KR102932302B1 - 자연살해세포의 분화를 위한 배지 및 방법 - Google Patents

자연살해세포의 분화를 위한 배지 및 방법

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Publication number
KR102932302B1
KR102932302B1 KR1020217022986A KR20217022986A KR102932302B1 KR 102932302 B1 KR102932302 B1 KR 102932302B1 KR 1020217022986 A KR1020217022986 A KR 1020217022986A KR 20217022986 A KR20217022986 A KR 20217022986A KR 102932302 B1 KR102932302 B1 KR 102932302B1
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cells
cell
medium
population
differentiation medium
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KR20210114422A (ko
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누신 타바타베이-자바레
알베르투스 베르네루스 워그눔
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스템셀 테크놀러지스 캐나다 인크.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

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  • Health & Medical Sciences (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020217022986A 2018-12-21 2019-12-20 자연살해세포의 분화를 위한 배지 및 방법 Active KR102932302B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862783341P 2018-12-21 2018-12-21
US62/783,341 2018-12-21
PCT/CA2019/051875 WO2020124256A1 (en) 2018-12-21 2019-12-20 Media and methods for differentiating natural killer cells

Publications (2)

Publication Number Publication Date
KR20210114422A KR20210114422A (ko) 2021-09-23
KR102932302B1 true KR102932302B1 (ko) 2026-02-27

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US (1) US20220056412A1 (enExample)
EP (1) EP3898951A4 (enExample)
JP (2) JP2022514393A (enExample)
KR (1) KR102932302B1 (enExample)
CN (1) CN113383070A (enExample)
CA (1) CA3124266A1 (enExample)
SG (1) SG11202106565WA (enExample)
WO (1) WO2020124256A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113337466B (zh) * 2021-07-13 2023-03-24 杭州原生生物科技有限公司 一种无血清nk分化培养基及其制备方法
CN113789299B (zh) * 2021-10-18 2023-03-24 新鲁细胞生物科技(海南)有限公司 一种脐血nk细胞的体外增殖培养基、体外培养试剂盒和体外培养方法
CN119137261A (zh) 2021-12-17 2024-12-13 优莫佳生物制药股份有限公司 细胞毒性先天淋巴样细胞及其用途
KR20250022800A (ko) 2022-06-10 2025-02-17 우모자 바이오파마 인코포레이티드 조작된 줄기 세포 및 그의 용도
US20260176585A1 (en) * 2022-11-07 2026-06-25 Maru Therapeutics Co., Ltd. Cultivation method for enhancing differentiation efficiency and functionality of nk cells
WO2024101863A1 (ko) * 2022-11-07 2024-05-16 마루테라퓨틱스 주식회사 줄기세포 기원 및 발현 마커에 따른 nk 세포 분화 효율 증진 방법
IL328711A (en) 2023-12-13 2026-07-01 Umoja Biopharma Inc Myeloid cells derived from engineered induced stem cells and methods for differentiating and using them
WO2026123001A2 (en) 2024-12-06 2026-06-11 Umoja Biopharma, Inc. Lineage-loci engineered cell therapy and related methods of producing and using same
WO2026123000A2 (en) 2024-12-06 2026-06-11 Umoja Biopharma, Inc. Cytokine armored engineered innate lymphoid cells and related methods

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US20150374754A1 (en) * 2007-11-09 2015-12-31 Cellprotect Nordic Pharmaceuticals Ab Expanded nk cells

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WO2013119118A1 (en) * 2012-02-08 2013-08-15 Ipd-Therapeutics B.V. Ex vivo nk cell differentiation from cd34+ hematopoietic cells
KR20230146101A (ko) * 2014-12-31 2023-10-18 안트로제네시스 코포레이션 천연 킬러 세포 및 그의 용도
WO2016191879A1 (en) * 2015-06-05 2016-12-08 Héma-Québec Methods for culturing and/or differentiating hematopoietic stem cells into progenitors and uses thereof
US12076342B2 (en) * 2016-04-08 2024-09-03 The Governing Council Of The University Of Toronto Method for generating progenitor t cells from stem and/or progenitor cells and use of same
US20190209618A1 (en) * 2016-04-26 2019-07-11 Mcmaster University Methods and compositions for expansion of hematopoietic stem and/or progenitor cells employing a cytochrome p450 1b1 (cyp1b1) inhibitor or a musashi-2 (msi2) activator
GB201706544D0 (en) * 2017-04-25 2017-06-07 Plasticell Ltd Method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150374754A1 (en) * 2007-11-09 2015-12-31 Cellprotect Nordic Pharmaceuticals Ab Expanded nk cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal of Immunology, Vol. 200, Issue Supplement 1, p103.4(2018.05.01.)*

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Publication number Publication date
EP3898951A4 (en) 2022-08-31
SG11202106565WA (en) 2021-07-29
WO2020124256A1 (en) 2020-06-25
CA3124266A1 (en) 2020-06-25
JP2025024025A (ja) 2025-02-19
KR20210114422A (ko) 2021-09-23
US20220056412A1 (en) 2022-02-24
JP2022514393A (ja) 2022-02-10
CN113383070A (zh) 2021-09-10
EP3898951A1 (en) 2021-10-27

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