KR102926602B1 - 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물 - Google Patents

티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물

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Publication number
KR102926602B1
KR102926602B1 KR1020227000934A KR20227000934A KR102926602B1 KR 102926602 B1 KR102926602 B1 KR 102926602B1 KR 1020227000934 A KR1020227000934 A KR 1020227000934A KR 20227000934 A KR20227000934 A KR 20227000934A KR 102926602 B1 KR102926602 B1 KR 102926602B1
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mixture
cycloalkyl
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KR20220042344A (ko
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샹양 천
위청 팡
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광저우 이노케어 파마 테크 씨오., 엘티디.
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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KR1020227000934A 2019-06-28 2020-06-24 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물 Active KR102926602B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910572091.9 2019-06-28
CN201910572091.9A CN112142743A (zh) 2019-06-28 2019-06-28 杂环类化合物、其制备方法及其在医药学上的应用
PCT/CN2020/098105 WO2020259584A1 (en) 2019-06-28 2020-06-24 Heterocyclic compounds for mediating tyrosine kinase 2 activity

Publications (2)

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KR20220042344A KR20220042344A (ko) 2022-04-05
KR102926602B1 true KR102926602B1 (ko) 2026-02-11

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KR1020227000934A Active KR102926602B1 (ko) 2019-06-28 2020-06-24 티로신 키나아제 2 활성을 조정하기 위한 헤테로사이클릭 화합물

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Country Link
US (1) US12448382B2 (https=)
EP (1) EP3990449A4 (https=)
JP (1) JP7560136B2 (https=)
KR (1) KR102926602B1 (https=)
CN (2) CN112142743A (https=)
AU (1) AU2020301437B2 (https=)
BR (1) BR112021026531A2 (https=)
CA (1) CA3144799A1 (https=)
MX (1) MX2021015969A (https=)
PH (1) PH12021553257A1 (https=)
TW (1) TWI851747B (https=)
WO (1) WO2020259584A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用
TWI782599B (zh) * 2020-07-02 2022-11-01 美商輝瑞股份有限公司 胺基嘧啶基衍生物
CN113234081A (zh) * 2021-05-27 2021-08-10 东南大学 一种吡咯并吡唑衍生物与dmpeda做脲的制备方法
JP2024539280A (ja) 2021-10-25 2024-10-28 カイメラ セラピューティクス， インコーポレイテッド Ｔｙｋ２分解剤およびそれらの使用
WO2025124465A1 (en) * 2023-12-15 2025-06-19 Beijing Innocare Pharma Tech Co., Ltd. Method for treating atopic dermatitis

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
CN108137559A (zh) 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112142743A (zh) * 2019-06-28 2020-12-29 广州诺诚健华医药科技有限公司 杂环类化合物、其制备方法及其在医药学上的应用

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014500254A (ja) 2010-11-09 2014-01-09 セルゾーム リミティッド Ｔｙｋ２阻害剤としてのピリジン化合物およびそのアザ類似体
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
WO2013146963A1 (ja) 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
CN105622638A (zh) 2014-10-29 2016-06-01 广州康盛贝特医药技术有限公司 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用
CN108137559A (zh) 2015-07-09 2018-06-08 默克专利有限公司 用作btk抑制剂的嘧啶衍生物及其用途
JP2018524356A (ja) * 2015-07-09 2018-08-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｂｔｋ阻害剤としてのピリミジン誘導体及びその使用
WO2019060365A1 (en) 2017-09-20 2019-03-28 Kura Oncology, Inc. SUBSTITUTED MÉNINE-MLL INHIBITORS AND METHODS OF USE

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EP3990449A4 (en) 2023-07-26
WO2020259584A1 (en) 2020-12-30
CN112142743A (zh) 2020-12-29
CN114096532A (zh) 2022-02-25
CA3144799A1 (en) 2020-12-30
TWI851747B (zh) 2024-08-11
TW202115034A (zh) 2021-04-16
JP2022540353A (ja) 2022-09-15
EP3990449A1 (en) 2022-05-04
US20220112200A1 (en) 2022-04-14
JP7560136B2 (ja) 2024-10-02
BR112021026531A2 (pt) 2022-02-15
PH12021553257A1 (en) 2022-08-08
US12448382B2 (en) 2025-10-21
CN114096532B (zh) 2023-12-01
KR20220042344A (ko) 2022-04-05
MX2021015969A (es) 2022-04-18
AU2020301437A1 (en) 2022-02-17
AU2020301437B2 (en) 2026-02-26

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