KR19980069202A - Cosmetic composition containing hinokitiol - Google Patents

Abstract

The present invention relates to a cosmetic composition containing hinokitiol. In order to prevent deterioration of a cosmetic composition due to microbial contamination which may occur when a cosmetic is manufactured or used, a cosmetic composition containing hinokitiol Is contained in an amount of 0.001 to 5 wt% based on the total weight of the composition, it is possible to provide a cosmetic composition which is excellent in preservative effect and is safe for skin sensitive to conventional preservatives.

Description

Cosmetic composition containing hinokitiol

The present invention relates to a cosmetic composition containing hinokitiol. More particularly, the present invention relates to a cosmetic composition containing hinokitiol, and more particularly, to a cosmetic composition containing hinokitiol, which is used in place of conventional chemically synthesized preservatives in order to prevent deterioration of cosmetics due to microbial contamination, Which is excellent in antiseptic effect and is safe for skin sensitive to conventional preservatives.

In general, cosmetics are mainly composed of ingredients that can be used as energy sources, such as bacteria, fungi, and yeast. Therefore, cosmetics can easily be altered by microorganisms, and their use and storage methods are easily exposed to microorganisms. To prevent corruption caused by various preservatives are used. Examples of the preservative which has been used in conventional cosmetics include parabens, imidazolidinyl urea, DMDMH, and 2-bromo-2-nitropropane-1,3-diol, phenoxyethanol, Sodium benzoate, benzyl alcohol, benzalkonium chloride, glutaral, quaternium-15, dichlorophene, methylene-4-isothiazolin-3-one, sorbic acid seed, triclosan acid, diazolininyl urea, Chlorhexidine di gluconate, hexamidine diisethionate, hibitane gluconate, and the like.

However, preservatives which have been used conventionally have various problems. First, when the chemical synthetic preservative is contained in cosmetics, it shows some side effects such as allergy to the skin and induction of skin inflammation though there are some differences, Scientists' paper (Contact Dermatitis, 1994, 30, 276-279) and the K. this. Published in a number of studies including K. E. Andersen, J. Appl. Cosmetol. 11, 65-68 (April-June 1993). Therefore, active research on a non-preservative system that does not use preservatives or reduce the amount of preservatives in cosmetics as much as possible has been under way. However, studies on a no-preservative system until now have been carried out in a vacuum state However, this method has a problem in that it is difficult to make it universal because a large-scale manufacturing facility is required.

Second, existing chemical synthetic preservatives, when contained in cosmetics, inhibit the preservative effect by various conditions, such as B. Peyey and F. FB Engle reported that parabens such as methyl paraben, ethyl paraben, propyl paraben, and butyl paraben are used with lecithin or filtered to reduce the flotation power (environmental sampling devices for neutralization of disinfectants, Presented at 4th Intl Symp on Contamination Control, 1978), K. KH Wallhauser has also reported that the antifouling performance is reduced by nonionic surfactants, cationic surfactants or polyethylene glycols, nonionic ethers, nonionic ester components, etc. (Antimicrobial preservatives used by the cosmetic industry, In: Cosmetic and Drug Preservation: Principles and Practice, ed, JJ Kabara, New York: Marcel Dekker Inc 614, 1984). Also, D Coates et al. Have reported that the repulsive force is lowered in the presence of depolymerized pyrrolidone, triacetin gum, polysorbate 20 and polysorbate 80 (Preservative / colloid interaction, Mfg Chem Aerosol News, 44 (10) 34 (1773)), it is known that imidazolidinyl urea easily dissolves buoyancy under high temperature conditions, and that when subjected to dilution or filtration, the impermeability decreases. And P. Lorenz found that the repelling force was reduced under neutral or alkaline conditions in the case of 2-bromo-2-nitropan-1,3-diol (5-Bromo-5-nitro- 3-dioxane: A preservative for cosmetics, Cosm Toil, 91 89-91 (1977), DC Steinberg reports that 2-bromo-2-nitropan- (Cosmetic preservatives, Drug Cosm Ind, 32 (1984)).

Accordingly, the present inventors have repeatedly conducted studies to solve the above-mentioned problems. As a result, the inventors of the present invention have found that, as a substance having excellent preservative effect without exhibiting adverse effects on skin, hinokitiol, which is a component of wood of Chamacyparis taiwanensis wood The present invention has been completed based on the fact that this microorganism growth can be inhibited.

Accordingly, an object of the present invention is to provide a cosmetic composition which is excellent in preservative effect without skin irritation.

In order to achieve the above object, the cosmetic composition of the present invention is characterized by containing hinokitiol, which is a component of wood of Chamacyparis taiwanensis wood, in an amount of 0.001 to 5.0 wt% based on the total weight of the composition do.

The above and other objects, features, and advantages of the present invention will become apparent to those skilled in the art from the following detailed description.

Hereinafter, the present invention will be described in more detail.

The hinokitiol used in the present invention is a component of wood of Chama Pisces taiwanensis , which is white or pale yellow crystals and has not only excellent antimicrobial activity but also has a whitening effect and cell activating action, It is a natural substance which is also used as a preservative for external medicine, hair growth, hair follicle and salt, and as a raw material preservative.

In the present invention, the hinokitiol may be used in combination with a hinokitiol salt such as an alkali metal salt such as a sodium salt, a potassium salt, or an alkaline earth metal salt such as a magnesium salt. The content of the hinokitiol is 0.001-5.0 wt. %, Preferably 0.01 to 1.0 wt%. If the content of the hinokitiol is less than 0.001 wt%, the preservative effect can not be expected at all. If the content exceeds 5.0 wt%, the effect of other cosmetic ingredients is affected, It is preferable that it is contained in an amount.

The cosmetic composition of the present invention is not particularly limited in its formulation and examples thereof include softening lotion, convergent lotion, nutritional lotion, cream, essence, pack, cleansing foam, transparent gel product, foundation, mascara, Gel, shampoo, rinse, body cleanser, and the like. In the cosmetic composition of each formulation, components other than the above-mentioned hinokitiol may be mixed and selected without difficulty by those skilled in the art depending on the formulations of the other cosmetics, the purpose of use, and the like.

Best Mode for Carrying Out the Invention Hereinafter, the structure and effect of the present invention will be described in more detail with reference to Examples and Test Examples of the present invention. However, the present invention is not limited to these examples.

[Examples 1 to 5 and Comparative Examples 1 to 5]

ingredient Example Comparative Example One 2 3 4 5 One 2 3 4 5 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Liquid paraffin 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 glycerin 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 Wax 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Propylene glycol 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Cetostearyl alcohol 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.5 Chin type monostearate stearate 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Polyoxyethylene monostearate (20) sorbitan 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Stearic acid 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Sorbitan sesquioleate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Methylpolysiloxane 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Spices 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Triethanolamine 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Sodium ethylenediaminetetraacetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Methyl paraben 0.2 0.2 0.2 0.2 Propylparaben 0.05 0.05 0.1 Imidazolidinyl urea 0.4 0.4 Hinokitiol 0.01 0.05 0.1 0.5 1.0

[Examples 6 to 10 and Comparative Examples 6 to 10]

ingredient Example Comparative Example 6 7 8 9 10 6 7 8 9 10 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Liquid paraffin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 glycerin 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Propylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Polyoxyethylene monostearate (20) sorbitan 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Cetostearyl alcohol 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 0.8 Sorbitan sesquioleate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Methylpolysiloxane 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Chin type monostearate stearate 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Stearic acid 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Spices 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Carboxyvinyl polymer 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 Triethanolamine 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 0.12 Sodium ethylenediaminetetraacetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Benzophenone-5 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Methyl paraben 0.2 0.2 0.2 0.2 Propylparaben 0.05 0.05 0.1 Imidazolidinyl urea 0.4 0.4 Hinokitiol 0.01 0.05 0.1 0.5 1.0

[Examples 11 to 15 and Comparative Examples 11 to 14]

ingredient Example Comparative Example 11 12 13 14 15 11 12 13 14 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Betaine 8.0 8.0 8.0 8.0 8.0 8.0 8.0 8.0 8.0 Natto sword 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 glycerin 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 ethanol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Aminopropane sulfonic acid liquid seed 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Seaweed extract 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Gold Euphoria extract 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Diel panthenol 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Polyoxyethylene hardened castor oil 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Allantoin 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Carboxyvinyl polymer 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 0.13 Spices 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Potassium hydroxide 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Benzophenone-5 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Ethylenediamine sodium acetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Methyl paraben 0.1 0.1 0.15 Propylparaben 0.05 Hinokitiol 0.01 0.05 0.1 0.5 1.0

[Examples 16 to 19 and Comparative Examples 15 to 18] Skin lotions

ingredient Example Comparative Example 16 17 18 19 15 16 17 18 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 ethanol 7.0 7.0 7.0 7.0 7.0 7.0 7.0 7.0 glycerin 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Betaine 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Polyoxyethylene hardened castor oil 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Phenyl dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Spices 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Carboxyvinyl polymer 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Potassium hydroxide 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Sodium ethylenediaminetetraacetate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Benzophenone-5 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Methyl paraben 0.1 0.1 0.15 Propylparaben 0.05 Hinokitiol 0.01 0.02 0.05 0.1

[Test Example 1]

20 to 30 g of each of the cosmetics of Examples 1 to 19 and Comparative Examples 1 to 18 was precisely put in a container washed with alcohol, and then Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and the like were added to the samples so as to have a number of 10 ⁶ per gram of the sample, and then stored in a 35 ° C thermostat for 4 weeks. Were checked every 1, 7, 14, 21, and 28 days from the day of inoculation, and the results are shown in Table 1. In the case of fungi, a mixture of Penicillium luteum and Aspergillus flavus was added to the samples so that the number of samples was 10 ⁶ per gram of the sample, and the mixture was stored in a 25 ° C thermostatic chamber for 30 days , The presence or absence of swelling and the presence of hyphae and spore formation on the surface of the sample were observed at intervals of 7 days, and the results are shown in Table 1.

[Table 1]

Cosmetics Bacteria (× 10 ³ cells / g) mold After 1 day After 7 days After 14 days After 21 days After 28 days Example 1 2,500 217 112 78 35 + Example 2 1,200 110 68 40 30 + Example 3 800 70 63 30 5 - Example 4 800 46 30 12 0.4 - Example 5 700 32 15 5 0.1 - Comparative Example 1 8,100 10,000 10,000 10,000 10,000 +++ Comparative Example 2 4,200 450 410 200 725 ++ Comparative Example 3 3,800 137 52 67 83 ++ Comparative Example 4 1,200 73 40 10 3 - Comparative Example 5 1,000 45 30 8 2 - Example 6 1,600 120 65 35 12 + Example 7 1,000 80 35 10 10 - Example 8 700 53 18 0.8 0.6 - Example 9 500 37 10 0.5 0.4 - Example 10 300 10.8 0.4 0.4 0.4 - Comparative Example 6 7,500 10,000 10,000 10,000 10,000 +++ Comparative Example 7 8,800 8,000 10,000 10,000 10,000 ++ Comparative Example 8 7,000 6,000 3,000 1,000 3,000 + Comparative Example 9 5,200 74 57 42 12 - Comparative Example 10 4,500 40 23 10 0.3 - Cosmetics Bacteria (× 10 ³ cells / g) mold After 1 day After 7 days After 14 days After 21 days After 28 days Example 11 800 129 80 50 30 + Example 12 600 80 50 26 0.8 - Example 13 300 56 46 10 0.2 - Example 14 100 12 4 0.7 0.8 - Example 15 5,100 0.8 0.4 0.4 0.3 - Comparative Example 11 7,800 8,000 8,000 10,000 10,000 ++ Comparative Example 12 2,000 120 90 50 20 + Comparative Example 13 1,000 50 32 10 12 - Comparative Example 14 890 70 43 20 20 - Example 16 200 90 70 60 32 - Example 17 210 40 30 12 4 - Example 18 100 23 12 3 0.1 - Example 19 100 13 2 0.8 0.8 - Comparative Example 15 1,800 300 98 50 30 + Comparative Example 16 200 50 30 15 8 - Comparative Example 17 100 10 2.1 0.1 0.1 - Comparative Example 18 120 20 8 0.4 0.3 - * -: Good for 4 weeks +: Fungus on the wall or lid within 4 weeks ++: Fungal on part of the surface +++: Mold on the whole surface

As can be seen from Table 1, it can be seen that the cosmetic composition containing the hinokitiol according to the present invention exhibits similar or excellent preservative effect as compared with the cosmetic composition containing the conventional chemical synthetic preservative.

[Test Example 2] Skin stability

The skin patches of the examples and comparative examples were subjected to a skin patch test on the human body, and skin safety was evaluated according to the following evaluation criteria, and the results are shown in Table 2.

* Evaluation standard

+++: Skin irritation is so severe that it is difficult to use in cosmetics.

++: Skin irritation is serious.

+: There is little skin irritation, but it is easy to use for cosmetics.

±: Almost no stimulation.

-: No irritation is possible for sensitive skin.

[Table 2]

Name of sample Comparative Example 5 Example 3 Example 4 Example 5 Comparative Example 10 Example 7 Example 8 Example 9 Example 10 Judgment result ++ - - ± + - - - ± Name of sample Comparative Example 13 Example 12 Example 13 Example 14 Example 15 Comparative Example 18 Example 17 Example 18 Example 19 Judgment result + - - - ± + - - -

As can be seen from Table 2, the cosmetic of the present invention containing hinokitiol has much less skin irritation than the comparative examples containing the conventional chemical synthetic preservative.

As can be seen from the above description, the present invention contains hinokitiol as a natural ingredient in place of the chemical synthetic preservative which has been used to prevent the deterioration of cosmetics due to contamination of microorganisms and the like, To provide a cosmetic composition which can be safely used on sensitive skin.

Claims (2)

Wherein the cosmetic composition contains at least one selected from the group consisting of hinokitiol, alkali metal salts of hinokitiol, and alkaline earth metal salts of hinokitiol in an amount of 0.001 to 5 wt% based on the total weight of the composition. The cosmetic composition according to claim 1, wherein the cosmetic composition is formulated with a softening agent, a convergent lotion, a nutritional lotion, a cream, an essence, a pack, a cleansing foam, a transparent gel product, a foundation, a mascara, a hair cream, a hair styling gel, a shampoo, Wherein the cosmetic composition is a cosmetic composition.