KR102813281B1 - 병용 사용을 위한 bcma 및 cd3에 대한 항증식성 화합물 및 이중특이성 항체 - Google Patents

병용 사용을 위한 bcma 및 cd3에 대한 항증식성 화합물 및 이중특이성 항체 Download PDF

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KR102813281B1
KR102813281B1 KR1020207036733A KR20207036733A KR102813281B1 KR 102813281 B1 KR102813281 B1 KR 102813281B1 KR 1020207036733 A KR1020207036733 A KR 1020207036733A KR 20207036733 A KR20207036733 A KR 20207036733A KR 102813281 B1 KR102813281 B1 KR 102813281B1
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다니엘 더블유. 피어스
릴리 엘. 웡
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셀진 코포레이션
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020207036733A 2018-05-23 2019-05-22 병용 사용을 위한 bcma 및 cd3에 대한 항증식성 화합물 및 이중특이성 항체 Active KR102813281B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862675639P 2018-05-23 2018-05-23
US62/675,639 2018-05-23
PCT/US2019/033505 WO2019226761A1 (en) 2018-05-23 2019-05-22 Antiproliferative compounds and bispecific antibody against bcma and cd3 for combined use

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KR20210021996A KR20210021996A (ko) 2021-03-02
KR102813281B1 true KR102813281B1 (ko) 2025-05-28

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PT3796912T (pt) 2023-05-17
US20230181575A1 (en) 2023-06-15
MX2020012485A (es) 2021-04-28
HRP20230449T1 (hr) 2023-07-21
MX420366B (es) 2025-02-10
CY1126060T1 (el) 2023-11-15
FI3796912T3 (fi) 2023-05-11
LT3796912T (lt) 2023-06-12
DK3796912T5 (da) 2024-08-19
IL278853B1 (en) 2025-02-01
PL3796912T3 (pl) 2023-09-11
EP3796912A1 (en) 2021-03-31
JP7293256B2 (ja) 2023-06-19
WO2019226761A1 (en) 2019-11-28
EP3796912B1 (en) 2023-02-15
EP4218762A3 (en) 2023-08-16
RS64189B1 (sr) 2023-06-30
BR112020023704A2 (pt) 2021-02-17
US20190381035A1 (en) 2019-12-19
CA3101050A1 (en) 2019-11-28
AU2019274530B2 (en) 2024-09-19
CN113713095B (zh) 2025-07-15
IL278853A (en) 2021-01-31
SG11202011545YA (en) 2020-12-30
HUE061792T2 (hu) 2023-08-28
JP2021525248A (ja) 2021-09-24
ES2945214T3 (es) 2023-06-29
SMT202300142T1 (it) 2023-07-20
KR20210021996A (ko) 2021-03-02
JP7550922B2 (ja) 2024-09-13
SI3796912T1 (sl) 2023-07-31
AU2019274530A1 (en) 2020-12-10
US12053466B2 (en) 2024-08-06
EP4218762A2 (en) 2023-08-02
US11439637B2 (en) 2022-09-13
DK3796912T3 (da) 2023-05-15
IL278853B2 (en) 2025-06-01
EA202092830A1 (ru) 2021-04-08
US20240366593A1 (en) 2024-11-07
CN112399848B (zh) 2024-09-06
JP2023116613A (ja) 2023-08-22

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