KR102829200B1 - Ror 감마 조정제로서의 트리시클릭 술폰 화합물 - Google Patents

Ror 감마 조정제로서의 트리시클릭 술폰 화합물 Download PDF

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KR102829200B1
KR102829200B1 KR1020207035905A KR20207035905A KR102829200B1 KR 102829200 B1 KR102829200 B1 KR 102829200B1 KR 1020207035905 A KR1020207035905 A KR 1020207035905A KR 20207035905 A KR20207035905 A KR 20207035905A KR 102829200 B1 KR102829200 B1 KR 102829200B1
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disease
disorder
compound
vol
compounds
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KR20210009357A (ko
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티. 지. 무랄리 다르
질리 샤오
마이클 지. 양
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브리스톨-마이어스 스큅 컴퍼니
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020207035905A 2018-05-17 2019-05-16 Ror 감마 조정제로서의 트리시클릭 술폰 화합물 Active KR102829200B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862672802P 2018-05-17 2018-05-17
US62/672,802 2018-05-17
PCT/US2019/032555 WO2019222438A1 (en) 2018-05-17 2019-05-16 Tricyclic sulfone compound as a ror gamma modulator

Publications (2)

Publication Number Publication Date
KR20210009357A KR20210009357A (ko) 2021-01-26
KR102829200B1 true KR102829200B1 (ko) 2025-07-02

Family

ID=66691023

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207035905A Active KR102829200B1 (ko) 2018-05-17 2019-05-16 Ror 감마 조정제로서의 트리시클릭 술폰 화합물

Country Status (6)

Country Link
US (1) US10633339B2 (cg-RX-API-DMAC10.html)
EP (1) EP3793978A1 (cg-RX-API-DMAC10.html)
JP (1) JP2021524850A (cg-RX-API-DMAC10.html)
KR (1) KR102829200B1 (cg-RX-API-DMAC10.html)
CN (1) CN112119060A (cg-RX-API-DMAC10.html)
WO (1) WO2019222438A1 (cg-RX-API-DMAC10.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12570609B2 (en) 2020-01-24 2026-03-10 Bristol-Myers Squibb Company Tricyclic sulfones as ROR gamma modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084595A2 (en) 2006-01-20 2007-07-26 Schering Corporation Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012052451A1 (en) * 2010-10-18 2012-04-26 Merz Pharma Gmbh & Co. Kgaa Metabotropic glutamate receptor modulators
CN107709295B (zh) 2015-05-07 2021-05-04 百时美施贵宝公司 作为RORγ调节剂的三环砜类
WO2018071620A1 (en) 2016-10-13 2018-04-19 Bristol-Myers Squibb Company Heterocyclic sulfones as ror gamma modulators

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084595A2 (en) 2006-01-20 2007-07-26 Schering Corporation Carbocyclic and heterocyclic arylsulfones as gamma secretase inhibitors

Also Published As

Publication number Publication date
CN112119060A (zh) 2020-12-22
EP3793978A1 (en) 2021-03-24
JP2021524850A (ja) 2021-09-16
US20190352261A1 (en) 2019-11-21
KR20210009357A (ko) 2021-01-26
WO2019222438A1 (en) 2019-11-21
US10633339B2 (en) 2020-04-28

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