KR20000065345A - Composition of therapeutical agents for a burn - Google Patents

Abstract

PURPOSE: A composition containing herb medicine for treatment of burn is provided, which eliminates feeling of burn by fires and pain, and shows good skin-reproduction effect when applied on burn site as a preparation for external. CONSTITUTION: A process for the preparation of composition for treatment of burn comprises of: drying and pulverizing the Haooysitum Rubrum 40-44wt.%, the marble powder 20-23wt.%, the Yellow stone(Whang-Dan) 20-23wt.%. and the Rhei Rhizoma 10-14wt.% to fine powder, and mixing; adding pharmaceutically acceptable ointment base(e.g., Simple ointment, White ointment, Salicylated phenol ointment; Ichthammol ointment, Zinc oxide ointment) in the weight ratio of 5:5. The composition for treatment of burn is applied for 3-4-times per day on a burn site. A process for the preparation of Simple ointment comprises of: melting Yellow beeswax, vegetable oil on water bath completely; and mixing the compound till which be hard.

Description

Composition of therapeutical agents for a burn

The present invention relates to a composition for treating burns, and more particularly, to a composition for treating burns using a mixture of powders such as red stone paper, hanseok, yellow tablets and rhubarb.

In general, there are 7 kinds of herbs for herbal skin described in the oriental medicine as minerals such as sulfur, zeolite, cow sulfur, hard powder, podium, sensitized stone and borax. There have been two types, and they have been used for the treatment of oriental surgical skin diseases by appropriately selecting them and blending them in a predetermined ratio. If you refer to `` Oriental Surgery '', which is a collection of herbal medicine, Dongbobom (published in Korea in 1596) and recently published medicinal herbal medicine, about 1000 kinds of surgical external diseases are prescribed, and about 80 kinds of plaster prescription However, in these prescriptions, 11 kinds of medicines such as minerals, animals and plants mentioned above are prescribed in various kinds and ratios as raw medicines. However, the above-mentioned traditional herbal medicines have a drawback in that they do not have a therapeutic effect or require a long time for treatment or have a partial treatment effect, and thus have low effectiveness and require expensive manufacturing costs.

Known features of each of the compositions used in the present invention include the following.

Rhubarb (大黃, Rhei Rhizoma) is a perennial herb that belongs to the Madipulaceae family, which is native to western China. It may also be called (將軍). Its main ingredient is known as anthracene glucoside. Rhubarb is a well-known medicinal plant since ancient times, and it has been taken for constant constipation and dyspepsia as a laxative and dry stomach agent by drying the root of the root or root. In addition, rhubarb is cold in nature, has a sweet taste, and has a lot of power, and is used for diseases such as fecal discomfort, heat, bullshit, drool, red wine, and blood. It is also characterized by anti-inflammatory laxatives. Herbal medicine, high blood pressure treatment, antipyretic anti-inflammatory analgesic, skin disease treatment (Samhwangsasimtang, Injinho-tang, Soseunggi-tang, Jowiseunggi-tang, Daehwangmokdanpitang, etc.) has been combined. More applications are also used for the treatment of gastrointestinal bleeding, crude economy, stomach and laxatives. Meanwhile, emodine, a compound mainly contained in plants and plants such as rhubarb, is known to have an anticancer effect. However, there have not been reported examples of rhubarb used in the composition for treating burns.

Red stone is also known as dohwaseok (桃花 石), which is a clay containing iron oxide is composed of components such as aluminum silicate, calcium carbonate, magnesium sulfate. In addition, rediscovered paper has the effect of stopping convergence, hemostasis, and diarrhea, but it may interfere with the stomach, so care should be taken for those with a stomach disorder and those with a weak stomach.

Hansuseok (寒水石) is also known as jungsuseok (凝 水 石), it means that the salt water is hardened into a stone. It is used for the purpose of lowering heat, cutting off lumps in the stomach, and removing fraud. It is formulated in a prescription called Pungin-tang.

Yellow dandelion (黃丹) is effective in capturing and fever, and works to relieve pain. It also has the effect of stimulating birds and healing the phlegm.

Burns generally refer to damage to the body's skin caused by contact with heat, chemicals, electricity, or radiation. Medically, it is called thermal burn, and burns caused by steam of heated water or boiling water are also called steam burns.

Burns are classified into three types according to their area and depth of skin damage. First-degree burns become red, swollen and painful, and later discolor. Second-degree burns are blistered and sore, and later discolored. Third-degree burns cause necrosis and ulceration in tissues, and are often followed by scars, jails, and keloids. A wider range of burns leads to fever and difficulty breathing, loss of water and protein in the body, leading to dehydration, shock and kidney failure, and infection of the wound. In adults, burns of more than one-third of the body's total area are life-threatening. The first thing to do in the treatment of severe burns is blood transfusion, which corrects the imbalance of body fluids and salts, and then prevents infection, treats wounds, and transplants skin.

The present inventors have completed the present invention by finding that the composition consisting of rhubarb, red stone paper, hansuseok and yellow macula has an excellent effect on burn treatment.

It is an object of the present invention to provide a composition for treating burns.

In order to achieve the above object, the present invention provides a composition for the treatment of burns consisting of red stone, hansuseok, macula and rhubarb, and a method for preparing an external preparation by mixing them with a mutant.

Hereinafter, the present invention will be described in detail.

Specifically, the present invention provides a composition for treating burns consisting of 40-44% by weight of red paper, 20-23% by weight of sulphide, 20-23% by weight of dandan and 10-14% by weight of rhubarb.

In another aspect, the present invention provides a composition for the treatment of burns made by combining a pharmaceutically acceptable ointment in addition to the composition. In this case, as the oleaginous agent, those selected from petroleum jelly, paraffin, vegetable oil, lard, wax, and sweet rice ointment may be used. The process of the ointment is for convenience of use, it shows an excellent therapeutic effect only in the form of powder formulated in the composition.

In another aspect, the present invention is characterized in that the reddish paper, Hansuseok, yellow algae and rhubarb are dried and finely pulverized and blended according to the above composition, and then mixed with a pharmaceutically acceptable meat preparation in a ratio of 1: 9-9: 1. It provides a method for producing a composition for burn treatment.

In another aspect, the present invention provides a composition for the treatment of wound or suppuration consisting of 40-44% by weight of red paper, 20-23% by weight of sulphide, 20-23% by weight of yellow sand and 10-14% by weight of rhubarb.

The composition for burn treatment consisting of the composition is applied to the burn site 3-4 times a day. The effective amount may vary depending on the extent of the burn or the area of the affected part, and therefore cannot be specifically limited.

As a result of applying the external preparation prepared in the composition of the present invention to the burned area, after the application of the extreme heat sensation disappears and pain is alleviated, the patient is soon stabilized and tissue cells are revived in a short time, and the burn healing effect is very excellent. Could know.

In addition, the external preparation prepared from the composition of the present invention exhibits excellent therapeutic effects even on wounds or purulent wounds.

Hereinafter, the present invention will be described in more detail with reference to Examples.

However, the following examples are illustrative of the present invention, and the content of the present invention is not limited by the examples.

On the other hand, prior to the embodiment was prepared in the composition of the following preparation of the ointment for producing a composition of the present invention. This follows the prescription example described in the pharmacopeias.

<Manufacture example 1> Production of sweet rice ointment

Simple ointment (KP VI) was prepared by the following formulation.

Yellow beeswax 330

Vegetable Oil q.s.

Total quantity 1000

When the ideal is melted by warming in the water bath and completely dissolved, stop the heating and mix until it hardens.

Production Example 2 Preparation of White Ointment

White ointment (KP VI) was prepared by the following formulation.

White beeswax 50

Sorbitan sesquioleate 20

White petrolatum q.s.

Total quantity 1000

The wax is heated in a water bath to dissolve it, and it is dissolved by adding sesquioleate sorbitan and white petrolatum, and then the heating is stopped and stirred until it hardens.

<Production example 3> Production of salicylic acid phenol ointment

Salicylic acid-phenol ointment (KP VI) was prepared by the following formulation.

Phenol 30

Salicylic acid 50

Aromatics q.s.

White petrolatum or Ointment base q.s.

Total quantity 1000

Salicylic acid is moistened with a small amount of ether or ethanol, softened sufficiently to fine powder, and then softened to a small amount of white petrolatum. Separately, the phenol and fragrances previously dissolved in the water bath are softened together, followed by addition of the remaining amount of white petrolatum to soften the whole.

<Production example 4> Production of iktamol ointment

Ichhammol ointment (KP VI) was prepared by the following formulation.

Ichthammol 100

Purified lanolin 100

Vaselin 800

Total quantity 1000

Iktamol and purified lanolin are first softened on an ointment and then petroleum jelly is added to make a homogeneous product.

<Manufacture example 5> Production of galvanized ointment

Zinc oxide ointment (KP VI) was prepared by the following formulation.

Zinc Oxide 200

Purified lanolin 70

White ointment q.s.

Total quantity 1000

Zinc oxide is passed through a No. 200 (75 μm) sieve and then softened with purified lanolin first, followed by the addition of white ointment to soften it evenly. Instead of white ointment, white lead white petrolatum may be added.

<Example 1-6> Preparation of the composition for burn treatment

To prepare a composition for burn treatment in the formulation as shown in Table 1.

Composition of Burn Treatment Red earth Han Su-seok Yellow rhubarb Meat Example 1 43 22 22 13 not used Example 2 43 22 22 13 Formulation 1 to 100 Example 3 43 22 22 13 Formulation 2 to 100 Example 4 43 22 22 13 Formulation 3 100 Example 5 43 22 22 13 Formulation 4 100 Example 6 43 22 22 13 Formulation 5 100 Unit is g

The reddish paper, the hanseok, the yellow end and the rhubarb were dried and finely pulverized and blended according to the composition of Table 1 above. Some of them were left intact and the others were mixed in a ratio of 5: 5 to those obtained in pharmaceutically acceptable meat preparations, namely Formulations 1-5.

Experimental Example 1 Investigation of Toxicity and Side Effects

The preparations obtained in Examples 1-6 were applied to the skin of human arm 1.5 × 1.5 cm 2 area twice a day for 15 days to determine the toxicity and side effects.

After 15 days, no abnormalities in appearance were observed in the skin of the human arm to which the preparations obtained in Examples 1 to 6 were applied. Therefore, it was found that the preparations obtained in Examples 1 to 6 did not cause toxicity and side effects to human skin.

Experimental Example 2 Burn Treatment Effect

Clinical trials were conducted to investigate the effects of burn treatment using the agents obtained in Examples 1-6. 23 subjects of first degree burns, 14 subjects of second degree burns and three subjects of third degree burns were examined for the effect of burn treatment of the agent of the present invention. The clinical trial results are shown in Table 2 below. In the clinical trial results of the formulations of Examples 1-6, the effect of burn treatment was not related to the use of the medicinal agent or the type of the medicinal agent, and the results of Table 2 were based on the formulations of Examples 1-6. The average is shown.

Clinical Trial Results 5-6 days 7-8 days 17-20 days 21-23 days 50-55 days total members 1st degree burns 17 people 6 people - - - 23 people Second degree burns - - 9 people 5 people - 14 people A third degree burn - - - - 3 people 3 people

As can be seen from the clinical trial results, the agent made of the composition of the present invention shows an excellent effect on burn treatment.

The preparation made of the composition for treating burns of the present invention, when applied to the affected area, heat and pain disappears, and the burn healing effect and skin regeneration effect within a short period of time are excellent.

Claims (5)

Burn treatment composition consisting of 40-44% by weight of red paper, 20-23% by weight, 20-23% by weight of yellow algae and 10-14% by weight of rhubarb. The composition for treating burns according to claim 1, wherein a pharmaceutically acceptable ointment is added to the composition. The composition for treating burns according to claim 2, wherein the ointment is selected from petrolatum, paraffin, vegetable oil, lard, wax and sweet ointment as an oil-based base. Dry, finely crushed red stone paper, corn kernels, yellow algae and rhubarb and mix them according to the composition of claim 1, and then mix them with the pharmaceutically acceptable meat preparation in a ratio of 1: 9-9: 1. Method for the preparation of a therapeutic composition. A composition for treating wounds or purulent conditions consisting of 40-44% by weight of red paper, 20-23% by weight, 20-23% by weight, and 10-14% by weight of rhubarb.