KR102742741B1 - 스페이서를 포함하는 폴리펩타이드 조성물 - Google Patents

스페이서를 포함하는 폴리펩타이드 조성물 Download PDF

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KR102742741B1
KR102742741B1 KR1020207013590A KR20207013590A KR102742741B1 KR 102742741 B1 KR102742741 B1 KR 102742741B1 KR 1020207013590 A KR1020207013590 A KR 1020207013590A KR 20207013590 A KR20207013590 A KR 20207013590A KR 102742741 B1 KR102742741 B1 KR 102742741B1
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루툴 알. 샤
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프레시전 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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KR1020207013590A 2017-10-18 2018-10-17 스페이서를 포함하는 폴리펩타이드 조성물 Active KR102742741B1 (ko)

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KR1020247040963A KR20250010043A (ko) 2017-10-18 2018-10-17 스페이서를 포함하는 폴리펩타이드 조성물

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US201762574061P 2017-10-18 2017-10-18
US62/574,061 2017-10-18
PCT/US2018/056334 WO2019079486A1 (en) 2017-10-18 2018-10-17 POLYPEPTIDE COMPOSITIONS COMPRISING SPACERS

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KR102742741B1 true KR102742741B1 (ko) 2024-12-16

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KR1020247040963A Pending KR20250010043A (ko) 2017-10-18 2018-10-17 스페이서를 포함하는 폴리펩타이드 조성물

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US (2) US11771718B2 (https=)
EP (1) EP3697438A4 (https=)
JP (2) JP2021500882A (https=)
KR (2) KR102742741B1 (https=)
CN (1) CN111511391B (https=)
AU (2) AU2018352984B2 (https=)
CA (1) CA3079264A1 (https=)
IL (2) IL316522A (https=)
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EP3820484A4 (en) * 2018-07-10 2022-05-04 Precigen, Inc. ROR-1 SPECIFIC CHIMERA ANTIGEN RECEPTORS AND USES THEREOF
JP7627080B2 (ja) * 2018-08-31 2025-02-05 シアトル チルドレンズ ホスピタル ディー／ビー／エイ シアトル チルドレンズ リサーチ インスティテュート Ｂ７ｈ３キメラ抗原受容体を含む方法および組成物
SG11202104287RA (en) * 2018-11-06 2021-05-28 Univ Washington Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same
WO2020214937A1 (en) * 2019-04-19 2020-10-22 Allogene Therapeutics, Inc. Antibodies against 4g7-derived chimeric antigen receptors
EP3962527A4 (en) 2019-04-30 2023-11-01 Senti Biosciences, Inc. CHIMERIC RECEPTORS AND METHODS OF USE THEREOF
SE544015C2 (en) * 2019-06-18 2021-11-02 Tx Medic Ab Allogenic car-t cell therapy
CN114222763A (zh) * 2019-06-19 2022-03-22 尤利乌斯·马克西米利安维尔茨堡大学 在嵌合抗原受体设计中实现的超模块化IgG3间隔区结构域和多功能位点
CN114761084B (zh) * 2019-09-24 2023-10-27 加利福尼亚大学董事会 具有铰链结构域的Notch受体
CN112111014A (zh) * 2020-09-22 2020-12-22 廖文强 一种抗氧化嵌合型抗原受体和免疫细胞
MX2023008115A (es) * 2021-01-11 2023-09-11 Precigen Inc Terapia con receptores quiméricos.
US20240108653A1 (en) * 2021-02-05 2024-04-04 University Of Utah Research Foundation Compositions and methods for treating with car cells
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