anesthetic drugs, antimicrobial drugs, sunscreen agents, artificial tanning agents, skin bleaching agents and mixtures thereof. 12. A composition according to claim 11, wherein said active is a sunscreen agent selected from the group consisting of 2-ethylhexyl p-netoxcinnamate, 2-ethylhexyl N, N-dirnetii-p-arninobenzoate , p-aminobenzoic acid, 2-phenylbenzimidazole-5-sulfonic acid, octocrylene, oxybenzone, honomenthyl salicylate, octyl salicylate, 4,4'-methoxy-tb? tildibenzoylmethane, 4-isopropyl dibenzoylmethane, 3-benzylidene camphor, 3- (4-methylbenzylidene) camphor, titanium dioxide, zinc oxide, silica, iron oxide, 4-N, N- (2-ethehexyl) methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, acid ether -N, N- (2-ethylhexyD ethylaminobenzoic acid with 4-hydroxydibenzoylmethane), 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester of 2-hydroxy-4 ~ (2-nidroxyethoxy) benzophenone, 4-N, N- (2-ethylhexyD ethylaminobenzoic acid ester of 4- (2- hydro ietox i) dibenzoyl methane and mixtures thereof 13. A composition according to claim 1.1, wherein said active is an anti acne active selected from the group consisting of salicylic acid, sulfur, lactic acid, zinc, erythromycin, benzoyl peroxide and mixtures thereof 14. A composition according to claim 1, wherein said topical vehicle is an oil in water emulsion 15. A composition according to claim 1 , wherein said topical vehicle is an anhydrous liquid solvent 16. A method of skin conditioning in humans comprising topically applying a safe and effective amount of a composition according to claim 1 to a human in need of treatment. 17.- A method of a skin conditioning in humans comprising topically applying a safe and effective amount of a composition according to claim 2 to a human in need of treatment. 1

8. A method of skin conditioning in humans comprising topically applying a safe and effective amount of a composition according to claim 3 to a human in need of treatment. 1

9. A method of skin conditioning in humans comprising topically applying a safe and effective amount of a composition according to claim 4 to a human in need of treatment.